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BMC Cancer 2022 Jun 25;22(1):701. Epub 2022 Jun 25.

Department of Paediatric Oncology and Haematology, Faculty of Medicine, Jagiellonian University, Medical College, Krakow, Poland.

Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the presentation and assessment of the incidence and clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centres of the Polish Paediatric Solid Tumours Study Group (PPSTSG). Read More

Int J Cancer 2022 Jun 25. Epub 2022 Jun 25.

Department of Urology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, People's Republic of China.

Conventional imaging examinations are not sensitive enough for the early detection of recurrent or metastatic lesions in renal cell carcinoma (RCC) patients. We aimed to explore the role of Ga- prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) in the detection of primary and metastatic lesions in such patients. We retrospectively analyzed 50 RCC patients who underwent Ga-PSMA-11 PET/CT from November 2017 to December 2020. Read More

J Pak Med Assoc 2022 Jun;72(6):1241-1242

Department of Hematology, Kuwait Cancer Control Center, Kuwait.

18F-Fluorodeoxyglucose (FDG) PET-CT is an excellent imaging modality for the evaluation of non-Hodgkin lymphoma (NHL). We report a case of a 45-year-old woman presented with a large right breast mass and suspicious right axillary lymph nodes referred for 18F-FDG PET-CT for staging. 18F-FDG PET-CT images show large hypermetabolic right breast mass infiltrating the skin, multiple hypermetabolic right axillary and subpectoral lymph nodes, along with multiple hypermetabolic bone lesions at axial and appendicular skeleton. Read More

Urol Oncol 2022 Jun 21. Epub 2022 Jun 21.

Department of Medicine, University of California, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA.

Background: Skeletal-related events (SREs) from bone metastases disease carry significant morbidity in men with metastatic castration resistant prostate cancer (mCRPC). The differential risk of SREs among patients receiving abiraterone acetate (AA) or enzalutamide (ENZ) is unknown.

Methods: To compare the risk of SREs among men with mCRPC receiving AA or ENZ, a retrospective cohort study using the SEER-Medicare Linked Database was conducted. Read More

Prostate 2022 Jun 23. Epub 2022 Jun 23.

Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: To investigate the prognostic value and potential therapeutic target of the baseline serum hormones in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone.

Methods: This retrospective study was performed in patients with mCRPC receiving abiraterone acetate (AA) from July 2016 to September 2020. Patients who had serum hormone tests within 2 weeks before AA treatment were included. Read More

Cureus 2022 May 21;14(5):e25192. Epub 2022 May 21.

Otolaryngology, Gifu University Graduate School of Medicine, Gifu, JPN.

Signet-ring cell/histiocytoid carcinoma (SRCHC) is a rare, aggressive neoplasm that often originates in the eyelid. We present a rare case of a 64-year-old male with SRCHC and papillary thyroid carcinoma (PTC) that underwent exome panel sequencing with next-generation sequencing (NGS). In addition, we reviewed reports of genetic mutations in SRCHC and compared them with our results. Read More

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

San Salvatore Hospital, 67100 L'Aquila, Italy.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc. Read More

Diagnostics (Basel) 2022 Jun 12;12(6). Epub 2022 Jun 12.

Department of Oncology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.

We present the F-Fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) findings in a 57-year-old woman with post-menopausal bleeding diagnosed with hepatoid adenocarcinoma (HAC) with a primary tumour in the uterine corpus and a highly elevated level of serum-α-fetoprotein (S-AFP) at presentation. HAC is a variant of adenocarcinoma with hepatic differentiation representing a heterogeneous group of neoplasms that morphologically and immunphenotypically resemble hepatocellular carcinoma (HCC) but are of extrahepatic origin. Microscopically, they are usually poorly differentiated adenocarcinomas proliferating in solid sheets or in a trabecular or cord-like arrangement. Read More

In Vivo 2022 Jul-Aug;36(4):1647-1650

AntiCancer Inc, San Diego, CA, U.S.A.;

Background/aim: Although the 5-year survival rate for localized prostate cancer is nearly 100%, prognosis for patients with metastases, of which the bone is the most common site, is poor. In order to evaluate efficacy of treatments against metastatic prostate cancer, experimental tibia-bone-metastasis mouse models of prostate cancer have been previously established. In the present study, we used a novel procedure for establishment of an experimental tibiabone metastasis mouse model, with human PC-3 prostate cancer expressing green fluorescent protein (GFP), that more closely matches prostate cancer growing in the bone. Read More

Curr Oncol 2022 Jun 7;29(6):4155-4177. Epub 2022 Jun 7.

Diagnostic and Interventional Radiology Unit, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy.

Metastases are the main type of malignancy involving bone, which is the third most frequent site of metastatic carcinoma, after lung and liver. Skeletal-related events such as intractable pain, spinal cord compression, and pathologic fractures pose a serious burden on patients' quality of life. For this reason, mini-invasive treatments for the management of bone metastases were developed with the goal of pain relief and functional status improvement. Read More

Comput Intell Neurosci 2022 8;2022:6126061. Epub 2022 Jun 8.

Department of Medical Iconography, Baoji Central Hospital, Baoji 721008, Shaanxi, China.

This research aimed to explore the effect of using magnetic resonance imaging (MRI) radiomic features to establish a model for predicting distant metastasis under dynamic contrast-enhanced MRI imaging with deep learning algorithms. The deep learning algorithm was used to segment the images. A total of 96 cases with 100 lesions were included in the metastatic group, including 2 cases of bifocal breast cancer and 2 cases of multifocal breast cancer. Read More

Cancer Imaging 2022 Jun 17;22(1):29. Epub 2022 Jun 17.

Department of Nuclear Medicine, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

Aim: The aim of this study was to evaluate the clinical utility of SPECT/CT (imaging of uptake in tumor lesions and additional findings) and the additional value of planar imaging in order to simplify clinical imaging protocols and decrease patients burden.

Materials And Methods: One hundred consecutive patients with metastatic neuroendocrine tumor (NET) treated with PRRT were included. Post-therapy imaging was performed 24 h after each PRRT cycle by both whole-body planar imaging and abdominal- and thoracic SPECT/CT. Read More

Clin Nucl Med 2022 Jun 18. Epub 2022 Jun 18.

From the Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen.

Abstract: Polymorphous adenocarcinoma (PAC) is generally an indolent tumor that mostly commonly affects the minor salivary gland. Polymorphous adenocarcinoma with distant metastases is extremely rare. In this case, we reported 18F-FDG and 68Ga-FAPI PET/CT imaging findings in a rare case of epiglottic PAC with multiple bone metastases. Read More

Medicine (Baltimore) 2022 Jun 17;101(24):e29395. Epub 2022 Jun 17.

Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Prompt diagnosis of nontuberculous Mycobacterial (NTM) vertebral osteomyelitis is challenging, yet necessary to prevent serious morbidity and mortality. Here, we report 3 cases of vertebral osteomyelitis caused by NTM with imaging findings.

Patient Concerns: Case 1, a 58-year-old male patient, was admitted to our hospital because of the presence of a pulmonary mass for 6 months with cough and chest pain. Read More

Front Oncol 2022 30;12:894767. Epub 2022 May 30.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Breast cancer is a heterogeneous disease, and the human epidermal growth factor receptor 2 (HER2) expression may vary considerably between primary and metastatic lesions, or even within a single lesion. Repeated biopsies cannot always be performed. In this feasibility trial, we assessed whether a novel Ga-NOTA-MAL-MZHER2 (Ga-HER2) affibody PET/CT could determine the HER2 status of each lesion if there was a clinical need for it. Read More

BMJ Open 2022 Jun 15;12(6):e058898. Epub 2022 Jun 15.

Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.

Objective: To determine whether preoperative staging of high-risk prostate cancer with F-sodium-fluoride (F-NaF) positron emission tomography (PET) reduces the risk of skeletal metastases.

Design: Nationwide, population-based cohort study using real-world data.

Setting: The study used national health registries, including all sites in Denmark from 2011 to 2018. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 15. Epub 2022 Jun 15.

Fundación Santa Fe de Bogotá, Bogotá, Colombia.

Strahlenther Onkol 2022 Jun 15. Epub 2022 Jun 15.

Department of Radiation Oncology, Universitätsklinikum Ulm, Ulm, Germany.

Purpose: The DEGRO Expert Commission on Prostate Cancer has revised the indication for radiation therapy of the primary prostate tumor in patients with synchronous distant metastases with low metastatic burden.

Methods: The current literature in the PubMed database was reviewed regarding randomized evidence on radiotherapy of the primary prostate tumor with synchronous low metastatic burden.

Results: In total, two randomized trials were identified. Read More

JBJS Case Connect 2022 04 8;12(2). Epub 2022 Jun 8.

Cooper Bone and Joint Institute, Camden, New Jersey.

Case: A 73-year-old man with a medical history significant for renal cell carcinoma (RCC) presented with widespread osseous metastases and imaging suspicious for RCC metastasizing to a lipoma interdigitated within the right vastus lateralis. The patient's pathological fractures were surgically addressed, and the lipoma excised. Final histology revealed a thigh lipoma involved by metastatic RCC without direct extension. Read More

Int J Radiat Oncol Biol Phys 2022 Jun 9. Epub 2022 Jun 9.

Departments of Radiation Oncology, Division of Radiation Oncology; Departments of Investigational Cancer Therapeutics; Departments of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Purpose: The benefit of local consolidative therapy (LCT) for oligometastasis across histologies remains uncertain. EXTernal beam radiation to Eliminate Nominal metastatic Disease (EXTEND; NCTXXXX) is a randomized phase II basket trial evaluating the effectiveness of LCT for oligometastatic solid tumors. We report here the prospective results of the single arm "lead-in" phase intended to identify histologies most likely to accrue to histology-specific endpoints in the randomized phase. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 11. Epub 2022 Jun 11.

Department of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139, Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China.

Dalton Trans 2022 Jun 21;51(24):9541-9555. Epub 2022 Jun 21.

Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 40 Prague 2, Czech Republic.

Ligands combining a bis(phosphonate) group with a macrocycle function as metal isotope carriers for radionuclide-based imaging and for treating bone metastases associated with several cancers. However, bis(phosphonate) pendant arms often slow down complex formation and decrease radiochemical yields. Nevertheless, their negative effect on complexation rates may be mitigated by using a suitable spacer between bis(phosphonate) and the macrocycle. Read More

Arch Gynecol Obstet 2022 Jun 3. Epub 2022 Jun 3.

Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'an men Street, Xicheng District, Beijing, 100034, China.

A 45-year-old female (G1, P1) with HPV-52 infection and low-grade cervical cytology presented to our clinic with an asymptomatic cervical mass. She suffered amenorrhea for the past 3 years due to medication for thyroid cancer. Magnetic resonance imaging revealed a mass sized 7. Read More

World J Clin Cases 2022 May;10(14):4661-4668

Department of Hepatobiliary Surgery, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310003, Zhejiang Province, China.

Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Papillary thyroid microcarcinoma (PTMC) accounts for the majority of PTC cases. However, concurrent pulmonary and hepatic metastases of PTMC are rarely seen. Read More

BMC Cancer 2022 Jun 4;22(1):614. Epub 2022 Jun 4.

Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Longcheng Street NO.99, Taiyuan, 030032, China.

Objective: To investigate the feasibility, safety, and clinical application value of single photon emission computed tomography/computed tomography (SPECT/CT)-guided bone marrow biopsy (BMB) in breast cancer (BC) patients with suspected bone metastases (BM) and compare its diagnostic performance for detection of BM with SPECT/CT.

Methods: The records of breast cancer patients referred for bone scintigraphy (BS), SPECT/CT and SPECT/CT-guided BMB from January of 2018 to June of 2021 in our hospital were retrospectively reviewed. 49 Patients were consecutively included in this study, all 49 specimens were analyzed by pathological and immunohistochemical studies. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 3. Epub 2022 Jun 3.

Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Purpose: The aim of this study was to compare  Ga-NOTA-3P-TATE-RGD, a dual somatostatin receptor 2- and integrin αβ-targeting tracer, to  Ga-DOTATATE in a single group of patients with gastroenteropancreatic (GEP)-neuroendocrine tumours (NETs).

Methods: Thirty-five patients with histologically confirmed GEP-NETs (5 grade 1, 28 grade 2, and 2 grade 3 tumours) were prospectively enrolled with informed consent. The primary tumour mainly originated from the pancreas and rectum. Read More

Prostate 2022 Jun 2. Epub 2022 Jun 2.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background: The numbers needed to image to identify pelvic lymph node and/or distant metastases in newly diagnosed prostate cancer (PCa) patients according to risk level are unknown.

Methods: Relying on Surveillance, Epidemiology, and End Results (2010-2016), we tabulated rates and proportions of patients with (a) lymph node or (b) distant metastases according to National Comprehensive Cancer Network (NCCN) risk level and calculated the number needed to image (NNI) for both endpoints. Multivariable logistic regression analyses were performed. Read More

Anticancer Res 2022 Jun;42(6):3099-3108

Department of Urology, Kagoshima University, Kagoshima, Japan.

Background/aim: This study aimed to evaluate the therapeutic benefit of novel androgen receptor-targeted agents (ARTAs) in castration-resistant prostate cancer (CRPC) with bone metastases in Japan.

Patients And Methods: In followup to our prospective observational study (PROSTAT-BSI) from 2012 to 2018 on metastatic hormone-sensitive prostate cancer (mHSPC) and metastatic CRPC (mCRPC) before docetaxel initiation, we conducted this sub-analysis to investigate the benefit of ARTAs after clinical recurrence on overall survival (OS) in the real-world clinical setting in Japan. In this study, we compared patients who were treated with ARTA with those who received only vintage hormone therapy including docetaxel after clinical recurrence. Read More

Ann Med Surg (Lond) 2022 May 11;77:103617. Epub 2022 Apr 11.

Department of Orthopedic, Aleppo University Hospital, Aleppo, Syria.

Background: Ewing's sarcoma (ES) can affect any bone, but its occurrence in the scapula is extremely rare. Only 15 studies investigating this condition exist in the medical literature.

Materials And Methods: A literature search was conducted in PubMed and Scopus, and studies on ES of scapula published in the English medical literature were retrieved. Read More

Cancers (Basel) 2022 May 18;14(10). Epub 2022 May 18.

Institute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany.

The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis formation, the bone marrow microenvironment, and particularly adipocytes, play a pivotal role as growth mediators of disseminated tumor cells in the bone marrow. The aim of the present study is to non-invasively characterize the pathophysiologic processes in experimental bone metastasis resulting from accelerated tumor progression within adipocyte-rich bone marrow using multimodal imaging from magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT). Read More