8,643 results match your criteria IgA Nephropathy


APRIL increase precedes IgA nephropathy recurrence in kidney transplant recipients.

Clin Transplant 2019 Feb 18:e13502. Epub 2019 Feb 18.

Nephrology Service, Universitary Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.

Background: IgA nephropathy (IgAN) may recur in kidney transplant recipients. B-cell activating factor (BAFF), proliferation-inducing-ligand (APRIL) and α-defensins are involved in the pathogenesis of native IgAN, however, their role on IgAN recurrence has not been previously analyzed.

Methods: 35 patients with IgAN who received a kidney transplant in our center between 1/Jan/1993 and 31/Dec/2015 were included. Read More

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http://dx.doi.org/10.1111/ctr.13502DOI Listing
February 2019

Ravulizumab: First Global Approval.

Authors:
Kate McKeage

Drugs 2019 Feb 14. Epub 2019 Feb 14.

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Ravulizumab (ravulizumab-cwvz; ULTOMIRIS™), a humanized monoclonal antibody, is a complement C5 inhibitor developed by Alexion Pharmaceuticals for the treatment of paroxysmal nocturnal haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS). Like the first-generation C5 inhibitor, eculizumab, ravulizumab binds specifically and with high affinity to the complement protein C5, thereby preventing formation of the terminal complement complex C5b-9, which mediates cell lysis. In December 2018, intravenous ravulizumab received its first global approval in the USA for the treatment of adults with PNH, and is under regulatory review in the European Union and Japan in this indication. Read More

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http://link.springer.com/10.1007/s40265-019-01068-2
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http://dx.doi.org/10.1007/s40265-019-01068-2DOI Listing
February 2019
1 Read

Structural prediction of antibody-APRIL complexes by computational docking constrained by antigen saturation mutagenesis library data.

J Mol Recognit 2019 Feb 13:e2778. Epub 2019 Feb 13.

Visterra, Inc., Waltham, MA, USA.

IgA nephropathy (IgAN) is the most prevalent cause of primary glomerular disease worldwide, and the cytokine A PRoliferation-Inducing Ligand (APRIL) is emerging as a key player in IgAN pathogenesis and disease progression. For a panel of anti-human APRIL antibodies with known antagonistic activity, we sought to define their structural mode of engagement to understand molecular mechanisms of action and aid rational antibody engineering. Reliable computational prediction of antibody-antigen complexes remains challenging, and experimental methods such as X-ray co-crystallography and cryoEM have considerable technical, resource, and throughput barriers. Read More

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http://dx.doi.org/10.1002/jmr.2778DOI Listing
February 2019

IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2.

Glycobiology 2019 Jan 31. Epub 2019 Jan 31.

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL.

GalNAc-type O-glycans are often added to proteins post-translationally in a clustered manner in repeat regions of proteins, such as mucins and IgA1. Observed IgA1 glycosylation patterns show that glycans occur at similar sites with similar structures. It is not clear how the sites and number of glycans added to IgA1, or other proteins, can follow a conservative process. Read More

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http://dx.doi.org/10.1093/glycob/cwz007DOI Listing
January 2019

New strategies and perspectives on managing IgA nephropathy.

Clin Exp Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 9HN, UK.

IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in the glomerular mesangium and is the most commonly reported primary glomerulonephritis worldwide. Thirty to forty percent of patients with the disease develop progressive renal function decline, requiring renal replacement therapy within two decades of diagnosis. Despite this, accurate individual risk stratification at diagnosis and predicting treatment response remains a challenge. Read More

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http://dx.doi.org/10.1007/s10157-019-01700-1DOI Listing
February 2019

The spectrum of kidney biopsy findings in patients with morbid obesity.

Kidney Int 2019 Jan 26. Epub 2019 Jan 26.

Department of Pathology and Cell Biology, Division of Renal Pathology, Columbia University Medical Center, New York, New York, USA. Electronic address:

Morbid obesity, defined as body mass index (BMI) ≥40 kg/m, affects approximately 8% of United States adults and is a recognized risk factor for chronic kidney disease (CKD). We present the first focused biopsy-based study exploring the range of kidney diseases in this population. Among 3263 native kidney biopsies interpreted at Columbia University in 2017, we identified 248 biopsies from morbidly obese patients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.026DOI Listing
January 2019
1 Read

The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation.

BMC Nephrol 2019 Jan 31;20(1):33. Epub 2019 Jan 31.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation.

Methods: This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy. Read More

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http://dx.doi.org/10.1186/s12882-019-1222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357388PMC
January 2019
1 Read

From Schönlein-Henoch purpura to IgA-vasculitis: pathogenetic aspects of the disease.

Ter Arkh 2018 Nov;90(10):109-114

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Investigation's history and nomenclature's evolution of the IgA-vasculitis are presented in the article. Pathogenesis of the renal and skin damages is discussed in details, particularly abnormalities of the IgA-immunity and systemic endotoxemia. Relevant world's literature is cited. Read More

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http://dx.doi.org/10.26442/terarkh20189010109-114DOI Listing
November 2018
2 Reads

A case of IgA nephropathy with deep venous thrombosis in the mesentery and lower extremities.

Quant Imaging Med Surg 2018 Dec;8(11):1123-1128

Department of Imaging, The Second People's Hospital of Wuxi, Wuxi 214002, China.

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http://dx.doi.org/10.21037/qims.2018.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328382PMC
December 2018
1 Read

Podocytopathy in the mesangial proliferative immunoglobulin A nephropathy: new insights into the mechanisms of damage and progression.

Nephrol Dial Transplant 2019 Jan 29. Epub 2019 Jan 29.

Fondazione Ricerca Molinette, Regina Margherita Hospital, Turin, Italy.

Immunoglobulin A nephropathy (IgAN) was defined as a mesangiopathic disease, since the primary site of deposition of IgA immune material is the mesangium, and proliferation of mesangial cells and matrix excess deposition are the first histopathologic lesions. However, the relentless silent progression of IgAN is mostly due to the development of persistent proteinuria, and recent studies indicate that a major role is played by previous damage of function and anatomy of podocytes. In IgAN, the podocytopathic changes are the consequence of initial alterations in the mesangial area with accumulation of IgA containing immune material. Read More

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http://dx.doi.org/10.1093/ndt/gfy413DOI Listing
January 2019
2 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
2 Reads

The role of phosphorylcholine-specific immune responses in the tonsils and peripheral blood on IgA nephropathy.

Acta Otolaryngol 2018 Dec 25;138(12):1099-1104. Epub 2019 Jan 25.

a Department of Otolaryngology, Head and Neck Surgery , Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.

Background: Tonsillectomy combined with steroid pulse therapy was reported to be effective for patients with IgA nephropathy. However, the mechanisms of the effect of tonsillectomy on IgA nephropathy are unknown.

Aim: The aim of this study was to investigate the involvement of the phosphorylcholine (PC)-specific immune response in the tonsils and peripheral blood of patients with IgA nephropathy. Read More

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https://www.tandfonline.com/doi/full/10.1080/00016489.2018.1
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http://dx.doi.org/10.1080/00016489.2018.1522450DOI Listing
December 2018
4 Reads

Analysis of the relationship between Oxford classification, IgM deposition and multiple indexes and the adverse prognosis of patients with primary IgA nephropathy and related risk factors.

Exp Ther Med 2019 Feb 5;17(2):1234-1239. Epub 2018 Dec 5.

Division of Nephrology, Kidney Research Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.

The risk and influencing factors of prognosis in patients with primary IgA nephropathy (IgAN) were explored. One hundred and twenty-four patients who were diagnosed with IgA nephropathy in West China Hospital of Sichuan University were selected as the study subjects. The baseline data were recorded. Read More

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http://dx.doi.org/10.3892/etm.2018.7050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327417PMC
February 2019
1 Read

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
2 Reads

Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis.

Rheumatol Int 2019 Mar 23;39(3):561-567. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.

The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria. Read More

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http://link.springer.com/10.1007/s00296-019-04241-8
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http://dx.doi.org/10.1007/s00296-019-04241-8DOI Listing
March 2019
5 Reads

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Pathology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14000, Mexico.

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Read More

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http://www.mdpi.com/2077-0383/8/1/114
Publisher Site
http://dx.doi.org/10.3390/jcm8010114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352144PMC
January 2019
7 Reads

Tonsillectomy plus steroid pulse therapy is the most effective treatment in adult patients with C-Grade I IgA nephropathy, and the weight of the extracted palatine tonsils and Yamamoto scale have no significant correlation with the effects of this treatment.

Auris Nasus Larynx 2019 Jan 18. Epub 2019 Jan 18.

Department of Otolaryngology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Objective: We studied patients who underwent tonsillectomy plus steroid pulse therapy (TSP) for immunoglobulin A nephropathy (IgAN), in order to investigate the clinical factors associated with a positive response to this treatment.

Methods: We analyzed 118 IgAN patients who underwent TSP. We collected patients' data retrospectively, including age, sex, blood pressure, onset of IgAN, pathological findings of a renal biopsy, serum concentration of creatinine, estimated glomerular filtration rate, serum concentration of protein, urinary protein, hematuria, past history of tonsillitis, the Yamamoto scale, the weight and pathological findings of the extracted palatine tonsils, and the presence or absence of anti-platelet drugs and renin-angiotensin system inhibitors (RAS-I) usage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183087
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http://dx.doi.org/10.1016/j.anl.2019.01.003DOI Listing
January 2019
5 Reads

Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Feb;95(2):268-280

Division of Nephrology, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. The conference focused on the 2012 KDIGO guideline with the aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, in particular, therapy of glomerular diseases since the guideline's publication. It was the consensus of the group that most guideline recommendations, in particular those dealing with therapy, will need to be revisited by the guideline-updating Work Group. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.018DOI Listing
February 2019
2 Reads

Changes in primary glomerulonephritis in Singapore over four decades
.

Clin Nephrol 2019 Jan 21. Epub 2019 Jan 21.

This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1 decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2 decade, the percentage of mesangial proliferative GN decreased, but membranous GN became more common, as was seen in China and Thailand. Read More

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http://dx.doi.org/10.5414/CN109577DOI Listing
January 2019
8 Reads

Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury.

Kidney Int 2019 Jan 16. Epub 2019 Jan 16.

Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

Tubular injury and interstitial fibrosis are the hallmarks of chronic kidney disease. While recent studies have verified that proximal tubular injury triggers interstitial fibrosis, the impact of fibrosis on tubular injury and regeneration remains poorly understood. We generated a novel mouse model expressing diphtheria toxin receptor on renal fibroblasts to allow for the selective disruption of renal fibroblast function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.017DOI Listing
January 2019
1 Read

Dabigatran causing severe acute kidney injury in a patient with liver cirrhosis.

CEN Case Rep 2019 Jan 18. Epub 2019 Jan 18.

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, SAR, China.

Anticoagulant-related nephropathy (ARN), a significant but frequently undiagnosed problem in patients receiving anticoagulation, is found to be associated with increased renal morbidity and all-cause mortality. While ARN is mainly associated with warfarin use, recent case reports suggest that it may also occur in patients taking direct oral anticoagulants (DOAC). We report a patient who had a history of alcoholic liver cirrhosis and paroxysmal atrial fibrillation, and received dabigatran 110 mg twice daily for 1 year. Read More

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http://dx.doi.org/10.1007/s13730-019-00378-4DOI Listing
January 2019
2 Reads

Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

BMC Infect Dis 2019 Jan 16;19(1):57. Epub 2019 Jan 16.

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China.

Background: After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the development of HBVr combined with NS after allo-HSCT is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3690-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335709PMC
January 2019
2 Reads

Clinical and pathological factors of renal anaemia in patients with IgA nephropathy in Chinese adults: a cross-sectional study.

BMJ Open 2019 Jan 15;9(1):e023479. Epub 2019 Jan 15.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People's Republic of China.

Objective: Few studies with large sample populations concerning renal anaemia and IgA nephropathy have been reported worldwide. The purpose of this cross-sectional study was to examine the clinical and pathological characteristics and influencing factors associated with renal anaemia in patients with IgA nephropathy, which is the most common aetiology of chronic kidney disease.

Methods: A total of 462 hospitalised patients with IgA nephropathy confirmed by renal biopsy who met the inclusion criteria were consecutively recruited from January 2014 to January 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340464PMC
January 2019
2 Reads

microRNAs in chronic kidney disease.

Clin Chim Acta 2019 Jan 11;491:59-65. Epub 2019 Jan 11.

Department of Nephrology, Baoji Central Hospital, No. 8 Jiangtan Road, Baoji, Shaanxi 721008, China. Electronic address:

Chronic kidney disease (CKD) results in high morbidity and mortality worldwide causing a huge socioeconomic burden. MicroRNA (miRNA) exert critical regulatory functions by targeting downstream genes and have been associated with many pathophysiologic processes including CKD. In fact, many studies have shown that the expression of various miRNAs was significantly changed in CKD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193002
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http://dx.doi.org/10.1016/j.cca.2019.01.008DOI Listing
January 2019
5 Reads

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy.

J Formos Med Assoc 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN). C5a, a complement activation end product, is a strong inflammatory cell stimulator and can influence the behavior of T cells and dendritic cells. This study examined the etiology-disease relationship and significance of auto-antibody and C5a with short-term remission. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183073
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http://dx.doi.org/10.1016/j.jfma.2018.12.026DOI Listing
January 2019
8 Reads

Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy.

Clin J Am Soc Nephrol 2019 Jan 11. Epub 2019 Jan 11.

Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, Minnesota

IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved therapies. A challenge for evaluating treatments for IgAN is the usual long time course for progression to ESKD. The aim of this Kidney Health Initiative project was to identify surrogate end points that could serve as reliable predictors of a treatment's effect on long-term kidney outcomes in IgAN and be used as a basis for approval. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08600718
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http://dx.doi.org/10.2215/CJN.08600718DOI Listing
January 2019
5 Reads

Palmoplantar pustulosis and IgA nephropathy.

J Gen Fam Med 2019 Jan 8;20(1):35-36. Epub 2018 Nov 8.

Department of Nephrology Teine Keijinkai Medical Center Sapporo Hokkaido Japan.

We present a case of IgA nephropathy complicated with palmoplantar pustulosis. The skin lesion improved with tonsillectomy. The purposes of this article were to aid physicians in understanding that (a) IgA nephropathy should be considered in patients with palmoplantar pustulosis and (b) patients with these diseases should be referred to otolaryngology specialists for tonsillectomy. Read More

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http://dx.doi.org/10.1002/jgf2.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321824PMC
January 2019
3 Reads

Anticoagulant Related Nephropathy Induced by Dabigatran.

Case Rep Nephrol 2018 9;2018:7381505. Epub 2018 Dec 9.

Department of Medicine, University of Calgary, Canada.

We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. Read More

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http://dx.doi.org/10.1155/2018/7381505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304482PMC
December 2018
4 Reads

Plasma acylcarnitines could predict prognosis and evaluate treatment of IgA nephropathy.

Nutr Metab (Lond) 2019 8;16. Epub 2019 Jan 8.

1Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 25 South Wanping Road, Shanghai, 200032 China.

Background: Effective evaluation or prediction of therapy response could be helpful for treatment of chronic kidney disease (CKD), which may rely on accurate biomarkers. Acylcarnitines are involved with lipid metabolism and mitochondrial function. The relation of acylcarnitines with treatment response in patients with CKD is unknown. Read More

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http://dx.doi.org/10.1186/s12986-018-0328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323753PMC
January 2019
1 Read

Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice.

FASEB J 2019 Jan 10:fj201801748R. Epub 2019 Jan 10.

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan; and.

Because the association between sphingosine 1-phosphate (S1P)/apolipoprotein M (ApoM) and chronic kidney diseases has not been established, we investigated the involvement of S1P/ApoM in the phenotypes of IgA nephropathy in hyper-IgA (HIGA) mice. The overexpression of ApoM in adenoviral gene transfer ameliorated the phenotypes of IgA nephropathy in HIGA mice, whereas the knockdown of ApoM with siRNA caused deterioration. When ApoM-overexpressing HIGA mice were treated with VPC23019, an antagonist against S1P receptor 1 (S1P1) and 3 (S1P3), we observed that the protective effects of ApoM were reversed, whereas JTE013, an antagonist against S1P2, did not inhibit the effects. Read More

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http://dx.doi.org/10.1096/fj.201801748RDOI Listing
January 2019
1 Read

[Nephrology : what's new in 2018 ?]

Rev Med Suisse 2019 Jan;15(N° 632-633):69-73

Service de néphrologie, Département des spécialités médicales, HUG, 1211 Genève 14.

Major advances in the treatment of ANCA associated-renal vasculitides, IGA nephropathy and renal autosomal dominant polycystic disease were published within the past year. There is neither clear benefit of early initiation of renal replacement therapy in the intensive care unit nor with the use of chloride-poor solutions to prevent kidney failure. Maintenance parenteral iron supplementation in hemodialysis patients is neither associated with infectious nor cardiovascular risks. Read More

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January 2019
2 Reads

New findings showing how DNA methylation influences diseases.

World J Biol Chem 2019 Jan;10(1):1-6

Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari 70121, Italy.

In 1975, Holliday and Pugh as well as Riggs independently hypothesized that DNA methylation in eukaryotes could act as a hereditary regulation mechanism that influences gene expression and cell differentiation. Interest in the study of epigenetic processes has been inspired by their reversibility as well as their potentially preventable or treatable consequences. Recently, we have begun to understand that the features of DNA methylation are not the same for all cells. Read More

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https://www.wjgnet.com/1949-8454/full/v10/i1/1.htm
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http://dx.doi.org/10.4331/wjbc.v10.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314879PMC
January 2019
11 Reads

Mesangial C4d deposition is independently associated with poor renal survival in patients with primary focal segmental glomerulosclerosis.

Clin Exp Nephrol 2019 Jan 7. Epub 2019 Jan 7.

Department of Pathology, Dokuz Eylul University, Izmir, Turkey.

Background: C4d deposition is defined as the footprint of immune injury and it is associated with unfavorable renal outcomes in patients with IgA nephropathy. We searched whether mesangial C4d deposition is associated with poor renal survival in patients with primary focal segmental glomerulosclerosis (FSGS).

Methods: Biopsy specimens were stained with anti-C4d antibody. Read More

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http://dx.doi.org/10.1007/s10157-018-01688-0DOI Listing
January 2019
1 Read
1.708 Impact Factor

The clinical and pathological features of adefovir dipivoxil-related renal impairment
.

Clin Nephrol 2019 Jan 7. Epub 2019 Jan 7.

Aims: To investigate the clinicopathological features and outcomes of adefovir dipivoxil (ADV)-related renal impairment in Chinese patients.

Materials And Methods: Clinical, pathological, and follow-up data from 15 patients with ADV-related renal impairment were studied. Proximal renal tubular dysfunction (PRTD) was defined by the presence of at least two of the following four abnormalities: hypophosphatemia, hypouricemia, nondiabetic glucosuria, and proteinuria. Read More

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http://dx.doi.org/10.5414/CN109574DOI Listing
January 2019
3 Reads
1.232 Impact Factor

Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience.

J Immunother Cancer 2019 Jan 6;7(1). Epub 2019 Jan 6.

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1468, Houston, TX, 77030, USA.

Rationale & Objective: The approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents. The literature on the nephrotoxicity of CPI is limited. Here, we present cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322290PMC
January 2019
10 Reads

C4d in Native Glomerular Diseases.

Authors:
Preeti Chandra

Am J Nephrol 2019 4;49(1):81-92. Epub 2019 Jan 4.

Complement activation occurs in many glomerular diseases, the exact pathway(s) of activation has been studied in detail in some diseases but not in all. C4d is generated by the activation of classical and lectin pathways, and its presence can point to the activation of either of these pathways. This review aims to summarize the available data with regard to the deposition of glomerular C4d in native kidney biopsies in different glomerular pathologies that may be useful for future research into the role of complement activation in glomerular diseases. Read More

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http://dx.doi.org/10.1159/000496059DOI Listing
January 2019
2 Reads

IgA-Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits.

Am J Med 2019 Jan 4. Epub 2019 Jan 4.

Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193000
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http://dx.doi.org/10.1016/j.amjmed.2018.12.007DOI Listing
January 2019
4 Reads

[The 467th case: proteinuria, periungual fibromas, and facial steatadenomas].

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):74-77

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.

A 22-year-old manpresented as a refractory nephrotic syndrome with edema and proteinuria for more than one year. Physical examination revealed facial steatadenomas and periungual fibromas. Images were characterized by hamartomatous lesions in multiple organs, including the central nervous system, heart, lungs, liver, and kidneys. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.014DOI Listing
January 2019
1 Read

Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

School of Pharmacy, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, 710069, Shaanxi, China.

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1756-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317198PMC
January 2019
6 Reads
3.930 Impact Factor

Association of high body mass index with development of interstitial fibrosis in patients with IgA nephropathy.

BMC Nephrol 2018 Dec 29;19(1):381. Epub 2018 Dec 29.

Renal Department and Nephrology Institute, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32 West 2nd Duan, 1st Circle Road, Qingyang District, Chengdu, Sichuan, 610072, People's Republic of China.

Background: The worldwide prevalence of obesity is increasing. Obesity is associated with a variety of chronic diseases, including chronic kidney disease. Several studies suggested that body mass index (BMI) could be an independent risk factor for progression of IgA nephropathy (IgAN). Read More

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http://dx.doi.org/10.1186/s12882-018-1164-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310977PMC
December 2018
2 Reads
1.520 Impact Factor

Acute renal failure in a patient with PR3-ANCA and monoclonal immunoglobulin deposition disease: Case report.

Medicine (Baltimore) 2018 Dec;97(52):e13799

Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada.

Rationale: Acute renal failure developing over a short period of time with evidence of glomerular disease by urine sediment microscopy characterizes the clinical syndrome of rapidly progressive glomerulonephritis (RPGN), of which the most common causes are ANCA-associated glomerulonephritis (GN), immune-complex mediated GN and anti-GBM disease.

Patient Concerns: This was a middle-aged gentleman who presented with acute renal failure and a positive PR3-ANCA.

Diagnosis: Renal biopsy showed an unusual combination of PR3-ANCA GN with focal crescents, monoclonal immunoglobulin deposition disease (MIDD) and mesangial IgA deposition on renal biopsy. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
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http://dx.doi.org/10.1097/MD.0000000000013799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314724PMC
December 2018
3 Reads

Pattern of glomerular disease and clinicopathological correlation: A single-center study from Eastern Nepal.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1410-1416

Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

The pattern of glomerular disease varies worldwide. In the absence of kidney disease/kidney biopsy registry in Nepal, the exact etiology of different forms of glomerular disease is primarily unknown in our country. We analyzed 175 cases of renal biopsies performed from September 2014 to August 2016 in Internal Medicine Ward at B. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1410/248302
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http://dx.doi.org/10.4103/1319-2442.248302DOI Listing
December 2018
7 Reads

IgA nephropathy with diffuse alveolar haemorrhage.

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Department of Pulmonary Medicine, Yokkaichi Municipal Hospital, Yokkaichi, Japan.

Immunoglobulin (Ig)A nephropathy is the most common cause of primary glomerulonephritis worldwide. While IgA nephropathy has been associated with a variety of other diseases, pulmonary complications are extremely rare. A 58-year-old man presented with a 2-week history of fever and exertional dyspnoea. Read More

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http://dx.doi.org/10.1136/bcr-2018-227382DOI Listing
December 2018
2 Reads

A Case of Self-Limiting Crescentic Immunoglobulin A Glomerulonephritis Associated with Sternoclavicular Arthritis.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):246-252. Epub 2018 Nov 21.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Immunoglobulin (Ig) A glomerulonephritis (GN) is a heterogeneous disease affected by various factors. Genetic and other factors "hit" DNA, causing IgA malformation and ultimately glomerular injury. We describe a rare case of crescentic IgA GN with sternoclavicular (SC) arthritis in a 75-year-old woman. Read More

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https://www.karger.com/Article/FullText/494715
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http://dx.doi.org/10.1159/000494715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276760PMC
November 2018
8 Reads

Kartagener syndrome complicated by immunoglobulin A nephropathy.

Int Med Case Rep J 2018 10;11:359-362. Epub 2018 Dec 10.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan,

We herein report the case of a 36-year-old woman with Kartagener syndrome (KS), which is an autosomal recessive disorder defined by a triad of bronchiectasis, sinusitis, and situs inversus, with complications of asymptomatic microhematuria and proteinuria. She was finally diagnosed with biopsy-proven immunoglobulin (Ig) A nephropathy. KS constitutes a subgroup of primary ciliary dyskinesia (PCD) characterized by structural and/or functional ciliary abnormalities resulting in sinopulmonary involvement with varying severity. Read More

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http://dx.doi.org/10.2147/IMCRJ.S185887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292226PMC
December 2018
1 Read

Galactose-Deficient IgA1-Specific Antibody Recognizes GalNAc-Modified Unique Epitope on Hinge Region of IgA1.

Monoclon Antib Immunodiagn Immunother 2018 Dec 20;37(6):252-256. Epub 2018 Dec 20.

1 Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Galactose-deficient IgA1 (Gd-IgA1) that exposes GalNAc or sialylated GalNAc has been shown to be associated with disease activity of IgA nephropathy (IgAN). In a previous report, we established an enzyme-linked immunosorbent assay that measures human Gd-IgA1 using a specific monoclonal antibody KM55 (KM55 mAb), and showed that patients with IgAN contain a higher level of serum Gd-IgA1 than other types of renal diseases. Recently, we also found that the KM55 mAb specifically recognized the glomerular-deposited Gd-IgA1 in renal biopsy. Read More

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http://dx.doi.org/10.1089/mab.2018.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338562PMC
December 2018
1 Read

Efficacy and Safety of Agents in IgA Nephropathy: An Update Network Meta-Analysis.

Kidney Blood Press Res 2018 14;43(6):1890-1897. Epub 2018 Dec 14.

Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background/aims: The present network meta-analysis of randomized controlled trials (RCTs) was to explore the efficacy and safety of different pharmacologic interventions in IgA nephropathy with proteinuria more than 0.75 g/d.

Methods: We systematically searched the Cochrane Library, Embase, and PubMed database for studies compared the rate of clinical remission and/or serious adverse events in IgA nephropathy patients with proteinuria (> 0. Read More

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https://www.karger.com/Article/FullText/496000
Publisher Site
http://dx.doi.org/10.1159/000496000DOI Listing
December 2018
6 Reads

Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 Dec 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7911DOI Listing
December 2018
13 Reads

Difference in IgA1 O-glycosylation between IgA deposition donors and IgA nephropathy recipients.

Biochem Biophys Res Commun 2019 Jan 13;508(4):1106-1112. Epub 2018 Dec 13.

Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and disease recurrence often occurs after transplantation. On the other hands, Asymptomatic IgA deposition (IgAD) is occasionally observed in donated kidney. It is recognized that IgAD does not progress to IgAN, but the mechanism has not demonstrated yet. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.12.014DOI Listing
January 2019
1 Read