4,884 results match your criteria Imaging in Acute Respiratory Distress Syndrome

Rare cause of diffuse alveolar haemorrhage and subconjunctival haemorrhage rescued by extracorporeal membrane oxygenation and rituximab.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Rheumatology, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

A previously healthy man in his 20s presented with acute respiratory distress syndrome and subconjunctival haemorrhage. Imaging was indicative of pervasive pulmonary haemorrhage. There was no evidence of renal involvement. Read More

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Development of the Sepsis-Associated Adverse Outcomes in Pregnancy Score.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Obstetrics & Gynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, United States.

Objective: To develop and evaluate a scoring system-called Sepsis-Associated Adverse Outcomes in Pregnancy (SAAP) Score-to identify individuals with maternal infection that have composite maternal adverse outcomes (CMAO).

Study Design: Using ICD codes, we identified pregnant and postpartum (up to 6 weeks after birth) individuals admitted at our center with a primary diagnosis of infection. The primary outcome was CMAO, which included any of the following: maternal intensive care unit admission, surgical intervention, vasopressor use, acute respiratory distress syndrome, pulmonary edema, mechanical ventilation, high flow nasal cannula, disseminated intravascular coagulation, dialysis, organ failure, venous thromboembolism, or maternal death. Read More

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Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction.

Proc Natl Acad Sci U S A 2022 Jul 24;119(28):e2202370119. Epub 2022 Jun 24.

UMR 5234, Microbiologie Fondamentale et Pathogénicité, CNRS, Université de Bordeaux, 33076 Bordeaux, France.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome with a high degree of mortality in elderly patients. We used reconstituted primary bronchial epithelia from adult and child donors to follow the SARS-CoV-2 infection dynamics. We show that, in epithelia from adult donors, infections initiate in multiciliated cells and spread within 24 to 48 h throughout the whole epithelia. Read More

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Gadolinium in Medical Imaging-Usefulness, Toxic Reactions and Possible Countermeasures-A Review.

Biomolecules 2022 May 24;12(6). Epub 2022 May 24.

Department of Research, Innlandet Hospital Trust, P.O. Box 104, N-2381 Brumunddal, Norway.

Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic resonance imaging. Such Gd-chelates have been used for more than thirty years. Read More

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Postmortem computed tomography plus forensic autopsy for determining the cause of death in child fatalities.

Pediatr Radiol 2022 Jun 23. Epub 2022 Jun 23.

University of Sheffield and Sheffield Children's NHS Foundation Trust, Sheffield, UK.

Background: Postmortem computed tomography (CT) and magnetic resonance imaging have been gradually introduced to forensic pathology centres over the past two decades, with varying results in comparison to autopsy.

Objective: The purpose of this study was to determine the accuracy of postmortem CT in determining a cause of death in children who died of unnatural causes.

Materials And Methods: This was a prospective recruitment of 30 children (< 18 years) who underwent postmortem CT and a forensic autopsy. Read More

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[Correlation between dead space fraction and pulmonary ultrasound score in patients with acute respiratory distress syndrome and its prognostic value].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 May;34(5):514-518

Intensive Care Unit, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, Liaoning, China. Corresponding author: Chu Yun, Email:

Objective: To investigate the correlation between dead space fraction and lung ultrasound score (LUS) and their prognostic value in patients with acute respiratory distress syndrome (ARDS).

Methods: The data of 98 patients with ARDS treated in the intensive care unit (ICU) of the First Affiliated Hospital of Jinzhou Medical University from January to December 2020 were collected and analyzed. The gender, age, acute physiology and chronic health evaluation II (APACHE II), oxygenation index, dead space fraction and LUS score immediately and 24, 48, 72 and 96 hours after ICU admission and 28-day outcomes of all patients were collected. Read More

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Lung Ultrasound and Electrical Impedance as Long-Term Monitoring Tools for Acute Respiratory Failure: Sometimes No Numbers Are Better Than Bad (or Confusing) Numbers.

Crit Care Med 2022 Jul 13;50(7):1167-1170. Epub 2022 Jun 13.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

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Tools for assessing lung fluid in neonates with respiratory distress.

BMC Pediatr 2022 Jun 20;22(1):354. Epub 2022 Jun 20.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Transient tachypnea of the newborn (TTN), as a common cause of neonatal respiratory distress, needs to be distinguished from respiratory distress syndrome (RDS). Various modalities such as lung ultrasonography, cytokine analysis, and electrical cardiometry for the evaluation of lung fluid can be helpful for the exact diagnosis, however, clinical diagnosis has been applied mainly. This study aimed to evaluate the usefulness of the various tools for the diagnosis of TTN and RDS in neonates. Read More

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Splenic Artery Embolization and Splenectomy for Spontaneous Rupture of Splenic Hemangioma and Its Imaging Features.

Front Cardiovasc Med 2022 3;9:925711. Epub 2022 Jun 3.

Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Background: Spontaneous splenic rupture (SSR) is a rare, often life-threatening, acute abdominal injury that requires immediate diagnosis and early treatment. SSR is mainly treated surgically or conservatively. A few cases of interventional embolization for SSRs have been reported. Read More

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Pediatric lung ultrasonography: current perspectives.

Pediatr Radiol 2022 Jun 18. Epub 2022 Jun 18.

Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Ultrasonography (US) is the workhorse of pediatric imaging; however, lung US is only a recently developed application. US of the lung is based predominantly on the imaging of chest wall-air-fluid interfaces. In this review, we summarize the available literature on applications of lung US in neonatal as well as pediatric care. Read More

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Concomitant post-traumatic ocular and cerebral fat embolism syndrome and thrombotic pulmonary embolism: A case report.

Medicine (Baltimore) 2022 Jun 17;101(24):e29331. Epub 2022 Jun 17.

Department of Orthopedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Rationale: Fat embolism syndrome (FES) is composed of a triad of symptoms, including respiratory distress, neurologic deficit, and petechiae. Respiratory distress usually presents first before the other symptoms. Thrombotic pulmonary embolism (TPE) is a differential diagnosis of FES. Read More

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Detection of residual pulmonary alterations with lung ultrasound and effects on postoperative pulmonary complications for patients with asymptomatic SARS-CoV-2 infection undergoing surgeries.

BMC Anesthesiol 2022 Jun 16;22(1):186. Epub 2022 Jun 16.

Department of Anesthesiology, Hospital Universitari Vall d'Hebron, Passeig de la Vall d'Hebron 119, 08035, Barcelona, Spain.

Background: For patients with a clinical course of active SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection, there may be a higher risk of perioperative complications. Our main objective is to detect the residual pulmonary alterations in asymptomatic patients after SARS-CoV-2 infection undergoing surgery and determine their relationship with the clinical course of SARS-CoV-2 infection. The secondary aim is to investigate whether the presence of residual pulmonary alterations have any affects on the severity of postoperative pulmonary complications. Read More

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Pulmonary and Systemic Pathology in COVID-19-Holistic Pathological Analyses.

Dtsch Arztebl Int 2022 Jun 24(Forthcoming). Epub 2022 Jun 24.

Background: The COVID-19 pandemic is the third worldwide coronavirus-associated disease outbreak in the past 20 years. Lung involvement, with acute respiratory distress syndrome (ARDS) in severe cases, is the main clinical feature of this disease; the cardiovascular system, the central nervous system, and the gastrointestinal tract can also be affected. The pathophysiology of both pulmonary and extrapulmonary organ damage was almost completely unknown when the pandemic began. Read More

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Neonatal Joubert Syndrome With Renal Involvement and Respiratory Distress.

Cureus 2022 May 11;14(5):e24907. Epub 2022 May 11.

Radiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

Joubert syndrome (JS) is a rare autosomal recessive neurodevelopmental disorder with characteristic clinical presentation of hyperpnea-apnea spells, hypotonia, dysmorphic facies, and nystagmus and imaging features of molar tooth sign and cerebellar vermian hypoplasia-dysplasia. Early diagnosis is needed for timely management and favorable outcome. We present a case of neonatal JS with renal involvement presenting with respiratory distress and highlight the characteristic clinical and imaging findings. Read More

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Predictive value of computed tomography for short-term mortality in patients with acute respiratory distress syndrome: a systematic review.

Sci Rep 2022 Jun 10;12(1):9579. Epub 2022 Jun 10.

Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The best available evidence and the predictive value of computed tomography (CT) findings for prognosis in patients with acute respiratory distress syndrome (ARDS) are unknown. We systematically searched three electronic databases (MEDLINE, CENTRAL, and ClinicalTrials.gov). Read More

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Insights Regarding the Berlin Definition of ARDS from Prospective Observational Studies.

Semin Respir Crit Care Med 2022 Jun 9. Epub 2022 Jun 9.

Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland.

The definition of acute respiratory distress syndrome (ARDS), has evolved since it was first described in 1967 by Ashbaugh and Petty to the current "Berlin" definition of ARDS developed in 2012 by an expert panel, that provided clarification on the definition of "acute," and on the cardiac failure criteria. It expanded the definition to include patients receiving non-invasive ventilation, and removed the term "acute lung injury" and added a requirement of patients to be receiving a minimum 5 cmHO expiratory pressure.Since 2012, a series of observational cohort studies have generated insights into the utility and robustness of this definition. Read More

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Experimental Models to Study the Pathogenesis of Malaria-Associated Acute Respiratory Distress Syndrome.

Front Cell Infect Microbiol 2022 23;12:899581. Epub 2022 May 23.

Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is increasingly gaining recognition as a severe malaria complication because of poor prognostic outcomes, high lethality rate, and limited therapeutic interventions. Unfortunately, invasive clinical studies are challenging to conduct and yields insufficient mechanistic insights. These limitations have led to the development of suitable MA-ARDS experimental mouse models. Read More

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Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS.

Am J Respir Crit Care Med 2022 Jun 7. Epub 2022 Jun 7.

Massachusetts General Hospital, 2348, James Homer Wright Pathology Laboratories, Department of Pathology, Boston, Massachusetts, United States.

Rationale The leading cause of death in coronavirus disease 2019(COVID-19) is severe pneumonia, with many patients developing acute respiratory distress syndrome(ARDS) and diffuse alveolar damage(DAD). Whether DAD in fatal COVID-19 is distinct from other causes of DAD remains unknown. Objective To compare lung parenchymal and vascular alterations between patients with fatal COVID-19 pneumonia and other DAD-causing etiologies using a multidimensional approach. Read More

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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.

BMJ Open 2022 Jun 6;12(6):e060664. Epub 2022 Jun 6.

Nephrology, University of California San Francisco, San Francisco, California, USA.

Introduction: The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021. Read More

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Normalizing the Abnormal: Hypoxemia in Venovenous ECMO.

J Cardiothorac Vasc Anesth 2022 Aug 7;36(8 Pt B):3433-3434. Epub 2022 May 7.

Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, MA.

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COVID-19-induced silent myocarditis and newly developed hypertension in a 3-year-old boy.

Egypt Heart J 2022 May 31;74(1):44. Epub 2022 May 31.

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: COVID-19 myocarditis occurs in 7-28% of patients admitted in the hospital with or without multisystem inflammatory syndrome. It may present as fulminant myocarditis. Dilated cardiomyopathy as a sequela of COVID-19 myocarditis has been reported in the pediatric population. Read More

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Lung ultrasound in Italian neonatal intensive care units: A national survey.

Pediatr Pulmonol 2022 May 30. Epub 2022 May 30.

Department of Neurosciences Psychology Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Introduction: Lung ultrasound (LU) is a noninvasive, bedside imaging technique that is attracting growing interest in the evaluation of neonatal respiratory diseases. We conducted a nationwide survey of LU usage in Italian neonatal intensive care units (NICUs).

Methods: A structured questionnaire was developed and sent online to 114 Italian NICUs from June to September 2021. Read More

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Nutritional Risk Assessment Scores Effectively Predict Mortality in Critically Ill Patients with Severe COVID-19.

Nutrients 2022 May 18;14(10). Epub 2022 May 18.

Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Background: Malnutrition predicts a worse outcome for critically ill patients. However, quick, easy-to-use nutritional risk assessment tools have not been adequately validated.

Aims And Methods: The study aimed to evaluate the role of four biological nutritional risk assessment instruments (the Prognostic Nutritional Index-PNI, the Controlling Nutritional Status Score-CONUT, the Nutrition Risk in Critically Ill-NUTRIC, and the modified NUTRIC-mNUTRIC), along with CT-derived fat tissue and muscle mass measurements in predicting in-hospital mortality in a consecutive series of 90 patients hospitalized in the intensive care unit for COVID-19-associated ARDS. Read More

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Inhaled nitric oxide as temporary respiratory stabilization in patients with COVID-19 related respiratory failure (INOCOV): Study protocol for a randomized controlled trial.

PLoS One 2022 27;17(5):e0268822. Epub 2022 May 27.

Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: In March 2020, WHO announced the COVID-19 a pandemic and a major global public health emergency. Mortality from COVID-19 is rapidly increasing globally, with acute respiratory failure as the predominant cause of death. Many patients experience severe hypoxia and life-threatening respiratory failure often requiring mechanical ventilation. Read More

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Spinal muscular atrophy with respiratory distress type 1 (SMARD1): a rare cause of hypotonia, diaphragmatic weakness, and respiratory failure in infants.

Turk J Pediatr 2022 ;64(2):364-374

Department of Pediatric Neurology, University of Health Sciences, Dr. Behçet Uz Children's Education and Research Hospital, İzmir.

Background: Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a very rare autosomal recessive disorder caused by mutations in the immunoglobulin μ-binding protein-2 (IGHMBP2) gene on chromosome 11q13.2-q13.4. Read More

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Electrical Impedance Tomography in Acute Respiratory Distress Syndrome Management.

Crit Care Med 2022 May 23. Epub 2022 May 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Objective: To describe, through a narrative review, the physiologic principles underlying electrical impedance tomography, and its potential applications in managing acute respiratory distress syndrome (ARDS). To address the current evidence supporting its use in different clinical scenarios along the ARDS management continuum.

Data Sources: We performed an online search in Pubmed to review articles. Read More

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Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a multicentre prospective cohort study.

Anaesthesia 2022 07 24;77(7):772-784. Epub 2022 May 24.

Department of Anaesthesia, Golden Jubilee National Hospital, Clydebank, UK.

Cardiovascular complications due to COVID-19, such as right ventricular dysfunction, are common. The combination of acute respiratory distress syndrome, invasive mechanical ventilation, thromboembolic disease and direct myocardial injury creates conditions where right ventricular dysfunction is likely to occur. We undertook a prospective, multicentre cohort study in 10 Scottish intensive care units of patients with COVID-19 pneumonitis whose lungs were mechanically ventilated. Read More

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Clinical Outcome Discrimination in Pediatric ARDS by Chest Radiograph Severity Scoring.

Can Respir J 2022 14;2022:9309611. Epub 2022 May 14.

Department of Radiology, The Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing, China.

Background: There is no accurate radiological measurement to estimate the severity of pediatrics acute respiratory distress syndrome (PARDS). We validated the effectiveness of an adult radiographic assessment of lung edema (RALE) score in PARDS.

Aim: To assess the severity and prognosis of PARDS based on a chest radiograph (CXR) RALE scoring method. Read More

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Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS.

Emerg Microbes Infect 2022 Dec;11(1):1537-1549

Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.

There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n = 167) and a group of infected patients who did not develop ARDS (n = 33). Read More

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December 2022