658 results match your criteria Imaging Pulmonary Interstitial Emphysema


The Normal Lung Index From Quantitative Computed Tomography for the Evaluation of Obstructive and Restrictive Lung Disease.

J Thorac Imaging 2022 Jul 16;37(4):246-252. Epub 2021 Dec 16.

Pontificia Universidade Catolica do Rio Grande do Sul.

Purpose: Our objective was to evaluate whether the normal lung index (NLI) from quantitative computed tomography (QCT) analysis can be used to predict mortality as well as pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD).

Materials And Methods: Normal subjects (n=20) and patients with COPD (n=172) and ILD (n=114) who underwent PFTs and chest CT were enrolled retrospectively in this study. QCT measures included the NLI, defined as the ratio of the lung with attenuation between -950 and -700 Hounsfield units (HU) over the total lung volume (-1024 to -250 HU, mL), high-attenuation area (-700 to -250 HU, %), emphysema index (>6% of pixels < -950 HU), skewness, kurtosis, and mean lung attenuation. Read More

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Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries.

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.

Purpose: The aim of this study was to analyse and quantify the prevalence of six comorbidities from lung cancer screening (LCS) on computed tomography (CT) scans of patients from developing countries.

Methods: For this retrospective study, low-dose CT scans (n=775) were examined from patients who underwent LCS in a tertiary hospital between 2016 and 2020. An age- and sex-matched control group was obtained for comparison (n=370). Read More

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Investigating the Incidence of Pulmonary Abnormalities as Identified by Parametric Response Mapping in Patients With Lung Cancer Before Radiation Treatment.

Adv Radiat Oncol 2022 Jul-Aug;7(4):100980. Epub 2022 Apr 25.

Departments of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

Purpose: Parametric response mapping (PRM) of high-resolution, paired inspiration and expiration computed tomography (CT) scans is a promising analytical imaging technique that is currently used in diagnostic applications and offers the ability to characterize and quantify certain pulmonary pathologies on a patient-specific basis. As one of the first studies to implement such a technique in the radiation oncology clinic, the goal of this work was to assess the feasibility for PRM analysis to identify pulmonary abnormalities in patients with lung cancer before radiation therapy (RT).

Methods And Materials: High-resolution, paired inspiration and expiration CT scans were acquired from 23 patients with lung cancer as part of routine treatment planning CT acquisition. Read More

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Follow-Up CT Patterns of Residual Lung Abnormalities in Severe COVID-19 Pneumonia Survivors: A Multicenter Retrospective Study.

Tomography 2022 04 20;8(3):1184-1195. Epub 2022 Apr 20.

Department of Medicine and Surgery (DiMec), University of Parma, 43126 Parma, Italy.

Prior studies variably reported residual chest CT abnormalities after COVID-19. This study evaluates the CT patterns of residual abnormalities in severe COVID-19 pneumonia survivors. All consecutive COVID-19 survivors who received a CT scan 5-7 months after severe pneumonia in two Italian hospitals (Reggio Emilia and Parma) were enrolled. Read More

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Interstitial lung abnormalities and interstitial lung diseases associated with cigarette smoking in a rural cohort undergoing surgical resection.

BMC Pulm Med 2022 Apr 29;22(1):172. Epub 2022 Apr 29.

Deparment of Pathology, West Virginia University, Morgantown, WV, USA.

Background: Cigarette smoking is a risk factor for interstitial lung abnormalities (ILAs) and interstitial lung diseases (ILDs). Investigation defining the relationships between ILAs/ILDs and clinical, radiographic, and pathologic findings in smokers have been incomplete. Employing a cohort undergoing surgical resection for lung nodules/masses, we (1) define the prevalence of ILAs/ILDs, (2) delineate their clinical, radiographic and pathologic predictors, and (3) determine their associations with mortality. Read More

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Can Interstitial Lung Abnormalities Explain a High FVC in a Smoker With Emphysema?

Chest 2022 04;161(4):872-873

Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA; Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY. Electronic address:

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Spontaneous pneumomediastinum with subcutaneous emphysema in a patient with rheumatoid arthritis and interstitial pneumonia.

BMJ Case Rep 2022 04 1;15(4). Epub 2022 Apr 1.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

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Pulmonary interstitial emphysema and complications: incidence and CT findings in COVID-19.

Lung India 2022 Mar-Apr;39(2):174-176

Department of Radiology, Suny Upstate Medical University Hospital, Siracuse, NY, USA.

Background And Objectives: There are scant data available in the published literature providing chest computed tomography (CT) findings on pulmonary interstitial emphysema (PIE), complications and associated parenchymal abnormalities. We report the incidence of PIE and complications by chest CT in patients with COVID-19.

Methods: We retrospective analyzed 897 chest CT scans performed with 64-slice CT scanners during the COVID-19 pandemic period from March 2020 to September 2021. Read More

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Clinical Outcomes of Patients with Combined Idiopathic Pulmonary Fibrosis and Emphysema in the IPF-PRO Registry.

Lung 2022 02 7;200(1):21-29. Epub 2022 Jan 7.

Cleveland Clinic, Cleveland, OH, USA.

Purpose: To assess the impact of concomitant emphysema on outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods: The IPF-PRO Registry is a US registry of patients with IPF. The presence of combined pulmonary fibrosis and emphysema (CPFE) at enrollment was determined by investigators' review of an HRCT scan. Read More

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February 2022

Screening for Preclinical Parenchymal Lung Disease in Rheumatoid Arthritis.

Rheumatology (Oxford) 2021 Dec 7. Epub 2021 Dec 7.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: Pulmonary disease is a common extraarticular manifestation of rheumatoid arthritis (RA) associated with increased morbidity and mortality. No current strategies exist for screening this at-risk population for parenchymal lung disease, including emphysema and interstitial lung disease (ILD).

Methods: RA patients without a diagnosis of ILD or chronic obstructive pulmonary disease underwent prospective and comprehensive clinical, laboratory, functional, and radiologic evaluations. Read More

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December 2021

[Two case reports: chronic obstructive pulmonary disease developed in long term survived patients after acute paraquat poisoning].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Sep;33(9):1136-1138

Department of Emergency, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China. Corresponding author: Xu Jiyang, Email:

Patients with acute paraquat poisoning mostly die of respiratory failure, and the surviving ones may live with pulmonary fibrosis, but the long-term changes in lung function are still un-clear. Two patients with acute paraquat poisoning survived for more than 7 years were followed up in Northern Jiangsu People's Hospital to evaluate the imaging and spirometric changes. Eight years after poisoning, 1 patient's chest computerized tomography (CT) revealed interstitial pneumonia, chronic bronchitis, emphysema, accompanied by bronchiectasis. Read More

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September 2021

Unusual lung adenocarcinoma spread along with pulmonary emphysema.

Respirol Case Rep 2021 Dec 8;9(12):e0874. Epub 2021 Nov 8.

Department of Respiratory Medicine Fukuoka University Chikushi Hospital Chikushino Japan.

Lung adenocarcinoma can rarely present with imaging findings that mimic fibrotic lesions of interstitial pneumonia. Asymmetric lung involvement and symptoms of haemoptysis may be the clinical clues to the suspicion of lung neoplasm rather than fibrotic lung disease. Read More

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December 2021

Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers.

Chest 2022 04 3;161(4):999-1010. Epub 2021 Nov 3.

Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

Background: Most pulmonary conditions reduce FVC, but studies of patients with combined pulmonary fibrosis and emphysema demonstrate that reductions in FVC are less than expected when these two conditions coexist clinically.

Research Question: Do interstitial lung abnormalities (ILAs), chest CT imaging findings that may suggest an early stage of pulmonary fibrosis in individuals with undiagnosed disease, affect the association between emphysema and FVC?

Study Design And Methods: Measures of ILA and emphysema were available for 9,579 and 5,277 participants from phases 1 (2007-2011) and 2 (2012-2016) of the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study (COPDGene), respectively. ILA were defined by Fleischner Society guidelines. Read More

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Interobserver agreement of interstitial lung fibrosis Reporting and Data System (ILF-RADS) at high-resolution CT.

Emerg Radiol 2022 Feb 27;29(1):115-123. Epub 2021 Oct 27.

Faculty of Medicine, Horus University, New Damietta City, Egypt.

Purpose: To assess the interobserver agreement of interstitial lung fibrosis Reporting and Data System (ILF-RADS) in interpretation and categorization of interstitial lung disease (ILD) at high-resolution CT (HRCT).

Methods: Retrospective analysis was performed on 65 consecutive patients (36 male and 29 female), median age 53 years, who were referred to the Radiology Department, Mansoura University, in the period from July 2016 to February 2020. They were expected clinically to have diffuse lung disease and underwent HRCT of the chest. Read More

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February 2022

COVID-19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications.

Emerg Radiol 2022 Feb 26;29(1):23-34. Epub 2021 Oct 26.

Department of Radiology & Biomedical Imaging, Yale School of Medicine; Thoracic Imaging section, Yale-New Haven Hospital, Yale New Haven Health, New Haven, CT, USA.

The first cluster of cases of COVID-19 pneumonia was reported on December 31, 2019. Since then, this disease has spread rapidly across the world, and as of September 17, 2021, there are 226,844,344 cases of COVID-19 worldwide with 4,666,334 deaths related to COVID-19. While most COVID-19 cases are mild, some cases are severe with patients developing acute respiratory distress syndrome (ARDS). Read More

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February 2022

[Follow-up study of patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Aug;44(8):717-722

Department of Ultrasound, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China C.

To investigate the relationship between clinical characteristics of patients with chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) and COPD exacerbation over a three-year observation period. A total of 366 cases of stable COPD patients were enrolled from the Department of Respiratory Medicine of the First Affiliated Hospital of Henan University of Science and Technology. The patients underwent pulmonary function tests(PFT), COPD assessment test (CAT), Saint George's respiratory questionnaire (SGRQ), transthoracic echocardiogrophy(TTE), chest CT and biochemical detection. Read More

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A rare etiology of pulmonary nodules.

Respir Med Case Rep 2021 22;34:101519. Epub 2021 Sep 22.

Department of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA, USA.

Introduction: Pulmonary nodules are a frequent finding on chest imaging studies, with differential including multiple benign entities, but malignancy is often also a concern. Computed Tomography (CT) and Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET) scans have improved the characterization of pulmonary nodules. However, many nodules remain indeterminate and require periodic monitoring. Read More

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September 2021

A Pilot Study to Estimate the Impact of High Matrix Image Reconstruction on Chest Computed Tomography.

J Clin Imaging Sci 2021 30;11:52. Epub 2021 Sep 30.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States.

Objectives: The objectives of the study were to estimate the impact of high matrix image reconstruction on chest computed tomography (CT) compared to standard image reconstruction.

Material And Methods: This retrospective study included patients with interstitial or parenchymal lung disease, airway disease, and pulmonary nodules who underwent chest CT. Chest CT images were reconstructed using high matrix (1024 × 1024) or standard matrix (512 × 512), with all other parameters matched. Read More

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September 2021

Chest high-resolution computed tomography in patients with connective tissue disease: pulmonary conditions beyond "the usual suspects".

Curr Probl Diagn Radiol 2021 Aug 29. Epub 2021 Aug 29.

Institute of Radiology, Department of Medicine, University of Udine, "S. Maria della Misericordia" University Hospital, p.le S. Maria della Misericordia, 15 - 33100 Udine, Italy.

The term "connective tissue diseases" (CTDs) refers to a heterogeneous group of autoimmune disorders, including systemic sclerosis, rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, polymyositis, dermatomyositis, antisynthetase syndrome, and mixed connective tissue disease. Chest high-resolution computed tomography (HRCT) is the imaging method of choice for evaluating patients with known or suspected CTD-related interstitial lung disease (CTD-ILD), a complication accounting for substantial morbidity and mortality. While specific HRCT patterns and signs of CTD-ILD have been extensively described (hence the designation "the usual suspects"), the knowledge of various, less frequent conditions involving the lungs in patients with CTD would help the radiologist produce a clinically valuable report, thus potentially influencing patient management. Read More

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Pneumomediastinum and Pneumothorax as Relevant Complications of Sub-Intensive Care of Patients with COVID-19: Description of a Case Series.

Medicina (Kaunas) 2021 Sep 1;57(9). Epub 2021 Sep 1.

Sub Intensiva COVID PO Ospedale del Mare ASL Napoli 1 Centro, 80147 Naples, Italy.

Lung failure has been the most common cause of hospitalization for COVID-19. Yet, bilateral interstitial pneumonia has not been the only cause of lung failure of these inpatients, and frequently they develop other illnesses associated with COVID-19. Pulmonary embolism has been the most looked for in the world, but rarely other pneumological diseases, such as pneumothorax and pneumomediastinum, have been described and associated with a worsening prognosis. Read More

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September 2021

Predictive Factors for Pneumomediastinum During Management of Connective Tissue Disease-related Interstitial Lung Disease: A Retrospective Study.

Intern Med 2021 15;60(18):2887-2897. Epub 2021 Sep 15.

Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.

Objective To identify factors associated with pneumomediastinum during management of connective tissue disease (CTD)-related interstitial lung disease (ILD). Methods Patients diagnosed with pneumomediastinum after the initiation of corticosteroid therapy for their CTD-ILD were enrolled. The baseline characteristics of patients who developed pneumomediastinum after the initiation of corticosteroid therapy (n=13, all occurring within 120 days) were compared to those of patients who did not develop pneumomediastinum (n=49). Read More

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September 2021

Impact of Gender on the Characteristics of Patients with Idiopathic Pulmonary Fibrosis Included in the RaDiCo-ILD Cohort.

Respiration 2022;101(1):34-45. Epub 2021 Sep 2.

Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Pneumologie Pédiatrique, Centre de Référence des Maladies Respiratoires Rares, Paris, France.

Background: There is growing evidence of gender-specific phenotypic differences among patients with idiopathic pulmonary fibrosis (IPF), which may affect patient outcomes.

Objectives: We present the characteristics of patients with IPF at inclusion in the French Rare Disease Cohort - Interstitial Lung Disease (RaDiCo-ILD) with the aim of characterizing gender-specific phenotypic differences.

Methods: Patients with IPF who were enrolled in the national, multicentre RaDiCo-ILD cohort were included. Read More

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Predicting Respiratory Complications Following Lobectomy Using Quantitative CT Measures of Emphysema.

Int J Chron Obstruct Pulmon Dis 2021;16:2523-2531. Epub 2021 Sep 4.

Department of General Thoracic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: In performing surgery for lung cancer, emphysema is a risk factor related to postoperative respiratory complications (PRC). However, few studies have addressed the risk of radiological emphysematous volume affecting PRC. The aim of this study was to investigate the relationship between emphysematous volume as measured on 3-dimensional computed tomography and PRC. Read More

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October 2021

Survival analysis in lung cancer patients with interstitial lung disease.

PLoS One 2021 7;16(9):e0255375. Epub 2021 Sep 7.

Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Objective: Lung cancer patients with interstitial lung disease (ILD) are prone for higher morbidity and mortality and their treatment is challenging. The purpose of this study is to investigate whether the survival of lung cancer patients is affected by the presence of ILD documented on CT.

Materials And Methods: 146 patients with ILD at initial chest CT were retrospectively included in the study. Read More

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December 2021

COVID19 pneumonia with cavitation and cystic lung changes: multi-detector computed tomography spectrum of a gamut of etiologies.

BJR Open 2021 29;3(1):20210007. Epub 2021 Jul 29.

Department of Radio-diagnosis, University College of Medical Sciences and GTB Hospital (University of Delhi) Dilshad Graden, New Delhi, India.

The COVID19 pandemic since its beginning in March 2020, continues to wreak havoc causing great morbidity and mortality with each passing day. Ample literature is now available describing the imaging features of COVID19 infection; however, there is still a paucity of knowledge on the various causes of pulmonary cavitation and cystic lesions which can be associated with the virus albeit uncommonly. Cavitation in a COVID19 positive patient could be a consequence of the infection itself or a manifestation of sinister etiologies like coinfection with bacterial, fungal or mycobacterial pathogens, or incidental malignancy/metastasis. Read More

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Emphysematous Lung Lesions Caused by Perivascular and Alveolar-Septal Deposition of Amyloid Light-Chain Amyloidosis.

Chest 2021 08;160(2):e169-e171

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.

Pulmonary amyloidosis, whether isolated or seen as part of systemic amyloidosis, has a variety of radiographic manifestations. Known parenchymal lung findings include reticulonodular opacities, diffuse interstitial infiltrates, or cystic lesions. Here, we present a case of systemic amyloid light-chain (AL) amyloidosis presenting with severe exertional dyspnea and emphysematous lung lesions on chest CT, a finding described only once before. Read More

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Thoracic radiographic features of fatal paraquat intoxication in eleven dogs.

Vet Q 2021 Dec;41(1):217-225

Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.

Background: Paraquat (1,1-dimethyl-4,4-bipyridinium dichloride) is a toxic herbicide. Accidental ingestion of paraquat in animals and humans causes respiratory failure and death.

Aim: To describe the radiographic features of confirmed paraquat intoxication in a group of dogs and determines whether any identified features can facilitate this diagnosis. Read More

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December 2021

Adolescent-onset anti-MDA5 antibody-positive juvenile dermatomyositis with rapidly progressive interstitial lung disease and spontaneous pneumomediastinum: a case report and literature review.

Pediatr Rheumatol Online J 2021 Jun 30;19(1):103. Epub 2021 Jun 30.

Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong SAR.

Background: Dermatomyositis with positive anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody has a distinct phenotype associated with small hand joint arthritis, mucocutaneous ulceration, palmar papules and less muscle involvement. It is also associated with increased risk of rapidly progressive interstitial lung disease (RP-ILD) and has a high mortality rate in adults. There is evidence that cases complicated with spontaneous pneumomediastinum (PNM) have an increase in mortality. Read More

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Clinical Features and Outcomes of Combined Pulmonary Fibrosis and Emphysema After Lung Transplantation.

Chest 2021 11 26;160(5):1743-1750. Epub 2021 Jun 26.

Division of Pulmonary & Critical Care, Department of Medicine, Washington University School of Medicine, St. Louis, MO. Electronic address:

Background: Combined pulmonary fibrosis and emphysema (CPFE) is recognized as a characteristic syndrome of smoking-related interstitial lung disease that has a worse prognosis than idiopathic pulmonary fibrosis (IPF). However, outcomes after lung transplantation for CPFE have not been reported. The aim of this study is to describe the clinical features and outcomes of CPFE after lung transplantation. Read More

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November 2021

Automated Diseased Lung Volume Percentage Calculation in Quantitative CT Evaluation of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.

J Comput Assist Tomogr 2021 Jul-Aug 01;45(4):649-658

From the First Department of Internal Medicine, Shinshu University School of Medicine.

Objective: Several software-based quantitative computed tomography (CT) analysis methods have been developed for assessing emphysema and interstitial lung disease. Although the texture classification method appeared to be more successful than the other methods, the software programs are not commercially available, to our knowledge. Therefore, this study aimed to investigate the usefulness of a commercially available software program for quantitative CT analyses. Read More

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September 2021