5,321 results match your criteria Idiopathic Intracranial Hypertension


Herpes Simplex Virus-2 Meningitis Masquerading as Pseudotumor Cerebri.

Cureus 2021 Jun 19;13(6):e15764. Epub 2021 Jun 19.

Internal Medicine, Northwestern Medicine McHenry Hospital, Metro Infectious Disease Consultants, McHenry, USA.

We report a case of a 27-year-old obese female presenting with headache, blurry and double vision. She was found to have bilateral papilledema by an ophthalmologist and sent to the emergency department (ED). Cerebrospinal fluid (CSF) analysis showed elevated opening pressure and lymphocytic pleocytosis. Read More

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Intracranial Hypertension Recurrence Risk After Wean of Intracranial Pressure-Lowering Medication.

Pediatr Neurol 2021 Jun 18;121:40-44. Epub 2021 Jun 18.

Department of Ophthalmology, Nationwide Children's Hospital, Columbus, Ohio. Electronic address:

Background: The proportion of children with recurrent signs and symptoms of intracranial hypertension after medication wean has been reported to be between 18% and 50%. Few studies have reported intracranial hypertension recurrence risk in children while adjusting for each individual's observed follow-up time after medication wean. In addition, the role of intracranial hypertension etiology on the risk of disease recurrence has not been widely studied. Read More

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Acute disseminated encephalomyelitis with delayed onset and feasibility of the Miethke shunt and sensor reservoir system: a case report.

Childs Nerv Syst 2021 Jun 16. Epub 2021 Jun 16.

Department of Women's and Children's Health, Uppsala University , Uppsala, Sweden.

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating central nervous system disorder with predilection for early childhood. Delayed onset of ADEM is rare, and herein we present a previously healthy 5-year-old boy, with an unusual clinical course of ADEM with high intracranial pressure (ICP) and acute visual loss that was at first diagnosed as idiopathic intracranial hypertension without papilledema (IIHWOP). The boy underwent acute neurosurgical intervention with ventriculoperitoneal (VP) shunt using Miethke valve and sensor reservoir system and received high-dose steroid treatment with symptom relieve within days. Read More

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The diagnostic dilemma of bilateral optic neuritis and idiopathic intracranial hypertension coexistence in a patient with recent COVID-19 infection.

Clin Case Rep 2021 Jun 10;9(6):e04347. Epub 2021 Jun 10.

Neurosciences Institute Department of Neurology Hamad Medical Corporation Doha Qatar.

Owing to autoantibody production and thrombophilic disorders in COVID-19, physicians must have low threshold to investigate secondary IIH and demyelinating disorders in patients with headache and decreased vision following recent COVID-19 infection. Read More

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Intracranial venous sinus stenting for the treatment of lateral sinus stenoses: An analysis of 200 patients.

Diagn Interv Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Interventional Neuroradiology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France.

Purpose: The purpose of this study was to analyze the long-term efficacy and safety of intracranial venous sinus stenting in a large cohort of patients with any type of presentation of primary lateral venous sinus stenosis (VSS).

Materials And Methods: A retrospective cohort study was performed including patients treated by venous sinus stenting for symptomatic VSS from 2012 to 2019. Successful primary resolution of symptoms without adjunctive treatment or recurrence, and complications after stenting were analyzed at the last follow-up time point. Read More

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Monocular Diplopia in Idiopathic Intracranial Hypertension: A Case Report and Literature Review.

Eur J Case Rep Intern Med 2021 4;8(5):002509. Epub 2021 May 4.

Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

Background: Diplopia is the double vision of a single object, and can be binocular or monocular. Binocular diplopia is caused by the misalignment of the visual axes, with images falling on the fovea of the fixating eye and on the extra-foveal retina of the non-fixating eye, as a consequence of both neurological (i.e. Read More

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Optic disc drusen mimicking Idiopathic Intracranial Hypertension (IIH): rely on ultrasound.

Neurol Res Pract 2021 Jun 14;3(1):33. Epub 2021 Jun 14.

Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Rimini 1, Chaidari, 12462, Athens, Greece.

Optic nerve ultrasound is an established routine supplementary diagnostic tool for idiopathic intracranial pressure but it can also be helpful in avoiding misdiagnoses. We describe a case of an obese 15- year-old girl with persistent headaches, fundoscopic findings suggesting papilledema, normal brain imaging who underwent two lumbar punctures with unremarkable cerebrospinal fluid findings before ultrasound revealed optic disc drusen as the cause of the optic disc elevation. Read More

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Cryopyrin-associated periodic syndrome: a treatable genetic inflammatory condition.

Pract Neurol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, Royal Hobart Hospital, Hobart, Tasmania, Australia

A 20-year-old man presented with recurrent subdural haemorrhages on a background of progressive sensorineural hearing loss, juvenile idiopathic arthritis and intracranial hypertension of unknown cause. His mother had a similar previous history. They both had a persistently mildly elevated serum C reactive protein. Read More

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Effect of changes in optic nerve elasticity on central retinal artery blood flow in patients with idiopathic intracranial hypertension.

J Neuroradiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Faculty of Medicine, Mansoura University, Egypt.

Purpose: To assess changes in central retinal artery (CRA) blood flow by orbital color-coded Doppler ultrasonography in patients with idiopathic intracranial hypertension (IIH) and their relation with optic nerve (ON) elasticity assessed by shear wave elastography (SWE).

Methods: This study was carried out on 68 eyes of patients diagnosed with IIH and 32 eyes of healthy controls. The severity of papilledema in IIH patients was sub-classified into mild and moderate/severe groups. Read More

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Headache attributed to idiopathic intracranial hypertension and persistent post-idiopathic intracranial hypertension headache: A narrative review.

Headache 2021 Jun 9. Epub 2021 Jun 9.

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, UK.

Objective: Headache is a near-universal sequela of idiopathic intracranial hypertension (IIH). The aim of this paper is to report current knowledge of headache in IIH and to identify therapeutic options.

Background: Disability in IIH is predominantly driven by headache; thus, headache management is an urgent and unmet clinical need. Read More

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Coexistence of idiopathic intracranial hypertension and optic disc drusen in a latin american patient: case report.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jun 30;96(6):326-331. Epub 2020 Aug 30.

Departamento de Salud Pública, Universidad de Caldas, Manizales, Colombia.

Optic nerve drusen are acellular concretions of calcium located in the parenchyma of the optical nerve head described as the most common cause of pseudo-papilloedema, which makes it difficult to differentiate from a true optical disc oedema. Despite it being rare, the drusen of the optic nerve and the papilloedema secondary to idiopathic intracranial hypertension can coexist in the same patient. The case is presented of a 34 year-old woman referred to the Ophthalmology Department with visual discomfort, headaches, and pulsatile tinnitus of two months onset. Read More

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Pseudotumor cerebri in the paediatric population: clinical features, treatment and prognosis.

Neurologia 2021 May 31. Epub 2021 May 31.

Unidad de Neurología Pediátrica. Unidad de Gestión Clínica de Pediatría y sus Especialidades. Hospital Universitario Reina Sofía, Córdoba, España; Grupo clínico vinculado al CIBERER, Área de Medicina Metabólica Hereditaria, Instituto de Salud Carlos III, Madrid, España; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, España.

Introduction: Pseudotumor cerebri (PC) in prepubertal patients displays certain characteristics that differentiate it from its presentation at the postpubertal stage. The aim of this study is to describe the characteristics of paediatric patients diagnosed with PC at our centre and to compare them according to their pubertal status.

Patients And Methods: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. Read More

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External cranial expansion as treatment of intracranial hypertension. Technical note.

Neurosurg Rev 2021 Jun 1. Epub 2021 Jun 1.

Department of Neurological Surgery, Regional University Hospital, Malaga, Spain.

Intracranial hypertension may be idiopathic or due to multiple etiologies. Some bone dysplasias and chronic shunt overdrainage syndrome may sometimes lead to intracranial hypertension associated with craniocerebral disproportion due to thickening of cranial diploe. The internal cranial expansion procedure has been used for patients with intracranial hypertension, whether or not associated with craniocerebral disproportion. Read More

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Current Perspectives on Idiopathic Intracranial Hypertension without Papilloedema.

Life (Basel) 2021 May 24;11(6). Epub 2021 May 24.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.

The pseudotumor cerebri syndrome embraces disorders characterised by raised intracranial pressure, where the commonest symptom is headache (90%). Idiopathic intracranial hypertension without papilloedema (IIHWOP) is increasingly recognised as a source of refractory headache symptoms and resultant neurological disability. Although the majority of patients with IIHWOP are phenotypically similar to those with idiopathic intracranial hypertension (IIH), it remains uncertain as to whether IIHWOP is nosologically distinct from IIH. Read More

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Intracranial Venous Hypertension and Venous Sinus Stenting in the Modern Management of Idiopathic Intracranial Hypertension.

Life (Basel) 2021 May 31;11(6). Epub 2021 May 31.

Department of Neurosurgery, Wake Forest University, Winston-Salem, NC 27101, USA.

Idiopathic intracranial hypertension (IIH) is a debilitating condition that has traditionally been difficult to treat. In recent years, there has been increasing focus on the role of intracranial venous hypertension in the pathophysiology of IIH. Based on increased understanding of this pathophysiology, venous sinus stenting (VSS) has emerged as a safe and reliable treatment for a certain population of patients with IIH. Read More

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Magnetic Resonance Imaging Features and Clinical Findings in Pediatric Idiopathic Intracranial Hypertension: A Case-Control Study.

Life (Basel) 2021 May 27;11(6). Epub 2021 May 27.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

The purpose of this study is to identify salient magnetic resonance imaging (MRI) findings of pediatric IIH, to determine the relevance of these findings with regard to disease pathogenesis, and to relate these findings to the clinical presentation towards identification of risk factors of disease. A retrospective, a case-control study of 38 pediatric patients with and 24 pediatric patients without IIH from the ophthalmology department at a tertiary care center was performed. Clinical data, including ophthalmic findings and lumbar puncture results, were recorded. Read More

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Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device.

Life (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Medical Eye Unit, St Thomas' Hospital, London SE1 7EH, UK.

The photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal electroretinography. This study explored the use of a handheld device (RETeval, LKC technologies, Gaithersburg, MD, USA) in 72 IIH patients of varying stages and severity (and seven controls) and investigated associations between PhNR parameters and disease severity. Read More

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Idiopathic Intracranial Hypertension: Evaluation of Admissions and Emergency Readmissions through the Hospital Episode Statistic Dataset between 2002-2020.

Life (Basel) 2021 May 5;11(5). Epub 2021 May 5.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.

With increasing incidence and prevalence of Idiopathic intracranial hypertension in the UK, the aim of this study was to explore emerging themes in Idiopathic intracranial hypertension using the Hospital Episode Statistics dataset and to quantify recent change in hospital admissions and surgeries performed within England.

Methods: Hospital Episode Statistics national data was extracted between 1 April 2002 and 31 March 2019, and followed up until 31 March 2020. All those within England with a diagnosis of Idiopathic Intracranial Hypertension were included. Read More

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Management of cerebrospinal fluid leak: the importance of multidisciplinary approach.

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S18-S29

Otorhinolaryngology, Head and Neck Surgery, "A. Gemelli" Hospital Foundation IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

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Outcomes measures in idiopathic intracranial hypertension.

Expert Rev Neurother 2021 Jun 7;21(6):687-700. Epub 2021 Jun 7.

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom (UK).

: Idiopathic intracranial hypertension is a condition characterized by raised intracranial pressure, papilledema, and normal neuroimaging (aside from radiological signs of raised intracranial pressure). Symptoms of idiopathic intracranial hypertension include chronic headaches and for some, visual loss. New treatments are unmet clinical needs. Read More

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Benign intracranial hypertension associated with inhaled corticosteroids in a child with asthma.

BMJ Case Rep 2021 May 26;14(5). Epub 2021 May 26.

Department of Paediatrics, Children's Health Ireland at Tallaght University Hospital, Dublin, Ireland.

A 13-year-old male asthmatic presented to the general paediatric clinic with papilloedema identified following a check-up with his optician due to blurred vision. His asthma was well controlled on a moderate dose of inhaled corticosteroid and there had been no recent increase or decrease in the dose. A diagnosis of benign intracranial hypertension (BIH) was made based on a raised cerebrospinal fluid opening pressure, papilloedema, a normal neurological examination and normal neuroimaging. Read More

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Dynamic interaction between cerebrospinal fluid and sinovenous pressure in idiopathic intracranial hypertension: a case report.

Br J Neurosurg 2021 May 26:1-3. Epub 2021 May 26.

Department of Neurosurgery, University of Southern California, Los Angeles, CA, USA.

Background: Idiopathic intracranial hypertension (IIH) is a common neurosurgical condition, and the exact pathophysiology remains elusive. Cerebral sinovenous stenosis (CSS) and the resultant decreased venous outflow have been labelled as a potential contributors to the pathophysiology of IIH. We describe the effect of cerebrospinal fluid (CSF) drainage on sinovenous pressure in a patient with IIH and a radiographic evidence of CSS. Read More

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Optic Nerve Sheath Fenestration for Papilledema Due to Cerebral Venous Sinus Thrombosis Associated with Antiphospholipid Syndrome: A Case Report.

Am J Case Rep 2021 May 24;22:e930497. Epub 2021 May 24.

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

BACKGROUND Cerebral venous sinus thrombosis (CVST) is a serious life- and vision-threatening condition that can have a variable presentation according to the site of venous occlusion, including mimicking idiopathic intracranial hypertension. We report on a patient with primary antiphospholipid antibody syndrome (APS) who presented with papilledema due to CVST that was refractory to medical treatment but responded to optic nerve sheath fenestration (ONSF). CASE REPORT A 21-year-old man presented with blurred vision of gradual onset and a progressive course for 1 month, accompanied by fever, headache, and confusion. Read More

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Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression.

Transl Psychiatry 2021 May 21;11(1):308. Epub 2021 May 21.

Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Inflammatory processes involving altered microglial activity may play a relevant role in the pathophysiology of depressive disorders. Glial fibrillary acidic protein (GFAP) and calcium-binding protein S100B are considered microglial markers. To date, their role has been studied in the serum and tissue material of patients with unipolar depression but not in the cerebrospinal fluid (CSF). Read More

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Optic nerve sheath fenestration in leukemic patients having increased intracranial pressure: a prospective clinical trial.

Int Ophthalmol 2021 May 21. Epub 2021 May 21.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: This study aimed to assess the safety and efficacy of optic nerve sheath fenestration (ONSF) in leukemic children having increased intracranial pressure with severe uncontrolled visual loss on medical treatment and not eligible for venous sinus stenting.

Methods: In this non-randomized clinical trial, we included patients presenting with severe sight-threatening papilledema due to increased intracranial pressure following leukemia treatment. All included patients were subjected to a complete history taking, assessment of the visual acuity and fundus examination with fundus photography and grading of papilledema using Frisen scale. Read More

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In Reply: Prepontine Shunting for Pseudotumor Cerebri in Previously Failed Shunt Patients: A 5-Year Analysis.

Neurosurgery 2021 May 20. Epub 2021 May 20.

Department of Neurological Surgery Indiana University School of Medicine Indianapolis, Indiana, USA.

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Emerging role of carbonic anhydrase inhibitors.

Clin Sci (Lond) 2021 May;135(10):1233-1249

Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 500195, Italy.

Inhibition of carbonic anhydrase (CA, EC 4.2.1. Read More

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