Search Our Scientific Publications & Authors

J Pediatr Orthop 2020 Jul 7. Epub 2020 Jul 7.

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Purpose: Chondroblastoma is a benign, but potentially locally aggressive, bone tumor with predilection for the epiphysis of long bones in growing children. Historically, there is a reported 2% risk of lung metastasis, however these cases are mostly in the form of isolated single reports and the vast majority in adults. The purpose of this study was to identify the "true" risk of lung metastases at presentation in skeletally immature patients with a benign chondroblastoma, and therefore revisit the need for routine chest staging. Read More

Int J Surg Case Rep 2020 Jun 22;73:84-89. Epub 2020 Jun 22.

Division of Foot and Ankle Surgery, Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Introduction: The majority of patients with bone sarcoma or an aggressive benign tumor of the toe can be successfully treated by amputation. However, limb-salvage surgery for toe tumors remains challenging.

Presentation Of Case: A 26-year-old female presented with an enlarging mass on her right 5th toe. Read More

Lancet Oncol 2020 Jul 6. Epub 2020 Jul 6.

Developmental Therapeutics Branch, Magnuson Clinical Center, Bethesda, MD, USA.

Background: Cabozantinib is a multikinase inhibitor of MET, VEGFR, AXL, and RET, which also has an effect on the tumour immune microenvironment by decreasing regulatory T cells and myeloid-derived suppressor cells. In this study, we examined the activity of cabozantinib in patients with metastatic platinum-refractory urothelial carcinoma.

Methods: This study was an open-label, single-arm, three-cohort phase 2 trial done at the National Cancer Institute (Bethesda, MD, USA). Read More

Clin Exp Metastasis 2020 Jul 8. Epub 2020 Jul 8.

Sunnybrook Research Institute, Toronto, ON, Canada.

Mechanical instability secondary to vertebral metastases can lead to pathologic vertebral compression fracture (VCF) mechanical pain, neurological compromise, and the need for surgical stabilization. Stereotactic body radiation therapy (SBRT) as a treatment for spinal metastases is effective for pain and local tumor control, it has been associated with an increased risk of VCF. This study quantified computed tomography (CT) based stability measures in metastatic vertebrae with VCF treated with spine SBRT. Read More

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020915989

Department of Orthopedic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China.

Purpose: Evidence on the incidence, prevalence, and outcomes of bone metastases among patients with systemic malignancy is limited. This study aimed to evaluate it using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: We collected patients diagnosed with solid malignant tumors deriving outside of the bone, hematologic malignancies, Kaposi sarcoma, lymphoma, and myeloma from the SEER database (from 2010 to 2013). Read More

Medicine (Baltimore) 2020 Jul;99(27):e20808

Department of Basic Medical Science, the Center of Translational Medicine.

Rationale: Palbociclib (PAL) is a first-in-class selective inhibitor of the cyclin-dependent kinases 4 (CDK4) and CDK6 and is indicated for the treatment of hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) in combination with fulvestrant (FUL) in postmenopausal women. Antrodia cinnamomea (AC), a well-known Chinese folk medicine in Taiwan, possesses numerous biological capabilities, most notably an anti-tumor effect. However, the clinical use of AC as complementary medicine combined with adjuvant therapy is unexplored. Read More

Chem Pharm Bull (Tokyo) 2020 ;68(7):560-566

Department of Biopharmaceutics, Kyoto Pharmaceutical University.

Bone metastases can cause high morbidity and mortality, often developing as they advance, especially in patients with prostate and breast cancers. Most drugs are rarely distributed to the bone and are hence pharmacologically ineffective in treating bone metastases. The development of drug targeting technologies is required for the efficient treatment of bone metastases. Read More

Ann Nucl Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Head and Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: Medullary thyroid cancer (MTC) arises from neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method that can reveal all MTC recurrences or metastases. Ga-DOTATATE is an alternative PET radiotracer that showed acceptable efficacy in the detection of MTC. Read More

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

EJNMMI Res 2020 Jun 29;10(1):71. Epub 2020 Jun 29.

Department of Quantum Medical Technology, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan.

Background: Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstruction using images derived from phantoms and patients.

Methods: A custom-designed body phantom for bone SPECT was scanned using a Symbia Intevo (Siemens Healthineers), and reconstructed xSPECT images were evaluated. Read More

Eur Urol Oncol 2020 Jun 23. Epub 2020 Jun 23.

Genito-Urinary Cancer Research Group, Division of Cancer Sciences, The University of Manchester, Manchester, UK; FASTMAN Centre of Prostate Cancer Excellence, Manchester Cancer Research Centre, Manchester, UK; Department of Surgery, The Christie NHS Foundation Trust, Manchester, UK; Department of Urology, The Salford NHS Foundation Trust, Manchester, UK. Electronic address:

Background: Prostate radiotherapy (RT) is a first-line option for newly diagnosed men with low-burden metastatic prostate cancer. The current criterion to define this clinical state is based on manual bone metastasis counts, but enumeration of bone metastases is limited by interobserver variations, and it does not account for metastasis volume or lesional coalescence. The automated bone scan index (aBSI) is a quantitative method of evaluating bone metastatic burden in a standardised and reproducible manner. Read More

Auris Nasus Larynx 2020 Jun 23. Epub 2020 Jun 23.

Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611 Tokyo, Japan.

Objective: Bone turnover suppression agents are widely used for prophylaxis of bone metastases from cancer and osteoporosis; the occurrence of their side effect, antiresorptive agent-related osteonecrosis of the jaw (ARONJ), has been increasing. We investigated the relationships between opacification in the nasal sinuses, rhinosinusitis, and ARONJ based on data obtained from oral surgeons.

Methods: We examined 132 patients who had been clinically diagnosed with ARONJ based on clinical observations; all patients had undergone treatment at the Departments of Otorhinolaryngology and Oral Surgery. Read More

Skeletal Radiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Oral Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.

Myositis ossificans (MO) is a benign soft-tissue lesion characterized by the heterotopic formation of the bone in skeletal muscles, usually due to trauma. MO is occasionally difficult to diagnose because of its clinical and radiological similarities with malignancy. We report a case of traumatic MO (TMO) in the masseter and brachial muscles of a 37-year-old man who presented with painless swelling in the left cheek and severe trismus. Read More

Ann Nucl Med 2020 Jun 24. Epub 2020 Jun 24.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Objective: This retrospective study investigated the performance of whole-body bone scintigraphy combined with SPECT/CT and established a grading diagnostic criterion for bone metastases.

Methods: We summarized signs of whole-body bone imaging combined with SPECT in nuclear medicine and CT signs of corresponding parts. Then we established a diagnostic criterion for bone metastases by using whole-body bone scintigraphy combined with local SPECT/CT. Read More

Respir Med Case Rep 2020 12;30:101124. Epub 2020 Jun 12.

Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan.

A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Read More

FP Essent 2020 Jun;493:27-29

UNC Orthopaedics, 130 Mason Farm Road CB# 7055, Chapel Hill, NC 27599-7055.

Metastatic bone disease is common, and affects more than 5 million individuals in the United States. Patients may present with bone pain. If a patient is known to have a cancer that commonly spreads to bone (ie, kidney, lung, breast, prostate, thyroid), metastatic bone disease should be considered as a cause. Read More

Clin Orthop Relat Res 2020 Jun 10. Epub 2020 Jun 10.

A. Gulia, V. Kurisunkal, A. Puri, N. Purandare, S. Gupta, V. Rangarajan, Department of Surgical Oncology, Tata Memorial Hospital, HBNI, Mumbai, India.

Background: Staging of a bone sarcoma before initiating treatment helps orthopaedic oncologists determine the intent of treatment and predicting the prognosis. As per National Comprehensive Cancer Network (NCCN) and European Society for Medical Oncology (ESMO) guidelines, there are no exclusive recommendations for chondrosarcoma staging. They are staged similar to other bone sarcomas even though skeletal metastases are extremely rare in chondrosarcomas. Read More

Eur J Nucl Med Mol Imaging 2020 Jun 20. Epub 2020 Jun 20.

Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Purpose: Clinical PET imaging of human epidermal growth factor receptor 2 (HER2) can noninvasively detect HER2 overexpression in lesions. A novel Ga-NOTA-MAL-MZHER2 (Ga-HER2) affibody was developed for clinical PET/CT, and its safety, tissue dosimetry, ability to detect HER2-positive lesions, and utility for HER2-targeted therapy in patients with advanced gastric cancer (AGC) were evaluated.

Methods: Thirty-four patients with AGC (23 with HER2-positive and 11 with HER2-negative primary lesions) were included and underwent PET/CT after an injection of approximately 3. Read More

Surg Case Rep 2020 Jun 19;6(1):143. Epub 2020 Jun 19.

Department of Breast Surgery, Kyoto University Hospital, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Solid papillary carcinoma (SPC) of the breast is a rare breast cancer that accounts for less than 1% of all breast cancers. The optimal clinical management of SPC remains controversial. Here, we report a case of invasive SPC with neuroendocrine differentiation in addition to review of the current literature. Read More

Ann Ital Chir 2020 May 11;9. Epub 2020 May 11.

Hepatocellular carcinoma metastases to the breast have been reported only rarely. A 63-year-old male patient with metastatic hepatocellular carcinoma presented with a lump in his left breast. On physical examination, there was a hard, well-circumscribed, and partially mobile mass of 2 cm in diameter in the lower middle quadrant of the left breast. Read More

Insights Imaging 2020 Jun 16;11(1):79. Epub 2020 Jun 16.

Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, UK.

Numerous imaging modalities may be used for the staging of women with advanced breast cancer. Although bone scintigraphy and multiplanar-CT are the most frequently used tests, others including PET, MRI and hybrid scans are also utilised, with no specific recommendations of which test should be preferentially used. We review the evidence behind the imaging modalities that characterise metastases in breast cancer and to update the evidence on comparative imaging accuracy. Read More

JAMA 2020 06;323(23):2438

Department of Neurosurgery, University of Illinois Hospital and Clinics, Chicago, Illinois.

Eur J Radiol 2020 Aug 6;129:109118. Epub 2020 Jun 6.

Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Purpose: Cholangiocarcinoma (CCA) is the second most common primary malignant hepatic tumor originating from bile duct epithelia. Bone metastasis is uncommon and less documented. The aim of this study was to characterize the imaging features of bone metastasis from CCA. Read More

Radiol Phys Technol 2020 Jun 13. Epub 2020 Jun 13.

Department of Nuclear Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-11 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Metabolic bone volume (MBV), standardized uptake value (SUV), and total bone uptake (TBU) are new imaging biomarkers for quantitative bone single-photon emission computed tomography/computed tomography. The purpose of this study was to validate the quantitative accuracy and utility of MBV, SUV, and TBU for the assessment of bone metastases in prostate cancer. We used a bone-specific phantom with four hot spheres (φ = 13, 17, 22, 28 mm) filled with different Tc-99 m activities to simulate uptake ratios of 3 and 7, corresponding to normal and metastatic values. Read More

Eur Urol 2020 Jun 9. Epub 2020 Jun 9.

Department of Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

The Lu-labeled prostate-specific membrane antigen (LuPSMA) radionuclide therapy for metastatic castration-resistant prostate cancer is under investigation in a phase III trial (VISION: NCT03511664). However, patients with diffuse bone involvement, diagnosed with a "superscan" by bone scintigraphy at baseline, were excluded due to a lack of efficacy and safety data. We therefore aimed to investigate the feasibility of LuPSMA in patients with diffuse bone marrow involvement on baseline PSMA-targeted positron emission tomography. Read More

BJU Int 2020 Jun 12. Epub 2020 Jun 12.

Department of Urology, Uro-Oncology and robot assisted surgery University Hospital of Cologne, Cologne, Germany.

Objective: To investigate the diagnostic performance of 68Ga-PSMA PET/CT in patients with recurrent prostate cancer with regard to the presence of lymph node metastases and local recurrences after primary radiotherapy.

Subject/patients And Methods: We retrospectively reviewed 142 patients following sRPE, 50 of which had a 68Ga-PSMA PET/CT performed as a preoperative staging module. Predictive clinical parameters were analyzed in a multivariate cox regression analysis. Read More

Molecules 2020 Jun 9;25(11). Epub 2020 Jun 9.

Surfactants Research Chair, Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Early diagnosis of bone metastases is crucial to prevent skeletal-related events, and for that, the non-invasive techniques to diagnose bone metastases that make use of image-guided radiopharmaceuticals are being employed as an alternative to traditional biopsies. Hence, in the present work, we tested the efficacy of a gallium-68 (Ga)-based compound as a radiopharmaceutical agent towards the bone imaging in positron emitting tomography (PET). For that, we prepared, thoroughly characterized, and radiolabeled [Ga]Ga-NODAGA-pamidronic acid radiopharmaceutical, a Ga precursor for PET bone cancer imaging applications. Read More

AACE Clin Case Rep 2020 May-Jun;6(3):e135-e140. Epub 2020 May 8.

Objective: Hypercalcemia of malignancy (HCM) is caused by 1 of 5 known mechanisms including systemic release of ectopic parathyroid hormone (PTH)-related protein (PTHrP), calcitriol, PTH, cytokines, or destruction of bone by osteolytic metastases. We report the first case of 2 simultaneous mechanisms for HCM in a patient with a peripheral nerve sheath tumor (PNST).

Methods: PubMed and Google Scholar searches were performed using "hypercalcemia of malignancy" as the search term. Read More

Clin Nucl Med 2020 Jun 8. Epub 2020 Jun 8.

From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China.

A 55-year-old woman with back pain underwent F-NaF PET/CT study to evaluate bone metastases from newly diagnosed breast cancer. Multiple foci of increased tracer uptake indicating osteoblastic metastases were noted in cervical and thoracic vertebrae. Unexpectedly, breast cancer also revealed increased NaF activity. Read More

Skeletal Radiol 2020 Jun 9. Epub 2020 Jun 9.

University of Missouri at Columbia, Columbia, MO, USA.

Solitary fibrous tumors are rare mesenchymal neoplasms of fibroblastic or myofibroblastic origin. Primary solitary fibrous tumors arising in bone are extremely rare and rarely metastasize. We present a case of solitary fibrous tumor where the diagnosis was delayed due to a failure to recognize the subtle, lytic lesion underlying a fracture of the left humerus. Read More

Skeletal Radiol 2020 Jun 9. Epub 2020 Jun 9.

The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD, 21287, USA.

Purpose: To evaluate the prevalence, imaging appearance, and significance of popliteal lymph nodes (PLN) on magnetic resonance imaging (MRI) in patients with distal femoral or proximal tibial osteosarcoma (OS).

Method And Materials: This study included consecutive patients with OS presenting from May 2016 to March 2018. Inclusion criteria were patients with distal femoral or proximal tibial OS with MRI and pathology at our institution. Read More

Neurol Res 2020 Jun 4:1-11. Epub 2020 Jun 4.

Department of Bone Tumor, Tianjin Hospital , Tianjin, China.

Objective: Spinal metastases have unique epidemiological features and treatment methods. Unfortunately, the relative scarcity of spinal metastases has limited the widespread development of descriptive epidemiological studies, especially in Asian countries. The purpose of this study was to describe the epidemiological characteristics of patients with metastatic spinal tumors in China between 2007 and 2019. Read More

Curr Oncol 2020 Apr 1;27(2):e123-e145. Epub 2020 May 1.

Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON.

Background: In Ontario, there is no clearly defined standard of care for staging for distant metastasis in women with newly diagnosed and biopsy-confirmed breast cancer whose clinical presentation is suggestive of early-stage disease. This guideline addresses baseline imaging investigations for women with newly diagnosed primary breast cancer who are otherwise asymptomatic for distant metastasis.

Methods: The medline and embase databases were systematically searched for evidence from January 2000 to April 2019, and the best available evidence was used to draft recommendations relevant to the use of baseline imaging investigation in women with newly diagnosed primary breast cancer who are otherwise asymptomatic. Read More

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):485-488

Department of Rheumatology, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China.

A 28-year-old man was admitted to the first medical center of Chinese People's Liberation Army General Hospital because of multiple myalgia and intramuscular nodules for more than 2 months. The patient complained of dysphagia, fever and weight loss 2 months ago. Magnetic resonance imaging and biopsy revealed nodular fasciitis. Read More

Curr Med Imaging 2020 May 28. Epub 2020 May 28.

Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka. Japan.

Background: BSI calculated from bone scintigraphy using 99mtechnetium-methylene diphosphonate (99mTc-MDP) is used as a quantitative indicator of metastatic bone involvement in bone metastasis diagnosis, therapeutic effect assessment, and prognosis prediction. However, the BONE NAVI, which calculates BSI, only supports bone scintigraphy using 99mTc-MDP.

Aims: We developed a method in collaboration with the Tokyo University of Agriculture and Technology to calculate bone scan index (BSI) employing deep learning algorithms with bone scintigraphy images using 99mtechnetiumhydroxymethylene diphosphonate (99mTc-HMDP). Read More

Curr Med Imaging 2020 ;16(5):565-571

Department of Radiology, Dezhou People's Hospital, Dezhou, Shandong, China.

Prostate cancer is one of the most common cancers in men. This cancer is often associated with indolent tumors with little or no lethal potential. Some of the patients with aggressive prostate cancer have increased morbidity and early deaths. Read More

Adv Exp Med Biol 2020 ;1257:45-53

Pediatric and Taussig Cancer Institutes, Department of Pediatric Hematology, Oncology and BMT, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Although trace amounts of radioactivity are routinely used to detect osteosarcoma, the use of larger therapeutic amounts of radiation is often an unrecognized opportunity to treat metastatic osteosarcoma. This chapter will review a number of approaches to use ionizing radiation in the form of injectable radiopharmaceuticals. Since bone metastases are a common pattern of metastatic spread of cancer in general, a number of bone-seeking radiopharmaceuticals have been developed and FDA approved for treatment of bone metastases. Read More

Diagnostics (Basel) 2020 May 28;10(6). Epub 2020 May 28.

Department of Nuclear Medicine, Copenhagen University Hospital Herlev and Gentofte, DK-2730 Herlev, Denmark.

Background: Inconclusive bone scans are a challenge but there is no consensus about follow-up imaging. We evaluated the use of gallium-labelled prostate-specific membrane antigen (Ga-PSMA) PET/CT if F-sodium fluoride (F-NaF) PET/CT was inconclusive.

Methods: This retrospective study included patients with no previously known bone metastases who had one or more equivocal bone lesions on F-NaF PET/CT and underwent additional Ga-PSMA PET/CT. Read More

Spine J 2020 May 28. Epub 2020 May 28.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Meyer 5-185A, Baltimore, MD 21287, USA. Electronic address:

Background: Current evidence suggests that dual-energy x-ray absorptiometry (DXA) scans, the conventional method defining osteoporosis, is underutilized and, when used, may underestimate patient risk for skeletal fragility. It has recently been suggested that other imaging modalities may better estimate bone quality, such as the magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score which also may assess vertebral compression fracture risk in patients with spine metastases.

Purpose: To evaluate whether VBQ score is predictive of fragility fractures in a population with pre-existing low bone density and at high-risk for fracture. Read More

World Neurosurg 2020 May 28;141:8-13. Epub 2020 May 28.

Department of Plastic and Reconstructive Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Eunpyeong-gu, Seoul, Republic of Korea. Electronic address:

Background: Central nervous system (CNS) solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a soft tissue neoplasm that accounts for <1% of all intracranial tumors. Its growth will be mostly intracranial, usually along the sinuses. We have reported a rare case of direct extracranial extension of CNS SFT/HPC penetrating the frontal bone. Read More

Eur J Nucl Med Mol Imaging 2020 May 26. Epub 2020 May 26.

Department of Nuclear Medicine, Korea Cancer Centre Hospital, Korea Institute of Radiological and Medical Sciences, 75, Nowon-ro, Nowon-gu, Seoul, South Korea.

Purpose: To evaluate the biodistribution of [F]Florastamin, a novel F-labelled positron emission tomography (PET) tracer for prostate-specific membrane antigen (PSMA) for the diagnosis of prostate cancer.

Methods: PET was performed for five healthy controls and 10 patients with prostate cancer at 0, 10, 30, 70, and 120 mins after injecting 370 MBq of [F]Florastamin. The maximum standardised uptake value (SUV) was evaluated in the primary tumour. Read More

Cancer 2020 May 26. Epub 2020 May 26.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: The current study was conducted to investigate the patterns of metastases in men with metastatic prostatic ductal adenocarcinoma (DAC) and recurrence patterns after therapy.

Methods: All patients with a new diagnosis of DAC with de novo metastases and those with localized disease who developed metastases after treatment and were treated at the study institution from January 2005 to November 2018 were included. All patient and tumor characteristics and outcome data were collected. Read More

AJR Am J Roentgenol 2020 May 26:1-9. Epub 2020 May 26.

Mallinckrodt Institute of Radiology, St. Louis, MO.

The objective of this article is to describe evidence-based guidelines for percutaneous minimally invasive imaging-guided thermal ablation of bone metastases. Safe and effective minimally invasive thermal ablation can be performed to achieve pain palliation, local tumor control, or cure in selected subgroups of patients with osseous metastases. Thermal protection strategies should be implemented to minimize the risk of undesired thermal injury. Read More

J Med Imaging Radiat Oncol 2020 May 25. Epub 2020 May 25.

Wesley Medical Imaging, The Wesley Hospital, Auchenflower, Queensland, Australia.

Background: Prostate cancer commonly metastasises to bone and regional lymphatics and more rarely to locations such as the brain, skin and penis. Gallium-68 prostate-specific membrane antigen ( Ga-PSMA) positron emission tomography/computed tomography (PET/CT) has widely become the routine imaging modality for prostate cancer staging and re-staging in Australia. The aim of this study was to retrospectively review all Ga-PSMA PET/CT examinations performed to date at our institution to determine the frequency of penile metastases. Read More

Semin Ultrasound CT MR 2020 Apr 18;41(2):207-221. Epub 2020 Feb 18.

Department of Abdominal Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Prostate cancer (PCa) is the most common noncutaneous malignancy in men and the second leading cause of cancer related death in the United States. Men with clinical suspicion of PCa undergo tissue sampling and based on features including the Gleason score, Prostate Specific antigen (PSA) levels and clinical tumor (T) stage, patients are risk stratified into 6 major groups based on National Comprehensive Cancer Network (NCCN) guidelines. This forms the basis for deciding imaging and management. Read More

Eur J Nucl Med Mol Imaging 2020 May 18. Epub 2020 May 18.

Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.

Purpose: Prostate cancer (PCa) commonly metastasizes to the bones. There are several radionuclide techniques for imaging PCa skeletal metastases. We aimed to compare the lesion detection rate of [Ga]Ga-PSMA-11 PET/CT, [Ga]Ga-NODAGA-zoledronate ([Ga]Ga-NODAGA) PET/CT, and [Tc]Tc-MDP bone scan in the assessment of bone metastases in patients with advanced PCa. Read More

Am J Nucl Med Mol Imaging 2020 15;10(2):106-118. Epub 2020 Apr 15.

Center of Urology, Pauls Stradins Clinical University Hospital Riga, Latvia.

Anatomical and functional imaging plays a decisive role for detection and staging, of prostate cancer both primarily and post-treatment. While multiparametric MRI offers anatomic imaging with excellent soft tissue contrast, hybrid imaging based on positron emission tomography in combination with computed tomography (PET/CT) contributes functional imaging capacities. Since Ga-PSMA-11 was expected to be more efficient than the prior Choline-based PET radiotracers, it was the aim of the study to evaluate the diagnostic performance of the Ga-PSMA-11 PET/CT and multiparametric MRI in patients with recurrent prostate cancer and low PSA levels. Read More

J Neurooncol 2020 Jun 15;148(2):381-388. Epub 2020 May 15.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

Introduction: Stereotactic radiosurgery (SRS) has shown durable local control for the treatment of metastatic diseasespinal metastases. Multilevel disease or epidural or paraspinal involvement present challenges to achieving local control, and this study aims to analyze treatment outcomes for such lesions.

Methods: Patients treated at a single institution with SRS to the spine from 2010-2018 were retrospectively reviewed. Read More

Radiologe 2020 Jun;60(6):498-505

Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

Background: Pathologic fractures are fractures that occur without an adequate traumatic event due to focal benign or malignant skeletal lesions. The most common causes of pathologic fractures are cystic bone lesions, plasmocytoma or multiple myeloma, and the development of osseous metastases, which is increasing due to an aging general population and advances in cancer treatment. The differentiation of pathologic fractures from stress fractures, especially osteoporotic insufficiency fractures is crucial for correct treatment planning. Read More

Eur J Nucl Med Mol Imaging 2020 May 13. Epub 2020 May 13.

Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Purpose: First-line treatment of patients with recurrent, metastatic prostate cancer involves hormone therapy with or without additional systemic therapies. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) allows the detection of oligometastatic disease that may be amenable to image-guided radiotherapy. The current study classifies the type and localization of metastases and the clinical outcome of PSMA-PET/CT-guided radiotherapy to selected metastases. Read More