116,326 results match your criteria Idiopathic Pulmonary Fibrosis
Respiration 2018 Dec 6:1-10. Epub 2018 Dec 6.
Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial pneumonia that is characterized by stiffness in both the upper lobes and pleura, which is evident on high resolution computed tomography (HRCT) of the chest. However, prognostic factors for IPPFE have not been identified yet.
Objective: We aimed to investigate the clinical prognostic factors affecting survival in patients with IPPFE. Read More
Gait Posture 2018 Nov 20;68:227-231. Epub 2018 Nov 20.
Monash University, School of Primary and Allied Health Care, Frankston, VIC, 3199, Australia; Peninsula Health, Allied Health, 4 Hastings Rd, Frankston, VIC, 3199, Australia.
Background: There remains a substantial lack of evidence to support the use of foot orthoses as a conservative treatment option for idiopathic toe walking (ITW). Encouraging heel contact during gait is one of the primary goals of most interventions in paediatric ITW.
Research Question: Does the combined treatment of high-top boots and orthoses increase the number of heel contacts during gait and change spatio-temporal gait parameters?
Methods: This within subject designed randomised controlled trial recruited fifteen children diagnosed with ITW (n = 10 males). Read More
Gene 2018 Dec 3. Epub 2018 Dec 3.
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No 1. Dr. "Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Gabriel Mancera No. 222, Colonia Del Valle, CP 03100 Ciudad de México, Mexico.
Objective: The renin-angiotensin system (RAS) is a hormonal signaling mechanism implicated in the atherosclerosis and regulation of blood pressure. Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke. The aim of this study was to examine the possible contribution of the I/D in the ACE gene, M235T and T174M in the angiotensinogen (AGT) gene polymorphisms with ischemic stroke in young Mexican population. Read More
Acta Ortop Mex 2018 May-Jun;32(3):145-156
Servicio de Cirugía Ortopédica y Traumatología. Hospital Clínico Universitario de Valencia. Valencia, España.
Background: To quantify the morphological changes in the surface of the back of adolescents with idiopathic scoliosis as a result of treatment with braces and to correlate them with radiographic changes.
Material And Methods: An analytical, cohort, prospective study on a sample of 31 adolescents with idiopathic scoliosis. We divided them into two groups: eleven treated with braces and twenty without them. Read More
Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More
Ugeskr Laeger 2018 Dec;180(49)
Bronchiectasis is characterised by chronic cough, airway inflammation, infection and bronchial dilatation. The disease may lead to impaired lung function and premature death. An underlying inflammatory disease or immunodeficiency may be present, but 40% of the cases are idiopathic. Read More
Proteins 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Nephrology Section, Boston University Medical Center, Boston, MA.
The thrombospondin type-1 domain containing 7A (THSD7A) protein is known to be one of the antigens responsible for the autoimmune disorder idiopathic membranous nephropathy. The structure of this antigen is currently unsolved experimentally. Here we present a homology model of the extracellular portion of the THSD7A antigen. Read More
Intern Emerg Med 2018 Dec 5. Epub 2018 Dec 5.
Institute of Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy.
Int J Comput Assist Radiol Surg 2018 Dec 5. Epub 2018 Dec 5.
Department of Biomedical Engineering, University of Alberta, 1098 Research Transition Facility, 8308-114 Street, Edmonton, AB, T6G 2V2, Canada.
Purpose: Determine the positional, rotational and reconstruction accuracy of a 3D ultrasound system to be used for image registration in navigation surgery.
Methods: A custom 3D ultrasound for spinal surgery image registration was developed using Optitrack Prime 13-W motion capture cameras and a SonixTablet Ultrasound System. Temporal and spatial calibration was completed to account for time latencies between the two systems and to ensure accurate motion tracking of the ultrasound transducer. Read More
Open Med (Wars) 2018 25;13:562-564. Epub 2018 Nov 25.
Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Read More
Multidiscip Respir Med 2018 1;13:43. Epub 2018 Dec 1.
1Regional Referral Centre for Rare Lung Diseases, A.O.U. Policlinico-Vittorio Emanuele, Department of Clinical and Experimental Medicine, University of Catania, via Santa Sofia 78, Catania, Italy.
Background: The assessment of Idiopathic Pulmonary Fibrosis (IPF) using HRCT requires great experience and is limited by a significant inter-observer variability, even between trained radiologists. The evaluation of HRCT through automated quantitative analysis may hopefully solve this problem. The accuracy of CT-histogram derived indexes in the assessment of survival in IPF patients has been poorly studied. Read More
Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.
Vitreous Retina Macula Consultants of New York, New York, NY, USA.
Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).
Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More
Int Heart J 2018 Dec 5. Epub 2018 Dec 5.
Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.
This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More
J Med Genet 2018 Dec 5. Epub 2018 Dec 5.
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.
Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.
Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More
J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.
Abstract: We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil. She maintained this dosage throughout her pregnancy and during the peripartum period, but did not breastfeed her newborn because of a lack of information on the transmission of modafinil in human breast milk. Samples of her breast milk were obtained at various times over a 24-hour period and analyzed using liquid chromatography mass spectrometry. Read More
Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.
Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1774-1777. Epub 2018 Dec 3.
Klinik Schillerhöhe, Abteilung für Pneumologie und Beatmungsmedizin, Gerlingen, Robert-Bosch-Krankenhaus.
Interstitial lung diseases compromise a group of diffuse predominantly chronic inflammatory and fibrosing disorders of the lung parenchyma. This article reviews practice-relevant publications on the diagnosis and treatment of idiopathic pulmonary fibrosis - the most common form of idiopathic interstitial lung diseases. The new patient questionnaire of the German Society of Pneumology facilitates collection of a complex case history of diverse interstitial lung diseases in individual patients. Read More
Sleep Med 2018 Oct 15;53:133-140. Epub 2018 Oct 15.
Institute of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany. Electronic address:
Objective: Patients with chronic excessive daytime sleepiness (EDS) complain of substantial attention deficits. However, their underlying neuronal dysfunction is largely unknown. Previous studies showed similar attention performances in central disorders of hypersomnolence suggesting that EDS-related cognitive impairment is independent of its cause. Read More
Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.
Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.
Department of Rheumatology, Ren Ji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Backgroud: There is an unmet need for the development of new biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD).
Methods: Peripheral CD4+CXCR4+ T cells, stromal cell-derived factor-1 and Krebs von den Lungen-6 were measured in patients with IIM-ILD (n = 85) and controls. The relation to pulmonary functions, high-resolution CT scores, specific clinical phenotypes and survival was analysed. Read More
Curr Opin Otolaryngol Head Neck Surg 2018 Nov 16. Epub 2018 Nov 16.
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Purpose Of Review: Sphenoid sinus lateral recess encephalocoeles (SSLRE) are rare occurrences and pose unique challenges due to limited surgical access for endoscopic endonasal repair and also the lack of consensus on optimal perioperative managements specifically in the spontaneous cases, which are also believed to be a variant of idiopathic intracranial hypertension (IIH). Endoscopic endonasal approaches have largely replaced the transcranial route and the techniques are continuously being refined to reduce the neurovascular morbidity and improve outcome.
Recent Findings: Transpetrygoid is the most utilized approach with modifications suggested to limit bone removal, exposure and preservation of the neurovascular structures as dictated by the extent of the lateral recess. Read More
Clin Spine Surg 2018 Nov 30. Epub 2018 Nov 30.
Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto.
Study Design: Retrospective, single-center, single-surgeon study.
Objective: This study investigated screw perforation rate according to surface registration accuracy in pedicle screw fixation using a CT-based navigation system for adolescent idiopathic scoliosis (AIS).
Summary Of Background Data: Posterior spinal fusion for scoliosis correction using pedicle screws is widely adopted but carries a risk of serious neurovascular or visceral structure events. Read More
Haemophilia 2018 Dec 3. Epub 2018 Dec 3.
Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.
J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.
Department of Radiotherapy, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
Idiopathic pulmonary fibrosis (IPF), characterized by irreversible scarring and progressive destruction of the lung tissue, is one of the most common types of idiopathic interstitial pneumonia worldwide. However, there are no reliable candidates for curative therapies. Hence, elucidation of the mechanisms of IPF genesis and exploration of potential biomarkers and prognostic indicators are essential for accurate diagnosis and treatment of IPF. Read More
Adv Ther 2018 Nov 30. Epub 2018 Nov 30.
Regional Referral Centre for Rare Lung Diseases, Department of Clinical and Experimental Medicine, University Hospital "Policlinico G. Rodolico", University of Catania, Catania, Italy.
Background/objectives: This study will aim to characterise disease behaviour during the peri-diagnostic period in patients with suspected interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), using daily home spirometry and accelerometry. Additionally, this study will aim to increase collaboration between secondary and tertiary centres using a digital collaboration platform.
Methods: The STARLINER study (NCT03261037) will enrol approximately 180 symptomatic patients aged 50 years or more with radiological evidence of ILD/IPF from community and tertiary centres in Canada and Europe. Read More
Clin Auton Res 2018 Nov 30. Epub 2018 Nov 30.
IRCCS Istituto Delle Scienze Neurologiche di Bologna (Italy), UOC Clinica Neurologica, Via Altura 3, 40139, Bologna, Italy.
Purpose: The in vivo diagnosis of synucleinopathies is an important research aim since clinical diagnostic criteria show low accuracy. The skin innervation, especially the autonomic subdivision, is a useful region to search for abnormal α-syn aggregates in synucleinopathies since the peripheral sympathetic nerves can be the earliest-affected neural region and autonomic symptoms may precede the classical symptoms of these disorders.
Methods: The major advantages of skin biopsy as an in vivo diagnostic tool for synucleinopathies are that it is an inexpensive and easy-to-perform technique requiring only limited facilities, and that it is repeatable in long-term studies as it causes only minor discomfort to the patient. Read More
Ophthalmologe 2018 Nov 30. Epub 2018 Nov 30.
Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
Background: Glaucoma due to elevated episcleral venous pressure is a rare and difficult to treat form of secondary open angle glaucoma.
Objective: The pathophysiology, clinical findings, differential diagnosis and treatment options are discussed. Radius-Maumenee syndrome, Sturge-Weber syndrome and carotid-cavernous sinus fistulas are covered in particular. Read More
Rom J Ophthalmol 2018 Jul-Sep;62(3):217-221
Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Serpiginous choroiditis represents an inflammation, often asymmetric, situated at the level of the inner choroid, which is related to the retinal pigment epithelium and the choriocapillaris. It is known as a primarily idiopathic, but there are authors who consider it an autoimmune process. Many times, fundus autofluorescence is the investigation which is guiding the diagnosis, the management, also the follow-up together with the determination of the progressive visual prognosis. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):438-440
Department of Surgical Sciences, Audiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Chondrodermatitis nodularis helicis (CNH) is an idiopathic inflammatory painful condition of the ear characterized by a tender nodule located on the helix or antihelix. Even if various causes have been ascribed, such as a microvascular injury due to acute exposure to cold or trauma, pressure, or rubbing, etiopathogenesis still remains unknown. We describe the unusual case of a young female with a peculiar sequential onset of bilateral CNH in the antihelix region, possibly ascribed to the direct use of mobile phone without earphones. Read More
Transl Androl Urol 2018 Dec;7(6):912-919
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, UK.
Background: To evaluate safety, acceptability and pilot efficacy of transcutaneous low-frequency tibial nerve stimulation (TNS) using a novel device as home-based neuromodulation.
Methods: In this single-centre pilot study, 48 patients with overactive bladder (OAB) (24 with neurogenic and 24 with idiopathic OAB) were randomized to use a self-applicating ambulatory skin-adhering device stimulating transcutaneously the tibial nerve at 1 Hz for 30 minutes, either once daily or once weekly, for 12 weeks. Changes in OAB symptoms and QoL were measured at baseline, weeks 4, 8, and 12 using validated scoring instruments (ICIQ-OAB and ICIQ-LUTSqol), 3-day bladder diary and a Global Response Assessment (GRA) at week 12. Read More
J Thorac Dis 2018 Oct;10(10):5946-5952
Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-pulmonaire, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France.
Heart-lung transplantation (HLTx) is currently the best treatment for patients who have end-stage heart and lung failure. Idiopathic pulmonary arterial hypertension (IPAH) was the main indication for HLTx in the 1980s. However, when studies showed resolution of right ventricular dysfunction after double-lung transplantation (DLTx), this last procedure became the preferred option for end-stage IPAH. Read More
Open Dent J 2018 25;12:827-836. Epub 2018 Oct 25.
Department of Oral And Maxillofacial Surgery, University of Khartoum, Khartoum, Sudan.
Background: Bell's palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15-30 per 100,000.The objective of this work is to study the prevalence and the management of Bell's palsy in the Sudan. Read More
World J Nucl Med 2018 Oct-Dec;17(4):249-252
Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.
The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):297-299
Department of Orbit, Oculoplasty and Ocular Oncology, Giridhar Eye Institute, Kochi, Kerala, India.
Rosai-Dorfman Disease also called as Sinus Histiocytosis with Massive Lymphadenopathy is a rare, benign, idiopathic histiocytic proliferative disorder that occurs predominantly in children and young adults. Orbital involvement can occur in 11% of cases. Isolated lacrimal gland involvement without any local or systemic recurrence is very rare. Read More
Reumatologia 2018 31;56(5):307-315. Epub 2018 Oct 31.
Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.
Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common conditions from which to differentiate in rheumatological care. Read More
Reumatologia 2018 31;56(5):279-284. Epub 2018 Oct 31.
Department of Paediatric Cardiology and Rheumatology, Medical University of Łódź, Poland.
Objectives: The aim of the study was to evaluate the efficacy and long-term safety of tocilizumab treatment in children with systemic-onset juvenile idiopathic arthritis in a single centre.
Material And Methods: The study was based on a retrospective analysis of a cohort of 10 patients with systemic-onset juvenile idiopathic arthritis who were treated with tocilizumab in the period September 2011-July 2017. Their medical records were analysed taking into consideration the effectiveness of tocilizumab treatment and frequency of side effects. Read More
Med Sci Monit 2018 Dec 3;24:8734-8749. Epub 2018 Dec 3.
Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. Read More
Am J Case Rep 2018 Dec 1;19:1430-1433. Epub 2018 Dec 1.
Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
BACKGROUND Idiopathic basal ganglia calcification, also known as Fahr's disease or Fahr's syndrome, is a rare neurological disorder characterized by abnormal calcified deposits in the basal ganglia. Here, we report a case of Fahr's syndrome with calcification of the basal ganglia due to hypoparathyroidism in a patient with seizures. CASE REPORT A 52-year-old male patient visited our clinic with seizures. Read More
Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):318-325
Division of Translational Medicine & Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). Uncontrolled human herpesvirus-8 (HHV-8) infection causes approximately 50% of MCD cases, whereas the etiology is unknown in the remaining HHV-8-negative/idiopathic MCD cases (iMCD). Read More
Transl Oncol 2018 Nov 29;12(2):368-374. Epub 2018 Nov 29.
Nordic Bioscience A/S, Herlev, Denmark.
Objectives: Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon activation. All myofibroblasts express α-SMA, which has been found to be upregulated in lung fibrosis and cancer. Read More
Heart Rhythm 2018 Nov 29. Epub 2018 Nov 29.
Background: The optimal site of ablation of idiopathic left ventricular outflow tract (LVOT) ventricular arrhythmias (VAs) is challenging as activation mapping can reveal similar activation times suggesting an intramural origin.
Objective: We sought to assess whether in patients with intramural VAs and with multiple early activation sites (AS), sequential ablation of all the early AS could improve acute and long term outcomes.
Methods: A total of 116 patients undergoing ablation for symptomatic LVOT VAs were enrolled in this study. Read More
Parkinsonism Relat Disord 2018 Nov 13. Epub 2018 Nov 13.
Department of Neurology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand; Centre for Brain Research, University of Auckland, New Zealand. Electronic address:
Introduction: Regenerative therapies in Parkinson's disease aim to slow neurodegeneration and re-establish damaged neuronal circuitry. Neurotrophins are potent endogenous regulators of neuronal survival, development and regeneration. They represent an attractive regenerative treatment option in Parkinson's disease. Read More
Vaccine 2018 Nov 29. Epub 2018 Nov 29.
Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-１ Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:
Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More
Vet J 2018 Dec 25;242:53-58. Epub 2018 Oct 25.
Department of Clinical Sciences, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Canine idiopathic pulmonary fibrosis (CIPF) affects middle-aged to older dogs of a single breed, mainly the West Highland white terrier (WHWT), which is suggestive of a genetic predisposition. CIPF causes exercise intolerance, restrictive dyspnoea and coughing. Coarse crackles are heard on thoracic auscultation. Read More
J Arthroplasty 2018 Nov 12. Epub 2018 Nov 12.
Aix-Marseille University, CNRS, ISM, Institute of Movement Science, Marseille, France; Department of Orthopaedics and Traumatology, APHM, Sainte Marguerite Hospital, Institute for Locomotion, Marseille, France.
Background: Numerous series have documented short and mid-term successes with cemented, metal-backed modern unicompartmental knee arthroplasty (UKA) for avascular osteonecrosis of the knee (AVN). However, data are lacking regarding long-term implant fixation and patient function. The aim of this study is therefore to evaluate the long-term clinical outcome and implant survivorship of patients who underwent UKA for medial knee osteonecrosis (ON). Read More
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1746-1751
Department of Microbiological immunoplay，Zhanjiang 524023，Guangdong Province, China.
Objective: To detect the expression of JAK2/STAT3 mRNA in peripheral blood T cells from the patients with chronic idiopathic thrombocytopenic purpura（CITP）, and to explore the relationship between JAK2/STAT3 mRNA and CITP.
Methods: CITP group and healthy control group were set in this study, The JAK2/STAT3 mRNA expression level in peropheral blood T cells of 2 groups was detected with the RT-PCR and agarose gel electrophoresis.
Results: JAK2 mRNA expression level in CITP group was significantly higher than that in control group（P<0. Read More
J Neuroinflammation 2018 Nov 30;15(1):333. Epub 2018 Nov 30.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Polo H. San Paolo, via A di Rudinì 8, 20142, Milan, Italy.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, presenting with midbrain dopaminergic neurons degeneration. A number of studies suggest that microglial activation may have a role in PD. It has emerged that inflammation-derived oxidative stress and cytokine-dependent toxicity may contribute to nigrostriatal pathway degeneration and exacerbate the progression of the disease in patients with idiopathic PD. Read More
Med Sci (Basel) 2018 Nov 29;6(4). Epub 2018 Nov 29.
Instituto de Investigación, Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, 28006 Madrid, Spain.
Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is characterized by a chronic, progressive, fibrotic interstitial lung disease of unknown cause that occurs primarily in older adults. Its prevalence and incidence have appeared to be increasing over the last decades. Read More
Genes (Basel) 2018 Nov 29;9(12). Epub 2018 Nov 29.
Biogen, Cambridge, MA 02142, USA.
Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular matrix (ECM) deposition and fibrosis progression in both idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) patient lungs, thus it is critical to understand the transcriptomic and proteomic programs underlying their fibrogenic activity. We conducted the first integrative analysis of the fibrotic programming in these cells at the levels of gene and microRNA (miRNA) expression, as well as deposited ECM protein to gain insights into how fibrotic transcriptional programs culminate in aberrant ECM protein production/deposition. We identified messenger RNA (mRNA), miRNA, and deposited matrisome protein signatures for IPF and SSc fibroblasts obtained from lung transplants using next-generation sequencing and mass spectrometry. Read More