1,550 results match your criteria Imaging in Chordoma

Survey of clinician opinions on the role of proton beam therapy in Australia and New Zealand.

J Med Imaging Radiat Oncol 2020 Oct 13;64(5):689-696. Epub 2020 Sep 13.

Crown Princess Mary Cancer Centre in Westmead, Westmead Hospital, Westmead, New South Wales, Australia.

Introduction: We surveyed the Australian and New Zealand (ANZ) radiation oncology community to assess their perceptions, understanding and experience of the current role of proton beam therapy (PBT) and the existing referral process to access PBT overseas, ahead of the development of the first PBT centre in Australia.

Methods: The survey was conducted between September and October 2019 using a 17-question instrument, which was distributed by email to all 632 radiation oncology fellows and trainees listed in the Royal Australian and New Zealand College of Radiologists database.

Results: One hundred and one respondents completed the survey, with an overall response rate of 16%. Read More

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October 2020

Results following surgical resection of recurrent chordoma of the spine: experience in a single institution.

World J Surg Oncol 2020 Aug 27;18(1):228. Epub 2020 Aug 27.

Department of Orthopedic, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Chordoma of the spine is a low-grade malignant tumor with vague and indolent symptoms; thus, large tumor mass is encountered at the time of diagnosis in almost cases and makes it difficult for en-bloc free-margin resection. Salvage therapy for recurrent chordoma is very challenging due to its relentless nature and refractory to adjuvant therapies. The aim of this present study was to report the oncologic outcome following surgical resection of chordoma of the spine. Read More

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Exophytic Lumbar Vertebral Body Mass in an Adult with Back Pain.

AJNR Am J Neuroradiol 2020 10 20;41(10):1786-1790. Epub 2020 Aug 20.

From the Departments of Radiology (J.C.B., D.K.K., C.C., L.E., F.D.).

Chordomas are rare primary bone malignancies derived from notochord remnants. The tumors often are slow-growing and often present with indolent, nonspecific symptoms. Nevertheless, chordomas are locally aggressive and highly prone to local recurrence, necessitating precise planning before biopsy and/or surgical resection. Read More

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October 2020

Retrorectal tumor: a single-center 10-years' experience.

Ann Surg Treat Res 2020 Aug 31;99(2):110-117. Epub 2020 Jul 31.

Department of General Surgery, Çukurova University Faculty of Medicine, Adana, Turkey.

Purpose: Retrorectal tumors (RTs) are a rare incidence and recommendations on the ideal surgical approaches are lacking. This study aimed to evaluate outcomes and follow-up results of patients undergoing excision of RTs at our institution.

Methods: A retrospective review was conducted for undergoing surgery for RT between January 2009 and January 2019. Read More

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Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy.

World Neurosurg 2020 11 10;143:319-324. Epub 2020 Aug 10.

Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Translational Spine Research Lab, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Background: Chordomas are rare, locally malignant tumors derived from remnants of the notochord that can manifest anywhere in the spine or base of the skull. Surgical treatment for chordomas of the lumbar spine often fails to achieve successful en bloc resection, which is critical to minimizing recurrence risk.

Case Description: In this case report, the authors describe total en bloc resection of a lumbar vertebral body chordoma via the first documented approach of navigated ultrasonic osteotomy for spondylectomy. Read More

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November 2020

Clivus Chordoma: Case Report and Current Considerations on Treatment Strategies.

J Int Adv Otol 2020 Aug;16(2):286-290

Division of Otolaryngology, Department of Neurosciences DNS, Padova University, Padova, Italy.

Chordomas are the rare malignant bone lesions derived from the embryonic notochord. They are slow-growing tumors with a locally aggressive behavior. The clival chordomas are extradural, exophytic, and lytic lesions centered on the clivus, and are managed differently from those arising elsewhere because of the emphasis on preserving the neurological function. Read More

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Free Vascularized Fibula Graft with Femoral Allograft Sleeve for Lumbar Spine Defects After Spondylectomy of Malignant Tumors: A Case Report.

JBJS Case Connect 2020 Jul-Sep;10(3):e2000075

1Department of Orthopedic Surgery, Orthopedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 2Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 3Department of Vascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 4Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 5Department of Orthopedic Surgery, Hand and Upper Extremity Service, Orthopedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Case: We present a 65-year-old man with an L4 conventional chordoma. Total en bloc spondylectomy (TES) of the involved vertebral bodies and surrounding soft tissues with reconstruction of the spine using a free vascularized fibula autograft (FVFG) is a proven technique, limiting complications and recurrence. However, graft fracture has occurred only in the lumbar spine in our institutional cases. Read More

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Strategy for the Practice of Spine Oncological Surgery During the Covid-19 Pandemic.

Spine (Phila Pa 1976) 2020 Oct;45(19):1386-1394

GSpine4 Spine Surgery Division, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Study Design: Case series.

Objective: For each of the most frequent clinical scenarios, the authors reached a consensus on how should be timing and indications be optimized to reduce risk while maintaining the expected outcomes under the Covid-19 pandemics.

Summary Of Background Data: The organization of health care has been changed by the Covid-19 pandemic with a direct impact on Spine Oncology Surgery. Read More

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October 2020

Bone up on spinal osseous lesions: a case review series.

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

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Clinical findings in families with chordoma with and without T gene duplications and in patients with sporadic chordoma reported to the Surveillance, Epidemiology, and End Results program.

J Neurosurg 2020 Jun 19:1-10. Epub 2020 Jun 19.

1Division of Cancer Epidemiology & Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda.

Objective: To gain insight into the role of germline genetics in the development of chordoma, the authors evaluated data from 2 sets of patients with familial chordoma, those with and without a germline duplication of the T gene (T-dup+ vs T-dup-), which was previously identified as a susceptibility mechanism in some families. The authors then compared the patients with familial tumors to patients with sporadic chordoma in the US general population reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program through 2015.

Methods: Evaluation of family members included review of personal and family medical history, physical and neurological examination, and pre- and postcontrast MRI of the skull base and spine. Read More

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A Combined One-Staged Robot-Assisted Sacral Chordoma Resection.

World Neurosurg 2020 09 15;141:210-214. Epub 2020 Jun 15.

Department of Surgical and Biomedical Sciences, Urology Clinic Perugia-Terni, University of Perugia, Santa Maria della Misericordia Hospital Piazzale Menghini, Perugia, Italy.

Background: The robotic surgery is an advanced modern minimally invasive technology, widely used in urologic oncology, and it has become useful in particular conditions. Over time, different surgical specialties made use of the robotic properties to minimize complications for high-risk procedures. A combined 1-staged robot-assisted multidisciplinary surgery with intraoperative neurophysiological monitoring can be a safe procedure to remove a sacral chordoma with low morbidity rates. Read More

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September 2020

Skull Base Chordomas and Chondrosarcomas.

Neuroendocrinology 2020 15;110(9-10):836-847. Epub 2020 Jun 15.

Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany.

Skull base chordomas account for less than 0.2% and chondrosarcomas for less than 0.15% of all intracranial tumors. Read More

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LncRNA and mRNA expression profiles reveal the potential roles of lncRNA contributing to regulating dural penetration in clival chordoma.

Aging (Albany NY) 2020 06 13;12(11):10809-10826. Epub 2020 Jun 13.

Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China.

Chordoma is a rare bone cancer originating from embryologic notochordal remnants. Clival chordomas show different dural penetration ability, with serious dural penetration exhibiting poorer prognosis. The molecular mechanism of dural penetration is not clear. Read More

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[Clivus tumor. Metastasis vs. chordoma].

Medicina (B Aires) 2020 ;80(3):302

Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Argentina.

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February 2021

Clival Chordoma in an Adolescent: A Perspective from Primary Care.

Korean J Fam Med 2020 Nov 22;41(6):427-430. Epub 2020 May 22.

Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Malaysia.

Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache and blurring of vision, as well as a 6-month history of left-sided facial and body numbness. Read More

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November 2020

Experience With the Endoscopic Contralateral Transmaxillary Approach to the Petroclival Skull Base.

Laryngoscope 2021 02 15;131(2):294-298. Epub 2020 May 15.

Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Objectives/hypothesis: The contralateral transmaxillary (CTM) approach is a new surgical approach that improves the surgical trajectory relative to the petrous segment of the internal carotid artery (ICA). Here, we present our clinical experience with the CTM approach to the petroclival region of the skull base.

Study Design: Retrospective review. Read More

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February 2021

MRI Signal Intensity and Electron Ultrastructure Classification Predict the Long-Term Outcome of Skull Base Chordomas.

AJNR Am J Neuroradiol 2020 05 7;41(5):852-858. Epub 2020 May 7.

From the Department of Neurosurgery (J.B., P.Z., S. Geng, S. Gui, Y. Zhang), Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Background And Purpose: MR imaging is a useful and widely used evaluation for chordomas. Prior studies have classified chordomas into cell-dense type and matrix-rich type according to the ultrastructural features. However, the relationship between the MR imaging signal intensity and ultrastructural classification is unknown. Read More

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Chondromyxoid Fibroma of the Sacral Spine.

Int J Surg Pathol 2020 Oct 4;28(7):799-803. Epub 2020 May 4.

Rutgers New Jersey Medical School, Newark, NJ, USA.

. Chondromyxoid fibromas are rare tumors of cartilaginous origin typically found in long bones. They usually present during the second and third decades of life. Read More

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October 2020

Post-traumatic Sacral Epidermoid Cyst Masquerading as Chordoma on Imaging: A Case Report.

JNMA J Nepal Med Assoc 2020 Mar;58(223):192-194

Department of Critical Care Medicine, B & C Medical College Teaching Hospital & Research Center, Birtamode, Jhapa, Nepal.

Intradural spinal epidermoid cysts are rare, benign lesions either acquired from trauma, surgery, lumbar puncture or arise as congenital lesions, particularly associated with spinal dysraphism. Epidermoid cyst arising from the spine with expansile destruction of vertebrae has not been reported yet in the literature. We report a case of 36-years male presented with history of fall 8 years back with progressive symptoms of lower back pain, weakness of left lower limb and bladder/bowel incontinence. Read More

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Advances in the management of primary bone sarcomas of the skull base.

J Neurooncol 2020 Dec 18;150(3):393-403. Epub 2020 Apr 18.

Departments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Skull base primary malignancies represent a heterogeneous group of histologic diagnoses and sarcomas of the skull base are specific malignant tumors that arise from mesenchymal cells and can be classified by site of origin into bony and soft tissue sarcomas. The most common bony sarcomas include: chondrosarcoma, osteosarcoma, chordoma, Ewing's sarcoma. Given the relative rarity of each histologic diagnosis, especially in the skull base, there is limited published data to guide the management of patients with skull base sarcomas. Read More

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December 2020

Natural History of a Patient with Sacral Chordoma: Case Report and Literature Review.

World Neurosurg 2020 07 13;139:132-135. Epub 2020 Apr 13.

Division of Neurosurgery, Valleywise Health Medical Center, Creighton University School of Medicine, Phoenix, Arizona, USA; Department of Surgery, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona, USA. Electronic address:

Background: Chordomas are rare, slow-growing, locally aggressive, malignant tumors of the spine. Chordomas are conventionally treated with surgical resection with or without radiation. There is an absence of literature documenting the natural history of a primary sacral chordoma. Read More

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Unusual extradural chordoma in an adolescent presenting with lumbar radiculopathy.

BMJ Case Rep 2020 Apr 6;13(4). Epub 2020 Apr 6.

Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA

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Comparative proton versus photon treatment planning for the Medicare Medical Treatment Overseas Program: The Royal Adelaide Hospital experience.

J Med Imaging Radiat Oncol 2020 Oct 3;64(5):682-688. Epub 2020 Apr 3.

Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Introduction: Australia's first proton beam therapy (PBT) service, The Australian Bragg Centre for Proton Therapy and Research, is scheduled to open in the near future providing PBT for patients closer to home. Patients currently access Commonwealth funding for PBT via the Medicare Medical Treatment Overseas Program (MTOP). Proton versus photon treatment planning is a pre-requisite for the MTOP application. Read More

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October 2020

Expanded transnasal approaches to the skull base in the Middle East: Where do we stand?

Ann Saudi Med 2020 Mar-Apr;40(2):94-104. Epub 2020 Apr 2.

From the Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Endoscopic transnasal surgery has gained rapid global acceptance over the last two decades. The growing literature and understanding of anterior skull base endoscopic anatomy, in addition to new dedicated endoscopic instruments and tools, have helped to expand the use of the transnasal route in skull base surgery.

Objective: Report our early experience in expanded endoscopic transnasal surgery (EETS) and approach to skull base neoplasms. Read More

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December 2020

Salvage Free Tissue Transfer for Clival Osteoradionecrosis After Repeat Proton Beam Therapy.

World Neurosurg 2020 06 27;138:485-490. Epub 2020 Mar 27.

Department of Neurological Surgery, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

Background: Craniocervical junction chordoma treated with surgery and Proton Beam Therapy evolved with Osteonecrosis and CSF leak. As the vascularization of the head was compromised, we harvested an Anterolateral thigh musculofascial flap to seal the leak.

Case Description: A 56-year-old man presented with a history of chronic headaches and dysarthria with tongue deviation to the right. Read More

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Predictive role of Apparent Diffusion Coefficient (ADC) from Diffusion Weighted MRI in patients with sacral chordoma treated with carbon ion radiotherapy (CIRT) alone.

Eur J Radiol 2020 May 3;126:108933. Epub 2020 Mar 3.

Radiotherapy Unit, National Center of Oncology Hadrontherapy (CNAO), Pavia, Italy.

Purpose: To evaluate if baseline ADC from DWI sequences could predict response to treatment in patients with sacral chordoma not suitable for surgery treated with carbon ion radiotherapy (CIRT) alone compared with volume changes.

Methods: Fifty-nine patients with sacral chordoma not suitable for surgery underwent one cycle of CIRT alone and a minimum of 12-months follow-up. All patients underwent MRI before treatment (baseline), every three months in the first two years after treatment, and every six months afterwards. Read More

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Skull Base Parachordoma/Myoepithelioma.

J Int Adv Otol 2020 Aug;16(2):278-281

Department of ENT, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

Parachordoma is a rare soft tissue mixed tumor, associated with soft tissue myoepithelioma. It is typically growing slowly and considered less aggressive than other similar soft tissue tumors. However, it does recur sporadically, and on rare occasions, it has demonstrated the ability to metastasize. Read More

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Partial Sacrectomy for Resection of a Sacral Chordoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Sep;19(4):E412

Unidad de Patología Espinal, Hospital Español, Mendoza, Argentina.

Sacral chordomas are infrequent tumors that arise from remnants of the notochord. They are most often found in the sacrum and skull-base.1,2 These lesions rarely metastasize and usually have an indolent and oligosymptomatic clinical course. Read More

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September 2020

Total Penectomy for Recurrent Chordoma of the Corpus Cavernosum.

Case Rep Urol 2020 13;2020:5498069. Epub 2020 Feb 13.

Department of Urology, Ludwig-Maximilians-University, Munich, Germany.

Chordomas are rare low malignant neoplasm arising from remnants of the notochord with predilection site of the clivus or the os sacrum. Standard therapy is radical excision and adjuvant radiation. Due to invasive growth and adjacent to vital structures resection is often incomplete, and therefore, local recurrence is frequent. Read More

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February 2020

Chondrosarcoma of the dorsal spine - A rare case.

J Craniovertebr Junction Spine 2019 Oct-Dec;10(4):250-253. Epub 2020 Jan 23.

Department of Pathology, Seth GSMC, Mumbai, Maharashtra, India.

Chondrosarcomas of the spine are rare tumors and represent <10% of all chondrosarcomas. In the spine, they may arise from vertebral bodies or posterior elements. They may occur in patients ranging from 13 to 78 years of age. Read More

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January 2020