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Indian J Dermatol 2021 Jan-Feb;66(1):74-80

Department of Dermatology, All India Institute of Medical Sciences, Patna, Bihar, India.

Background: Elderly population is vulnerable to develop a multitude of dermatological diseases, owing to comorbidities and polypharmacies.

Objective: To know the prevalence of dermatological conditions in elderly patients attending outpatient department, determine the pattern and relative frequency of skin diseases, and find the relation with associated comorbidities.

Materials And Methods: We performed a cross-sectional study on 250 patients, aged ≥60 years. Read More

J Cosmet Dermatol 2021 Apr 24. Epub 2021 Apr 24.

Department of Skin & V.D, Nalanda Medical College and Hospital, Patna, India.

Background: Oxidative stress parameters have been reported to be significantly higher than controls in diverse disorders of pigmentation but no such data seem to be extant for IGH.

Objectives: To verify whether heightened oxidative stress levels are seen in patients with IGH (compared with matched controls) and quantify the same in blood using appropriate biochemical markers. Further, an attempt to determine if there might be any correlation between the amount of oxidative stress and the severity of the disease. Read More

Dermatol Surg 2021 Feb 8. Epub 2021 Feb 8.

Birmingham Medical School, University of Birmingham, Birmingham, United Kingdom; Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark; Vernova Healthcare CIC, Macclesfield, United Kingdom; Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: 5-fluorouracil (5-FU) is widely used for treatment of malignant and premalignant skin cancers; however, its use in other common cutaneous conditions has been less widely reported.

Objective: We investigated the off-label uses of 5-FU beyond malignant and premalignant skin disease.

Methods: We conducted a literature review searching multiple databases to evaluate the evidence for the off-label uses of 5-FU. Read More

Hautarzt 2020 Dec;71(12):932-943

Carol-Davila-Universität für Medizin und Pharmazie, Bukarest, Rumänien.

Pigmentation disorders are a frequent skin problem and incorporate a broad spectrum of diseases, caused by an abnormal melanin pigmentation or also non-melanin pigmentation of the skin. Both hypermelanosis and hypomelanosis can be hereditary or acquired. This article summarizes the treatment approaches that are used in the majority of acquired pigmentation disorders of the skin. Read More

Niger J Clin Pract 2020 Jul;23(7):970-974

Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Background: Diabetes mellitus is one of the most common metabolic disorders with a rising prevalence. It cuts across all ages and socioeconomic status. Various skin lesions are frequently observed in diabetic patients. Read More

J Am Acad Dermatol 2020 Apr 28. Epub 2020 Apr 28.

Br J Dermatol 2020 06 14;182(6):1481-1482. Epub 2020 Jan 14.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Br J Dermatol 2020 02 6;182(2):485-486. Epub 2019 Oct 6.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Dermatol Reports 2019 Jan 21;11(1):7916. Epub 2018 Dec 21.

Faculty of Medicine, Mutah University, Jordan.

One of the most frequent complaints in dermatology clinics is the eruption of hypopigmented patchy skin lesions. The aim of the study was to investigate the utility of dermoscopy in common hypopigmented macular diseases. Patients with the followings diseases were examined by dermoscopy: vitiligo, pityriasis alba, nevus depigmentosus, achromic pityriasis versicolor, idiopathic guttate hypomelanosis, and extragenital guttate lichen sclerosus. Read More

Skin Appendage Disord 2019 Feb 14;5(2):100-103. Epub 2018 Jun 14.

Department of Dermatology and Cutaneous Surgery University of Miami L. Miller School of Medicine, University of Miami L. Miller School of Medicine, Miami, Florida, USA.

Frontal fibrosing alopecia (FFA) is characterized by progressive band-like scarring alopecia involving the frontotemporal hairline and limbs and irreversible alopecia of the eyebrows. Two opposite types of pigmentary alterations have been reported in FFA: hyper- and hypopigmentation. Here, we report a 57-year-old Hispanic female with FFA who presented with peripilar hypopigmentation and idiopathic guttate hypomelanosis on the upper extremities. Read More

J Am Acad Dermatol 2019 May 17;80(5):1233-1250.e10. Epub 2018 Sep 17.

Department of Dermatology, University of Florida, Gainesville, Florida; Department of Pediatrics, University of Florida, Gainesville, Florida.

Acquired hypopigmented skin changes are commonly encountered by dermatologists. Although hypopigmentation is often asymptomatic and benign, occasional serious and disabling conditions present with cutaneous hypopigmentation. A thorough history and physical examination, centered on disease distribution and morphologic findings, can aid in delineating the causes of acquired hypopigmented disorders. Read More

Mol Genet Genomics 2018 Dec 20;293(6):1469-1475. Epub 2018 Jul 20.

Mckusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Acne inversa (AI) is a chronic inflammatory disease of hair follicles. The pathogenesis of AI remains unclear. Haploinsufficiency of genes encoding γ-secretase components is the genetic basis for a subset of familial AI. Read More

Pediatr Dermatol 2018 Sep 26;35(5):639-643. Epub 2018 Jun 26.

Departments of Dermatology, Venereology, and STDs, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Background: Cutaneous manifestations can be found in many patients with hematologic disorders, including thalassemia.

Methods: Patients with beta-thalassemia major attending the pediatric department of Fayoum University Hospital from April 2016 to October 2016 (n = 100) were compared with controls (n = 100). Both groups underwent detailed history evaluation, clinical examination, and laboratory investigations, including complete blood count, liver and kidney function, serum ferritin, and thyroid profile. Read More

J Am Acad Dermatol 2018 10 2;79(4):e79. Epub 2018 Jun 2.

Department of Medicine, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address:

J Am Acad Dermatol 2018 10 2;79(4):e81-e82. Epub 2018 Jun 2.

Department of Dermatology, São Paulo State School of Medicine, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil.

JAAD Case Rep 2018 Apr 6;4(3):262-266. Epub 2018 Mar 6.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

J Cosmet Laser Ther 2018 Nov - Dec;20(7-8):405-409. Epub 2018 Mar 16.

a Department of Dermatology , Hanyang University College of Medicine , Seoul , Korea.

: Despite various treatments attempts, no prospective studies have compared the different therapeutic modalities for treatment of idiopathic guttate hypomelanosis (IGH). This study aimed to compare the efficacy of CO fractional laser (CO₂FL), Er:YAG fractional laser (EYFL), and 0.025% topical tretinoin for treating IGH. Read More

Int J Dermatol 2018 May 8;57(5):559-565. Epub 2018 Mar 8.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Idiopathic guttate hypomelanosis (IGH) is a pigmentary disorder of unknown pathogenesis characterized by small discrete white macules. In the skin, epidermal melanin unit between melanocytes and keratinocytes is responsible for melanin synthesis and equal distribution of melanin pigment.

Objective: Therefore, this study was designed to check the role of melanocytes in the pathogenesis of IGH. Read More

J Am Acad Dermatol 2018 01;78(1):212-215

Department of Dermatology, São Paulo State School of Medicine, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil.

J Am Acad Dermatol 2018 04 2;78(4):e81-e82. Epub 2017 Nov 2.

Private Practice, Herzlia Pituach, Israel.

Dermatol Surg 2017 Apr;43(4):553-557

*Westlake Dermatology, Austin, Texas; †Department of Medicine (Dermatology), Dell Medical School, University of Texas at Austin, Austin, Texas.

Background: Idiopathic guttate hypomelanosis (IGH) is a commonly acquired benign leukoderma characterized by multiple discrete, hypo- or depigmented macules often on extremities that can be aesthetically undesirable for patients. This is the first study using excimer laser for treatment.

Objective: To determine the effectiveness of excimer laser for repigmentation of idiopathic guttate hypomelanosis. Read More

Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):205-211

Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.

Background: There are few population-based studies on prevalence of cutaneous problems in diabetes mellitus.

Aims: To identify skin problems associated with diabetes mellitus among elderly persons in a village in Kerala.

Methods: In this population-based cross-sectional survey, we compared the prevalence of skin problems among 287 elderly diabetics (aged 65 years or more) with 275 randomly selected elderly persons without diabetes mellitus. Read More

Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

J Dermatolog Treat 2017 May 23;28(3):271-275. Epub 2016 Aug 23.

a Division of Dermatology, Chulabhorn International College of Medicine , Thammasat University , Pathum Thani , Thailand.

Background: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine its efficacy. Read More

Am J Clin Dermatol 2016 Aug;17(4):403-11

Department of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.

Idiopathic guttate hypomelanosis is a common acquired leukoderma characterized by multiple, discrete round or oval, porcelain-white macules on sun-exposed areas, especially on the extensor surface of forearms and pretibial areas. It usually affects individuals aged over 40 years and the likelihood of acquiring it increases with age. The exact pathogenesis remains controversial. Read More

J Dermatolog Treat 2016 Oct 10;27(5):456-60. Epub 2016 Feb 10.

a Division of Dermatology , Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bangkok , Thailand and.

Background: The efficacy of fractional photothermolysis and topical use of calcineurin inhibitors as treatments of idiopathic guttate hypomelanosis (IGH) have been reported. Data on combination treatments are lacking.

Objectives: To evaluate the efficacy and safety of 1550-nm ytterbium/erbium fiber laser combined with 0. Read More

Cutis 2015 Sep;96(3):156,184-5

PO Box 8000, Northern Blvd, Old Westbury, NY 11568, USA.

J Dermatol 2015 Nov 27;42(11):1118-9. Epub 2015 Jul 27.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Indian Dermatol Online J 2015 May-Jun;6(3):164-7

Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Background: Depigmented skin lesions are of great concern in the society, especially in the Indian subcontinent. These comprise many infective and inflammatory conditions that cause apprehension and anxiety among patients due to the social stigma attached to these conditions. Idiopathic guttate hypomelanosis (IGH) appears similar to many depigmented lesions and differentiation of IGH from these conditions is difficult clinically as well as histopathologically. Read More