51,493 results match your criteria IgA Nephropathy


Screening for Q fever. A tertiary care hospital-based experience in central Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1195-1199

Department of Pathology, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the presence of Coxiella burnetii  (C. brunetii) infection among patients presenting with fever of unknown origin (FUO).

Methods: A cross-sectional study of 100 patients (54 men and 46 women; mean age: 34. Read More

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December 2018

High renal DC-SIGN cell density is associated with severe renal lesions and poor prognosis in patients with Immunoglobulin A Nephropathy.

Histopathology 2018 Dec 5. Epub 2018 Dec 5.

Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.

Background And Objectives: In this observational cohort study, we assessed the prognostic value of DC-SIGN cells in pathogenesis and progression of IgA nephropathy (IgAN).

Design, Setting, Participants, & Measurements: A total of 139 adult IgAN patients were enrolled in this study from June 2009 to June 2010. We characterized DC-SIGN cells by immunohistochemistry or immunofluorescence in renal biopsy tissue. Read More

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December 2018

Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway.

Inflammation 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Affiliated Hospital of Southwest Medical University, No. 25, Tai Ping Street, Jiangyang District, 646000, Luzhou, China.

Schisandrin B (SchB) is an active compound extracted from the Chinese herb Schisandra chinensis and shows excellent anti-inflammatory activity. This study was performed to examine the effects of SchB in a rat model of IgA nephropathy (IgAN). IgAN was established in Sprague-Dawley rats by immunization with lipopolysaccharide (LPS), bovine serum albumin, and carbon tetrachloride. Read More

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December 2018

Hypertensive crisis with massive retinal and choroidal infarction: A case update.

Am J Ophthalmol Case Rep 2019 Mar 10;13:22-24. Epub 2018 Nov 10.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We report an update on a recently published case of uncontrolled hypertension secondary to immunoglobulin A (IgA) nephropathy resulting in massive bilateral retinal and choroidal infarction.

Observations: In our previous report, we presented a 30-year old female with end-stage renal disease who complained of painless vision loss after many missed hemodialysis. The patient was found to be in hypertensive crisis resulting in massive retinal and choroidal infarction with severe vision loss in both eyes. Read More

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March 2019
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Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken.

Front Immunol 2018 21;9:2731. Epub 2018 Nov 21.

College of Animal Science and Technology, Northwest A&F University, Xi'an, China.

One hundred and twenty one-day-old breeder cocks, included 15 cages of 8 birds each, were fed to learn the aging's effect on chicken's thymus immunity. At 2 (2-W) and 40 (40-W) weeks of age, one chicken each cage was randomly chosen and slaughtered to get the thymus sample. The results showed that thymus weight and morphology of 40-W group were far different from that of 2-W group, and exhibited a property of degeneration. Read More

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November 2018

Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses.

Front Immunol 2018 21;9:2679. Epub 2018 Nov 21.

Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.

Antibody class switch recombination (CSR) to IgG, IgA, or IgE is a hallmark of adaptive immunity, allowing antibody function diversification beyond IgM. CSR involves a deletion of the IgM/IgD constant region genes placing a new acceptor Constant gene, downstream of the VDJ exon. CSR depends on non-coding (CSRnc) transcription of donor I and acceptor I exons, located 5' upstream of each C coding gene. Read More

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November 2018
1 Read

Childhood IgA Nephropathy Successfully Treated with Targeted-Release Budesonide: A Case Report.

J Paediatr Child Health 2018 Dec;54(12):1403

Department of Nephrology, Perth Children's Hospital, Australia.

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December 2018

Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants.

Plant Cell Rep 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka City, Shizuoka, 422-8526, Japan.

Key Message: A key module, secretory component (SC), was efficiently expressed in Arabidopsis thaliana. The plant-based SC and immunoglobulin A of animal or plant origin formed secretory IgA that maintains antigen-binding activity. Plant expression systems are suitable for scalable and cost-effective production of biologics. Read More

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November 2018

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case-control studies.

J Res Med Sci 2018 26;23:89. Epub 2018 Oct 26.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Saliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups.

Materials And Methods: Web of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017. Read More

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October 2018

Potential Blood Pressure Goals in IgA Nephropathy: Prevalence, Awareness, and Treatment Rates in Chronic Kidney Disease Among Patients with Hypertension in China (PATRIOTIC) Study.

Kidney Blood Press Res 2018 Nov 30;43(6):1786-1795. Epub 2018 Nov 30.

Background/aims: IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA nephropathy, our aim was to critically appraise the potential BP goal in IgA nephropathy. Read More

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November 2018

Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity.

Biol Pharm Bull 2018 ;41(12):1874-1878

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.

The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Read More

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January 2018

Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism.

Biol Pharm Bull 2018 ;41(12):1769-1777

Department of Pharmaceutical Technology, Kobe Pharmaceutical University.

We reported a novel transport mechanism of curcumin, independent of improved solubility, which involved direct contact of amorphous solid particles with the cell membrane. This mechanism has potential as a novel systemic delivery system of poorly water-soluble drugs. In this study, the transport mechanism of furosemide (FUR), which is transported by the same novel mechanism, was examined. Read More

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January 2018

Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):88-96

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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November 2018

Treatment approach for the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a European hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):83-87

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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November 2018

Chylomicron mimicking solid lipid nanoemulsions encapsulated enteric minicapsules targeted to colon for immunization against hepatitis B.

Int Immunopharmacol 2018 Nov 29;66:317-329. Epub 2018 Nov 29.

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, CG 495009, India. Electronic address:

The oral route is one of the most convenient routes for drug and/or vaccine delivery. Yet variable nature of gastrointestinal tract due to transient changes in pH, physiology, and flora throughout the gut together with hostile nature of peptide drugs/vaccines when given by this route results in limited success. Colon targeting is a recent area of interest for most of the research among which hard gelatin coated capsules is one such important and useful contrivance. Read More

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November 2018
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Early-Life Formation of the Microbial and Immunological Environment of the Human Airways.

Cell Host Microbe 2018 Nov 19. Epub 2018 Nov 19.

Service de Pneumologie, Centre Hospitalier Universitaire Vaudois (CHUV), 1066 Epalinges, Switzerland; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. Read More

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November 2018
2 Reads

Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection.

Vet Parasitol 2018 Dec 22;264:18-25. Epub 2018 Oct 22.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom; Department of Animal, Plant and Soil Sciences, AgriBio, 5 Ring Road, Bundoora, Victoria 3086, Melbourne, Australia.

Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Read More

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December 2018

Influence of Dietary Copper Methionine Concentrations on Growth Performance, Digestibility of Nutrients, Serum Lipid Profiles, and Immune Defenses in Broilers.

Biol Trace Elem Res 2018 Dec 4. Epub 2018 Dec 4.

College of Animal Science, Anhui Science and Technology University, Bengbu, 233100, China.

A 42-day experiment was conducted to evaluate the influence of dietary copper (Cu) concentrations on growth performance, nutrient digestibility, and serum parameters in broilers aged from 1 to 42 days. Five hundred forty 1-day-old broilers were randomly assigned into 1 of the following 6 dietary treatments: (1) control (basal diet without supplemental Cu), (2) 15 mg/kg supplemental Cu (Cu15), (3) 30 mg/kg supplemental Cu (Cu30), (4) 60 mg/kg supplemental Cu (Cu60), (5) 120 mg/kg supplemental Cu (Cu120), and (6) 240 mg/kg supplemental Cu (Cu240), Cu as copper methionine. A 4-day metabolism trial was conducted during the last week of the experiment feeding. Read More

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December 2018

Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced by Tumor-Infiltrating B Cells in Breast Cancer.

Front Immunol 2018 20;9:2660. Epub 2018 Nov 20.

Cancer Biomarker and Immunotherapy Group, Latvian Biomedical Research and Study Centre, Riga, Latvia.

An important role for tumor infiltrating B lymphocytes (TIL-B) in the immune response to cancer is emerging; however, very little is known about the antigen specificity of antibodies produced . The presence of IgA antibodies in the tumor microenvironment has been noted although their biological functions and clinical significance are unknown. This study used a 91-antigen microarray to examine the IgG and IgA autoantibody repertoires in breast cancer (BC). Read More

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November 2018
1 Read

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies.

Medicina (Kaunas) 2018 Dec 3;54(6). Epub 2018 Dec 3.

Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. Read More

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December 2018

MEFV gene variants in children with Henoch-Schönlein Purpura and association with clinical manifestations: a single center Mediterranean experience.

Postgrad Med 2018 Dec 4. Epub 2018 Dec 4.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch Schönlein Purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without FMF symptoms and followed for at least 6 months. Read More

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December 2018

Structures of endo-1,5-α-L-arabinanase mutants from Bacillus thermodenitrificans TS-3 in complex with arabino-oligosaccharides.

Acta Crystallogr F Struct Biol Commun 2018 Dec 26;74(Pt 12):774-780. Epub 2018 Nov 26.

Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

The thermostable endo-1,5-α-L-arabinanase from Bacillus thermodenitrificans TS-3 (ABN-TS) hydrolyzes the α-1,5-L-arabinofuranoside linkages of arabinan. In this study, the crystal structures of inactive ABN-TS mutants, D27A and D147N, were determined in complex with arabino-oligosaccharides. The crystal structures revealed that ABN-TS has at least six subsites in the deep V-shaped cleft formed across one face of the propeller structure. Read More

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December 2018
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Drug-induced linear IgA bullous dermatosis: a French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis (LABD) is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs, highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

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December 2018
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Recurrent glomerulonephritis following renal transplantation and impact on graft survival.

BMC Nephrol 2018 Dec 3;19(1):344. Epub 2018 Dec 3.

Department of Renal Medicine, The Canberra Hospital, PO Box 11, Woden, Canberra, ACT 2605, Australia.

Background: Recurrence of primary glomerulonephritis in the post-transplant period has been described in the literature but the risk remains poorly quantified and its impact on allograft outcomes and implications for subsequent transplants remain under-examined. Here we describe the rates and timing of post-transplant glomerulonephritis recurrence for IgA nephropathy, focal segmental glomerulosclerosis, mesangiocapillary GN and membranous GN based on 28 years of ANZDATA registry transplant data.

Methods: We investigated the rates of GN recurrence and subsequent graft outcomes in 7236 patient from 28 years of ANZDATA transplant registry data. Read More

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December 2018
3 Reads

IgA targeting on the α-molecular recognition element (α-MoRE) of viral phosphoprotein inhibits measles virus replication by interrupting formation and function of P-N complex intracellularly.

Antiviral Res 2018 Nov 27. Epub 2018 Nov 27.

Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China. Electronic address:

Secretory IgA (SIgA) antibody is unique for its capability to transit through epithelial cells by transcytosis and thus has opportunities and probabilities to interact with all viral components during viral replication which may result in the inhibition of viral replication intracellularly. Here, we report a novel IgA mAb 1D11-IgA against phosphoprotein (P) of measles virus (MV), which is able to interact specifically with P in MV infected Vero-pIgR cells grown in a two-chamber transwell system. The binding epitope of 1D11-IgA involves a key residue proline 23 in P protein, which is among the α-molecular recognition element (α-MoRE) of P and critical for N-P complex. Read More

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November 2018

Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram.

Prostate 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Genome Integrity, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

Background: Castration-resistant prostate cancer (PCa) represents a serious health challenge. Based on mechanistically-supported rationale we explored new therapeutic options based on clinically available drugs with anticancer effects, including inhibitors of PARP1 enzyme (PARPi), and histone deacetylases (vorinostat), respectively, and disulfiram (DSF, known as alcohol-abuse drug Antabuse) and its copper-chelating metabolite CuET that inhibit protein turnover.

Methods: Drugs and their combination with ionizing radiation (IR) were tested in various cytotoxicity assays in three human PCa cell lines including radio-resistant stem-cell like derived cells. Read More

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November 2018

The inflammatory function of human IgA.

Cell Mol Life Sci 2018 Nov 29. Epub 2018 Nov 29.

Amsterdam Rheumatology and immunology Center, Academic Medical Center (AMC), Amsterdam, The Netherlands.

The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also able to actively contribute to the initiation of inflammation, both at mucosal and non-mucosal sites. This additional function of IgA is initiated by the formation of immune complexes, which trigger Fc alpha Receptor I (FcαRI) to synergize with various other receptors to amplify inflammatory responses. Read More

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November 2018
2 Reads

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children.

Acta Otorhinolaryngol Ital 2018 Oct;38(5):431-438

Department of Paediatrics, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, University Hospital, Martin, Slovakia.

Exposure to tobacco smoke is associated with a higher risk of respiratory tract diseases. The aim of this study was to determine the influence of passive smoking on selected characteristics of children with adenoid hypertrophy. Sixty-one children with adenoid hypertrophy were enrolled in the prospective study. Read More

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October 2018

Oral co-administration of a bacterial protease inhibitor in the vaccine formulation increases antigen delivery at the intestinal epithelial barrier.

J Control Release 2018 Nov 26. Epub 2018 Nov 26.

Instituto de Investigaciones Biotecnológicas (UNSAM-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina. Electronic address:

The study of capture and processing of antigens (Ags) by intestinal epithelial cells is very important for development of new oral administration systems. Efficient oral Ag delivery systems must resist enzymatic degradation by gastric and intestinal proteases and deliver the Ag across biological barriers. The recombinant unlipidated outer membrane protein from Brucella spp. Read More

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November 2018
2 Reads

B-cell homeostasis is maintained during long duration spaceflight.

J Appl Physiol (1985) 2018 Nov 29. Epub 2018 Nov 29.

Department of Health, The University of Bath, United Kingdom.

Long duration spaceflights reportedly induce immune dysregulation, which is considered a risk to astronaut safety and mission success. Recent studies have examined the impact of spaceflight on markers of adaptive and innate immunity, but no study to date has comprehensively evaluated humoral immunity and serological markers of B-cell function. The aim of this study was to characterize changes in B-cell numbers and phenotypes, along with plasma immunoglobulins and polyclonal free light chains (FLC) - near 'real-time' biomarkers of immunoglobulin synthesis - in response to a ~6-month mission to the International Space Station (ISS). Read More

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November 2018
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Celiac Disease in Children with Chronic Diarrhoea Attending At Paediatric Gastroenterology and Nutrition Department of BSMMU.

Mymensingh Med J 2018 Oct;27(4):820-825

Dr Shohely Parveen, Medical Officer, Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

This descriptive, cross sectional study was conducted at Bangabandhu Sheikh Mujib Medical University from July 2012 to July 2015 to see the occurrence of celiac disease in children with chronic diarrhea. A total of 62 children (age <18 years) attending the Paediatric Gastroenterology and Nutrition department of BSMMU with chronic diarrhoea were enrolled for the study. Mean age of studied children was 7. Read More

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October 2018

Cardiovascular, thromboembolic and renal outcomes in IgA vasculitis (Henoch-Schönlein purpura): a retrospective cohort study using routinely collected primary care data.

Ann Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. Read More

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November 2018
1 Read

Seroprevalence and risk factors for Campylobacter jejuni seropositivity in Jordan.

Infect Dis (Lond) 2018 Nov 29:1-7. Epub 2018 Nov 29.

a Department of Veterinary Pathology and Public Health, Faculty of Veterinary Medicine , Jordan University of Science and Technology , Irbid , Jordan.

Background: This is the first large-scale cross-sectional study to examine Campylobacter jejuni seropositivity in Jordan.

Methods: A total of 368 serum samples from nine governorates of Jordan were tested for IgA and IgG antibodies using enzyme-linked immunosorbent assay along with data collection to determine and rank possible risk factors by logistic regression analyses.

Results: The results showed that the rate of seroprevalence is 13. Read More

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November 2018

New Zealand Austrophthiracarus (Acari, Oribatida, Steganacaridae): two new species from the North Island.

Zootaxa 2018 Oct 16;4500(3):443-450. Epub 2018 Oct 16.

Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, P. R. China..

Two new species of Austrophthiracarus (Oribatida: Steganacaridae) from national parks on the North Island of New Zealand are described: Austrophthiracarus taranaki sp. nov. from moss along tracks in Wilkies Pools, Egmont National Park, Taranaki and Austrophthiracarus whirinaki sp. Read More

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October 2018

Serum markers in the differential diagnosis of Waldenstrom macroglobulinemia and other IgM monoclonal gammopathies.

J Clin Lab Anal 2018 Nov 28:e22827. Epub 2018 Nov 28.

The Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.

Background: IgM monoclonal gammopathy can be present in a broad spectrum of diseases. We evaluated the value of serum markers in the differential diagnosis of Waldenstrom macroglobulinemia (WM) and other types of IgM monoclonal gammopathies.

Methods: We included patients who were first admitted to hospital and identified as having IgM monoclonal gammopathy by serum immunofixation electrophoresis (sIFE). Read More

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November 2018
1 Read

Kinetics of antigen-specific IgM/ IgG/ IgA antibody responses during Zika virus natural infection in two patients.

J Med Virol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Infectious Disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

Understanding of kinetics of antibody responses is crucial for developing rapid serological tests and studying the mechanisms of Zika virus (ZIKV) infection. Most of the serological diagnostic assays previously published are based on either IgM or IgG titer, little is known on the level of IgA antibody in saliva and urine. In this study, we investigated the kinetics of IgM/ IgG/ IgA antibody responses in serum, saliva and urine obtained from two ZIKV infected individuals from as early as the 2 day of onset of symptoms to as long as 2 years post infection. Read More

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November 2018

Effects of Bacillus subtilis C-3102 on production, hatching performance, egg quality, serum antioxidant capacity and immune response of laying breeders.

J Anim Physiol Anim Nutr (Berl) 2018 Nov 28. Epub 2018 Nov 28.

Hunan Songyun Commercial Fowl Company, Huaihua, China.

To investigate the supplemental effects of Bacillus subtilis C-3102 on the production, hatching performance, egg quality, serum antioxidant capacity and immune response of laying breeders, a total of 480 Xuefeng black-bone (25-week-old) hens were randomly assigned into four treatment groups: Hens fed the basal diets with 0 (CON), 3.0 × 10 (BS-1), 6.0 × 10  cfu/g (BS-2) and 9. Read More

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November 2018
3 Reads

Gait parameters in children with bilateral spastic cerebral palsy: a systematic review of randomized controlled trials.

Dev Med Child Neurol 2018 Nov 28. Epub 2018 Nov 28.

Institut Guttmann, Neurorehabilitation Institute, Badalona, Spain.

Aim: To identify the gait parameters used to assess gait disorders in children with bilateral spastic cerebral palsy (CP) and evaluate their responsiveness to treatments.

Method: A systematic search within PubMed, Web of Science, and Scopus (in English, 2000-2016) for randomized controlled trials of children with bilateral spastic CP who were assessed by instrumented gait analysis (IGA) was performed. Data related to participants and study characteristics, risk of bias, and outcome measures were collected. Read More

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November 2018
1 Read

Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study.

Ren Fail 2018 Nov;40(1):657-664

a Kidney Disease Centre, The First Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Background: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years.

Methods And Results: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled. Read More

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November 2018
1 Read

Quality of life in celiac disease and the effect of gluten-free diet.

JGH Open 2018 Aug 6;2(4):124-128. Epub 2018 Jun 6.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Patients with celiac disease (CD) have a poor health-related quality of life (HR-QOL). We assessed the QOL in patients with CD using both generic (SF-12) and specific (CD-QOL) questionnaires, and the effect of gluten-free diet (GFD) on HR-QOL.

Methods: We conducted a prospective follow-up study based on consecutive patients of suspected CD between June 2014 and November 2015. Read More

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August 2018
3 Reads

Pentraxins and Fc Receptor-Mediated Immune Responses.

Front Immunol 2018 13;9:2607. Epub 2018 Nov 13.

Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.

C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago. Mammalian pentraxins are characterized by the presence of five identical non-covalently linked subunits. Read More

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November 2018
3 Reads

Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: a single-center experience in Japan.

Transpl Infect Dis 2018 Nov 27:e13033. Epub 2018 Nov 27.

Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.

Background: Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital.

Methods: Our cross-sectional study included 184 kidney transplant recipients. Read More

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November 2018
1 Read

Immunogenicity and viral shedding of Russian-backbone seasonal trivalent, live-attenuated influenza vaccine in a phase II randomized placebo-controlled trial among pre-school aged children in urban Bangladesh.

Clin Infect Dis 2018 Nov 27. Epub 2018 Nov 27.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD.

Introduction: We evaluated Russian-backbone, live-attenuated influenza vaccine (LAIV) for immunogenicity and viral shedding in a phase 2, randomized, placebo-controlled trial among Bangladeshi children.

Materials And Methods: Healthy children received a single, intranasal dose of LAIV containing the 2011-2012 WHO recommended formulation or placebo (clinicaltrials.gov # NCT01625689). Read More

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November 2018
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The effect of pre-existing immunity on virus detection and immune responses in a phase II randomized trial of a Russian-backbone live attenuated influenza vaccine in Bangladeshi children.

Clin Infect Dis 2018 Nov 27. Epub 2018 Nov 27.

Department of International Health, Johns Hopkins University, Baltimore, Maryland, USA.

Background: In a 2012 phase II clinical trial (NCT01625689), 300 Bangladeshi children aged 24 to 59 months with no prior influenza vaccine exposure were randomized to receive a single dose of intra-nasally administered trivalent Russian-backbone live attenuated influenza vaccine (LAIV) or placebo. Protocol-defined analyses, presented in the companion manuscript, demonstrate decreased viral detection and immunogenicity for A/H1N1pdm09 relative to the A/H3N2 and B strains. This post-hoc analysis of the trial data aims to investigate the LAIV strain differences by testing the hypothesis that pre-existing immunity may influence viral recovery and immune responses after LAIV receipt. Read More

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November 2018

Subclinical oral involvement in patients with endemic pemphigus foliaceus.

Dermatol Pract Concept 2018 Oct 31;8(4):252-261. Epub 2018 Oct 31.

School of Dentistry, University of Antioquia, Medellin, Colombia.

Background: We have described a variant of endemic pemphigus foliaceus (EPF) in El Bagre area known as pemphigus Abreu-Manu. Our previous study suggested that Colombian EPF seemed to react with various plakin family proteins, such as desmoplakins, envoplakin, periplakin BP230, MYZAP, ARVCF, p0071 as well as desmoglein 1.

Objectives: To explore whether patients affected by a new variant of endemic pemphigus foliaceus (El Bagre-EPF) demonstrated oral involvement. Read More

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October 2018
2 Reads

Effects of chocolate containing strain NTM048 on immune function: a randomized, double-blind, placebo-controlled trial.

Immun Ageing 2018 20;15:29. Epub 2018 Nov 20.

3Institute for Health and Life Science, Tokyo Medical & Dental University, 3-10, Kandasurugadai 10-chome, Chiyoda-ku, Tokyo, 101-0062 Japan.

Background: Previous reports showed that oral administration of strain NTM048 increases IgA levels and CD4+ T cell population in feces and mice, respectively, as revealed by flow cytometric analysis of splenocytes. This study aimed to evaluate the effect of chocolate supplemented with strain NTM048 (> 1.00 × 10 CFU/day, NTM048) on the immune parameters of healthy subjects, using a randomized, placebo-controlled, double-blinded study design. Read More

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November 2018
2 Reads

IgA deposition in a vegetating plaque on the glans penis: a diagnostic dilemma.

Int J Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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November 2018
1 Read

Inflammation is correlated with severity and outcome of cerebral venous thrombosis.

J Neuroinflammation 2018 Nov 26;15(1):329. Epub 2018 Nov 26.

Neurosurgery Department of Xuanwu Hospital Capital Medical University, Changchun st 45, Xicheng District, Beijing, China.

Background: Few studies have suggested a relationship between inflammation and cerebral venous thrombosis (CVT). This retrospective study aimed to explore the changes in inflammation in different CVT stages and the correlation between inflammation and severity and outcome of CVT.

Methods: In total, 95 suitable patients with CVT and 41 controls were compared. Read More

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November 2018
8 Reads

Mouse intestinal microbiota reduction favors local intestinal immunity triggered by antigens displayed in Bacillus subtilis biofilm.

Microb Cell Fact 2018 Nov 26;17(1):187. Epub 2018 Nov 26.

Institute of Virology, University of Zurich, Winterthurerstrasse 266a, 8057, Zurich, Switzerland.

Background: We previously engineered Bacillus subtilis to express an antigen of interest fused to TasA in a biofilm. B. subtilis has several properties such as sporulation, biofilm formation and probiotic ability that were used for the oral application of recombinant spores harboring Echinococcus granulosus paramyosin and tropomyosin immunogenic peptides that resulted in the elicitation of a specific humoral immune response in a dog model. Read More

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November 2018
3 Reads

Towards a personalized treatment for IgA nephropathy considering pathology and pathogenesis.

Authors:
Rosanna Coppo

Nephrol Dial Transplant 2018 Nov 26. Epub 2018 Nov 26.

Fondazione Ricerca Molinette, Regina Margherita Hospital, Turin, Italy.

The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care. However, proteinuria in IgAN may result not only from active lesions but also from sclerotic glomerular lesions with hyperfiltration and tubular damage. Read More

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November 2018
4 Reads