4,426 results match your criteria Imaging in Acute Respiratory Distress Syndrome

The influence of extracellular tissue on neutrophil function and its possible linkage to inflammatory diseases.

Immun Inflamm Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Anaesthesiology, University Medical Centre Regensburg, Regensburg, Germany.

Background: Migration, production of reactive oxygen species (ROS), release of myeloperoxidase (MPO), and NETosis are functional immunological reactions of elementary importance for polymorphonuclear neutrophils (PMN). Unregulated inflammatory response of PMN within tissues plays a key role in the pathophysiology of several diseases. However, little is known about the behavior of PMN after migration through blood vessel walls. Read More

View Article and Full-Text PDF

[Value of radiographic assessment of lung edema score in evaluating the severity and prognosis of patients with acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):557-562

Department of Intensive Care Unit, Affiliated Nantong Third Hospital of Nantong University (Nantong Third People's Hospital), Nantong 226000, Jiangsu, China.

Objective: To explore the value of radiographic assessment of lung edema (RALE) score in evaluating the severity and prognosis of patients with acute respiratory distress syndrome (ARDS).

Methods: A retrospective study was conducted. Patients with ARDS admitted to the department of intensive care unit (ICU) of Affiliated Nantong Third Hospital of Nantong University from January 2016 to November 2020 were enrolled. Read More

View Article and Full-Text PDF

Automatic Detection of Coronavirus Disease (COVID-19) in X-ray and CT Images: A Machine Learning Based Approach.

Biocybern Biomed Eng 2021 Jun 5. Epub 2021 Jun 5.

Department of Computer Science, University of Saskatchewan, Canada.

The newly identified Coronavirus pneumonia, subsequently termed COVID-19, is highly transmittable and pathogenic with no clinically approved antiviral drug or vaccine available for treatment. The most common symptoms of COVID-19 are dry cough, sore throat, and fever. Symptoms can progress to a severe form of pneumonia with critical complications, including septic shock, pulmonary edema, acute respiratory distress syndrome and multi-organ failure. Read More

View Article and Full-Text PDF

The cardiovascular complications in COVID-19: Focus on acute cardiac injury.

Pak J Med Sci 2021 May-Jun;37(3):908-912

Ronak Rajani Cardiothoracic Centre, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom. School of Biomedical Engineering and Imaging Sciences, King's College London, United Kingdom.

At the end of 2019 a novel coronavirus was identified in Wuhan, China. The disease caused by the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) was designated COVID-19 (corona virus disease 2019) by the World Health Organization in early 2020. Up to 80% of patients with COVID-19 experience mild symptoms with severe or critical disease occurring in the remaining 20%. Read More

View Article and Full-Text PDF

Clinical Variants, Characteristics, and Outcomes Among COVID-19 Patients: A Case Series Analysis at a Tertiary Care Hospital in Karachi, Pakistan.

Cureus 2021 Apr 29;13(4):e14761. Epub 2021 Apr 29.

Internal Medicine, OMI Institute, Karachi, PAK.

Introduction Coronavirus disease 2019 (COVID-19) has become a global threat to public health. The current study investigates alterations in the biological estimates concerning the severity, recovery, mortality, and assessment of treatment-based outcomes. Methods A case series of 165 COVID-19 patients admitted to OMI Institute (a tertiary care hospital) was conducted between May and August 2020. Read More

View Article and Full-Text PDF

Assessment of Lung Reaeration at 2 Levels of Positive End-expiratory Pressure in Patients With Early and Late COVID-19-related Acute Respiratory Distress Syndrome.

J Thorac Imaging 2021 Jun 3. Epub 2021 Jun 3.

Departments of Intensive Care Radiology and Nuclear Medicine Respiratory Medicine Anesthesiology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Purpose: Patients with novel coronavirus disease (COVID-19) frequently develop acute respiratory distress syndrome (ARDS) and need invasive ventilation. The potential to reaerate consolidated lung tissue in COVID-19-related ARDS is heavily debated. This study assessed the potential to reaerate lung consolidations in patients with COVID-19-related ARDS under invasive ventilation. Read More

View Article and Full-Text PDF

Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes.

Crit Care Explor 2021 May 12;3(5):e0415. Epub 2021 May 12.

Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objectives: Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.

Design: Retrospective cohort study.

Setting: Northwestern Memorial Hospital ICUs. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.

Heliyon 2021 May 28:e07147. Epub 2021 May 28.

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse 7, 72076, Tübingen, Germany.

The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID19 patients. Read More

View Article and Full-Text PDF

Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach.

Int J Mol Sci 2021 May 24;22(11). Epub 2021 May 24.

Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and devastating clinical disorders with high mortality and no specific therapy. Lipopolysaccharide (LPS) is usually used intratracheally to induce ALI in mice. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (um-PEA) in mice subjected to LPS-induced ALI. Read More

View Article and Full-Text PDF

Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome.

J Clin Med 2021 May 12;10(10). Epub 2021 May 12.

Department of Anaesthesia and Critical Care, DREAM, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France.

The plasma soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury with prognostic value when measured at baseline in acute respiratory distress syndrome (ARDS). However, whether changes in plasma sRAGE could inform prognosis in ARDS remains unknown. In this secondary analysis of the Lung Imaging for Ventilator Setting in ARDS (LIVE) multicenter randomized controlled trial, which evaluated a personalized ventilation strategy tailored to lung morphology, plasma sRAGE was measured upon study entry (baseline) and on days one, two, three, four and six. Read More

View Article and Full-Text PDF

COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?

Rheumatol Int 2021 May 25. Epub 2021 May 25.

Division of Rheumatology, Department of Internal Medicine, Ankara City Hospital, Ankara, 06100, Turkey.

Coronavirus disease 2019 (COVID-19) and eosinophilic granulomatosis with polyangiitis (EGPA) share similarities in clinical, imaging findings and may present with respiratory distress. Differentiating a new-onset EGPA from COVID-19 during the current pandemic is a diagnostic challenge, particularly if other EGPA symptoms are overlooked. Here in this study we reviewed the literature regarding EGPA patients with COVID-19 and patients who diagnosed with EGPA or suffered an EGPA flare mimicking COVID-19. Read More

View Article and Full-Text PDF

Barotrauma Linked to Coronavirus Disease 2019 Infection in Younger Patients: A Case Series.

Cureus 2021 Apr 20;13(4):e14573. Epub 2021 Apr 20.

Pulmonary Critical Care Medicine, Rutgers University, Newark, USA.

Patients infected with coronavirus disease 2019 (COVID-19) on invasive mechanical ventilation were found to have high rates of barotrauma. Herein, we present five patients admitted to the intensive care unit between March and April 2020, who developed barotrauma as a complication of COVID-19 pneumonia. This series includes four males and one female with a mean age of 54 years, most without significant chronic comorbidities or former tobacco use. Read More

View Article and Full-Text PDF

Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and  review of the literature.

J Med Case Rep 2021 May 23;15(1):286. Epub 2021 May 23.

Department of Neurosurgery, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

Background: Choroid plexus carcinoma is an intraventricular neoplasm originating from the choroid plexus epithelium and is of rare occurrence in adults. However, owing to the low prevalence of choroid plexus carcinoma, there is very limited information about the disease entity and treatment. Here we report a rare case of choroid plexus carcinoma in an adult patient. Read More

View Article and Full-Text PDF

Synopsis of Clinical Acute Respiratory Distress Syndrome (ARDS).

Adv Exp Med Biol 2021 ;1304:323-331

Department of Anesthesiology, Albany Medical Center, Albany, NY, USA.

The entity of acute respiratory distress syndrome (ARDS) is an acute inflammatory lung condition associated with lung damage and increased vascular permeability. In the ICU, ARDS was reported to be the cause of 10.4% of admissions. Read More

View Article and Full-Text PDF

Almitrine for COVID-19 critically ill patients - a vascular therapy for a pulmonary vascular disease: Three case reports.

World J Clin Cases 2021 May;9(14):3385-3393

Department of Anaesthesia and Critical Care, Amiens Hospital University, Amiens 80000, France.

Background: Several reports with clinical, histological and imaging data have observed the involvement of lung vascular function to explain the severe hypoxemia in coronavirus disease 2019 (COVID-19) patients. It has been hypothesized that an increased pulmonary blood flow associated with an impairment of hypoxic pulmonary vasoconstriction is responsible for an intrapulmonary shunt. COVID-19 may lead to refractory hypoxemia (PaO/FiO ratio below 100 mmHg) despite mechanical ventilation and prone positioning. Read More

View Article and Full-Text PDF

Dynamic thromboembolic left ventricular outflow tract obstruction after aggressive procoagulant treatment in hemorrhagic shock: a case report.

J Med Case Rep 2021 May 18;15(1):269. Epub 2021 May 18.

Department of Anesthesiology and Intensive Care Medicine (CVK, CCM) Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13357, Berlin, Germany.

Background: In cases of hypertrophic obstructive cardiomyopathy (HOCM), the systolic anterior motion of the mitral valve apparatus results in an obstruction of the left ventricular outflow tract (LVOT), which is known as the SAM [systolic anterior motion] phenomenon. Hypothetically, a pathological obstruction of the LVOT of a different etiology would result in a comparable hemodynamic instability, which would be refractory to inotrope therapy, and may be detectable through echocardiography.

Case Presentation: We observed a severely impaired left ventricular function due to a combination of a thrombotic LVOT obstruction and distinctive mitral regurgitation in a 56-year-old Caucasian, female patient after massive transfusion with aggressive procoagulant therapy. Read More

View Article and Full-Text PDF

Prolonged facemask use in the heat worsens dyspnea without compromising motor-cognitive performance.

Temperature (Austin) 2020 Oct 9;8(2):160-165. Epub 2020 Oct 9.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

Within the context of the COVID-19 pandemic, the WHO endorses facemask use to limit aerosol-spreading of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, concerns have been raised regarding facemask-associated dyspnea, thermal distress and self-reported impairment of cognition. Accordingly, we tested how facemask-use affects motor-cognitive performances of relevance for occupational safety. Read More

View Article and Full-Text PDF
October 2020

Automated detection of acute respiratory distress syndrome from chest X-Rays using Directionality Measure and deep learning features.

Comput Biol Med 2021 May 11;134:104463. Epub 2021 May 11.

Department of Mathematics, Northeastern University, Boston, MA, United States.

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury with global prevalence and high mortality. Chest x-rays (CXR) are critical in the early diagnosis and treatment of ARDS. However, imaging findings may not result in proper identification of ARDS due to a number of reasons, including nonspecific appearance of radiological features, ambiguity in a patient's case due to the pathological stage of the disease, and poor inter-rater reliability from interpretations of CXRs by multiple clinical experts. Read More

View Article and Full-Text PDF

A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.

Physiol Rep 2021 May;9(9):e14871

Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI, USA.

To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a high-fidelity swine model of ARDS utilizing clinically relevant lung injury exposures. Fourteen male swine were anesthetized, mechanically ventilated, and surgically instrumented for hemodynamic monitoring, blood, and tissue sampling. Read More

View Article and Full-Text PDF

Effects of positive end-expiratory pressure on the predictability of fluid responsiveness in acute respiratory distress syndrome patients.

Sci Rep 2021 May 13;11(1):10186. Epub 2021 May 13.

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, 33353, Taiwan.

The prediction accuracy of pulse pressure variation (PPV) for fluid responsiveness was suggested to be unreliable in low tidal volume (VT) ventilation. However, high PEEP can cause ARDS patients relatively hypovolemic and more fluid responsive. We hypothesized that high PEEP 15 cmHO can offset the disadvantage of low VT and improve the predictive performance of PPV. Read More

View Article and Full-Text PDF

A Case of COVID-19 Complicated by Venous Thromboembolism Despite Being on Prophylactic Anticoagulation.

J Med Cases 2020 Jul 18;11(7):189-191. Epub 2020 Jun 18.

Department of Internal Medicine, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.

The coronavirus disease 2019 (COVID-19) presents with variable clinical syndromes, from asymptomatic disease to acute respiratory failure. Complications such as acute respiratory distress syndrome (ARDS), secondary infection, acute cardiac injury, liver failure, renal failure, coagulable disorders and in many cases, death have been recognized. Venous thromboembolism (VTE) was found to be present in up to one-third of critically ill COVID-19 patients. Read More

View Article and Full-Text PDF

Coronavirus disease 2019 (COVID-19)-associated constrictive pericarditis.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Division of Cardiology and Department of Radiology, George Washington University School of Medicine, Washington, DC, USA.

This report documents a rare case of COVID-19-associated constrictive pericarditis (CP) in the setting of a recent COVID-19 infection. A 55-year-old man with a history of hypertension and gout presented with acute hypoxic respiratory failure and was diagnosed with COVID-19 pneumonia with progression to acute respiratory distress syndrome. His hospital course was complicated by a large pericardial effusion; an emergent bedside transthoracic echocardiography was concerning for cardiac tamponade, so pericardiocentesis was performed. Read More

View Article and Full-Text PDF

Treating ARDS-associated air embolism: a question of priorities.

Undersea Hyperb Med 2021 Second Quarter;48(2):169-172

Intensive Care Unit and Hyperbaric Center, Lille University Hospital, Lille, France.

Gas embolism is a potential and often life-threatening complication of central venous catheters. We report a case of air embolism after tearing of the central catheter associated with severe acute respiratory distress syndrome. The severity of the clinical situation meant choices had to be made regarding the order of treatments. Read More

View Article and Full-Text PDF

Disseminated Coccidioidomycosis Presenting as Septic Shock with Multiorgan Failure.

Case Rep Infect Dis 2021 15;2021:8837493. Epub 2021 Apr 15.

Department of Pathology, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, El Paso, TX 79905, USA.

Coccidioidomycosis is a fungal infection caused by and While infections are usually mild, severe disease occurs in immunocompromised patients. Dissemination is associated with severe morbidity and mortality. Because of the tendency of this disease to imitate many diseases, diagnosis may be difficult on presentation. Read More

View Article and Full-Text PDF

A COVID-19 Patient Presenting with Pneumothorax.

Case Rep Infect Dis 2021 14;2021:6652819. Epub 2021 Apr 14.

Department of Pediatric Surgery, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that has affected millions of individuals across the world. It was officially declared as a pandemic on March 11, 2020. Although most patients with COVID-19 manifest as viral pneumonia characterized by symptoms such as fever, dyspnea, and cough, atypical presentations such as acute respiratory distress syndrome (ARDS) and acute kidney or cardiac injury have been reported amongst COVID-19 patients. Read More

View Article and Full-Text PDF

Multidisciplinary corroboration in differentiation syndrome: a case report.

J Med Case Rep 2021 May 5;15(1):226. Epub 2021 May 5.

Department of Pediatric ICU, Tata Medical Center, 14 MAR (E-W), New Town, Rajarhat, Kolkata, 700160, West Bengal, India.

Background: Differentiation syndrome (DS) is a life-threatening complication that may be seen in patients with acute promyelocytic leukaemia undergoing induction therapy with all-trans retinoic acid or arsenic trioxide. It can lead to severe inflammatory response syndrome and shock if adequate measures are not taken immediately. The radiological features of lung nodules with changes in ground-glass opacity can represent DS. Read More

View Article and Full-Text PDF

Correction to: Radiomics score predicts acute respiratory distress syndrome based on the initial CT scan after trauma.

Eur Radiol 2021 May 4. Epub 2021 May 4.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

View Article and Full-Text PDF

Arterial Thrombotic Sequalae After Covid-19: Mind the Gap.

Ann Vasc Surg 2021 May 1. Epub 2021 May 1.

Unit of Vascular and Endovascular Surgery, General Surgery Department, University Hospital of Udine, Udine, Italy.

Investigations have shown that infection from the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is responsible also for initiating severe inflammatory responses that can lead macrovascular and microvascular thrombosis. Several studies have already described acute limb ischemia and peripheral arterial disease in critically ill patients with Coronavirus disease 2019 (Covid-19), as well as coronary artery disease and ischemic stroke as a manifestation usually associated with respiratory distress. However, what still remains unclear is how long inflammation and thrombotic derangements can last after recovery from the symptoms of Covid-19. Read More

View Article and Full-Text PDF

Diminishing Efficacy of Prone Positioning With Late Application in Evolving Lung Injury.

Crit Care Med 2021 Apr 28. Epub 2021 Apr 28.

1 Department of Radiology, University of Pennsylvania, Philadelphia, PA. 2 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA. 3 Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA. 4 Department of Radiology, University of Iowa, Iowa City, IA. 5 Department of Biomedical Engineering, Boston University, Boston, MA. 6 Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA. 7 Department of Physiology, University of Pennsylvania, Philadelphia, PA.

Objectives: It is not known how lung injury progression during mechanical ventilation modifies pulmonary responses to prone positioning. We compared the effects of prone positioning on regional lung aeration in late versus early stages of lung injury.

Design: Prospective, longitudinal imaging study. Read More

View Article and Full-Text PDF

Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease.

Front Neurosci 2021 13;15:667036. Epub 2021 Apr 13.

Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.

Acute respiratory distress syndrome (ARDS) is the most severe form of acute lung injury. It is induced by sepsis, aspiration, and pneumonia, including that caused by SARS coronavirus and human influenza viruses. The main pathophysiological mechanism of ARDS is a systemic inflammatory response. Read More

View Article and Full-Text PDF