2,232 results match your criteria Imaging in Acute Respiratory Distress Syndrome


Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch.

Mol Biol Cell 2019 Feb 13:mbcE18070422. Epub 2019 Feb 13.

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.

Mechanical ventilation remains an imperative treatment for the patients with acute respiratory distress syndrome, but can also exacerbate lung injury. We have previously described a key role of RhoA GTPase in high cyclic stretch (CS)-induced endothelial (EC) barrier dysfunction. However, cellular mechanotransduction complexes remain to be characterized. Read More

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-07-0422
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http://dx.doi.org/10.1091/mbc.E18-07-0422DOI Listing
February 2019
1 Read

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Blood Adv 2019 Feb;3(3):432-445

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar-capillary barrier disruption. However, the mechanisms by which platelets protect the lung alveolar-capillary barrier during infectious injury remain unclear. We found that natively thrombocytopenic mice deficient in the thrombopoietin receptor sustain severe lung injury marked by alveolar barrier disruption and hemorrhagic pneumonia with early mortality following acute intrapulmonary (PA) infection; barrier disruption was attenuated by platelet reconstitution. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018026286DOI Listing
February 2019
2 Reads

Disseminated Blastomycosis in a Teenager Presenting with Pleural Effusion and Splenomegaly.

J Emerg Med 2019 Jan 25. Epub 2019 Jan 25.

Medical College of Wisconsin, Milwaukee, Wisconsin; Children's Hospital of Wisconsin, Milwaukee, Wisconsin.

Background: Blastomycosis is caused by a fungus endemic to states and providences bordering the Lawrence Rivers and the Great Lakes. It can lead to significant pathology in both immunocompetent and immunocompromised hosts. This case report describes disseminated blastomycosis in an otherwise healthy 16-year-old patient. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.035DOI Listing
January 2019
1 Read

Imaging the Injured Lung: Mechanisms of Action and Clinical Use.

Anesthesiology 2019 Jan 17. Epub 2019 Jan 17.

From the Department of Anesthesiology and Critical Care and the Department of Radiology (M.C., Y.X., R.R.R.) University of Pennsylvania, Philadelphia, Pennsylvania; the Interdepartmental Division of Critical Care Medicine and Department of Medicine (A.G.) Hospital for Sick Children (B.P.K., T.Y.), University of Toronto, Toronto, Ontario, Canada the Departments of Anesthesia and Biomedical Engineering (J.H.) and Anesthesia, Radiology, and Biomedical Engineering (D.W.K.), University of Iowa, Iowa City, Iowa the Hedenstierna Laboratory and Uppsala University Hospital, Uppsala University, Uppsala, Sweden (G.P.).

Acute respiratory distress syndrome (ARDS) consists of acute hypoxemic respiratory failure characterized by massive and heterogeneously distributed loss of lung aeration caused by diffuse inflammation and edema present in interstitial and alveolar spaces. It is defined by consensus criteria, which include diffuse infiltrates on chest imaging-either plain radiography or computed tomography. This review will summarize how imaging sciences can inform modern respiratory management of ARDS and continue to increase the understanding of the acutely injured lung. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002583DOI Listing
January 2019
28 Reads
5.879 Impact Factor

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

Departments of1Neurosurgery and.

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18676DOI Listing
January 2019
4 Reads

Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function.

Thorax 2019 Mar 12;74(3):219-228. Epub 2019 Jan 12.

Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: In acute respiratory distress syndrome (ARDS), pulmonary perfusion failure increases physiologic dead space ventilation (V/V), leading to a decline of the alveolar CO concentration [CO]. Although it has been shown that alveolar hypocapnia contributes to formation of atelectasis and surfactant depletion, a typical complication in ARDS, the underlying mechanism has not been elucidated so far.

Methods: In isolated perfused rat lungs, cytosolic or mitochondrial Ca concentrations ([Ca] or [Ca], respectively) of alveolar epithelial cells (AECs), surfactant secretion and the projected area of alveoli were quantified by real-time fluorescence or bright-field imaging (n=3-7 per group). Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211864DOI Listing
March 2019
2 Reads

The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery.

J Cardiothorac Vasc Anesth 2018 Nov 22. Epub 2018 Nov 22.

University Hospitals Birmingham National Health Service Foundation Trust, Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, Centre of Translational Inflammation Research, University of Birmingham, Birmingham, UK.

The right ventricle (RV) has been an area of evolving interest after decades of being ignored and considered less important than the left ventricle. Right ventricular dysfunction/failure is an independent predictor of mortality and morbidity in cardiac surgery; however, very little is known about the incidence or impact of RV dysfunction/failure in thoracic surgery. The pathophysiology of RV dysfunction/failure has been studied in the context of acute respiratory distress syndrome (ARDS), cardiac surgery, pulmonary hypertension, and left ventricular failure, but limited data exist in literature addressing the issue of RV dysfunction/failure in the context of thoracic surgery and one-lung ventilation (OLV). Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.030DOI Listing
November 2018
2 Reads

Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report.

BMC Infect Dis 2018 Dec 27;18(1):693. Epub 2018 Dec 27.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

Background: Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic and therapeutic management.

Case Presentation: A 35-year-old male with a history of fever and back pain. Read More

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http://dx.doi.org/10.1186/s12879-018-3573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307234PMC
December 2018
4 Reads

IL-35 interferes with splenic T cells in a clinical and experimental model of acute respiratory distress syndrome.

Int Immunopharmacol 2019 Feb 22;67:386-395. Epub 2018 Dec 22.

The Laboratory of Lipid & Glucose Metabolism, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Emergency and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome with uncontrolled inflammation that is a central issue. Its main characteristic is inflammatory mediators and cytokines as well as agglutinating chemokines that injure target cells. Interleukin (IL)-35 is a newly identified IL-12 cytokine family member with structural similarities to other IL-12, IL-23, and IL-27 cytokines but unique immunological functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183133
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http://dx.doi.org/10.1016/j.intimp.2018.12.024DOI Listing
February 2019
3 Reads

Undiagnosed hypertrophic obstructive cardiomyopathy during transcatheter aortic valve replacement: a case report.

J Med Case Rep 2018 Dec 18;12(1):372. Epub 2018 Dec 18.

Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA.

Background: Transcatheter aortic valve replacement is indicated for severe symptomatic aortic stenosis in patients who have a very high or prohibitive surgical risk as assessed pre-procedurally by the Society of Thoracic Surgery Risk Score, EuroSCORE (II), frailty testing, and other predictors. When combined with another left ventricular outflow tract obstruction, careful consideration must be taken prior to proceeding with transcatheter aortic valve replacement because an additional masked left ventricular outflow tract pathology can lead to challenging hemodynamics in the peri-deployment phase, as reported in this case.

Case Presentation: A 56-year-old Caucasian man with multiple comorbidities and severe aortic stenosis underwent transcatheter aortic valve replacement under monitored anesthesia care. Read More

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http://dx.doi.org/10.1186/s13256-018-1904-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298014PMC
December 2018
2 Reads

Rare respiratory diseases in the ICU: when to suspect them and specific approaches.

Curr Opin Crit Care 2019 Feb;25(1):29-36

Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de Recherche Clinique CARMAS, Créteil.

Purpose Of Review: A prompt identification of the cause of acute respiratory failure (ARF)/acute respiratory distress syndrome (ARDS) is required in order to initiate a targeted treatment. Yet, almost 10% of ARDS patients have no identified ARDS risk factor at ARDS diagnosis. Numerous rare causes of ARF have been reported in this setting. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000572DOI Listing
February 2019
8 Reads

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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https://actavetscand.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13028-018-0433-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282261PMC
December 2018
12 Reads

Intravascular large B-cell lymphoma presenting with diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding CT abnormality.

Radiol Case Rep 2019 Feb 23;14(2):260-264. Epub 2018 Nov 23.

Department of Radiology, Kansas University Hospital, 3901 Rainbow Blvd, MS 4032, Kansas City, KS, USA.

A 60-year-old male presented with complaints of dyspnea, intermittent fever, and 40 pounds of weight loss over the previous 9 months and was admitted for acute hypoxemic respiratory failure. Labs demonstrated elevated inflammatory markers, mild anemia, and thrombocytopenia. Fluorodeoxyglucose-positron emission tomography scan demonstrated diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding abnormality on CT images. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183045
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http://dx.doi.org/10.1016/j.radcr.2018.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260434PMC
February 2019
8 Reads

Acute respiratory distress syndrome after the use of gadolinium contrast agent.

Respir Med Case Rep 2018 24;25:336-338. Epub 2018 Oct 24.

Department of Pulmonary Diseases, Ataturk University, School of Medicine, 25240, Erzurum, Turkey.

Acute respiratory distress syndrome (ARDS) is a life-threatening medical emergency. The etiology of ARDS can involve various causes. ARDS associated with the use of iodinated contrast media is rarely reported, and the literature includes only one case of ARDS due to gadobutrol. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183008
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http://dx.doi.org/10.1016/j.rmcr.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223103PMC
October 2018
13 Reads

Post esophagectomy diaphragmatic hernia: a case report of a rare cause of acute respiratory distress.

J Cardiothorac Surg 2018 Nov 15;13(1):114. Epub 2018 Nov 15.

Service of Cardiac Surgery, Multidisciplinary Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, QC, Canada.

Background: Diaphragmatic hernia is frequent among the elderly and is usually associated with mild chronic digestive and respiratory symptoms.

Case Presentation: An elderly post-esophagectomy male patient, in the early postoperative period of cardiac surgery, presented with acute respiratory distress. An emergent surgery was performed to reduce a giant diaphragmatic herniation. Read More

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http://dx.doi.org/10.1186/s13019-018-0802-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238405PMC
November 2018

An unusual presentation of gall bladder papillomatosis in association with metachromatic leukodystrophy.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Department of Paediatric Surgery, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 5-year-old boy with metachromatic leukodystrophy, debilitated by spastic quadriparesis presented to us with massive ascites and respiratory distress. A subtotal cholecystectomy was performed on him from another centre for a gall bladder mass a year before he came to us. Imaging revealed a polypoidal frond-like mass arising from the gall bladder fossa which was supplied by a hypertrophied branch of the right hepatic artery. Read More

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http://dx.doi.org/10.1136/bcr-2017-224162DOI Listing
November 2018
2 Reads

Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study.

Lancet Respir Med 2019 Feb 22;7(2):115-128. Epub 2018 Oct 22.

Penn State Hershey Children's Hospital, Penn State University School of Medicine, Hershey, PA, USA.

Background: Paediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183034
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http://dx.doi.org/10.1016/S2213-2600(18)30344-8DOI Listing
February 2019
15 Reads

Electrical impedance tomography in acute respiratory distress syndrome.

Crit Care 2018 10 25;22(1):263. Epub 2018 Oct 25.

Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currently, computed tomography (CT) is commonly used for classifying and prognosticating ARDS. However, performing this examination in critically ill patients is complex, due to the need to transfer these patients to the CT room. Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2195-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203288PMC
October 2018
7 Reads

Two Medullary Hemorrhage Cases Complicated by Respiratory Distress in the Early Phase.

J Stroke Cerebrovasc Dis 2019 Jan 15;28(1):229-231. Epub 2018 Oct 15.

Department of Neurology, Tokyo Saiseikai Central Hospital, Tokyo, Japan. Electronic address:

Medullary hemorrhage is quite rare among brain stem hemorrhage cases, thus the clinical course remains unclear. In the medulla oblongata, respiratory centers are located and previous reports indicate that medullary lesions have possible relationship with acute respiratory distress syndrome. This kind of respiratory failure is commonly caused by neurogenic pulmonary edema (NPE), which is defined as noncardiac noninfectious acute respiratory distress syndrome with changes in intracranial condition including cerebrovascular events. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.027DOI Listing
January 2019
2 Reads

Clinical implication of radiographic scores in acute Middle East respiratory syndrome coronavirus pneumonia: Report from a single tertiary-referral center of South Korea.

Eur J Radiol 2018 Oct 11;107:196-202. Epub 2018 Sep 11.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

The aim of this study is to determine the earliest cutoff of radiographic score as a potential prognostic indicator of fatal outcomes in patients with acute Middle East respiratory syndrome coronavirus (MERS-CoV) pneumonia. The institutional review board approved this retrospective study. Serial chest radiographies (CXRs) were obtained from viral exposure until death or discharge in 35 patients with laboratory confirmed MERS-CoV infection. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.09.008DOI Listing
October 2018
1 Read
2.370 Impact Factor

Massive gastric dilatation leading to acute respiratory distress 1 year after a Nissen fundoplication.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Surgery, BHR Hospitals Trust, Romford, UK.

Acute massive gastric dilatation (AMGD) is a recognised complication after Nissen fundoplication. A 63-year-old man recently presented to our emergency department in acute respiratory distress, acute abdominal pain and distension, having had an elective umbilical port incisional hernia repair a day prior. In the year preceding his presentation, the patient had undergone a laparoscopic paraoesophageal hiatus hernia repair and excision of sac, posterior cruropexy, dual mesh reinforcement of repair and 360° fundoplication, as a day case. Read More

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http://dx.doi.org/10.1136/bcr-2018-225927DOI Listing
September 2018
3 Reads

Ventilator-Associated Pneumonia and Events in Pediatric Intensive Care: A Single Center Study.

Pediatr Crit Care Med 2018 Dec;19(12):1106-1113

Pediatric Intensive Care Unit, Sainte-Justine University Hospital Center, Montreal, QC, Canada.

Objectives: Ventilator-associated pneumonia is the second most common nosocomial infection in pediatric intensive care. The Centers for Disease Control and Prevention recently issued diagnosis criteria for pediatric ventilator-associated pneumonia and for ventilator-associated events in adults. The objectives of this pediatric study were to determine the prevalence of ventilator-associated pneumonia using these new Centers for Disease Control and Prevention criteria, to describe the risk factors and management of ventilator-associated pneumonia, and to assess a simpler method to detect ventilator-associated pneumonia with ventilator-associated event in critically ill children. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001720DOI Listing
December 2018
3 Reads

Pulmonary Glue Embolism: An unusual complication following endoscopic sclerotherapy for gastric varices.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e231-e235. Epub 2018 Sep 9.

Department of Radiology, Hull Royal Infirmary, Hull, UK.

A pulmonary glue embolism is an unusual but potentially life-threatening complication following the treatment of variceal bleeding, especially in patients with large varices requiring large volumes of sclerosant. Other contributory factors include the rate of injection and ratio of the constituent components of the sclerosant (i.e. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132531PMC
May 2018
2 Reads

Radiologic and autopsy findings in a case of fatal immune checkpoint inhibitor-associated pneumonitis.

Cancer Treat Res Commun 2018 21;15:17-20. Epub 2018 Feb 21.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

Oncologists are increasingly managing drug-induced pneumonitis in lung cancer patients treated with PD-1/PD-L1 immune checkpoint inhibitors. To date only few studies on the topic have described both radiologic and pathologic findings in these patients. Here, we report a fatal case of immune checkpoint inhibitor-associated pneumonitis initially presenting with an organizing pneumonia, but who rapidly developed acute respiratory distress syndrome (confirmed histologically at the time of autopsy). Read More

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http://dx.doi.org/10.1016/j.ctarc.2018.02.004DOI Listing
February 2018
8 Reads

A Case of Acute Respiratory Distress Syndrome Caused by Waterproofing Spray Inhalation.

Tokai J Exp Clin Med 2018 Sep 20;43(3):106-110. Epub 2018 Sep 20.

Department of Emergency and Critical Care Medicine, Odawara Municipal Hospital, 46 Kuno, Odawara, Kanagawa 250-8558, Japan.

We report the case of a 62-year-old man who used approximately one can of waterproofing spray in an enclosed room and, then, smoked a cigarette. He developed a fever of 39°C with respiratory distress and was transported by ambulance to his usual doctor. Since his respiratory state was very severe, he was transferred to our hospital. Read More

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September 2018
22 Reads

Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells.

Inflammation 2018 Sep 5. Epub 2018 Sep 5.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been shown to improve ALI, and the imbalance of regulatory T cells (Tregs) and Th17 cells is associated with mortality in ALI/ARDS patients. However, whether administration of lung-resident MSC (LRMSC) improves lung injury and regulates the balance of Tregs and Th17 cells remains unknown. Read More

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http://dx.doi.org/10.1007/s10753-018-0884-6DOI Listing
September 2018
1 Read

Adjuvant lung resection in the management of nontuberculous mycobacterial lung infection: A retrospective matched cohort study.

Respir Med 2018 09 9;142:1-6. Epub 2018 Jul 9.

Division of Respirology, Department of Medicine, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Medicine, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada. Electronic address:

Background And Objectives: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is considered when medical therapy alone fails to provide long term control. Data regarding comparative and long-term outcomes are limited. We aimed to review indications and outcomes of adjuvant lung resection for NTM-PD compared with controls. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.07.003DOI Listing
September 2018
3 Reads

Chest radiography versus lung ultrasound for identification of acute respiratory distress syndrome: a retrospective observational study.

Crit Care 2018 08 18;22(1):203. Epub 2018 Aug 18.

Division of Critical Care-Respiratory Therapy, National University Hospital, Singapore, Singapore.

Background: Lung ultrasound may be a reasonable alternative to chest radiography for the identification of acute respiratory distress syndrome (ARDS), but the diagnostic performance of lung ultrasound for ARDS is uncertain. We therefore analyzed the clinical outcomes of ARDS diagnosed according to the Berlin Definition, using either chest radiography (Berlin-CXR) or lung ultrasound (Berlin-LUS) as an alternative imaging method.

Methods: This was a retrospective observational study in a 20-bed medical intensive care unit (ICU). Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098581PMC
August 2018
8 Reads

Diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome.

BMC Pulm Med 2018 Aug 13;18(1):136. Epub 2018 Aug 13.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Background: Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome (ARDS) is still unclear.

Methods: Consecutive patients admitted to ICU with the diagnosis of suspected ARDS based on clinical grounds were enrolled. Read More

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http://dx.doi.org/10.1186/s12890-018-0666-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090678PMC
August 2018
6 Reads

Distribution of alveolar-interstitial syndrome in dogs and cats with respiratory distress as assessed by lung ultrasound versus thoracic radiographs.

J Vet Emerg Crit Care (San Antonio) 2018 Sep 3;28(5):415-428. Epub 2018 Aug 3.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

Objective: To assess distribution of alveolar-interstitial syndrome (AIS) detected by lung ultrasound (LUS) compared to thoracic radiographs (TXR).

Design: Prospective study.

Setting: University teaching hospital. Read More

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http://dx.doi.org/10.1111/vec.12750DOI Listing
September 2018
2 Reads

Blast from the past: a novel complication of bronchopulmonary dysplasia.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Pulmonology/Critical Care, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1136/bcr-2018-225005DOI Listing
July 2018
2 Reads

Salvage therapies for refractory hypoxemia in ARDS.

Respir Med 2018 08 3;141:150-158. Epub 2018 Jul 3.

Pulmonary, Critical Care and Sleep Medicine, U C San Diego School of Medicine, USA. Electronic address:

Acute Respiratory Distress Syndrome (ARDS) is a condition of varied etiology characterized by the acute onset (within 1 week of the inciting event) of hypoxemia, reduced lung compliance, diffuse lung inflammation and bilateral opacities on chest imaging attributable to noncardiogenic (increased permeability) pulmonary edema. Although multi-organ failure is the most common cause of death in ARDS, an estimated 10-15% of the deaths in ARDS are caused due to refractory hypoxemia, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183022
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http://dx.doi.org/10.1016/j.rmed.2018.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186150PMC
August 2018
20 Reads

Radiolabelled leucocytes in human pulmonary disease.

Br Med Bull 2018 Sep;127(1):69-82

Department of Nuclear Medicine, Brighton and Sussex Medical School, Brighton, East Sussex, UK.

Introduction: Radionuclides for leucocyte kinetic studies have progressed from non-gamma emitting cell-labelling radionuclides through gamma emitting nuclides that allow imaging of leucocyte kinetics, to the next goal of positron emission tomography (PET).

Sources Of Data: Mostly the authors' own studies, following on from studies of the early pioneers.

Areas Of Controversy: From early imaging studies, it appeared that the majority of the marginated granulocyte pool was located in the lungs. Read More

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http://dx.doi.org/10.1093/bmb/ldy022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312042PMC
September 2018
4 Reads

Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation, and Therapeutic Implications.

Front Immunol 2018 9;9:1545. Epub 2018 Jul 9.

Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Acute respiratory distress syndrome/acute lung injury (ALI) was described in 1967. The uncontrolled inflammation is a central issue of the syndrome. The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046379PMC
July 2018
6 Reads

Etoposide and Corticosteroid Combination Therapy Improves Acute Respiratory Distress Syndrome in Mice.

Shock 2018 Jul 19. Epub 2018 Jul 19.

Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Excessive inflammation reactions with a cytokine storm in the lungs have historically been thought as the primary cause of fatal acute respiratory distress syndrome (ARDS). However, interruption of inflammatory cytokine activation failed to attenuate ARDS, suggesting that other therapies are required to treat this illness and improve survival. Etoposide (ET), a cytotoxic agent, and prednisolone (PSL), a corticosteroid with strong anti-inflammatory activity, have been used to treat other disease involving similar cytokine-activated macrophages and hemophagocytic activity. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001231DOI Listing
July 2018
4 Reads

[Analysis of 15 cases of avian influenza virus (H7N9) infection].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Jul;41(7):534-538

Taizhou People's Hospital, Taizhou 225300, China.

To describe the clinical, chest imaging, pathological manifestations and therapeutic experience of human infection with A/H7N9 virus. The features of 15 laboratory-confirmed cases of human infection with A/H7N9 virus in Taizhou, Jiangsu Province were retrospectively analyzed. The 15 patients with confirmed viral pneumonia included 12 males and 3 females, with a median age of 61 years(ranging from 33 to 81 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.07.006DOI Listing
July 2018
16 Reads

Severe acute respiratory distress syndrome in a liver transplant patient.

Med Mycol Case Rep 2018 Sep 6;21:1-3. Epub 2018 Mar 6.

Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.

This case report presents a 46-year old man with a failed liver transplant who presented with malaise and dyspnea. Imaging studies revealed diffuse reticulonodular infiltrates and innumerable miliary nodules and a left upper lobe consolidative mass. Examination of bronchoalveolar lavage fluid demonstrated yeast cells with broad-based budding. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026297PMC
September 2018
2 Reads

Cerebral microbleeds and intracerebral hemorrhage associated with veno-venous extracorporeal membrane oxygenation.

Acta Neurol Belg 2018 Sep 6;118(3):513-515. Epub 2018 Jul 6.

Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13760-018-0975-zDOI Listing
September 2018
11 Reads

Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair.

Am J Respir Cell Mol Biol 2018 Nov;59(5):635-647

1 Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.

Studies showed that TRIM72 is essential for repair of alveolar cell membrane disruptions, and exogenous recombinant human TRIM72 protein (rhT72) demonstrated tissue-mending properties in animal models of tissue injury. Here we examine the mechanisms of rhT72-mediated lung cell protection in vitro and test the efficacy of inhaled rhT72 in reducing tissue pathology in a mouse model of ventilator-induced lung injury. In vitro lung cell injury was induced by glass beads and stretching. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2017-0364OC
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http://dx.doi.org/10.1165/rcmb.2017-0364OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236686PMC
November 2018
36 Reads
3.985 Impact Factor

Splenic rupture from babesiosis, an emerging concern? A systematic review of current literature.

Ticks Tick Borne Dis 2018 09 12;9(6):1377-1382. Epub 2018 Jun 12.

Department of Radiology, Yale New Haven Health Bridgeport Hospital, 267 Grant Street, Bridgeport, CT, 06610, United States. Electronic address:

Babesiosis is a relatively common tick-borne parasitic infection of erythrocytes primarily affecting the northeastern United States. Babesiosis' prevalence and presentation have earned it the monikers "malaria of the northeast" and "Nantucket fever". Clinical presentation ranges from asymptomatic infection to severe infection including acute respiratory distress syndrome (ARDS) and disseminated intravascular coagulopathy (DIC) or death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173033
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http://dx.doi.org/10.1016/j.ttbdis.2018.06.004DOI Listing
September 2018
17 Reads
2.720 Impact Factor

An Unusual Cause of Cauda Equina Syndrome: Lumbar Epidural Venous Engorgement.

Am J Case Rep 2018 Jun 15;19:694-698. Epub 2018 Jun 15.

Department of Neuroradiology, King Fahad Medical City, Riyadh, Saudi Arabia.

BACKGROUND Epidural venous plexus (EVP) engorgement occurs due to many conditions, so it can be easily misdiagnosed. This becomes problematic when the diagnosis requires prompt treatment for a good outcome, especially when it results in cauda equina syndrome (CES). We report a case of extensive iliocaval thrombosis leading to epidural venous plexus and ascending lumbar vein engorgement as an outcome of deep venous thrombosis (DVT) due to probable adverse effects of oral combined contraceptive pills (OCCP). Read More

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https://www.amjcaserep.com/abstract/index/idArt/908793
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http://dx.doi.org/10.12659/AJCR.908793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034556PMC
June 2018
7 Reads

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.

Thorax 2018 09 14;73(9):840-846. Epub 2018 Jun 14.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Background: There is no accurate, non-invasive measurement to estimate the degree of pulmonary oedema in acute respiratory distress syndrome (ARDS). We developed the Radiographic Assessment of Lung Oedema (RALE) score to evaluate the extent and density of alveolar opacities on chest radiographs. After first comparing the RALE score to gravimetric assessment of pulmonary oedema in organ donors, we then evaluated the RALE score in patients with ARDS for its relationship to oxygenation and clinical outcomes. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2017-211280DOI Listing
September 2018
14 Reads

Primary cardiac angiosarcoma: a rare cause of diffuse alveolar haemorrhage.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Internal Medicine, Northwell Health, Great Neck, New York, USA.

Primary cardiac angiosarcoma is a rare disease with a dismal prognosis. We report a case of a 50-year-old man who presented with haemoptysis, cough and worsening dyspnoea. An intracardiac mass was visualised on echocardiogram. Read More

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http://dx.doi.org/10.1136/bcr-2018-225365DOI Listing
June 2018
4 Reads

A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult.

Case Rep Infect Dis 2018 15;2018:6796839. Epub 2018 Apr 15.

4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Human coronavirus 229E (HCoV-229E) is one of the first coronavirus strains being described. It is linked to common cold symptoms in healthy adults. Younger children and the elderly are considered vulnerable to developing lower respiratory tract infections (LRTIs). Read More

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http://dx.doi.org/10.1155/2018/6796839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925015PMC
April 2018
3 Reads

Hopkins syndrome following the first episode of bronchial asthma associated with enterovirus D68: a case report.

BMC Neurol 2018 May 23;18(1):71. Epub 2018 May 23.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Hopkins syndrome (HS) is a rare disorder presenting with acute flaccid paralysis of the limbs following an asthma attack. Neurologists encounter a diagnostic challenge if patients without a history of bronchial asthma develop neurologic features mimicking HS following acute respiratory distress. We report a case of HS occurring after a first episode of bronchial asthma associated with enterovirus D68 infection. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966892PMC
May 2018
8 Reads

Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.

Am J Respir Crit Care Med 2018 Oct;198(7):891-902

1 Department of Anesthesia, Critical Care and Pain Medicine.

Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown.

Objectives: To test the hypotheses that a strategy consistent with clinical practice does not protect from worsening in lung strains during the first 24 hours of ventilation of initially normal lungs exposed to mild systemic endotoxemia in supine versus prone position, and that local neutrophilic inflammation is associated with local strain and blood volume at global strains below a proposed injurious threshold.

Methods: Voxel-level aeration and tidal strain were assessed by computed tomography in sheep ventilated with low Vt and positive end-expiratory pressure while receiving intravenous endotoxin. Read More

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http://dx.doi.org/10.1164/rccm.201710-2038OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173064PMC
October 2018
6 Reads

Nasogastric Tube Syndrome: A Diagnostic Dilemma.

J Bronchology Interv Pulmonol 2018 Oct;25(4):343-345

Pediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Nasogastric tubes have been used in the pediatric age group to supplement nutrition in cases of malignancy and failure to thrive due to a variety of causes. Breathing difficulty may occur after the insertion of a nasogastric tube and it can have multiple causes. Here we discuss 2 patients of acute lymphoblastic leukemia (ALL) who developed a rare condition called the Sofferman syndrome (nasogastric tube syndrome). Read More

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http://dx.doi.org/10.1097/LBR.0000000000000507DOI Listing
October 2018
2 Reads

Pneumoperitoneum in a neonate weighing less than 500 g. What do we really know about it?

BMJ Case Rep 2018 May 16;2018. Epub 2018 May 16.

Neonatal Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.

Pneumoperitoneum in preterm infants is a surgical emergency as it is usually indicative of intestinal perforation. Rare cases of idiopathic pneumoperitoneum have been described in the literature, the underlying causes and pathophysiology of which remain uncertain. We present a case of pneumoperitoneum in an extremely preterm infant with severe growth restriction. Read More

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http://dx.doi.org/10.1136/bcr-2018-224398DOI Listing
May 2018
4 Reads

Lung Ultrasonography for Assessing Lung Aeration in Acute Respiratory Distress Syndrome: A Narrative Review.

J Ultrasound Med 2019 Jan 6;38(1):27-37. Epub 2018 May 6.

Ecodiagnóstico-Centro de Diagnóstico por Imágenes, Necochea, Argentina.

Acute respiratory distress syndrome (ARDS) constitutes a high burden for intensive care units. Although several methods are proposed to monitor aeration in ARDS, availability, costs, simplicity, and hazards (eg, ionizing radiation) limit the use of many of them at patients' bedsides. Given the widespread use of lung ultrasonography (US) in intensive care units, research is growing regarding its use to monitor aeration in patients with ARDS. Read More

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http://dx.doi.org/10.1002/jum.14671DOI Listing
January 2019
1 Read

Superior mesenteric artery stenting using embolic protection device for treatment of acute or chronic mesenteric ischemia.

J Vasc Surg 2018 10 21;68(4):1071-1078. Epub 2018 Apr 21.

Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn.

Objective: The objective of the study was to report the feasibility and results of superior mesenteric artery (SMA) stenting using embolic protection devices (EPDs) to treat acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI).

Methods: A retrospective review was conducted of consecutive patients who underwent SMA stenting with EPDs from 2007 to 2016. EPDs were used selectively in patients with occlusions, severe calcification, or acute thrombus. Read More

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http://dx.doi.org/10.1016/j.jvs.2017.12.076DOI Listing
October 2018
6 Reads