3,694 results match your criteria Imaging in Asthma


Recurrent myocardial infarction in a 50-year-old woman.

Heart 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Hairmyres, East Kilbridge, UK.

CLINICAL INTRODUCTION: A 50-year-old woman presented with an inferoposterior ST-elevation myocardial infarction (STEMI) and underwent emergency percutaneous coronary intervention (PCI). Angiography revealed acute occlusion of the circumflex and right coronary (RCA) arteries. PCI was uncomplicated. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314114
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http://dx.doi.org/10.1136/heartjnl-2018-314114DOI Listing
February 2019
1 Read

Respiratory system reactance reflects communicating lung volume in chronic obstructive pulmonary disease.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Respiratory Medicine, Woolcock Institute, University of Sydney, Australia.

Respiratory system reactance (Xrs) measured by the forced oscillation technique (FOT) is theoretically and experimentally related to lung volume. In chronic obstructive pulmonary disease (COPD), the absolute volume measured by body plethysmography includes a proportion which is inaccessible to pressure oscillations applied via the mouth - that is, a 'non-communicating' lung volume. We hypothesized that, in COPD, the presence of non-communicating lung would disrupt the expected Xrs-volume relationship when compared to plethysmographic functional residual capacity (FRC). Read More

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http://dx.doi.org/10.1152/japplphysiol.00503.2018DOI Listing
February 2019

Unusual cause of an elevated hemidiaphragm: large right-sided spontaneous diaphragmatic hernia induced by severe chronic cough in an adolescent patient with asthma.

Intern Med J 2019 Feb;49(2):273-274

Department of Respiratory Medicine and Sleep Disorders, Western Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/imj.14196DOI Listing
February 2019
1 Read

Formoterol counteracts the inhibitory effect of cigarette smoke on glucocorticoid-induced leucine zipper (GILZ) transactivation in human bronchial smooth muscle cells.

Eur J Pharmacol 2019 Feb 10;850:8-14. Epub 2019 Feb 10.

Department of Pharmacology and Toxicology, Corporate Pre-Clinical R&D, Chiesi Farmaceutici S.p.A., Parma, Italy. Electronic address:

Cigarette smokers with asthma and chronic obstructive pulmonary disease (COPD) are less responsive to glucocorticoids (GCs). The anti-inflammatory action of GCs depends also on their ability to transactivate genes such as GC-induced leucine zipper (GILZ). We investigated the effects of aqueous cigarette smoke extract (CSE) on GILZ transactivation evoked by 17-beclomethasone monopropionate (BMP) or fluticasone propionate (FP) in the presence or absence of the long acting β2-adrenoceptor agonist (LABA) bronchodilator formoterol or salmeterol in human primary cultures of human bronchial smooth muscle cells (HBSMC). Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.010DOI Listing
February 2019
1 Read

Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities.

Anesth Pain Med 2018 Dec 28;8(6):e84179. Epub 2018 Nov 28.

Department of Internal Medicine, Division of Rheumatology, Jeju National University Hospital, Jeju, Korea.

Introduction: Churg-Strauss syndrome (CSS; or eosinophilic granulomatosis with polyangiitis) is an extremely rare autoimmune condition characterized by hypereosinophilia and vasculitis of small or medium-sized blood vessels, occurring in patients with asthma and allergic rhinitis.

Case Presentation: A 47-year-old man (height, 175.8 cm and weight, 74. Read More

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http://dx.doi.org/10.5812/aapm.84179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347737PMC
December 2018
1 Read

Periadrenal inflammatory myofibroblastic tumour: half a decade before cure.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Anatomic Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.

A 30-year-old ex-smoker with a background history of childhood asthma presented with worsening shortness of breath despite receiving high doses of oral corticosteroid for pemphigus vulgaris which was diagnosed 5 years earlier. A high-resolution CT examination of the thorax reported non-specific bronchiectatic changes and revealed an incidental suprarenal mass. A subsequent CT scan confirmed a large adrenal mass with areas of necrosis and calcification. Read More

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http://dx.doi.org/10.1136/bcr-2018-225687DOI Listing
February 2019

Redox imaging and optical coherence tomography of the respiratory ciliated epithelium.

J Biomed Opt 2019 Jan;24(1):1-4

University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, Wisconsin, United States.

Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary information to OCT for airway and lung imaging. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.010501DOI Listing
January 2019
2 Reads

BMI but not central obesity predisposes to airway closure during bronchoconstriction.

Respirology 2019 Jan 29. Epub 2019 Jan 29.

Division of Pulmonary and Critical Care Medicine, Vermont Lung Center, University of Vermont Larner College of Medicine, Burlington, VT, USA.

Background And Objective: Obesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. Read More

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http://dx.doi.org/10.1111/resp.13478DOI Listing
January 2019
1 Read

Functional Ct Imaging For Identification Of The Spatial Determinants Of Small Airways Disease In Adult Asthma.

J Allergy Clin Immunol 2019 Jan 22. Epub 2019 Jan 22.

NIHR Respiratory Biomedical Research Centre (BRC), Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK. Electronic address:

Background: Asthma is a disease characterised by ventilation heterogeneity (VH). A number of studies have demonstrated that VH markers derived using impulse oscillometry (IOS) or multiple breath washout (MBW) are associated with key asthma patient related outcome measures and airways hyper responsiveness. However the topographical mechanisms of VH in the lung remain poorly understood. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.014DOI Listing
January 2019
1 Read

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment.

J Appl Physiol (1985) 2019 Jan 24. Epub 2019 Jan 24.

School of Anatomy, Physiology and Human Biology, University of Western Australia, Australia.

Bronchial thermoplasty is a recent treatment for asthma in which ablative thermal energy is delivered to specific large airways according to clinical guidelines. Current practice is therefore effectively 'blind' as it is not informed by patient-specific data. The present study seeks to establish whether a patient-specific approach based on structural or functional patient data can improve outcomes and/or reduce the number of procedures required for clinical efficacy. Read More

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http://dx.doi.org/10.1152/japplphysiol.00951.2018DOI Listing
January 2019
2 Reads

Comparison of CT ventilation imaging and hyperpolarised gas MRI: effects of breathing manoeuvre.

Phys Med Biol 2019 Jan 23. Epub 2019 Jan 23.

Polaris, Academic Unit of Radiology, University of Sheffield, Sheffield, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung 'ventilation'. Prior to clinical use, it is important to understand how this technique compares with direct ventilation imaging modalities such as hyperpolarised gas MRI. However, variations in lung inflation level have been shown to affect regional ventilation distributions. Read More

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http://dx.doi.org/10.1088/1361-6560/ab0145DOI Listing
January 2019
1 Read

A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma.

Allergy Asthma Immunol Res 2019 Mar;11(2):254-266

Clinical Vaccine R&D Center and Department of Microbiology, Chonnam National University Medical School, Gwangju, Korea.

Purpose: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated that flagellin B (FlaB) plus allergen as a co-treatment mixture improved lung function and inhibited eosinophilic airway inflammation through the Toll-like receptor 5 signaling pathway in an ovalbumin (OVA)- or HDM-induced mouse asthma model. In the present study, we fused the major mite allergen Derp2 to FlaB and compared the therapeutic effects of the Derp2-FlaB fusion protein with those of a mixture of Derp2 and FlaB in a Derp2-induced mouse asthma model. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2019.1
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http://dx.doi.org/10.4168/aair.2019.11.2.254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340794PMC
March 2019
5 Reads

Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.

Clin Exp Rheumatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions.

Methods: The levels of 54 cytokines and chemokines were measured in the sera of 40 patients with active EGPA, 10 of these patients during inactive disease, 6 patients with HES, 8 with asthma, and 10 healthy controls. Read More

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January 2019
3 Reads

Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD.

Physiol Rep 2019 Jan;7(1):e13955

CIUSSS de l'Ouest-de-l'Île-de-Montréal, Montreal Chest Institute, Meakins-Christie Laboratories, Oscillometry Unit and Centre for Innovative Medicine, McGill University Health Centre and Research Institute, Montreal, Quebec, Canada.

Developed over six decades ago, pulmonary oscillometry has re-emerged as a noninvasive and effort-independent method for evaluating respiratory-system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized He ventilation-defect-percent (VDP) and respiratory-system resistance, reactance and reactance area (A ) measurements in 175 participants including 42 never-smokers without respiratory disease, 56 ex-smokers with chronic-obstructive-pulmonary-disease (COPD), 28 ex-smokers without COPD and 49 asthmatic never-smokers. COPD participants were dichotomized based on x-ray computed-tomography (CT) evidence of emphysema (relative-area CT-density-histogram ≤ 950HU (RA ) ≥ 6. Read More

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http://dx.doi.org/10.14814/phy2.13955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328923PMC
January 2019
1 Read

Right Diaphragmatic Eventration with an Intrathoracic Kidney: Case Report and Review of the Literature.

Case Rep Surg 2018 6;2018:2631391. Epub 2018 Dec 6.

Department of General Surgery, Jorge Reategui Delgado Hospital, Av. Grau block 11 s/n, Piura, Peru.

We aimed to review the publications on the diagnosis of diaphragmatic eventration and report on the clinical presentation and surgical treatment of a female patient aged 17 years. The present case, though quite infrequent, shows the presence of an ectopic thoracic kidney on the right side. The clinical features included dry cough, chest pain, respiratory distress, and bronchial spasms for 4 years; additionally, the patient had episodes of bronchial asthma since her childhood. Read More

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http://dx.doi.org/10.1155/2018/2631391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304889PMC
December 2018
1 Read

Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review.

Am J Trop Med Hyg 2019 Jan 7. Epub 2019 Jan 7.

Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado.

A 23-year-old recent emigrant from Afghanistan presented in August 2017 with severe wheezing and dyspnea that required hospital admission. Her illness was associated with marked peripheral blood eosinophilia (9,900-15,600/µL; 45.2-68%), as well as mild nausea, epigastric pain, and decreased appetite. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0625DOI Listing
January 2019
2 Reads

[Bilateral multifocal pigment epithelial detachments associated with inhaled corticosteroids].

Ophthalmologe 2019 Jan 9. Epub 2019 Jan 9.

Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

A 37-year-old male patient presented with metamorphopsia and unilateral visual impairment with the presence of hundreds of bilateral avascular retinal pigment epithelial detachments (PEDs). The patient suffered from allergic bronchial asthma which was treated with inhaled corticosteroids. Cessation of corticosteroid treatment resulted in flattening of larger PEDs and subsequent transition to atrophic areas over time while smaller PEDs persisted and spread peripherally over an observation period of 14½ years. Read More

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http://dx.doi.org/10.1007/s00347-018-0848-0DOI Listing
January 2019
3 Reads

Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca permeant ion channels and Ca sensitization, relaxing airway smooth muscle contraction.

Clin Exp Pharmacol Physiol 2019 Jan 4. Epub 2019 Jan 4.

Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China.

Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measurements, the examination of lung slices, imaging, and patch-clamp techniques. AZM completely inhibited acetylcholine (ACH)-induced precontraction of ASMs in animals (mice, guinea pigs, and rabbits) and humans. Read More

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http://dx.doi.org/10.1111/1440-1681.13062DOI Listing
January 2019
1 Read

Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14017

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Chronic eosinophilic pneumonia (CEP) is rare and an idiopathic disorder. The disease has been associated with drugs, infection, or irradiation, and its relationship with asthma remains unclear.

Patient Concerns: We reported a case of a 49-year-old female patient after trastuzumab and radiation therapy for breast cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344156PMC
January 2019
7 Reads

Bronchoscopic lung cryobiopsy: An Indian association for bronchology position statement.

Lung India 2019 Jan-Feb;36(1):48-59

Department of Pulmonary Medicine, Christian Medical College, Vellore, India.

Background: Bronchoscopic lung cryobiopsy (BLC) is a novel technique for obtaining lung tissue for the diagnosis of diffuse parenchymal lung diseases. The procedure is performed using several different variations of technique, resulting in an inconsistent diagnostic yield and a variable risk of complications. There is an unmet need for standardization of the technical aspects of BLC. Read More

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http://www.lungindia.com/text.asp?2019/36/1/48/249179
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http://dx.doi.org/10.4103/lungindia.lungindia_75_18DOI Listing
January 2019
17 Reads

Risk factors for child maltreatment by the utilization of medical service and socioeconomic environment in Taiwan.

Medicine (Baltimore) 2018 Dec;97(52):e13728

Department of Pediatric Emergency Medicine.

Child maltreatment is complicated by cultural, welfare, and socioeconomic factors. However, the relationship between child maltreatment and socioeconomic factors has not been completely understood. We investigated risk factors for child abuse and neglect in Taiwan. Read More

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http://dx.doi.org/10.1097/MD.0000000000013728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314714PMC
December 2018

Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology.

J Allergy Clin Immunol 2018 Dec 19. Epub 2018 Dec 19.

Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Background: The prevalence of chronic rhinosinusitis (CRS) measured in epidemiologic studies is 5% to 12%. This might be an overestimation because of overlap with other diseases, such as allergic rhinitis.

Objective: We aimed to calculate the prevalence of CRS using a combination of epidemiologically based CRS according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) together with sinonasal opacification on imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183278
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http://dx.doi.org/10.1016/j.jaci.2018.12.986DOI Listing
December 2018
8 Reads

Lung elastic recoil and ventilation heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction.

Eur Respir J 2018 Dec 21. Epub 2018 Dec 21.

The University of Sydney, Woolcock Institute of Medical Research, Airway Physiology and Imaging Group, Sydney, Australia.

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http://dx.doi.org/10.1183/13993003.01028-2018DOI Listing
December 2018
1 Read

Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.

PLoS One 2018 19;13(12):e0208337. Epub 2018 Dec 19.

Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

Background: Asthma exacerbations cause lung hyperinflation, elevation in load to inspiratory muscles, and decreased breathing capacity that, in severe cases, may lead to inspiratory muscle fatigue and respiratory failure. Hyperinflation has been attributed to a passive mechanical origin; a respiratory system time-constant too long for full exhalation. However, because the increase in volume is also concurrent with activation of inspiratory muscles during exhalation it is unclear whether hyperinflation in broncho-constriction is a passive phenomenon or is actively controlled to avoid airway closure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300269PMC
December 2018
6 Reads

SPECT Ventilation Imaging in Asthma.

Semin Nucl Med 2019 01 20;49(1):11-15. Epub 2018 Nov 20.

Airway Imaging and Physiology Group, The Woolcock Institute of Medical Research, Glebe NSW 2037; Department of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards NSW 2065.

Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in asthma, which is a core physiological characteristic of this disease. SPECT ventilation imaging allows topographical analysis of changes in ventilation distribution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00012998183007
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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.007DOI Listing
January 2019
8 Reads

[A Case of Autopsy of Sarcomatoid Carcinoma of the Penis with Metastasis to the Right Ventricle of the Heart].

Hinyokika Kiyo 2018 Nov;64(11):455-458

The Department of Pathology, National Hospital Organization Osaka Minami Medical Center.

A 75-year-old man with a history of early gastric cancer, phimosis and bronchial asthma experienced pain and palpated a mass in the penis in March 2015. After 2 months, he noticed bleeding from the tumor and visited our hospital. Pelvic computed tomography and magnetic resonance imaging revealed a pelvic tumor, bilateral lymphadenopathy, and para-aortic lymphadenopathy. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_455DOI Listing
November 2018
11 Reads

Cofactors of Pediatric Tinnitus: A Look at the Whole Picture.

Clin Pediatr (Phila) 2019 Mar 3;58(3):320-327. Epub 2018 Dec 3.

6 Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Retrospective chart review of 248 children (1-19 years old) with tinnitus who presented to a tertiary pediatric hospital between 2006 and 2011, looking at which cofactors are predictors of pediatric tinnitus. In our review, we extracted demographics, symptoms, historical data, imaging, and laboratory results; we compared with the general population. Eighty-seven percent had normal hearing. Read More

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http://dx.doi.org/10.1177/0009922818816426DOI Listing
March 2019
3 Reads

Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis.

Biomaterials 2019 Feb 18;192:429-439. Epub 2018 Jun 18.

Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou, Zhejiang 310058, China; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Key Site of National Clinical Research Center for Respiratory Disease, Hangzhou, Zhejiang 310009, China; State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510120, China. Electronic address:

Elimination of airway inflammatory cells is essential for asthma control. As Bcl-2 protein is highly expressed on the mitochondrial outer membrane in inflammatory cells, we chose a Bcl-2 inhibitor, ABT-199, which can inhibit airway inflammation and airway hyperresponsiveness by inducing inflammatory cell apoptosis. Herein, we synthesized a pH-sensitive nanoformulated Bcl-2 inhibitor (Nf-ABT-199) that could specifically deliver ABT-199 to the mitochondria of bronchial inflammatory cells. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.06.020DOI Listing
February 2019
4 Reads

Noninvasive allergic sinus congestion and resolution assessments using microcomputed tomography imaging.

J Appl Physiol (1985) 2018 Nov 30;125(5):1563-1575. Epub 2018 Aug 30.

Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Texas Medical Branch , Galveston, Texas.

Sinus congestion resultant of allergic rhinosinusitis is associated with development and worsening of asthma and can result in difficulty breathing, headaches, and missed days of school and work. Quantification of sinus congestion is important in the understanding of allergic rhinosinusitis and the development of new drugs for its treatment. Noninvasive microcomputed tomography (micro-CT) was investigated in a guinea pig model of allergic rhinosinusitis to determine its utility to determine accurately the degree of sinus congestion and resolution with anti-inflammatory drug administration. Read More

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https://www.physiology.org/doi/10.1152/japplphysiol.00980.20
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.00980.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295483PMC
November 2018
10 Reads

Unravelling the apoptotic mechanisms in T-lymphocytes in an animal model for pollen induced airway allergy and studying the impact of specific immunotherapy.

Immunobiology 2018 Nov 16. Epub 2018 Nov 16.

Department of Laboratory Medicine, School of Tropical Medicine, 108 C. R. Avenue, Kolkata, 700073, West Bengal, India. Electronic address:

Asthma is a chronic inflammatory disorder of the airways, increasing in prevalence worldwide. Reduced T cell apoptosis may interfere with the down-regulation of an immune response resulting in T cell accumulation contributing to the chronic inflammation of asthma. Most studies focused so far on apoptosis of eosinophils but the detailed role of T lymphocytes apoptosis in allergic diseases is unclear yet. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.008DOI Listing
November 2018
6 Reads
3.044 Impact Factor

Assessment of lateral mitral, septal and tricuspid myocardial performance indices by tissue Doppler imaging in asthmatic children.

Clin Respir J 2018 Dec;12(12):2676-2682

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Introduction: Recurrent hypoxia makes asthmatics at risk for pulmonary hypertension and ventricular dysfunction. Early stages of these cardiovascular diseases cannot be detected by conventional echocardiography. Tissue Doppler imaging has been introduced recently as a more sensitive and more accurate tool for investigating cardiovascular diseases. Read More

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http://doi.wiley.com/10.1111/crj.12974
Publisher Site
http://dx.doi.org/10.1111/crj.12974DOI Listing
December 2018
9 Reads

Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16.

Cell Mol Immunol 2019 Jan 22;16(1):75-86. Epub 2018 Nov 22.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, P.R. China.

ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways. We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasal challenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attracting chemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. Read More

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http://dx.doi.org/10.1038/s41423-018-0182-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318283PMC
January 2019
2 Reads
4.112 Impact Factor

Exploring the use of single-port surgery in the conservative management of hepatic portal vein gas: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13368

Department of General and Gastroenterological Surgery.

Rationale: Hepatic portal vein gas (HPVG) is known as a sign of a lethal condition resulting from bowel necrosis. Recently, the detection rate of non-life-threatening cases of HPVG has increased due to the technological development of imaging, i.e. Read More

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http://dx.doi.org/10.1097/MD.0000000000013368DOI Listing
November 2018
10 Reads

Initiating drug therapy in early stage chronic obstructive pulmonary disease: does it impact the course and outcome?

Curr Opin Pulm Med 2019 Mar;25(2):132-137

Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose Of Review: Early chronic obstructive pulmonary disease (COPD) is emerging in importance for the clinical and research settings. This review will highlight a proposed definition of early COPD, examine early and midlife factors that lead to development of early COPD and review the literature pertaining to the treatment of mild COPD to gain insight into potential therapeutic approaches for early disease.

Recent Findings: Early COPD can be defined as disease occurring in patients younger than 50 years in age with a 10-pack-year or more smoking history and abnormal spirometry, imaging or lung function decline. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349494PMC

Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography.

Biomed Opt Express 2018 Nov 15;9(11):5437-5455. Epub 2018 Oct 15.

Optical + Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, WA 6009, Australia.

It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. Read More

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http://dx.doi.org/10.1364/BOE.9.005437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238922PMC
November 2018
2 Reads

An ounce of caution: Superparamagnetic iron oxide nanoparticle based magnetic resonance imaging contrast-associated anaphylaxis.

Ann Allergy Asthma Immunol 2019 Feb 13;122(2):210-211. Epub 2018 Nov 13.

Department of Critical Care, Mayo Clinic, Jacksonville, Florida.

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http://dx.doi.org/10.1016/j.anai.2018.11.003DOI Listing
February 2019
7 Reads
2.599 Impact Factor

Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.

Ann Am Thorac Soc 2018 Nov;15(Supplement_3):S184-S191

2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.

Autopsy studies in fatal asthma have clearly documented the central role of airway plugging with pathologic mucus in the pathophysiology of death from asthma, but the role of mucus plugs in chronic severe asthma has been less well understood. Recently, multidetector computerized tomography imaging of the lungs has emerged as a valuable method to visualize mucus plugs in asthma. These multidetector computerized tomography data have revealed mucus plugs as a common occurrence in severe forms of asthma. Read More

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https://www.atsjournals.org/doi/10.1513/AnnalsATS.201807-485
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http://dx.doi.org/10.1513/AnnalsATS.201807-485AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322032PMC
November 2018
4 Reads

Unravelling the complexity of tissue inflammation in uncontrolled and severe asthma.

Curr Opin Pulm Med 2019 Jan;25(1):79-86

Unit of Airway Inflammation, Department of Experimental Medical Research, Lund University.

Purpose Of Review: The clinical and inflammatory heterogeneity in asthma constitutes a major challenge for improved treatment. This review describes the nature of the inflammatory complexity and how it can be decoded to yield improved disease understanding and personalized treatment. The focus is on the difficult task of revealing the immunological complexity as it occurs inside diseased patient tissues. Read More

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http://Insights.ovid.com/crossref?an=00063198-900000000-9917
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http://dx.doi.org/10.1097/MCP.0000000000000536DOI Listing
January 2019
10 Reads

Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities.

Stem Cell Res Ther 2018 Nov 8;9(1):298. Epub 2018 Nov 8.

Stem Cell Facility, DBT Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, 110029, India.

Background: Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routinely used in clinical trials with no known study of their mitochondrial donor capacity. Here, we show for the first time that MSCs derived from different tissue sources have different mitochondrial donor properties and that this is correlated with their intrinsic respiratory states. Read More

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-018-1012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225697PMC
November 2018
13 Reads

Quantitative measurement of airway dimensions using ultra-high resolution computed tomography.

Respir Investig 2018 Nov 24;56(6):489-496. Epub 2018 Oct 24.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:

Background: Quantitative measurement of airway dimensions using computed tomography (CT) is performed in relatively larger airways due to the limited resolution of CT scans. Nevertheless, the small airway is an important pathological lesion in lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Ultra-high resolution scanning may resolve the smaller airway, but its accuracy and limitations are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183021
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http://dx.doi.org/10.1016/j.resinv.2018.07.008DOI Listing
November 2018
9 Reads

Primary hyperparathyroidism characterized by diffuse homogeneous metastatic pulmonary calcification: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13107

Department of Radiology, Tongde Hospital of Zhejiang Province.

Rationale: Primary hyperparathyroidism (PHPTI) with respiratory tract symptom is extremely rare. It is caused by autonomic oversecretion of parathyroid hormone (PTH) owing to parathyroid adenoma, hyperplasia, or tumor. The diagnosis of PHPTI often needs to be made based on medical history, clinical manifestation, laboratory tests, and imaging examination. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811020-0007
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http://dx.doi.org/10.1097/MD.0000000000013107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221601PMC
November 2018
8 Reads

Radiolabeling an Electronic Cigarette Aerosol Using Technetium Carbon Ultrafine Particles.

J Aerosol Med Pulm Drug Deliv 2019 Feb 30;32(1):47-53. Epub 2018 Oct 30.

1 Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Electronic cigarettes (ECIGs) are widely used, but their health effects are not well known. ECIG exposure is difficult to quantify, and a direct measurement of deposition would be beneficial to in vivo and in vitro toxicity studies. The aim of this study was to demonstrate effective radiolabeling of an ECIG. Read More

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https://www.liebertpub.com/doi/10.1089/jamp.2017.1442
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http://dx.doi.org/10.1089/jamp.2017.1442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354600PMC
February 2019
8 Reads

Emergency Tracheal Surgery for Adenoid Cystic Carcinoma: A Rare Entity.

J Coll Physicians Surg Pak 2018 Nov;28(11):882-884

Department of Thoracic Surgery, Combined Military Hospital, Lahore, Pakistan.

Primary tumours of the trachea are rare. Adenoid cystic carcinoma (ACC) constitutes less than 1% of these tumours. They occasionally masquerade as asthma. Read More

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https://www.jcpsp.pk/archive/2018/Nov2018/17.pdf
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http://dx.doi.org/10.29271/jcpsp.2018.11.882DOI Listing
November 2018
7 Reads

Coronary artery vasospasm in a patient withChurg-Strauss syndrome.

BMJ Case Rep 2018 Oct 25;2018. Epub 2018 Oct 25.

Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.

Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial infarction, complicated by bradycardic arrest. Read More

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http://dx.doi.org/10.1136/bcr-2018-225321DOI Listing
October 2018
3 Reads

A framework for Fourier-decomposition free-breathing pulmonary H MRI ventilation measurements.

Magn Reson Med 2019 Mar 26;81(3):2135-2146. Epub 2018 Oct 26.

Robarts Research Institute, Western University, London, Ontario, Canada.

Purpose: To develop a rapid Fourier decomposition (FD) free-breathing pulmonary H MRI (FDMRI) image processing and biomarker pipeline for research use.

Methods: We acquired MRI in 20 asthmatic subjects using a balanced steady-state free precession (bSSFP) sequence optimized for ventilation imaging. 2D H MRI series were segmented by enforcing the spatial similarity between adjacent images and the right-to-left lung volume-ratio. Read More

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http://doi.wiley.com/10.1002/mrm.27527
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http://dx.doi.org/10.1002/mrm.27527DOI Listing
March 2019
6 Reads

Pneumomediastinum, Tracheal Diverticulum, and Probable Asthma: Coincidence or Possible Association? A Case Report.

Am J Case Rep 2018 Oct 25;19:1267-1271. Epub 2018 Oct 25.

Universidad Espíritu Santo (UEES) (Holy Spirit University), Samborondón, Ecuador.

BACKGROUND Many conditions and triggers have been identified and associated with spontaneous pneumomediastinum (SPM), including asthma, strenuous exercise, chronic obstructive pulmonary disease, diabetic ketoacidosis, inhalational drugs, and other activities associated with the Valsalva maneuver. Among rare findings reported in patients with SPM is tracheal diverticulum. We present a case of SPM that on further evaluation was noted to have a tracheal diverticulum, together with a possible diagnosis of asthma. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911413
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http://dx.doi.org/10.12659/AJCR.911413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213822PMC
October 2018
8 Reads

Comparing biologicals and small molecule drug therapies for chronic respiratory diseases: An EAACI Taskforce on Immunopharmacology position paper.

Allergy 2018 Oct 24. Epub 2018 Oct 24.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), together with their comorbidities, bear a significant burden on public health. Increased appreciation of molecular networks underlying inflammatory airway disease needs to be translated into new therapies for distinct phenotypes not controlled by current treatment regimens. On the other hand, development of new safe and effective therapies for such respiratory diseases is an arduous and expensive process. Read More

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http://doi.wiley.com/10.1111/all.13642
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http://dx.doi.org/10.1111/all.13642DOI Listing
October 2018
13 Reads

[Clinical analysis of 3 cases of eosinophilic granulomatosis with polyangiitis].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Oct;41(10):783-786

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To improve the clinical recognition of eosinophilic granulomatosis with polyangiitis(EGPA) in clinical manifestations, diagnosis and treatment. The clinical manifestations, pathological characteristic, imaging manifestations, diagnosis and the therapy of three patients with EGPA were presented. These 3 patients had asthma-like symptoms and extrapulmonary manifestations of systemic vasculitis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.11.007DOI Listing
October 2018
2 Reads

Fibrosing Mediastiniti: a Rare Cause of Unilateral Absent Lung Perfusion on a V/Q Scan.

Nucl Med Mol Imaging 2018 Oct 3;52(5):401-404. Epub 2018 Sep 3.

1Division of Nuclear Medicine and Molecular Biology, Department of Radiology, Temple University Hospital, 3401 N. Broad Street, Philadelphia, PA 19104 USA.

We report a case of a 29-year-old female with a history of asthma, post-partum ARDS, and pulmonary hypertension who presents with severe shortness of breath. The patient describes her shortness of breath as progressive over the past 10 years. Chest radiography and CT angiography of the thorax showed findings consistent with fibrosing mediastinitis with severe stenosis of the left main pulmonary artery. Read More

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http://dx.doi.org/10.1007/s13139-018-0545-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177347PMC
October 2018