10,607 results match your criteria IgA Nephropathy


Assessment of renal microcirculation in biopsy-proven tubulointerstitial nephritis in patients with and without glomerular disease: the role of resistive index.

Microvasc Res 2022 May 16;142:104379. Epub 2022 May 16.

Department of Translational and Precision Medicine, "Sapienza", University of Rome, Italy. Electronic address:

Background: Renal resistive index (RRI) measured by Doppler sonography is a marker of microvascular status and it is associated with changes in renal function. Aim of the study was to assess RRI in biopsy-proven tubulointerstitial nephritis (TIN) in patients with and without glomerular disease.

Methods: 132 consecutive patients underwent to native renal biopsy with diagnosis of isolated TIN or in association with glomerulonephritis. Read More

View Article and Full-Text PDF

IgA nephropathy associated with anti-PLA2R antibody positive: a case report.

Int Urol Nephrol 2022 May 19. Epub 2022 May 19.

Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.

View Article and Full-Text PDF

Analysis of Various Types of Glomerulonephritis with Crescents at a Single Center.

Int J Nephrol 2022 9;2022:1749548. Epub 2022 May 9.

Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: The importance of crescent formation in glomerulonephritis has increased. However, detailed analysis of crescentic glomerulonephritis in Asia is scarce. In addition, advances in serological diagnostic techniques (antineutrophil cytoplasmic and antiglomerular basement membrane autoantibodies) and early diagnosis have reduced the number of cases meeting the strict definition of crescentic glomerulonephritis (>50% of glomeruli are crescentic). Read More

View Article and Full-Text PDF

A noninvasive artificial neural network model to predict IgA nephropathy risk in Chinese population.

Sci Rep 2022 May 18;12(1):8296. Epub 2022 May 18.

Department of Nephrology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.

Renal biopsy is the gold standard for Immunoglobulin A nephropathy (IgAN) but poses several problems. Thus, we aimed to establish a noninvasive model for predicting the risk probability of IgAN by analyzing routine and serological parameters. A total of 519 biopsy-diagnosed IgAN and 211 non-IgAN patients were recruited retrospectively. Read More

View Article and Full-Text PDF

[IgA vasculitis - similarities and differences to IgA nephropathy].

Ther Umsch 2022 Jun;79(5):260-268

Klinik Rheumatologie & Schmerzmedizin, Bethesda Spital Basel.

IgA vasculitis - similarities and differences to IgA nephropathy IgA vasculitis (IgAV), formerly called Henoch-Schönlein Purpura (HSP) is an immune complex-mediated vasculitis of small vessels typically affecting the skin, gastrointestinal tract, and the kidneys. Based on distinct histopathological and pathophysiological commonalities of IgAV and IgA nephropathy (IgAN) they are viewed as part of a spectrum of IgA-mediated inflammatory syndromes. While the disease course in children is most often benign, IgAV has a high risk of renal and gastrointestinal complications when first appearing in adulthood. Read More

View Article and Full-Text PDF

Is There a Role for More Intense Immunosuppression in IgA Nephropathy?

Authors:
Abraham W Aron

Kidney360 2022 Mar 4;3(3):410-412. Epub 2022 Feb 4.

Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut.

View Article and Full-Text PDF

Effect of Cyclophosphamide and Glucocorticoid Therapy in IgA Nephropathy: A Single-Center Retrospective Analysis.

Kidney360 2022 Mar 19;3(3):506-515. Epub 2022 Jan 19.

Department of Medicine IV, University Freiburg, Medical Center, Freiburg, Germany.

Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in adults, which causes ESKD in ≤45% of patients in the long term. The optimal therapeutic approach remains undetermined. In this study, we report the results of a single-center retrospective analysis of patients with IgAN. Read More

View Article and Full-Text PDF

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis.

Sci Rep 2022 May 17;12(1):8234. Epub 2022 May 17.

University of Melbourne Department of Medicine (Melbourne Health), Parkville, VIC, 3076, Australia.

Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis. Consecutive individuals with glomerulonephritis attending a general renal or transplant clinic underwent retinal imaging with a non-mydriatic camera. Read More

View Article and Full-Text PDF

Oral Glucocorticoids for IgA Nephropathy.

Authors:
Kirk N Campbell

JAMA 2022 05;327(19):1872-1874

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

View Article and Full-Text PDF

Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial.

JAMA 2022 05;327(19):1888-1898

The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Importance: The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.

Objective: To evaluate the efficacy and adverse effects of methylprednisolone in patients with IgA nephropathy at high risk of kidney function decline.

Design, Setting, And Participants: An international, multicenter, double-blind, randomized clinical trial that enrolled 503 participants with IgA nephropathy, proteinuria greater than or equal to 1 g per day, and estimated glomerular filtration rate (eGFR) of 20 to 120 mL/min/1. Read More

View Article and Full-Text PDF

Kidney Disease in Ankylosing Spondylitis: a case series and review of the literature.

J Bras Nefrol 2022 May 13. Epub 2022 May 13.

Centro Hospitalar de Lisboa Central, Hospital Curry Cabral, Departamento de Nefrologia, Lisboa, Portugal.

Background: Kidney disease is a rare manifestation of ankylosing spondylitis (AS) and its pathological alterations remain poorly described. The aim of this study was to investigate the clinical presentation and pathological alterations on kidney biopsy of AS patients and review and discuss the current literature on the issue.

Methods: We retrospectively studied the clinical presentation and kidney pathological alterations of 15 Caucasian AS patients submitted to kidney biopsy between October 1985 and March 2021. Read More

View Article and Full-Text PDF

Renal Interstitial Inflammation Predicts Nephropathy Progression in IgA Nephropathy: A Two-Center Cohort Study.

Am J Nephrol 2022 May 16:1-15. Epub 2022 May 16.

Department of Nephrology, Hangzhou Hospital of Chinese Medicine (Guangxing Hospital), Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, China.

Introduction: Renal interstitial inflammation often presents in immunoglobulin A nephropathy (IgAN), but its predictive role in kidney disease progression remains controversial.

Methods: This retrospective two-center cohort study included 1,420 adult IgAN patients between January 2003 and May 2018 followed for a median of approximately 7 years at two Chinese hospitals. The predictor was renal interstitial inflammation within the total cortical interstitium (none/mild [0-25%], moderate [26-50%], or severe [>50%]). Read More

View Article and Full-Text PDF

Sofosbuvir and ledipasvir decreased nephrotic syndrome caused by IgA nephropathy with a membranoproliferative pattern of injury in hepatitis C virus-induced cirrhosis: a case report.

Ann Transl Med 2022 Apr;10(8):494

Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Immunoglobulin (Ig) A nephropathy (IgAN) with a membranoproliferative pattern of injury that manifests as nephrotic syndrome (NS) is rarely reported in hepatitis C virus (HCV)-induced cirrhosis. It is not known whether eradication of HCV by direct-acting antiviral (DAA) drugs can lead to remission of proteinuria and improve the long-term prognosis.

Case Description: We report the case of a 52-year-old woman with HCV cirrhosis for 10 years. Read More

View Article and Full-Text PDF

Comparison of Complement Pathway Activation in Autoimmune Glomerulonephritis.

Kidney Int Rep 2022 May 14;7(5):1027-1036. Epub 2022 Feb 14.

Division of Nephrology, Hôpital du Sacré-Coeur de Montréal, Quebec, Canada.

Introduction: Studies on complement activation have implicated a combination of the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP) in triggering the terminal pathway (TP) for each common autoimmune glomerulonephritis (GN). Evaluating different pathways simultaneously may help identify whether one is preferentially activated and, consequently, which is best to target for each disease.

Methods: We followed 112 patients with focal segmental glomerular sclerosis (FSGS), membranous nephropathy (MN), IgA nephropathy (IgAN), lupus nephritis (LN), and antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) for a median duration of 22 (12-52) months. Read More

View Article and Full-Text PDF

Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort.

Kidney Int Rep 2022 May 14;7(5):1004-1015. Epub 2022 Feb 14.

Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.

Introduction: Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology.

Methods: Participants ( = 5095, aged 18-74 years) of the ongoing multicenter German Chronic Kidney Disease (GCKD) cohort, enrolled on the basis of an estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min (stages G3, A1-A3) or overt proteinuria (stages G1-G2, A3), were divided into 3 categories according to their educational attainment and were followed for 6. Read More

View Article and Full-Text PDF

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VIS649 (Sibeprenlimab), an APRIL-Neutralizing IgG Monoclonal Antibody, in Healthy Volunteers.

Kidney Int Rep 2022 May 8;7(5):993-1003. Epub 2022 Feb 8.

Visterra, Inc., Waltham, Massachusetts, USA.

Introduction: VIS649 (sibeprenlimab), a humanized IgG monoclonal antibody that inhibits APRIL, is being developed as a potential treatment for IgA nephropathy (IgAN). This phase 1, first-in-human, randomized, double-blind, single ascending dose study aimed to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of VIS649 in healthy adults.

Methods: Participants were randomized to VIS649 (sequential i. Read More

View Article and Full-Text PDF

Development and Evaluation of a Robust Sandwich Immunoassay System Detecting Serum WFA-Reactive IgA1 for Diagnosis of IgA Nephropathy.

Int J Mol Sci 2022 May 5;23(9). Epub 2022 May 5.

Reagent Engineering, Protein Technology Group, Sysmex Corporation, Kobe 651-2271, Hyogo, Japan.

Aberrant glycosylation of IgA1 is involved in the development of IgA nephropathy (IgAN). There are many reports of IgAN markers focusing on the glycoform of IgA1. None have been clinically applied as a routine test. Read More

View Article and Full-Text PDF

IgA nephropathy with glomerular capillary IgA deposition following SARS-CoV-2 mRNA vaccination: a report of three cases.

CEN Case Rep 2022 May 13. Epub 2022 May 13.

Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

IgA nephropathy (IgAN) cases histopathologically showing glomerular capillary IgA deposition represent a rare subtype of primary IgAN. Patients with IgAN categorized to this subtype often exhibit heavy proteinuria, advanced histological findings, and are resistant to therapies. Here, we report three cases of biopsy-proven IgAN with glomerular capillary IgA deposition who presented acute deterioration of urinalysis findings following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccinations. Read More

View Article and Full-Text PDF

Multi-organ involvement and intratubular calcium phosphate deposition in the kidney biopsy: what should we investigate?

Eat Weight Disord 2022 May 12. Epub 2022 May 12.

Nephrology Department, Hospital Universitari de Girona Doctor Josep Trueta, Avinguda de França S/N, 17007, Girona, Spain.

Background: Anorexia nervosa is frequently associated with alcohol use disorder. Both of them may adversely affect almost every body system, leading to worse clinical outcomes and high mortality risk. Nonetheless, there is little evidence interrelating anorexia nervosa, alcohol use disorder, and kidney failure. Read More

View Article and Full-Text PDF

Urine Screening and 9 Years' Medical Record System Follow-Up Among School Students in Wenzhou, China.

Front Pediatr 2022 25;10:862029. Epub 2022 Apr 25.

Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

School urinary screening programming can be useful for the early detection of renal and urinary disorders. However, urine screening is not included in the school health check-up in our region. Therefore, from February 2012 to March 2021, 12,497 school students were screened for urinalysis, and a long-term follow-up took place an electronic medical record system. Read More

View Article and Full-Text PDF

Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.

J Am Soc Nephrol 2022 May 11. Epub 2022 May 11.

Department of Immunology, Complutense University and Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain

Background: C3 glomerulopathy (C3G) is a heterogeneous group of chronic renal diseases characterized predominantly by glomerular C3 deposition and complement dysregulation. Mutations in factor H-related (FHR) proteins resulting in duplicated dimerization domains are prototypical of C3G, although the underlying pathogenic mechanism is unclear.

Methods: Using and assays, we performed extensive characterization of an FHR-1 mutant with a duplicated dimerization domain. Read More

View Article and Full-Text PDF

A multicenter, randomized, open-label, comparative, phase IV study to evaluate the efficacy and safety of combined treatment with mycophenolate mofetil and corticosteroids in advanced immunoglobulin A nephropathy.

Kidney Res Clin Pract 2022 May 4. Epub 2022 May 4.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: It remains unclear whether immunosuppressive agents are effective in patients with immunoglobulin A nephropathy (IgAN). We investigated the efficacy of a mycophenolate mofetil (MMF) and corticosteroid combination therapy in patients with advanced IgAN.

Methods: We conducted a multicenter, randomized, placebo-controlled, parallel-group study of 48 weeks administration of MMF and corticosteroids in biopsy-proven advanced IgAN patients with estimated glomerular filtration rate (eGFR) of 20-50 mL/min/1. Read More

View Article and Full-Text PDF

External validation of the International Prediction Tool in Korean patients with immunoglobulin A nephropathy.

Kidney Res Clin Pract 2022 May 4. Epub 2022 May 4.

Department of Internal Medicine and Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The International IgA Nephropathy Prediction Tool (IIgAN-PT) has been recently developed to estimate the progression risk of immunoglobulin A nephropathy (IgAN). This study aimed to evaluate the clinical performance of this prediction tool in a large IgAN cohort in Korea.

Methods: The study cohort was comprised of 2,064 patients with biopsy-proven IgAN from four medical centers between March 2012 and September 2021. Read More

View Article and Full-Text PDF

Effectiveness and safety of KunXian capsule for the treatment of IgA nephropathy.

BMC Nephrol 2022 05 10;23(1):179. Epub 2022 May 10.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.

Background: Tripterygium Wilfordii Hook F (TwHF) preparation has been widely used in the treatments of IgA nephropathy (IgAN) in China. However, the effectiveness and safety of the new generation of TwHF preparation, KuxXian capsule, on the treatment of IgAN remains unknown.

Methods: Here, we retrospectively describe our experience treating 55 consecutive IgAN patients with KunXian. Read More

View Article and Full-Text PDF

Recurrence of IgA nephropathy after kidney transplantation: experience from the Swiss transplant cohort study.

BMC Nephrol 2022 05 10;23(1):178. Epub 2022 May 10.

Division of Nephrology, Cantonal Hospital Aarau, Aarau, Switzerland.

Background: Recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in about 30% of patients. The relevance of recurrence for the long-term graft survival is expected to increase, since graft survival continues to improve.

Methods: In a nested study within the Swiss Transplant Cohort Study the incidence of IgAN recurrence, predictive factors, graft function and graft and patient survival were evaluated. Read More

View Article and Full-Text PDF

The Diagnostic and Predictive Significance of Immune-Related Genes and Immune Characteristics in the Occurrence and Progression of IgA Nephropathy.

J Immunol Res 2022 28;2022:9284204. Epub 2022 Apr 28.

Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, Shanxi 030012, China.

Objective: To investigate the potential diagnostic and predictive significance of immune-related genes in IgA nephropathy (IgAN) and discover the abnormal glomerular inflammation in IgAN.

Methods: GSE116626 was used as a training set to identify different immune-related genes (DIRGs) and establish machine learning models for the diagnosis of IgAN; then, a nomogram model was generated based on GSE116626, and GSE115857 was used as a test set to evaluate its clinical value. Short Time-Series Expression Miner (STEM) analysis was also performed to explore the changing trend of DIRGs with the progression of IgAN lesions. Read More

View Article and Full-Text PDF

IL-6 and its role in IgA nephropathy development.

Cytokine Growth Factor Rev 2022 Apr 20. Epub 2022 Apr 20.

Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 779 00, Czech Republic. Electronic address:

IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro- and anti-inflammatory activities, depending on the receptor variant and the induced intracellular cis- or trans-signaling responses. IL-6-activated pathways are involved in the regulation of cell proliferation, survival, differentiation, and cell metabolism changes. Deviations in IL-6 levels or abnormal response to IL-6 signaling are associated with several autoimmune diseases including IgA nephropathy (IgAN), one of most frequent primary glomerulonephritis worldwide. Read More

View Article and Full-Text PDF

A Case of Seronegative Full-house Nephropathy with Crohn's Disease.

Intern Med 2022 May 7. Epub 2022 May 7.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular "full-house" immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a "full-house" immunofluorescence pattern. Read More

View Article and Full-Text PDF

Regional variations in nephrology trainee confidence with clinical skills may relate to the availability of local training opportunities in the UK: results from a national survey.

Clin Exp Nephrol 2022 May 7. Epub 2022 May 7.

Department of Renal Transplantation and Nephrology, University Hospitals of Coventry and Warwickshire, Coventry, UK.

Background: The United Kingdom offers a standardised training program for nephrology fellows. However, local training opportunities vary resulting in mismatches between trainee interests and accessible opportunities. This may impact trainee confidence, satisfaction, and future service provision. Read More

View Article and Full-Text PDF