2,690 results match your criteria Imaging in Bacterial Meningitis


Neonatal bacterial meningitis versus ventriculitis: a cohort-based overview of clinical characteristics, microbiology and imaging.

Eur J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Department of Neonatal Intensive Care, Amsterdam University Medical Centre, Amsterdam, Netherlands.

Central nervous system (CNS) infections are potentially life threatening in neonates and can lead to the ill-defined diagnosis of ventriculitis. With this study we aimed to explore and describe ventriculitis regarding clinical, microbiological and ultrasonographic characteristics. We performed a retrospective cohort study including all neonates with a culture-proven CNS infection admitted to our tertiary NICU over a 12-year period (2004-2016). Read More

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http://dx.doi.org/10.1007/s00431-020-03723-3DOI Listing

Staphylococcal meningitis therapy with linezolid in a young infant: efficacy, CSF levels and side effects.

Ital J Pediatr 2020 Jun 29;46(1):90. Epub 2020 Jun 29.

Department of Pediatric Medicine, Laboratory of Metabolic Biochemistry Unit, Bambino Gesù Children's Hospital, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Linezolid is a synthetic antibiotic which is active against most Gram-positive bacteria, especially on Staphylococcus aureus. Its administration can be required when the infection is due to staphylococcus strains, which are resistant to vancomycin. Although mostly well tolerated, some mild to moderate side effects have been reported. Read More

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http://dx.doi.org/10.1186/s13052-020-00854-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325046PMC

Otopathologic Analysis of Patterns of Postmeningitis Labyrinthitis Ossificans.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820934748. Epub 2020 Jun 30.

Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.

Objective: Labyrinthitis ossificans (LO) may occur following meningitis and, in cases where cochlear implantation is indicated, complicate electrode insertion. LO is critical to identify for successful cochlear implantation, and histopathology is more sensitive than imaging for identification of LO. Herein we utilize otopathologic techniques to study the timing and location of intracochlear tissue formation following meningitic labyrinthitis (ML). Read More

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http://dx.doi.org/10.1177/0194599820934748DOI Listing

Ruptured Vertebral Artery Dissecting Aneurysm in a Patient with Recurrent Bacterial Meningitis.

World Neurosurg 2020 Jun 22. Epub 2020 Jun 22.

Department of Neurosurgery, University of Louisville, Louisville, KY.

Background: Intracranial mycotic aneurysms are uncommon, it can occur due extravascular extension or intravascular seeding of the vessel wall. It often results subarachnoid hemorrhage (SAH) with poor prognosis. We present a rare case of ruptured proximal anterior inferior cerebellar artery- posterior inferior cerebellar artery (AICA-PICA) mycotic aneurysm after an episode of bacterial meningitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.090DOI Listing

Posterior reversible encephalopathy syndrome as a complication of bacterial meningitis.

Hippokratia 2019 Jul-Sep;23(3):131-134

Second Internal Medicine Department, Volos General Hospital, Volos, Greece.

Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome, which is presented with headache, seizures, altered mental consciousness, and visual disturbances, and is characterized by white matter vasogenic edema, predominantly affecting the posterior occipital and parietal lobes of the brain. This clinical syndrome is increasingly recognized due to the improvement and availability of brain imaging and, more specifically, magnetic resonance imaging.

Case Report: We report the case of an otherwise healthy 20-year-old female who presented with fever, headache, and generalized arthralgia, raising the suspicion of serotype B meningitis, which was later complicated by PRES. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307506PMC

An autopsy case of tuberculous meningitis undiagnosed by nested-PCR of CSF samples and brain biopsy.

J Neurol Sci 2020 Jun 3;415:116968. Epub 2020 Jun 3.

Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Aging and Dementia (DAD), Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Nested polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) has higher diagnostic sensitivity with regard to tuberculous meningitis (TBM) than conventional methods. Herein we describe the autopsy case of a 70-year-old woman with TBM that could not be diagnosed via nested PCR in CSF, even though it was performed three times. The clinical course, magnetic resonance imaging results, and elevated adenosine deaminase levels in CSF were consistent with TBM. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116968DOI Listing

HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.

Acta Neuropathol 2020 Jun 11. Epub 2020 Jun 11.

Institute for Medical Microbiology and Infection Control, Goethe University, Frankfurt am Main, Germany.

Bacterial meningitis is a deadly disease most commonly caused by Streptococcus pneumoniae, leading to severe neurological sequelae including cerebral edema, seizures, stroke, and mortality when untreated. Meningitis is initiated by the transfer of S. pneumoniae from blood to the brain across the blood-cerebrospinal fluid barrier or the blood-brain barrier (BBB). Read More

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http://dx.doi.org/10.1007/s00401-020-02174-2DOI Listing

Magnetic Resonance Imaging Cerebrospinal Fluid Hydrodynamics in Patients with Meningitis.

J Clin Imaging Sci 2020 19;10:29. Epub 2020 May 19.

Departments of Neurology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India.

Objective: The objective of the study was to evaluate the cerebrospinal fluid (CSF) flow alterations in meningitis using phase-contrast magnetic resonance imaging (PCMRI).

Materials And Methods: Fifty patients with clinically confirmed or strongly suspected infectious meningitis and 20 controls were evaluated with MRI. Quantitative CSF analysis was performed at the level of cerebral aqueduct using cardiac-gated PCMRI. Read More

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http://dx.doi.org/10.25259/JCIS_24_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265375PMC

Vertebral tuberculosis as a paradoxical reaction to the treatment of pulmonary and meningeal tuberculosis in an immunocompetent patient: A case report.

Medicine (Baltimore) 2020 May;99(21):e20012

School of Medicine at Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Introduction: Paradoxical reaction in tuberculosis (TB) is defined as the reappearance of general symptoms, aggravation of pre-existing diseases, or appearance of new lesions despite adequate anti-TB therapy. It may result from the hyperactivity of the immune response, resulting in an intense inflammation. There are few cases of vertebral TB reported as paradoxical reaction, mainly among immunocompetents patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000020012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249907PMC

An unusual presentation of hemiparesis: Rapidly progressing meningitis secondary to acute mastoiditis.

IDCases 2020 18;21:e00831. Epub 2020 May 18.

North Florida Regional Medical Center, Gainesville, FL, 32605, United States.

A sixty-three year-old male who arrived to our emergency department with signs and symptoms of an acute left middle cerebral artery cerebrovascular accident. Initial neurovascular imaging failed to demonstrate any abnormalities that explained his symptoms. His neurologic status rapidly deteriorated in conjunction with the development of severe sepsis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251761PMC

Accuracy of MR Imaging for Detection of Sensorineural Hearing Loss in Infants with Bacterial Meningitis.

AJNR Am J Neuroradiol 2020 Jun 21;41(6):1081-1086. Epub 2020 May 21.

From the Edward B. Singleton Department of Radiology (G.O., M.K.K., N.D., T.A.G.M.H., S.F.K.).

Background And Purpose: Bacterial meningitis most commonly affects young children and can result in critical adverse outcomes, including sensorineural hearing loss (SNHL). The purpose of this study is to determine the diagnostic accuracy of MR imaging for predicting the development of SNHL among infants with bacterial meningitis.

Materials And Methods: A retrospective review was performed among infants (age <365 days) with bacterial meningitis ( = 115). Read More

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http://dx.doi.org/10.3174/ajnr.A6539DOI Listing

Intranasal nerve growth factor administration improves neurological outcome after GBS meningitis.

Childs Nerv Syst 2020 Apr 10. Epub 2020 Apr 10.

Institute of Pediatrics, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, RM, Italy.

Nerve growth factor (NGF) is a neurotrophin that promotes neural recovery and plasticity after experimental brain injury, supporting neuronal growth, differentiation, and survival of brain cells. Only a few studies reported NGF administration in pediatric patients with impaired brain functions after traumatic injuries, ischemic or infectious diseases, such as meningitis. We described the beneficial therapeutic effects of human-recombinant nerve growth factor (hr-NGF) treatment in an infant with persistent unresponsive wakefulness syndrome (UWS), due to late-onset group B Streptococcus meningitis. Read More

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http://dx.doi.org/10.1007/s00381-020-04590-xDOI Listing

Acute ischaemic stroke in meningoencephalitis.

BJR Case Rep 2020 Mar 12;6(1):20190068. Epub 2020 Feb 12.

East Kest Hospitals University NHS Trust, Margate, United Kingdom.

is the third most frequent cause of bacterial meningitis and has a predilection for elderly patients and the immunosuppressed. A small number of patients with meningoencephalitis have previously been reported to experience stroke-like symptoms that were attributed to microabscess formation and the mass effect of collections of infection in the brain. These infections led to temporary neurological deficits that resolved with antimicrobial treatment, rather than to true strokes with permanent neurological deficits. Read More

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http://dx.doi.org/10.1259/bjrcr.20190068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068084PMC

Hyperinfection Associated with Bacteremia, Meningitis, Ventriculitis and Gas-Forming Spondylodiscitis: A Case Report.

Trop Med Infect Dis 2020 Mar 12;5(1). Epub 2020 Mar 12.

Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433, Singapore.

An elderly Singaporean male with no travel history was hospitalized for fever and altered mental status. Blood cultures grew , and given a preceding history of steroid use and peripheral eosinophilia, hyperinfection was suspected. Stool specimens were positive for larvae over four days, and larvae were also isolated in an early morning nasogastric aspirate specimen prior to initiation of ivermectin. Read More

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http://dx.doi.org/10.3390/tropicalmed5010044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157694PMC

When a Stroke is not Just a Stroke: Meningitis with Ventriculitis and Vasculitis: A Case Report.

J Crit Care Med (Targu Mures) 2020 Jan 31;6(1):65-70. Epub 2020 Jan 31.

Microbiology Department, Colchester General Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester United Kingdom.

Introduction: Community-acquired ventriculitis is considered a rare condition. Central nervous system (CNS) infection due to gram-negative bacilli is usually associated with previous neurosurgical interventions. The recent publication of cases of meningitis and ventriculitis suggests its prevalence may be underestimated by the literature. Read More

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http://dx.doi.org/10.2478/jccm-2020-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029403PMC
January 2020

CT-guided drainage of a brainstem abscess in a cat as an emergency treatment procedure.

JFMS Open Rep 2020 Jan-Jun;6(1):2055116919896111. Epub 2020 Feb 10.

Small Animal Teaching Hospital, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.

Case Summary: A 3-year-old male neutered domestic shorthair cat was presented with a 1-week progressive and rapidly deteriorating history of lethargy and abnormal behaviour. Neurolocalisation indicated multifocal intracranial lesions (right oculomotor nerve, brainstem [obtundation, non-ambulatory tetraparesis, vestibular dysfunction and intermittent decerebrate rigidity] and possibly the thalamus [left-sided pleurothotonus]), or more likely a single brainstem lesion with mass effect. MRI of the brain demonstrated a brainstem abscess causing severe dorsal displacement particularly affecting the pons and the medulla oblongata causing cerebellar vermis herniation through the foramen magnum. Read More

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http://dx.doi.org/10.1177/2055116919896111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011327PMC
February 2020

Ductal Adenocarcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland: a Rare and Morbid Malignancy.

Case Rep Oncol Med 2020 3;2020:1790106. Epub 2020 Feb 3.

Department of Hematology-Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is a rare malignant transformation of a benign primary pleomorphic adenoma (PA). We report the case of a 62-year-old male who presented with a swelling over his left temple. Imaging revealed a lytic lesion over the left orbital wall with soft tissue extension suggestive of malignancy. Read More

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http://dx.doi.org/10.1155/2020/1790106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021468PMC
February 2020

State-of-the-art in the pneumococcal field: Proceedings of the 11 International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11).

Pneumonia (Nathan) 2020 5;12. Epub 2020 Feb 5.

2Murdoch Children's Research Institute, Parkville, VIC Australia.

The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) is the premier global scientific symposium dedicated to the exchange, advancement and dissemination of the latest research on the pneumococcus, one of the world's deadliest bacterial pathogens. Since the first ISPPD was held in 1998, substantial progress has been made to control pneumococcal disease, for instance, more than half of surviving infants (78.6 million) from 143 countries now have access to the life-saving pneumococcal conjugate vaccine (PCV). Read More

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http://dx.doi.org/10.1186/s41479-019-0064-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001343PMC
February 2020

Spontaneous extensive pneumocephalous as a rare manifestation of suppurative meningitis in Diabetic ketoacidosis.

BMJ Case Rep 2020 01 29;13(1). Epub 2020 Jan 29.

Department of General Medicine, Government Medical College and Hospital, Chandigarh, India

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http://dx.doi.org/10.1136/bcr-2020-234281DOI Listing
January 2020

Nocardia farcinica as a cause of chronic meningitis - case report.

BMC Infect Dis 2020 Jan 17;20(1):56. Epub 2020 Jan 17.

Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Zurawia 14; 15-540, Bialystok, Poland.

Background: Nocardiosis is an uncommon disease caused by aerobic gram-positive bacteria Nocardia spp. Although it is usually an opportunistic infection affecting immunocompromised patients, even one third of cases occur in immunocompetent persons. The aim of the study was to describe the course of chronic meningitis due to Nocardia infection. Read More

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http://dx.doi.org/10.1186/s12879-020-4764-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969415PMC
January 2020

Microbiological diagnosis of tuberculous meningitis: Phenotype to genotype.

Indian J Med Res 2019 11;150(5):448-457

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Tuberculous meningitis (TBM) is a commonly encountered central nervous system infection. Characteristic clinical, imaging and cerebrospinal fluid parameters help clinicians to make a prompt presumptive diagnosis that enables them to start empirical anti-tuberculosis treatment. There are several close mimic to TBM, such as partially treated pyogenic meningitis, fungal meningitis, sarcoidosis, meningeal metastases and meningeal lymphomatosis. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1145_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977359PMC
November 2019

Propionibacterium acnes-associated chronic hypertrophic pachymeningitis followed by refractory otitis media: a case report.

BMC Neurol 2020 Jan 9;20(1):11. Epub 2020 Jan 9.

Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo, 113-8519, Japan.

Background: Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial and fungal infections, cancer, and idiopathic diseases, when evaluation fails to reveal a cause. Among them, chronic infection with Propionibacterium acnes is a rare etiology of HP, and its pathology remains unclear. Read More

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http://dx.doi.org/10.1186/s12883-020-1600-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953232PMC
January 2020

Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study.

J Neuroinflammation 2020 Jan 4;17(1). Epub 2020 Jan 4.

Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Background: Bacterial meningitis is a devastating central nervous system (CNS) infection with acute and long-term neurological consequences, including cognitive impairment. The aim of this study was to understand the association between activated microglia-induced neuroinflammation and post-meningitis cognitive impairment.

Method: Meningitis was induced in male Wistar rats by injecting Streptococcus pneumoniae into the brain through the cisterna magna, and rats were then treated with ceftriaxone. Read More

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http://dx.doi.org/10.1186/s12974-019-1692-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942362PMC
January 2020

[Autoimmune chronic meningitis secondary to pneumococcal meningitis. Report of one case].

Rev Med Chil 2019 Jun;147(6):803-807

Servicio de Neurología, Hospital del Salvador, Santiago, Chile.

Pneumococcal meningitis produces several inflammatory disorders in susceptible subjects. A worsening of meningitis can occur on the fourth day of evolution in relation with the withdrawal of steroids. Other complications include the development of inflammatory signs in the post-acute stage of infection associated with disseminated vasculitis of the cerebral blood vessels and, even later, an autoimmune chronic meningitis. Read More

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http://dx.doi.org/10.4067/S0034-98872019000600803DOI Listing

Spontaneous Tension Pneumocephalus.

Acta Med Port 2019 Dec 2;32(12):788. Epub 2019 Dec 2.

Serviço de Medicina IV. Hospital Prof. Doutor Fernando Fonseca. Amadora. Portugal.

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http://dx.doi.org/10.20344/amp.11591DOI Listing
December 2019

Developing a newborn rat model of ventriculitis without concomitant bacteremia by intraventricular injection of K1 (-) Escherichia coli.

Pediatr Int 2020 Mar;62(3):347-356

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Neonatal meningitis caused by Escherichia coli results in high mortality and neurological disabilities, and the concomitant systemic bacteremia confounds its mortality and brain injury. This study developed an experimental model of neonatal ventriculitis without concomitant systemic bacteremia by determining the bacterial inoculum of K1 capsule-negative E. coli by intraventricular injection in newborn rats. Read More

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http://dx.doi.org/10.1111/ped.14108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187168PMC

Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis.

BMC Neurol 2019 Dec 12;19(1):320. Epub 2019 Dec 12.

Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9# Jin Sui Road, 510623, Guangzhou City, Guangdong Province, People's Republic of China.

Background: X-linked agammaglobulinaemia (XLA) is a rare inherited primary immunodeficiency disease characterized by the B cell developmental defect, caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK), which may cause serious recurrent infections. The diagnosis of XLA is sometimes challenging because a few number of patients have higher levels of serum immunoglobulins than expected. In this study, we reported an atypical case with recurrent meningitis, delayed diagnosis with XLA by genetic analysis at the second episode of meningitis at the age of 8 years. Read More

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http://dx.doi.org/10.1186/s12883-019-1536-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907138PMC
December 2019

Meningitis and Pyogenic Spondylodiscitis in a Healthy Young Woman.

Case Rep Neurol 2019 Sep-Dec;11(3):299-303. Epub 2019 Nov 20.

Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.

We report a rare case of meningitis and pyogenic spondylodiscitis in a healthy young woman. A 35-year-old woman without significant medical history presented with fever, headache, and low back pain. was detected from the blood culture. Read More

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http://dx.doi.org/10.1159/000503814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902222PMC
November 2019

[Cerebral venous thrombosis: Clinical and radiological features, about 62 cases].

J Med Vasc 2019 Dec 1;44(6):387-399. Epub 2019 Oct 1.

Service de radiologie, faculté de médecine et de pharmacie, université Sidi Mohammed Ben Abdellah, CHU Hassan II Fès, Fès, Maroc.

The work's purpose is to make a general review on the various clinical-radiological aspects and the management of cerebral venous thrombosis (CVT) in our hospital and compare them to those described in the literature.

Material And Method: Our series included 62 patients aged over 18 years, collected over 7 years (2009-2016) in the radiology department of the CHU Hassan II of Fez (Morocco), in which the radiological diagnosis of TVC was retained. Our patients have benefited from a brain CT scan and brain MRI. Read More

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http://dx.doi.org/10.1016/j.jdmv.2019.09.011DOI Listing
December 2019

Streptococcus Oralis meningitis from right sphenoid Meningoencephalocele and cerebrospinal fluid leak.

BMC Infect Dis 2019 Nov 11;19(1):960. Epub 2019 Nov 11.

Department of Internal Medicine, Zucker School of Medicine at Hofstra Northwell, Lenox Hill Hospital New York, New York, USA.

Background: Streptococcus oralis belongs to the Streptococcus mitis group and is part of the normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II: streptococci, enterococci and the 'Streptococcus-like' bacteria. Color atlas and textbook of diagnostic microbiology, 1997). Read More

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http://dx.doi.org/10.1186/s12879-019-4472-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849159PMC
November 2019

Rare Meningitis and Epileptic Seizure Infected with Brucella melitensis: a Case Report.

Clin Lab 2019 Nov;65(11)

Background: Although brucellosis is the most common zoonotic disease worldwide, human meningitis infected with Brucella melitensis is rare and difficult to diagnosis. Herein we describe the clinical aspects of a rare case of Brucella melitensis meningitis accompanied by epileptic seizure.

Methods: Bacterial culture of CSF was utilized to find the pathogen. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.180624DOI Listing
November 2019

Contrast-enhanced modified 3D T1-weighted TSE black-blood imaging can improve detection of infectious and neoplastic meningitis.

Eur Radiol 2020 Feb 5;30(2):866-876. Epub 2019 Nov 5.

Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Objectives: To evaluate the diagnostic value of a contrast-enhanced 3D T1-weighted-modified volumetric isotropic turbo spin-echo acquisition sequence (T1-mVISTA) in comparison with a conventional 3D T1-weighted magnetization-prepared rapid gradient-echo (T1-MP-RAGE) sequence for the detection of meningeal enhancement in patients with meningitis.

Methods: Thirty patients (infectious meningitis, n = 12; neoplastic meningitis, n = 18) and 45 matched controls were enrolled in this retrospective case-control study. Sets of randomly selected T1-mVISTA and T1-MP-RAGE images (both with 0. Read More

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http://dx.doi.org/10.1007/s00330-019-06475-3DOI Listing
February 2020
4.014 Impact Factor

A nine-day-old girl with fever.

Tidsskr Nor Laegeforen 2019 11 4;139(16). Epub 2019 Nov 4.

Nowadays severe illness in neonates is fortunately rare in Norway. However, newborns present with non-specific symptoms, making diagnostics in this age group challenging, and neonatologists need to think broadly in order not to overlook serious illness. We present the case of a nine-day-old who was severely ill when she arrived at hospital. Read More

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http://dx.doi.org/10.4045/tidsskr.18.0861DOI Listing
November 2019
1 Read

A 2-Year-Old Boy With an Unusual Bacterial Meningitis and Multiple Brain Abscesses.

J Pediatric Infect Dis Soc 2019 Nov 1. Epub 2019 Nov 1.

Department of Radiology, University Hospitals KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/jpids/piz076DOI Listing
November 2019
1 Read

[A clinical analysis of bacterial meningitis in full-term and preterm infants].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Oct;21(10):1044-1048

Department of Neonatology, Northwest Women's and Children's Hospital, Xi'an 710061, China.

Objective: To study the clinical features and prognosis of bacterial meningitis in full-term and preterm infants.

Methods: A retrospective analysis was performed for the clinical data of 102 neonates with bacterial meningitis. According to the gestational age, they were divided into a preterm group (n=46) and a full-term group (n=56). Read More

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October 2019

Successful surgical management of an Escherichia coli epidural-subdural abscess secondary to sino-rhinotomy.

J Vet Emerg Crit Care (San Antonio) 2019 Nov 22;29(6):696-701. Epub 2019 Oct 22.

Small Animal Teaching Hospital, University of Liverpool, Neston, UK.

Objective: To describe a case of successful management of epidural-subdural abscess and severe meningitis with secondary brain herniation in a dog.

Case Summary: A rhino-sinusotomy was performed in a 3-year-old mixed-breed dog for management of refractory sinonasal aspergillosis. Initial recovery was good, but the dog became acutely stuporous 36 hours after surgery. Read More

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http://dx.doi.org/10.1111/vec.12904DOI Listing
November 2019
1 Read

Medullary involvement in neurosyphilis: a report of 12 cases and a review of the literature.

Spinal Cord Ser Cases 2019 1;5:38. Epub 2019 May 1.

Neurology Department, University Hospital Mohamed VI Marrakesh, Marrakesh, Morocco.

Study Design: Retrospective case series.

Objectives: To describe the epidemiological, clinical, MRI and therapeutic features and the outcomes of patients with syphilitic myelitis in a third-level hospital in Marrakesh in southern Morocco.

Setting: The Neurology Department, University Hospital Mohamed VI Marrakesh, Morocco. Read More

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http://dx.doi.org/10.1038/s41394-019-0185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786502PMC
June 2020
1 Read

Case 271: Metronidazole-induced Encephalopathy.

Radiology 2019 11;293(2):473-479

From the Section on Neuroradiology, Department of Radiology (Y.S., H.M.), and Section on Pediatric Neurology, Department of Pediatrics (P.J.O.), New York Medical College, Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595.

HistoryAn 11-year-old boy taking oral antibiotics for meningitis diagnosed 3 months earlier presented to the emergency department with a 1-week history of intermittent emesis, dizziness, and vertigo and a 1-day history of wobbly gait and bilateral lower extremity paresthesia without confusion. His metabolic profile was normal. Contrast material-enhanced MRI of the brain was performed. Read More

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http://dx.doi.org/10.1148/radiol.2019171079DOI Listing
November 2019
1 Read

Dorsal subscapularis approach for the surgical drainage of subscapularis intramuscular abscess: a case report.

BMC Musculoskelet Disord 2019 Oct 12;20(1):445. Epub 2019 Oct 12.

Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.

Background: Abscess formation in the subscapularis muscle is a rare clinical condition. Few reports are available regarding the treatment methods and surgical approaches for subscapularis intramuscular abscesses. Here, we describe a case of subscapularis intramuscular abscess that was treated successfully via surgical drainage using a new approach, the "dorsal subscapularis approach". Read More

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http://dx.doi.org/10.1186/s12891-019-2852-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790034PMC
October 2019
1 Read

Non-Traumatic Pneumocephalus and Sub-Dural Empyema as a Complication of Chronic Sinusitis.

Cureus 2019 Jul 22;11(7):e5202. Epub 2019 Jul 22.

Internal Medicine, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, PAK.

Infectious sinusitis is extremely common in children, and persistent infection can lead to many complications. The most dangerous and commonly reported complications are intracranial. These intracranial complications include pneumocephalus, cerebral abscess, subdural empyema, meningitis, cellulitis, orbital abscess, and cavernous sinus thrombosis. Read More

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http://dx.doi.org/10.7759/cureus.5202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758996PMC
July 2019
3 Reads

[A case of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) associated with infectious endocarditis caused by Staphylococcus aureus].

Rinsho Shinkeigaku 2019 Oct 28;59(10):666-668. Epub 2019 Sep 28.

Department of Neurology, Toyama University Hospital.

A 17-year-old woman was admitted to our hospital because of a high fever, consciousness disturbance, and delirious behavior. Methicillin susceptible Staphylococcus aureus (MSSA) infection was confirmed by blood culture. Transthoracic echocardiogram showed no abnormality at first. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001335DOI Listing
October 2019
11 Reads

Intracranial subdural empyemas and epidural abscesses in children

J Neurosurg Pediatr 2019 07 22;24(1):14-21. Epub 2019 Mar 22.

1Department of Neurological Surgery, University of Kansas, Kansas City, Kansas; and.

Objective: The authors conducted a retrospective analysis of a consecutive series of children with intracranial subdural empyemas (SEs) and epidural abscesses (EAs) to highlight the important clinical difference between these two entities. They describe the delays and pitfalls in achieving accurate diagnoses and make treatment recommendations based on clinical and imaging findings.

Methods: They reviewed their experience with children who had presented with intracranial SE and/or EA in the period from January 2013 to May 2018. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18434DOI Listing
July 2019
3 Reads

The Feasibility of Metagenomic Next-Generation Sequencing to Identify Pathogens Causing Tuberculous Meningitis in Cerebrospinal Fluid.

Front Microbiol 2019 3;10:1993. Epub 2019 Sep 3.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Purpose: The application of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains poorly characterized. Here, we retrospectively analyzed data from patients with TBM who had taken both mNGS and conventional tests including culture of (MTB), polymerase chain reaction (PCR) and acid-fast bacillus (AFB) stain, and the sensitivity and specificity of these methods were compared.

Methods: We retrospectively recruited TBM patients admitted to the hospital between December 2015 and October 2018. Read More

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http://dx.doi.org/10.3389/fmicb.2019.01993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733977PMC
September 2019
2 Reads
3.941 Impact Factor

Neurological Complications of Endocarditis: A Multidisciplinary Review with Focus on Surgical Decision Making.

Semin Neurol 2019 08 18;39(4):495-506. Epub 2019 Sep 18.

Department of Neurology, Boston Medical Center, Boston, Massachusetts.

Infective endocarditis (IE) is a systemic disease with many potential neurologic manifestations including ischemic and hemorrhagic strokes, cerebral microbleeding, infectious intracranial aneurysms, meningitis, brain abscesses, and encephalopathy. The majority of left-sided (heart) IE patients have brain lesions that may alter management decisions, warranting the systematic use of magnetic resonance imaging. Many patients require surgical treatment of valvular disease, and central nervous system lesions weigh into decision making. Read More

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http://dx.doi.org/10.1055/s-0039-1688826DOI Listing
August 2019
5 Reads

Infectious Etiologies of Stroke.

Semin Neurol 2019 08 18;39(4):482-494. Epub 2019 Sep 18.

Boston University School of Medicine, Boston University, Boston, Massachusetts.

Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in addition to a detailed history and neurologic examination. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687915
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http://dx.doi.org/10.1055/s-0039-1687915DOI Listing
August 2019
4 Reads

Neurotuberculosis: A Clinical Review.

Authors:
Jerome H Chin

Semin Neurol 2019 08 18;39(4):456-461. Epub 2019 Sep 18.

Department of Neurology, NYU Langone Health, New York, New York.

In September 2018, the United Nations General Assembly held the first ever meeting to discuss the global epidemic of tuberculosis (TB) and adopted a political declaration titled "United to end tuberculosis: an urgent global response to a global epidemic." The timing of the meeting was prescient but overdue since surpassed the human immunodeficiency virus as the world's leading infectious killer in 2014. Infection of the central nervous system by , herein referred to as neurotuberculosis, is the most feared and dangerous form of tuberculosis, requiring a high level of suspicion and clinical experience for prompt diagnosis and treatment. Read More

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http://dx.doi.org/10.1055/s-0039-1687840DOI Listing

A Neurologist's View of Lyme Disease and Other Tick-Borne Infections.

Authors:
John J Halperin

Semin Neurol 2019 08 18;39(4):440-447. Epub 2019 Sep 18.

Department of Neurosciences, Overlook Medical Center, Summit, New Jersey.

Tick-borne infections-including tick-borne encephalitis viruses, represented in the United States by rare infections with Powassan and deer tick viruses, and more often Lyme disease-are of increasing importance to neurologists. Lyme neuroborreliosis (LNB) causes all or part of a triad including meningitis, radiculoneuritis, and cranial neuritis. Rarely, parenchymal brain and spinal cord involvement occur, with focal findings on examination and magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1055/s-0039-1692143DOI Listing
August 2019
4 Reads

Dermal sinus tracts.

BMJ 2019 Sep 4;366:l5202. Epub 2019 Sep 4.

Department of Neurosurgery, Alder Hey NHS Foundation Trust, Liverpool L12 2AP, UK.

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http://dx.doi.org/10.1136/bmj.l5202DOI Listing
September 2019
8 Reads

[Extra-ventricular drainage for the treatment of pneumococcal meningitis and hydrocephalus: a case report].

Rinsho Shinkeigaku 2019 Sep 30;59(9):584-588. Epub 2019 Aug 30.

Department of Neurology, Chikamori Hospital.

A 53-year-old man was referred to our hospital because of fever and disturbed consciousness with a left-sided toothache from 5 days ago. Neurological examinations revealed a low level of consciousness, nuchal rigidity, bilateral mydriasis, and positive Babinski sign. A lumbar puncture yielded clouded fluid with a WBC 22,698/μl (polynuclear cell 98%), 681 mg/dl of protein and 0 mg/dl of glucose. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001322DOI Listing
September 2019
2 Reads