2,938 results match your criteria Imaging in Bacterial Meningitis

Diagnostic Value of Radioisotope Cisternography Using In-DTPA in a Patient with Rhinorrhea and Purulent Meningitis.

Medicina (Kaunas) 2022 May 26;58(6). Epub 2022 May 26.

The Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, 04011 Kosice, Slovakia.

Cerebrospinal fluid (CSF) leakage is a rare condition. Prompt diagnosis and early treatment of CSF leakage minimizes the risk of severe complications such as bacterial meningitis. Different diagnostic modalities are used to detect the site of CSF leakage but often with unreliable results. Read More

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Intracranial complications of hypercoagulability and superinfection in the setting of COVID-19: illustrative cases.

J Neurosurg Case Lessons 2022 May 23;3(21):CASE22127. Epub 2022 May 23.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Hypercoagulability with thrombosis and associated inflammation has been well-documented in COVID-19, and catastrophic cerebral venous sinus thromboses (CVSTs) have been described. Another COVID-19-related complication is bacterial superinfection, including sinusitis. Here, the authors reported three cases of COVID-19-associated sinusitis, meningitis, and CVST and summarized the literature about septic intracranial thrombotic events as a cause of headache and fever in COVID-19. Read More

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Value of CSF-Cl, CSF-GS, CSF-MALB, and CSF-ADA in Differential Diagnosis of Secondary Hydrocephalus.

Contrast Media Mol Imaging 2022 28;2022:6742795. Epub 2022 May 28.

Department of Neurosurgery, Guangdong Medical University, Zhanjiang City, Guangdong Province, China.

Objectives: To investigate the value of cerebrospinal fluid chloride (CSF-Cl), cerebrospinal fluid glucose (CSF-GS), cerebrospinal fluid microalbumin (CSF-MALB), and cerebrospinal fluid adenosine deaminase (CSF-ADA) in the differential diagnosis of secondary hydrocephalus.

Methods: 103 patients with secondary hydrocephalus treated in our hospital from January 2018 to April 2022 were selected. According to different types, it is divided into the hemorrhagic hydrocephalus group and tumor hydrocephalus group. Read More

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Community-Acquired Meningitis Complicated by Pyogenic Ventriculitis: A Case Report.

Cureus 2022 Apr 7;14(4):e23907. Epub 2022 Apr 7.

Neurology, Sisters of St. Mary (SSM) Health DePaul Hospital, St. Louis, USA.

Ventriculitis is the inflammation of the ependymal lining of the ventricles in the brain which usually occurs as a complication of meningitis, intraventricular devices, intracranial surgery, or brain abscess. Common clinical features include fever, altered mental status, headache, and neck rigidity. Some commonly associated organisms are gram-negative , , and Here, we report the case of a 57-year-old female presenting with fever, headache, and altered mental status, along with positive physical examination findings of Kernig's and Brudzinski's signs without any focal neurological deficits. Read More

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Tuberculous Skull Base Osteomyelitis With Cerebral Venous Sinus Thrombosis in an Immunocompetent Adolescent: A Case Report.

Cureus 2022 Apr 6;14(4):e23865. Epub 2022 Apr 6.

General Medicine, All India Institute of Medical Sciences, Raipur, IND.

Skull-base osteomyelitis is a rare yet lethal entity. It is infrequently observed among immunocompetent children and young adults, and Mycobacterium is much less common among the various bacterial and fungal etiological causes noted. We report a rare case of a 17-year immunocompetent girl who presented with complaints of head and neck pain and restricted neck movements. Read More

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Pearls & Oy-sters: Diagnosis and Subtyping of Listeria Ventriculitis in an Immunocompetent Host.

Neurology 2022 May 4. Epub 2022 May 4.

Department of Neurology, Kunming Medical University, Yunnan, China

is a gram-positive food-borne pathogen that causes gastrointestinal symptoms and central nervous system (CNS) infection in susceptible hosts.. Two lineages of cause the majority of neurolisteriosis in humans. Read More

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Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.

Nat Neurosci 2022 May 2;25(5):567-576. Epub 2022 May 2.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid (CSF), which interfaces with the glymphatic system and thereby drains the brain's interstitial and perivascular spaces, facilitates outward signaling beyond the blood-brain barrier. Read More

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Septic cavernous sinus thrombosis after minor head trauma: A case report.

Medicine (Baltimore) 2022 Mar 11;101(10):e29057. Epub 2022 Mar 11.

Department of Neurology, Chonnam National University Medical School & Hospital, Gwangju, South Korea.

Rationale: Septic cavernous sinus thrombosis (SCST) is a rare but life-threatening condition that commonly arises from infections, including paranasal sinusitis, otitis media, and skin infection. Meanwhile, head trauma as a predisposing factor of SCST has been scarcely reported. We report a case of SCST complicated by meningitis after minor head trauma, even in the absence of identifiable fractures. Read More

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Cochlear implantation after deafness from meningitis.

BMJ Case Rep 2022 Apr 15;15(4). Epub 2022 Apr 15.

Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

A woman in her late 40s who works as a veterinary technician represented to the emergency department with increasing headache, confusion, neck stiffness, subjective fevers and distorted hearing 2 days after diagnosis of viral infection at an outside emergency department.Diagnosis of was made from blood cultures and lumbar puncture. Intravenous ceftriaxone was administered for 21 days. Read More

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Clinical Efficacy of Dexamethasone in the Treatment of Patients with Tuberculous Meningitis: A Meta-Analysis.

Contrast Media Mol Imaging 2022 30;2022:2180374. Epub 2022 Mar 30.

Department of Neurology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750002, China.

Objective: This study aimed to systematically evaluate the clinical efficacy of dexamethasone in patients with tuberculous meningitis (TBM) through meta-analysis.

Method: PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and the Wanfang Databases were searched, and all relevant Chinese and English literature from 2000 to 2021 were retrieved from each database. We collected randomized controlled trials of conventional antituberculosis drugs combined with dexamethasone treatment (treatment group) and conventional antituberculosis drug treatment or combined with placebo treatment (control group) in TBM patients. Read More

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Waterhouse-Friderichsen Syndrome with Bilateral Adrenal Hemorrhage Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia in an Adult Patient with History of Intravenous Drug Use.

Thomas Kalinoski

Am J Case Rep 2022 Apr 14;23:e936096. Epub 2022 Apr 14.

Department of Internal Medicine, Olive View - UCLA Medical Center, Sylmar, CA, USA.

BACKGROUND Waterhouse-Friderichsen syndrome, also known as acute adrenal insufficiency due to adrenal gland hemorrhage, is an uncommon and frequently fatal condition classically presenting with fever, shock, rash, and coagulopathy. Although most often associated with Meningococcemia, many other etiologies have been implicated, including reports of Staphylococcus aureus infection on autopsy examinations. This report details an adult intravenous drug user with adrenal hemorrhage associated with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Read More

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Spinal canal infection caused by Streptococcus suis in human: a case report.

BMC Infect Dis 2022 Apr 12;22(1):369. Epub 2022 Apr 12.

Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Background: Streptococcus suis is an emerging zoonotic pathogen that mainly causes meningitis, sepsis, arthritis, endocarditis, and endophthalmitis in human. To the best of our knowledge, Spinal canal infection caused by Streptococcus suis has rarely been reported.

Case Presentation: Here we report a case of spinal canal infection caused by Streptococcus suis in a 50-year-old male patient. Read More

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Pott Puffy Tumor Caused by Dental Infection: A Case Report and Literature Review.

J Craniofac Surg 2022 Mar-Apr 01;33(2):e127-e130

Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, South Korea.

Abstract: Pott puffy tumor (PPT), first described by Sir Percivall Pott in 1760, is a rare clinical entity characterized by a subperiosteal abscess associated with osteomyelitis of the frontal bone caused by direct or hematogenous spread. Although rare in this modern age of antibiotics, this tumor usually occurs as a complication of sinusitis. Moreover, intracranial complications such as subdural abscess, meningitis, sinus thrombosis, or brain abscess can occur concomitantly with the underlying sinusitis, despite the administration of antibiotics. Read More

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Emergency department management of adults with infectious meningitis and encephalitis.

Emerg Med Pract 2022 04 2;24(4):1-24. Epub 2022 Apr 2.

Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

Infectious meningitis and encephalitis are often life-threatening illnesses, though prompt workup and targeted treatment can greatly reduce morbidity and mortality. Although presentation of central nervous system infection can sometimes be subtle, this issue focuses on evidence-based strategies for identifying combinations of signs and symptoms to narrow the diagnosis. Identifying meningitis versus encephalitis; bacterial versus viral, fungal, or iatrogenic causes; and providing prompt empiric antimicrobials and appropriate diagnostic testing are key to management. Read More

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A Retrospective Study of Recurrent Bacterial Meningitis in Children: Etiology, Clinical Course, and Treatment.

Comput Math Methods Med 2022 10;2022:3681871. Epub 2022 Mar 10.

Department of Neurology, Children's Hospital of Hebei, Shijiazhuang 050031, China.

Objectives: Recurrent bacterial meningitis (RBM) is a rare but life-threatening disease. This study aims to analyze the clinical features, potential causes, and therapeutic outcomes of RBM in children.

Methods: This article retrospectively reviews the clinical characteristics, etiologies, and treatments in children with RBM hospitalized in Hebei children's hospital from 2012 to 2020. Read More

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Clinical characteristics and outcomes after new-onset seizure among Zambian children with HIV during the antiretroviral therapy era.

Epilepsia Open 2022 06 1;7(2):315-324. Epub 2022 Apr 1.

University Teaching Hospitals Children's Hospital, Lusaka, Zambia.

Objective: This study describes clinical profiles including human immunodeficiency virus (HIV) disease history and seizure etiology among children living with HIV presenting with new-onset seizure during the era of antiretroviral therapy (ART) in Zambia. 30-day mortality and cause of death are also reported.

Methods: Children living with HIV (CLWHIV) with new-onset seizures were prospectively evaluated at one large urban teaching hospital and two non-urban healthcare facilities. Read More

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Application of a three-dimensional printed model to localize a cranial cerebrospinal fluid leak: a case report.

J Int Med Res 2022 Feb;50(2):3000605221078412

Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangzhou, China.

Localization of defect sites is a major challenge for surgical repair of cerebrospinal fluid (CSF) leaks. Here, we report a case in which we applied a 3-dimensional (3D) printed model to accurately identify the defect sites and facilitate the successful repair of a cranial CSF leak. A 37-year-old female patient diagnosed with recurrent nasopharyngeal carcinoma suffered CSF rhinorrhea and severe bacterial meningitis. Read More

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February 2022

Mild encephalitis/encephalopathy with a reversible splenial lesion associated with systemic Mycoplasma pneumoniae infection in North America: a case report.

J Med Case Rep 2022 Feb 20;16(1):74. Epub 2022 Feb 20.

Department of Neurology, Memorial Hermann Hospital, University of Texas Health Science Center at Houston, 6410 Fannin St, Ste 1014, Houston, TX, 77030, USA.

Background: Mild encephalitis/encephalopathy with reversible splenial lesion is a clinical-radiological entity found to occur in the setting of an acute systemic inflammatory state with isolated lesions of the splenium of the corpus callosum and mild encephalopathy. Mild encephalitis/encephalopathy with reversible splenial lesion is commonly found to occur in children in the setting of viral infections. It has rarely been associated with Mycoplasma pneumoniae in the United States, unlike in Eastern and Southern Asia where this is much more prominent. Read More

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February 2022

Comparison of Four International Guidelines on the Utility of Cranial Imaging Before Lumbar Puncture in Adults with Bacterial Meningitis.

Clin Neuroradiol 2022 Feb 18. Epub 2022 Feb 18.

Department of Medicine, Section of Infectious Disease, McGovern Medical School, UTHealth Science Center, 6410 Fannin St., 77030, Houston, TX, USA.

Background: International guidelines exist for obtaining a head computed tomography (CT) scan before a lumbar puncture (LP) in adults with suspected meningitis but there are no studies comparing them in their ability to identify intracranial abnormalities.

Methods: A retrospective study of 202 cases of adults with community-acquired bacterial meningitis at 16 hospitals in Houston from December 2004 until May 2019 to compare the 4 guidelines' ability in identifying minor and major intracranial findings, cases in which CT findings changed management, and patients who suffered cerebral herniation.

Results: Minor and major intracranial findings were seen in 69 (34. Read More

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February 2022

Hydrocephalus in Tuberculous Meningitis - Pearls and Nuances.

Neurol India 2021 Nov-Dec;69(Supplement):S330-S335

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Tuberculous meningitis (TBM) is associated with high mortality. A large proportion of patients with TBM, who survive, live with disabling neurological sequelae. Hydrocephalus is one of the common complications of TBM, seen in up to 80% of patients. Read More

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February 2022

Baclofen Withdrawal With Reversible Posterior Leukoencephalopathy Syndrome: Bacterial Meningitis Mimicker.

J Emerg Med 2022 May 31;62(5):e98-e100. Epub 2022 Jan 31.

Advanced Emergency and Critical Care Center, Akita University Hospital, Akita City, Japan.

Background: The intrathecal baclofen (ITB) pump is an effective treatment for patients with spasticity unresponsive to oral medication.

Case Report: A 31-year-old woman with spinal cord injury sequelae was admitted to the emergency department due to sudden headache and excessive confusion. The patient was on ITB for lower limb spasticity. Read More

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High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis.

J Clin Invest 2022 03;132(6)

Center for Infection and Inflammation Imaging Research.

Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the bactericidal activity of the standard-dose (10 mg/kg/d) rifampin-containing TB regimen in pulmonary TB. However, there are conflicting clinical data regarding its benefit for TB meningitis, where outcomes may also be associated with intracerebral inflammation. Read More

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Rapid progressive destruction of the cochleae in an infant due to pneumococcal meningitis.

J Infect Chemother 2022 Jun 22;28(6):806-809. Epub 2022 Jan 22.

Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.

The widespread adoption of pneumococcal conjugate vaccines has reduced the incidence of Streptococcus pneumoniae infections, but has also led to the emergence of infections due to non-vaccine serotypes. A 15-month-old girl was referred to our hospital with suspected meningitis. S. Read More

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Children suspected of having intracranial infection with normal brain magnetic resonance imaging may be associated with the myelin oligodendrocyte glycoprotein antibody.

Brain Dev 2022 Apr 15;44(4):281-286. Epub 2022 Jan 15.

Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Purpose: To confirm whether encephalitis due to unknown causes but with normal brain magnetic resonance imaging (MRI) may be associated with the myelin oligodendrocyte glycoprotein (MOG) antibody.

Methods: We retrospectively analyzed and summarized the characteristics of three patients initially suspected of having intracranial infections with normal brain MRI, and ultimately tested positive for anti-MOG antibody.

Results: The three patients mainly presented with long-term fever accompanied by headaches and drowsiness. Read More

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NMR based CSF metabolomics in tuberculous meningitis: correlation with clinical and MRI findings.

Metab Brain Dis 2022 03 14;37(3):773-785. Epub 2022 Jan 14.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.

We report the potential role of H Nuclear Magnetic Resonance (NMR) based metabolomics in tuberculous meningitis (TBM). We also correlate the significant metabolites with clinical-radiological parameters. Forty-three patients with TBM were included, and their severity of meningitis was graded as stages I to III, and patients with positive Mycobacterium tuberculosis or its nucleic acid was considered as definite TBM. Read More

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Klebsiella pneumoniae-related brain abscess and meningitis in adults: Case report.

Medicine (Baltimore) 2022 Jan;101(2):e28415

Department of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, 12th Jiankang Road, Shijiazhuang, P.R. China.

Introduction: Klebsiella pneumoniae is once thought to be a less common cause of brain abscess in adults and is mainly hospital-acquired. Community-acquired CNS infection (brain abscess and meningitis) caused by K pneumoniae without other metastatic septic abscesses is exceedingly rare. Therefore, we present a rare adult patient with invasive cerebral abscess and meningitis without other invasive abscesses related to K pneumoniae. Read More

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January 2022

Multiple Endocrine Neoplasia Type 1 (MEN1) Presenting as an Invasive Macroprolactinoma Complicated by Acute Bacterial Meningitis.

Cureus 2021 Dec 1;13(12):e20086. Epub 2021 Dec 1.

Endocrinology, Southern Illinois University School of Medicine, Springfield, USA.

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder characterized by tumors of parathyroid, anterior pituitary, and pancreatic islet cells. Pituitary adenomas in MEN1 can be aggressive and invade surrounding structures including the skull base. However, acute bacterial meningitis in patients with newly diagnosed macroprolactinomas is an exceptional finding. Read More

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December 2021

Large Cerebral Infarction in Tuberculous Meningitis: Case Report of an Uncommon Complication.

Neurol India 2021 Nov-Dec;69(6):1859-1860

Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

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January 2022

Polymicrobial anaerobic bacterial meningitis secondary to dermal sinus: a case report.

Transl Pediatr 2021 Nov;10(11):3118-3123

Department of Infectious Diseases, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Anaerobic bacterial meningitis is a rare infectious disease, and there are some special predisposing factors for it. We report a case of polymicrobial anaerobic bacterial meningitis in a nine-month-old boy who visited our hospital due to "fever with drowsiness and vomiting for 2 days". It was confirmed by the method of sanger sequencing after polymerase chain reaction (PCR) that the purulent meningitis was caused by a mixture of four anaerobic bacteria (Finegoldia magna, Campylobacter ureolyticus, Bacteroides fragilis and Porphyromonas bennonis). Read More

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November 2021

Tuberculostearic acid, a potential parameter for scoring system construction for tuberculous meningitis diagnosis.

Int J Mycobacteriol 2021 Oct-Dec;10(4):428-432

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: This study aimed to validate the value of tuberculostearic acid (TBSA) whether it could implicate the existence of Mycobacterium tuberculosis (Mtb) and assist for the clinical diagnosis of tuberculous meningitis (TBM).

Methods: The patient's cerebrospinal fluid (CSF) specimen was collected through the lumbar puncture and detected for TBSA with gas chromatography/mass spectrometry. At the same time, gold standard tests, i. Read More

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January 2022