2,501 results match your criteria Imaging in Acute Respiratory Distress Syndrome


Venous Thromboembolism Events Following Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Syndrome Coronavirus 2 Based on CT Scans.

Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Médecine Intensive Réanimation Détresses Respiratoires et Infection Sévères, AP-HM, CHU Nord, Marseille, France.

Objectives: The main objective of the study was to determine the prevalence of venous thromboembolism events in patients infected with severe acute respiratory syndrome coronavirus 2 requiring venovenous extracorporeal membrane oxygenation. The secondary objective was to compare venous thromboembolism events and coagulation variables in patients requiring venovenous extracorporeal membrane oxygenation according to the pathogen.

Design: Retrospective observational analysis at a single center. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004504DOI Listing

E-cigarette, or vaping, product use-associated lung injury (EVALI) treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO) and ultra-protective ventilator settings.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, USA.

A 19-year-old man vaping with tetrahydrocannabinol presented with dyspnoea and right pneumothorax. History, imaging and negative infectious workup were consistent with E-cigarette, or vaping, product use-associated lung injury (EVALI). Treated with systemic steroids, he developed acute respiratory distress syndrome and was intubated requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) by hospital day 3. Read More

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http://dx.doi.org/10.1136/bcr-2020-234771DOI Listing

High Incidence of Barotrauma in Patients with COVID-19 Infection on Invasive Mechanical Ventilation.

Radiology 2020 Jul 1:202352. Epub 2020 Jul 1.

From the Department of Radiology, NYU Grossman School of Medicine, New York, NY (G.M., C.Z., L.A., M.W., D.M.M., W.H.M.), NYU Grossman School of Medicine, New York, NY (N.R.), Department of Pathology, NYU Grossman School of Medicine, New York, NY (K.M.T.), and NYU Langone Health, New York, NY (G.M., C.Z., N.R., L.A., M.W., D.M.M., K.M.T., W.H.M.).

Background We observed a high number of patients with COVID-19 pneumonia who had barotrauma related to invasive mechanical ventilation at our institution. Purpose To determine if the rate of barotrauma in patients with COVID-19 infection was greater than other patients requiring invasive mechanical ventilation at our institution. Methods In this retrospective study, clinical and imaging data of patients seen between 03/01/2020 and 04/06/2020 who tested positive for COVID-19 and experienced barotrauma associated with invasive mechanical ventilation were compared to patients without COVID-19 infection during the same period. Read More

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http://dx.doi.org/10.1148/radiol.2020202352DOI Listing

Lung ultrasound in a Singapore COVID-19 intensive care unit patient and a review of its potential clinical utility in pandemic.

J Ultrason 2020 15;20(81):e154-e158. Epub 2020 Jun 15.

Department of Anaesthesiology and Intensive Care Medicine, Seng Kang General Hospital , Singapore.

Point-of-care bedside lung ultrasound is a diagnostic adjunct in the management of respiratory diseases. We describe the clinical progress and lung ultrasound findings of a Singaporean COVID-19 intensive care unit patient who was diagnosed with COVID-19 infection. The clinical course of one COVID-19 patient managed in the intensive care unit was traced. Read More

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http://dx.doi.org/10.15557/JoU.2020.0025DOI Listing

[Acute respiratory distress in a frail older patient: spontaneous tooth aspiration].

Ned Tijdschr Tandheelkd 2020 May;127(5):282-285

A 68-year-old man presented at the emergency room with acute difficulty breathing. On account of recent subarachnoidal haemorrhage the patient was a resident of a care facility, and was also being treated for acute bronchitis there. Radiographic imaging of the lungs revealed a tooth with crown and pontic to have been inhaled. Read More

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http://dx.doi.org/10.5177/ntvt.2020.05.19132DOI Listing

Decompression illness type II with stroke: challenging situation in acute neurorehabilitation.

Int Marit Health 2020 ;71(2):105-108

Department of Neurorehabilitation, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

A professional 55-year-old female experienced diver, who surfaced after the second dive, had a lucid interval before dropping Glasgow Coma Scale (GCS) to 3/15. She was admitted to intensive care unit and commenced on hyperbaric oxygen therapy. Her initial computed tomography of the head was normal but her magnetic resonance imaging of the brain at 48 hours showed extensive bilateral cortical watershed territory infarcts. Read More

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http://dx.doi.org/10.5603/IMH.2020.0019DOI Listing
January 2020

COVID-19 associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID-19 pneumonia: An observational study from Pakistan.

Mycoses 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathology and Laboratory Medicine, Aga Khan University Karachi, Karachi, Pakistan.

Background: Invasive aspergillosis is a well-known complication of severe influenza pneumonia with acute respiratory distress syndrome (ARDS). However, recent studies are reporting emergence of aspergillosis in severe COVID-19 pneumonia, named as COVID-19 associated aspergillosis (CAPA).

Methods: A retrospective observational study was conducted in patients with severe COVID-19 pneumonia from February 2020- April 2020. Read More

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http://dx.doi.org/10.1111/myc.13135DOI Listing

Quantitative analysis of chest CT imaging findings with the risk of ARDS in COVID-19 patients: a preliminary study.

Ann Transl Med 2020 May;8(9):594

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: The coronavirus disease 2019 (COVID-19) has rapidly become a pandemic worldwide. The value of chest computed tomography (CT) is debatable during the treatment of COVID-19 patients. Compared with traditional chest X-ray radiography, quantitative CT may supply more information, but its value on COVID-19 patients was still not proven. Read More

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http://dx.doi.org/10.21037/atm-20-3554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290545PMC

A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic.

Cureus 2020 May 18;12(5):e8188. Epub 2020 May 18.

Psychiatry, Griffin Memorial Hospital, Norman, USA.

The outbreak of coronavirus disease 2019 (COVID-19) was declared a global pandemic after it spread to 213 countries and has the highest total number of cases worldwide. About 80% of COVID-19 infections are mild or asymptomatic and never require hospitalization but about 5% of patients become critically ill and develop acute respiratory distress syndrome (ARDS). The widely used management for ARDS in COVID-19 has been in line with the standard approach, but the need to adjust the treatment protocols has been questioned based on the reports of higher mortality risk among those requiring mechanical ventilation. Read More

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http://dx.doi.org/10.7759/cureus.8188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301420PMC

The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning.

Case Rep Crit Care 2020 6;2020:9270791. Epub 2020 Jun 6.

Anesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital "Pugliese-Ciaccio", Catanzaro, Italy.

Drowning is an acute respiratory failure as a result from immersion or submersion of the airways in a liquid medium (predominantly water). Inhalation of water causes severe lung damage due to the destruction of pulmonary surfactant, resulting in decreased lung elasticity, alveolar collapse, alteration of ventilation-perfusion ratio, intrapulmonary blood shunting, hypoxia, acute lung injury, and Acute Respiratory Distress Syndrome (ARDS). Poractant alfa (Curosurf®), a natural surfactant effective in the treatment of newborn respiratory distress, has been used in various forms of ARDS, but in drowning syndromes, experience is still poor. Read More

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http://dx.doi.org/10.1155/2020/9270791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294348PMC

A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application.

Med Hypotheses 2020 May 24;144:109876. Epub 2020 May 24.

Molecular Immunopharmacology & Drug Discovery Lab, Tufts University, Boston, MA 02111, USA.

The new zoonotic coronavirus (SARS-CoV-2) responsible for coronavirus disease (COVID-19) is a new strain of coronavirus not previously seen in humans and which appears to come from bat species. It originated in Wuhan, Hubei Province, China, and spread rapidly throughout the world, causing over 5,569,679 global cases and 351,866 deaths in almost every country in the world, including Europe, particularly Italy. In general, based on existing data published to date, 80. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246020PMC

In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19.

Mod Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to a global public health crisis. In elderly individuals and those with comorbidities, COVID-19 is associated with high mortality, frequently caused by acute respiratory distress syndrome. We examine in situ expression of SARS-CoV-2 in airways and lung obtained at autopsy of individuals with confirmed COVID-19 infection. Read More

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http://dx.doi.org/10.1038/s41379-020-0595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304376PMC

Unraveling the mystery of Covid-19 Cytokine storm: From skin to organ systems.

Dermatol Ther 2020 Jun 19:e13859. Epub 2020 Jun 19.

Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

COVID-19 is a global pandemic that emerged from Wuhan, China. Besides pneumonia and acute respiratory distress syndrome, the disease leads to multisystem involvement in the form of myocarditis, arrhythmias, cardiac arrest, gastrointestinal symptoms, hypoxemic brain injury, acute liver and renal function impairment. There are also reports of cutaneous lesions in form of urticarial and maculopapular rashes, chilblain like fingers and toes (covid feet), livedoid vasculopathy and chicken-pox like or varicelliform vesicles. Read More

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http://dx.doi.org/10.1111/dth.13859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323083PMC

Review of chest CT manifestations of COVID-19 infection.

Eur J Radiol Open 2020 7;7:100239. Epub 2020 Jun 7.

Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.

Coronavirus disease-19 (COVID-19) is a viral pandemic that started in China and has rapidly expanded worldwide. Typical clinical manifestations include fever, cough and dyspnea after an incubation period of 2-14 days. The diagnosis is based on RT-PCR test through a nasopharyngeal swab. Read More

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http://dx.doi.org/10.1016/j.ejro.2020.100239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276000PMC

Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study.

Int J Med Sci 2020 18;17(9):1281-1292. Epub 2020 May 18.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.

: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China. The clinical data in other centers is limited. This study aims to explore the feasible parameters which could be used in clinical practice to predict the prognosis in hospitalized patients with severe coronavirus disease-19 (COVID-19). Read More

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http://dx.doi.org/10.7150/ijms.46614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294915PMC

Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study.

Radiology 2020 06 16:202222. Epub 2020 Jun 16.

Hôpitaux Universitaires de Strasbourg, Service d'imagerie 2, Hôpital de Hautepierre, Strasbourg, France (S.K., F.L., S.B., F.D.A., T.W.); Engineering science, computer science and imaging laboratory (ICube), Integrative Multimodal Imaging in Healthcare, UMR 7357, University of Strasbourg-CNRS, Strasbourg, France (S.K.,); Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France (J.S., C.B., V.M., M.A.); CHU Rennes, Department of Neuroradiology, Rennes, France (J.C.F., B.C.N.); Service de maladies infectieuses et réanimation médicale. CHU Rennes, France (A.M.); Hôpitaux universitaires de Strasbourg, Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Strasbourg, France (O.C., P.M.M.); Service de Neuroradiologie, CHU Toulouse, Toulouse, France (F.B., G.A.); Department of infectious and tropical diseases, Toulouse University Hospital, Toulouse, France (G.M.B.); Department of Neurology, Toulouse University Hospital, Toulouse, France (M.R.); Department of Anesthesia and Critical Care, Toulouse University Hospital University Toulouse 3-Paul Sabatier, Toulouse, France (T.G., L.D.); Service de neuroradiologie diagnostique et interventionnelle, Centre Hospitalier Universitaire des Alpes, Grenoble, France (S.G., A.K.); Nephrology and Transplantation department, Hôpitaux Universitaires de Strasbourg. Inserm UMR S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France (S.C.); EA CHIMERE 7516, Université de Picardie Jules Verne, Amiens, France; Service de NeuroRadiologie, pôle Imagerie Médicale, Centre Hospitalo-Universitaire d'Amiens, Amiens, France (J.M.C., A.H.); Service de Neuro Radiologie, pôle Imagerie Médicale, Centre Hospitalo-Universitaire d'Amiens, Amiens, France (S.M.); Hôpitaux universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Strasbourg, France (J.H., F.M.); Immuno-Rhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France (J.H.); Hôpitaux universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Hautepierre, Strasbourg, France (M.S., F.C.); Service de Maladies infectieuses, NHC, CHU de Strasbourg, Strasbourg, France (N.L., Y.H.); Service de Radiologie, CHU de Saint-Etienne, Saint-Etienne, France (C.B.); Service de Réanimation, CH de Roanne, Roanne, France (X.F.); University Hospital of Limoges, Neuroradiology Department, Limoges, France (G.F., S.S.); Radiology Department, Hôpital Privé d'Antony, Antony, France (I.B., G.B.); Service d'imagerie Pédiatrique et Fœtale, Hôpital Femme Mère Enfant, HCL, Lyon, France (A.L.); Service de Neuroradiologie, Hôpitaux Civils de Colmar, Colmar, France (H.O., F.B., J.M.); INSERM U1266, Service d'imagerie morphologique et fonctionnelle, GHU Psychiatrie et Neurosciences, site Sainte-Anne, Paris, France (G.H., J.B., C.O., G.B., M.E.G., B.K.); service de Neuroradiologie, CHU Henri Mondor, Créteil, France (B.B., I.M.); Neuroradiology Unit, Department of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Bichat University Hospital, Paris, France (M.H.F., A.G.); Department of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Denis Diderot University and Medical School, Bichat University Hospital, Paris, France (A.K.); CHIC Unisanté, Hôpital Marie Madeleine, Forbach, France (L.J., P.N., Y.T.M.); service de Radiologie 1, GHR Mulhouse Sud Alsace, Hôpital Mère Enfants, Mulhouse, France (C.H., P.F., N.S.); Service de Neurologie, Centre Hospitalier de Haguenau, Haguenau, France (S.C., C.L.); Service de Radiologie, Centre Hospitalier de Haguenau, Haguenau, France (M.A.); Service de Neuroradiologie, Hôpital Central, CHU de Nancy, Nancy, France (E.S., R.A., F.Z.); Department of Neuroradiology, University Hospital of Dijon, Hôpital François Mitterrand, Dijon, France (P.C., F.R., P.T.); Department of Diagnostic and Interventional Neuroradiology, University Hospital, Nantes, France (H.D.); Neuroradiology department - CHU de Bordeaux, Bordeaux, France (J.B.); Service de Neuroradiologie, CHU de Lille, Lille, France (A.K.); Assistance Publique Hôpitaux de Paris, Service de Neuroradiologie, Hôpital Pitié-Salpêtrière, Paris, France Sorbonne Université, Univ Paris 06, UMR S 1127, CNRS UMR 7225, ICM, F-75013, Paris, France (N.P.); Neuroradiology department, Fondation A.Rothschild Hospital, Paris, France (A.L.); Hôpitaux Universitaires de Strasbourg, UCIEC, Pôle d'Imagerie, Strasbourg, France (P.E.Z., M.M.); Observatoire Français de la Sclérose en Plaques, Lyon, France (J.C.B.); Hôpitaux universitaires de Strasbourg, Laboratoire de Virologie Médicale, Strasbourg, France (S.F.K.); Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France (M.O.); INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France (F.M.); Department of Anaesthesia and Intensive Care, Lyon-Sud Hospital, Hospices Civils de Lyon, F-69495 Pierre Benite; University Claude Bernard Lyon 1, Lyon, France (J.S.D.); CHU de Strasbourg, Service de Santé Publique, GMRC, F-67091 Strasbourg, France (N.M.); Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM-U964/CNRSUMR7104/Université de Strasbourg, Illkirch, France (M.A.); MRI center, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France (F.C.); Université Lyon 1, CREATIS-LRMN, CNRS/UMR/5220-INSERM U630, Villeurbanne, France (F.C.).

Background Brain MRI parenchymal signal abnormalities have been in association with SARS-CoV-2. Purpose Describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe COVID-19 infection. Methods This was a retrospective study of patients evaluated from March 23th, 2020 to April 27th, 2020 at 16 hospitals. Read More

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http://dx.doi.org/10.1148/radiol.2020202222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301613PMC

Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit.

JAMA Netw Open 2020 06 1;3(6):e2012270. Epub 2020 Jun 1.

Department of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan.

Importance: In late December 2019, an outbreak caused by a novel severe acute respiratory syndrome coronavirus 2 emerged in Wuhan, China. Data on the clinical characteristics and outcomes of infected patients in urban communities in the US are limited.

Objectives: To describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and to perform a comparative analysis of hospitalized and ambulatory patient populations. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.12270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298606PMC

Acute pneumonitis and diffuse alveolar hemorrhage secondary to silicone embolism: A case report.

Medicine (Baltimore) 2020 Jun;99(24):e20578

Faculty of Health Sciences, Universidad Icesi.

Rationale: Polydimethylsiloxane, commonly referred as silicone, is an inert liquid compound used in esthetic procedures due to its durability and thermal stability, yet the application of non-pure silicone generates risks. One of the complications is systemic embolism syndrome which is presents with fever, hypoxemia, and progression to respiratory failure, diffuse alveolar damage and alveolar hemorrhage, as well as neurological alterations in one-third of the cases. Management is strictly supportive. Read More

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http://dx.doi.org/10.1097/MD.0000000000020578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302641PMC

Aetiology and short-term outcome of acute respiratory distress syndrome: a real-world experience from a medical intensive care unit in southern India.

J R Coll Physicians Edinb 2020 03;50(1):12-18

Department of Medicine, JIPMER, Puducherry.

Background: Acute respiratory distress syndrome (ARDS) is a highly fatal syndrome especially in resource constrained settings. In this study we prospectively studied the aetiology of ARDS and its short-term outcome.

Methods: Consecutive adults with suspected ARDS were screened. Read More

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http://dx.doi.org/10.4997/JRCPE.2020.104DOI Listing

Clinical and radiological features of novel coronavirus pneumonia.

J Xray Sci Technol 2020 ;28(3):391-404

Department of Medical Imaging, Shenzhen Center for Chronic Disease Control, Guangdong Shenzhen 518020, China.

Recently, COVID-19 has spread in more than 100 countries and regions around the world, raising grave global concerns. COVID-19 transmits mainly through respiratory droplets and close contacts, causing cluster infections. The symptoms are dominantly fever, fatigue, and dry cough, and can be complicated with tiredness, sore throat, and headache. Read More

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http://dx.doi.org/10.3233/XST-200687DOI Listing
January 2020

Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290137PMC
June 2020
2.117 Impact Factor

Bedside veno-venous ECMO cannulation: A pertinent strategy during the COVID-19 pandemic.

J Card Surg 2020 Jun;35(6):1180-1185

Division of Pulmonary and Critical Care, Department of Emergency Medicine, Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota.

Background: Patient selection and cannulation arguably represent the key steps for the successful implementation of extracorporeal membrane oxygenation (ECMO) support. Cannulation is traditionally performed in the operating room or the catheterization laboratory for a number of reasons, including physician preference and access to real-time imaging, with the goal of minimizing complications and ensuring appropriate cannula positioning. Nonetheless, the patients' critical and unstable conditions often require emergent initiation of ECMO and preclude the safe transport of the patient to a procedural suite. Read More

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http://dx.doi.org/10.1111/jocs.14641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323207PMC

A Case Series of Patients Coinfected With Influenza and COVID-19.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620934674

Interfaith Medical Center, Brooklyn, NY, USA.

Coronavirus disease 2019, also called COVID-19, is a global pandemic resulting in significant morbidity and mortality worldwide. In the United States, influenza infection occurs mainly during winter and several factors influence the burden of the disease, including circulating virus characteristics, vaccine effectiveness that season, and the duration of the season. We present a case series of 3 patients with coinfection of COVID-19 and influenza, with 2 of them treated successfully and discharged home. Read More

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http://dx.doi.org/10.1177/2324709620934674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290261PMC

Case 18-2020: A 73-Year-Old Man with Hypoxemic Respiratory Failure and Cardiac Dysfunction.

N Engl J Med 2020 Jun;382(24):2354-2364

From the Departments of Medicine (D.S.K., L.M.M., D.S.P., P.J.Z.) and Radiology (D.L.), Beth Israel Deaconess Medical Center, the Departments of Medicine (D.S.K., L.M.M., D.S.P., P.J.Z., D.M.D.) and Radiology (D.L.), Harvard Medical School, and the Department of Medicine, Massachusetts General Hospital (D.M.D.) - all in Boston; and the Department of Medicine, New York Presbyterian-Columbia University Medical Center, and the Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons - both in New York (K.J.C.).

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http://dx.doi.org/10.1056/NEJMcpc2002417DOI Listing

Significance of clinical phenomes of patients with COVID-19 infection: A learning from 3795 patients in 80 reports.

Clin Transl Med 2020 Jan 4;10(1):28-35. Epub 2020 Apr 4.

Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai, China.

A new coronavirus SARS-CoV-2 has caused outbreaks in multiple countries and the number of cases is rapidly increasing through human-to-human transmission. Clinical phenomes of patients with SARS-CoV-2 infection are critical in distinguishing it from other respiratory infections. The extent and characteristics of those phenomes varied depending on the severities of the infection, for example, beginning with fever or a mild cough, progressed with signs of pneumonia, and worsened with severe or even fatal respiratory difficulty in acute respiratory distress syndrome. Read More

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http://dx.doi.org/10.1002/ctm2.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240842PMC
January 2020

[Covid-19 - radiologic and histologic features].

Lakartidningen 2020 06 1;117. Epub 2020 Jun 1.

docent, specialistläkare, Lunds universitet; Klinisk patologi, Lund; Karolinska universitetssjukhuset, Solna.

We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. Read More

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Treatment algorithm for COVID-19: a multidisciplinary point of view.

Clin Rheumatol 2020 Jul 29;39(7):2077-2084. Epub 2020 May 29.

Department of Anesthesia and Reanimation, Hospital Universitario Mostoles, Madrid, Spain.

The novel coronavirus (Sars-CoV-2) pandemic has spread rapidly, from December to the end of March, to 185 countries, and there have been over 3,000,000 cases identified and over 200,000 deaths. For a proportion of hospitalized patients, death can occur within a few days, mainly for adult respiratory distress syndrome or multi-organ dysfunction syndrome. In these patients, clinical signs and symptoms, as well as laboratory abnormalities, suggest a cytokine storm syndrome in response to the viral infection. Read More

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http://dx.doi.org/10.1007/s10067-020-05179-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255973PMC
July 2020
1.774 Impact Factor

Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis.

PLoS One 2020 29;15(5):e0233864. Epub 2020 May 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brasil.

Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233864PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259762PMC

Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925978

SUNY Upstate Medical University, Syracuse, NY, USA.

Idiopathic acute eosinophilic pneumonia (AEP) is a very rare disease with fewer than 200 cases reported. It has been hypothesized to be a hypersensitivity reaction to an unidentified antigen. The clinical presentation typically involves fever, nonproductive cough, shortness of breath, and bibasilar inspiratory crackles within the first week of antigen exposure. Read More

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http://dx.doi.org/10.1177/2324709620925978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262976PMC

The importance of anti-vaping vigilance-EVALI in seven adolescent pediatric patients in Northeast Ohio.

Pediatr Pulmonol 2020 Jul 3;55(7):1719-1724. Epub 2020 Jun 3.

Centre for Pediatric Pulmonary Medicine, Cleveland Clinic Children's, Cleveland, Ohio.

As of 18 February 2020, the e-cigarette or vaping product use-associated lung injury (EVALI) epidemic has claimed the lives of 68 patients in the USA with the total number of reported cases standing at 2807 to date. We present the clinical and radiologic findings, course of illness, and treatment of EVALI in seven adolescent patients in Northeast Ohio. Five of our patients required supplemental oxygen with four requiring intensive care unit care for respiratory support during admission. Read More

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http://dx.doi.org/10.1002/ppul.24872DOI Listing

Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID-19).

JPEN J Parenter Enteral Nutr 2020 May 27. Epub 2020 May 27.

Professor of Medicine, Division of Gastroenterology Hepatology and Nutrition, University of Louisville, School of Medicine, Louisville, Kentucky, USA.

In the midst of a worldwide pandemic of the Coronavirus Disease 2019 (COVID-19), a paucity of data precludes derivation of COVID-19-specific recommendations for nutritional therapy. Until more data are available, the focus needs to center on principles of critical care nutrition modified for the constraints of this disease process, i.e. Read More

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http://dx.doi.org/10.1002/jpen.1930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283713PMC

Accurate positioning of extracorporeal membrane oxygenation cannulas using real-time trans-thoracic echocardiography.

Perfusion 2020 May 27:267659120919658. Epub 2020 May 27.

Medical Intensive Care Unit, Soroka University Medical Center, Beer-Sheva, Israel.

In this retrospective observational case series, we aimed to evaluate the use of real-time trans-thoracic echocardiography in accurate positioning of extracorporeal membrane oxygenation cannulas. Patients admitted to the intensive care unit with severe adult respiratory distress syndrome in need for extracorporeal membrane oxygenation were screened. Twenty-one extracorporeal membrane oxygenation cannulas were inserted in 10 patients, and 95% of the cannulas were located exactly at the vena cava-right atria junction as planned. Read More

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http://dx.doi.org/10.1177/0267659120919658DOI Listing

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach.

Cardiorenal Med 2020 May 27:1-8. Epub 2020 May 27.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Read More

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http://dx.doi.org/10.1159/000508544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316643PMC

Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

Cureus 2020 May 19;12(5):e8198. Epub 2020 May 19.

Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.

The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies, cutaneous manifestations, and ultimately death from multi-organ failure. Unfortunately, the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions, especially in symptomatic patients. Read More

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http://dx.doi.org/10.7759/cureus.8198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243064PMC

Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study.

Intensive Care Med 2020 Jul 25;46(7):1382-1393. Epub 2020 May 25.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA, USA.

Purpose: Definitions of acute respiratory distress syndrome (ARDS) include radiographic criteria, but there are concerns about reliability and prognostic relevance. This study aimed to evaluate the independent relationship between chest imaging and mortality and examine the inter-rater variability of interpretations of chest radiographs (CXR) in pediatric ARDS (PARDS).

Methods: Prospective, international observational study in children meeting Pediatric Acute Lung Injury Consensus Conference (PALICC) criteria for PARDS, which requires new infiltrate(s) consistent with pulmonary parenchymal disease, without mandating bilateral infiltrates. Read More

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http://dx.doi.org/10.1007/s00134-020-06074-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246298PMC

Analysis of the clinical characteristics, drug treatments and prognoses of 136 patients with coronavirus disease 2019.

J Clin Pharm Ther 2020 May 25. Epub 2020 May 25.

Pharmaceutical Department, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.

What Is Known And Objective: Since the December 2019 discovery of several cases of coronavirus disease 2019 (COVID-19) in Wuhan, China, the infection has spread worldwide. Our aim is to report on the clinical characteristics, treatments and prognoses of COVID-19.

Methods: This was a retrospective, single-centre, case series of 136 patients who were diagnosed with COVID-19 at Wuhan Third Hospital in Wuhan, China, between 28 January 2020 and 12 February 2020. Read More

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http://dx.doi.org/10.1111/jcpt.13170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283656PMC

Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome.

Lung Cancer 2020 Jul 30;145:132-139. Epub 2020 Apr 30.

Department of Imaging, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Objective: Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death.

Methods: Eighty-two patients with lung cancer treated with conventional chest radiotherapy who had symptomatic RP were identified from the radiation oncology database. The imaging features of RP were studied for association with high-grade RP (Grade ≥3) and RP-related death (Grade 5). Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316126PMC

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

N Engl J Med 2020 May 21. Epub 2020 May 21.

From the Institute of Pathology and Department of Molecular Pathology, Helios University Clinic Wuppertal, University of Witten-Herdecke, Wuppertal (M.A.), the Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz (M.A.), the Institute of Pathology (M.K., F.L., C.W., H.S., D.J.), the Department of Cardiothoracic, Transplantation, and Vascular Surgery (A.H.), and the Clinic of Pneumology (T.W.), Hannover Medical School, and the German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) (M.K., A.H., T.W., F.L., C.W., H.S., D.J.), Hannover - all in Germany; the Laboratory of Respiratory Diseases, BREATH, Department of Chronic Diseases, Metabolism, and Aging, KU Leuven, Leuven, Belgium (S.E.V., A.V.); the Institute of Pathology and Medical Genetics, University Hospital Basel, Basel, Switzerland (A.T.); and the Angiogenesis Foundation, Cambridge (W.W.L., V.W.L.), and the Laboratory of Adaptive and Regenerative Biology and the Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston (S.J.M.) - all in Massachusetts.

Background: Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19.

Methods: We examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection and 10 age-matched, uninfected control lungs. Read More

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http://dx.doi.org/10.1056/NEJMoa2015432DOI Listing

A novel coronavirus (SARS-CoV-2) and COVID-19.

Cas Lek Cesk 2020 ;159(2):55-66

By the end of 2019 the first cases of severe pneumonia of unknown origin were reported in Wuhan, China. The causative agent was identified as a novel b-coronavirus SARS-CoV-2 and the disease was named COVID-19. Since the beginning of 2020, the infection has spread worldwide, which led the WHO to declare COVID-19 a public health emergency of international concern and to characterize the current situation as a pandemic. Read More

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Early Multi-organ Point-of-Care Ultrasound Evaluation of Respiratory Distress During SARS-CoV-2 Outbreak: Case Report.

Clin Pract Cases Emerg Med 2020 May 15;4(2):129-133. Epub 2020 Apr 15.

Highland Hospital / Alameda Health System, Department of Emergency Medicine, Oakland, California.

Introduction: Coronavirus disease 2019 (COVID-19) is caused by the virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several case series from Italy and China have highlighted the lung ultrasound findings of this disease process and may demonstrate its clinical utility during the current pandemic.

Case Report: We present a case of a COVID-19 patient who presented to the emergency department twice within a 24-hour period with rapidly progressing illness. Read More

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http://dx.doi.org/10.5811/cpcem.2020.4.47524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220010PMC

Coronavirus Disease 2019-related dyspnea cases difficult to interpret using chest computed tomography.

Respir Med 2020 06 6;167:105951. Epub 2020 Apr 6.

Department of Respiratory Disease and Intensive Care, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address:

Patients with Coronavirus Disease 2019 (COVID-19) often have clinical characteristics, such as chest tightness and dyspnea. Continuous, unresolved dyspnea often indicates the progression of lung lesions. The mechanism that underlies the chest distress and dyspnea in patients with COVID-19 is still unclear. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195086PMC

Steroid-Responsive Encephalitis in Coronavirus Disease 2019.

Ann Neurol 2020 May 17. Epub 2020 May 17.

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Read More

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http://dx.doi.org/10.1002/ana.25783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276848PMC

Delivering urgent urological surgery during the COVID-19 pandemic in the United Kingdom: Outcomes from our initial 52 patients.

BJU Int 2020 May 14. Epub 2020 May 14.

Urology Department, Royal Hampshire County Hospital, Romsey Rd, Winchester, SO22 5DG, United Kingdom.

Since first reported in December 2019, the novel RNA betacoronavirus disease (COVID-19) has spread rapidly across the world with, as of the 3rd May 2020, 3.3 million confirmed cases with more than 230,000 deaths worldwide and more than 200 countries affected. The most common symptoms reported include dry cough, fever and fatigue with ground-glass opacification bilaterally in the lungs on imaging and lymphopenia on haematological analysis. Read More

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http://dx.doi.org/10.1111/bju.15110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272877PMC

Clinical Course, Imaging Features, and Outcomes of COVID-19 in Kidney Transplant Recipients.

Eur Urol 2020 May 6. Epub 2020 May 6.

Department of Radiology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Coronavirus disease 2019 (COVID-19) is a novel and highly contagious disease caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older adults and patients with comorbidities and immunosuppressive conditions may experience severe signs and symptoms that can lead to death. This case series assesses the clinical course, imaging features, and outcomes for 12 patients with COVID-19 and a history of kidney transplantation. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.04.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200360PMC
May 2020
13.938 Impact Factor

Hypogeusia as the initial presenting symptom of COVID-19.

BMJ Case Rep 2020 May 13;13(5). Epub 2020 May 13.

Department of Internal Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.

COVID-19 is the disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first arose in Wuhan, China, in December 2019 and has since been declared a pandemic. The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory distress, acute cardiopulmonary arrest and death. Otolaryngologists around the globe have reported a significant number of mild or otherwise asymptomatic patients with COVID-19 presenting with olfactory dysfunction. Read More

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http://dx.doi.org/10.1136/bcr-2020-236080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228456PMC

Lung ultrasound in the monitoring of COVID-19 infection.

Authors:
Yale Tung-Chen

Clin Med (Lond) 2020 May 12. Epub 2020 May 12.

Hospital Universitario La Paz, Madrid, Spain and associate professor, Universidad Alfonso X El Sabio, Madrid, Spain

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pneumonia and acute respiratory distress syndrome (ARDS) are the most common severe complications. There is growing evidence regarding the imaging findings of COVID-19 in chest X-rays and computed tomography (CT) scans; however, their availability to clinical staff in this pandemic outbreak might be compromised. Read More

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http://dx.doi.org/10.7861/clinmed.2020-0123DOI Listing

The emerging role of lung ultrasound in COVID-19 pneumonia.

Eur J Rheumatol 2020 May 7. Epub 2020 May 7.

Division of Rheumatology, Department of Experimental and Clinical Medicine, Università degli Studi di Firenze, Firenze, Toscana, Italy.

In the last decades lung ultrasound (LUS) has become of crucial importance in the evaluation and monitoring of a widely range of pulmonary diseases. One of the major benefits which favours this examination, is that this is a non-invasive, low-cost and radiation-free imaging modality which allows repeated imaging. LUS plays an important role in a wide range of pathologies, including cardiogenic oedema, acute respiratory distress syndrome and fibrosis. Read More

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http://dx.doi.org/10.5152/eurjrheum.2020.2063DOI Listing

Novel coronavirus 2019 (COVID-19): A case report and review of treatments.

Medicine (Baltimore) 2020 May;99(19):e20207

Department of Medicine, Hackensack Meridian School of Medicine at Seton Hall University Nutley.

Rationale: Novel coronavirus 2019 (COVID-19) also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, non-segmented positive-sense RNA virus belonging to the beta-coronaviridae family. This virus is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS) which can lead to difficulty breathing requiring mechanical ventilation and intensive care unit management.

Patient Concerns: A 77-year-old female with a history of hypertension and hyperlipidemia who presented as a transfer to our hospital facility with worsening fevers, cough, and respiratory distress. Read More

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http://dx.doi.org/10.1097/MD.0000000000020207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220032PMC

Acute respiratory failure in COVID-19: is it "typical" ARDS?

Authors:
Xu Li Xiaochun Ma

Crit Care 2020 05 6;24(1):198. Epub 2020 May 6.

Department of Critical Care Medicine, the First Affiliated Hospital, China Medical University, North Nanjing Street 155, Shenyang, 110001, Liaoning Province, People's Republic of China.

In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) was identified in Wuhan, China. The World Health Organization (WHO) declared this outbreak a significant threat to international health. COVID-19 is highly infectious and can lead to fatal comorbidities especially acute respiratory distress syndrome (ARDS). Read More

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http://dx.doi.org/10.1186/s13054-020-02911-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202792PMC

Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report.

A A Pract 2020 May;14(7):e01227

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A 17-year-old healthy girl underwent an uneventful esthetic septorhinoplasty. She was easily extubated and transferred to the postanesthesia care unit (PACU) with oxygen saturation (SpO2) of 96%. About 30 minutes after arrival in the PACU, she developed dyspnea with SpO2 of 84% and promptly received oxygen with bilevel positive airway pressure in conjunction with low-dose corticosteroid. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227797PMC