Search Our Scientific Publications & Authors

J Magn Reson Imaging 2019 Apr 23. Epub 2019 Apr 23.

Mater Misericordiae University Hospital, Dublin, Republic of Ireland.

Technical advances in the last two decades have allowed rapid, high-resolution whole-body magnetic resonance imaging (WBMRI). MRI allows unparalleled visualization and detail in the imaging of bone marrow and surrounding soft tissues. The properties of nuclear magnetic resonance allow superb characterization of bone marrow constituents. Read More

Skeletal Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To determine the level of discrepancy between magnetic resonance imaging (MRI) and F-FDG PET-CT in detecting osseous metastases in patients with Ewing sarcoma.

Methods: Twenty patients with histopathologically confirmed Ewing sarcoma between 2000 and 2017 who underwent F-FDG PET-CT and MRI within a 4-week range were included. Each imaging modality was evaluated by a separate observer. Read More

Adv Radiat Oncol 2019 Apr-Jun;4(2):314-322. Epub 2019 Feb 19.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: This study aimed to compare outcomes of patients with prostate cancer with bone metastases treated with stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy (CFRT).

Methods And Materials: An institutional, retrospective review was conducted of patients with prostate cancer receiving radiation therapy to bone metastases. In-field failure (IFF) was the primary outcome of the study, and distant failure (DF) and biochemical failure (BF) were secondary outcomes. Read More

Medicine (Baltimore) 2019 Apr;98(16):e15245

Department of Comprehensive Internal Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning.

Rationale: Urothelial carcinoma, also named transitional cell carcinoma, is the most frequent occurring malignancy in the urinary system. It mainly invades the surrounding tissues and metastasizes to distant organs in later stages.

Patient Concerns: Here, we presented an unusual case of occult urothelial carcinoma primarily manifested as a multiorgan metastatic cancer in a 59-year-old man. Read More

Mol Clin Oncol 2019 May 5;10(5):506-510. Epub 2019 Mar 5.

Department of Uro-Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama 350-1298, Japan.

A 66-year-old Japanese male patient was referred to Saitama Medical University International Medical Center for treatment of bladder cancer (clinical stage T2 or higher without metastasis), and underwent radical cystectomy with pelvic lymphadenectomy. The histopathological diagnosis was high-grade urothelial carcinoma (pathological stage T2bN2, ly1, v0) and 2 cycles of adjuvant systemic chemotherapy (gemcitabine plus cisplatin) were administered. At 15 months after the operation, mediastinal and lung hilar lymph nodes and multiple bone metastases were identified on computed tomography imaging. Read More

Urology 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA; Center for Research on Health Care, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Objective: To quantify the use of downstream studies following staging bone scans in patients with muscle-invasive bladder cancer. Bone scans may be obtained in high-risk bladder cancer patients prior to radical cystectomy to exclude bone metastases. However, false positive bone scans can occur, resulting in the need for additional studies. Read More

Korean J Radiol 2019 May;20(5):812-822

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objective: To assess the diagnostic value of combining diffusion-weighted imaging (DWI) with conventional magnetic resonance imaging (MRI) for differentiating between pathologic and traumatic fractures at extremities from metastasis.

Materials And Methods: Institutional Review Board approved this retrospective study and informed consent was waived. This study included 49 patients each with pathologic and traumatic fractures at extremities. Read More

Rev Bras Ginecol Obstet 2019 Apr 16. Epub 2019 Apr 16.

Department of Specialized Medicine, Universidade Federal do Piauí, Teresina, PI, Brazil.

Background:  Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign. When the diagnosis is performed in stage IV, the most common sites of metastasis are the lungs, liver and bones. Central nervous system (CNS) metastasis is a rare condition. Read More

Front Oncol 2019 28;9:183. Epub 2019 Mar 28.

Department of Radiology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.

Insufficiency fracture (IF) can show increased uptake on a bone scan (BS). IFs are often misinterpreted as bone metastases if the characteristic "Honda sign" (H-sign) is invisible. The purpose of the present study was to evaluate the utility of magnetic resonance imaging (MRI) alone for the characterization of IF and bone metastasis after radiotherapy in patients with cervical cancer detected by BS. Read More

Sarcoma 2019 10;2019:1960593. Epub 2019 Mar 10.

Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

Introduction: Primary cardiac sarcoma (PCS) has a poor prognosis compared to other sarcomas due to late presentation, challenging resection, incidence of metastases, and limited efficacy of systemic therapies.

Methods: A medical record search engine was queried to identify patients diagnosed with PCS from 1992 to 2017 at the University of Michigan.

Results: Thirty-nine patients with PCS had a median age of 41 years (range 2-77). Read More

J Bone Oncol 2019 Jun 19;16:100232. Epub 2019 Mar 19.

University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.

Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance in bone formation and resorption. Activated fibroblast growth factor receptors (FGFRs) are important in regulation of tumor growth and bone remodeling. Read More

Jpn Dent Sci Rev 2019 Nov 20;55(1):76-79. Epub 2019 Mar 20.

Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.

Medication-related osteonecrosis of the jaw (MRONJ) is a significant side effect of antiresorptive and antiangiogenic drugs. Since MRONJ is intractable, early detection is the best way to limit progression. Bone scintigraphy and F- fluorodeoxyglucose positron-emission tomography can detect minimal and subclinical changes in bones earlier than conventional radiological modalities. Read More

J Neurosurg 2019 04 5:1-9. Epub 2019 Apr 5.

Departments of1Neurological Surgery.

Objective: Extracranial meningioma metastases are uncommon, occurring in less than 1% of patients diagnosed with meningioma. Due to the rarity of meningioma metastases, patients are not routinely screened for distant disease. In this series, we report their experience with meningioma metastases and results of screening for metastases in select patients with recurrent meningiomas. Read More

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Oncology, Royal Free London NHS Foundation Trust, London, UK.

We report a rare presentation of metastatic renal cell carcinoma (RCC) in a 71-year-old man who presented with persistent shoulder pain. MRI revealed widespread lytic lesions within the bones suggestive of metastatic disease but extensive imaging including CT chest, abdomen and pelvis with contrast and fluorodeoxyglucose-positron emission tomography did not identify a primary cancer. The diagnosis was ultimately made from a targeted bone and subsequently targeted liver biopsy, whereby immunohistochemistry was consistent with metastatic RCC (mRCC). Read More

Mol Imaging Radionucl Ther 2019 Mar;28(1):8-14

Aydın Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey

Objectives: To investigate the role of F-FDG positron emission tomography/computed tomography (PET/CT) in detection of recurrence in ovarian cancer patients with increased CA-125 levels.

Methods: Fifty-two patients (30-80 years old, mean: 58.5±10. Read More

Ear Nose Throat J 2019 Mar 15;98(3):158-164. Epub 2019 Feb 15.

1 Department of Otolaryngology-Head & Neck Surgery, Augusta University, Augusta, GA, USA.

The objective of our study is to assess the impact of equivocal or positive positron emission tomography combined with low-dose noncontrast computed tomography (PET/CT) findings in the chest on treatment for head and neck cancer (HNC). We reviewed charts of patients presented at Augusta University's Head and Neck Tumor Board (AUTB) between 2013 and 2016 with the following exclusion criteria: <18 years, Veterans Affairs patients, those with incomplete data, and those without a history of head and neck squamous cell carcinoma. The lung/thorax sections of the radiologists' PET/CT reports were graded as "Positive, Equivocal, or Negative" for chest metastases. Read More

Arch Ital Urol Androl 2019 Mar 29;91(1):60-62. Epub 2019 Mar 29.

Department of Urology, Policlinico San Martino Hospital, University of Genoa.

Introduction: Breast cancer (BrC) is the most common non-dermatologic cancer in women. It frequently metastasizes to lung, liver and bone, while the urinary bladder is considered as an unusual site for BrC metastases.

Materials And Methods: Four years after her first oncologic surgical approach, a known BrC patient complained of a left flank pain, dysuria and urgency. Read More

Eur Urol Oncol 2019 Feb 24;2(1):47-76. Epub 2018 Oct 24.

Nuclear Medicine Unit, University of Bologna, S. Orsola Hospital Bologna, Bologna, Italy.

Context: In patients treated for prostate cancer, a rising serum prostate-specific antigen (PSA) level is a first sign of relapse, but imaging is needed to determine the localization of the recurrence, which may be local, in lymph nodes, and/or metastatic. With the increasing success rate of earlier salvage therapy, the diagnosis has become pertinent when the recurrent PSA level is still very low.

Objective: To systematically review the literature on the role of the existing imaging techniques in patients with early recurrent prostate cancer. Read More

World J Mens Health 2019 Mar 5. Epub 2019 Mar 5.

Department of Urology, University Hospital Frankfurt, Frankfurt am Main, Germany.

Up to 50% of patients initially treated for prostate cancer in a curative intent experience biochemical recurrence, possibly requiring adjuvant treatment. However, salvage treatment decisions, such as lymph node dissection or radiation therapy, are typically based on prostate specific antigen (PSA) recurrence. Importantly, common imaging modalities (, computed tomography [CT], magnetic resonance imaging, and bone scan) are limited and the detection of recurrent disease is particularly challenging if PSA is low. Read More

Magn Reson Imaging 2019 Mar 24;60:76-84. Epub 2019 Mar 24.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.

Purpose: To identify texture features of multiparametric MRI (mp-MRI) for pre-treatment prediction of bone metastases (BM) in patients with prostate cancer (PCa).

Patients And Methods: One-hundred and seventy-six patients with clinicopathologically confirmed PCa were enrolled，and the data was gathered from January 2008 to January 2018. A total of 976 texture features were extracted from T2-weighted (T2-w) and dynamic contrast-enhanced T1-weighted (DCE T1-w) MRI. Read More

AJR Am J Roentgenol 2019 Mar 27:1-8. Epub 2019 Mar 27.

1 Department of Radiology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287.

Objective: The purpose of this study was to review the efficacy and durability of pain control and local tumor control using microwave ablation and cementoplasty in treating extraspinal osseous tumors. Painful osseous metastases are a common cause of cancer-related morbidity. Percutaneous thermal ablation presents an attractive minimally invasive option in this vulnerable patient group. Read More

Eur Radiol 2019 Mar 26. Epub 2019 Mar 26.

The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

Objective: To compare whole-body MRI (WB-MRI) at 1.5/3T and bone scintigraphy in the skeletal staging of Ewing sarcoma (ES) of bone.

Methods: All patients with a histological diagnosis of ES of bone between 2007 and 2018 were retrospectively reviewed. Read More

Nucl Med Commun 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiation Sciences and Technologies and Health Biosignals, Lisbon School of Health Technology, Lisbon, Portugal.

Objectives: This work aims to assess whether the biochemical response of radium-223-dichloride treatment can be predicted based on the pretherapy bone scan, and consequently if bone scan index (BSI) and maximum lesion intensity have a place as alternatives or as complements to extent of bone disease (EOBD) scoring in predicting biochemical response to treatment. Many cases of advanced prostate cancer have evidence of bone metastasis. Accurate EOBD quantification could help predict the response to radium-223-dichloride therapy. Read More

J Orthop 2019 May-Jun;16(3):206-210. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Loma Linda University Medical Center, 11406 Loma Linda Drive, Suite 218, Loma Linda, CA, 92354, USA.

Purpose: Myxoid liposarcoma has a propensity to metastasize to bone. MRI is the preferred modality for detecting bone disease. We evaluated multiple MRI sequences to determine an optimal screening method. Read More

Hormones (Athens) 2019 Mar 23. Epub 2019 Mar 23.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo 636, 95122, Catania, Italy.

Introduction: Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in some cases, it may be complicated by brown tumors, mimicking bone metastases. Synchronous parathyroid and papillary thyroid carcinomas are rare. Read More

Clin Imaging 2019 Mar 11;55:165-173. Epub 2019 Mar 11.

Department of Radiology, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.

Objective: To determine the usefulness of adding contrast-enhanced (CE) magnetic resonance imaging (MRI) to conventional MRI for evaluation of spinal metastases.

Materials And Methods: One-hundred-and-two whole spine MR examinations, obtained for metastasis work-up within a 2-month period, from 65 men and 37 women (mean age, 64 years) with extra-spinal tumor, who also underwent CE-MRI, were retrospectively evaluated by three radiologists. The number of spine segments with bone marrow involvement was interpreted using a 3-point confidence scale (probable metastasis, equivocal, probably benign) during session 1 (conventional imaging) and session 2 (addition of CE-MRI to conventional imaging). Read More

Vet Radiol Ultrasound 2019 Mar 20. Epub 2019 Mar 20.

Queen's Veterinary School Hospital, Madingley Rd, Cambridge, UK.

An 8-year-old male intact miniature poodle presented for blindness, obtundation, tetraparesis, and vestibular signs. Magnetic resonance imaging, radiography, and ultrasound revealed a left piriform lobe lesion, right cerebellar and left brainstem lesions, and hydrocephalus and bilateral calvarial defects. Histopathology confirmed a choroid plexus carcinoma with meningeal and intraventricular metastases. Read More

Eur Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Objectives: To compare observer performance of detecting bone metastases between bone scintigraphy, including planar scan and single-photon emission computed tomography, and computed tomography (CT) temporal subtraction (TS).

Methods: Data on 60 patients with cancer who had undergone CT (previous and current) and bone scintigraphy were collected. Previous CT images were registered to the current ones by large deformation diffeomorphic metric mapping; the registered previous images were subtracted from the current ones to produce TS. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14819

Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, PR China.

Rationale: Spinal metastases are always associated with specific pain of back and limbs caused by nerve root compression. Although percutaneous endoscopic lumbar discectomy (PELD) has been widely performed on patients with back and radicular pain originating from lumbar disc herniation, this minimally invasive surgery is rarely used for the treatment of spinal metastases.

Patient Concerns: A 71-year-old woman with colon cancer and a known L3 vertebral body metastasis presented with significant progressive pain of low back and limbs. Read More

Ann Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: This meta-analysis aims to establish the diagnostic performance of F-NaF-PET/CT for the detection of bone metastases in prostate cancer patients. The performance of F-NaF-PET/CT was compared with other imaging techniques in the same cohort of patients.

Methods: A systematic search was performed in PubMed/Medline and EMBASE (last Updated, September 28, 2018). Read More

Vet Radiol Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Diagnostic Imaging, Willows Veterinary Centre and Referral Centre, Solihull, UK.

A 9-year-old, male neutered old English Sheepdog was presented for further investigation of altered mentation, impaired vision, and hemineglect syndrome of 10 days duration. An MRI study of the brain revealed multifocal, contrast-enhancing intra-axial lesions that had a stippled hypointense appearance in all sequences but lacked evidence of a strong signal void on T2* images. Histological examination of the brain postmortem confirmed the lesions were metastases arising from an osteosarcoma, which was later identified in the right humerus. Read More

Asia Pac J Clin Oncol 2019 Mar 12;15 Suppl 2:14-19. Epub 2019 Mar 12.

Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.

Aim: To evaluate the outcome and toxicities of stereotactic ablative radiotherapy (SABR) for skeletal metastasis in a tertiary cancer center.

Methods: This is a retrospective review of 22 patients treated with SABR for skeletal metastases for oligometastases (OM) or oligoprogression (OP) since October 2012. There are a total of 27 treatments with 20 spinal and seven non-spinal metastases. Read More

J Am Coll Cardiol 2019 Apr 4;73(12):1386-1394. Epub 2019 Mar 4.

Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York; Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Background: Fluorine-18 sodium fluoride (NaF), a bone-seeking radiopharmaceutical used to detect osseous metastases, localizes in regions of microcalcification in atherosclerosis.

Objectives: To determine if atherosclerosis of penile arteries plays a role in erectile dysfunction (ED), this study analyzed NaF images in prostate cancer patients.

Methods: NaF positron emission tomography-computed tomography bone scans were evaluated in 437 prostate cancer patients (age 66. Read More

Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7.

Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Ypsilantou 45-47, PC 106 76, Athens, Greece.

Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Read More

BMC Surg 2019 Mar 4;19(1):30. Epub 2019 Mar 4.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Alveolar soft part sarcoma (ASPS) is an extremely rare neoplasm that tends to occur in the lower limbs of children and adolescents. Metastatic breast tumors constitute 0.5-2. Read More

Clin Nucl Med 2019 May;44(5):414-416

From the Joint Program in Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA; and Department of Imaging, Dana-Farber Cancer Institute, Boston, MA.

Extraosseous Tc-MDP uptake on bone scans is frequently encountered and has a broad differential diagnosis. A small subset of such patients can present with intestinal Tc-MDP uptake. We present the case of a 35-year-old woman with status after right nephrectomy for renal cell carcinoma, being followed with bone scan for osseous metastases. Read More

Clin Nucl Med 2019 Mar 1. Epub 2019 Mar 1.

Marien Gesellschaft, Siegen, Germany.

A 68-year-old man with a metastatic neuroendocrine tumor with unknown primary was found to have partially dedifferentiated metastases according to F-FDG uptake. He received 3 cycles of radiopeptide therapy using [Lu]Lutetium-DOTATATE combined with temozolomide. Before this treatment, the patient had already undergone a series of therapies, including biotherapy, everolimus, 5 cycles of radiopeptide therapies, radiotherapy, and bone-protecting therapy with bisphosphonate and receptor activator of NF-κB ligand, each of which temporarily stalled the progress of the disease. Read More

Radiol Med 2019 Mar 4. Epub 2019 Mar 4.

Radiology Department, Università Politecnica delle Marche, Via Conca 71, 60020, Ancona, Italy.

With the assistance of innovations in scanner engineering and software design, dual-energy computed tomography (DECT) is an advanced imaging method that has been developed over the last decade. With its unique ability to differentiate materials by their atomic number, DECT has opened new perspectives in imaging. The principal advantages of DECT over conventional CT in the musculoskeletal setting relate to the additional information provided regarding tissue composition, artifact reduction and image optimization. Read More

Nucl Med Mol Imaging 2019 Feb 11;53(1):42-46. Epub 2019 Jan 11.

PERFECT Myanmar Molecular Imaging and Therapy center (PERFECT MMITC), No (122/124), 15th street (Middle block), Ward 7, Lanmadaw Township, 11131 Yangon, Myanmar.

Prostate cancer is third common malignancy in men of old age (average 65 years) in Myanmar. Currently, serum PSA and bone scan are the markers of choice. Because of the evidence-based, promising success of Ga-PSMA PET-CT and Lu-PSMA theranostics in prostate cancer worldwide, Tc-PSMA SPECT-CT imaging and Lu-PSMA therapy has launched as a stepping-stone of theranostics in Myanmar with the available facilities. Read More

World J Urol 2019 Mar 2. Epub 2019 Mar 2.

Department of Radiology, Centre Du Cancer and Institut de Recherche Expérimentale Et Clinique (IREC, IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium.

Purpose: It is generally accepted that when metastases develop in a patient with biochemical recurrence of prostate cancer (PCa), they follow a centrifuge pattern of seeding from the pelvis and that most patients enter the disease as oligometastatic. In this study, we used whole-body magnetic resonance imaging (WB-MRI) to assess the anatomical distribution of oligo- and polymetastatic disease and the impact of the initial treatment on this distribution in patients.

Materials And Methods: WB-MRI examinations of patients with a rising prostate-specific antigen (PSA) after radical treatment by surgery or/and radiotherapy were analyzed for disease recurrence. Read More

Clin Orthop Relat Res 2019 Apr;477(4):707-714

C. J. Gutowski, MD Anderson Cancer Center at Cooper, Department of Orthopaedic Surgery, Cooper University Hospital, Camden, NJ, USA C. J. Gutowski, N. Fabbri, P. J. Boland, J. H. Healey, Orthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA B. Zmistowski, Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA N. Fabbri, P. J. Boland, J. H. Healey, Department of Surgery, Weill Cornell Medical College, New York, NY, USA.

Background: Biologic agents may prolong survival of patients with certain kidney and lung adenocarcinomas that have metastasized to bone, and patient response to these agents should be considered when choosing between an endoprosthesis and internal fixation for surgical treatment of femoral metastases.

Questions/purposes: Among patients undergoing surgery for femoral metastases of lung or renal cell carcinoma, (1) Does survival differ between patients who receive only cytotoxic chemotherapy and those who either respond or do not respond to biologic therapy? (2) Does postsurgical incidence of local disease progression differ between groups stratified by systemic treatment and response? (3) Does implant survival differ among groups stratified by systemic treatment and response?

Methods: From our institutional longitudinally maintained orthopaedic database, patients were identified by a query initially identifying all patients who carried a diagnosis of renal cell carcinoma or lung carcinoma. Patients who underwent internal fixation or prosthetic reconstruction between 2000 and 2016 for pathologic fracture of the femur and who survived ≥ 1 year after surgery were studied. Read More

Cell Commun Signal 2019 02 26;17(1):17. Epub 2019 Feb 26.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for application in cancer therapeutic remedies. However, the level of CDK4 and the treatment possibility in chondrosarcoma require further exploration. Read More

Tumori 2019 Feb 24:300891619832521. Epub 2019 Feb 24.

Laboratory Medicine Unit-IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Purpose:: The integration of expertise between oncologist and clinical biochemist for the monitoring and diagnosis of plasma cell dyscrasia is crucial. In some cases, medical laboratory scientists can provide an original contribution using the appropriate techniques to arrive at a diagnosis.

Methods:: We report a case of 67-year-old woman who was admitted to our hospital for bone pain. Read More

J Nucl Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Nuclear Medicine, Shanghai General Hospital, China.

Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed death ligand (PD-L1) antibodies demonstrates improvements in treatment of advanced non-small cell lung cancer (NSCLC). Treatment stratification depends on immunohistochemical PD-L1 measurement of biopsy material, an invasive method that does not account for spatiotemporal heterogeneity. Using a single domain antibody (sdAb), NM-01, against PD-L1, radiolabeled site-specifically with technetium-99m (Tc) for single photon emission computed tomography (SPECT) imaging, we aimed to assess the safety, radiation dosimetry and imaging characteristics of this radiopharmaceutical and correlate tumor uptake with PD-L1 immunohistochemistry results. Read More

J Med Imaging Radiat Sci 2019 Mar 7;50(1):17-23.e1. Epub 2018 Sep 7.

Palliative Radiation Oncology, Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

Background: Palliative radiation therapists (PRTs) have been integrated in varying capacities into outpatient palliative radiation therapy (RT) services across Canada for over 2 decades. At our institution, PRTs have developed an essential role over 11 years within a palliative radiation oncology (PRO) clinic that focuses on integrating symptom management with radiation oncology assessment for palliative RT. PRTs have had direct clinical, technical, research, and administrative involvement as the clinic evolved from a pilot in 2007 supporting one half-day per week to the current model of five full clinical days. Read More

Osteoporos Sarcopenia 2018 Dec 12;4(4):119-127. Epub 2018 Dec 12.

Department of Endocrinology, Key Laboratory of Endocrinology, The National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by hypophosphatemia resulting from decreased tubular phosphate reabsorption, with a low or inappropriately normal level of active vitamin D. The culprit tumors of TIO could produce fibroblast growth factor 23 which plays a role in regulating renal Pi handling and 25-hydroxyvitamin D 1α-hydroxylase activity. Chronic hypophosphatemia could eventually lead to inadequate bone mineralization, presenting as osteomalacia. Read More

Isr Med Assoc J 2019 Feb;21(2):100-104

Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services.

Objectives: To assess the incidence of metastatic spread in consecutive patients with newly diagnosed cancer, and the potential added value of Ga-PSMA PET/CT to the staging imaging algorithm.

Methods: Patients with newly diagnosed intermediate- and high-risk prostate cancer were referred for initial staging by Ga-PSMA PET/CT between May 2016 and April 2017. Read More

Stereotact Funct Neurosurg 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA,

Background: Significant heterogeneity exists in target volumes for postoperative stereotactic radiosurgery (SRS) for brain metastases. A set of contouring guidelines was recently published, and we investigated the impact of deviations.

Methods: Patients (n = 41) undergoing single-fraction Gamma Knife SRS following surgical resection of brain metastases from 2011 to 2017 were retrospectively reviewed. Read More

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

J Mech Behav Biomed Mater 2019 May 30;93:9-22. Epub 2019 Jan 30.

Department of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Italy.

This paper proposes a computational model based on a finite-element formulation for describing the mechanical behavior of femurs affected by metastatic lesions. A novel geometric/constitutive description is introduced by modelling healthy bone and metastases via a linearly poroelastic constitutive approach. A Gaussian-shaped graded transition of material properties between healthy and metastatic tissues is prescribed, in order to account for the bone-metastasis interaction. Read More