5,648 results match your criteria Idiopathic Intracranial Hypertension

Effect of mannitol bolus administration on cerebrospinal fluid pressure in patients with idiopathic intracranial hypertension: a pilot study.

J Neurol 2022 Jun 25. Epub 2022 Jun 25.

Neurology Unit, A.O.U. Mater Domini, Center for Headache and Intracranial Pressure Disorders, Viale Europa, 88100, Catanzaro, Italy.

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Intracranial Hypertension in a Transgender Man.

Neurol Clin Pract 2022 Jun;12(3):275-277

Hauenstein Neurosciences (KQ, SQ, AA), Mercy Health Saint Mary's; and Eye Plastic & Facial Cosmetic Surgery (AH), Grand Rapids, MI.

Objective: Case description of recurrent idiopathic intracranial hypertension (IIH) in a transgender man on gender-affirming hormone therapy.

Methods: Case report.

Results: A 24-year-old transmasculine patient (assigned female at birth), with a body mass index (BMI) of 37. Read More

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Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension-From Physiopathology to Treatment.

Sorin Tuță

Life (Basel) 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Neurology, "Carol Davila" University of Medicine and Pharmacy, 050471 Bucharest, Romania.

In this review, we provide an update on the pathogenesis, diagnosis, and management of adults with idiopathic intracranial hypertension (IIH) and implications of the cerebral venous system, highlighting the progress made during the past decade with regard to mechanisms of the venous outflow pathway and its connection with the cerebral glymphatic and lymphatic network in genesis of IIH. Early diagnosis and treatment are crucial for favorable visual outcomes and to avoid vision loss, but there is also a risk of overdiagnosis and misdiagnosis in many patients with IIH. We also present details about treatment of intracranial hypertension, which is possible in most cases with a combination of weight loss and drug treatments, but also in selected cases with surgical interventions such as optic nerve sheath fenestration, cerebral spinal fluid (CSF) diversion, or dural venous sinus stenting for some patients with cerebral venous sinus stenosis, after careful analysis of mechanisms of intracranial hypertension, patient clinical profile, and method risks. Read More

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Tetracyclines-An Important Therapeutic Tool for Dermatologists.

Int J Environ Res Public Health 2022 Jun 13;19(12). Epub 2022 Jun 13.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland.

Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. Read More

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Non-Invasive Intracranial Pressure Monitoring and Its Applicability in Spaceflight.

Aerosp Med Hum Perform 2022 Jun;93(6):517-531

Neuro-ophthalmic findings collectively defined as Spaceflight-Associated Neuro-ocular Syndrome (SANS) are one of the leading health priorities in astronauts engaging in long duration spaceflight or prolonged microgravity exposure. Though multifactorial in etiology, similarities to terrestrial idiopathic intracranial hypertension (IIH) suggest these changes may result from an increase or impairing in intracranial pressure (ICP). Finding a portable, accessible, and reliable method of monitoring ICP is, therefore, crucial in long duration spaceflight. Read More

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Papilledema and Anemia: A Rare Association.

Cureus 2022 Jun 14;14(6):e25929. Epub 2022 Jun 14.

Neurology, Gopala Gowda Shantaveri Memorial Hospital, Mysore, IND.

Papilledema is the swelling of the optic disc due to the transmission of intracranial pressure through the optic nerve. It can occur as a symptom of various intracranial pathologies that elevate the intracranial pressure. Even though anemia has been described as an association with raised intracranial pressure, the exact causal relationship between the two has not been well established in the literature. Read More

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Coexistence of Idiopathic Intracranial Hypertension with Unilateral Duane Retraction Syndrome Type 1 in an Adult Female.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):292-296. Epub 2022 Apr 22.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Idiopathic intracranial hypertension (IIH) is a poorly understood condition, and its presentation can coexist with other diseases. Simultaneous IIH and Duane retraction syndrome (DRS) type 1 have never been reported to coexist in an adult patient. Herein, we report a 32-year-old obese female with a history of chronic renal failure who had a renal transplant rejection 6 years prior to presentation and was treated with oral steroids and immunosuppressive medications. Read More

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Regression of Bilateral Peripapillary Choroidal Neovascularization Associated with Idiopathic Intracranial Hypertension after Systemic Acetazolamide Treatment.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):270-275. Epub 2022 Apr 19.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

A rare occurrence of bilateral peripapillary choroidal neovascularization (CNV) in an 18-year-old idiopathic intracranial hypertension (IIH) patient regressed with systemic acetazolamide treatment alone. Multimodal imaging was done, including OCT angiography (OCTA), which showed CNV. No injections were given even though she had macular fluid in her left eye. Read More

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Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema.

Cureus 2022 May 11;14(5):e24915. Epub 2022 May 11.

Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA.

Papilledema is a swelling of the optic disc secondary to elevated intracranial pressure (ICP). We analyzed 79 peer-review journal articles and provided a concise summary of the etiology, epidemiology, pathophysiology, clinical presentation, evaluation, natural history, differential diagnosis, treatment, and prognosis of papilledema. Only studies written in English with the full text available were included. Read More

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MRI findings differentiating tonsillar herniation caused by idiopathic intracranial hypertension from Chiari I malformation.

Neuroradiology 2022 Jun 14. Epub 2022 Jun 14.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, WCB90, 330 Brookline Ave, Boston, MB, 02215, USA.

Purpose: Some patients with idiopathic intracranial hypertension (IIH) have cerebellar tonsillar herniation ≥ 5 mm mimicking Chiari malformation I (CMI), which can result in misdiagnosis and unjustified treatment. Our purpose was to identify IIH patients with tonsillar herniation ≥ 5 mm (IIH) and compare with CMI patients to assess imaging findings that could distinguish the two conditions.

Methods: Ninety-eight patients with IIH, 81 patients with CMI, and 99 controls were retrospectively assessed. Read More

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The Potential Significance of Reversed Stapes Reflex in Clinical Practice in Idiopathic Intracranial Hypertension.

Halil Onder

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):214-217. Epub 2022 Jan 13.

Department of Neurology, Yozgat City Hospital, Yozgat, Turkey.

Background: Stapes reflex test is a method of evaluating the involuntary muscle contraction of the stapedius muscle in response to a high-intensity sound stimulus. The formation of this reflex involves the intact function of the 7 nerve, brain stem, 8 nerve, and middle ear. Due to ease of administration and information yielded, the stapedial reflex is considered one of the most powerful differential diagnostic audiological procedures. Read More

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January 2022

Utility of Stapedial Reflex in Idiopathic Intracranial Hypertension: The Proof is in the Pudding.

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):183. Epub 2022 Apr 20.

Department of Neurology, Smt. B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

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Idiopathic Intracranial Hypertension- The Eyes and Beyond.

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):179-180. Epub 2022 Feb 9.

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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February 2022

Life-threatening idiopathic intracranial hypertension: the role of venous sinus stenting.

Childs Nerv Syst 2022 Jun 10. Epub 2022 Jun 10.

Neurosurgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: Idiopathic intracranial hypertension (IIH) is a clinical syndrome characterised by raised intracranial pressure with no discernible aetiology. It is relatively rare in children and its demographic features may differ from those of adults. The relationship between IIH and venous sinus stenosis (VSS) is well known. Read More

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Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases.

Clin Transl Med 2022 Jun;12(6):e885

Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Leptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TME in LM patients compared to controls simultaneously and comprehensively. Read More

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Intraparenchymal pericatheter cyst as an indicator of ventriculoperitoneal shunt malfunction: A case-based update.

Surg Neurol Int 2022 6;13:195. Epub 2022 May 6.

Department of Neurosurgery, Federal University of Ceará, Sobral, Ceará, Brazil.

Background: Intraparenchymal pericatheter cysts (IPCs) are a rare ventriculoperitoneal shunt (VPS) complication, with only a few cases recorded in the literature.

Case Description: We report a 22-year-old woman admitted with headache, papilledema, vision loss, and a history of leukemia. Lumbar puncture revealed idiopathic intracranial hypertension (IIH). Read More

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Chronic CSF leak from lumbar-peritoneal shunt tract: A case report.

Surg Neurol Int 2022 20;13:205. Epub 2022 May 20.

Department of Neurosurgery, NHS, Liverpool, Merseyside, United Kingdom.

Background: We describe a case of long-standing intracranial hypotension caused by an iatrogenic arachnoid diverticulum. This case illustrates two learning points. First, excessive CSF absorption may occur through an acquired arachnoid-epidural venous plexus at a dural defect. Read More

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Idiopathic intracranial hypertension as a neurological manifestation of COVID-19: A case report.

J Fr Ophtalmol 2022 May 18. Epub 2022 May 18.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

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Primary Hypoparathyroidism Presenting as Idiopathic Intracranial Hypertension in a Patient With Barakat Syndrome.

Cureus 2022 Apr 27;14(4):e24521. Epub 2022 Apr 27.

Endocrinology, State University of New York Downstate Medical Center, Brooklyn, USA.

Unlike hyperparathyroidism, hypoparathyroidism is rarely encountered in clinical practice. Usually, it results from surgical resection, an autoimmune phenomenon, or an infiltrative process. Under certain circumstances, one may encounter a genetic etiology of hypoparathyroidism, often combined with myriad other syndromic manifestations. Read More

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The impact of obesity-related raised intracranial pressure in rodents.

Sci Rep 2022 Jun 1;12(1):9102. Epub 2022 Jun 1.

Department of Neurology, Danish Headache Center, Glostrup Research Institute, Rigshospitalet-Glostrup, University of Copenhagen, Nordstjernevej 42, 2600, Copenhagen, Denmark.

Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis in disorders such as idiopathic intracranial pressure (IIH). We investigated the effect of diet induced obesity (DIO) on ICP and clinically relevant sequelae. Read More

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Cerebral angiography as a tool for diagnosis and management of idiopathic intracranial hypertension syndrome.

Clin Imaging 2022 Aug 2;88:53-58. Epub 2022 May 2.

Neurosurgery Section, Universidad del Valle, Cali, Colombia; Neurosurgery Section, Hospital Universitario del Valle, Cali, Colombia.

Purpose: Idiopathic intracranial hypertension syndrome (IIH) is a pathology characterized by headache, visual disturbances, papilledema, increased cerebrospinal fluid pressure with normal cytochemistry that is not attributable to cerebral structural alterations. This study aimed to describe the usefulness of cerebral angiography in the diagnostic approach and management of patients with clinical suspicion of IIH at a fourth level hospital in Cali, Colombia.

Methods: This was a retrospective study. Read More

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Spontaneous Cerebro-Spinal Fluid Rhinorrhoea Caused by Sustained Intracranial Hypertension.

Cureus 2022 Apr 24;14(4):e24441. Epub 2022 Apr 24.

Emergency Department, Hamad Medical Corporation, Doha, QAT.

Cerebrospinal Fluid (CSF) leakage results from a defect in the skull base, which communicates the subarachnoid space with the nasal cavity. The most common cause of CSF leakage is traumatic, and non-traumatic causes are less common. This case report illustrates a case of a woman who presented to the emergency department with clear fluid pouring from her nose for three weeks with a fever. Read More

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Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset.

BJOG 2022 May 27. Epub 2022 May 27.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Objective: Idiopathic intracranial hypertension (IIH) predominantly affects women of reproductive age with obesity, and these women have a distinct profile of hyperandrogenism and insulin resistance. Polycystic ovary syndrome (PCOS) has an established adverse fertility phenotype that typically affects obese women. As IIH may impact reproductive health, we sought to evaluate fertility, gestational complications and pregnancy outcome in IIH. Read More

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Measuring optic nerve sheath diameter using ultrasonography in patients with idiopathic intracranial hypertension.

Arq Neuropsiquiatr 2022 May 20. Epub 2022 May 20.

Beytepe Murat Erdi Eker State Hospital, Department of Neurology, Çankaya, Ankara, Turkey.

Background: Idiopathic intracranial hypertension (IIH) is primarily a disorder of obese young women characterized by symptoms associated with raised intracranial pressure in the absence of a space-occupying lesion.

Objective: To compare the mean optic nerve sheath diameter (ONSD) measured using ultrasonography (USG) in patients with idiopathic intracranial hypertension (IIH) and normal healthy individuals.

Methods: A prospective study. Read More

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Long-Term Outcomes of Bariatric Surgery in Idiopathic Intracranial Hypertension Patients.

Neurologist 2022 May 19. Epub 2022 May 19.

Intracranial Hypertension Registry, Casey Eye Institute.

Background: Idiopathic intracranial hypertension (IIH), a rare neurological disorder, has limited effective long-term treatments. Bariatric surgery has shown short-term promise as a management strategy, but long-term efficacy has not been evaluated. We investigated IIH-related outcomes 4 to 16 years postsurgery. Read More

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Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension.

Eur J Endocrinol 2022 May 1. Epub 2022 May 1.

A Sinclair, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Context Idiopathic intracranial hypertension (IIH) is a disease of raised intracranial pressure (ICP) of unknown aetiology. Reductions in glucocorticoid metabolism are associated with improvements in IIH disease activity. The basal IIH glucocorticoid metabolism yet to be assessed. Read More

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Evaluation Of Clinical Findings With MRI Venography In Patients With Idiopatic Intracranial Hypertension.

Curr Med Imaging 2022 May 16. Epub 2022 May 16.

Kırşehir Ahi Evran University Medical Faculty,Department of Radiology, Kırşehir, Turkey.

Objectives: To evaluate clinical data and Magnetic Resonance Venography (MRV) findings together in patients with idiopathic intracranial hypertension (IIH) Materials and Methods: In this retrospective study Between January 2009 and February 2021, conventional MRI and MRV examinations were performed in 30 patients who were admitted to the neurology service of our hospital with the pre-diagnosis of IIH, cerebrospinal fluid (CSF) pressure was measured in these patients to confirm the diagnosis of IIH. Transverse Sinus Stenosis Ratio (TS SR), Superior Sagittal Sinus (SSS) diameter, Sinus Rectus (SR) diameter, Stenosis Segment Length (SSL), were studied.

Results: High CSF pressure was detected in 22 of 30 patients with IIH pre-diagnosis. Read More

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Clinical and Radiological Profile of 122 Cases of Idiopathic Intracranial Hypertension in a Tertiary Care Centre of India: An Observational Study.

Neurol India 2022 Mar-Apr;70(2):704-709

Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Background: Idiopathic intracranial hypertension (IIH) is well-described entity in literature. However, large studies on clinical and radiological profile are still very few from the Indian subcontinent.

Aims: To analyze the clinical and radiological profile of IIH and correlation of various clinical and radiological parameters with papilledema and CSF opening pressure. Read More

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Idiopathic intracranial hypertension in atypical demographics.

J Neurol Sci 2022 Jun 29;437:120271. Epub 2022 Apr 29.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is a condition that most often occurs in women of reproductive age with elevated body mass index (BMI) (typical patients). Individuals outside of this demographic group (atypical patients) may have a different pathophysiology underlying raised intracranial pressure (ICP) leading to unique clinical presentations and prognosis.

Methods: Retrospective chart review of patients with IIH in typical and atypical demographic groups: men, those diagnosed at age 40 or older and those with BMI <26. Read More

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