4,736 results match your criteria Idiopathic Intracranial Hypertension


Assessment of the Olfactory Function in Patients With Idiopathic Intracranial Hypertension Using the Sniffin' Sticks Test: A Case-Control Study.

Headache 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: Despite the lack of recognition in clinical practice, there is increasing evidence that patients with idiopathic intracranial hypertension may suffer from hyposmia. The current case-control study aims to evaluate olfactory dysfunction in a large series of patients with idiopathic intracranial hypertension.

Methods: All subjects, 44 idiopathic intracranial hypertension patients and 57 healthy controls, underwent olfactory function assessment using standardized "Sniffin' Sticks" test at a tertiary referral center of a university hospital. Read More

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http://dx.doi.org/10.1111/head.13538DOI Listing

Intracranial Venous Sinus Stenting: A Review of Idiopathic Intracranial Hypertension and Expanding Indications.

Cureus 2019 Feb 4;11(2):e4008. Epub 2019 Feb 4.

Neurosurgery, Penn State Milton Health S. Hershey Medical Center, Hershey, USA.

Idiopathic intracranial hypertension (IIH) is a functionally limiting disorder secondary to increased intracranial pressures (ICPs) with a prevalence of one per 100,000 persons. It is estimated to cost >$400 million per year in productively. Symptoms classically consist of chronic headaches, papilledema, and visual loss. Read More

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http://dx.doi.org/10.7759/cureus.4008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450594PMC
February 2019

Concurrent Venous Stenting of the Transverse and Occipito-Marginal Sinuses: An Analogy with Parallel Hemodynamic Circuits.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):334-338

Department of Neurosurgery, Pennsylvania State University, Hershey, Pennsylvania, USA.

Nonthrombotic intracranial venous occlusive disease (NIVOD) has been implicated in the pathophysiology of idiopathic intracranial hypertension (IIH) and various non-IIH headache syndromes. Endovascular stenting of stenotic, dominant transverse sinuses (TSs) may reduce trans-stenosis pressure gradients, decrease intracranial pressure, and alleviate symptoms in a subset of NIVOD patients. We present a case in which concurrent stenting of the occipito-marginal sinus obliterated the residual trans-stenosis pressure gradient across an initially stented dominant TS. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_259_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454934PMC

Idiopathic intracranial hypertension presenting with isolated unilateral facial nerve palsy: a case report.

J Med Case Rep 2019 Apr 19;13(1):94. Epub 2019 Apr 19.

Neurology Department, University of Minnesota, Minneapolis, MN, USA.

Background: Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is a disorder characterized by increased intracranial pressure of unclear pathogenesis in the absence of other structural and obstructive lesions that is predominantly, although not exclusively, seen in obese women of childbearing age. Patients with idiopathic intracranial hypertension commonly present with a headache, transient visual obscurations, and intracranial noises with some cranial nerves occasionally involved, most commonly CN VI. We report idiopathic intracranial hypertension presenting with isolated complete unilateral facial nerve palsy, as the sole cranial nerve involved, which is a presentation rarely reported in the literature. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-019-2060-5DOI Listing
April 2019
1 Read

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies.

Front Immunol 2019 21;10:515. Epub 2019 Mar 21.

Department of Neurology, Institute of Translational Neurology, University of Münster, Münster, Germany.

Utilize immune cell profiles in the cerebrospinal fluid (CSF) to advance the understanding and potentially support the diagnosis of inflammatory neuropathies. We analyzed CSF cell flow cytometry data of patients with definite Guillain-Barré syndrome (GBS, = 26) and chronic inflammatory demyelinating polyneuropathy (CIDP, = 32) based on established diagnostic criteria in comparison to controls with relapsing-remitting multiple sclerosis (RRMS, = 49) and idiopathic intracranial hypertension (IIH, = 63). Flow cytometry revealed disease-specific changes of CSF cell composition with a significant increase of NKT cells and CD8+ T cells in CIDP, NK cells in GBS, and B cells and plasma cells in MS in comparison to IIH controls. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448021PMC
March 2019
1 Read

Irreversibility of transverse venous sinus stenosis and optic nerve edema post-lumbar puncture in idiopathic intracranial hypertension.

Can J Ophthalmol 2019 Apr 25;54(2):e57-e59. Epub 2018 Aug 25.

Department of Diagnostic Radiology, Dalhousie University, Halifax, N.S., Canada.

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http://dx.doi.org/10.1016/j.jcjo.2018.06.023DOI Listing
April 2019
1 Read

Idiopathic intracranial hypertension.

Authors:
Elizabeth Boyter

JAAPA 2019 Apr 8. Epub 2019 Apr 8.

Elizabeth Boyter practices neurology with Laureate Medical Group at Northside in Atlanta, Ga. The author has disclosed no potential conflicts of interest, financial or otherwise.

Idiopathic intracranial hypertension is a rare disorder of elevated intracranial pressure with normal cerebrospinal fluid composition and without intracranial pathology. This condition primarily affects obese women of childbearing age and frequently causes headaches, vision loss, diplopia, tinnitus, and nausea. The incidence of idiopathic intracranial hypertension is rising along with obesity rates. Read More

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http://dx.doi.org/10.1097/01.JAA.0000554732.85914.91DOI Listing

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases.

Fluids Barriers CNS 2019 Apr 10;16(1). Epub 2019 Apr 10.

Brain Barriers Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Medical Sciences Building, University Drive, Callaghan, NSW, 2308, Australia.

The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A significant disruption to the normal CSF circulation can be life threatening, leading to increased intracranial pressure (ICP), and is implicated in hydrocephalus, idiopathic intracranial hypertension, brain trauma, brain tumours and stroke. Read More

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https://fluidsbarrierscns.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12987-019-0129-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456952PMC
April 2019
5 Reads

Endovascular stenting of the superior sagittal sinus to alleviate venous compression caused by a parasagittal meningioma.

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Department of Neurosurgery, Albany Medical Center, Albany, New York, USA.

Idiopathic intracranial hypertension (IIH) is a challenging disease with unclear pathophysiology. Recognition of venous sinus stenting to improve intracranial pressure is increasing.We present a 56-year-old man diagnosed with IIH. Read More

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http://dx.doi.org/10.1136/bcr-2018-227935DOI Listing

Management of Peripapillary Choroidal Neovascular Membrane in Patients With Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology (CO), Gulhane Training and Research Hospital, Ankara, Turkey; Department of Ophthalmology and Visual Sciences (OM, LBD, WTC, CGB), W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan; Department of Ophthalmology (MM), Mid-Atlantic Permanente Medical Group, Rockville, Maryland; Department of Ophthalmology and Visual Neurosciences (MSL), University of Minnesota, Minneapolis, Minnesota; Department of Ophthalmology and Neurology Mayo Clinic (MTB), Rochester, Minnesota; Department of Ophthalmology (KL), University Hospital Zurich and University of Zurich, Zurich, Switzerland; Department of Ophthalmology (GPVS), Washington University in St. Louis, St. Louis, Missouri; Department of Ophthalmology (DDM), Indiana University School of Medicine, Indianapolis, Indiana; Department of Ophthalmology (ML), Hôpital Delafontaine, Saint-Denis, France; and Department of Neurology (LBD, WTC), University of Michigan, Ann Arbor, Michigan.

Objective: To report the clinical features and treatment outcomes of patients with peripapillary choroidal neovascular membrane (CNVM) secondary to idiopathic intracranial hypertension (IIH).

Methods: Retrospective, multicenter chart review of patients diagnosed with peripapillary CNVM in the course of the treatment and follow-up of IIH.

Results: Records were reviewed from 7 different institutions between 2006 and 2016. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000781DOI Listing

Endovascular stenting for idiopathic intracranial hypertension with venous sinus stenosis.

Brain Behav 2019 Apr 4:e01279. Epub 2019 Apr 4.

Department of Neurology, Chinese PLA General Hospital, Beijing, China.

Objectives: Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure of unknown etiology and venous sinus stenting may be an optional treatment. We aimed to evaluate the effects of venous sinus stenting on visual function, intracranial pressure, and trans-stenotic pressure gradient of the patients with IIH and to determine effects of baseline BMI or weight changes on subjective vision outcome and intracranial pressure.

Methods: From July 2009 to Aug 2016, 88 eligible patients with IIH and venous sinus stenosis who underwent stenting were retrospectively studied. Read More

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http://dx.doi.org/10.1002/brb3.1279DOI Listing
April 2019
1 Read

Spinal CSF flow in response to forced thoracic and abdominal respiration.

Fluids Barriers CNS 2019 Apr 4;16(1):10. Epub 2019 Apr 4.

Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, 37075, Göttingen, Germany.

Background: Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present study was to elucidate the sensitivity of CSF flow along the spinal canal to forced thoracic versus abdominal respiration.

Methods: Eighteen subjects without known illness were studied using real-time phase-contrast flow MRI at 3 T in the aqueduct and along the spinal canal at levels C3, Th1, Th8 and L3. Read More

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http://dx.doi.org/10.1186/s12987-019-0130-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449937PMC

From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM.

Metab Brain Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Medical Biochemistry, Acibadem University, Istanbul, Turkey.

Here we review tumoricidal efficacy of Vitamin D analogues in glioblastoma multiforme (GBM) and potential synergisms with retinoic acid and temozolomide based on epidemiological and cellular studies. Epidemiological data suggest that winter birth is associated with higher risk of GBM, and GBM debulking in the winter enhanced mortality, which may relate with lower exposure to sunlight essential to convert cholecalciferol to Vitamin D. Comparative studies on blood bank specimens revealed that higher prediagnosis levels of calcidiol are associated with lower risk of GBM in elderly men. Read More

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http://dx.doi.org/10.1007/s11011-019-00412-5DOI Listing

Lumboperitoneal and Ventriculoperitoneal Shunting for Idiopathic Intracranial Hypertension Demonstrate Comparable Failure and Complication Rates.

Neurosurgery 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, California.

Background: Idiopathic intracranial hypertension results in increased intracranial pressure leading to headache and visual loss. This disease frequently requires surgical intervention through lumboperitoneal (LP) or ventriculoperitoneal (VP) shunting.

Objective: To compare postoperative outcomes between LP and VP shunts, including failure and complication rates. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyz080DOI Listing
April 2019
6 Reads
3.620 Impact Factor

The significance of intra-abdominal pressure in neurosurgery and neurological diseases: a narrative review and a conceptual proposal.

Acta Neurochir (Wien) 2019 Mar 25. Epub 2019 Mar 25.

Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.

Intra-abdominal pressure (IAP) is a physiological parameter that has gained considerable attention during the last few decades. The incidence of complications arising from increased IAP, known as intra-abdominal hypertension (IAH) or abdominal compartment syndrome in critically ill patients, is high and its impact is significant. The effects of IAP in neurological conditions and during surgical procedures are largely unexplored. Read More

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http://link.springer.com/10.1007/s00701-019-03868-7
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http://dx.doi.org/10.1007/s00701-019-03868-7DOI Listing
March 2019
12 Reads

Biopsy-proven primary angiitis of the central nervous system mimicking leukodystrophy: A case report and review of the literature.

J Clin Neurosci 2019 Mar 22. Epub 2019 Mar 22.

Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico "C. Besta", Via Celoria 11, 20133 Milan, Italy.

Primary Angiitis of the Central Nervous System (PACNS) is a rare form of idiopathic CNS vasculitis. Neuroimaging is often abnormal and characterized by multifocal brain lesions, but brain biopsy definitely confirms the diagnosis. We report the rare case of a 45-year-old female presenting with symptoms of intracranial hypertension and leukodystrophy-like neuroimaging findings. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.021DOI Listing
March 2019
1 Read

Association Between Cycline Antibiotic and Development of Pseudotumor Cerebri Syndrome.

J Am Acad Dermatol 2019 Mar 21. Epub 2019 Mar 21.

The Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN. Electronic address:

Background: Cycline antibiotics (CA) are commonly used to treat acne, blepharitis, and dry eye syndrome (DES). Prescribers or patients may hesitate to use CAs, since they may increase the risk of pseudotumor cerebri syndrome (PTCS).

Objective: To assess whether CA use is associated with an increased risk of PTCS or papilledema and whether the risk depends upon dosage or duration of CA intake. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.041DOI Listing
March 2019
2 Reads

Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria.

J Stroke Cerebrovasc Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Background: Data on the clinical and radiological characteristics of intracranial artery dissection (IAD) have remained limited. Our purpose was to reveal the clinical and radiological characteristics of IAD according to diagnostic criteria for IAD as recently reported by a group of international experts.

Methods: Patients were retrospectively enrolled using a prospective single-center stroke registry between 2011 and 2016. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.019DOI Listing
March 2019
2 Reads

What are the research priorities for idiopathic intracranial hypertension? A priority setting partnership between patients and healthcare professionals.

BMJ Open 2019 Mar 15;9(3):e026573. Epub 2019 Mar 15.

Department of Metabolic Neurology, University of Birmingham, Birmingham, UK.

Objective: Idiopathic intracranial hypertension (IIH) is under-researched and the aim was to determine the top 10 research priorities for this disease.

Design: A modified nominal group technique was used to engage participants who had experience of IIH.

Setting: This James Lind Alliance Priority Setting Partnership was commissioned by IIH UK, a charity. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429891PMC

Headache attributed to IIH: clinical evolution in IHS criteria through the years.

Neurol Sci 2019 Mar 16. Epub 2019 Mar 16.

Casa di Cura del Policlinico, Igea Headache Center, Via Marcona, 69, Milan, Italy.

Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure without a detectable cause. The most common symptom of IIH is a headache, which occurs in almost all cases at the time of diagnosis with various headache phenotypes. In clinical practice, diagnosis of headache attributed to IIH is given referring to the International Headache Society (IHS) criteria of the International Classification of Headache Disorders. Read More

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http://dx.doi.org/10.1007/s10072-019-03795-6DOI Listing

Tip of the iceberg in idiopathic intracranial hypertension.

Pract Neurol 2019 04;19(2):178-179

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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http://dx.doi.org/10.1136/practneurol-2019-002198DOI Listing
April 2019
2 Reads

Indication to use a non-pencil-point lumbar puncture needle.

Pract Neurol 2019 04;19(2):176-177

Neuro-Ophthalmology Clinic, St Vincent's Public Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1136/practneurol-2018-002103DOI Listing
April 2019
1 Read

Endovascular treatment of debilitating tinnitus secondary to cerebral venous sinus abnormalities: a literature review and technical illustration.

J Neurointerv Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, The University of Hong Kong, Hong Kong.

Background And Objective: Pulsatile tinnitus (PT) can be debilitating and lead to significant morbidity. Cerebral venous sinus lesions, such as venous sinus stenosis, diverticula, and high-riding jugular bulb, are uncommon causes of PT, for which there is no standard treatment. Endovascular interventions have shown promising results for PT secondary to idiopathic intracranial hypertension, and may be a valid therapeutic option for isolated venous PT. Read More

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http://dx.doi.org/10.1136/neurintsurg-2019-014725DOI Listing

IDIOPATHIC INTRACRANIAL HYPERTENSION: A UNIQUE ETIOLOGY OF PSEUDOMENINGOCELE AND RESULTANT EMPTY SELLA AND CSF RHINORRHEA.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

Division of Endocrinology, San Antonio Uniformed Services Health Education Consortium, San Antonio, Texas.

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http://dx.doi.org/10.4158/EP-2019-0096DOI Listing
March 2019
1 Read

Novel advances in monitoring and therapeutic approaches in idiopathic intracranial hypertension.

Curr Opin Neurol 2019 Mar 6. Epub 2019 Mar 6.

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital.

Purpose Of Review: The current article appraises the recent developments in idiopathic intracranial hypertension (IIH), with particular attention to novel therapeutic avenues and advanced clinical assessment and monitoring with optical coherence tomography and telemetric intracranial pressure devices.

Recent Findings: The incidence of IIH is increasing. The first consensus guidelines for IIH have been published detailing investigation and management algorithms for adult IIH. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000690DOI Listing
March 2019
1 Read

Retinal Nerve Fiber Layer Thickness Decrease in Obesity as a Marker of Neurodegeneration.

Obes Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, Centro Hospitalar de São João, Porto, Portugal.

Background: Idiopathic intracranial hypertension (IIH) is a serious condition that is frequently associated with irreversibly vision loss, having a higher incidence among obese women. Our aims were to screen subclinical IIH in obese patients scheduled to bariatric surgery using peripapillary retinal nerve fiber layer (RNFL) thickness and to evaluate if the findings demand the possible need of a preoperative evaluation in this population.

Methods: This study included 111 eyes from 36 obese patients (86% female, body mass index > 35 kg/m) scheduled to bariatric surgery and 20 non-obese (body mass index < 25 kg/m) age-matched controls. Read More

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http://link.springer.com/10.1007/s11695-019-03806-7
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http://dx.doi.org/10.1007/s11695-019-03806-7DOI Listing
March 2019
9 Reads

Bibliometric analysis of the top-cited articles on idiopathic intracranial hypertension.

Neurol India 2019 Jan-Feb;67(1):78-84

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: To identify and characterize the top-cited articles on idiopathic intracranial hypertension.

Methods: We used "Web of Science database" to identify the top-cited articles published between the years of 1975-2017. The articles were evaluated using citation count and other factors that have an effect on the citation count. Read More

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http://dx.doi.org/10.4103/0028-3886.253969DOI Listing
March 2019
1 Read

Emergency department utilization among individuals with idiopathic intracranial hypertension.

Int J Health Care Qual Assur 2019 Feb;32(1):152-163

Casey Eye Institute, Oregon Health and Science University , Portland, Oregon, USA.

Purpose: Idiopathic intracranial hypertension (IIH) can be a debilitating disorder that is difficult to identify and treat. Failure to adequately manage IIH symptoms may force patients to present at emergency departments (EDs) seeking symptom relief. The purpose of this paper is to empirically characterize ED use by previously diagnosed IIH patients. Read More

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http://dx.doi.org/10.1108/IJHCQA-04-2017-0060DOI Listing
February 2019
1 Read

Idiopathic intracranial hypertension in a transgender female.

Can J Ophthalmol 2019 Feb 21;54(1):e35-e38. Epub 2018 Jun 21.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY; Section of Ophthalmology, University of Texas MD Anderson Cancer Center, Houston, TX; Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA.

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http://dx.doi.org/10.1016/j.jcjo.2018.04.021DOI Listing
February 2019

Periventricular white matter changes in idiopathic intracranial hypertension.

Ann Clin Transl Neurol 2019 Feb 18;6(2):233-242. Epub 2019 Jan 18.

Department of Medical and Surgical Sciences Center for Headache and Intracranial Pressure Disorders Institute of Neurology Magna Græcia University of Catanzaro Catanzaro Italy.

Objective: To evaluate whether increased cerebrospinal fluid (CSF) pressure causes alteration of periventricular white matter (WM) microstructure in patients with idiopathic intracranial hypertension (IIH).

Methods: In a prospective study, patients with refractory chronic headache with and without IIH performed a neuroimaging study including 3T MRI, 3D Phase Contrast MR venography, and diffusion tensor imaging (DTI) of the brain. Whole-brain voxel-wise comparisons of DTI abnormalities of WM were performed using tract-based spatial statistics. Read More

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http://dx.doi.org/10.1002/acn3.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389746PMC
February 2019
2 Reads

Endovascular Stenting in a Transgender Patient With Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2019 Mar 4. Epub 2019 Mar 4.

Doheny Eye Institute (KK, RK, AAS), Los Angeles, California; Huntington Memorial Hospital (AK), Pasadena, California; Department of Ophthalmology (RK, AAS), Doheny Eye Center, David Geffen School of Medicine at UCLA, Los Angeles, California; The Ottawa Eye Institute (RK), University of Ottawa, Ottawa, Canada; and Ottawa Hospital Research Institute (RK), Ottawa, Canada.

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http://dx.doi.org/10.1097/WNO.0000000000000752DOI Listing
March 2019
8 Reads

Dural sinus collapsibility, idiopathic intracranial hypertension, and the pathogenesis of chronic migraine.

Neurol Sci 2019 Mar 6. Epub 2019 Mar 6.

Istituto di Diagnosi e Cura Hermitage Capodimonte, Naples, Italy.

Available evidences suggest that a number of known assumption on idiopathic intracranial hypertension (IIH) with or without papilledema might be discussed. These include (1) the primary pathogenetic role of an excessive dural sinus collapsibility in IIH, allowing a new relatively stable intracranial fluids pressure balance at higher values; (2) the non-mandatory role of papilledema for a definite diagnosis; (3) the possibly much higher prevalence of IIH without papilledema than currently considered; (4) the crucial role of the cerebral compliance exhaustion that precede the raise in intracranial pressure and that may already be pathologic in cases showing a moderately elevated opening pressure; (5) the role as "intracranial pressure sensor" played by the trigeminovascular innervation of dural sinuses and cortical bridge veins, which could represent a major source of CGRP and may explain the high comorbidity and the emerging causative link between IIHWOP and chronic migraine (CM). Accordingly, the control of intracranial pressure is to be considered a promising new therapeutic target in CM. Read More

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http://dx.doi.org/10.1007/s10072-019-03775-wDOI Listing
March 2019
4 Reads

Trocar assisted distal shunt tube insertion with intra-operative X-Ray confirmation.

Br J Neurosurg 2019 Mar 5:1-4. Epub 2019 Mar 5.

a Department of Neurosurgery , Dr. Soliman Fakeeh Hospital , Jeddah , Saudi Arabia.

Trocar assisted distal shunt catheter placement could be an alternative to mini-laparotomy or laporoscopy with good results in comparison to other procedures.

Objects: We report our experience with trocar assisted distal shunt tube placement with intraoperative x-ray to rule-out misplacement.

Methods: Patients having peritoneal distal catheter site placement for ventriculo-peritoneal or lumbo-peritoneal shunts presenting to Dr. Read More

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http://dx.doi.org/10.1080/02688697.2019.1579890DOI Listing
March 2019
3 Reads

Safety and efficacy of intravascular ultrasound as an adjunct to stenting for cerebral venous sinus stenosis-induced idiopathic intracranial hypertension: a pilot study.

J Neurosurg 2019 Mar 1:1-6. Epub 2019 Mar 1.

Departments of1Neurosurgery.

OBJECTIVESymptomatic intracranial hypertension can be caused by cerebral venous sinus stenosis (CVSS) and cerebral venous sinus thrombotic (CVST) stenosis, which is usually found in some patients with idiopathic intracranial hypertension (IIH). Recently, at the authors' center, they utilized intravascular ultrasound (IVUS) as an adjunct to conventional venoplasty or stenting to facilitate diagnosis and accurate stent placement in CVSS.METHODSThe authors designed a retrospective review of their prospective database of patients who underwent IVUS-guided venous sinus stenting between April 2016 and February 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS181885DOI Listing
March 2019
3 Reads

Idiopathic intracranial hypertension presenting as bilateral spontaneous lateral intrasphenoidal and transethmoidal meningoceles: a case report and review of the literature.

J Med Case Rep 2019 Mar 5;13(1):62. Epub 2019 Mar 5.

Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Room C2218, Ottawa, Ontario, K1Y 4E9, Canada.

Background: Basal meningoceles are rare herniations of the meninges that tend to present unilaterally with cerebrospinal fluid rhinorrhea. Growing evidence suggests that intracranial hypertension contributes considerably to the formation of spontaneous basal meningoceles.

Case Presentation: A 50-year-old man of Middle East ethnicity presented with a 16-week history of cerebrospinal fluid rhinorrhea, short-term memory loss, and slight decline in cognitive function. Read More

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http://dx.doi.org/10.1186/s13256-018-1959-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399895PMC
March 2019
2 Reads

Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema.

J Neuroophthalmol 2019 Feb 26. Epub 2019 Feb 26.

Department of Neurology (RMM), Brigham and Women's Hospital, Boston, Massachusetts; Department of Ophthalmology (RMM), Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; East Tennessee Medical Group-Neurology (OFR), Blount Memorial Hospital, Maryville, Tennessee; Department of Radiology (JHW, YJC), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Texas Neurology Consultants (SR), Texas Health Resources, Plano, Texas; Department of Radiology (KLS, LL), University of Utah School of Medicine, Salt Lake City, Utah; Department of Radiology (MCP), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Ophthalmology (MAT, KSS, GTL), University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania; Departments of Ophthalmology and Neurology (KBD), University of Utah School of Medicine, Salt Lake City, Utah; Departments of Neurology and Neurotherapeutics and Ophthalmology (DIF), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Neurology (MAT, KSS, GTL), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and Division of Ophthalmology (GTL), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Objective: Revised diagnostic criteria for idiopathic intracranial hypertension (IIH) were proposed in part to reduce misdiagnosis of intracranial hypertension without papilledema (WOP) by using 3 or 4 MRI features of intracranial hypertension when a sixth nerve palsy is absent. This study was undertaken to evaluate the sensitivity and specificity of the MRI criteria and to validate their utility for diagnosing IIH in patients with chronic headaches and elevated opening pressure (CH + EOP), but WOP.

Methods: Brain MRIs from 80 patients with IIH with papilledema (WP), 33 patients with CH + EOP, and 70 control patients with infrequent episodic migraine were assessed in a masked fashion for MRI features of intracranial hypertension. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000767DOI Listing
February 2019
6 Reads

Previously Diagnosed Leber's Hereditary Optic Neuropathy with Clinical Signs of Idiopathic Intracranial Hypertension Responsive to Acetazolamide Therapy.

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):109-113

Department of Ophthalmology, Red Crescent Hospital, Dubai, UAE.

Purpose: To present a case of suspected Leber's hereditary optic neuropathy (LHON) with MRI and OCT findings compatible with pseudotumor cerebri responsive to acetazolamide therapy.

Case Report: A five-year-old boy referred to our clinic with optic atrophy and low vision was originally diagnosed with LHON. Laboratory tests were negative for LHON, while OCT and MRI were consistent with pseudotumor cerebri. Read More

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http://dx.doi.org/10.4103/jovr.jovr_85_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388523PMC
March 2019
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Idiopathic intracranial hypertension: Proposal of a stratification strategy for monitoring risk of disease progression.

Clin Neurol Neurosurg 2019 Apr 15;179:35-41. Epub 2019 Feb 15.

Neurosurgery Division, Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria; Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.

Objectives: A general consensus based on a multidisciplinary perspective involving an international panel was recently developed for management of patients with idiopathic intracranial hypertension (IIH). In this paper, the authors sought to develop further on the aspect of this consensus that concerns monitoring progression of the disease.

Patients And Methods: A systematic literature review of previous publications on monitoring disease progression in IIH and a meta-analysis to examine efficacy of method of monitoring employed in each study. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.013DOI Listing
April 2019
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Cerebrospinal Fluid Removal for Idiopathic Intracranial Hypertension: Less Cerebrospinal Fluid Is Best.

J Neuroophthalmol 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology (MDP), Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts; Jefferson Headache Center (SKP), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Neurology (FF-T), University of Puerto Rico School of Medicine, San Juan, Puerto Rico; UF Health Neurology Department (MTM), McKnight Brain Institute (L3-100), Gainesville, Florida; and Department of Neurology (MLR), Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Background: Although lumbar punctures (LPs) are used for diagnostic evaluation in idiopathic intracranial hypertension (IIH), they can also provide relief from IIH-associated headache. Conversely, low-pressure headache secondary to LP can be debilitating. Low-volume cerebrospinal fluid (CSF) removal to a "high-normal" closing pressure (CP), approximately 18-20 cm H2O, may result in relief of IIH-associated headache with a lowered frequency of post-LP headache. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000759DOI Listing
February 2019

Optic nerve ultrasonography to predict increased intracranial pressure in idiopathic intracranial hypertension.

Neuroradiol J 2019 Feb 22:1971400919832001. Epub 2019 Feb 22.

Department of Medicine, Surgery and Dentistry, University of Salerno, Italy.

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http://dx.doi.org/10.1177/1971400919832001DOI Listing
February 2019
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Accuracy and safety of B-scan optic nerve ultrasonography to predict increased intracranial pressure in idiopathic intracranial hypertension.

Neuroradiol J 2019 Feb 22:1971400919831463. Epub 2019 Feb 22.

Department of Neurology, Cairo University, Egypt.

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http://dx.doi.org/10.1177/1971400919831463DOI Listing
February 2019
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Chorioretinal folds: a proposed diagnostic algorithm.

Int Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Clinica Oculistica, DiNOGMI, Università degli Studi di Genova, Viale Benedetto XV 5, 16132, Genoa, Italy.

Purpose: To create a diagnostic algorithm for the management of chorioretinal folds.

Methods: We reviewed the existing literature about chorioretinal folds focusing our attention on three specific conditions and created a diagnostic algorithm in order to otpimize the choice and the number of investigations.

Results: Chorioretinal folds are visible striations of the fundus usually arranged in parallel lines and disposed horizontally. Read More

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http://dx.doi.org/10.1007/s10792-019-01083-yDOI Listing
February 2019

Differing presenting features of idiopathic intracranial hypertension in the UK and US.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Aim: Demographic factors potentially influencing the presentation and severity of idiopathic intracranial hypertension (IIH) in the US vs. UK populations include obesity and ethnicity. We aimed to compare the presenting features of IIH between populations in the UK and US tertiary referral centres, to assess what population differences exist and whether these cause different presentations and impact on visual function. Read More

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http://dx.doi.org/10.1038/s41433-019-0359-5DOI Listing
February 2019

Predictive role of presenting symptoms and clinical findings in idiopathic intracranial hypertension.

J Neurol Sci 2019 Apr 6;399:89-93. Epub 2019 Feb 6.

Danish Headache Center, Department of Neurology, University of Copenhagen, Rigshospitalet-Glostrup, Denmark.

Background: The aim of the study was to evaluate the presenting symptoms and signs of idiopathic intracranial hypertension (IIH) in a large cohort of patients and to estimate their possible role in establishing the diagnosis of IIH.

Methods: This prospective cohort study in two tertiary centers, the Danish Headache Center in Rigshospitalet-Glostrup and the Neurology Clinic of the Clinical Center of Serbia, included 286 patients referred by attending specialists for possible IIH evaluation. Patients were divided into two groups: one with confirmed IIH diagnosis and one with rejected IIH diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193006
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http://dx.doi.org/10.1016/j.jns.2019.02.006DOI Listing
April 2019
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[TREATMENT DILEMMAS IN FULMINANT INTRACRANIAL HYPERTENSION].

Harefuah 2019 Feb;158(2):96-100

Department of Ophthalmology, Barzilai University Medical Center, Israel.

Introduction: Fulminant intracranial hypertension is a rare, acute presentation of idiopathic intracranial hypertension with rapid and devastating visual loss that can lead to blindness. As vision deteriorates quickly and often irreversibly, prevention of further visual loss requires emergent treatment to decrease intracranial pressure. The case presented is that of an 18 years old male with new symptoms of headaches and visual obscurations that had rapid progressive visual loss with findings of severe bilateral swollen discs. Read More

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February 2019
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Headaches in Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2019 Mar;39(1):82-93

Departments of Neurology and Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Headache is the most common symptom of idiopathic intracranial hypertension (IIH) and may not resolve with intracranial pressure-lowering treatments. Many patients with IIH have a pre-existing history of migraine. Approximately two-thirds of patients with IIH continue to experience headaches after the other manifestations of the disorder resolve. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000777DOI Listing

Commentary: Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory Headache.

Front Neurol 2019 29;10:39. Epub 2019 Jan 29.

Division of Neurology and Stroke Unit, Hospital A. Cardarelli, Naples, Italy.

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http://dx.doi.org/10.3389/fneur.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361781PMC
January 2019
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