9,162 results match your criteria Idiopathic Thrombocytopenic Purpura


In reply to the letter to the editor "Tele(oral)medicine: A new approach during the COVID-19 crisis".

Oral Dis 2020 May 31. Epub 2020 May 31.

AssistantProfessor, Oral Medicine Department, Facultad de Odontologia, Universidad Nacional de Córdoba, Córdoba, Argentina.

We would like tocongratulate Villa et al fora recent published letter to the editor(Villa et al; 2020), emphasizing the use of tele(oral)medicine as an effective diagnostic tool(Estai et al, 2018),which could be usefulin the current time of crisis.The COVID-19 pandemic, and the social isolation measures mandatedby health authorities haveled toa reassessing of the professional practicesin our Dental College. Read More

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http://dx.doi.org/10.1111/odi.13454DOI Listing

Idiopathic thrombocytopenic purpura treatment in a relapsed/refractory multiple myeloma patient after chimeric antigen receptor T cell therapy.

Regen Ther 2020 Jun 15;14:271-274. Epub 2020 May 15.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.

The adoptive transfer of CAR-T cells, which are modified T cells expressing chimeric antigen receptors (CARs), to target B cell maturation antigen (BCMA) has demonstrated impressive results in treating relapsed/refractory multiple myeloma. Although BCMA CAR-T therapy induces certain complications in some patients, idiopathic thrombocytopenic purpura (ITP) has not been reported as one of them. To the best of our knowledge, this is the first report of the successful treatment of ITP that arose in a relapsed/refractory multiple myeloma patient following anti-BCMA CAR-T cell infusion. Read More

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http://dx.doi.org/10.1016/j.reth.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232090PMC

[Right Atrial Thrombus which was Difficult to Differentiate from Tumor;Report of a Case].

Kyobu Geka 2020 Mar;73(3):227-229

Department of Cardiovascular Surgery, Nihonkai General Hospital, Sakata, Japan.

We report a case of a 79-year-old woman with a right atrial mass. She had a history of hypertension, idiopathic thrombocytopenic purpura, and chronic atrial fibrillation. Computed tomography and transthoracic echocardiography showed a 31×31 mm mass in the right atrium. Read More

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Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura.

Intern Med 2020 May 8. Epub 2020 May 8.

Department of Hematology, Niigata Prefectural Shibata Hospital, Japan.

A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. Read More

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http://dx.doi.org/10.2169/internalmedicine.4255-19DOI Listing

Research progress in relation of infection with pregnancy-related diseases and adverse pregnancy outcomes.

Authors:
Bai Zhou Fen Wang

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Mar;45(3):338-344

Depatment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013

() is a Gram-negative microaerobic bacterium, which is parasitic on gastric mucosa and is associated with the pathogenesis of chronic gastritis, gastric ulcer, gastric cancer and other gastric diseases. Meanwhile, the infection is related with pregnancy-related diseases, pregnancy outcomes, and the health status of offspring, such as infertility, premature delivery, abortion, infection of newborn and neural tube defects. infection is also related to hyperemesis of pregnancy, preeclampsia, gestational diabetes mellitus, iron deficiency anemia, idiopathic thrombocytopenic purpura. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190032DOI Listing

Response to 'Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura' by Xie and Zhang.

Ann Rheum Dis 2020 May 7. Epub 2020 May 7.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

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http://dx.doi.org/10.1136/annrheumdis-2020-217694DOI Listing

Bone Marrow Langerhans Cell Histiocytosis in Association with Kasabach-Merritt Syndrome: The Difficulty of a Differential Diagnosis.

Case Rep Oncol 2020 Jan-Apr;13(1):408-413. Epub 2020 Apr 14.

Department of Internal Medicine II, Professor Doutor Fernando Fonseca Hospital, Amadora, Portugal.

Langerhans cell histiocytosis is a rare haematological disorder with variable clinical findings and a high mortality rate. On the other hand, Kasabach-Merritt syndrome is of rare onset at adult age, requiring the simultaneous presentation of vascular lesion, thrombocytopenia, and consumptive coagulopathy. We present the first reported case of both diseases in a single patient and highlight the difficulties of diagnostic. Read More

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http://dx.doi.org/10.1159/000506539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184841PMC

Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a need for a more accurate control group?

Ann Rheum Dis 2020 Apr 27. Epub 2020 Apr 27.

Centre National de Référence des Maladies Systémiques et Autoimmunes Rares Est Sud-Ouest (RESO), Department of Rheumatology, Strasbourg, France.

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http://dx.doi.org/10.1136/annrheumdis-2020-217651DOI Listing

Serendipitous Finding of Asymptomatic Babesiosis in a Patient With Symptomatic Thrombocytopenia.

J Hematol 2019 Dec 25;8(4):168-170. Epub 2019 Dec 25.

Division of Hematology/Oncology, Lenox Hill Hospital, New York, NY, USA.

We report a case of isolated immune thrombocytopenic purpura (ITP) as a result of babesiosis infection. The patient initially presented with a history, physical exam and laboratory findings consistent with idiopathic thrombocytopenic purpura. She was treated with standard of care therapy without clinical response. Read More

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http://dx.doi.org/10.14740/jh570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155809PMC
December 2019

Immune Thrombocytopenic Purpura in a Patient with Covid-19.

N Engl J Med 2020 04 15;382(18):e43. Epub 2020 Apr 15.

Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1056/NEJMc2010472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179995PMC

Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms.

J Pediatr Hematol Oncol 2020 Apr 13. Epub 2020 Apr 13.

Departments of Clinical Pathology.

Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous immunologic disorder. Vitamin D has immune-modulatory effects. The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001801DOI Listing

Use of romiplostim in pregnancy for refractory idiopathic thrombocytopenic purpura: Two case reports with maternal and fetal outcomes and literature review.

Obstet Med 2020 Mar 29;13(1):45-50. Epub 2018 May 29.

Lyell McEwin Hospital, Elizabeth Vale, Australia.

Idiopathic thrombocytopenic purpura is a relatively rare complication occurring in pregnancy, with the potential for serious maternal and fetal outcomes. Rarely, the poor response to established first-line therapies results in consideration of second-line therapies, which may have poorly understood risks to the fetus. We report two women with severe idiopathic thrombocytopenic purpura during pregnancy unresponsive to corticosteroids and intravenous immunoglobulin who were treated with romiplostim, a thrombopoietin receptor agonist. Read More

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http://dx.doi.org/10.1177/1753495X18773960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133099PMC

Clinical, immunological and genetic characteristic of patients with clinical phenotype associated to LRBA-deficiency in Colombia.

Colomb Med (Cali) 2019 Sep 30;50(3):176-191. Epub 2019 Sep 30.

Universidad de Antioquia UdeA, Facultad de Medicina, Grupo de Inmunodeficiencias Primarias, Medellin, Colombia.

Background: LPS-responsive beige -like anchor protein (LRBA) deficiency is a primary immunodeficiency disease caused by loss of LRBA protein expression, due to biallelic mutations in gene. LRBA deficiency patients exhibit a clinically heterogeneous syndrome. The main clinical complication of LRBA deficiency is immune dysregulation. Read More

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http://dx.doi.org/10.25100/cm.v50i3.3969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141146PMC
September 2019

Femoral pseudotumor secondary to injury in a patient with idiopathic thrombocytopenic purpura: Case report.

Medicine (Baltimore) 2020 Apr;99(15):e19788

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang Hebei Province, China.

Rationale: Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count of unknown causes and is a poorly understood acquired hemorrhagic disease involving destruction of platelets in the reticuloendothelial system induced by antiplatelet antibodies. Patients with ITP can have traumatic intra-articular, intraosseous or soft tissue hemorrhage which may present as a rare intraosseous pseudotumor on medical imaging.

Patient Concerns: A 30-year old male patient had complaint of pain in the right leg for 1 year. Read More

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http://dx.doi.org/10.1097/MD.0000000000019788DOI Listing
April 2020
5.723 Impact Factor

Pseudothrombocytopenia by ethylenediaminetetraacetic acid can jeopardize patient safety - report.

EJIFCC 2020 Mar 20;31(1):65-69. Epub 2020 Mar 20.

Servicio de Análisis Clinicos, Hospital Álvaro Cunqueiro, Vigo, Spain.

Pseudothrombocytopenia by ethylenediaminetetraacetic acid (EDTA) is an infrequent phenomenon of platelet agglutination due to the presence of antiplatelet autoantibodies. It has no clinical significance, but misdiagnosis may lead to clinical or therapeutic decision-making. In this study we report a case of an 8-year-old boy with no history of platelet disorder presenting a low platelet count and a peripheral blood smear showing clumping of platelets by EDTA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109506PMC

Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a population-based cohort study.

Ann Rheum Dis 2020 Jun 2;79(6):793-799. Epub 2020 Apr 2.

Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China

Background: Idiopathic thrombocytopenic purpura (ITP) may play a role in early-stage systemic lupus erythematosus (SLE). The incidence of SLE in patients with ITP and the potential relationship between them is still unclear. This study was performed to provide epidemiological evidence regarding the relationship between ITP and SLE occurrence. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217013DOI Listing

Recurrent Acute Coronary Syndromes in a Patient with Idiopathic Thrombocytopenic Purpura.

Case Rep Cardiol 2020 12;2020:6738348. Epub 2020 Mar 12.

Department of Cardiology, University General Hospital of Larissa, Larissa, Greece.

A 53-year-old man was admitted to a peripheral hospital with the diagnosis of acute myocardial infarction without ST elevation. Due to the concomitant presence of first-diagnosed thrombocytopenia (platelet count 50.000/L), it was decided to be treated conservatively with clopidogrel. Read More

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http://dx.doi.org/10.1155/2020/6738348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093901PMC

Management of major bleeds in patients with immune thrombocytopenia.

J Thromb Haemost 2020 Mar 26. Epub 2020 Mar 26.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: A standard approach to the recognition and management of major bleeding in immune thrombocytopenia (ITP) is lacking.

Methods: Retrospective cohort study of ITP patients presenting to the emergency department (ED) with severe thrombocytopenia (platelet count <20 × 10 /L) and bleeding in four academic hospitals from 2008 to 2016. We defined a major ITP bleed as a bleed at a critical site or causing hemodynamic instability. Read More

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http://dx.doi.org/10.1111/jth.14809DOI Listing

Post-splenectomy Sepsis: A Review of the Literature.

Cureus 2020 Feb 6;12(2):e6898. Epub 2020 Feb 6.

Pediatrics, Dow University of Health Sciences, Karachi, PAK.

The spleen is an intraperitoneal organ that performs vital hematological and immunological functions. It maintains both innate and adaptive immunity and protects the body from microbial infections. The removal of the spleen as a treatment method was initiated from the early 1500s for traumatic injuries, even before the physiology of spleen was properly understood. Read More

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http://dx.doi.org/10.7759/cureus.6898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059871PMC
February 2020

Immune Thrombocytopenia. Reply.

N Engl J Med 2020 03;382(11):1077-1078

Østfold Hospital, Sarpsborg, Norway.

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http://dx.doi.org/10.1056/NEJMc1913324DOI Listing

Immune Thrombocytopenia.

N Engl J Med 2020 03;382(11):1077

Saol Therapeutics, Roswell, GA

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http://dx.doi.org/10.1056/NEJMc1913324DOI Listing

Severe Immune Thrombocytopenia in a Patient with HIV-HCV Co-infection: Challenges in Management.

J Assoc Physicians India 2020 Mar;68(3):77-79

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Immune thrombocytopenia is a well-known complication of both HIV and Hepatitis C virus infections. Management becomes challenging when a patient with HCV-HIV co-infection presents with severe thrombocytopenia. Adverse drug reactions and drug interactions has to be considered while choosing treatment options for such patients. Read More

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[Interpretation of the updated international consensus report on the investigation and management of adult primary immune thrombocytopenia (version 2019)].

Authors:
X G Liu M Hou

Zhonghua Xue Ye Xue Za Zhi 2020 Feb;41(2):89-92

Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.02.001DOI Listing
February 2020

Leptospirosis in an asplenic patient -case report.

BMC Infect Dis 2020 Feb 28;20(1):186. Epub 2020 Feb 28.

Departamento de Biología Molecular e Histocompatibilidad, Dirección de investigación, Hospital General "Dr. Manuel Gea González", Mexico City, Mexico.

Background: The presentation of clinical leptospirosis has been historically associated with animal workers, slaughterhouse workers and medical veterinarians. This association has shifted to be related to flooding events and outdoor activities; few cases are related to high-risk factors found in immunosuppressed patients. Scarcely a handful of cases have serological evidence of immune response against Leptospira serovar Bratislava representing serogroup Australis, a serovar associated with poor reproductive performance in swine and horses, and recently with cats. Read More

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http://dx.doi.org/10.1186/s12879-020-4869-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048021PMC
February 2020

Immune thrombocytopenia in a case of trisomy 18.

Pediatr Int 2020 Feb 17;62(2):240-242. Epub 2020 Feb 17.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Hokkaido, Japan.

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http://dx.doi.org/10.1111/ped.14116DOI Listing
February 2020

Immature platelet fraction: A useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery.

Medicine (Baltimore) 2020 Feb;99(7):e19096

Departments of Laboratory Medicine, Hallym University Sacred Heart Hospital, Departments of Laboratory Medicine, Hallym University College of Medicine, Anyang, Republic of Korea.

Introduction: The assessment of bone marrow thrombopoietic activity in patients with thrombocytopenia is necessary to achieve an accurate diagnosis and administer effective treatment. We evaluated the discriminatory power of the immature platelet fraction (IPF) in differentiating hyperdestructive/consumptive thrombocytopenia from hypoproductive thrombocytopenia and its potential use as a predictive marker for platelet recovery.

Methods: In this observational study, platelet indices, including IPF, were measured in 105 healthy individuals, 27 patients with hyperdestructive/consumptive thrombocytopenia (all with immune thrombocytopenic purpura [ITP]), and 35 patients with hypoproductive thrombocytopenia (5 with aplastic anemia and 30 with cancer who were undergoing chemotherapy) using a Sysmex XN-3000 hematology analyzer. Read More

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http://dx.doi.org/10.1097/MD.0000000000019096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035018PMC
February 2020
5.723 Impact Factor

Assessment of pre-specified adverse events following varicella vaccine: A population-based self-controlled risk interval study.

Vaccine 2020 Mar 8;38(11):2495-2502. Epub 2020 Feb 8.

Health Data Research Center, National Taiwan University, Taipei, Taiwan.

Background: Clinical trials and spontaneous reporting systems have revealed rare but biologically plausible adverse events following varicella immunization. Few post-marketing controlled studies have been conducted to assess the relationship between the varicella vaccine and these outcomes.

Objectives: To evaluate the risk of pneumonia, idiopathic thrombocytopenic purpura (ITP), meningitis, encephalitis and ischemic stroke following varicella immunization. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.01.090DOI Listing

Bernard-Soulier syndrome or idiopathic thrombocytopenic purpura: A case series.

Authors:
Nahid Reisi

Caspian J Intern Med 2020 ;11(1):105-109

Department of Pediatric Hematology and Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Bernard-Soulier syndrome (BSS) is a rare, autosomal recessive platelet function disorder which is commonly mistaken for idiopathic thrombocytopenic purpura (ITP).The report includes seven cases of BSS that have been diagnosed and treated as ITP for a long time.

Methods: Between 2006 and 2016, data of seven BSS patients who have long been diagnosed and treated as ITP were collected and analyzed. Read More

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http://dx.doi.org/10.22088/cjim.11.1.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992729PMC
January 2020

Fatal fulminant hemolysis-associated pulmonary embolism in mixed-type autoimmune hemolytic anemia: A case report.

Medicine (Baltimore) 2020 Feb;99(6):e18984

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University.

Rationale: Autoimmune hemolytic AQ5 anemia (AIHA) is an immune disorder caused by antibodies directed against unmodified autologous red blood cells. In rare cases, AIHA is comorbid with other immunological disorders; for instance, when AIHA is complicated with immunologic thrombocytopenic purpura (ITP) it is called Evans Syndrome (ES). These multiple autoimmune mechanisms are referred to as "immunological tolerance loss," which is known as a characteristic autoimmunity specific for AIHA. Read More

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http://dx.doi.org/10.1097/MD.0000000000018984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015575PMC
February 2020

Bromocriptine use for sudden peripartum cardiomyopathy in a patient with preeclampsia: a case report.

JA Clin Rep 2019 Jun 7;5(1):38. Epub 2019 Jun 7.

Department of Anesthesiology, Kansai Medical University Hospital, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.

Background: Peripartum cardiomyopathy is an uncommon form of heart failure that occurs in otherwise healthy women during pregnancy or until 5 months postpartum. Here, we report a rare case where a female patient underwent cesarean section after the occurrence of preeclampsia and intrauterine fetal death, and developed peripartum cardiomyopathy following postsurgical respiratory distress. The prompt initiation of inotropic drug and bromocriptine therapy quickly restored cardiac function. Read More

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http://dx.doi.org/10.1186/s40981-019-0256-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966983PMC

[Eltrombopag for the treatment of primary immune thrombocytopenia in 23 pediatric patients].

Zhonghua Xue Ye Xue Za Zhi 2019 Dec;40(12):1031-1034

Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin 300020, China.

To evaluate the efficacy and safety of eltrombopag in the treatment of pediatric primary immune thrombocytopenia (ITP) . The clinical characteristics of 23 pediatric ITP patients who received eltrombopag from May 2015 to March 2019 were retrospectively analyzed. Eltrombopag started with an initial dose of 12. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.12.012DOI Listing
December 2019

[How I treat primary immune thrombocytopenia in pregnancy].

Authors:
L Wang M Hou

Zhonghua Xue Ye Xue Za Zhi 2019 Dec;40(12):977-979

Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.12.001DOI Listing
December 2019

Impact of CD40 gene polymorphisms on the risk of immune thrombocytopenic purpura.

Gene 2020 Apr 1;736:144419. Epub 2020 Feb 1.

Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt.

Objectives: To evaluate the relationship between two common single nucleotide polymorphisms (SNPs) of CD40 gene (rs1883832 C/T and rs4810485 G/T) and the risk of immune thrombocytopenia (ITP) in the Egyptian population.

Methods: A case-control study was conducted retrospectively on 101 cases with ITP and 97 healthy subjects. Two SNPs of CD40 gene (rs1883832 C/T and rs4810485 G/T) were genotyped via Taqman allele discrimination real-time PCR. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144419DOI Listing

[Program for clinical care of immune thrombocytopenic purpura in pregnancy].

Lakartidningen 2020 01 23;117. Epub 2020 Jan 23.

Clintec, Karolinska Institutet - Obstetrics and Gynecology, Karolinska Sjukhuset Huddinge, Sweden Clintec - Obstetrics and Gynecology Huddinge, Sweden.

A program for care of women with immune thrombocytopenic purpura (ITP) with the recommendation to avoid treatment if platelets were >20 × 109/l during pregnancy, with the target level 100 × 109/l at delivery, was introduced. Treatment should be given with intravenous immunoglobulin (IVIG) or corticosteroids. Out of 75 pregnancies with ITP, 39 percent were treated and the treatment period was shorter with IVIG. Read More

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January 2020

5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy.

Geburtshilfe Frauenheilkd 2020 Jan 24;80(1):76-83. Epub 2019 Jul 24.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

To evaluate thrombocytopenic pregnancies including gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), and hypertensive disorders of pregnancy (HDP). We evaluated the pregnancy outcomes and laboratory findings of 385 patients diagnosed with GT, ITP, or HDP whose thrombocyte levels were < 150 000/µL. GT, ITP, and HDP were the final diagnoses in 315 (81. Read More

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http://dx.doi.org/10.1055/a-0865-4442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957351PMC
January 2020

Acute immune trobocytopenic purpura in pregnant adolescent.

Ceska Gynekol 2019 ;84(6):443-449

Objective: The article reviews the causes of thrombocytopenia in pregnancy and the basic examination scheme. Further, it deals in more details with diagnosis of immune thromocytopenic purpura (ITP) and presents a case report of a rare case of acute severe ITP in pregnant adolescent.

Design: Review article and case report. Read More

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January 2020

Idiopathic thrombocytopenic purpura in a patient with situs inversus totalis: case report and literature review.

Einstein (Sao Paulo) 2020 10;18:eRC5111. Epub 2020 Jan 10.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Situs inversus totalis is a rare recessive autosomal congenital abnormality in which the mediastinal and abdominal organs are in a mirrored position when compared to the usual topography. The literature reports some cases of situs inversus totalis and concomitant conditions: spinal abnormalities, cardiac malformations and hematological diseases, such as idiopathic thrombocytopenic purpura, which is an autoimmune disease that causes thrombocytopenia due to platelet destruction or suppression of its production. This article aimed to report the coexistence of situs inversus totalis and idiopathic thrombocytopenic purpura. Read More

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http://dx.doi.org/10.31744/einstein_journal/2020RC5111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924875PMC

[Severe Thrombocitopenia Induced by Fenofibrate].

Acta Med Port 2020 Jan 3;33(1):58-61. Epub 2020 Jan 3.

Serviço de Medicina Interna. Centro Hospitalar Universitário do Algarve. Faro. Portugal.

Drug-induced thrombocytopenia is a common entity in clinical practice. However, having in consideration the severity of the case, it becomes imperative to distinguish non-immune thrombocytopenia from the po-tentially life-threatening immune-mediated forms. The authors report a rare clinical case of a 79-year-old man presenting with purpuric rash and gingival hemorrhage while on fenofibrate treatment (sixth day). Read More

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http://dx.doi.org/10.20344/amp.11354DOI Listing
January 2020

High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura.

Int J Hematol 2020 Mar 2;111(3):388-395. Epub 2020 Jan 2.

Department of Hematology, National Hospital Organization Hiroshimanishi Medical Center, Otake, Japan.

There is a controversy which short term high dose dexamethasone therapy (HDD) or standard dose prednisolone therapy as the initial treatment leads to long term efficacy in idiopathic thrombocytopenic purpura (ITP) patients. We conducted a multicenter, prospective trial to determine the efficacy and safety of short-term HDD in ITP patients aged 18-80 years with platelet counts of < 20 × 10/l, or < 50 × 10/l and bleeding symptoms. The primary endpoints are the proportion of complete response (CR) plus partial response (R) on day 180 after the completion of the 46-day HDD. Read More

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http://dx.doi.org/10.1007/s12185-019-02808-6DOI Listing

Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia.

Oncol Lett 2020 Jan 7;19(1):549-556. Epub 2019 Nov 7.

Division of Hematology-Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.

The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve this, TP53 mRNA levels of 146 children with ALL and 23 child donors with idiopathic thrombocytopenic purpura were determined by reverse transcription-quantitative PCR. Read More

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http://dx.doi.org/10.3892/ol.2019.11064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924105PMC
January 2020

Neutropenia following intravenous immunoglobulin therapy in adult patients with immune thrombocytopenic purpura: A single center experience and literature review.

Medicine (Baltimore) 2020 Jan;99(1):e18624

Division of Hematology-Oncology, Department of Internal Medicine, School of Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

The purpose of this study was to evaluate neutropenia following intravenous immunoglobulin (IVIG) therapy in adults with immune thrombocytopenic purpura (ITP).Our analysis included 88 patients with ITP, who received IVIG from January 2006 to March 2016, at Pusan National University Hospital in Korea. Their white blood cell (WBC) count and absolute neutrophil count (ANC) before and after IVIG treatment were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000018624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946410PMC
January 2020

The clinical effect of Prednisone in combination with Mycophenolate mofetil on idiopathic thrombocytopenic purpura (ITP) and its influence on the level of peripheral blood T lymphocytes and NK lymphocytes.

Saudi J Biol Sci 2019 Dec 12;26(8):2108-2112. Epub 2019 Sep 12.

Department of Pediatrics, Department of Western Medicine, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China.

Objective: To explore he curative effect and safety of Prednisone in combination with Mycophenolate in treating ITP and its influence on the level of peripheral blood T lymphocytes and NK lymphocytes.

Method: 93 cases of ITP patients were divided into the observation group and the control group by the Random Number Table method, 48 cases for the observation group, 45 for another. Patients in the control group orally took 0. Read More

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http://dx.doi.org/10.1016/j.sjbs.2019.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923462PMC
December 2019

[Exploration on connotation of Zhigancao Decoction formula syndrome from the perspective of modern pathophysiology and severe cases of critical care and its clinical efficacy on cardioversion,maintenance of sinus rhythm,hemostasis,increasing platelets count,and tonifying deficiency].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Sep;44(18):3842-3860

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Zhigancao decoction recorded in Treatise on Febrile Disease by Zhang Zhongjing in the Han dynasty have been widely used in treating palpitation and irregular pulse by traditional Chinese medicine physicians for thousands of years. It is all known that Zhigancao Decoction is used to treat consumptive disease. However,why it has been used to treat exogenous febrile disease? According to studies,Fumai Decoctions in Treatise on Differentiation and Treatment of Epidemic Febrile Disease,that was modified based on Zhigancao Decoction,have their names without reality. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190416.501DOI Listing
September 2019

5-Aminolevulinic acid photodynamic therapy and isotretinoin for treatment of drug-induced acne fulminans in a patient with idiopathic thrombocytopenic purpura.

Photodiagnosis Photodyn Ther 2020 Mar 20;29:101630. Epub 2019 Dec 20.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

In this work, we present a case of deteriorative acne that occurred during methylprednisolone and danazol treatment of idiopathic thrombocytopenic purpura (ITP). Treatment of the patient with a combination of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and isotretinoin was satisfactory, though the patient had platelets as low as 4-10 × 10/L during treatment. We consider that the combination of oral isotretinoin and ALA-PDT was effective in this patient may be due to the synergetic effect of these treatments. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.101630DOI Listing

Long-term Successful Treatment of Rituximab for Steroid-resistant Minimal Change Nephrotic Syndrome and Idiopathic Thrombocytopenic Purpura.

Intern Med 2020 Apr 20;59(7):983-986. Epub 2019 Dec 20.

Department of Nephrology, Kurashiki Central Hospital, Japan.

A 22-year-old woman had been diagnosed with idiopathic thrombocytopenic purpura (ITP) 5 years earlier. After undergoing splenectomy, she relapsed frequently following prednisolone tapering. She was complicated with minimal change nephrotic syndrome (MCNS) while taking 20 mg of prednisolone. Read More

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http://dx.doi.org/10.2169/internalmedicine.3837-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184077PMC

Is dapsone still relevant in immune thrombocytopenia in resource limited settings?

BMJ Case Rep 2019 Dec 19;12(12). Epub 2019 Dec 19.

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Immune thrombocytopenia is an autoimmune disorder characterised by autoantibody production against platelets, increased platelet destruction and impaired thrombopoiesis. Steroids are the first-line agents whenever treatment is indicated; however, some patients may not respond and the responders may as well relapse while the dose is being tapered. Side effects of steroids prohibits their long-term use and patients often have to be switched to other agents. Read More

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http://dx.doi.org/10.1136/bcr-2019-232217DOI Listing
December 2019

Evaluation of thrombotic events in patients with immune thrombocytopenia.

Ann Hematol 2020 Jan 18;99(1):49-55. Epub 2019 Dec 18.

Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0431, Japan.

Immune thrombocytopenia (ITP) has been reported to be associated with thrombotic events. The incidence of thrombosis in 303 newly diagnosed ITP patients in our institute between 2000 and 2016 was retrospectively reviewed. During a median follow-up of 3. Read More

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http://dx.doi.org/10.1007/s00277-019-03886-6DOI Listing
January 2020

Disrupted balance of CD4 T-cell subsets in bone marrow of patients with primary immune thrombocytopenia.

Int J Biol Sci 2019 23;15(13):2798-2814. Epub 2019 Oct 23.

Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, P. R. China.

Disequilibrium of CD4 T-cell subpopulations in peripheral blood (PB) of patients with primary immune thrombocytopenia (ITP) has been well established, whereas the profile of CD4 T-cell subpopulations in bone marrow (BM) remains elusive. In the present study, the frequencies of T helper 22 (Th22), Th17, Th1, Th2, follicular T helper (Tfh) cells and regulatory T cells (Tregs) as well as their effector cytokines in BM and PB from active ITP patients and healthy controls (HCs) were determined. Results showed that the frequencies of Th22, Th17, Th1, and Tfh cells were significantly higher, but Treg number was remarkably lower in BM from ITP patients than from HCs. Read More

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http://dx.doi.org/10.7150/ijbs.33779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909963PMC
June 2020
4.509 Impact Factor