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Clin Toxicol (Phila) 2020 Jul 3:1-2. Epub 2020 Jul 3.

Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium.

Hepatic portal venous gas was found at the abdomen CT of a patient who presented abdomonal pain and ileus in the course of colchine-bortezomib therapy. Drug toxicity was suspected as there was no evidence of intestinal ischemia at laparatomy. Read More

Br J Surg 2020 Jul 3. Epub 2020 Jul 3.

Departments of Surgery, Boston, Massachusetts, USA.

Background: Patients undergoing surgery for soft tissue sarcoma have high morbidity rates, particularly after preoperative radiation therapy (RT). An enhanced recovery after surgery (ERAS) programme may improve perioperative outcomes in abdominal surgery. This study reported outcomes of an ERAS programme tailored to patients with soft tissue sarcoma. Read More

Case Rep Surg 2020 16;2020:4196012. Epub 2020 Jun 16.

Division of Abdominal Transplant, Department of Surgery, Saint Louis University, Saint Louis, MO, USA.

Intestinal malrotation usually presents in the pediatric population with midgut volvulus requiring emergency Ladd's procedure. Rarely, it remains asymptomatic and is discovered incidentally only during adulthood when it seldom causes intestinal complications. The scenario of a cirrhotic adult being diagnosed with asymptomatic intestinal malrotation with subsequent intestinal complications is thus extremely rare and to our knowledge has not been previously reported. Read More

Ned Tijdschr Geneeskd 2020 Jun 19;164. Epub 2020 Jun 19.

Isala, Oncologisch Centrum, Zwolle.

Total parenteral nutrition may be considered for a carefully selected group of palliative patients with ileus. Predictive factors include a strong desire to live, low burden of disease other than the ileus and expected increase in quality of life as a result of starting with total parenteral nutrition. Therapy compliance is required and a strong social network is desirable. Read More

Am J Surg 2020 Jun 14. Epub 2020 Jun 14.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan; Department of Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, 3-4-32 Todaijima, Urayasu-city, Chiba, 2790001, Japan.

Background: Long-term outcomes of self-expandable metal stents (SEMSs) as bridges to surgery versus emergency surgery in the treatment of left-sided obstructing colon cancer remain unclear.

Methods: Using a nationwide inpatient database in Japan, we performed one-to-one propensity score matching to compare overall survival, the stoma requirement, postoperative complications, and the length of stay between the SEMS and emergency surgery groups.

Results: Compared with the emergency surgery group, the SEMS group showed worse survival (hazard ratio, 1. Read More

J Nurs Educ 2020 Jul;59(7):382-387

Background: Despite the increasing prevalence of simulation education, a specific clinical judgment measurement model-based simulation module for ileus has yet to be developed.

Method: Using a mixed-methods research design, quantitative data were collected through a survey, and qualitative data were collected through reflective journals. Collected data were used to develop a simulation module, which subsequently was implemented with 88 nursing students from Korea. Read More

ANZ J Surg 2020 Jun 28. Epub 2020 Jun 28.

Colorectal Unit, Department of General Surgery, St John of God Subiaco Hospital, Perth, Western Australia, Australia.

Background: Recent evidence supports the safety of early reversal of a temporary stoma, within 14 days of construction. The aim of this systematic review and meta-analysis was to evaluate the post-operative morbidity and overall feasibility of early stoma reversal.

Methods: Medline and Cochrane databases were searched for studies up to June 2019 that investigated the outcomes of early stoma reversal (EC, defined as closure ≤14 days from the index operation) versus late stoma reversal (LC, ≥8 weeks from the index operation). Read More

Surg Today 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka, 543-0035, Japan.

Purpose: To investigate the efficacy and safety of Daikenchuto (DKT) for colorectal cancer patients undergoing surgery with the potential risk of postoperative ileus (POI).

Methods: Colorectal cancer patients with abdominal pain and distention, scheduled for surgery, were randomly assigned to a DKT group or a control group. Patients assigned to the DKT group were given 15 g of DKT per day during the perioperative period. Read More

Korean J Gastroenterol 2020 Jun;75(6):351-355

Departments of Radiology, Kosin University College of Medicine, Busan, Korea.

Transarterial chemoembolization (TACE) is a common treatment for unresectable hepatocellular carcinoma (HCC). The most common complications after TACE are non-specific symptoms called post-embolization syndrome, such as abdominal pain or fever. Rare complications, such as liver failure, liver abscess, sepsis, pulmonary embolism, cholecystitis, can also occur. Read More

Minerva Anestesiol 2020 Jun 23. Epub 2020 Jun 23.

Department of Anesthesia and Surgical Intensive Care, Brest Teaching Hospital, Brest, France -

Bowel dysfunction, especially ileus, has been increasingly recognized in critically ill patients. Ileus is commonly associated to constipation, however abnormal motility can also concern the upper digestive tract, therefore impaired gastrointestinal transit (IGT) seems to be a more appropriate term. IGT, especially constipation, is common among patients under mechanical ventilation, occurring in up to 80 % of the patients during the first week, and has been associated with worse outcome in intensive care unit (ICU). Read More

Int J Colorectal Dis 2020 Jun 22. Epub 2020 Jun 22.

Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: Enhanced recovery after surgery (ERAS) improves outcomes after elective colorectal operations. Whether it is beneficial for emergency colorectal surgery is unclear. This study aimed to systematically review and summarize evidence from all studies comparing ERAS versus conventional care in patients having emergency colectomy and/or proctectomy for obstructive colorectal cancer. Read More

Pediatr Surg Int 2020 Jun 23. Epub 2020 Jun 23.

Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 3401 Civic Center Blvd, 3NW13, Philadelphia, PA, 19104, USA.

Purpose: We aim to evaluate the diagnostic performance and relationship between clinical characteristics, imaging findings, and final diagnosis for the neonatal contrast enema (CE).

Methods: Retrospective 10-year review of all neonatal CEs including imaging findings, clinical information, indication, and final diagnosis from discharge summaries, surgical reports, and pathology (reference standard). Two blinded pediatric radiologists reinterpreted 366 CEs for obstruction, microcolon, rectosigmoid index (RSI), serrations, meconium, ileal cut-off, transition zone, diagnosis, and level of confidence. Read More

J Surg Res 2020 Jun 18;255:195-204. Epub 2020 Jun 18.

Department of Orthopedics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background: Most surgeons now accept lymphadenectomy as an essential feature of the operative treatment of esophageal squamous cell carcinoma. Three-field and two-field lymphadenectomy are two of the most popular excision scopes among surgeons. Over recent years, researchers have performed a range of comparative studies regarding these techniques, although the conclusions remain inconsistent. Read More

Vet Immunol Immunopathol 2020 May 27;226:110073. Epub 2020 May 27.

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.

Intestinal macrophages are the largest group of mononuclear phagocytes in the body and play a role in intestinal innate immunity, neuroimmune interactions and maintaining intestinal homeostasis. Conversely, they also are implicated in numerous pathologies of the gastrointestinal tract, such as postoperative ileus and inflammatory bowel disease. As a result, macrophages could be potential therapeutic targets. Read More

Intern Emerg Med 2020 Jun 17. Epub 2020 Jun 17.

Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, 67100, L'Aquila, Italy.

Int J Colorectal Dis 2020 Jun 19. Epub 2020 Jun 19.

Department of Colorectal Surgery, Ealing Hospital, North West London Hospitals NHS Trust, London, UK.

Background: We aimed to evaluate comparative outcomes of robotic and laparoscopic total mesorectal excision (TME) in patients with rectal cancer.

Methods: We systematically searched electronic data sources with application of combination of free text and controlled vocabulary search adapted to thesaurus headings, search operators, and limits. Perioperative clinical and short-term oncological outcomes were evaluated. Read More

J Cardiothorac Surg 2020 Jun 17;15(1):142. Epub 2020 Jun 17.

Department of Thoracic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, Anhui, China.

Background: Although jejunostomy is widely used in complete thoracoscopic and laparoscopic minimally invasive Ivor-Lewis esophagectomy, its clinical effectiveness remains undefined. This study aimed to assess the therapeutic and side effects of jejunostomy in patients undergoing Ivor-Lewis esophagectomy for thoracic segment esophageal carcinoma.

Methods: A total of 1400 patients with esophageal carcinoma who underwent minimally invasive esophagectomy in the Thoracic Surgery of our hospital from 2015 to 2018 were retrospectively evaluated. Read More

ACG Case Rep J 2020 Apr 7;7(4):e00363. Epub 2020 Apr 7.

Department of Surgery, Hospital Alemán of Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina.

Gallstone ileus is a rare entity, and an obstructing gallstone in the left colon is even less frequent. A 78-year-old man was evaluated for abdominal distension and pain, associated with a lack of bowel movements in the past 5 days. An abdominal computed tomography showed a cholecystocolonic fistula associated with a gallstone in the descending colon. Read More

Cir Cir 2020 ;88(3):292-296

Departamento de Cirugía General, Centro Médico Instituto de Seguridad Social del Estado de México (ISSEMyM), Ecatepec, Estado de México, México.

Introduction: Gallstone ileus is a rare cause of mechanical bowel obstruction, generally found in elderly patients who often have other significant medical conditions.

Objective: The objective of the study was to determine the prevalence of gallstone ileus and the number of postsurgical complications and outcomes depending on what type of surgical management is performed.

Method: Cohort, retrospective, observational, and comparative study was conducted, which included 31 patients undergoing surgery for gallstone ileus. Read More

Ann R Coll Surg Engl 2020 Jun 15:e1-e4. Epub 2020 Jun 15.

Military Medical Academy, Sofia, Bulgaria.

The reported incidence of intestinal endometriosis varies between 22% and 37%, with bowel obstruction in only 2.3% of cases, but few series report acute obstruction. We report a rare case of acute bowel obstruction due to multiple bilateral deep intestinal endometriosis lesions localised in the ileum, ileocaecal valve and upper rectum, requiring synchronous resection in an emergency setting. Read More

Br J Pain 2020 May 29;14(2):98-103. Epub 2019 Aug 29.

Department of Anaesthesia, Raigmore Hospital, Inverness, UK.

Introduction: Intravenous (IV) lidocaine infusions are increasingly used in the management of acute pain. They are particularly used in patients undergoing colorectal surgery, where they are also found to decrease rates of postoperative ileus. IV lidocaine has significant toxicity in overdose. Read More

J Equine Vet Sci 2020 Jul 30;90:102994. Epub 2020 Mar 30.

Clinical Unit of Anaesthesiology and Perioperative Intensive-Care Medicine, Vetmeduni Vienna, Vienna, Austria.

Colic surgery is one of the most painful procedures carried out in horses. Common strategies to alleviate immediate postsurgical abdominal pain include the administration of potent systemic analgesics; however, these may cause unwanted adverse effects such as cardiovascular depression, ileus, and ataxia. The administration of local anesthetics at the incision site in form of an ultrasound-guided subcostal transversus abdominis plane (TAP) block may therefore be preferred to provide adequate analgesia without significant side effects. Read More

J Neurosurg Spine 2020 Jun 12:1-10. Epub 2020 Jun 12.

3Department of Orthopedic Surgery, University of California, San Francisco, California; and.

Objective: In adult spinal deformity and degenerative conditions of the spine, interbody fusion to the sacrum often is performed to enhance arthrodesis, induce lordosis, and alleviate stenosis. Anterior lumbar interbody fusion (ALIF) has traditionally been performed, but minimally invasive oblique lumbar interbody fusion (OLIF) may or may not cause less morbidity because less retraction of the abdominal viscera is required. The authors evaluated whether there was a difference between the results of ALIF and OLIF in multilevel anterior or lateral interbody fusion to the sacrum. Read More

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S87-S91

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung City, Taiwan.

Background: Vascularized gastroepiploic lymph node flaps have become a popular option to treat patients with extremity lymphedema. Overall, 2 surgical approaches to harvest this flap have been described: laparoscopic and open. In this study, we analyzed complications, harvesting time, and patient satisfaction scores, comparing these 2 techniques. Read More

Orthop Surg 2020 Jun 10. Epub 2020 Jun 10.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To evaluate the efficacy and feasibility of minimally invasive oblique lumbar interbody debridement and fusion for the treatment of conservatively ineffective lumbar spondylodiscitis.

Methods: This is a retrospective study. Between December 2016 and November 2017, a total of 14 consecutive patients (eight males and six females, with an average age of 49. Read More

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wrocław, Poland.

The L-Arginine/NO pathway is involved in carcinogenesis and immunity. Its diagnostic and prognostic value in colorectal cancer (CRC) was determined using tandem mass spectrometry in 199 individuals (137 with CRC) and, during a three-day follow up, in 60 patients undergoing colorectal surgery. Citrulline was decreased and asymmetric (ADMA) and symmetric (SDMA) dimethylarginines and dimethylamine (DMA) were increased in CRC. Read More

World J Clin Cases 2020 May;8(10):2023-2027

Department of General Surgery, Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, Zhejiang Province, China.

Background: The management of recurrent gallstone ileus (GSI) is unsatisfactory, and there is no consensus on how to reduce the incidence of recurrent GSI.

Case Summary: A 79-year-old man presented to the Emergency Department of our hospital complaining of abdominal pain. An abdominal computed tomography (CT) scan revealed cholecystolithiasis, intrahepatic bile duct dilatation, gas accumulation, small intestinal obstruction, and circular high-density shadow in the intestinal cavity. Read More

BMC Cancer 2020 Jun 9;20(1):540. Epub 2020 Jun 9.

Department of Radiology, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Background: Abdominal/pelvic lymph node (LN) oligometastasis, a pattern of treatment failure, is observed occasionally, and radiotherapy may work as salvage therapy. The optimal prescription dose, however, is yet to be determined. This study assessed the efficacy of high-dose radiotherapy. Read More

Gynecol Oncol 2020 Jun 5. Epub 2020 Jun 5.

Oklahoma Cancer Center/Sarah Cannon Research Institute, University of Oklahoma, Oklahoma City, OK, USA. Electronic address:

Objective: Epithelial ovarian carcinoma (EOC) is diagnosed at advanced stage in the majority of women and, despite being initially chemosensitive, eventually recurs and develops resistance to known therapies. SC-003 is a pyrrolobenzodiazepine-based antibody-drug conjugate targeting dipeptidase 3 (DPEP3), a membrane-bound dipeptidase associated with tumor-initiating cells in patient-derived EOC xenograft models. This first-in-human phase 1a/1b study evaluated the safety/tolerability, pharmacokinetics, and preliminary antitumor activity of SC-003 alone or in combination with budigalimab (formerly ABBV-181), an antibody targeting PD-1, in patients with platinum-resistant/refractory EOC (NCT02539719). Read More

Acta Paediatr 2020 Jun 8. Epub 2020 Jun 8.

Pediatric Allergy and Respiratory Unit, 3rd Department of Pediatrics, Attikon" University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Meconium ileus (MI) roughly affects 15% of cystic fibrosis (CF) patients. Although the mortality from MI has been eliminated there remain questions regarding its consequences in the prognosis of CF. Τhe aim of this study was to investigate whether CF patients presenting with MI at birth differ in respiratory function and z-score of body mass index (z-BMI), from CF patients diagnosed by other clinical symptoms. Read More

Gastroenterol Res Pract 2020 15;2020:1625154. Epub 2020 May 15.

Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Background: The ileus tube has been widely used for the treatment of acute small bowel obstruction. However, it is difficult to get the tube sufficiently adjacent to the obstruction site due to various reasons.

Methods: We developed a novel intubation technique, named Deeper Intubation Technique (DIT), by using the Zebra Urological Guidewire and digital gastrointestinal fluoroscopy, where we deepened the catheter intubation, and further compared the effects of DIT with the Traditional Intubation Technique (TIT) on the short-term clinical outcomes of 183 patients. Read More

Inflamm Bowel Dis 2020 Jun 8. Epub 2020 Jun 8.

Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Tongji University, Shanghai, China.

Background: Intestinal fibrosis is the final pathological outcome of chronic intestinal inflammation without specific therapeutic drugs, which leads to ileus and surgical intervention. Intestinal fibrosis is characterized by excessive deposition of extracellular matrix (ECM). The role of mast cells (MCs), which are members of the sentinel immune cell population, is unknown in intestinal fibrosis. Read More

J Surg Res 2020 Jun 4;254:314-317. Epub 2020 Jun 4.

Division of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Background: Postoperative small bowel obstruction (SBO) is an important complication of laparoscopic appendectomy in children, resulting in readmission and potential for intestinal loss. We reviewed our experience with early postoperative SBO.

Methods: A retrospective review was performed of patients undergoing an appendectomy with subsequent SBO from 2014 to 2018. Read More

J Surg Res 2020 Jun 3;254:306-313. Epub 2020 Jun 3.

Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia. Electronic address:

Background: Gastrointestinal complications after cardiac surgery are associated with high morbidity and mortality. We sought to determine the granular impact of individual gastrointestinal complications after cardiac surgery and assess contemporary outcomes.

Materials And Methods: Patients undergoing cardiac surgery from 2010 to 2017 (6070 patients) were identified from an institutional Society of Thoracic Surgeons database. Read More

Langenbecks Arch Surg 2020 May 31. Epub 2020 May 31.

Department of General Surgery, Heilig-Hart Hospital, Mechelsestraat 24, Lier, Belgium.

Purpose: Laparoscopic primary or incisional abdominal hernia repair with intraperitoneal mesh placement is a well-accepted and safe technique. Evidence for complications however remains inconclusive, and little is known about the occurrence of postoperative ileus secondary to postoperative intra-abdominal adhesions with different types of IPOM meshes used. Therefore, we retrospectively compared the occurrence of postoperative ileus between two of the different meshes used in our center. Read More

BMC Ophthalmol 2020 Jun 5;20(1):217. Epub 2020 Jun 5.

Edogawa Hospital, Tokyo, Japan.

Background: The usefulness of povidone-iodine as an alternative to antimicrobial agents, for endophthalmitis, has recently been documented. We report a case of endogenous endophthalmitis successfully treated with intravitreal injection of povidone-iodine.

Case Presentation: An 88-year-old woman underwent small bowel bypass surgery for postoperative ileus following rectal cancer resection. Read More

Ann Plast Surg 2020 Jun 2. Epub 2020 Jun 2.

From the Department of Plastic and Reconstructive Surgery, The University of Tokyo, Bunkyo-ku.

Background: Reconstruction after esophagectomy is conventionally performed with a gastric conduit. However, in cases where a gastric conduit is unavailable, reconstructive procedures vary in terms of flap type, operative timing, and conduit route. Single-stage surgery is associated with a long operation time and high surgical stress, resulting in perioperative mortality. Read More

J Gastrointest Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Radiologe 2020 Jun 3. Epub 2020 Jun 3.

Arbeitsbereich Kinderradiologie, Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Clinical Issue: Abdominal complications are often the first indications for cystic fibrosis (CF), a multiorgan disease. A broad range of abdominal manifestations are associated with the disease, including gastrointestinal abnormalities (such as meconium ileus in newborns and distal intestinal obstruction syndrome in older children) and hepatobiliary alterations (e.g. Read More

Int J Surg Case Rep 2020 29;71:331-334. Epub 2020 May 29.

Department of Surgery, Upper Gastrointestinal Division, Hyogo College of Medicine, Japan.

Introduction: Lumbar hernia is a rare hernia in the posterolateral abdominal wall and only about 310 cases are known to have been reported to date. Laparoscopic hernioplasty is a common surgical approach but is unsuitable for patients who have previously undergone laparotomy and are expected to have extensive visceral adhesions.

Presentation Of Case: An 84-year-old woman who had undergone an open distal gastrectomy was referred to our hospital with an enlarging but easily reducible bulge in the right upper back. Read More

Int J Surg Case Rep 2020 25;71:315-318. Epub 2020 May 25.

General Surgery Department, San Salvatore Hospital, Paternò, Catania, Italy.

Introduction: Bouveret's syndrome is a rare complication of cholelithiasis that determines an unusual type of gallstone ileus, secondary to an acquired fistula between the gallbladder and either the duodenum or stomach with impaction of a large gallbladder stone. Preoperative diagnosis is difficult because of its rarity and the absence of typical symptoms. Adequate treatment consists of endoscopic or surgical removal of obstructive stone. Read More

Wideochir Inne Tech Maloinwazyjne 2020 Jun 24;15(2):268-275. Epub 2020 Feb 24.

Department of General and Gastroenterological Surgery, Tokai University Hachioji Hospital, Tokyo, Japan.

Introduction: In recent years, laparoscopic surgery (LS) has been performed for small bowel obstruction (SBO). However, the indications and short-term and long-term outcomes of LS for SBO have not yet been established.

Aim: To evaluate the usefulness of LS for SBO compared to open surgery (OS), as well as to identify risk factors for poor outcomes after LS. Read More

J Gastroenterol Hepatol 2020 Jun 1. Epub 2020 Jun 1.

Diagnostic Radiology Unit, Division of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background And Aim: Paralytic ileus is a common intestinal dysfunction in critically ill patients, which results in complications and poor hospital outcomes. There are still no established effective medications, except correcting the primary causes and prokinetics trial, which have limited efficacy and potential adverse events. This study aims to evaluate the efficacy of prucalopride on paralytic ileus in critically ill patients. Read More

Cureus 2020 Apr 27;12(4):e7859. Epub 2020 Apr 27.

General Surgery, Hospital do Litoral Alentejano, Santiago do Cacém, PRT.

Cholecystocolic fistulas are uncommon, with rare cases of colonic obstruction described in the literature and even rarer cases of intestinal perforation due to gallstones. We describe a case of a 73-year-old man who presented to our ED with complaints of diffuse abdominal pain, vomiting, constipation, and fever for the past week. Abdomen CT showed signs of acute perforated appendicitis. Read More

Medicine (Baltimore) 2020 May;99(21):e20228

Department of Internal Medicine, Hansung Union Internal Medicine Clinic and Dialysis Center, Daegu, Republic of Korea.

Rationale: Rare cases of euglycemic diabetic ketoacidosis (eu-DKA) have been reported after the administration of sodium-glucose cotransporter-2 (SGLT-2) inhibitors. No reports have described eu-DKA complicated by hypernatremia due to SGLT-2 inhibitors.

Patient Concerns: A 76-year-old woman with a 40-year history of type 2 diabetes mellitus (DM), for which metformin (1000 mg/day) and dapagliflozin (10 mg/day) were prescribed, presented with malaise, fever, and oliguria. Read More

Anesthesiology 2020 May 26. Epub 2020 May 26.

From the Department of Anesthesiology and Critical Care Medicine, Anesthesiology Service, Memorial Sloan Kettering Cancer Center, New York, New York (V.A.-C., A.C.P., M.F.) the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York (K.S.T.) the Department of Surgery, Urology Service, Weill Cornell Medical College, New York, New York. (G.D., H.W.H., B.H.B., E.K.C., T.F.D., S.M.D.) the Department of Urology, Weill Cornell Medical College, New York, New York. (G.D., H.W.H., B.H.B., E.K.C., S.M.D.) Departments of Anesthesiology, Weill Cornell Medical College, New York, New York. (A.C.P., M.F.).

Background: Postoperative ileus is a common complication of intraabdominal surgeries, including radical cystectomy with reported rates as high as 32%. Perioperative fluid administration has been associated with improvement in postoperative ileus rates, but it is difficult to generalize because earlier studies lacked standardized definitions of postoperative ileus and other relevant outcomes. The hypothesis was that targeted individualized perioperative fluid management would improve postoperative ileus in patients receiving radical cystectomy. Read More

Pediatr Pulmonol 2020 May 29. Epub 2020 May 29.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

The introduction of NBS in Ireland in July 2011, provided a unique opportunity to investigate clinical outcomes using a comparative historical cohort study. Clinical cohort: children clinically diagnosed with CF born 1 July 2008 to 30 June 2011, and NBS cohort: children diagnosed with CF through NBS born 1 July 2011 to 30 June 2016. Clinical data were collected from the CF Registry of Ireland, medical charts, and data on weight/height before diagnosis from public health nurses and family doctors. Read More

Ann Pharmacother 2020 May 29:1060028020929061. Epub 2020 May 29.

The University of Tennessee Medical Center, Knoxville, TN, USA.

Neuromuscular blockers (NMBs) used during surgery have historically been reversed with acetylcholinesterase inhibitors and anticholinergic agents, which can slow gastrointestinal motility. Sugammadex (SUG) provides NMB reversal with minimal effects on gastrointestinal motility. The purpose of this study was to determine if SUG for reversal of NMB is associated with decreased time to first bowel movement (BM) following laparoscopic colorectal surgery. Read More

Surg Endosc 2020 May 28. Epub 2020 May 28.

Division of Colorectal Surgery, University Surgical Cluster, National University Hospital, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Introduction: Enhanced recovery after surgery (ERAS) programs for patients undergoing colorectal surgery has yielded promising results. However, there remains controversy regarding the application of ERAS protocols in an elderly population. The aim of this review is to compare the clinical outcomes between ERAS versus conventional peri-operative care (Non-ERAS) for colorectal surgery in patients aged ≥ 65 years old. Read More

Future Oncol 2020 May 29. Epub 2020 May 29.

Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Gastric cancer patients with severe peritoneal metastases, defined as massive ascites and/or inadequate oral intake, have been excluded from clinical trials of new treatments due to poor prognosis and tumor-related complications, such as ileus. Based on the results of the JCOG1108/WJOG7312G study, their prognosis when treated with 5-fluorouracil/-leucovorin or 5-fluorouracil/-leucovorin plus paclitaxel remained extremely poor in this setting. Retrospective studies have shown the promising efficacy of the modified FOLFOX6 (mFOLFOX6) regimen, with improved ascites and oral intake. Read More