9,143 results match your criteria IgA Nephropathy


Expression of miRNA-223 and NLRP3 gene in IgA patients and intervention of traditional Chinese medicine.

Saudi J Biol Sci 2020 Jun 25;27(6):1521-1526. Epub 2020 Apr 25.

College of Life Sciences, Heilongjiang University, 74 Xuefu Road, Nangang District, Harbin City 150080, Heilongjiang Province, China.

Objective: The purpose of this study was to investigate the expression of miRNA-223 and NLRP3 in IgA patients and the intervention of traditional Chinese medicine (TCM), so as to realize the basic pathological changes of IgA patients, the expression of miRNA-223 and NLRP3 in IgA patients and the changes of patients' body indexes before and after the treatment of TCM.

Methods: Firstly, according to the clinical data, patients with IgA nephropathy were divided into different groups according to their pathological changes. After that, the chemical sections and staining steps of the immune kidney were carried out. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254046PMC

IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-κB/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1.

J Immunol 2020 Jun 1. Epub 2020 Jun 1.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan;

IgA nephropathy (IgAN), the most common primary glomerular disorder, has a relatively poor prognosis yet lacks a pathogenesis-based treatment. Compound K (CK) is a major absorbable intestinal bacterial metabolite of ginsenosides, which are bioactive components of ginseng. The present study revealed promising therapeutic effects of CK in two complementary IgAN models: a passively induced one developed by repeated injections of IgA immune complexes and a spontaneously occurring model of spontaneous grouped ddY mice. Read More

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http://dx.doi.org/10.4049/jimmunol.1900284DOI Listing

Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report.

Medicine (Baltimore) 2020 May;99(21):e20464

Department of Nephrology, Rheumatology, Endocrinology and Metabolism.

Introduction: Immune checkpoint inhibitors including nivolumab, an antibody against programmed death-1, have been increasingly introduced in various cancer treatment regimens, and are reported to be associated with immune-related adverse events. Nivolumab-induced renal injury is generally caused by acute interstitial nephritis and is managed by drug discontinuation and steroid therapy. Although this agent can infrequently induce glomerulonephritis, the pathogenesis and therapeutic strategy remain undetermined. Read More

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http://dx.doi.org/10.1097/MD.0000000000020464DOI Listing

Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy.

Clin Immunol 2020 May 29:108483. Epub 2020 May 29.

Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China. Electronic address:

Background: Immunoglobulin A nephropathy (IgAN nephropathy, IgAN) is named for the renal pathological features of IgA-dominant immunoglobulin deposition. IgA deposits, however, may also occur in other diseases, from liver disease and inflammation to chronic infections and tumors. Now increasing studies have suggested that galactose-deficient IgA1 (Gd-IgA1) plays a critical role in the pathogenesis of IgAN. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108483DOI Listing

B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease.

Clin Immunol 2020 May 29:108488. Epub 2020 May 29.

Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Laiko Hospital, Athens, Greece. Electronic address:

B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idiopathic membranoproliferative glomerulonephritis, 0/4 pauci-immune vasculitis) and 17% of control patients with renal cancer. In multivariate analysis, oligoclonal B-cells were associated with podocyte injury and the grade of glomerulosclerosis (both p = . Read More

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http://dx.doi.org/10.1016/j.clim.2020.108488DOI Listing

Artificial intelligence and machine learning in nephropathology.

Kidney Int 2020 Apr 1. Epub 2020 Apr 1.

Department of Electrical and Computer Engineering, University of Houston, Houston, Texas, USA.

Artificial intelligence (AI) for the purpose of this review is an umbrella term for technologies emulating a nephropathologist's ability to extract information on diagnosis, prognosis, and therapy responsiveness from native or transplant kidney biopsies. Although AI can be used to analyze a wide variety of biopsy-related data, this review focuses on whole slide images traditionally used in nephropathology. AI applications in nephropathology have recently become available through several advancing technologies, including (i) widespread introduction of glass slide scanners, (ii) data servers in pathology departments worldwide, and (iii) through greatly improved computer hardware to enable AI training. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.027DOI Listing

A Rare Clinical Presentation of Metastatic Crohn's Disease.

Cureus 2020 May 26;12(5):e8285. Epub 2020 May 26.

Dermatology, Baylor College of Medicine, Houston, USA.

A 31-year-old female with a history of systemic lupus erythematous, IgA nephropathy, and psoriasis presented with a one-month history of a painful, pruritic rash under the bilateral breasts and in the genital region. Cutaneous examination revealed a large, tender ulcer under the left breast with a shiny erythematous base and peripheral hypertrophic changes. Small ulcers were present on the bilateral inguinal folds, and the labia majora were edematous with multiple erythematous papules. Read More

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http://dx.doi.org/10.7759/cureus.8285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250390PMC

Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool.

Kidney Int 2020 May 25. Epub 2020 May 25.

University of Toronto, Division of Nephrology, Toronto, Canada. Electronic address:

Immunosuppression in IgA nephropathy (IgAN) should be reserved for patients at high-risk of disease progression, which KDIGO guidelines determine based solely on proteinuria 1g or more/day. To investigate if treatment decisions can be more accurately accomplished using individualized risk from the International IgAN Prediction Tool, we simulated allocation of a hypothetical immunosuppression therapy in an international cohort of adults with IgAN. Two decision rules for treatment were applied based on proteinuria 1g or more/day or predicted risk from the Prediction Tool above a threshold probability. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.042DOI Listing

Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study.

Diagn Pathol 2020 May 27;15(1):62. Epub 2020 May 27.

Université de Tours, PRES Centre-Val de Loire, Tours, France.

Background: Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it is increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially in Europe. We aimed to assess the clinical, pathologic and outcome data of IRGN-IgA. Read More

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http://dx.doi.org/10.1186/s13000-020-00980-6DOI Listing

After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy.

Kidney Int 2020 May 22. Epub 2020 May 22.

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany;. Electronic address:

The randomized, controlled STOP-IgAN trial in patients with IgA nephropathy (IgAN) and substantial proteinuria showed no benefit of immunosuppression added on top of supportive care on renal function over three years. As a follow-up we evaluated renal outcomes in patients over a follow-up of up to ten years in terms of serum creatinine, proteinuria, end-stage kidney disease (ESKD), and death. The adapted primary endpoint was the time to first occurrence of a composite of death, ESKD, or a decline of over 40% in the estimated glomerular filtration rate (eGFR) compared to baseline at randomization into STOP-IgAN. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.046DOI Listing

Inguinal Herniation After Living Donor Kidney Transplantation: A Case Report.

Transplant Proc 2020 May 21. Epub 2020 May 21.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

A 68-year-old male patient received a living donor kidney transplantation 8 years earlier for end-stage kidney disease secondary to IgA nephropathy. His post-transplantation follow-up had been routinely performed with laboratory examinations, ultrasound, and computed tomography (CT). His kidney graft function had been excellent and stable, as shown by a baseline serum creatinine level of 1. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.131DOI Listing

Treatment for IgA nephropathy with stage 3 or 4 chronic kidney disease: low-dose corticosteroids combined with oral cyclophosphamide.

J Nephrol 2020 May 23. Epub 2020 May 23.

Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, Shaanxi Province, China.

Background: The use of immunosuppressive therapy for IgA nephropathy patients with renal insufficiency and severe proteinuria is controversial.

Methods: This was a monocentric retrospective study. We reviewed 132 consecutive IgA nephropathy (IgAN) patients with stage 3 or 4 chronic kidney disease and proteinuria ≥ 1. Read More

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http://dx.doi.org/10.1007/s40620-020-00752-xDOI Listing

Clinical and histological differences between adults and children in new onset IgA nephropathy.

Pediatr Nephrol 2020 May 22. Epub 2020 May 22.

Centre de néphrologie et transplantation rénale, APHM, Hôpital Universitaire de la Conception, 147 Bd Baille, 13385, Marseille, France.

Background: Previous reports suggest initial presentation of IgA nephropathy (IgAN) in children is different from adults. No systematic comparison of clinical, biological, and histological childhood- and adult-onset IgAN is currently available.

Methods: We compared pediatric and adult clinical and histological characteristics at IgAN diagnosis. Read More

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http://dx.doi.org/10.1007/s00467-020-04614-3DOI Listing

Eosinophilic fasciitis associated with generalized morphea and IgA nephropathy.

Dermatol Ther 2020 May 22:e13641. Epub 2020 May 22.

Department of Rheumatology,PLA General Hospital, Beijing, China.

Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by increased peripheral blood eosinophils and diffuse fasciitis, generalized morphea (GM) is a subtype of localized scleroderma, and IgA nephropathy is a chronic glomerulonephritis caused by abnormal deposition of IgA in the mesangial area of the glomeruli. We describe a 49-year-old male patient with hard skin, cutaneous hyperpigmentation, and proteinuria. The patient had suffered from a long disease course of hard skin, while urine protein was newly detected. Read More

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http://dx.doi.org/10.1111/dth.13641DOI Listing

Arteriolar C4d in IgA Nephropathy: A Cohort Study.

Am J Kidney Dis 2020 May 18. Epub 2020 May 18.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Rationale & Objective: Glomerular C4d (C4dG) as an indicator of lectin pathway of complement activation in IgA nephropathy (IgAN) has been associated with more severe kidney damage. Recent studies have suggested that vascular lesions in IgAN biopsies with complement deposition are also associated with disease progression. We aimed to study the clinical significance of arteriolar C4d (C4dA) in IgAN kidney biopsy tissue. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.017DOI Listing

The consequences of altered microbiota in immune-related chronic kidney disease.

Nephrol Dial Transplant 2020 May 21. Epub 2020 May 21.

Division of Nephrology and Hypertension, University of California Irvine, Orange, CA, USA.

The normal gut microbiome modulates host enterocyte metabolism and shapes local and systemic immunity. Accumulation of urea and other waste products in chronic kidney disease induces gut dysbiosis and intestinal wall inflammation (leaky gut). There are decreased numbers of bacteria that generate short-chain fatty acids, which are an important nutrient source for host enterocytes and also contribute to regulation of the host immune system. Read More

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http://dx.doi.org/10.1093/ndt/gfaa087DOI Listing

A rare association of infection of kidney and urinary tract with immunoglobulin A nephropathy.

Indian J Med Microbiol 2019 Oct-Dec;37(4):587-589

Department of Nephrology, Madras Medical Mission, Chennai, Tamil Nadu, India.

Mycobacterium tuberculosis(MTB)-related secondary immunoglobulin A (IgA) nephropathy is reported in a 72-year-old male patient. The patient was diagnosed to have MTB infection of the kidney and genitourinary tract which was diagnosed by the demonstration of the organism by GeneXpert Ultra and culture. Concurrent kidney biopsy showed IgA nephropathy. Read More

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http://dx.doi.org/10.4103/ijmm.IJMM_19_482DOI Listing

Comparative proteomic analysis of renal proteins from IgA nephropathy model mice and control mice.

Clin Exp Nephrol 2020 May 20. Epub 2020 May 20.

Department of Life Science, Graduate School of Engineering Science, Akita University, 1-1 Tegatagakuen-machi, Akita, Akita, 010-8502, Japan.

Background: High-IgA ddY (HIGA) mice, an animal model of human IgA nephropathy (IgAN), spontaneously develop nephropathy with glomerular IgA deposition and markedly elevated serum IgA levels from 25 weeks of age.

Methods: We performed a comparative proteomic analysis of the renal proteins collected from HIGA mice and control C57BL/6 mice at 5 or 38 weeks of age (the H5, H38, C5, and C38 groups) (n = 4 in each group). Proteins were extracted from the left whole kidney of each mouse and analyzed using nano-liquid chromatography-tandem mass spectrometry. Read More

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http://dx.doi.org/10.1007/s10157-020-01898-5DOI Listing

Circulating inflammation-related factors are correlated with systemic redox status in IgA nephropathy; a case-control study.

Free Radic Biol Med 2020 May 16;155:10-18. Epub 2020 May 16.

Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Background: IgA nephropathy (IGAN) is characterized by oxidative stress and inflammation. In the present study, we explored the relationship of redox status vs. that of circulating inflammation-related factors with other biomarkers in patients with IGAN. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.005DOI Listing

Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: a case report.

BMC Nephrol 2020 May 18;21(1):184. Epub 2020 May 18.

Department of Nephrology, SUNY Upstate Medical University, Syracuse, NY, USA.

Background: Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is characterized by occluding monoclonal pseudothrombi within renal glomerular capillaries and/or interstitial arterioles. Ultrastructurally, these pseudothrombi are unique for having a crystalline substructure. We describe a case of an adult patient with monoclonal B-cell lymphocytosis (MBL) and acute renal failure whose kidney biopsy revealed a rare diagnosis of CAN. Read More

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http://dx.doi.org/10.1186/s12882-020-01818-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236346PMC

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236312PMC

Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets.

Kidney Int 2020 Feb 19. Epub 2020 Feb 19.

Institute of Medical Science, University of Toronto, Toronto, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Division of Nephrology, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada.

Tubulointerstitial injury is an important determinant of chronic kidney disease progression, yet treatment is limited. Accordingly, we derived a chronic kidney disease progression signature based on aging and disease in Col4a3 mice, a model associated with proteinuria and progressive loss of kidney function. Computational drug repurposing with the Connectivity Map identified vorinostat, a lysine deacetylase inhibitor, as a candidate treatment to reverse progression signature gene expression. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.029DOI Listing
February 2020

The precise long-term outcomes of adult IgA nephropathy by mail questionnaires: Better renal survival compared to earlier cohort studies.

PLoS One 2020 15;15(5):e0233186. Epub 2020 May 15.

Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

The estimated 20-year renal survival rate of immunoglobulin A (IgA) nephropathy is approx. 60%, but it is difficult to determine the 'big picture' for IgA nephropathy because a biopsy is essential for its diagnosis. Here we attempted to determine the longer and more precise renal prognosis of IgA nephropathy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233186PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228083PMC

IgA nephropathy associated with thalassemia: a case report.

BMC Nephrol 2020 May 14;21(1):182. Epub 2020 May 14.

The Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P. R. China.

Background: Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Read More

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http://dx.doi.org/10.1186/s12882-020-01844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227039PMC

Hematopoietic stem cell donor with IgA nephropathy: Challenges and management algorithm.

Transfus Apher Sci 2020 May 8:102781. Epub 2020 May 8.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Donor safety is of prime importance in allogeneic hematopoietic cell transplantation. The Worldwide Network for Blood and Marrow Transplantation (WBMT) standing committee on donor issues has issued a consensus statement regarding suitability criteria for related adult donors. This committee recommends that donors with a history of immune-mediated glomerulonephritis and abnormal urine tests should preferably undergo bone marrow harvest, to avoid the theoretical risk of granulocyte colony-stimulating factor (G-CSF) induced immune flare-up. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102781DOI Listing

Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.

Pediatr Res 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.

Methods: Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1038/s41390-020-0951-1DOI Listing

Histologic Case Definition of an Atypical Glomerular Immune-Complex Deposition Following Kidney Transplantation.

Kidney Int Rep 2020 May 5;5(5):632-642. Epub 2020 Feb 5.

Department of Medicine, Division of Nephrology, Stanford University Medical Center, Stanford, California, USA.

Introduction: Immune-complex deposition in the transplanted kidney can present as well-phenotyped recurrent or de novo glomerular disease. However, a subset, herein termed immune-complex glomerulopathy not otherwise specified (ICG-NOS), defies classification. We quantified, categorized, and characterized cases of transplant ICG-NOS occurring at a single US academic medical center. Read More

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http://dx.doi.org/10.1016/j.ekir.2020.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210607PMC

IgA nephropathy: Short term effects of prednisone treatment on proteinuria, renal function and relation with Oxford classification.

Nefrologia 2020 May 11. Epub 2020 May 11.

Unidad de Gestión Clínica de Nefrología, Hospital Universitario de Jaén, Jaén, España.

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http://dx.doi.org/10.1016/j.nefro.2020.02.001DOI Listing

Use of Glycated Hemoglobin (A1c) as a Biomarker for Vascular Risk in Type 2 Diabetes: Its Relationship with Matrix Metalloproteinases-2, -9 and the Metabolism of Collagen IV and Elastin.

Medicina (Kaunas) 2020 May 11;56(5). Epub 2020 May 11.

Department of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.

: HbA1c measurements may be useful not only in optimizing glycemic control but also as a tool for managing overall vascular risk in patients with diabetes. In the present study, we investigate the clinical significance of HbA1c as a biomarker for hyperglycemia-induced vascular damages in type 2 diabetes (T2D) based on the levels of matrix metalloproteinases-2, -9 (MMP-2, MMP-9), anti-collagen IV (ACIV), and anti-elastin (AE) antibodies (Abs) IgM, IgG, and IgA, and CIV-derived peptides (CIV-DP) reflecting collagen and elastin turnover in the vascular wall. The aim is to show the relationship of hyperglycemia with changes in the levels of vascular markers and the dynamics of this relationship at different degrees of glycemic control reported by HbA1c levels. Read More

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http://dx.doi.org/10.3390/medicina56050231DOI Listing

Activation of Complement System in Henoch-Schönlein Purpura Nephritis.

Fetal Pediatr Pathol 2020 May 13:1-8. Epub 2020 May 13.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

We studied the association between Henoch-Schönlein purpura nephritis (HSPN) and complement system activation. We retrospectively reviewed the pathologic findings and medical records of 35 children and 12 adults with HSPN and compared the differences according to C4d positivity in three groups consisting of total 47 patients, 35 pediatric and 12 adult patients, respectively. C4d staining of renal biopsy was additionally performed at the time of diagnosis or retrospectively using archival biopsy material. Read More

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http://dx.doi.org/10.1080/15513815.2020.1761914DOI Listing
May 2020
0.398 Impact Factor

Successful treatment of a patient with posttransplant IgA nephropathy with targeted release formulation of budesonide.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):521-523

Department of Nephropathology, Manipal Hospitals, Bengaluru, Karnataka, India.

Recurrence of glomerulonephritis is the third-leading cause of allograft loss. Graft loss due to IgA nephropathy occurs in 10% at 10-year follow-up. The NEFIGAN trial demonstrated that Target Release Formulation (TRF) of budesonide is a specific treatment for IgA nephropathy targeting intestinal mucosal immunity upstream of disease manifestation with favorable safety profile. Read More

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http://dx.doi.org/10.4103/1319-2442.284029DOI Listing

Comparison of clinicopathological features and prognosis between IgA nephropathy and purpura nephritis in adults with diffuse endocapillary proliferation: a single-center cohort study.

Ann Palliat Med 2020 Apr 26. Epub 2020 Apr 26.

Department of Nephrology (Key Laboratory of Management of Kidney Disease in Zhejiang Province), Guangxing Hospital Affiliated to Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou 310007, China.

Background: Clinical manifestations and histological lesions of IgA nephropathy and Henoch-Schönlein purpura nephritis (HSPN) are different, but related, and are also correlated with the renal outcomes. This study aimed to compare the features of immunoglobulin A nephropathy (IgAN) and HSPN in adult patients with diffuse endocapillary proliferation (DEP) lesions aiming to clarify the differences and relationships in the clinicopathological findings and outcome.

Methods: Twelve patients with DEP-IgAN and 10 patients with DEP-HSPN were enrolled. Read More

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http://dx.doi.org/10.21037/apm.2020.04.04DOI Listing

The TLR4-MyD88-NF-κB pathway is involved in sIgA-mediated IgA nephropathy.

J Nephrol 2020 May 9. Epub 2020 May 9.

Department of Renal Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.

Previous studies have shown that secretory IgA (sIgA) was critically involved in IgA nephropathy (IgAN) immune responses. Toll-like receptors (TLRs), especially TLR4 which participates in mucosal immunity, may be involved in the pathogenesis of IgAN. The purpose of this study was to investigate whether sIgA and TLR4 interact to mediate kidney damage in IgAN patients. Read More

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http://dx.doi.org/10.1007/s40620-020-00722-3DOI Listing

IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis.

Am J Med Sci 2020 Apr 17. Epub 2020 Apr 17.

Department of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.

Immunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. Karyomegalic interstitial nephritis (KIN) is a rare interstitial nephritis with potential hereditary factors. IgA nephropathy concomitant with KIN has not yet been reported. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.04.010DOI Listing

Henoch-Schönlein Purpura in Children: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children.

Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Read More

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http://dx.doi.org/10.2174/1573396316666200508104708DOI Listing

Time series changes in pseudo-R2 values regarding maximum glomerular diameter and the Oxford MEST-C score in patients with IgA nephropathy: A long-term follow-up study.

PLoS One 2020 7;15(5):e0232885. Epub 2020 May 7.

Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

There is no effectual pathological factor to predict the long-term renal prognosis of IgA nephropathy. Glomerular hypertrophy plays a crucial role in kidney disease outcomes in both experimental models and humans. This study aimed to 1) confirm the long-term prognostic significance of a maximal glomerular diameter (Max GD) ≥ 242. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232885PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205238PMC

The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes.

Case Rep Nephrol 2020 20;2020:9480860. Epub 2020 Apr 20.

Department of Immunology and Rheumatology, University Hospital Centre Zagreb, Kispaticeva 12, Zagreb 10 000, Croatia.

IgA nephropathy (IgAN) is a rather uncommon complication of TNF-alpha inhibition with a range of findings such as asymptomatic microscopic/macroscopic hematuria or different degrees of proteinuria and could progress to end-stage renal disease. We are reporting three patients with longstanding rheumatoid arthritis (RA), which developed IgAN while receiving TNF-alpha inhibitors. All off our three patients had RA, which lasted 2-4 years, and none of them had a prior history of chronic kidney disease. Read More

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http://dx.doi.org/10.1155/2020/9480860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191367PMC

Identification of key genes, pathways and potential therapeutic agents for IgA nephropathy using an integrated bioinformatics analysis.

J Renin Angiotensin Aldosterone Syst 2020 Apr-Jun;21(2):1470320320919635

Department of Nephropathy, The First Hospital of Jilin University, China.

Purpose: This study aims to identify immunoglobulin-A-nephropathy-related genes based on microarray data and to investigate novel potential gene targets for immunoglobulin-A-nephropathy treatment.

Methods: Immunoglobulin-A-nephropathy chip data was obtained from the Gene Expression Omnibus database, which included 10 immunoglobulin-A-nephropathy and 22 normal samples. We used the limma package of R software to screen differentially expressed genes in immunoglobulin-A-nephropathy and normal glomerular compartment tissues. Read More

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http://dx.doi.org/10.1177/1470320320919635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227159PMC

The Spectrum of Glomerular Diseases in Mashhad According to Kidney Biopsy Records.

Iran J Kidney Dis 2020 May;14(3):184-190

Kidney Transplantation Complications Research center,Mashhad University of Medical Sciences,Mashhad,Ira.

Introduction: Knowing the national statistics of glomerular diseases will help in the management and minimizing their burden in the community. The aim of this study was to assess the overall distribution of subtypes of glomerulonephritis (GN) and the prevalence of renal diseases in a subgroup of diabetic and hypertensive patients.

Methods: This cross-sectional study was conducted on 860 patients with different subtypes of GN diagnosed by percutaneous renal biopsy and histological examination. Read More

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Plasma chemokine CXC motif-ligand 16 as a predictor of renal prognosis in immunoglobulin A nephropathy.

Ann Transl Med 2020 Mar;8(6):381

Department of Nephrology, Division of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: There are few non-invasive biomarkers that have been identified to improve the risk stratification of patients with IgA nephropathy (IgAN). CXCL16 has been shown to play a key role as a chemoattractant, adhesion, and fibrosis factor in inflammatory disease. This study evaluated the potential for CXCL16 plasma as a potential biomarker in patients with IgAN. Read More

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http://dx.doi.org/10.21037/atm.2020.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186753PMC

JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA Nephropathy.

Clin J Am Soc Nephrol 2020 Apr 30. Epub 2020 Apr 30.

Department of Medicine, Stanford University Medical Center, Stanford, California

Background And Objectives: IgA nephropathy is the most common primary glomerular disease in the world. Marked by mesangial inflammation and proliferation, it generally leads to progressive kidney fibrosis. As the Janus kinase signal transducer and activator of transcription pathway has been implicated as an important mediator of diabetic kidney disease and FSGS, detailed investigation of this pathway in IgA nephropathy was undertaken to establish the basis for targeting this pathway across glomerular diseases. Read More

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http://dx.doi.org/10.2215/CJN.11010919DOI Listing

A case of proliferative glomerulonephritis with immunoglobulin A1-lambda deposits successfully treated by chemotherapy.

CEN Case Rep 2020 Apr 30. Epub 2020 Apr 30.

Division of Nephrology, Department of Internal Medicine, Toyonaka Municipal Hospital, 4-14-1, Shibahara-cho, Toyonaka, Osaka, 560-8565, Japan.

A 74-year-old man presented with nephrotic syndrome and kidney insufficiency. Laboratory tests revealed monoclonal gammopathy of immunoglobulin A-lambda. Renal biopsy revealed diffuse mesangial proliferation and double-contoured basement membranes. Read More

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http://dx.doi.org/10.1007/s13730-020-00480-yDOI Listing

IgA vasculitis and anti-GBM disease: two ends of a spectrum of immune complex vasculitis.

Authors:
Alan D Salama

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii118-iii122

UCL Department of Renal Medicine, Royal Free Hospital, London, UK.

Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes. This report compares our current approach to these uncommon entities in adults. Both diseases demonstrate degrees of small vessel necrosis and glomerular crescent formation. Read More

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http://dx.doi.org/10.1093/rheumatology/kez540DOI Listing

Genetic variants of the MIR31HG gene are related to a risk of IgA nephropathy.

Int Immunopharmacol 2020 Apr 25;84:106533. Epub 2020 Apr 25.

Department of Nephropathy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Electronic address:

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Previous studies reveal that genetic factors play a crucial role in IgAN progression. This study was conducted to investigate the association between MIR31HG variants and IgAN risk. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106533DOI Listing
April 2020
2.472 Impact Factor

Tocilizumab-induced immunocomplex glomerulonephritis: a report of two cases.

CEN Case Rep 2020 Apr 27. Epub 2020 Apr 27.

Department of Nephrology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

We report here two cases of membranoproliferative glomerulonephritis that developed during treatment of rheumatoid arthritis with tocilizumab. In both cases, the initial findings were proteinuria and haematuria, followed by development of bilateral lower leg oedema. One of the patients was weakly positive for anti-nuclear antibody; both had hypocomplementaemia. Read More

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http://dx.doi.org/10.1007/s13730-020-00478-6DOI Listing

A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy.

PLoS One 2020 23;15(4):e0232194. Epub 2020 Apr 23.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Recent studies noted that Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) share the feature of galactose-deficient IgA1 (Gd-IgA1)-oriented pathogenesis, although there are distinct clinical differences. We aimed to clarify the clinicopathologic differences between these 2 diseases.

Methods: We cross-sectionally analyzed adult patients with HSPN (n = 24) or IgAN (n = 56) who underwent renal biopsy (RB) between 2008 and 2018 at Showa University Hospital. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179927PMC

Case 13-2020: A 29-Year-Old Man with High Blood Pressure, Renal Insufficiency, and Hematuria.

N Engl J Med 2020 Apr;382(17):1639-1647

From the Departments of Medicine (A.L.L., S.K.), Radiology (A.M.), and Pathology (K.J.T.), Massachusetts General Hospital, and the Departments of Medicine (A.L.L., S.K.), Radiology (A.M.), and Pathology (K.J.T.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1916254DOI Listing

HLA-B27 Negativity Is Associated With Renal Function Decline in Patients With Ankylosing Spondylitis and Secondary IgA Nephropathy.

Front Med (Lausanne) 2020 7;7:89. Epub 2020 Apr 7.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

This study aimed to determine the impact of HLA-B27 on clinical phenotype and renal function during follow-up periods in patients with ankylosing spondylitis (AS) and secondary IgA nephropathy (IgAN). This single-center retrospective study included 71 AS patients with secondary IgAN. Renal function decline was defined as a mean eGFR decline of more than 5 mL/min/1. Read More

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http://dx.doi.org/10.3389/fmed.2020.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154124PMC

Hansen's disease with lepra reaction presenting with IgA dominant infection related glomerulonephritis.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):289-291

Department of Nephrology, Institute of Nephrology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.

Various renal abnormalities in leprosy have been described largely in literature but the occurrence of IgA dominant infection related glomerulonephritis in leprosy with type 2 lepra reaction has not been reported so far. We present here a 60-year-old man with a history of leprosy in the past admitted with type 2 lepra reaction, rapidly progressive glomerulonephritis with severe renal failure requiring dialysis and diagnosed to have IgA dominant infection related glomerulonephritis. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_654_17DOI Listing
April 2020
0.642 Impact Factor

A unique thymus-derived regulatory T cell subset associated with systemic lupus erythematosus.

Arthritis Res Ther 2020 Apr 21;22(1):88. Epub 2020 Apr 21.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Foxp3 is a marker for regulatory T cells (Treg cells), but recent studies have shown the plasticity and heterogeneity of CD4Foxp3 T cells. This study aimed to examine the phenotype and function of circulating CD4Foxp3 T cells in patients with systemic lupus erythematosus (SLE).

Methods: We enrolled 47 patients with SLE, 31 with organ-specific autoimmune diseases (15 with multiple sclerosis and 16 with primary immune thrombocytopenia), and 19 healthy subjects. Read More

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http://dx.doi.org/10.1186/s13075-020-02183-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171795PMC