75,732 results match your criteria Image-Guided Surgery

Aggregation-induced Emission (AIE) and Magnetic Resonance Imaging Characteristics for Targeted and Image-guided siRNA Therapy of Hepatocellular Carcinoma.

Adv Healthc Mater 2022 Jun 24:e2200579. Epub 2022 Jun 24.

Shanghai Institute of Transplantation, Shanghai, 200127, China.

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains a global health challenge. Small interfering RNA (siRNA) is a promising therapeutic modality that blocks multiple disease-causing genes without impairing cell structures. However, siRNA therapeutics still have off-target proportion and lack effective quantitative analysis method in vivo. Read More

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Accuracy Assessment of Percutaneous Pedicle Screw Placement Using Cone Beam Computed Tomography with Metal Artifact Reduction.

Sensors (Basel) 2022 Jun 18;22(12). Epub 2022 Jun 18.

Department of Interventional Radiology, University Hospital of Strasbourg, 67000 Strasbourg, France.

Metal artifact reduction (MAR) algorithms are used with cone beam computed tomography (CBCT) during augmented reality surgical navigation for minimally invasive pedicle screw instrumentation. The aim of this study was to assess intra- and inter-observer reliability of pedicle screw placement and to compare the perception of baseline image quality (NoMAR) with optimized image quality (MAR). CBCT images of 24 patients operated on for degenerative spondylolisthesis using minimally invasive lumbar fusion were analyzed retrospectively. Read More

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A Smarter Health through the Internet of Surgical Things.

Sensors (Basel) 2022 Jun 17;22(12). Epub 2022 Jun 17.

Intelligent Systems Lab, Department of Cultural Technology and Communication, University of the Aegean, 81100 Mytilene, Greece.

(1) Background: In the last few years, technological developments in the surgical field have been rapid and are continuously evolving. One of the most revolutionizing breakthroughs was the introduction of the IoT concept within surgical practice. Our systematic review aims to summarize the most important studies evaluating the IoT concept within surgical practice, focusing on Telesurgery and surgical Telementoring. Read More

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Three-Dimensional Planning and Patient-Specific Instrumentation for the Fixation of Distal Radius Fractures.

Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Department of Hand Surgery, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.

: Three-dimensional planning and guided osteotomy utilizing patient-specific instrumentation (PSI) with the contralateral side used as a reference have been proven as effective in the treatment of malunions following complex fractures of the distal radius. However, this approach has not yet been described in relation to fracture reduction of the distal radius. The aim of this study was to assess the technical and logistical feasibility of computer-assisted surgery in a clinical setting using PSI for fracture reduction and fixation. Read More

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Correlation of Tumor Pathology with Fluorescein Uptake and MRI Contrast-Enhancement in Stereotactic Biopsies.

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.

The utilization of fluorescein-guided biopsies has recently been discussed to improve and expedite operative techniques in the detection of tumor-positive tissue, as well as to avoid making sampling errors. In this study, we aimed to report our experience with fluorescein-guided biopsies and elucidate distribution patterns in different histopathological diagnoses in order to develop strategies to increase the efficiency and accuracy of this technique. We report on 45 fluorescence-guided stereotactic biopsies in 44 patients (15 female, 29 male) at our institution from March 2016 to March 2021, including 25 frame-based stereotactic biopsies and 20 frameless image-guided biopsies using VarioGuide. Read More

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A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer.

Cancers (Basel) 2022 Jun 12;14(12). Epub 2022 Jun 12.

NMI Natural and Medical Sciences Institute, The University of Tuebingen, 72770 Reutlingen, Germany.

In light of the frequent development of therapeutic resistance in cancer treatment, there is a strong need for personalized model systems representing patient tumor heterogeneity, while enabling parallel drug testing and identification of appropriate treatment responses in individual patients. Using ovarian cancer as a prime example of a heterogeneous tumor disease, we developed a 3D preclinical tumor model comprised of patient-derived microtumors (PDM) and autologous tumor-infiltrating lymphocytes (TILs) to identify individual treatment vulnerabilities and validate chemo-, immuno- and targeted therapy efficacies. Enzymatic digestion of primary ovarian cancer tissue and cultivation in defined serum-free media allowed rapid and efficient recovery of PDM, while preserving histopathological features of corresponding patient tumor tissue. Read More

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Nanoparticle-assisted, image-guided laser interstitial thermal therapy for cancer treatment.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2022 Jun 23:e1826. Epub 2022 Jun 23.

Fischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland, USA.

Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non-central nervous system (non-CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real-time monitoring and assessment of thermal doses during the procedure. Despite promising clinical results, LITT complications relating to brain tumor procedures, such as hemorrhage, edema, seizures, and thermal injury to nearby healthy tissues, remain a significant concern. Read More

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Multimodality Image-Guided Embolization of Bronchial Artery Pseudoaneurysm in a Patient With Aortopathy.

JACC Case Rep 2022 Jun 15;4(12):721-726. Epub 2022 Jun 15.

Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, USA.

A 59-year-old man received an incidental diagnosis of a 5-cm right para-aortic mass that was initially thought to be of venous origin. Multimodality imaging revealed a right bronchial artery pseudoaneurysm that was treated with endovascular embolization. Bronchial artery pseudoaneurysms are extremely rare and can be fatal if ruptured. Read More

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Single-stage cranioplasty with customized polyetheretherketone implant after tumor resection using virtual reality and augmented reality for precise implant customization and placement: illustrative case.

J Neurosurg Case Lessons 2022 May 23;3(21):CASE2255. Epub 2022 May 23.

Division of Neurosurgery, Department of Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania; and.

Background: Cranioplasties are routinely performed to restore cosmesis and to protect intracranial contents after trauma, resection of tumors, or other pathologies. Traditionally done as a second-stage procedure, new single-stage cranioplasty protocols have been developed to minimize recovery periods, decrease complications, and improve patient satisfaction. These protocols, however, still require the use of larger than planned implants or use larger than ideal incisions to accommodate three-dimensional (3D) templates, which may not be optimal in regions with complex bony anatomy. Read More

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Computer-assisted and navigated piezoelectric surgery: A new technology to improve precision and surgical safety in craniomaxillofacial surgery.

Laryngoscope Investig Otolaryngol 2022 Jun 5;7(3):684-691. Epub 2022 Apr 5.

Department of Oral and Maxillofacial Surgery Reina Sofía University Hospital Córdoba Spain.

Background: Computer-assisted navigated piezoelectric surgery (CANPS) is a surgical technique that combines the surgical navigation with a piezoelectric device. This association multiplies the advantages of both technologies, taking the best of each one providing a synergistic association.

Objective: To describe and assess the indications, advantages, disadvantages, and complications of this association of surgical techniques. Read More

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Gradual Deformity Correction with a Computer-assisted Hexapod External Fixator in Blount's Disease.

Strategies Trauma Limb Reconstr 2022 Jan-Apr;17(1):32-37

Department of Orthopaedic Surgery, University of KwaZulu-Natal, Durban, South Africa.

Aim: To evaluate the results in terms of correction and complications from gradual correction with a computer-assisted hexapod circular external fixator in a mixed cohort of children with Blount's disease.

Materials And Methods: A retrospective review was performed of the correction and complications of 19 children (25 limbs) with recurrent infantile (IBD) and late-onset Blount's disease (LOBD) treated by gradual correction with a hexapod external fixator. The correction was measured by the medial proximal tibial angle (MPTA), anatomic posterior proximal tibial angle (aPPTA) and anatomic tibio-femoral angle (TFA). Read More

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Endoscopic endonasal approach for simultaneously treating a pituitary adenoma coexisting with a paraclinoid aneurysm: illustrative case.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE22130. Epub 2022 Jun 20.

Department of Neurosurgery, Yongzhou Central Hospital, Yongzhou City, Hunan Province, People's Republic of China.

Background: There is a certain incidence of pituitary adenomas coexisting with intracranial aneurysms, but a concurrent therapeutic strategy of tumor removal and aneurysm clipping via endoscopic endonasal approach is rarely reported. The indications and limitations of endoscopic endonasal approach surgery for this type of lesions are worth discussing.

Observations: The case of a pituitary tumor coexisting with a paraclinoid aneurysm was reviewed. Read More

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Augmented reality-assisted microsurgical resection of brain arteriovenous malformations: illustrative case.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE21135. Epub 2022 Jun 20.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York; and.

Background: Arteriovenous malformations (AVMs) of the brain are vessel conglomerates of feeding arteries and draining veins that carry a risk of spontaneous and intraoperative rupture. Augmented reality (AR)-assisted neuronavigation permits continuous, real-time, updated visualization of navigation information through a heads-up display, thereby potentially improving the safety of surgical resection of AVMs.

Observations: The authors report a case of a 37-year-old female presenting with a 2-year history of recurrent falls due to intermittent right-sided weakness and increasing clumsiness in the right upper extremity. Read More

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Use of virtual magnetic resonance imaging to compensate for brain shift during image-guided surgery: illustrative case.

J Neurosurg Case Lessons 2022 Jun 13;3(24):CASE21683. Epub 2022 Jun 13.

Department of Neurosurgery, University of South Florida, Tampa, Florida; and.

Background: Maximal safe resection is the paramount objective in the surgical management of malignant brain tumors. It is facilitated through use of image-guided neuronavigation. Intraoperative image guidance systems use preoperative magnetic resonance imaging (MRI) as the navigational map. Read More

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Protocol for live cell image segmentation to profile cellular morphodynamics using MARS-Net.

STAR Protoc 2022 Sep 14;3(3):101469. Epub 2022 Jun 14.

Vascular Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.

Quantitative studies of cellular morphodynamics rely on accurate cell segmentation in live cell images. However, fluorescence and phase contrast imaging hinder accurate edge localization. To address this challenge, we developed MARS-Net, a deep learning model integrating ImageNet-pretrained VGG19 encoder and U-Net decoder trained on the datasets from multiple types of microscopy images. Read More

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September 2022

Therapeutic Use of Robotic Bronchoscopy System to Treat Chronic Invasive Pulmonary Aspergillosis.

J Bronchology Interv Pulmonol 2022 07 22;29(3):e35-e38. Epub 2022 Jun 22.

Section of Interventional Pulmonary Division of Pulmonary, Critical Care Allergy and Sleep Medicine, University of California San Francisco, San Francisco.

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Synchronous resection of 12 small pulmonary nodules guided by a noninvasive 3D printed emulation model: A case report.

Thorac Cancer 2022 Jun 21. Epub 2022 Jun 21.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Localization of multiple small pulmonary nodules is the major obstacle in surgical resection. Here, we report a novel noninvasive localization technique based on a life-size 3D printed "emulation pulmonary nodule localization model" which is simple and efficient. In the case reported here of a patient with synchronous multiple pulmonary nodules, the nodules were successfully and conveniently localized without any trauma by navigation of the emulation localization model. Read More

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Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis.

BMC Cancer 2022 Jun 21;22(1):682. Epub 2022 Jun 21.

Department of Radiation Oncology, University Hospital of Freiburg, Robert-Koch-Strasse 3, 79106, Freiburg, Germany.

Background: Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomical organ movement in deep inspiration also cause unintended exposure of locoregional lymph nodes to the irradiation field.

Methods: From 2017-2020, 148 patients with left-sided breast cancer underwent breast conserving surgery (BCS) or mastectomy (ME) with axillary lymph node staging, followed by adjuvant irradiation in DIBH technique. Read More

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[Robotic-assisted Thoracic Surgery].

Anasthesiol Intensivmed Notfallmed Schmerzther 2022 Jun 21;57(6):394-404. Epub 2022 Jun 21.

In the last decade robotic-assisted thoracoscopic surgery (RATS) emerged as a new minimally invasive surgical modality to operate pulmonary, mediastinal and esophageal diseases. Superior to video-assisted thoracoscopic surgery (VATS), RATS affords accurate surgical manipulation in spatially confined anatomical regions. Numerous surgical case studies demonstrated technical reliability and oncological equivalence of RATS compared to open surgery and VATS. Read More

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Adverse Events Associated With Image-Guided Sinus Navigation in Endoscopic Sinus Surgery: A MAUDE Database Analysis.

Otolaryngol Head Neck Surg 2022 Jun 21:1945998221107547. Epub 2022 Jun 21.

Tina and Rick Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Objective: The utilization of image-guided navigation during endoscopic sinus surgery (ESS) has increased significantly since its introduction. However, the most common associated complications are still unknown. This study describes and analyzes adverse events related to image-guided ESS. Read More

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Accuracy of Guided Implant Surgery Using an Intraoral Scanner and Desktop 3D-Printed Tooth-Supported Guides.

Int J Oral Maxillofac Implants 2022 May-Jun;37(3):479-484

Purpose: The increasing popularity of desktop 3D printers makes guided surgery more accessible. The aim of this in vitro study was to evaluate the accuracy of single-tooth guided implant surgery by means of a 3D-printed tooth-supported guide.

Materials And Methods: Fifteen implants were virtually planned to replace a missing first mandibular molar, using planning software for guided implant surgery (Exoplan, Exocad). Read More

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Corrective osteotomy for complex tibial deformity in a patient with hereditary vitamin D-resistant hypophosphatemic rickets (HVDRR) using CT-based navigation system and 3D printed osteotomy model.

Comput Assist Surg (Abingdon) 2022 Dec;27(1):84-90

Department of Orthopedic Surgery, Yokohama City University, Yokohama, Japan.

Planning a three-dimensional (3D) osteotomy using computed tomography (CT) data is useful especially in cases with complex deformities. Furthermore, CT-based navigation system allows the preoperative virtual planning to be replicated in actual surgery. However, one disadvantage when using navigation systems is that when osteotomies are performed on tracker-attached bone, the bone fragments on the side that were cut away cannot be tracked. Read More

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December 2022

Simultaneous Anterior and Posterior Approach for Anterior-to-Psoas Lateral Lumbar Interbody Fusion With Robotically Assisted Posterior Instrumentation: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e67-e68. Epub 2022 Apr 20.

Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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Subtemporal Transcollateral Sulcus Approach for Temporal Horn Tumors: 2-Dimensional Operative Video and Description of the Technique.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e10-e15. Epub 2022 Apr 20.

Department of Neurosurgery, The University of Arizona College of Medicine, Phoenix, Arizona, USA.

Introduction: Purely temporal intraventricular tumors are uncommon. Given their deep location, access to these brain tumors can be challenging in terms of preserving brain tissue. The subtemporal approach spares the lateral temporal cortex and is a less traumatic corridor to reach intraventricular temporal tumors. Read More

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Sacroiliac Joint Fusion Using Robotic Navigation: Technical Note and Case Series.

Oper Neurosurg (Hagerstown) 2022 Jul 27;23(1):1-7. Epub 2022 Apr 27.

Department of Neurological Surgery, Division of Spine, Duke University, Durham, North Carolina, USA.

Background: Patients undergoing sacroiliac (SI) fusion can oftentimes experience significant improvements in pain and quality of life.

Objective: To describe a novel application of robotic navigation to assist with minimally invasive SI joint fusion.

Methods: Patients undergoing stand-alone SI joint fusion with ExcelsiusGPS robotic navigation from July 2020 through June 2021 were retrospectively enrolled. Read More

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Feasibility of accelerated image-guided high-dose-rate interstitial brachytherapy with inverse planning simulated annealing (IPSA-HDRBT) for post-operative treatment of pathologically node-negative squamous cell carcinomas of the oral tongue.

Brachytherapy 2022 Jun 14. Epub 2022 Jun 14.

Department of Radiation Oncology, Helen Diller Comprehensive Cancer Care Center, University of California, San Francisco, CA. Electronic address:

Purpose: Inverse planning simulated annealing (IPSA) produces highly conformal dose distributions and quick optimizations for high-dose-rate interstitial brachytherapy (HDRBT). We report our dosimetry and overall outcomes using this approach for the accelerated post-operative treatment of pathologically node-negative squamous cell carcinomas of the oral tongue (OTSCC) with high risk of local recurrence.

Methods: Patients with newly diagnosed pN0 OTSCC treated with partial glossectomy, neck dissection, and post-operative HDRBT alone from 2007 to 2021 were retrospectively reviewed. Read More

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Diagnostic advantage of thin slice 2D MRI and multiplanar reconstruction of the knee joint using deep learning based denoising approach.

Sci Rep 2022 Jun 20;12(1):10362. Epub 2022 Jun 20.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

The purpose of this study is to evaluate whether thin-slice high-resolution 2D fat-suppressed proton density-weighted image of the knee joint using denoising approach with deep learning-based reconstruction (dDLR) with MPR is more useful than 3D FS-PD multi planar voxel image. Twelve patients who underwent MRI of the knee at 3T and 13 knees were enrolled. Denoising effect was quantitatively evaluated by comparing the coefficient of variation (CV) before and after dDLR. Read More

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Computer-assisted intraoral approach in the management of infected comminuted mandibular fractures: Technical notes.

J Stomatol Oral Maxillofac Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Stomatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan China. Electronic address:

In the extraoral approach for mandibular fractures, facial scars and facial nerve injury are common complications. Herein, we introduce an improved surgical technique to reduce fragments of infected comminuted mandibular fractures with the assistance of computer software. Firstly, the model was reset by 3-dimensional (3D) printing, and then the titanium plate was reconstructed on the model. Read More

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Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment.

J Vis Exp 2022 Jun 3(184). Epub 2022 Jun 3.

Women's Health Integrated Research Center, Gynecologic Cancer Center of Excellence, Department of Obstetrics and Gynecology, Uniformed Services University and Walter Reed National Military Medical Center; The John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University; Women's Health Integrated Research Center, Inova Women's Service Line, Inova Health System;

The tumor microenvironment (TME) represents a complex ecosystem comprised of dozens of distinct cell types, including tumor, stroma, and immune cell populations. To characterize proteome-level variation and tumor heterogeneity at scale, high-throughput methods are needed to selectively isolate discrete cellular populations in solid tumor malignancies. This protocol describes a high-throughput workflow, enabled by artificial intelligence (AI), that segments images of hematoxylin and eosin (H&E)-stained, thin tissue sections into pathology-confirmed regions of interest for selective harvest of histology-resolved cell populations using laser microdissection (LMD). Read More

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