9,607 results match your criteria IgA Nephropathy


Endothelin receptor antagonists for the treatment of diabetic and nondiabetic chronic kidney disease.

Curr Opin Nephrol Hypertens 2021 May 10. Epub 2021 May 10.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Division of Nephrology, University of Utah Health, Salt Lake City, Utah, USA University of Edinburgh/British Heart Foundation Centre of Research Excellence, Centre for Cardiovascular Science, Queen's Medical Research Institute Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.

Purpose Of Review: To summarize new clinical findings of endothelin receptor antagonists (ERA) in various etiologies of kidney disease targeted in clinical trials.

Recent Findings: Endothelin-1 is a multifunctional peptide with potential relevance to glomerular and tubulointerstitial kidney diseases. The phase 3 SONAR trial demonstrated a significant reduction in clinically relevant kidney outcomes for patients with diabetic kidney disease (DKD) after long-term treatment with the ERA, atrasentan, in addition to blockade of the renin-angiotensin-aldosterone system. Read More

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Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases.

Turk J Med Sci 2021 May 14. Epub 2021 May 14.

Background And Aim: Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in AA amyloidosis patients. The reason for the difference in MPV levels in FMF patients with and without AA amyloidosis is unclear. The aim of the study was to determine whether low MPV is unique to AA amyloidosis or MPV is similarly low in all glomerular diseases as a result of proteinuria and/or renal dysfunction. Read More

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An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy.

Authors:
Ron Hogg

Pediatr Nephrol 2021 May 13. Epub 2021 May 13.

, Kailua Kona, HI, USA.

In recent years, many significant advances have been made in determining which clinical manifestations and pathologic lesions can provide prognostic information for patients with IgA nephropathy (IgAN). However, some important questions remain, including the long-term consequences of hematuria, both macroscopic (MH) and microscopic (mH), in patients with IgAN. The importance of distinguishing patients who have a single episode of MH of long duration from those with recurrent episodes of short duration and the prognostic importance of the episodes of acute kidney injury (AKI) that sometimes accompany episodic MH will be discussed. Read More

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Utility of remission criteria for the renal prognosis of IgA nephropathy.

Clin Exp Nephrol 2021 May 11. Epub 2021 May 11.

Department of Nephrology, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-Ku, Tokyo, 113-8421, Japan.

Background: Novel criteria for the remission of Immunoglobulin A nephropathy (IgAN) based on an opinion survey of Japanese nephrologists and literature review were proposed in 2013. This single-center, longitudinal retrospective cohort study was conducted to validate this criteria.

Methods: Present study included the IgAN patients diagnosed between 2001 and 2005 in the Juntendo University Hospital. Read More

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Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study.

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

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December 2021

Multimodal imaging of bilateral ischemic retinal vasculopathy associated with Berger's IgA nephropathy: case report.

BMC Ophthalmol 2021 May 8;21(1):204. Epub 2021 May 8.

Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, University Paris Est Créteil, 40 Avenue de Verdun, 94000, Créteil, France.

Background: Berger's IgA nephropathy (IgAN) is the most common primary glomerulonephritis. However, some rare cases of retinal manifestations have been described, with only two cases of retinal vasculopathy reported in the literature. Here we report an uncommon case of bilateral ischemic retinal vasculopathy associated with Berger IgAN, evaluated with complete multimodal imaging including ultra-wide field (UWF) imaging and swept source optical coherence tomography angiography (SS-OCTA). Read More

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Nasal-associated lymphoid tissue is the major induction site for nephritogenic IgA in murine IgA nephropathy.

Kidney Int 2021 May 4. Epub 2021 May 4.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan. Electronic address:

Dysregulation of mucosal immunity may play a role in the pathogenesis of IgA nephropathy (IgAN). However, it is unclear whether the nasal-associated lymphoid tissue (NALT) or gut-associated lymphatic tissue is the major induction site of nephritogenic IgA synthesis. To examine whether exogenous mucosal antigens exacerbate the pathogenesis of IgAN, we assessed the disease phenotypes of IgAN-onset ddY mice housed germ-free. Read More

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Tubular decoy receptor 2 as a predictor of prognosis in patients with immunoglobulin A nephropathy.

Clin Kidney J 2021 May 27;14(5):1458-1468. Epub 2021 Jan 27.

Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.

Background: Accelerated senescence of renal tubular epithelial cells (RTECs) might contribute to immunoglobulin A nephropathy (IgAN) progression. This study aimed to determine whether the RTEC senescence marker, decoy receptor 2 (DcR2), could predict prognosis in IgAN.

Methods: We included a retrospective cohort of 105 patients with biopsy-proven IgAN. Read More

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Relationship between blood neutrophil-lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients.

J Clin Lab Anal 2021 May 5:e23774. Epub 2021 May 5.

Department of Nephrology, Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

Background: The study aimed to explore the relationship between neutrophil-lymphocyte ratio(NLR) in peripheral blood and renal tubular atrophy/interstitial fibrosis and to evaluate the clinical significance of NLR in IgA nephropathy (IgAN) patients.

Methods: A Total of 263 IgAN patients were included. The participants were categorized into four groups based on quartile of NLR. Read More

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Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Kidney Research Institute, Seoul National University, Seoul, Korea.

Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous nephropathy, patients with minimal change disease, patients with lupus nephritis and healthy controls, respectively. Read More

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Using MEST-C Scores and the International Study of Kidney Disease in Children Classification to Predict Outcomes of Henoch-Schönlein Purpura Nephritis in Children.

Front Pediatr 2021 14;9:658845. Epub 2021 Apr 14.

Department of Pediatrics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) bear similarities in some aspects. The histological classification of HSPN was built on the International Study of Kidney Disease in Children (ISKDC) criteria, while IgAN was established on the 2016 Oxford classification (MEST-C scores). The purpose of this paper was to discuss the predictive value of the ISKDC classification and MEST-C scores in children with HSPN. Read More

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A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy.

Cureus 2021 Mar 29;13(3):e14165. Epub 2021 Mar 29.

Internal Medicine, Henry Ford Health System, Detroit, USA.

Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. Read More

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An Interpretable Machine Learning Survival Model for Predicting Long-term Kidney Outcomes in IgA Nephropathy.

AMIA Annu Symp Proc 2020 25;2020:737-746. Epub 2021 Jan 25.

Ping An Healthcare Technology, Beijing.

IgA nephropathy (IgAN) is common worldwide and has heterogeneous phenotypes. Predicting long-term outcomes is important for clinical decision-making. As right-censored patients become common during the long-term follow-up, either excluding these patients from the cohort or labeling them as control will bias the risk estimation. Read More

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January 2021

A Partial Picture of the Single-Cell Transcriptomics of Human IgA Nephropathy.

Front Immunol 2021 16;12:645988. Epub 2021 Apr 16.

Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China.

The molecular mechanisms underlying renal damage of IgA nephropathy (IgAN) remain incompletely defined. Here, single-cell RNA sequencing (scRNA-seq) was applied to kidney biopsies from IgAN and control subjects to define the transcriptomic landscape at single-cell resolution. We presented a comprehensive scRNA-seq analysis of human renal biopsies from IgAN. Read More

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Astragaloside IV Inhibits Galactose-Deficient IgA1 Secretion miR-98-5p in Pediatric IgA Nephropathy.

Front Pharmacol 2021 16;12:658236. Epub 2021 Apr 16.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.

The factor associated with IgA nephropathy (IgAN) is an abnormality of IgA known as galactose-deficient IgA1 (Gd-IgA1). The purpose of this study was to determine the molecular role played by miRNAs in the formation of Gd-IgA1 in IgAN and investigate the regulatory role of Astragaloside IV (AS-IV) in miRNAs. Bioinformatics analysis, along with functional and mechanistic experiments, were used to investigate the relationship and function of miRNA, β-1, 3-galactosyltransferase (C1GALT1), Gd-IgA1, and AS-IV. Read More

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Extracellular vesicles in renal inflammatory and infectious diseases.

Free Radic Biol Med 2021 Apr 29;171:42-54. Epub 2021 Apr 29.

Department of Pediatrics, Clinical Sciences Lund, Lund University, 22185, Lund, Sweden.

Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Read More

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A case of gross hematuria and IgA nephropathy flare-up following SARS-CoV-2 vaccination.

Kidney Int 2021 Apr 28. Epub 2021 Apr 28.

Department of Nephrology, Rogosin Institute, New York, New York, USA.

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Paraneoplastic immunoglobulin A nephropathy in a patient with lung adenocarcinoma: A case report and literature review.

J Int Med Res 2021 Apr;49(4):300060521996868

Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Immunoglobulin A nephropathy (lgAN) is a common primary glomerulonephritis, but paraneoplastic IgAN has been rarely reported. This current case report describes a 49-year-old male patient that was referred with proteinuria, oedema and hypoproteinaemia after lung cancer surgery and before the first cycle of chemotherapy. Renal biopsy confirmed lgAN. Read More

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The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients.

J Clin Med 2021 Apr 27;10(9). Epub 2021 Apr 27.

Department of Internal Medicine, Daejeon St. Mary's Hospital, Catholic University of Korea, Daejeon 34943, Korea.

Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) is a well-known primary glomerular nephropathy. Hyperuricemia is associated with a poor prognosis in IgAN patients. Read More

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Rifaximin as a Potential Treatment for IgA Nephropathy in a Humanized Mice Model.

J Pers Med 2021 Apr 16;11(4). Epub 2021 Apr 16.

INSERM U1149, Centre de Recherche sur l'Inflammation, 75018 Paris, France.

IgA Nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by the mesangial deposition of abnormally glycosylated IgA1 (Gd-IgA). The production of Gd-IgA occurs in mucose-associated lymphoid tissue (MALT). The microbiota plays a role in MALT modulation. Read More

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Glomerular Diseases in Diabetic Patients: Implications for Diagnosis and Management.

J Clin Med 2021 Apr 24;10(9). Epub 2021 Apr 24.

Department of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY 10032, USA.

The prevalence of diabetes continues to rise worldwide. In addition to rising rates of diabetic kidney disease, we are also seeing a parallel rise in nondiabetic kidney disease among patients with diabetes. These nondiabetic lesions include focal segmental glomerulosclerosis, IgA nephropathy, membranous nephropathy, and other glomerular diseases. Read More

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Machine Learning in Prediction of IgA Nephropathy Outcome: A Comparative Approach.

J Pers Med 2021 Apr 17;11(4). Epub 2021 Apr 17.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.

We are overwhelmed by a deluge of data and, although its interpretation is challenging, fortunately, information technology comes to the rescue. One of the tools is artificial intelligence, allowing the identification of relationships between variables and their arbitrary classification. We focused on the assessment of both the remission of proteinuria and the deterioration of kidney function in patients with IgA nephropathy, comparing several methods of machine learning. Read More

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Endotrophin, a collagen type VI-derived matrikine, reflects the degree of renal fibrosis in patients with IgA nephropathy and in patients with ANCA-associated vasculitis.

Nephrol Dial Transplant 2021 Apr 29. Epub 2021 Apr 29.

Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.

Background: Renal fibrosis is the hallmark of chronic kidney disease (CKD) and characterized by an imbalanced extracellular matrix remodeling. Endotrophin (ETP) is a signaling molecule released from collagen type VI (COL VI). ETP can be measured by the PRO-C6 assay, which quantifies the levels of COL VI formation. Read More

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Anti-glomerular basement membrane disease mediated by IgG and IgA: a case report.

Ren Fail 2021 Dec;43(1):774-778

Department of Nephrology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Background: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune condition responsible for rapidly progressive glomerulonephritis. This disease is usually mediated by IgG autoantibodies against the noncollagenous domain of the α3(IV) collagen chain. In rare cases, IgA or IgM anti-GBM antibodies are involved. Read More

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December 2021

The Clinical Significance and Potential Role of Cathepsin S in IgA Nephropathy.

Front Pediatr 2021 12;9:631473. Epub 2021 Apr 12.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Cathepsin S (CTSS) is an important lysosomal cysteine protease. This study aimed at investigating the clinical significance of CTSS and underlying mechanism in immunoglobulin A nephropathy (IgAN). This study recruited 25 children with IgAN and age-matched controls and their serum CTSS levels were measured by enzyme-linked immunosorbent assay (ELISA). Read More

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