8,732 results match your criteria Idiopathic Thrombocytopenic Purpura


Juvenile polyautoimmunity in a rheumatology setting.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.. Electronic address:

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.006DOI Listing
February 2019

Primary Immune Thrombocytopenia (ITP) Treated with Romiplostim in Routine Clinical Practice: Retrospective Study from the United Kingdom ITP Registry.

Eur J Haematol 2019 Feb 13. Epub 2019 Feb 13.

Barts and The London School of Medicine and Dentistry, London, United Kingdom.

Background: Romiplostim is a thrombopoietin-mimetic peptibody for adult refractory chronic immune thrombocytopenia (ITP). We aimed to describe ITP patients receiving romiplostim, platelet counts, and romiplostim usage in UK clinical practice.

Methods: This was a retrospective cohort study of patients in the UKITP Registry who received romiplostim between October 2009 and January 2015, including data up to 6 months before romiplostim initiation through follow-up. Read More

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http://dx.doi.org/10.1111/ejh.13221DOI Listing
February 2019
1 Read

A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.

Case Rep Obstet Gynecol 2019 14;2019:2093612. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Toyooka Public Hospital, 1094, Tobera, Toyooka City, Hyogo 6680065, Japan.

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). Read More

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http://dx.doi.org/10.1155/2019/2093612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348819PMC
January 2019
1 Read

[Successful management of primary immune thrombocytopenia with romiplostim during open heart surgery in a hemodialysis patient].

Rinsho Ketsueki 2019 ;60(1):28-32

Department of Hematology, Faculty of Medicine, University of Tsukuba.

A 66-year-old male undergoing maintenance hemodialysis presented with mild thrombocytopenia. He also had aortic valve stenosis and required aortic valve replacement. In addition, he required anticoagulation therapy with warfarin because of chronic subclavian artery occlusion. Read More

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http://dx.doi.org/10.11406/rinketsu.60.28DOI Listing
January 2019
2 Reads

Long-lasting response to afatinib that persisted after treatment discontinuation in a case of -mutated lung adenocarcinoma.

BMJ Case Rep 2019 Jan 31;12(1). Epub 2019 Jan 31.

Division of Respirology, Department of Internal Medicine, The Jikei University Hospital, Tokyo, Japan.

It is unknown whether tyrosine kinase inhibitors targeting epidermal growth factor receptor (EGFR) can be discontinued in patients in whom -mutated lung cancer has well stabilised. We present a case of a 73-year-old Japanese woman with no history of smoking. Right pulmonary lower lobectomy, lymph node dissection and segmental resection of the right middle lobe were performed. Read More

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http://dx.doi.org/10.1136/bcr-2018-227383DOI Listing
January 2019
1 Read

Scabies presenting as cutaneous nodules or malar erythema: reports of patients with scabies surrepticius masquerading as prurigo nodularis or systemic lupus erythematosus.

Dermatol Online J 2018 Sep 15;24(9). Epub 2018 Sep 15.

School of Medicine, University of California San Diego, La Jolla, California.

Scabies surrepticius is a unifying term that represents non-classical presentations of scabies mite infestation. A patient with scabies surrepticius is described: a man with scabies masquerading as prurigo nodularis. The 91-year-old man had metastatic prostate cancer and presented with diffuse pruritic nodules. Read More

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September 2018
1 Read

Malignant benign hematology.

Res Pract Thromb Haemost 2019 Jan 12;3(1):15-17. Epub 2018 Dec 12.

Departments of Medicine and Laboratory Medicine and Pathobiology St. Michael's Hospital Li Ka Shing Knowledge Institute University of Toronto Toronto Ontario Canada.

When faced with a life-threatening non-cancerous blood disorder, the term "benign" is a misnomer. Devastating diseases like catastrophic antiphospholipid antibody syndrome, acquired hemophilia, and severe immune thrombocytopenia present a challenge to the hematologist. They are often difficult to treat and lack appropriately powered, unbiased evidence to support management. Read More

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http://dx.doi.org/10.1002/rth2.12170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332750PMC
January 2019
4 Reads

Rescue therapy for acute idiopathic thrombocytopenic purpura unresponsive to conventional treatment.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Hematology-Oncology, Louisville School of Medicine, Louisville, Kentucky, USA.

A 61-year-old woman with chronic lymphocytic leukaemia, with Richter's transformation to a diffuse, large, B-cell lymphoma, treated with six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone and in complete remission, presented to the hospital after her platelets were found to be 2×10³/µL in outpatient laboratory studies. She initially underwent a platelet transfusion without improvement. This was followed by 4 days of high-dose dexamethasone and intravenous immunoglobulin, which again yielded no meaningful effect. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22771
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http://dx.doi.org/10.1136/bcr-2018-227717DOI Listing
January 2019
7 Reads

Autoimmune Hepatitis with Concomitant Idiopathic Thrombocytopenic Purpura Diagnosed by Transjugular Liver Biopsy.

Case Reports Hepatol 2018 9;2018:5305691. Epub 2018 Dec 9.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. Read More

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https://www.hindawi.com/journals/crihep/2018/5305691/
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http://dx.doi.org/10.1155/2018/5305691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304620PMC
December 2018
5 Reads

[Refractory primary immune thrombocytopenia in pregnancy requiring splenectomy and repeated intravenous immunoglobulin therapy].

Rinsho Ketsueki 2018 ;59(12):2574-2577

Third Department of Internal Medicine, Yamaguchi University School of Medicine.

A 30-year-old primigravid woman without a history of thrombocytopenia was referred to our hospital because of severe thrombocytopenia (<1,000 thrombocytes/µl) at 16 weeks of gestation and diagnosed with idiopathic thrombocytopenic purpura (ITP). There was no improvement in the platelet count after treatment with 0.5-1. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2574/
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http://dx.doi.org/10.11406/rinketsu.59.2574DOI Listing
January 2018
7 Reads

Mean platelet component and mean platelet volume as useful screening markers for myelodysplastic syndrome.

Health Sci Rep 2018 May 2;1(5):e50. Epub 2018 May 2.

Department of Central Clinical Laboratory Osaka Medical College Hospital Takatsuki Osaka Japan.

Background: Hematologic disorders, including myelodysplastic syndrome (MDS), are difficult to identify in routine hematologic examinations using automated hematology analyzers. However, the practical uses of mean platelet component and mean platelet volume (MPV) measured by these analyzers as screening markers for MDS, remain unclear.

Methods: Mean platelet component and MPV values were measured in the peripheral blood of patients with MDS, aplastic anemia, idiopathic thrombocytopenic purpura, myeloproliferative neoplasms, and in healthy controls using an automated hematologic analyzer. Read More

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http://dx.doi.org/10.1002/hsr2.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266360PMC
May 2018
3 Reads

[Esplenectomía laparoscópica, una opción eficaz en un hospital de segundo nivel].

Cir Cir 2019 ;87(1):23-27

Servicio de Cirugía General, Hospital General de Zona #32 Dr. Mario Madrazo Navarro, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction: Laparoscopic splenectomy was reserved for selected cases, however and because of the improvement in surgical technique and laparoscopic instruments, nowadays, there are few contraindications.

Method: Retrospective and observational study of patients surgically treated of laparoscopic splenectomy secondary to hematologic diseases in a period span of 6 years. We analyzed demographic, preoperative, transoperative and postoperative variables. Read More

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http://dx.doi.org/10.24875/CIRU.18000383DOI Listing
January 2019
2 Reads

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature.

Maxillofac Plast Reconstr Surg 2018 Dec 10;40(1):39. Epub 2018 Dec 10.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940 Republic of Korea.

Background: Patients with chronic ITP (idiopathic thrombocytopenia) frequently do not require comprehensive medication for daily life. Usually, it had been regarded that postoperative bleeding after a simple or surgical extraction is easily controlled by simple local measures even in patients with ITP. This lack of regular medication usage can sometimes lead practitioners or patients to underestimate the potential life-threatening risk of ITP. Read More

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http://dx.doi.org/10.1186/s40902-018-0178-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286906PMC
December 2018
2 Reads

Therapeutic Plasma Exchange in Pediatric Renal Transplantation Experience of One Decade and 389 Sessions.

Transplant Proc 2018 Dec 10;50(10):3483-3486. Epub 2018 Jul 10.

The Children's Memorial Health Institute, Warsaw, Poland. Electronic address:

Objective: There are no specific recommendations for therapeutic plasma exchange (TPE) in children after renal transplantation. The purpose of this study was to report the experience with TPE in a pediatric transplant setting.

Materials And Methods: 59 patients (mean age 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183094
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http://dx.doi.org/10.1016/j.transproceed.2018.07.015DOI Listing
December 2018
8 Reads

Early sofosbuvir-ledipasvir treatment for acute HCV infection induced severe immune thrombocytopenia - a case report.

BMC Infect Dis 2018 Dec 19;18(1):682. Epub 2018 Dec 19.

Service des maladies infectieuses et tropicales, Hospices Civils de Lyon, Hôpital de la Croix Rousse, 69004, Lyon, France.

Background: Hepatitis C virus (HCV) infection is a recognised cause of secondary immune thrombocytopenia (ITP). While its incidence has been largely described during chronic HCV infection, only one case of ITP secondary to acute HCV infection has been reported at this time.

Case Presentation: We report herein the case of severe ITP secondary to an acute HCV genotype 1a reinfection in a human immunodeficiency virus (HIV)-negative man having sex with men who had been cured several years before of a previous acute genotype 4d HCV infection. Read More

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http://dx.doi.org/10.1186/s12879-018-3597-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300032PMC
December 2018
5 Reads

Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy.

CEN Case Rep 2018 Dec 18. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.

Measurement of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio may be clinically useful to discriminate systemic lupus erythematosus (SLE) from preeclampsia. Here, we present a pregnant woman with new-onset SLE with hypertension, with the measurement of the sFlt-1/PlGF ratio during pregnancy. A 31-year-old Japanese nulliparous woman, who had been diagnosed with idiopathic thrombocytopenic purpura at 10 years, had a systolic blood pressure of 120 mmHg and was negative for proteinuria at 12 weeks. Read More

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http://dx.doi.org/10.1007/s13730-018-0373-7DOI Listing
December 2018
3 Reads

Prediction of Technical Difficulties in Laparoscopic Splenectomy and Analysis of Risk Factors for Postoperative Complications in 468 Cases.

J Clin Med 2018 Dec 14;7(12). Epub 2018 Dec 14.

2nd Department of General Surgery, Jagiellonian University Medical College, 31-501 Kraków, Poland.

Prediction of intraoperative difficulties may be helpful in planning surgery; however, few studies explored this issue in laparoscopic splenectomy (LS). We performed retrospective analysis of consecutive 468 patients undergoing LS from 1998 to 2017 (295 women; median age 47 years). The patients were divided into difficult LS and control groups. Read More

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http://dx.doi.org/10.3390/jcm7120547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306709PMC
December 2018
1 Read

MiR-212-5p regulates the proliferation and apoptosis of AML cells through targeting FZD5.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8415-8422

Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: To explore the effects of microRNA-212-5p (miR-212-5p) on biological functions of acute myeloid leukemia (AML) and to find the potential molecular mechanism.

Patients And Methods: We measured the expression level of miR-212-5p in 35 AML patients and 20 patients with idiopathic thrombocytopenic purpura (ITP) as control cases. Besides, the miR-212-5p expression at cellular level was checked as well. Read More

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http://dx.doi.org/10.26355/eurrev_201812_16540DOI Listing
December 2018
1 Read

A Case of Multiple Cerebral Infarction Preceding Acute Exacerbation of Idiopathic Thrombocytopenic Purpura.

J Stroke Cerebrovasc Dis 2019 Mar 13;28(3):789-791. Epub 2018 Dec 13.

Department of Neurology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan.

Background: Although it was suggested that idiopathic thromobocytopenic purpura (ITP) can be a paradoxical cause of cerebral infarction, previous reports indicate that cerebral infarction associated with ITP occurs when thrombocytopenia is already evident at the onset of cerebral infarction.

Case Report: We report a case of multiple cerebral infarction that preceded acute exacerbation of ITP. An 80-year-old woman with a history of ITP presented with tetraplegia, and brain magnetic resonance imaging revealed multiple infarction in bilateral cerebral and cerebellar hemispheres. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.026DOI Listing

Immune-mediated hemolytic anemia and thrombocytopenia in clonal B-cell disorders: a review.

Clin Adv Hematol Oncol 2018 Oct;16(10):670-676

Mayo Clinic, Rochester, Minnesota.

Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and treatment of these autoimmune disorders, specifically in the setting of B-cell malignancies. AIHA and ITP are classically associated with chronic lymphocytic leukemia (CLL) but have also been reported in plasmacytic and lymphoproliferative disorders. Read More

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October 2018
1 Read

Predictive Factors for Success of Laparoscopic Splenectomy for ITP.

JSLS 2018 Oct-Dec;22(4)

Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, Hungary.

Background And Objectives: Therapy-resistant immune thrombocytopenia (ITP) is the most frequent indication of laparoscopic splenectomy (LS). It ensures the best results for this disease compared with possible second-line pharmacologic therapies. Therefore, learning about the safety of the surgical method and its long-term efficacy is important, as is selecting patients who respond to surgical treatment. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248273PMC
January 2019
1 Read

Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine (CC, KR, YG, ZF, MM); Department of Hematology (AP-P); Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL (SJC).

: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000485DOI Listing
November 2018
3 Reads

Evidence-based management of immune thrombocytopenia: ASH guideline update.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):568-575

Imperial College Health Care NHS Trust, Hammersmith Hospital, London, UK.

In 1996 and 2011, the American Society of Hematology (ASH) supported efforts to create guidelines for the diagnosis and management of patients with immune thrombocytopenia (ITP). These guidelines used different approaches to arrive at recommendations for testing and treatment. Despite differences in methodology, in both cases there was a paucity of randomized trials to inform recommendations. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245979PMC
November 2018
28 Reads

How do we diagnose immune thrombocytopenia in 2018?

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):561-567

Michael G. DeGroote School of Medicine, Department of Medicine and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

In this report, we will review the various clinical and laboratory approaches to diagnosing immune thrombocytopenia (ITP), with a focus on its laboratory diagnosis. We will also summarize the results from a number of laboratories that have applied techniques to detect anti-platelet autoantibodies as diagnostic tests for ITP. Although there is considerable variability in methods among laboratories, there is general agreement that platelet autoantibody testing has a high specificity but low sensitivity. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245958PMC
November 2018
9 Reads

Pediatric ITP: is it different from adult ITP?

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):405-411

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, TX.

Immune thrombocytopenia (ITP) has historically been thought to occur in 2 distinct forms: childhood ITP and adult ITP. This division is based largely on the presumption that childhood ITP is often benign and self-limited, whereas ITP in adults tends to be more chronic and difficult to treat. Although data exist to justify a different approach to the diagnosis and treatment in young children and the elderly, ITP in older children, adolescents, and younger adults is likely to share more similar pathology. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246008PMC
November 2018
7 Reads

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2019 Jan 30;37(2):366-371. Epub 2018 Nov 30.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.045DOI Listing
January 2019
1 Read

[Expression and Clinical Significance of Peripheral Blood T cell JAK2/STAT3 mRNA in Chronic Idiopathic Thrombocytopenic Purpura].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1746-1751

Department of Microbiological immunoplay,Zhanjiang 524023,Guangdong Province, China.

Objective: To detect the expression of JAK2/STAT3 mRNA in peripheral blood T cells from the patients with chronic idiopathic thrombocytopenic purpura(CITP), and to explore the relationship between JAK2/STAT3 mRNA and CITP.

Methods: CITP group and healthy control group were set in this study, The JAK2/STAT3 mRNA expression level in peropheral blood T cells of 2 groups was detected with the RT-PCR and agarose gel electrophoresis.

Results: JAK2 mRNA expression level in CITP group was significantly higher than that in control group(P<0. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.06.028DOI Listing
December 2018
1 Read

Importance of Th22 Cell Disequilibrium in Immune Thrombocytopenic Purpura.

Med Sci Monit 2018 Dec 4;24:8767-8772. Epub 2018 Dec 4.

Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).

BACKGROUND The disequilibrium of T helper (Th) cells play an important role in the occurrence and development of immune thrombocytopenic purpura (ITP). Th22 cells, as a newly discovered subset of T lymphocytes, plays an important role in autoimmune disorders and inflammatory diseases. MATERIAL AND METHODS This study explored the role of different lymphocyte subsets in chronic ITP. Read More

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https://www.medscimonit.com/abstract/index/idArt/912528
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http://dx.doi.org/10.12659/MSM.912528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289030PMC
December 2018
12 Reads

Platelet count on preoperative day 1 predicts the long-term responses to laparoscopic splenectomy for Chinese patients with medically refractory idiopathic thrombocytopenic purpura.

BMC Surg 2018 Nov 26;18(1):108. Epub 2018 Nov 26.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Chongqing, 400016, China.

Background: Laparoscopic splenectomy (LS) is regarded as a second-line treatment for medically refractory idiopathic thrombocytopenic purpura (ITP), but the predictive factors for the long-term postoperative responses to ITP are still a matter of debate. We aimed to investigate the factors that can predict the long-term response after LS for Chinese patients with medically refractory ITP.

Methods: From January 2011 to September 2016, 78 Chinese patients with ITP who underwent LS were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12893-018-0446-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260580PMC
November 2018
2 Reads

Flow cytometry and immune thrombocytopenic purpura.

Transfus Apher Sci 2018 Dec 30;57(6):800-803. Epub 2018 Oct 30.

International Consultancy in Blood Components Quality/Safety, Audit/Injection and DDR Strategies, London, UK. Electronic address:

Although Immune thrombocytopenic purpura is a common disorder that family physicians, internists and hematologists face in their everyday practice, its diagnosis rests only on "exclusion" and its therapy is based on algorithms where "trial and error" is the rule. Flow cytometry, if simplified and standardized, could provide a quicker and better diagnostic accuracy. Studies of the lymphocyte subset using flow cytometry and more elaborate immune studies are paving the way for a better understanding of the disease and in identification of prognostic markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14730502183043
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http://dx.doi.org/10.1016/j.transci.2018.10.018DOI Listing
December 2018
16 Reads

MYH9 Associated nephropathy.

Nefrologia 2018 Nov 21. Epub 2018 Nov 21.

Enfermedades Renales Hereditarias, Servicio de Nefrología, Fundació Puigvert, Barcelona, España; Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, España; Universidad Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Barcelona, España. Electronic address:

MYH9 related diseases are caused by mutations in the MYH9 gene and constitute a rare group of genetic entities. Its inheritance follows an autosomal dominant pattern. The MYH9 gene, encodes the nonmuscle myosin heavy chain IIA, expressed in different tissues and especially in podocytes and mesangial cells. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.08.008DOI Listing
November 2018
1 Read

The systematic case-referent method.

Therapie 2018 Oct 26. Epub 2018 Oct 26.

London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.

The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More

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http://dx.doi.org/10.1016/j.therap.2018.09.073DOI Listing
October 2018
15 Reads

Analysis of chemical components in herbal formula Qi Bai Granule by UPLC-ESI-Q-TOF-MS.

Nat Prod Res 2018 Nov 16:1-5. Epub 2018 Nov 16.

a State Key Laboratory of Critical Technology in Innovative Chinese Medicine, TCM Research Center , Tasly Academy , Tianjin , China.

Qi Bai Granule (QBG), a traditional Chinese medicine formula for the treatment of idiopathic thrombocytopenic purpura, is composed of seven herbs. It is necessary to learn its chemical composition for quality control. In this study, a method for rapid separation and structural identification of the constituents in QBG was established by UPLC-ESI-Q-TOF-MS in negative and positive ion mode. Read More

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http://dx.doi.org/10.1080/14786419.2018.1495641DOI Listing
November 2018
12 Reads

A Wide Spectrum of Autoimmune Manifestations and Other Symptoms Suggesting Immune Dysregulation in Patients With Cartilage-Hair Hypoplasia.

Front Immunol 2018 25;9:2468. Epub 2018 Oct 25.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Mutations in , encoding a non-coding RNA molecule, underlie cartilage-hair hypoplasia (CHH), a syndromic immunodeficiency with multiple pathogenetic mechanisms and variable phenotype. Allergy and asthma have been reported in the CHH population and some patients suffer from autoimmune (AI) diseases. We explored AI and allergic manifestations in a large cohort of Finnish patients with CHH and correlated clinical features with laboratory parameters and autoantibodies. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02468
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http://dx.doi.org/10.3389/fimmu.2018.02468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209636PMC
October 2018
13 Reads

Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials.

Gastroenterol Res Pract 2018 9;2018:6090878. Epub 2018 Oct 9.

Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea.

Objective: Several recent reviews of published studies have shown that the eradication of infection in patients with ITP improved thrombocytopenia in about half of the cases. However, most included studies were observational case series. We performed the first meta-analysis of randomized trials to gain a better insight into the effect of eradication in ITP patients. Read More

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https://www.hindawi.com/journals/grp/2018/6090878/
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http://dx.doi.org/10.1155/2018/6090878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198559PMC
October 2018
7 Reads

Prevalence and correlates of thrombosis in adults with immune thrombocytopenia: An NIS study.

Thromb Res 2018 12 24;172:80-85. Epub 2018 Oct 24.

Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America; Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, United States of America.

Background: Immune thrombocytopenia (ITP) is increasingly recognized as a thrombophilic disorder. However, no further investigation of risk factors has been conducted to date. This study evaluated classic and disease-specific correlates of thrombosis among ITP patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183057
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http://dx.doi.org/10.1016/j.thromres.2018.10.017DOI Listing
December 2018
6 Reads

Relevance of antiphospholipid antibody profile in the clinical outcome of ITP: a single-centre study.

Hematology 2019 Dec 25;24(1):134-138. Epub 2018 Oct 25.

a Department of Medicine , Padova University School of Medicine , Padova , Italy.

Objectives: The relevance of detecting antibodies against anticardiolipin, β2-glycoprotein I (β2gpI) or lupus anticoagulant (LA), collectively called antiphospholipid autoantibodies (APA), in subjects with immune thrombocytopenia (ITP) is still a debated issue. In particular, whether APA profile may affect the clinical course of ITP is unknown.

Methods: In this study, we report our experience in a cohort of ITP patients with APA with specific interest to the relevance of different antiphospholipid antibody profiles in clinical outcome and response to treatment. Read More

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http://dx.doi.org/10.1080/10245332.2018.1532649DOI Listing
December 2019
1 Read

Effectiveness of Haemophilus influenzae type b vaccination after splenectomy - impact on selected immunological parameters.

Hum Vaccin Immunother 2018 Oct 23:1-10. Epub 2018 Oct 23.

a Department of Clinical Immunology and Immunotherapy , Medical University of Lublin , Lublin , Poland.

Splenectomy is a surgery indicated in case of splenic rupture after injury, when there are tumors in the spleen, or as a treatment for certain diseases, such as idiopathic thrombocytopenic purpura and spherocytosis. The aims of the study were to assess the immunological response to the Haemophilus influenzae type b (Hib) vaccine and the post-vaccination changes in lymphocyte subsets and cell activation markers in splenectomized patients and healthy volunteers. Blood samples were collected from 25 patients that had undergone splenectomy and from 15 healthy, non-splenectomized volunteers. Read More

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http://dx.doi.org/10.1080/21645515.2018.1537744DOI Listing
October 2018
10 Reads

A comprehensive targeted next-generation sequencing panel for genetic diagnosis of patients with suspected inherited thrombocytopenia.

Res Pract Thromb Haemost 2018 Oct 8;2(4):640-652. Epub 2018 Oct 8.

Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK.

Background: Inherited thrombocytopenias (ITs) are a heterogeneous group of disorders characterized by low platelet counts and often disproportionate bleeding with over 30 genes currently implicated. Previously the UK-GAPP study using whole exome sequencing (WES) identified a pathogenic variant in 19 of 47 (40%) patients of which 71% had variants in genes known to cause IT.

Aims: To employ a targeted next-generation sequencing platform to improve efficiency of diagnostic testing and reduce overall costs. Read More

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http://doi.wiley.com/10.1002/rth2.12151
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http://dx.doi.org/10.1002/rth2.12151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178765PMC
October 2018
15 Reads

Chronic Thromboembolic Pulmonary Hypertension and Antiphospholipid Syndrome with Immune Thrombocytopenia: A Case Report.

Am J Case Rep 2018 Oct 19;19:1245-1248. Epub 2018 Oct 19.

Department of Internal Diseases, Vienna General Hospital, Vienna, Austria.

BACKGROUND Antiphospholipid syndrome is an autoimmune disorder characterized by a hypercoagulable state associated with circulating antiphospholipid antibodies. The presence of antiphospholipid antibodies can result in a variety of clinical symptoms, such as thrombocytopenia, stillbirth, endocardial pathologies, and recurrent pulmonary embolism. CASE REPORT We present the case of a 23-year-old man with antiphospholipid syndrome and chronic thromboembolic pulmonary hypertension who developed severe thrombocytopenia. Read More

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https://www.amjcaserep.com/abstract/index/idArt/909778
Publisher Site
http://dx.doi.org/10.12659/AJCR.909778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202878PMC
October 2018
9 Reads

Clinical presentation in thrombotic thrombocytopenic purpura: Real-world data from two Mexican institutions.

J Clin Apher 2018 Dec 15;33(6):645-653. Epub 2018 Oct 15.

Hematology Service, Department of Internal Medicine, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Background: Thrombotic thrombocytopenic purpura (TTP) is a hematologic disease that can be fatal if not treated early. We aimed to describe the clinical characteristics of Mexican patients with idiopathic TTP.

Study Design And Methods: We conducted a retrospective study, including all adult patients diagnosed with idiopathic TTP from 2011 to 2017 in two Mexican centers. Read More

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http://dx.doi.org/10.1002/jca.21659DOI Listing
December 2018
6 Reads

Association of cytotoxic T-lymphocyte antigen 4 gene with immune thrombocytopenia in Chinese Han children.

Hematology 2019 Dec 14;24(1):123-128. Epub 2018 Oct 14.

e The Gerontology Department , The First Clinical Medical College of Lanzhou university , Lanzhou , People's Republic of China.

Objectives: To investigate the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) with immune thrombocytopenia (ITP).

Methods: A case-control association analysis of 277 Chinese Han children was performed. The tagging variants rs11571315 and rs3087243 in the CTLA4 gene were detected using polymerase chain reaction-restriction fragment length polymorphism method. Read More

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https://www.tandfonline.com/doi/full/10.1080/10245332.2018.1
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http://dx.doi.org/10.1080/10245332.2018.1530179DOI Listing
December 2019
10 Reads

Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report.

Hepatol Commun 2018 Oct 25;2(10):1179-1183. Epub 2018 Sep 25.

Liver Unit and Department of Biomedical Sciences Humanitas University Rozzano Italy.

We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF when HCV-RNA tested negative, suggesting a link between rapid HCV clearance and autoimmune diseases. This case report proposes new immunologic scenarios in patients with hepatitis C virus (HCV) with laboratory or clinical signs of autoimmunity during direct-acting antiviral (DAA) therapy. Read More

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http://dx.doi.org/10.1002/hep4.1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167068PMC
October 2018
3 Reads

Distinguishing autoimmune myelofibrosis from primary myelofibrosis.

Clin Adv Hematol Oncol 2018 Sep;16(9):619-626

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Bone marrow fibrosis (BMF) is a histologic finding in a wide range of diseases, including malignancies, endocrine disorders, autoimmune diseases, and infections. Autoimmune myelofibrosis (AIMF) is an uncommon etiology of BMF; it can be secondary to a defined autoimmune disease, or it can be primary in the absence of a clinically diagnosed autoimmune disease but the presence of serologic evidence of autoantibodies. Distinguishing between primary myelofibrosis (PMF) and non-neoplastic AIMF is of the utmost importance because the prognosis and therapeutic options are different. Read More

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September 2018
6 Reads

The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura.

BMC Hematol 2018 20;18:28. Epub 2018 Sep 20.

2Department of Gastroenterology, Aleppo University Hospital, Aleppo, Syria.

Background: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether eradication will increase platelet counts in adult ITP patients. Read More

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http://dx.doi.org/10.1186/s12878-018-0119-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148778PMC
September 2018
2 Reads

Successful treatment of acquired hemophilia A associated with immune thrombocytopenia and joint hemarthrosis: A case report and literature review.

Authors:
Fang Wei

Medicine (Baltimore) 2018 Sep;97(38):e12044

Introduction: Acquired hemophilia A (AHA) is a rare bleeding disease caused by autoantibodies against factor VIII (FVIII). Spontaneous bleeding symptoms usually affect the skin, musco, muscle, and internal organs, while joint hemarthrosis in AHA is an extremely rare manifestation. AHA may have an autoimmune cause and is often associated with autoimmune disease, but no demonstrable platelet impairment was found in AHA patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000012044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160082PMC
September 2018
2 Reads

Proteasome Inhibition with Bortezomib Induces Apoptosis of Long-Lived Plasma Cells in Steroid-Resistant or Relapsed Immune Thrombocytopaenia.

Thromb Haemost 2018 Oct 20;118(10):1752-1764. Epub 2018 Sep 20.

Department of Haematology, Qilu Hospital, Shandong University, Jinan, China.

Primary immune thrombocytopaenia (ITP) is the most common haemorrhagic disease. Although most patients respond initially to mainstream therapies, such as corticosteroids, immunosuppressants or rituximab, a large proportion of patients fail to respond or relapse. These treatments only affect B lymphocytes or short-lived plasma cells, but not already existing long-lived plasma cells (LLPCs) which persistently secrete antibodies. Read More

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http://dx.doi.org/10.1055/s-0038-1669921DOI Listing
October 2018
7 Reads

Acquired thrombotic thrombocytopenia purpura associated with severe ADAMTS13 deficiency in a 3-year-old boy: a case report and review of the literature.

J Med Case Rep 2018 Sep 17;12(1):276. Epub 2018 Sep 17.

Department of Pathology, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia.

Background: Acquired thrombotic thrombocytopenia purpura is very rarely encountered in children. It is often misdiagnosed initially when the condition is not inherited.

Case Presentation: We describe a 3-year-old Malay boy who presented with simple febrile seizure and had no neurological deficit, however, he was found to have microangiopathic hemolytic anemia, thrombocytopenia, and elevated serum lactate dehydrogenase. Read More

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http://dx.doi.org/10.1186/s13256-018-1806-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142628PMC
September 2018
4 Reads