16,445 results match your criteria Image-guided Stellate Ganglion Blocks


[Clinical results of combined intracavitary-interstitial image-guided adaptive brachytherapy in locally advanced cervical cancer].

Magy Onkol 2018 Dec 10;62(4):249-257. Epub 2018 Aug 10.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

We present the early clinical results achieved with image-guided adaptive brachytherapy (IGABT) with combined intracavitary-interstitial (IC-IS) technique recently implemented in Hungary in the treatment of locally advanced cervical cancer (LACC). Twenty-one patients were treated with radio-chemotherapy (RCT) followed by combined IC-IS BT. At the end of the RCT we assessed the residual tumour with pelvic MRI. Read More

View Article
December 2018

[Dosimetric evaluation of intracavitary-interstitial image-guided adaptive brachytherapy of cervical cancer and comparison with conventional treatment techniques].

Magy Onkol 2018 Dec 31;62(4):242-248. Epub 2018 Aug 31.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

Our aim was the dosimetric evaluation of intracavitary-interstitial high-dose-rate image-guided adaptive cervix brachytherapy, implemented in Hungary. Between 2016 and 2018, 21 patients with cervical cancer were treated with overall 72 fractions. Graphical optimized treatment plans were compared to inverse optimized plans, 3D optimized plans (without needles) and conventional intracavitary 2D plans. Read More

View Article
December 2018

Clinical Outcomes Using a Novel Image-Guided Planning System in Patients With Cataract and IOL Implantation.

J Refract Surg 2018 Dec;34(12):824-831

Purpose: To determine the proportion of eyes with preexisting astigmatism achieving 0.50 diopters (D) or less of residual refractive cylinder 3 months after either implantation of toric intraocular lenses (IOLs) or corneal incisions using the VERION system (Alcon Laboratories, Inc., Fort Worth, TX) measurement module and digital markers for microscope (M) and laser (L). Read More

View Article
December 2018

Percutaneous microwave ablation of renal angiomyolipomas in tuberous sclerosis complex to improve the quality of life: preliminary experience in an Italian center.

Radiol Med 2018 Dec 11. Epub 2018 Dec 11.

Diagnostic and Interventional Radiology Department, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, Via A di Rudinì 8, 20142, Milan, Italy.

Aim: To evaluate efficacy, safety and quality of life of the patients with renal angiomyolipomas (AMLs) associated with tuberous sclerosis complex (TSC) treated with percutaneous microwave ablation (MWA).

Materials And Methods: Nine patients (7 females and 2 males; mean age 27.6 years, range 23-34), with 10 renal AMLs with a mean size of 6. Read More

View Article
December 2018

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

J Mol Med (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. Read More

View Article
December 2018

Performance of multiparametric MRI appears better when measured in patients who undergo radical prostatectomy.

Res Rep Urol 2018 22;10:233-235. Epub 2018 Nov 22.

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA,

Utilization of pre-biopsy multiparametric MRI (mpMRI) is increasing. To optimize the usefulness of mpMRI, physicians should accurately quote patients a numerical risk of cancer based on their MRI. The Prostate Imaging Reporting and Data System (PIRADS) standardizes interpretation of mpMRI; however, reported rates of clinically significant prostate cancer (CSC) stratified by PIRADS score vary widely. Read More

View Article
November 2018

An evaluation of the consistency of shifts reported by three different systems for non-coplanar treatments.

J Radiosurg SBRT 2018 ;5(4):323-330

Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84112, USA.

Treatment of intra-cranial lesions sometimes requires a non-coplanar beam configuration. One of the most commonly used IGRT modalities, kV conebeam CT, cannot typically be used when large couch rotations are introduced. However, multiple other systems allow for imaging/tracking the patient for such situations. Read More

View Article
January 2018

A Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior.

Int J Nanomedicine 2018 21;13:7801-7818. Epub 2018 Nov 21.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada,

Background: With the advances in radiopharmaceutical research, the development of image-guided therapy has become a major interest. While the development of theranostic nanotherapeutics is frequently associated with cancer chemotherapy, phototherapy and radiotherapy, there is little information available on the in vivo monitoring of gene delivery systems and the application of image-guided approach in gene therapy. The goal of this work was to determine the in vivo behavior of DNA delivery nanosystems - based on cationic gemini surfactants - designed for image-guided gene therapy. Read More

View Article
November 2018

Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.

J Control Release 2018 Dec 8. Epub 2018 Dec 8.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5, 8093 Zurich, Switzerland.

In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30-35%) with tumors exhibiting methylation of the promoter region of the O-methylguanine-DNA methyltransferase (MGMT) gene. In order to allow more patients to benefit from this treatment, we explored magnetic resonance image-guided microbubble-enhanced low-intensity pulsed focused ultrasound (LIFU) to transiently open the blood-brain barrier and deliver a first-in-class liposome-loaded small molecule MGMT inactivator in mice bearing temozolomide-resistant gliomas. We demonstrate that a liposomal O-(4-bromothenyl)guanine (OBTG) derivative can efficiently target MGMT, thereby sensitizing murine and human glioma cells to temozolomide in vitro. Read More

View Article
December 2018
7.705 Impact Factor

[Ultrasonography and image-guided injection techniques of the spinal column : Imaging is still the gold standard].

Authors:
F Faber

Schmerz 2018 Dec 10. Epub 2018 Dec 10.

Orthopädische Klinik, Universität Regensburg, Kaiser-Karl-V.-Allee 3, 93077, Bad Abbach, Deutschland.

View Article
December 2018

ARENA: Inter-modality affine registration using evolutionary strategy.

Int J Comput Assist Radiol Surg 2018 Dec 10. Epub 2018 Dec 10.

PERFORM Centre, Concordia University, Montreal, Canada.

Purpose: Image fusion of different imaging modalities renders valuable information to clinicians. In this paper, we proposed an automatic multimodal registration method to register intra-operative ultrasound images (US) to preoperative magnetic resonance images (MRI) in the context of image-guided neurosurgery.

Methods: We employed refined correlation ratio as a similarity metric for our intensity-based image registration method. Read More

View Article
December 2018

Problems and solutions in IGRT for cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):517-527. Epub 2018 May 26.

Centro Medico Imbanaco, Radiation Therapy Unit, Colombia.

The contribution of Image-guided Radiotherapy (IGRT) to modern radiotherapy is undeniable, being the way to bring into daily practice the dosimetric benefits of Intensity-Modulated Radiotherapy (IMRT). Organ and target motion is constant and unpredictable at the pelvis, thus posing a challenge to the safe execution of IMRT. There are potential benefits of IMRT in the radical treatment of cervical cancer patients, both in terms of dose escalation and decrease of toxicity. Read More

View Article

Image-guided brachytherapy in cervical cancer: Experience in the Complejo Hospitalario de Navarra.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):510-516. Epub 2018 Oct 19.

Department of Radiation Oncology, Hospital de Navarra, Pamplona, Spain.

Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma.

Material And Methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Read More

View Article
October 2018

Stereotactic Pelvic Navigation With Augmented Reality for Transanal Total Mesorectal Excision.

Dis Colon Rectum 2019 Jan;62(1):123-129

IHU-Strasbourg, Institute for Image-Guided Surgery, Strasbourg, France.

Introduction: Technical difficulty and unfamiliar surgical anatomy are the main challenges in transanal total mesorectal excision. Precise 3-dimensional real-time image guidance may facilitate the safety, accuracy, and efficiency of transanal total mesorectal excision.

Technique: A preoperative CT was obtained with 10 skin fiducials and further processed to emphasize the border of the anatomical structure by 3-dimensional modeling and pelvic organ segmentation. Read More

View Article
January 2019
2 Reads

Nodal volume as a prognostic factor in locally advanced head and neck cancer: Identifying candidates for elective neck dissection after chemoradiation with IGRT from a single institutional prospective series from the Indian subcontinent.

Oral Oncol 2018 Dec;87:179-185

Department of Radiotherapy, Batra Hospital, Tughlakabad Institutional Area, Mehrauli Badarpur Road, Near Saket Metro Station, New Delhi, Delhi 110062, India.

Objective: Nodal volume as a prognostic factor has been extensively evaluated in head and neck cancer, however there is still no consensus. We attempted to analyze nodal volume as a prognostic factor in head and neck cancer treated with chemoradiation (CCRT) without an elective neck dissection with image guided intensity modulated radiotherapy (IG-IMRT).

Material And Methods: We prospectively analysed 87 patients of Stage III-IV cancer of the oropharynx (57), and hypopharynx (30), who subsequently received definitive concurrent chemoradiation. Read More

View Article
December 2018

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.

Lung Cancer 2018 Dec 5;126:139-148. Epub 2018 Nov 5.

National Korányi Institute of Pulmonology, Budapest, Hungary. Electronic address:

Introduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed.

Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression. Read More

View Article
December 2018

SBRT targets that move with respiration.

Phys Med 2018 Dec 17;56:19-24. Epub 2018 Nov 17.

Royal North Shore Hospital, Australia.

The technology of treating SBRT targets that move with respiration has undergone profound changes over the last 20 years. This review article summarizes modern image guidance to localize the target in real-time to account for intra-fraction motion. The state-of-the art respiratory motion compensation techniques will be discussed, including the determination and application of appropriate margins. Read More

View Article
December 2018

[CT-guidance interstitial Iodine-125 seed brachytherapy as a salvage therapy for recurrent head and neck carcinoma].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3686-3691

Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.

To investigate the efficacy of CT-guidance interstitial Iodine-125 seed brachytherapy as a salvage therapy for recurrent head and neck carcinoma. A total of 122 patients who had been treated for recurrent head and neck carcinoma with CT-guided Iodine-125 seed permanent implantation were conducted a retrospective analysis at Peking University Third Hospital from February 2003 to December 2015. The study included 78 male and 44 female patients. Read More

View Article
December 2018

Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation.

Int J Radiat Biol 2018 Dec 7:1-43. Epub 2018 Dec 7.

a Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy.

Purpose: Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. Read More

View Article
December 2018

Static Lateral Tibial Plateau Subluxation Predicts High-Grade Rotatory Knee Laxity in Anterior Cruciate Ligament-Deficient Knees.

Am J Sports Med 2018 Dec 7:363546518812435. Epub 2018 Dec 7.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background:: In anterior cruciate ligament-deficient (ACL-D) knees, injury pattern and bony morphologic features have been shown to influence both static anterior tibial subluxation relative to the femur and dynamic rotatory knee laxity. Therefore, the relationship between static anterior tibial subluxation and dynamic rotatory knee laxity was investigated.

Purpose:: To determine whether static tibial subluxation as measured on magnetic resonance imaging (MRI) is associated with the grade of rotatory knee laxity in ACL-D knees. Read More

View Article
December 2018

Percutaneous drainage and management of fluid collections associated with necrotic or cystic tumors in the abdomen and pelvis.

Abdom Radiol (NY) 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Louisiana State University Health, Shreveport, LA, USA.

Purpose: The purpose of the study was to evaluate the efficacy and safety of percutaneous drainage for palliation of symptoms and sepsis in patients with cystic or necrotic tumors in the abdomen and pelvis.

Materials And Methods: This is a single center retrospective study of 36 patients (18 men, mean age = 51.1 years) who underwent percutaneous drainage for management of cystic or necrotic tumors in the non-postoperative setting over an 11-year period. Read More

View Article
November 2018

Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Breast Cancer Res Treat 2018 Nov 30. Epub 2018 Nov 30.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland Schmelzbergstrasse 12., 8091, Zurich, Switzerland.

Purpose: The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations.

Methods: This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy.

Results: In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years. Read More

View Article
November 2018
1 Read

Type II endoleak model creation and intraoperative aneurysmal sac embolization with -butyl cyanoacrylate-lipiodol-ethanol mixture (NLE) in swine.

Quant Imaging Med Surg 2018 Oct;8(9):894-901

Department of Radiology, Wakayama Medical University, Wakayama, Japan.

Background: The purpose of this study was to evaluate the feasibility of type II endoleak model creation and efficacy of intraoperative aneurysmal sac embolization using -butyl-2-cyanoacrylate-lipiodol-ethanol mixture (NLE) for type II endoleak in swine.

Methods: In six swine (mean body weight 53.5 kg), abdominal aortic aneurysm (AAA) was created and then end-to-side anastomosis between the left renal artery and AAA sac was performed. Read More

View Article
October 2018

Adjuvant gamma knife surgery and image-guided, intensity-modulated radiation therapy for the treatment of sacral chordomas.

Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):74-79. Epub 2018 Nov 22.

Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

Aim: The aim of this study was to confirm whether patients with sacral chordoma benefit from adjuvant radiotherapy and to determine the optimal photon radiotherapy module for comprehensive treatment.

Background: Chordoma is a rare slow-growing neoplasm arisen from cellular remnants of the notochord. About 50% occur in the sacrococcygeal region. Read More

View Article
November 2018

Three dimensional tumor-margin demarcation using the hybrid tracer indocyanine green-Tc-nanocolloid, a proof of concept study in tongue cancer patients scheduled for sentinel node biopsy.

J Nucl Med 2018 Nov 30. Epub 2018 Nov 30.

Leiden University Medical Center, Netherlands.

For radical resection of squamous cell carcinoma of the oral cavity, a tumor free margin of at least 5 mm is required. Unfortunately, establishing in-depth margins is a surgical conundrum. Knowing the hybrid sentinel node (SN) tracer indocyanine green (ICG)-Tc-nanocolloid generates temporary tattoo-like markings at the site of administration, we studied the ability of applying this tracer for tumor-margin demarcation combined with SN biopsy. Read More

View Article
November 2018
1 Read

Anterior mediastinal masses - A multidisciplinary pathway for safe diagnostic procedures.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, St Georges Hospital NHS Trust, London, UK. Electronic address:

Objective: The objective of this study was to report our multidisciplinary diagnostic approach for patients with anterior mediastinal masses (AMM).

Methods: A retrospective review of patients with AMM at a tertiary pediatric surgical oncology centre (January 2011-December 2016) was performed. We analyzed data on clinical presentation, mode of tissue diagnosis, anesthetic techniques, and complications. Read More

View Article
November 2018
3 Reads

Near-infrared Fluorescent Peptides with High Tumor Selectivity: Novel Probes for Image-Guided Surgical Resection of Orthotopic Glioma.

Mol Pharm 2018 Dec 5. Epub 2018 Dec 5.

The complete excision of glioblastomas with maximal retention of surrounding normal tissues can significantly improve patient prognosis. Near-infrared fluorescence (NIRF) optical imaging of the tumor vasculature offers a non-invasive method for detection of early-stage glioblastoma and efficient monitoring of therapeutic responses. The aim of this study was to develop a novel NIRF imaging probe as a visualization tool for image-guided surgical resection of orthotopic glioblastoma. Read More

View Article
December 2018
1 Read

Image-Guided Neutron Capture Therapy Using the Gd-DO3A-BTA Complex as a New Combinatorial Treatment Approach.

Contrast Media Mol Imaging 2018 1;2018:3727109. Epub 2018 Nov 1.

Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 700-721, Republic of Korea.

Gadolinium-neutron capture therapy (Gd-NCT) is based on the nuclear capture reaction that occurs when Gd is irradiated with low energy thermal neutrons to primarily produce gamma photons. Herein, we investigated the effect of neutron capture therapy (NCT) using a small molecular gadolinium complex, Gd-DO3A-benzothiazole (Gd-DO3A-BTA), which could be a good candidate for use as an NCT drug due to its ability to enter the intracellular nuclei of tumor cells. Furthermore, MRI images of Gd-DO3A-BTA showed a clear signal enhancement in the tumor, and the images also played a key role in planning NCT by providing accurate information on the uptake time and duration of Gd-DO3A-BTA. Read More

View Article
November 2018
1 Read
2.923 Impact Factor

[Accuracy of different image registration methods in image-guided adaptive brachytherapy for cervical cancer].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1344-1348

School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.

Objective: To compare the accuracy of different methods for image registration in image-guided adaptive brachytherapy (IGABT) for cervical cancer.

Methods: The last treatment planning CT images (CT1) and the first treatment planning CT images (CT2) were acquired from 15 patients with cervical cancer and registered with different match image qualities (retained/removed catheter source in images) and different match regions [target only (S Group)/ interested organ structure (M Group)/body (L Group)] in Velocity3.2 software. Read More

View Article
November 2018

Impact of prebiopsy magnetic resonance imaging of the prostate on cancer detection and treatment patterns.

Urol Oncol 2018 Dec 1. Epub 2018 Dec 1.

Emory University Department of Urology, Emory University School of Medicine, Atlanta, GA; Emory University Winship Cancer Institute, Atlanta, GA; Atlanta Veterans Administration Medical Center, Decatur, GA. Electronic address:

Purpose: Though superior in clinical trial settings, outcomes following magnetic resonance image (MRI)-guided prostate biopsies have not been reported broadly. We compared prostate cancer detection rates for men who did and did not undergo prebiopsy MRI and evaluated treatment patterns based on biopsy approach, year of biopsy, and proximity to early adopters.

Methods: Using private insurance claims (2009-2015), we identified men who underwent prostate biopsy using appropriate procedure codes. Read More

View Article
December 2018
1 Read

Localized pancreatic Castleman disease presenting with extrahepatic dilatation of bile ducts: A case report and review of published cases.

Int J Surg Case Rep 2018 Nov 20;54:28-33. Epub 2018 Nov 20.

Universidade Federal do Vale do São Francisco, Av. José de Sá Maniçoba, S/N - Centro, CEP: 56304-917, Petrolina, PE, Brazil. Electronic address:

Introduction: Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder of unknown etiology, which usually develops in the mediastinum. It can also occur in the cervical, retroperitoneal and axillary regions. Localized pancreatic CD is quite rare [1]. Read More

View Article
November 2018
1 Read

Augmented visualization with depth perception cues to improve the surgeon's performance in minimally invasive surgery.

Med Biol Eng Comput 2018 Dec 4. Epub 2018 Dec 4.

Department of Engineering for Innovation, University of Salento, Lecce, Italy.

Minimally invasive techniques, such as laparoscopy and radiofrequency ablation of tumors, bring important advantages in surgery: by minimizing incisions on the patient's body, they can reduce the hospitalization period and the risk of postoperative complications. Unfortunately, they come with drawbacks for surgeons, who have a restricted vision of the operation area through an indirect access and 2D images provided by a camera inserted in the body. Augmented reality provides an "X-ray vision" of the patient anatomy thanks to the visualization of the internal organs of the patient. Read More

View Article
December 2018

Fast quantitative reconstruction with focusing collimators for liver SPECT.

EJNMMI Phys 2018 Dec 4;5(1):28. Epub 2018 Dec 4.

Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508, Utrecht, GA, Netherlands.

Background: Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and fast quantitative reconstruction. Focusing collimators increase sensitivity and thus may speed up imaging. Read More

View Article
December 2018

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer.

Am J Nucl Med Mol Imaging 2018 20;8(5):282-291. Epub 2018 Oct 20.

Department of Surgery, Leiden University Medical Center Leiden, The Netherlands.

cRGD peptides target integrins associated with angiogenesis (e.g., αβ) and cancer, and have been used as binding ligands for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) optical imaging. Read More

View Article
October 2018

Fluorescence image-guided lymphadenectomy using indocyanine green and near infrared technology in robotic gastrectomy.

Chin J Cancer Res 2018 Oct;30(5):568-570

Department of Surgical Sciences, "La Sapienza" University of Rome, Rome 00161, Italy.

In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called " navigation surgery". Among the different reported solutions, the introduction of the indocyanine green (ICG) has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band (NIR). A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization. Read More

View Article
October 2018
6 Reads

Case series on multiple prostate re-irradiation for locally recurrent prostate cancer: something ventured, something gained.

Neoplasma 2018 Nov 25. Epub 2018 Nov 25.

Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.

The aim is to present the technical feasibility and efficacy of multiple re-irradiation (re-EBRT) for local recurrence of prostate cancer (PCa) using retrospective analysis of an updated series of patients who received ablative re-EBRT with stereotactic image-guided technique for isolated local recurrence of PCa. Eight patients received three RT courses (2 re-RTs); of those 2 received 4 RT courses (3 re-RTs). Local relapse in the prostate was assessed by multiparametric magnetic resonance and/ or choline positron emission tomography. Read More

View Article
November 2018

Prognostic factors for local recurrence in extremity-located giant cell tumours of bone with pathological fracture.

Bone Joint J 2018 Dec;100-B(12):1626-1632

Royal Orthopaedic Hospital, Birmingham, UK.

Aims: The aim of this paper was to investigate the prognostic factors for local recurrence in patients with pathological fracture through giant cell tumours of bone (GCTB).

Patients And Methods: A total of 107 patients presenting with fractures through GCTB treated at our institution (Royal Orthopaedic Hospital, Birmingham, United Kingdom) between 1995 and 2016 were retrospectively studied. Of these patients, 57 were female (53%) and 50 were male (47%). Read More

View Article
December 2018
1 Read

Mitochondria-Targeting Identification of a Fluorescent Apoptosis-Triggering Molecule by Mass Spectrometry Unravels Drug Tracking.

Chembiochem 2018 Nov 30. Epub 2018 Nov 30.

CHINA.

The real-time tracking of localization and dynamics of small molecules in organelles helps to understand their function and lock their potential targets at the subcellular resolution. To identify the mitochondria-targeting effect of small molecules (NA-17 and NA-2a) in cancer cells, we used mass spectrometry to study the distribution and enrichment of small molecules in mitochondria and the residual cytoplasm, which enables to trace action process of therapeutic molecules. Colocalization analysis with an image-guided way suggests that both NA-17 and NA-2a have mitochondria-targeting effect. Read More

View Article
November 2018

Which method of distal pancreatectomy is cost-effective among open, laparoscopic, or robotic surgery?

Hepatobiliary Surg Nutr 2018 Oct;7(5):345-352

General, Digestive, and Endocrine Surgery, Nouvel Hôpital Civil, Strasbourg, France.

Background: The aim of this study was to analyze the clinical and economic impact of robotic distal pancreatectomy, laparoscopic distal pancreatectomy, and open distal pancreatectomy.

Methods: All consecutive patients who underwent distal pancreatic resection for benign and malignant diseases between January 2012 and December 2015 were prospectively included. Cost analysis was performed; all charges from patient admission to discharge were considered. Read More

View Article
October 2018
4 Reads

Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision.

Breast Care (Basel) 2018 Oct 13;13(5):364-368. Epub 2018 Jul 13.

Institute of Radiology (RZI), Klinikum Frankfurt Höchst, Academic Teaching Hospital of the University of Frankfurt, Frankfurt/M., Germany.

Background: The management of intraductal papilloma without atypia (IDP) in breast needle biopsy remains controversial. This study investigates the upgrade rate of IDP to carcinoma and clinical and radiologic features predictive of an upgrade.

Methods: Patients with a diagnosis of IDP on image-guided (mammography, ultrasound, magnetic resonance imaging) core needle or vacuum-assisted biopsy and surgical excision of this lesion at a certified breast center between 2007 and 2017 were included in this institutional review board-approved retrospective study. Read More

View Article
October 2018

Medical Student Ultrasound Education: A WFUMB Position Paper, Part I.

Ultrasound Med Biol 2018 Nov 27. Epub 2018 Nov 27.

University of South Carolina School of Medicine, Department of Emergency Medicine, St. Francis Hospital, Columbus Georgia, USA.

The introduction of ultrasound into medical student education is well underway in many locations around the world, but is still in its infancy or has yet to begin in others. Proper incorporation of ultrasound education into medical training requires planning and resources, both capital and human. In this article, we discuss the state of the art of ultrasound in medical education throughout the world, as well as various methodologies utilized to improve student education and to incorporate ultrasound into every facet of training. Read More

View Article
November 2018
3 Reads

Role of PET imaging in adaptive radiotherapy for lymphoma.

Q J Nucl Med Mol Imaging 2018 Dec;62(4):411-419

Guy's Cancer Centre, Guy's & St Thomas' NHS Trust, London, UK.

Positron emission tomography/Computed tomography (PET/CT) is an essential part of modern radiotherapy for patients with lymphoma. PET/CT can be used to adapt treatment algorithms in Hodgkin lymphoma, reserving consolidation radiotherapy for patients with residual fluoro-D-glucose (FDG) avidity after treatment with intensive chemotherapy such as escalated BEACOPP and limiting the need for radiotherapy for some patients with complete metabolic response on PET if radiotherapy may be associated with increased toxicity. More importantly, PET/CT is now mandatory to define sites of initial disease for radiotherapy planning where smaller volumes are to be used rather than historical extended field treatments, such as mantle radiotherapy or even involved field radiotherapy. Read More

View Article
December 2018
2 Reads

Molecular PET imaging in adaptive radiotherapy: brain.

Q J Nucl Med Mol Imaging 2018 Dec;62(4):337-348

Department of Radiation Therapy, Claudius Regaud Institute, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France -

Introduction: Owing to their heterogeneity and radioresistance, the prognosis of primitive brain tumors, which are mainly glial tumors, remains poor. Dose escalation in radioresistant areas is a potential issue for improving local control and overall survival. This review focuses on advances in biological and metabolic imaging of brain tumors that are proving to be essential for defining tumor target volumes in radiation therapy (RT) and for increasing the use of DPRT (dose painting RT) and ART (adaptative RT), to optimize dose in radio-resistant areas. Read More

View Article
December 2018
1 Read

Chronic rupture of the left ventricular wall with a giant pseudoaneurysm.

Eur Heart J Cardiovasc Imaging 2018 Nov 27. Epub 2018 Nov 27.

Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.

View Article
November 2018
3 Reads

High correlation of temporal muscle thickness with lumbar skeletal muscle cross-sectional area in patients with brain metastases.

PLoS One 2018 29;13(11):e0207849. Epub 2018 Nov 29.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objectives: This study aimed to assess the correlation of temporal muscle thickness (TMT), measured on routine cranial magnetic resonance (MR) images, with lumbar skeletal muscles obtained on computed tomography (CT) images in brain metastasis patients to establish a new parameter estimating skeletal muscle mass on brain MR images.

Methods: We retrospectively analyzed the cross-sectional area (CSA) of skeletal muscles at the level of the third lumbar vertebra on computed tomography scans and correlated these values with TMT on MR images of the brain in two independent cohorts of 93 lung cancer and 61 melanoma patients (overall: 154 patients) with brain metastases.

Results: Pearson correlation revealed a strong association between mean TMT and CSA in lung cancer and melanoma patients with brain metastases (0. Read More

View Article
November 2018
2 Reads

Reply: Evaluation and Implementation of a High-Fidelity Cleft Palate Simulator.

Plast Reconstr Surg 2018 Dec;142(6):980e-981e

Division of Plastic and Reconstructive Surgery, University of Toronto, Toronto, Ontario, Center for Image Guided Innovation and Therapeutic Intervention, Toronto, Ontario Division of Plastic and Reconstructive Surgery, Vancouver Island Health Authority, Victoria, British Columbia Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario Center for Image Guided Innovation and Therapeutic Intervention, Toronto, Ontario, Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article
December 2018

Image-Guided Percutaneous Bleomycin and Bevacizumab Sclerotherapy of Orbital Lymphatic Malformations in Children.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Cairo University Hospitals, Cairo, Egypt.

Purpose: To evaluate the effectiveness and safety of image-guided percutaneous sclerotherapy using bleomycin for macrocystic and bevacizumab (Avastin™) for microcystic orbital lymphatic malformations in children.

Materials And Methods: Between October 2015 and July 2018, we prospectively evaluated 10 pediatric patients who presented clinically and radiologically with lymphatic malformations and were treated with percutaneous sclerotherapy. Patients with venous malformations were excluded. Read More

View Article
November 2018

Radioablation by Image-Guided (HDR) Brachytherapy and Transarterial Chemoembolization in Hepatocellular Carcinoma: A Randomized Phase II Trial.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology, Luwig-Maximilians-University Munich, Munich, Germany.

Background And Aims: The aim of this single-center, open-label phase II study was to assess the efficacy of image-guided high-dose-rate (HDR) brachytherapy (iBT) compared with conventional transarterial embolization (cTACE) in unresectable hepatocellular carcinoma.

Methods: Seventy-seven patients were treated after randomization to iBT or cTACE, as single or repeated interventions. Crossover was allowed if clinically indicated. Read More

View Article
November 2018
1.965 Impact Factor

Comparability of dental implant site ridge measurements using ultra-low-dose multidetector row computed tomography combined with filtered back-projection, adaptive statistical iterative reconstruction, and model-based iterative reconstruction.

Oral Radiol 2018 Oct 13. Epub 2018 Oct 13.

Department of Radiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.

Objective: To assess the linear measurements of edentulous ridges recorded from multidetector row computed tomography (MDCT) images obtained by a previously untested ultra-low dose in combination with filtered back-projection (FBP), adaptive statistical iterative reconstruction (ASIR), and model-based iterative reconstruction (MBIR).

Methods: Three cadavers were imaged using a reference protocol with a standard dose and FBP (volume CT dose index (CTDIvol): 29.4 mGy) and two ultra-low-dose protocols, LD1 and LD2 (CTDIvol: 0. Read More

View Article
October 2018
1 Read

Iterative simulations to estimate the elastic properties from a series of MRI images followed by MRI-US validation.

Med Biol Eng Comput 2018 Nov 27. Epub 2018 Nov 27.

Universitá di Verona, Strada le Grazie 15, 37134, Verona, Italy.

The modeling of breast deformations is of interest in medical applications such as image-guided biopsy, or image registration for diagnostic purposes. In order to have such information, it is needed to extract the mechanical properties of the tissues. In this work, we propose an iterative technique based on finite element analysis that estimates the elastic modulus of realistic breast phantoms, starting from MRI images acquired in different positions (prone and supine), when deformed only by the gravity force. Read More

View Article
November 2018