Search Our Scientific Publications & Authors

Stereotact Funct Neurosurg 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia,

Background: Significant heterogeneity exists in target volumes for postoperative stereotactic radiosurgery (SRS) for brain metastases. A set of contouring guidelines was recently published, and we investigated the impact of deviations.

Methods: Patients (n = 41) undergoing single-fraction Gamma Knife SRS following surgical resection of brain metastases from 2011 to 2017 were retrospectively reviewed. Read More

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

J Mech Behav Biomed Mater 2019 Jan 30;93:9-22. Epub 2019 Jan 30.

Department of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Italy.

This paper proposes a computational model based on a finite-element formulation for describing the mechanical behavior of femurs affected by metastatic lesions. A novel geometric/constitutive description is introduced by modelling healthy bone and metastases via a linearly poroelastic constitutive approach. A Gaussian-shaped graded transition of material properties between healthy and metastatic tissues is prescribed, in order to account for the bone-metastasis interaction. Read More

Clin Cancer Res 2019 Feb 7. Epub 2019 Feb 7.

Radiology, Baylor College of Medicine.

Purpose: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (RaCl) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers.

Experimental Design: A 3+3 phase I, dose-escalation trial of RaCl (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years. Read More

Insights Imaging 2019 Feb 6;10(1):14. Epub 2019 Feb 6.

Department of Interventional Radiology, Nouvel Hôpital Civil (Hôpitaux Universitaires de Strasbourg), 1 Place de l'Hôpital, 67000, Strasbourg, France.

Patients with cancer can present with bone metastases (BM), which are frequently complicated by different types of fractures necessitating prompt management to avoid serious impairment in terms of quality of life and survival.Percutaneous image-guided bone consolidation has rapidly emerged as an alternative to surgical fixation and is mainly reserved for patients who are deemed unfit for surgical management. Two percutaneous techniques, osteoplasty and osteosynthesis, are available and are selected based on the biomechanics of the target bones as well as the fracture types. Read More

Pediatr Blood Cancer 2019 Feb 5:e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

Radiol Clin North Am 2019 Mar 10;57(2):377-395. Epub 2018 Dec 10.

RadNet, 5 Columbus Circle 9th Floor, New York, NY 10019, USA.

Osseous metastases are the most common spine tumor and increasingly prevalent as advances in cancer treatments allow patients to live longer with their disease. Evidence-based algorithms derive the majority of their data from imaging studies and reports; the radiologist should understand the most current treatments and report in the language of the treatment team for efficient and effective communication and patient care. Advanced imaging techniques such as diffusion-weighted imaging and dynamic contrast-enhanced MRI are increasingly used for diagnosis and problem solving. Read More

Med Oncol 2019 Feb 1;36(3):26. Epub 2019 Feb 1.

Department of Oncology, University of Calgary, Tom Baker Cancer Centre, 1331 29 ST NW, Calgary, AB, T2N 4N2, Canada.

This analysis aims to evaluate the performance characteristics of alternative baseline imaging thresholds in a cohort of hepatocellular carcinoma (HCC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. HCC patients within the SEER database (2010-2015) who had complete information on clinical T and N stages as well as complete information on metastatic sites were eligible for the current study. Various performance characteristics associated with baseline imaging were investigated, including specificity, sensitivity, positive likelihood ratio (LR), negative LR, number needed to investigate (NNI), negative predictive value (NPV), positive predictive value (PPV), and accuracy. Read More

Diagn Interv Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Institut de Recherche expérimentale et Clinique (IREC), cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium. Electronic address:

Purpose: To assess the distribution of bone lesions in patients with prostate cancer (PCa) and those with multiple myeloma (MM) using whole-body magnetic resonance imaging (MRI); and to assess the added value of four anatomical regions located outside the thoraco-lumbo-pelvic area to detect the presence of bone lesions in a patient-based perspective.

Materials And Methods: Fifty patients (50 men; mean age, 67±10 [SD] years; range, 59-87 years) with PCa and forty-seven patients (27 women, 20 men; mean age, 62.5±9 [SD] years; range, 47-90 years) with MM were included. Read More

Eur Radiol Exp 2019 Jan 30;3(1). Epub 2019 Jan 30.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Schweitzer-Allee 23, 89081, Ulm, Germany.

Background: Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours.

Methods: Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm) in addition to standard sequences. Read More

Oncotarget 2018 Dec 28;9(102):37676-37688. Epub 2018 Dec 28.

Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.

Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of F-NaF PET/CT and F-PSMA-targeted PET/CT within prostate cancer bone metastases.

Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT (F-DCFBC or F-DCFPyL) and F-NaF PET/CT. Read More

Oncologist 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Background: The 8th edition of TNM staging of non-small cell lung cancer (NSCLC) has revised M classification and defined M1b disease with single extrathoracic metastasis, which is distinguished from M1c with multiple extrathoracic metastases. We investigated the prevalence, characteristics, and overall survival (OS) of M1b disease in patients with stage IV NSCLC.

Methods: The study reviewed the medical records and imaging studies of 567 patients with stage IV NSCLC to determine M stage using the 8th edition of TNM staging. Read More

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

A 76-year-old man presented with recently diagnosed prostate adenocarcinoma, Gleason score of 4 + 4, and a Super bone scan with concurrent PSA of 1.7 ng/mL. Approximately 3. Read More

J Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Theranostics Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik, Bad Berka, Germany.

Lu-labelled prostate-specific membrane antigen (PSMA) radioligand therapy using PSMA-617 and PSMA-I&T ligands (Lu-PRLT) is an emerging treatment in metastatic castration resistant prostate cancer (mCRPC). This retrospective study evaluates clinical outcomes of Lu-PRLT in taxane chemotherapy pretreated (T-pretreated) and taxane chemotherapy naïve (T-naïve) patients with mCRPC. A retrospective analysis was performed on 167 patients with mCRPC who underwent Lu-PRLT between March-2013 and December-2016. Read More

ACS Appl Mater Interfaces 2019 Feb 7. Epub 2019 Feb 7.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in University of Shandong , Yantai University , Yantai 264005 , PR China.

This study aimed to develop an efficient step-by-step osteosarcoma (OS)-targeting liposome system functionalized with a redox-cleavable, bone- and cluster of differentiation 44 (CD44)-dual-targeting polymer. Furthermore, the effect of coadministration of a tumor-penetrating peptide, internalizing RGD (iRGD), was investigated. First, a bone-targeting moiety, alendronate (ALN), was conjugated with hyaluronic acid (HA), a ligand for CD44. Read More

Ann Biomed Eng 2019 Jan 23. Epub 2019 Jan 23.

Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada.

Metastasis of cancer to the spine impacts bone quality. This study aims to characterize vertebral microdamage secondary to metastatic disease considering the pattern of damage and its relationship to stress and strain under load. Osteolytic and mixed osteolytic/osteoblastic vertebral metastases were produced in athymic rats via HeLa cervical or canine Ace-1 prostate cancer cell inoculation, respectively. Read More

AJR Am J Roentgenol 2019 Feb 12;212(2):402-410. Epub 2018 Dec 12.

1 Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628.

Objective: The purpose of this study was to evaluate the sensitivity, tumor conspicuity, and image quality of different material decomposition images of phantoms and patients with nearly isodense bone metastases using rapid-kilovoltage-switching dual-energy CT (DECT).

Materials And Methods: Fifty-one semianthropomorphic lumbar spine phantoms embedded with 75 simulated tumors were scanned without and with outer torso-attenuating encasement under the same scan settings. Two radiologists independently reviewed the 70-keV virtual monochromatic and material decomposition images (hydroxyapatite-water, water-hydroxyapatite, cortical bone-water, water-cortical bone). Read More

Rev Esp Med Nucl Imagen Mol 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Soonchunhyang University Cheonan Hospital, 23-20 Byeongmyeong-dong, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, República de Corea.

We report the case of a breast cancer patient in whom a two-phase F-sodium-fluoride (F-NaF) bone PET/CT was useful for detecting hidden bone metastases and assessing treatment response. The patient underwent a two-phase bone PET/CT to evaluate a newly developed lesion found on bone scintigraphy following surgery. In the perfusion and bone phase PET/CT images, focally increased perfusion and bony uptake were found in the sacrum and L5 vertebra, suggesting bone metastases of breast cancer. Read More

Crit Rev Oncol Hematol 2019 Jan 2;133:33-44. Epub 2018 Nov 2.

Edinburgh Palliative and Supportive Care Group, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address:

Introduction: Cancer frequently spreads to bone, causing cancer-induced bone pain (CIBP) which affects quality of life. The best treatment is radiotherapy (XRT), but response is variable. The aim of this systematic review was to identify factors that predict analgesic response. Read More

Plast Reconstr Surg Glob Open 2018 Dec 12;6(12):e2019. Epub 2018 Dec 12.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University Medical Center, Stanford, Calif.

Background: Incidentalomas are lesions found coincidentally during examination, imaging, or surgical procedures. Preoperative computed tomography angiography (CTA) before abdominal flap harvest for breast reconstruction can lead to identification of incidentalomas leading to the need for further investigations. The aim of this study was to examine the prevalence of incidental findings on preoperative CTA and to determine their impact on management. Read More

J Nucl Med 2019 Jan 17. Epub 2019 Jan 17.

Radboud university medical center, Netherlands.

The aim of this study was to compare the PSMA-targeting characteristics of PSMA-11, radiolabeled based on chelation of F-AlF, to those of Ga-PSMA-11 to image PSMA-expressing xenografts with PET/CT. Labeling of F-AlF-PSMA-11 via F-AlF-complexation was performed as described by Boschi et al. and Malik et al. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14198

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Metastatic thymic carcinoma in the spine is a rare disease with no standard curative managements yet. The objective of this study is to report a very rare case of spinal metastases of thymic carcinoma successfully operated by combination of instrumentation and cement augmentation together with adjuvant treatment. The management of these unique cases has yet to be well-documented. Read More

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

J Radiol Case Rep 2018 Aug 31;12(8):17-24. Epub 2018 Aug 31.

Department Of Radiology, American University Of Beirut Medical Center, Beirut, Lebanon.

Bone metastasis to the hands and feet, known as acrometastasis, is a very rare finding and tends to be associated with extensive metastasis. We herein report the case of a 14-year-old girl known to have a history of successfully treated Ewing's sarcoma arising from the ribs, who presented with a pathologically proven isolated metastatic lesion to the talus 7 years after achieving clinical and radiologic remission. We describe the imaging findings on MRI, CT scan and PET-CT. Read More

Clin Radiol 2019 Mar 14;74(3):196-206. Epub 2019 Jan 14.

The First School of Clinical Medicine, Nanjing Medical University, Nanjing, 210029, Jiangsu, China; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China. Electronic address:

Aim: To assess the diagnostic performance of combined F-fluoride positron-emission tomography (PET)/computed tomography (CT) in bone metastases (BM) and explore whether there is an added value when compared with Tc- methylene diphosphonate (MDP) planar bone scintigraphy (BS).

Materials And Methods: PubMed, EMBASE, Web of Science, and the Cochrane Library were searched to December 2017. Studies evaluating the performance of F-fluoride PET/CT in BM detection and using histopathology or clinical/imaging follow-up for ≥6 months as the reference standard were included. Read More

Radiol Case Rep 2019 Mar 4;14(3):390-395. Epub 2019 Jan 4.

Department of Radiology, Northwell Health System, Lenox Hill Hospital, 100 East 77th St, New York, NY 10075 USA.

Primary splenic angiosarcoma carries a poor prognosis and is among the rarest forms of malignancy. An overwhelming majority of patients with splenic angiosarcoma will develop metastases. However, osseous metastatic disease is rare. Read More

Contrast Media Mol Imaging 2018 9;2018:9840962. Epub 2018 Dec 9.

Department of Experimental Medicine and Surgery, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.

The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of 18F-choline evaluated by PET/CT analysis. To this end, prostate biopsies ( = 110) were collected comprising 44 benign lesions and 66 malignant lesions. Malignant lesions were further subdivided into two groups: biopsies from patients that had clinical evidence of bone metastasis (BM+, = 23) and biopsies from patients that did not have clinical evidence of bone metastasis within 5 years (BM-, = 43). Read More

Clin Nucl Med 2019 Mar;44(3):257-258

From the Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center Houston, TX.

A 32-year-old man with a pancreatic neuroendocrine tumor and known liver metastasis presented with diffuse back pain. Workup octreoscan showed newly developed diffuse bone metastases, in addition to the persistent liver metastases. The bone metastases were later confirmed on MRI spine images. Read More

Clin Nucl Med 2019 Mar;44(3):232-233

From the Departments of Nuclear Medicine and.

Iliac artery angiosarcoma is rare, and bone metastasis as its presenting initial symptom is extremely rare. A 67-year-old man with a history of low back pain presented with multiple MRI-identified lumbar and sacrum lesions highly suggestive of bone metastasis. On subsequent PET/CT scan, in addition to multiple vertebrae and pelvis hypermetabolism, a lesion with intense focal uptake was discovered within the lumen of left common iliac artery. Read More

J Comp Eff Res 2019 Feb 9;8(3):157-163. Epub 2019 Jan 9.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Aim: This study aims at evaluating the performance of some of the imaging recommendations of the National Comprehensive Cancer Network (NCCN) for initial evaluation of bladder cancer.

Methods: Surveillance, epidemiology and end results program (2010-2015) was queried and patients with clinically (T1-T4) bladder cancer and complete information about clinical T/N (tumor/nodal) stage and metastatic sites were extracted. The following characteristics were evaluated in the current analysis: sensitivity, specificity, number needed to investigate (NNI), positive predictive value (PPV), negative predictive value and accuracy. Read More

Orthopade 2019 Jan 8. Epub 2019 Jan 8.

Department of Bone and Joint, The First Hospital of Jilin University, 72 Xinmin Street, 130021, Changchun, Jilin, China.

Clear cell sarcoma (CCS) is a rare soft tissue tumor derived from neural crest cells. It accounts for 1% of all soft tissue sarcomas and usually involves the tendons and aponeuroses in the distal ends of the extremities. The foot and the ankle are the most common primary sites. Read More

Int J Spine Surg 2018 Dec 21;12(6):673-679. Epub 2018 Dec 21.

Diagnostic and Interventional Radiology, IRCCS Instituto Ortopedico Rizzoli, Bologna, Italy.

Background: We performed a retrospective evaluation of histological and imaging results of patients submitted to computed tomography (CT)-guided biopsy for vertebral fractures (VFs) of unknown etiology to evaluate the pathological causes of fractures and also to observe the diagnostic results of imaging studies available.

Methods: We retrospectively reviewed all the CT-guided vertebral biopsies performed in our institution in the last 2 years, selecting patients with VF of unknown etiology. We reviewed clinical records, imaging studies, and histological examination results. Read More

Int J Colorectal Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Street Shapingba District, Chongqing, 400038, China.

Purpose: To investigate the incidence and the associated factors for bone metastases (BM) development and prognosis in initial colorectal cancer (CRC) with a large sample using Surveillance, Epidemiology, and End Results (SEER) cohort.

Methods: Primary CRC patients, who were initially diagnosed between 2010 and 2015 in the SEER database, were included to analyze BM incidence and risk factors for BM occurrence. The patients with at least 1-year follow-up were involved to investigate the prognostic factors for BM. Read More

Eur Urol 2019 Jan 4. Epub 2019 Jan 4.

Department of Thoracic Surgery, Scientific Institute and University Vita-Salute San Raffaele Hospital, Milan, Italy.

The introduction of novel imaging approaches for recurrent prostate cancer (PC) has paved the way for the use of nonsystemic approaches in patients with recurrent disease. While use of surgery or radiotherapy is standard for men with nodal or bone recurrence only, there are no significant data on the possible curative role of surgery for pulmonary metastases. We aimed to assess the efficacy of lung resection in patients with isolated pulmonary recurrence after radical prostatectomy (RP) for clinically localized PC. Read More

Ann Nucl Med 2019 Jan 3. Epub 2019 Jan 3.

Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Objective: Somatostatin receptors are highly expressed in neuroendocrine tumors, and many radiolabeled somatostatin analogs for diagnosis and treatment have been developed. To simultaneously detect not only primary cancer but also bone metastases, this study aimed to develop a positron emission tomography probe using generator-produced nuclide Gallium-68 (T = 68 min), in which a carrier for primary cancer, a carrier for bone metastases lesions, and a stable gallium complex are introduced into the one molecule. Based on this strategy, the somatostatin receptor-targeted peptide, [Tyr]-octreotate (TATE), aspartic acid peptide (D) with high binding affinity for hydroxyapatite, and Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) as a stable gallium complex were selected. Read More

PLoS One 2019 2;14(1):e0209293. Epub 2019 Jan 2.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.

Background: Population-based estimates of the incidence and prognosis of brain metastases at diagnosis of hepatocellular carcinoma (HCC) are lacking. The aim of this study was to characterize the incidence proportion and survival of newly diagnosed hepatocellular carcinoma with brain metastases (HCCBM).

Materials And Methods: Data from Surveillance, Epidemiology, and End Results (SEER) program between 2010 and 2014 was evaluated. Read More

World J Surg Oncol 2018 Dec 28;16(1):241. Epub 2018 Dec 28.

Balgrist University Hospital, Forchstrasse 340, 8008, Zurich, Switzerland.

Background: Radiation therapy is an important therapeutic element in musculoskeletal tumours, especially when encountering multiple or painful lesions. In osteolytic lesions, a surgical stabilization with implants is often required. However, metallic implants not only complicate the CT-based planning of a subsequent radiation therapy, but also have an uncontrollable dose-modulating effect in adjuvant radiotherapy. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13808

Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China.

This study aims to analyze and summarize the imaging features of spinal atypical teratoid/rhabdoid tumors (AT/RT) in children.Imaging features in 8 children with spinal AT/RT confirmed by surgical pathology were retrospectively analyzed. All patients had underwent total spine 3. Read More

Clin Med Res 2018 Dec;16(3-4):69-72

Department of Hematology/Oncology, Marshfield Clinic, Weston, Wisconsin, USA

A man, aged 61 years, with a history of hypogonadism and family history of cancer experienced persistent urinary difficulties with no visible prostate abnormalities. Laboratory testing and diagnostic imaging revealed a primary lesion in the prostate with lymph node involvement and multiple bone metastases. Treatment with androgen-deprivation therapy, 17,20-lyase inhibition, and bisphosphonates for 7 months was unsuccessful in preventing disease progression, but second-line chemotherapy and continued androgen-deprivation therapy improved prostate specific antigen levels. Read More

Transplant Direct 2018 Dec 23;4(12):e408. Epub 2018 Nov 23.

Liver Transplant Unit, Austin Health, Melbourne, Victoria, Australia.

Background: The purpose of this study was to review the value of bone scans (BS) in the assessment of bone metastases from early-stage hepatocellular carcinoma (HCC) in patients assessed or waiting for liver transplant (LTx).

Methods: We reviewed BS studies performed at our center for patients with early-stage HCC either being assessed for LTx, or on the waiting list for LTx, from January 2010 to May 2017. The BS findings were classified as positive, equivocal, or negative. Read More

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Department of Respiratory and Sleep Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

A healthy 31-year-old man presenting with back pain was found to have multiple spinal enhancing lesions on MRI. An incidental asymptomatic large pleural effusion was identified on investigations for the back pain and pleural and pulmonary tuberculosis (TB) was subsequently diagnosed. The radiographical features on MRI spine were not typical of spinal TB and a Ga68 DOTATATE Positron Emission Tomography (PET)/CT confirmed metastatic paraganglioma with multiple bone metastases. Read More

Urology 2018 Dec 21. Epub 2018 Dec 21.

University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA; Department of Radiology, San Francisco VA Medical Center, San Francisco, CA. Electronic address:

Objective: To evaluate the impact of staging Ga-PSMA-11 PET imaging on radiotherapy (RT) dose and volumes in patients with prostate cancer.

Methods: Forty-five patients (89% high or very high risk by NCCN criteria) who underwent Ga-PSMA-11 PET imaging prior to definitive treatment for prostate cancer between December 2015 and December 2016 were included. Locations of Ga-PSMA-11-avid lesions were compared to Radiation Therapy Oncology Group consensus pelvic nodal volumes (clinical target volume [CTV]); coverage of lesions outside the consensus CTV was considered a major change, while dose-escalation to lesions within the consensus CTV was considered a minor change. Read More

Proc Natl Acad Sci U S A 2019 Jan 21;116(2):631-640. Epub 2018 Dec 21.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215;

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Read More

Arch Soc Esp Oftalmol 2018 Dec 18. Epub 2018 Dec 18.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

Two clinical cases of orbital metastasis are presented. The first is a 63 year-old male with a recent loss of visual acuity associated with binocular diplopia. Neuroimaging tests revealed a tumour of aggressive features with intraconal extension and bone invasion. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13796

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Malignant thymoma in the spine is a rare disease without standard curative managements so far. The objective of this article is to report a very rare case of recurrent malignant thymoma with sacrum metastases causing severe lumbosacral pain, which was presented with acute radiculopathy and treated with 2 operations combined with stabilization and cement augmentation. The management of these unique cases is not well-documented. Read More

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Otolaryngology/HNS, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.

Salivary duct carcinoma (SDC) is a rare and extremely aggressive salivary gland cancer. An 81-year-old woman with SDC underwent a total parotidectomy with facial nerve sacrifice and a neck dissection. Following surgery, she was diagnosed with disseminated bone marrow metastases. Read More

Global Spine J 2018 Dec 19;8(8):866-871. Epub 2018 Apr 19.

Galway University Hospitals, Galway, Republic of Ireland.

Study Design: Literature review.

Objectives: Metastatic disease affecting the craniovertebral junction (CVJ) only accounts for 0.5% of all spine metastases. Read More

PLoS One 2018 17;13(12):e0208860. Epub 2018 Dec 17.

Department of Orthopedic Surgery, The Catholic University of Korea, Seocho-gu, Seoul, South Korea.

Background: Metastasis and multiple myeloma are common malignant bone marrow lesions which may be difficult to distinguish because of similar imaging findings. The purpose of this study was to determine the value of adding diffusion-weighted imaging (DWI) to standard MR imaging to differentiate multiple myeloma from metastasis.

Methods: 25 patients with metastasis and 18 patients with multiple myeloma underwent 3T MR imaging with DWI (b = 0, 800 s/mm2) were enrolled. Read More

Radiol Med 2018 Dec 15. Epub 2018 Dec 15.

S. C. Radioterapia, ASST dei Sette Laghi-Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Aims: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy.

Methods And Study Design: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. Read More