577 results match your criteria Imaging Pulmonary Interstitial Emphysema


Diagnostic Accuracy of Multidetector CT in Detection of Early Interstitial Lung Disease With Its Role in Characterization.

Cureus 2020 May 23;12(5):e8253. Epub 2020 May 23.

Radiodiagnosis, Era's Lucknow Medical College and Hospital, Lucknow, IND.

Background Multidetector CT (MDCT) has emerged as a useful option for early diagnosis of interstitial lung disease (ILD) with adequate accuracy. Methods A total of 80 patients with restricted pulmonary functions and clinical suspicion of ILD were enrolled in the study. MDCT evaluation was done using Siemens Somatom Force 384 slice multidetector computer tomography machine. Read More

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http://dx.doi.org/10.7759/cureus.8253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308819PMC

Pitfalls of Computed Tomography in the Coronavirus 2019 (COVID-19) Era: A New Perspective on Ground-Glass Opacities.

Cureus 2020 May 16;12(5):e8151. Epub 2020 May 16.

Radiology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, ITA.

Aim To study ground-glass opacities (GGO) not only from the coronavirus 2019 (COVID-19) pneumonia" perspective but also as a radiological presentation of other pathologies with comparable features. Methods We enrolled 33 patients admitted to Policlinico Universitario G. B. Read More

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http://dx.doi.org/10.7759/cureus.8151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294903PMC

A SR-NET 3D-TO-2D ARCHITECTURE FOR PARASEPTAL EMPHYSEMA SEGMENTATION.

Proc IEEE Int Symp Biomed Imaging 2019 Apr 11;2019:303-306. Epub 2019 Jul 11.

Applied Chest Imaging Laboratory, Brigham and Womens Hospital, Boston, MA, USA.

Paraseptal emphysema (PSE) is a relatively unexplored emphysema subtype that is usually asymptomatic, but recently associated with interstitial lung abnormalities which are related with clinical outcomes, including mortality. Previous local-based methods for emphysema subtype quantification do not properly characterize PSE. This is in part for their inability to properly capture the global aspect of the disease, as some the PSE lesions can involved large regions along the chest wall. Read More

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http://dx.doi.org/10.1109/isbi.2019.8759184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251982PMC

Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study.

Medicine (Baltimore) 2020 May;99(20):e19948

Department of Radiology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

There are limited systematic studies on hematologic disease complicated by air leak syndrome (ALS). Physicians in radiology departments and hematology departments have a limited awareness of ALS.The aim of this study was to explore the similarities and differences in clinical data between the clinical group and imaging group in patients with hematologic disease complicated by ALS. Read More

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http://dx.doi.org/10.1097/MD.0000000000019948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254183PMC

Risk prediction model in rheumatoid arthritis-associated interstitial lung disease.

Respirology 2020 May 22. Epub 2020 May 22.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background And Objective: RA-ILD has a variable clinical course, and its prognosis is difficult to predict. Moreover, risk prediction models for prognosis remain undefined.

Methods: The prediction model was developed using retrospective data from 153 patients with RA-ILD and validated in an independent RA-ILD cohort (n = 149). Read More

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http://dx.doi.org/10.1111/resp.13848DOI Listing
May 2020
3.495 Impact Factor

[CT manifestations and prognosis of acute paraquat induced lung injury].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Feb;38(2):140-144

Occupational Poisoning Department of Xuzhou Tumor Hospital. Xuzhou 221005, China.

To investigate the CT features of lung injury induced by paraquat poisoning and its relationship with prognosis, and to provide reference for the judgment of the condition and prognosis of paraquat poisoning. 146 cases of paraquat poisoning patients were treated in the Third People's Hospital of Xuzhou City from January 2013 to April 2016. The cases were divided into mild group, moderate-severe group and fulminant group according to the concentration of paraquat in urine. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2020.02.014DOI Listing
February 2020

[Research progress on early identification of severe adenovirus pneumonia in children].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2019 Jul;48(5):567-572

The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

Severe adenovirus pneumonia has a high mortality and incidence of sequelae. Fever and cough are the main symptoms of children's severe adenovirus pneumonia, but such clinical manifestations are lack of specificity. For children with persistent high fever who are in the epidemic age and season, the adenovirus etiology detection, blood routine, cytokines, T cell subsets and imaging examinations are suggested. Read More

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Detection of secondary causes of spontaneous pneumothorax: Comparison between computed tomography and chest X-ray.

Diagn Interv Imaging 2020 Apr 18;101(4):217-224. Epub 2019 Dec 18.

Department of Respiratory Medicine, AP-HP, hôpital Tenon, 75020 Paris, France; Thoracic Surgery Department, AP-HP, hôpital Tenon, 75020 Paris, France; Thoracic Oncology Department, Paris-Diderot University, AP-HP, hôpital Bichat, 75018 Paris, France. Electronic address:

Purpose: The aim of this study was to compare the effectiveness of chest X-ray to that of thoracic computed tomography (CT) for the detection of the causes of secondary spontaneous pneumothorax (SP).

Methods: A prospective cohort of patients with SP was studied. All chest X-ray and CT examinations of the patients were reviewed retrospectively by an expert radiologist blinded to clinical data. Read More

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http://dx.doi.org/10.1016/j.diii.2019.11.002DOI Listing

Quantitative CT Analysis of Diffuse Lung Disease.

Radiographics 2020 Jan-Feb;40(1):28-43. Epub 2019 Nov 29.

From the Department of Radiology (A.C., B.J.B., C.W.K.) and Biomedical Medicine Imaging Resource (R.A.K.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

Quantitative analysis of thin-section CT of the chest has a growing role in the clinical evaluation and management of diffuse lung diseases. This heterogeneous group includes diseases with markedly different prognoses and treatment options. Quantitative tools can assist in both accurate diagnosis and longitudinal management by improving characterization and quantification of disease and increasing the reproducibility of disease severity assessment. Read More

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http://dx.doi.org/10.1148/rg.2020190099DOI Listing
November 2019

Characteristics of tobacco-related lung diseases in Fukuoka Prefecture, Japan: A prospective, multi-institutional, observational study.

Respir Investig 2020 Jan 11;58(1):74-80. Epub 2019 Nov 11.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

Background: Tobacco smoking causes a variety of smoking-related diseases, death, and economic damage. Despite targeted anti-smoking campaigns, tobacco-related deaths are expected to increase in Japan. We investigated the current state of non-cancerous lung diseases such as idiopathic interstitial pneumonias (IIPs), chronic obstructive pulmonary disease (COPD), and combined pulmonary fibrosis and emphysema (CPFE), which are known to be highly related to tobacco smoking. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.10.002DOI Listing
January 2020

Diffuse alveolar haemorrhage associated with subsequent development of ANCA positivity and emphysema in three young adults.

BMC Pulm Med 2019 Oct 24;19(1):185. Epub 2019 Oct 24.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Background: Diffuse alveolar haemorrhage (DAH) is characterized by the diffuse accumulation of red blood cells within the alveoli, presence of ground glass opacities and/or consolidation on computed tomography (CT). Aside from identifiable non-immune causes, DAH is classically subdivided into idiopathic (idiopathic pulmonary haemosiderosis, IPH) and autoimmune DAH. Here we describe three cases presenting with recurrent pulmonary haemorrhage, initially classified as IPH, who, several years after first presentation, develop anti myeloperoxidase antibodies (MPO) positivity, emphysema on CT and, in one case, renal involvement. Read More

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http://dx.doi.org/10.1186/s12890-019-0947-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813980PMC
October 2019
2.489 Impact Factor

Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema.

Eur Respir J 2020 Jan 30;55(1). Epub 2020 Jan 30.

Pulmonary Vascular Disease and Interstitial Lung Disease Services, Division of Respirology, Federal University of Sao Paulo, Sao Paulo, Brazil.

The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxaemia. However, there is little evidence to support these assumptions.We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients matched by the severity of exertional hypoxaemia. Read More

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http://dx.doi.org/10.1183/13993003.01319-2019DOI Listing
January 2020

Case 28-2019: A 22-Year-Old Woman with Dyspnea and Chest Pain.

N Engl J Med 2019 09;381(11):1059-1067

From the Department of Pediatrics, UMass Memorial Medical Center, and the Department of Pediatrics, University of Massachusetts Medical School, Worcester (T.M.K.), the Departments of Pediatrics (M.E.L., T.B.K.), Radiology (B.P.L.), and Pathology (M.M.-K.), Massachusetts General Hospital, and the Departments of Pediatrics (M.E.L., T.B.K.), Radiology (B.P.L.), and Pathology (M.M.-K.), Harvard Medical School, Boston, and the Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge (M.H.H.) - all in Massachusetts.

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http://dx.doi.org/10.1056/NEJMcpc1904041DOI Listing
September 2019
4 Reads

A Stepwise Diagnostic Approach to Cystic Lung Diseases for Radiologists.

Korean J Radiol 2019 09;20(9):1368-1380

Department of Radiology, Korea University Anam Hospital, College of Medicine, Korea University, Seoul, Korea.

Lung cysts are commonly seen on computed tomography (CT), and cystic lung diseases show a wide disease spectrum. Thus, correct diagnosis of cystic lung diseases is a challenge for radiologists. As the first diagnostic step, cysts should be distinguished from cavities, bullae, pneumatocele, emphysema, honeycombing, and cystic bronchiectasis. Read More

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http://dx.doi.org/10.3348/kjr.2019.0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715565PMC
September 2019
5 Reads

Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population.

Int J Chron Obstruct Pulmon Dis 2019 24;14:1657-1668. Epub 2019 Jul 24.

Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to describe the normal range of lung attenuation distribution and lung volume based on CT. Subjects with normal lung function and basically normal chest CT findings (derivation group) at Ruijin Hospital, Shanghai (from January 2010 to June 2014) were included according to inclusion and exclusion criteria. Read More

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http://dx.doi.org/10.2147/COPD.S187596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662163PMC
February 2020
2 Reads

Neurofibromatosis type-1-associated diffuse lung disease in children.

Pediatr Pulmonol 2019 11 13;54(11):1760-1764. Epub 2019 Aug 13.

Department of Imaging, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Objective: The purpose of the study was to investigate the occurrence of diffuse lung disease associated with neurofibromatosis type-1 in the pediatric population. We also aimed at evaluating computed tomography (CT) findings of the disease.

Introduction: Diffuse lung disease associated with neurofibromatosis type-1 has been described mainly in the adult population; causes and connections between lung disease and the genetic disorder are still not completely understood. Read More

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http://dx.doi.org/10.1002/ppul.24481DOI Listing
November 2019
5 Reads

Using Quantitative Computed Tomographic Imaging to Understand Chronic Obstructive Pulmonary Disease and Fibrotic Interstitial Lung Disease: State of the Art and Future Directions.

J Thorac Imaging 2020 Jul;35(4):246-254

Centre for Heart Lung Innovation, St. Paul's Hospital.

Computed tomography (CT) is commonly used in the evaluation and management of patients with diffuse lung pathologies, including chronic obstructive pulmonary disease (COPD) and fibrotic interstitial lung disease (ILD). In clinical practice, the qualitative (visual) assessment of CT images by a radiologist provides insight into the diagnosis of diffuse lung disease, estimates disease severity, and supports the identification of complications. Quantitative CT (qCT) is an emerging technique that provides some advantages over qualitative assessment. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000440DOI Listing
July 2020
4 Reads

Progression of probable UIP and UIP on HRCT.

Clin Imaging 2019 Nov - Dec;58:140-144. Epub 2019 Jul 12.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

Purpose: To determine patterns of progression of probable Usual Interstitial Pneumonitis (UIP).

Methods: This HIPPA compliant, IRB-approved study draws patients from our Fibrosis Registry. All patients with a consensus diagnosis of Idiopathic Pulmonary Fibrosis (IPF) were included. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.07.003DOI Listing
March 2020
2 Reads

Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation.

Insights Imaging 2019 Jul 16;10(1):73. Epub 2019 Jul 16.

Centro Hospitalar de São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Cigarettes are well-recognized risk factors responsible for the emergence of a variety of pathologic conditions affecting both the airways and the lungs. Smoking-related lung diseases can be classified as chronic obstructive pulmonary disease (COPD) and several types of interstitial diseases, such as pulmonary Langerhans cell histiocytosis, bronchiolitis, desquamative interstitial pneumonitis, acute eosinophilic pneumonia, and interstitial fibrosing lung diseases. The evidence of combined lower lung fibrosis and predominant upper lung emphysema is renowned as a distinct clinical entity, named combined pulmonary fibrosis and emphysema. Read More

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http://dx.doi.org/10.1186/s13244-019-0765-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635572PMC
July 2019
10 Reads

Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer.

Respir Res 2019 Jul 4;20(1):136. Epub 2019 Jul 4.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, South Korea.

Background And Objective: The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors for postoperative pulmonary complications (PPCs) in healthy elderly patients with non-small cell lung cancer (NSCLC) to select optimal candidates for surgical resection in this subpopulation.

Methods: We included 488 patients older than 70 years with normal spirometry results who underwent curative resection for NSCLC (stage IA-IIB) between 2012 and 2016. Read More

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http://dx.doi.org/10.1186/s12931-019-1087-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610954PMC
July 2019
6 Reads

Indium Lung: Discovery, Pathophysiology and Prevention.

Tohoku J Exp Med 2019 07;248(3):143-150

Department of Preventive Medicine and Public Health, Keio University School of Medicine.

Indium is mainly used as indium-tin oxide (ITO), which has a unique character of transparency, and is a requisite in making liquid crystal displays. Pulmonary toxicity of indium compounds in humans were not recognized until the last 2 decades. Several initial human cases of indium-related lung disease, named indium lung, were reported in Japan, with their main pathologic findings being interstitial pneumonia, emphysema and cholesterol crystals-containing granulomas. Read More

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https://www.jstage.jst.go.jp/article/tjem/248/3/248_143/_art
Publisher Site
http://dx.doi.org/10.1620/tjem.248.143DOI Listing
July 2019
5 Reads

Objectively Measured Chronic Lung Injury on Chest CT.

Chest 2019 12 22;156(6):1149-1159. Epub 2019 Jun 22.

Applied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA.

Background: Tobacco smoke exposure is associated with emphysema and pulmonary fibrosis, both of which are irreversible. We have developed a new objective CT analysis tool that combines densitometry with machine learning to detect high attenuation changes in visually normal appearing lung (Norm) that may precede these diseases.

Methods: We trained the classification tool by placing 34,528 training points in chest CT scans from 297 COPDGene participants. Read More

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http://dx.doi.org/10.1016/j.chest.2019.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904856PMC
December 2019
12 Reads

Computer-aided identification of interstitial lung disease based on computed tomography.

J Xray Sci Technol 2019 ;27(4):591-603

Department of Medical Imaging, The First Affiliated Hospital of Xian Jiaotong University, Xi'an, Shaanxi, China.

Objective: Identification of interstitial lung disease (ILD) may be difficult in certain cases using pulmonary function tests (PFTs) or subjective radiological analysis. We evaluated the efficacy of quantitative computed tomography (CT) with 3-dimensional (3D) reconstruction for distinguishing ILD patients from healthy controls.

Materials And Methods: We retrospectively collected chest CT images of 102 ILD patients and 102 healthy matched controls, and measured the following parameters: lung parenchymal volume, emphysema indices low attenuation area LAA910 volume, LAA950 volume, LAA910%, and LAA950%, and mean lung density (MLD) for whole lung, left lung, right lung, and each lobe, respectively. Read More

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http://dx.doi.org/10.3233/XST-180460DOI Listing
January 2019
23 Reads

Visual and Automated CT Measurements of Lung Volume Loss in Idiopathic Pulmonary Fibrosis.

AJR Am J Roentgenol 2019 08 7;213(2):318-324. Epub 2019 May 7.

2 Royal Brompton and Harefield NHS Foundation Trust, London, UK.

The purpose of this study is to establish the relationship between CT markers of lung volume and pulmonary function test (PFT) parameters of lung volume in idiopathic pulmonary fibrosis (IPF). The relationships between PFT-derived parameters of lung volume (forced vital capacity [FVC] and total lung capacity [TLC]) and both CT-derived automated lung volume and manually derived surrogate measurements of lung volume on CT were evaluated in 273 patients (212 men and 61 women; median age, 67 years) with a multidisciplinary diagnosis of IPF. All patients underwent unenhanced volumetric high-resolution CT of the thorax. Read More

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http://dx.doi.org/10.2214/AJR.18.20884DOI Listing
August 2019
6 Reads

CT features of pulmonary interstitial emphysema.

Diagn Interv Imaging 2019 Dec 30;100(12):825-826. Epub 2019 Apr 30.

Department of Cardiovascular and Thoracic Imaging, CHU de Bordeaux, 33600 Pessac, France; Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux University, 33000 Bordeaux, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22115684193009
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http://dx.doi.org/10.1016/j.diii.2019.04.004DOI Listing
December 2019
10 Reads

Chest High-Resolution CT Findings of Microscopic Polyangiitis: A Japanese First Nationwide Prospective Cohort Study.

AJR Am J Roentgenol 2019 Apr 11:1-11. Epub 2019 Apr 11.

1 Department of Respiratory Medicine, Toho University Omori Medical Center, Ota-ku Omori nisi 6-11-1, Tokyo 143-8541, Japan.

Objective: The lung is one of the organs possibly involved in microscopic polyangiitis (MPA), and myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) is commonly found in patients with MPA. The aim of this study was to assess pulmonary lesions in Japanese patients with MPA.

Subjects And Methods: This prospective study was based on 144 patients with MPA who were enrolled in the Remission Induction Therapy in Japanese Patients With ANCA-Associated Vasculitis and Rapidly Progressive Glomerulonephritis Study and who underwent chest high-resolution CT (HRCT) imaging at the time of diagnosis during 2011-2014. Read More

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http://dx.doi.org/10.2214/AJR.18.20967DOI Listing
April 2019
30 Reads

Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review.

BMC Pediatr 2019 03 29;19(1):86. Epub 2019 Mar 29.

Pediatrics and Adolescentology Unit, Department of Internal Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases.

Case Presentation: We report a new pathogenic FLNA gene variant (c.7391_7403del; p. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1460-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440113PMC
March 2019
23 Reads

Pulmonary Acinus: Understanding the Computed Tomography Findings from an Acinar Perspective.

Lung 2019 06 21;197(3):259-265. Epub 2019 Mar 21.

Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

The lung acinus is the most distal portion of the airway responsible for the gas exchange. The normal acini are not visible on conventional computed tomography (CT), but the advent of micro-CT improved the understanding of the microarchitecture of healthy acini. The comprehension of the acinar architecture is pivotal for the understanding of CT findings of diseases that involve the acini. Read More

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http://dx.doi.org/10.1007/s00408-019-00214-7DOI Listing
June 2019
9 Reads

Behavioral Characteristics and Medicolegal Identification of Infanticide.

Fa Yi Xue Za Zhi 2018 06 25;34(6):659-664. Epub 2018 Dec 25.

Institute of Criminal Science and Technology, Pudong Branch of Shanghai Public Security Bureau, Shanghai 220135, China.

Due to the concealment and incidence higher than reported statistics, infanticide should attract the attention of legal medical experts. The infanticide process has common behavioral characteristics. The perpetrators are most frequently biological mothers who are unmarried, with inferior education, and lack of routine pregnancy tests. Read More

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http://dx.doi.org/10.12116/j.issn.1004-5619.2018.06.018DOI Listing
June 2018
41 Reads

Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort.

ERJ Open Res 2019 Feb 18;5(1). Epub 2019 Mar 18.

Respiratory Medicine Dept, University of Thessaly, School of Medicine, Larissa, Greece.

Background: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival.

Methods: This retrospective study included 97 patients with CPFE. Read More

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http://dx.doi.org/10.1183/23120541.00014-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421361PMC
February 2019
9 Reads

Neurofibromatosis type 1: State-of-the-art review with emphasis on pulmonary involvement.

Respir Med 2019 03 17;149:9-15. Epub 2019 Jan 17.

Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Neurofibromatosis type 1 (NF-1), also known as von Recklinghausen's disease, is an autosomal dominant dysplasia of the ectoderm and mesoderm with a variable clinical expression, but near-complete penetrance before the age of 5 years. The estimated incidence is 1 in 3000 births. NF-1 is characterized by collections of neurofibromas, café-au-lait spots, axillary and inguinal freckling, and pigmented hamartomas in the iris (Lisch nodules). Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.002DOI Listing
March 2019
7 Reads

Chest computed tomography imaging improves potential lung donor assessment.

J Thorac Cardiovasc Surg 2019 04 24;157(4):1711-1718.e1. Epub 2018 Nov 24.

Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Miss. Electronic address:

Objective: Chest computed tomography (CT) imaging is being increasingly used for potential lung donor assessment. However, the efficacy of CT imaging in this setting remains unknown. We hypothesize that chest CT imaging independently affects the decision-making process in donor lung utilization. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486796PMC
April 2019
9 Reads

Clinical features of thirty-two patients with anti-melanoma differentiation-associated gene 5 antibodies.

Clin Exp Rheumatol 2019 Sep-Oct;37(5):803-807. Epub 2019 Feb 11.

Department of Rheumatology and Immunology of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies.

Methods: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed.

Results: Of the 32 anti-MDA5 antibody-positive patients, eleven patients were clinically diagnosed with interstitial pneumonia with autoimmune features (IPAF), ten patients were diagnosed with clinically amyopathic dermatomyositis (CADM), six patients were diagnosed with dermatomyositis (DM) and five patients were diagnosed with anti-synthetase syndrome (ASS). Read More

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October 2019
10 Reads
2.724 Impact Factor

Advanced interstitial lung fibrosis with emphysema and pulmonary hypertension with no evidence for interstitial lung disease on high resolution CT.

Pulm Circ 2019 Jul-Sep;9(3):2045894019832214

1 Medical University of Graz, Department of Internal Medicine, Division of Pulmonology, Graz, Austria.

The diagnosis of idiopathic pulmonary arterial hypertension (iPAH) is complex and, besides invasive hemodynamic evaluation, includes several diagnostic steps to exclude any underlying diseases. The role of a decreased diffusion capacity of the lung for carbon monoxide (DLCO) is a matter of discussion. Here, we present a 76-year-old man with a smoking history of 30 pack-years who was diagnosed with iPAH after chronic thromboembolic pulmonary hypertension was excluded based on a negative perfusion scan, an underlying heart disease was excluded based on echocardiography and right heart catheterization, and a significant lung disease was excluded based on lung function test (FVC = 101% predicted, FEV1 = 104% predicted, FEV1/FVC = 77, TLC = 97% predicted) and thin-slice computed tomography (CT) scan. Read More

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http://dx.doi.org/10.1177/2045894019832214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614945PMC
February 2019
1 Read

Distribution of emphysema and fibrosis in idiopathic pulmonary fibrosis with coexisting emphysema.

Histopathology 2019 Jun;74(7):1103-1108

Department of Pathology, Fukuoka University School of Medicine and Hospital, Fukuoka, Japan.

Aims: Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that results from tobacco smoking. Emphysema and fibrosis in CPFE patients have been considered to exist separately, with emphysema in the upper lobes and interstitial pneumonia in the lower lobes. The aim of this study was to examine the intrapulmonary distribution of fibrosis and emphysema in clinically diagnosed patients with idiopathic pulmonary fibrosis (IPF) and coexisting emphysema. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13831
Publisher Site
http://dx.doi.org/10.1111/his.13831DOI Listing
June 2019
18 Reads

Anti-RNA binding protein positivity in idiopathic interstitial pneumonia.

Respir Med 2019 01 22;146:23-27. Epub 2018 Nov 22.

Section of Pulmonary & Critical Care, Department of Medicine, The University of Chicago, Chicago, IL, USA.

Introduction: Idiopathic interstitial pneumonias (IIP) are diffuse lung diseases whose cause is unknown and often present with features of autoimmunity despite not meeting criteria for a connective tissue disease (CTD). Recent studies suggest that anti-RNA binding protein (anti-RBP) antibodies, which include anti-SSA, anti-SSB, anti-Sm, and anti-RNP, play a role in the loss of immune tolerance and severity of pulmonary hypertension (PH) in CTDs. We hypothesized that anti-RBP positive (RBP+) subjects would have worse measures of lung function, radiographic findings, PH, and survival than anti-RBP negative (RBP-) subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183037
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http://dx.doi.org/10.1016/j.rmed.2018.11.015DOI Listing
January 2019
21 Reads

Combined pulmonary fibrosis and emphysema as a clinicoradiologic entity: Characterization of presenting lung fibrosis and implications for survival.

Respir Med 2019 01 13;146:106-112. Epub 2018 Dec 13.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: The prevalence of classifiable and unclassifiable causes of lung fibrosis and its implications for survival are mostly unknown in combined pulmonary fibrosis and emphysema (CPFE).

Materials And Methods: Patients with >10% involvement of both emphysema and lung fibrosis seen over 11 years at our institution were reviewed independently by expert radiologists for fibrotic and emphysematous findings and overall fibrotic CT pattern. Underlying interstitial lung disease (ILD) diagnoses and baseline demographic and clinical characteristics were collated and assessed for predictors of comparative survival. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183038
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http://dx.doi.org/10.1016/j.rmed.2018.12.003DOI Listing
January 2019
37 Reads
3.086 Impact Factor

Pleuroparenchymal fibroelastosis-like lesions on chest computed tomography in routine clinical practice.

Jpn J Radiol 2019 Mar 1;37(3):230-236. Epub 2019 Jan 1.

Department of Radiology, Osaka Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: To evaluate the incidence and changes in the pleuroparenchymal fibroelastosis (PPFE)-like lesions on chest CT in routine clinical practice.

Materials And Methods: This study included 1284 patients who underwent chest CT in 2011 at a hospital. The incidence of PPFE-like lesions and their correlation with age, body mass index, and concomitant pulmonary findings were assessed. Read More

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http://dx.doi.org/10.1007/s11604-018-0805-5DOI Listing
March 2019
14 Reads

Emphysema extent on computed tomography is a highly specific index in diagnosing persistent airflow limitation: a real-world study in China.

Int J Chron Obstruct Pulmon Dis 2019;14:13-26. Epub 2018 Dec 17.

Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Objective: The diagnostic value of emphysema extent in consistent air flow limitation remains controversial. Therefore, we aimed to assess the value of emphysema extent on computed tomography (CT) on the diagnosis of persistent airflow limitation. Furthermore, we developed a diagnostic criterion for further verification. Read More

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http://dx.doi.org/10.2147/COPD.S157141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301435PMC
July 2019
5 Reads

Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2019 04;16(4):447-454

1 Pulmonary Critical Care Medicine.

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede the development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data derived from imaging studies.

Objectives: To assess quantitative measures of airway wall thickness (AWT) in populations characterized for interstitial lung abnormalities (ILA) and for IPF.

Methods: Computed tomographic imaging of the chest and measures of AWT were available for 6,073, 615, 1,167, and 38 participants from COPDGene (Genetic Epidemiology of COPD study), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study), and the Framingham Heart Study (FHS) and in patients with IPF from the Brigham and Women's Hospital Herlihy Registry, respectively. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201806-424OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441702PMC
April 2019
31 Reads

Comparative evaluation of ultrasonography with clinical respiratory score in diagnosis and prognosis of respiratory diseases in weaned dairy buffalo and cattle calves.

J Anim Sci Technol 2018 3;60:29. Epub 2018 Dec 3.

2Klinik für Klauentiere, Freie Universität Berlin, 14163 Berlin, Germany.

Background: Respiratory troubles have economic impacts in countries where livestock industry is an important segment of the agricultural sector, as well as these problems may cause significant economic losses for bovine producers. Various practical methods are used to assess diseases that affect the bovine respiratory system. Ultrasonography is a noninvasive tool that has been used frequently in diagnosis of various animal diseases. Read More

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http://dx.doi.org/10.1186/s40781-018-0187-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276192PMC
December 2018
4 Reads

Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):528-530

Department of Surgery; Division of Cardiothoracic Surgery; Pediatric and Congenital Cardiac Surgery Section Jackson Memorial Hospital - University of Miami Miller School of Medicine, Miami, USA.

Pulmonary interstitial emphysema (PIE) is a common problem in premature neonates with respiratory distress syndrome. This condition is often related to barotrauma caused by mechanical ventilation or continuous positive airway pressure applied to low birth weight neonates. The clinical diagnosis can be challenging. Read More

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http://dx.doi.org/10.21470/1678-9741-2018-0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257528PMC
March 2019
16 Reads

Reduced area of the normal lung on high-resolution computed tomography predicts poor survival in patients with lung cancer and combined pulmonary fibrosis and emphysema.

Respir Investig 2019 Mar 22;57(2):140-149. Epub 2018 Nov 22.

Department of Respiratory Medicine, Respiratory Centre, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan; Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan. Electronic address:

Background: This study aimed to determine the radiologic predictors and clarify the clinical features related to survival in patients with combined pulmonary fibrosis and emphysema (CPFE) and lung cancer.

Methods: We retrospectively reviewed the medical chart data and high-resolution computed tomography (HRCT) findings for 81 consecutive patients with CPFE and 92 primary lung cancers (70 men, 11 women; mean age, 70.9 years). Read More

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http://dx.doi.org/10.1016/j.resinv.2018.10.007DOI Listing
March 2019
8 Reads

Prognostic impact of underlying lung disease in pulmonary wedge resection for lung cancer.

Int J Clin Oncol 2019 Apr 15;24(4):366-374. Epub 2018 Nov 15.

Department of Thoracic and Cardiovascular Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Pulmonary wedge resection is an option for lung cancer patients with limited cardiopulmonary preservation. As the impact of underlying lung status on the prognosis of such patients remains unclear, we assessed this issue.

Methods: A total of 149 borderline surgical candidates with localized lung cancer who had undergone wedge resection were retrospectively investigated. Read More

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http://link.springer.com/10.1007/s10147-018-1367-3
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http://dx.doi.org/10.1007/s10147-018-1367-3DOI Listing
April 2019
45 Reads

Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema.

Biomarkers 2019 May 19;24(3):232-239. Epub 2018 Nov 19.

a Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.

The aetiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort of patients with emphysema, interstitial pulmonary fibrosis (IPF), and CPFE. Explanted lungs were obtained from subjects with emphysema, IPF, CPFE, (or normal subjects), and tissue extracts were prepared. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2018.1
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http://dx.doi.org/10.1080/1354750X.2018.1542458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509019PMC
May 2019
23 Reads

Combined pulmonary fibrosis and emphysema in systemic sclerosis: A syndrome associated with heavy morbidity and mortality.

Semin Arthritis Rheum 2019 08 13;49(1):98-104. Epub 2018 Oct 13.

Department of Internal Medicine, Service de Médecine Interne, Hôpital Cochin, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, DHU Authors (Autoimmune and Hormonal Diseases), Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. Electronic address:

Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) primarily due to tobacco smoking has been reported in connective tissue disease, but little is known about its characteristics in systemic sclerosis (SSc).

Methods: In this retrospective multi-center case-control study, we identified 36 SSc patients with CPFE, and compared them with 72 SSc controls with interstitial lung disease (ILD) without emphysema.

Results: Rate of CPFE in SSc patients with CT scan was 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172173051
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.011DOI Listing
August 2019
23 Reads

Searching for the Source of the Leak: PIE and the Macklin Effect.

Ann Am Thorac Soc 2018 11;15(11):1354-1356

3 Department of Radiology, Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.1513/AnnalsATS.201803-200CCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322014PMC
November 2018

Interstitial lung abnormalities in the Queensland Lung Cancer Screening Study: prevalence and progression over 2 years of surveillance.

Intern Med J 2019 07;49(7):843-849

University of Queensland Thoracic Research Centre, Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia.

Background: We report the prevalence and progression of incidentally detected interstitial lung abnormalities (ILA) in the Queensland Lung Cancer Screening Study cohort.

Methods: About 256 volunteers aged 60-74, with ≥30 pack years smoking history and forced expiratory volume in 1 s (FEV1) ≥50% predicted underwent low-dose computed tomography (CT) chest screening. Electronic search of baseline (T0) and 2-year follow-up (T2) CT reports identified candidate cases using Fleischner Society interstitial terminology. Read More

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http://doi.wiley.com/10.1111/imj.14148
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http://dx.doi.org/10.1111/imj.14148DOI Listing
July 2019
55 Reads

Imaging Advances in Chronic Obstructive Pulmonary Disease. Insights from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) Study.

Am J Respir Crit Care Med 2019 02;199(3):286-301

7 Department of Radiology, National Jewish Health, Denver, Colorado.

The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study, which began in 2007, is an ongoing multicenter observational cohort study of more than 10,000 current and former smokers. The study is aimed at understanding the etiology, progression, and heterogeneity of chronic obstructive pulmonary disease (COPD). In addition to genetic analysis, the participants have been extensively characterized by clinical questionnaires, spirometry, volumetric inspiratory and expiratory computed tomography, and longitudinal follow-up, including follow-up computed tomography at 5 years after enrollment. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201807-1351SO
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http://dx.doi.org/10.1164/rccm.201807-1351SODOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363977PMC
February 2019
10 Reads

Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema.

Rev Esp Patol 2018 Oct - Dec;51(4):257-261. Epub 2018 Mar 14.

From the Department of Pneumology, University General Hospital, Valencia, Spain; From the Departement of Medicine. Valencia University, Valencia, Spain.

Smoking-related interstitial fibrosis is a distinct form of fibrosis, found in smokers, which has striking histopathological features. We present a case of pulmonary interstitial fibrosis with cysts in a 58-year-old woman who was a significant active smoker, presenting with a 7 month history of progressive dyspnea. TAC revealed thin-walled pulmonary cysts. Read More

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http://dx.doi.org/10.1016/j.patol.2018.01.005DOI Listing
November 2019
12 Reads