34,779 results match your criteria Id Reaction Autoeczematization


Does exclusive breastfeeding relate to the longer duration of breastfeeding? A prospective cohort study.

Midwifery 2018 Nov 19;69:163-171. Epub 2018 Nov 19.

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Suboptimal breastfeeding contributes to morbidity and mortality in children. Studies in high-income countries (HICs) show that exclusive-breastfeeding (EBF) is associated with longer breastfeeding duration. The aim of this study was to determine whether maternal reports of EBF at six months are associated with longer duration of breastfeeding during the first two years of life in a low and middle-income country (LMIC) setting, and to identify determinants of breastfeeding duration. Read More

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November 2018

Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3): A Randomized Controlled Trial.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Case Western Reserve University, Cleveland, Ohio, United States.

Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More

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December 2018

MER: a shell script and annotation server for minimal named entity recognition and linking.

J Cheminform 2018 Dec 5;10(1):58. Epub 2018 Dec 5.

LASIGE, Faculdade de Ciências, Universidade de Lisboa, 1749 016, Lisbon, Portugal.

Named-entity recognition aims at identifying the fragments of text that mention entities of interest, that afterwards could be linked to a knowledge base where those entities are described. This manuscript presents our minimal named-entity recognition and linking tool (MER), designed with flexibility, autonomy and efficiency in mind. To annotate a given text, MER only requires: (1) a lexicon (text file) with the list of terms representing the entities of interest; (2) optionally a tab-separated values file with a link for each term; (3) and a Unix shell. Read More

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December 2018

rs3834129 (-652 6N insertion/deletion) Polymorphism and Colorectal Cancer Susceptibility: An Updated Meta-Analysis.

J Cancer 2018 18;9(22):4166-4171. Epub 2018 Oct 18.

Department of Pathology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

rs3834129 polymorphism (-652 6N insertion/deletion) is a genetic alteration which might affect the apoptosis pathway caspase enzyme. The impaired caspase enzyme would lead to the change of cancer risk. By now, the role of rs3834129 polymorphism has been widely investigated. Read More

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October 2018

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

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October 2018
1 Read

Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients: the ESPRIT Study.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

The optimal level of sodium intake remains controversial, and the effects on a broad range of cardiovascular (CV) conditions remain unknown. The Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients (ESPRIT) is a prospective observational study designed to investigate whether sodium intake assessed by spot urine testing is associated with adverse CV events. A total of 520 patients who visited our cardiology clinic with various cardiovascular risk profiles were included. Read More

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December 2018

Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.

Arthritis Res Ther 2018 Dec 5;20(1):268. Epub 2018 Dec 5.

Rheumatology and Immunology Center, China Medical University Hospital, No. 2, Yude Road, Taichung, 40447, Taiwan.

Background: Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving biologic therapy.

Methods: In 72 patients with RA and 20 healthy control subjects (HC), autophagosome levels were determined by the mean fluorescence intensity (MFI) of autophagosomotropic dye incorporated into circulating immune cells, and p62 expression levels in immune cells were measured by flow cytometry. Read More

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December 2018
1 Read

Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study.

BMC Cardiovasc Disord 2018 Dec 5;18(1):224. Epub 2018 Dec 5.

Department of Cardiology, Nihon University Hospital, 1-6 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.

Background: Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have demonstrated that higher LCAT activity, measured in terms of the serum cholesterol esterification rate by an endogenous substrate method, is associated with increased formation of triglyceride (TG)-rich lipoproteins (TRLs), leading to a decrease in the low-density lipoprotein (LDL) particle size. The purpose of this hospital-based longitudinal study was to clarify the causal relationship between changes in the LCAT activity and changes in the LDL-particle size. Read More

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December 2018

Oral fosfomycin versus ciprofloxacin in women with E.coli febrile urinary tract infection, a double-blind placebo-controlled randomized controlled non-inferiority trial (FORECAST).

BMC Infect Dis 2018 Dec 5;18(1):626. Epub 2018 Dec 5.

University Medical Centre Utrecht, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.

Background: Febrile Urinary Tract Infection (FUTI) is frequently treated initially with intravenous antibiotics, followed by oral antibiotics guided by clinical response and bacterial susceptibility patterns. Due to increasing infection rates with multiresistant Enterobacteriaceae, antibiotic options for stepdown treatment decline and patients more frequently require continued intravenous antibiotic treatment for FUTI. Fosfomycin is an antibiotic with high bactericidal activity against Escherichia coli and current resistance rates are low in most countries. Read More

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December 2018

Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service.

BMC Infect Dis 2018 Dec 5;18(1):627. Epub 2018 Dec 5.

AIDS Clinical Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Men who have sex with men (MSM) are at high risk of HIV infection. However, there are only few data on HIV prevalence in MSM in Japan. The objective of this study was to explore the HIV prevalence in MSM at Shinjuku 2-chome, a well known gay quarter in Tokyo. Read More

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December 2018

A Chemoproteomic Strategy for Direct and Proteome-wide Covalent Inhibitor Target-site Identification.

J Am Chem Soc 2018 Dec 6. Epub 2018 Dec 6.

Despite recent clinical successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off-target cysteines represents a major hurdle for expansion of covalent drug programs. Understanding the proteome-wide binding profile of covalent inhibitors can significantly accelerate their development; however, current mass spectrometry strategies typically do not provide a direct, amino acid level readout of covalent activity for complex, selective inhibitors. Here we report the development of CITe-Id, a novel chemoproteomic approach that employs covalent pharmacologic inhibitors as enrichment reagents in combination with an optimized proteomic platform to directly quantify dose-dependent binding at cysteine-thiols across the proteome. Read More

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December 2018

Population Genomic Analysis of North American Eastern Wolves (Canis lycaon) Supports Their Conservation Priority Status.

Genes (Basel) 2018 Dec 4;9(12). Epub 2018 Dec 4.

Department of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.

The threatened eastern wolf is found predominantly in protected areas of central Ontario and has an evolutionary history obscured by interbreeding with coyotes and gray wolves, which challenges its conservation status and subsequent management. Here, we used a population genomics approach to uncover spatial patterns of variation in 281 canids in central Ontario and the Great Lakes region. This represents the first genome-wide single nucleotide polymorphism (SNP) dataset with substantial sample sizes of representative populations. Read More

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December 2018
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The Effectiveness of Nutrition Education for Overweight/Obese Mother with Stunted Children (NEO-MOM) in Reducing the Double Burden of Malnutrition.

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS 66506, USA.

(1) Background: In households experiencing the double burden of malnutrition, stunted children are in a better position for growth improvement when parents are able to direct their resources to support nutrition requirements. This study assesses the effectiveness of maternal nutrition education to reduce child stunting. (2) Methods: This was a Randomized Controlled Trial involving pairs of overweight/obese mothers with stunted children aged 2 to 5 years old in urban Indonesia. Read More

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December 2018

Current Use of Technology in Athletic Training Education.

J Allied Health 2018 ;47(4):272-276

Idaho State University, 921 S. 8th Avenue, Stop 8105, Pocatello, ID 83209-8105, USA. Tel 208-282-4441, fax 208-282-4654.

Technology education in higher education and the health care professions is found throughout the literature. Athletic training education (ATE) should mirror that of other health care professions. The purpose of this study was exploratory in nature to determine a) how ATE faculty are integrating technology into their classrooms, b) which they find to be most effective and why, and c) which technologies they hope to use in the future. Read More

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January 2018

Synthesis of novel gallium-68 labeled rhodamine: A potential PET myocardial perfusion agent.

Appl Radiat Isot 2018 Sep 8;144:29-33. Epub 2018 Sep 8.

Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine studies. Due to the physical properties of the positron emitter gallium-68 (Ga) and its availability from Ge/Ga generator, together with the well-known coordination chemistry, we have synthesized Ga-NOTA- and Ga-NODAGA-rhodamine conjugates using a straightforward and a one-step simple reaction. Radiochemical yields were greater than 95% (decay corrected), with total synthesis time of less than 30 min. Read More

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September 2018

Epidemiology and microbiology of skin and soft tissue infections: preliminary results of a National registry.

J Chemother 2018 Dec 3:1-6. Epub 2018 Dec 3.

y UOC Medicina Interna , Ospedale Umberto I , Enna , Italy.

Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by a considerable variety of clinical presentations and severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types of SSTI and on restricted types of patients, we conducted a large nationwide surveillance programme on behalf of the Italian Society of Infectious and Tropical Diseases to assess the clinical and microbiological characteristics of the whole SSTI spectrum, from mild to severe life-threatening infections, in both inpatients and outpatients. Read More

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December 2018
1 Read

Attitude and willingness of pediatric dentists regarding dental care for children with developmental and intellectual disabilities.

Spec Care Dentist 2018 Dec 3. Epub 2018 Dec 3.

NYC Health + Hospitals | Jacobi, Pediatric Dentistry, Bronx, New York.

Aim: Children with developmental and/or intellectual disabilities (DD/ID) are considered to be at greater risk of developing dental disease and are more likely to have unmet dental needs than other children. The purpose of this study was to determine the attitude and willingness of pediatric dentists and residents to provide dental care for children with DD/ID.

Methods: Two surveys were created and emailed via SurveyMonkey to pediatric dentists and post-doctoral student members of the American Academy of Pediatric Dentistry. Read More

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December 2018

Insulin and incretin responses to grazing in insulin-dysregulated and healthy ponies.

J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.

Department of Bioscience, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: Supraphysiological insulin and incretin responses to a cereal-based diet have been described in horses and ponies with insulin dysregulation (ID). However, the hormonal responses to grazing have not yet been described.

Objectives: To determine if there is a difference in the insulin and incretin responses to grazing pasture between insulin-dysregulated and healthy ponies. Read More

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December 2018

Prevalence and Types of School-Based Out-of-School Time Programs at Elementary Schools and Implications for Student Nutrition and Physical Activity.

J Sch Health 2019 Jan;89(1):48-58

College of Education, Boise State University, 1910 University Drive, #1740, Boise, ID 83725-1740.

Background: Out-of-school time (OST) programs are an important setting for supporting student health and academic achievement. This study describes the prevalence and characteristics of school-based OST programs, which can inform efforts to promote healthy behaviors in this setting.

Methods: A nationally representative sample of public elementary schools (N = 640) completed surveys in 2013-2014. Read More

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January 2019

Fumaric acid: production and separation.

Biotechnol Lett 2018 Dec 1. Epub 2018 Dec 1.

Faculty of Chemical Engineering and Environmental Protection "Cristofor Simionescu", "Gheorghe Asachi" Technical University of Iaşi, Iasi, Romania.

Fumaric acid is a valuable compound used in foods, beverages, detergents, animal feed, pharmaceuticals and miscellaneous industrial products. It is produced on a large scale by the petrochemical route but the current tendency is towards implementing "green production" and environmental friendly technologies like biotechnological production of fumaric acid using low-cost raw materials. In this context, numerous studies focus on improving the fermentation process not only by using renewable raw material and genetically modified microorganisms, but also by developing and applying different downstream techniques for easy recovery of fumaric acid from the fermented broth. Read More

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December 2018
1 Read

Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics.

Data Brief 2018 Dec 31;21:1750-1755. Epub 2018 Aug 31.

Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong.

Myopia is generally regarded as a failure of normal emmetropization process, however, its underlying molecular mechanisms are unclear. Retinal protein profile changes using integrated SWATH and MRM-HR MS were studied in guinea pigs at 3- and 21-days of age, where the axial elongation was significantly detected. Differential proteins expressions were identified, and related to pathways which are important in postnatal development in retina, proliferation, breakdown of glycogen-energy and visual phototransduction. Read More

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December 2018

An integrated dataset for stakeholder perceptions of environmental change and instrumented measures of change.

Data Brief 2018 Dec 27;21:1721-1723. Epub 2018 Oct 27.

United States Fish & Wildlife Service, Anchorage Fish and Wildlife Conservation Office, 4700 BLM Road, Anchorage, AK 99507, USA.

An integrated dataset was developed that combined stakeholder perceptions of environmental change (precipitation, air temperature, water temperature, fish abundance, fish size, residential development) and comparable instrumented measures of environmental changes based on sensor records. All data were transformed to a common 3-point categorical scale to support statistical comparison of social and biophysical change for the same change variables. The integrated dataset is available on Mendeley (http://dx. Read More

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December 2018

Arthroscopic Superior Capsular Reconstruction With a Minimally Invasive Harvested Fascia Lata Autograft Produces Good Clinical Results.

Orthop J Sports Med 2018 Nov 27;6(11):2325967118808242. Epub 2018 Nov 27.

Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento, Lisbon, Portugal.

Background: Painful dysfunctional shoulders with irreparable rotator cuff tears (IRCTs) in active patients are a challenge. Arthroscopic superior capsular reconstruction (ASCR) is a new treatment option originally described using a fascia lata autograft harvested through an open approach. However, concerns about donor site morbidity have discouraged surgeons from using this type of graft. Read More

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November 2018

Tat-functionalized Ag-FeO nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery.

Acta Pharm Sin B 2018 Oct 6;8(6):956-968. Epub 2018 Aug 6.

State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide (Tat), producing Tat-modified Ag-FeO nanocomposites (Tat-FeAgNPs). To load drugs, an -SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin (Dox) in a pH-sensitive pattern. Read More

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October 2018

AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel.

Anticancer Res 2018 Dec;38(12):6699-6706

Department of Molecular Cancer Science, Yamagata University School of Medicine, Yamagata, Japan

Background: AS602801, a novel inhibitor of c-Jun N-terminal kinase (JNK), suppresses tumor initiation capacity and metastatic potential of cancer stem cells (CSCs). However, it remains unknown whether this inhibitor can chemosensitize CSCs.

Materials And Methods: Using A2780 CSLC, a CSC line derived from ovarian cancer, this study examined the combinational effects of AS602801 and carboplatin or paclitaxel and explored the mechanism of those effects. Read More

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December 2018

Computational characterization and molecular dynamics simulation of the thermostable direct hemolysin-related hemolysin (TRH) amplified from Vibrio parahaemolyticus.

Microb Pathog 2018 Nov 29;127:172-182. Epub 2018 Nov 29.

Biotechnology Laboratory, ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata, 700120, West Bengal, India.

Vibrio parahaemolyticus is a major seafood-borne pathogen that causes life-threatening gastroenteric diseases in humans through the consumption of contaminated seafoods. V. parahaemolyticus produces different kinds of toxins, including thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), and some effector proteins belonging to the Type 3 Secretion System, out of which TDH and TRH are considered to be the major factors for virulence. Read More

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November 2018

Identification of a novel SIRT7 inhibitor as anticancer drug candidate.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Division of Innovative Target Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, South Korea. Electronic address:

Sirtuins (SIRT1-7), a class of deacetylases, play major roles in DNA damage repair, aging, and metabolism in yeast and in mammals. SIRT7 is localized in the nucleolus. It regulates cellular processes, including genomic stability, rDNA transcription, and cell proliferation, and plays a role in tumorigenesis. Read More

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November 2018
3 Reads

Underwater noise from airplanes: An overlooked source of ocean noise.

Mar Pollut Bull 2018 Dec 14;137:656-661. Epub 2018 Nov 14.

Bali Program Manager, Conservation International Indonesia, Bali 80235, Indonesia. Electronic address:

The effects of underwater noise pollution on marine life are of increasing concern. Research and management have focussed on the strongest underwater sound sources. Aerial sound sources have understandably been ignored as sound transmits poorly across the air-water interface. Read More

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December 2018

Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test.

Semin Hematol 2018 Oct 7;55(4):256-261. Epub 2018 Aug 7.

Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria; Loha for life, Center of Excellence for Iron Deficiency, Vienna, Austria. Electronic address:

Iron deficiency (ID) workup is a common challenge for gastrointestinal endoscopy. In premenopausal women current guidelines recommend serologic evaluation of coeliac disease only. Here we systematically tested serologic screening for autoimmune gastritis (AIG) in a large cohort of patients with ID. Read More

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October 2018
1 Read

Important Group Differences on the Functional Assessment of Cancer Therapy-Kidney Symptom Index Disease-Related Symptoms in Patients with Metastatic Renal Cell Carcinoma.

Value Health 2018 Dec 11;21(12):1413-1418. Epub 2018 May 11.

Pfizer Inc., Groton, CT, USA.

Background: The Functional Assessment of Cancer Therapy-Kidney Symptom Index Disease-Related Symptoms (FKSI-DRS) is important to gauge clinical benefit in metastatic renal cell carcinoma (mRCC).

Objectives: To estimate important difference (ID) in FKSI-DRS scores that is considered to be meaningful when comparing treatment effect between groups, using mRCC trial data.

Methods: Data were derived from two pivotal phase III mRCC trials comparing sunitinib versus interferon alfa (N = 750) in first-line mRCC, and axitinib versus sorafenib (N = 723) in second-line mRCC. Read More

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December 2018

Investigation of graded-level soybean meal diets in red drum (Sciaenops ocellatus) using NMR-based metabolomics analysis.

Comp Biochem Physiol Part D Genomics Proteomics 2018 Nov 16;29:173-184. Epub 2018 Nov 16.

Marine Biochemical Sciences Group, Chemical Sciences Division, National Institute of Standards and Technology, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, USA; Ichthus Unlimited, LLC, 109, S. 32nd Street, West Des Moines, IA, 50265.

We investigated changes in the metabolome in juvenile red drum (Sciaenops ocellatus) induced by increasing amounts of soybean meal (0% to 60%) in extruded, fishmeal-free diets using a nuclear magnetic resonance spectroscopy (NMR)-based metabolomics approach in a 12-week feeding trial. All of the diets were composed of ≈40% total crude protein, ≈11% total crude lipid and were energetically balanced. A fishmeal-containing, commercial extruded diet was used as a control diet throughout the trial. Read More

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November 2018

Combined Genetic Effects of RET and NRG1 Susceptibility Variants on Multifactorial Hirschsprung Disease in Indonesia.

J Surg Res 2019 Jan 17;233:96-99. Epub 2018 Aug 17.

Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas.

Background: Specific genetic variants at RET (rs2435357) and NRG1 (rs7835688, rs16879552) are associated with Hirschsprung disease (HSCR) in Indonesia. This study aimed to investigate the additional effect of RET rs2506030 on these variants to determine its potential interactions in HSCR patients of Indonesian ancestry.

Methods: Sixty HSCR patients and 122 non-HSCR controls were ascertained for this study and genotyped for RET rs2506030 using the TaqMan assay. Read More

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January 2019

Electromagnetic waves' effect on airflow during air sparging.

J Contam Hydrol 2018 Nov 14. Epub 2018 Nov 14.

Professor, Department of Electrical & Computer Engineering, Boise State University, 1910 University Dr., MS 2075, Boise, ID 83725-2075, USA.

Air sparging is a popular, yet slow, remediation technology for soil and groundwater contaminated with volatile organic compounds (VOCs). This paper theoretically and experimentally studies the effect of electromagnetic (EM) waves on air-channel formation within a glass-bead medium-used as an analogy to soil-during air-sparging experiments. The impact of EM waves on cleanup is not the focus of this paper, and the impact on airflow may or may not positively impact resulting cleanup process using air sparging to remove VOCs through volatilization. Read More

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November 2018

Investigation of Carbon Coated LiFePO₄ as a Superior Cathode Material for Lithium Ion Batteries.

J Nanosci Nanotechnol 2019 May;19(5):3002-3011

Centre for Nanomaterials, International Advanced Research Centre for Powder Metallurgy and New Materials, Hyderabad 500005, India.

In the present study, we have developed a simple and cost-effective approach for the synthesis of carbon coated LiFePO₄ wherein different carbon precursors were used to find out the suitable precursor for carbon coating. Initially, the appropriate amount of Li, Fe, and P precursors and carbon source (glucose/sucrose/fructose) were dissolved in ethanol solution followed by hydrothermal treatment at 180 °C to obtain carbon coated LiFePO₄. The structure and morphological analysis of carbon coated LiFePO₄ revealed the formation of thin and homogeneous carbon layer on crystalline single-phase LiFePO₄ particles with fructose used as carbon precursor. Read More

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Monomyristin and Monopalmitin Derivatives: Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents.

Molecules 2018 Nov 29;23(12). Epub 2018 Nov 29.

Faculty of Pharmacy, University of Jember, Jember 68121, Indonesia.

In the present work, monoacylglycerol derivatives, i.e., 1-monomyristin, 2-monomyristin, and 2-monopalmitin were successfully prepared from commercially available myristic acid and palmitic acid. Read More

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November 2018

Pharmacy Technician-Administered Vaccines: On Perceptions and Practice Reality.

Pharmacy (Basel) 2018 Nov 29;6(4). Epub 2018 Nov 29.

Center for Pharmacy Practice Research, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99210, USA.

Doucette and Schommer recently surveyed U.S. community pharmacy technicians on their willingness to perform tasks including the administration of vaccines. Read More

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November 2018

π-π stacking interaction is a key factor for the stability of GH11 xylanases at low pH.

Int J Biol Macromol 2018 Dec 2;124:895-902. Epub 2018 Dec 2.

Department of Biotechnology and Bioengineering, Huaqiao University, Xiamen 361021, Fujian, PR China. Electronic address:

Acidic xylanases possess the unique features necessary for the tolerance of acidic environments, which may have great potentials for industrial purposes. However, factors controlling the pH-dependent stability of xylanases are only partially known. Here we proposed a residue interaction networks based method to analyze the differences of residue interactions between 6 pairs of experimentally verified acidic and neutral xylanases. Read More

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December 2018
1 Read

Chiral Spin Density Wave and d+id Superconductivity in the Magic-Angle-Twisted Bilayer Graphene.

Phys Rev Lett 2018 Nov;121(21):217001

School of Physics, Beijing Institute of Technology, Beijing 100081, China.

We model the newly synthesized magic-angle-twisted bilayer graphene superconductor with two p_{x,y}-like Wannier orbitals on the superstructure honeycomb lattice, where the hopping integrals are constructed via the Slater-Koster formulism by symmetry analysis. The characteristics exhibited in this simple model are well consistent with both the rigorous calculations and experiment observations. A van Hove singularity and Fermi-surface (FS) nesting are found in the doping levels relevant to the correlated insulator and unconventional superconductivity revealed experimentally, based on which we identify the two phases as weak-coupling FS instabilities. Read More

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November 2018

Protein Intake and Risk of Falls: A Prospective Analysis in Older Adults.

J Am Geriatr Soc 2018 Dec 5. Epub 2018 Dec 5.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-IdiPaz, Madrid, Spain.

Background: The prospective association between protein intake and falls has been little studied. We assessed this association in a Spanish community-dwelling cohort.

Methods: We performed a prospective cohort study of 2464 men and women 60 years or older who were recruited in 2008-2010 and followed up through 2012. Read More

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December 2018
1 Read

Golden Orbweavers Ignore Biological Rules: Phylogenomic and Comparative Analyses Unravel a Complex Evolution of Sexual Size Dimorphism.

Syst Biol 2018 Dec 4. Epub 2018 Dec 4.

Department of Entomology and Nematology, University of California Davis, 1 Shields Drive, Davis, CA, USA.

Instances of sexual size dimorphism (SSD) provide the context for rigorous tests of biological rules of size evolution, such as Cope's Rule (phyletic size increase), Rensch's Rule (allometric patterns of male and female size), as well as male and female body size optima. In certain spider groups, such as the golden orbweavers (Nephilidae), extreme female-biased SSD (eSSD, female:male body length ≥ 2) is the norm. Nephilid genera construct webs of exaggerated proportions, which can be aerial, arboricolous, or intermediate (hybrid). Read More

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December 2018

Idea density in Japanese for the early detection of dementia based on narrative speech.

PLoS One 2018 5;13(12):e0208418. Epub 2018 Dec 5.

Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma City, 630-0192, Japan.

Background: Idea density (ID), a natural language processing-based index, was developed to aid in the detection of dementia through the analysis of English narratives. However, it has not been applied to non-English languages due to the difficulties in translating grammatical concepts. In this study, we defined rules to count ideas in Japanese narratives based on a previous study and proposed a novel method to estimate ID in Japanese text using machine translation. Read More

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December 2018
1 Read

Promoting the Delivery of Nanoparticles to Atherosclerotic Plaques by DNA Coating.

ACS Appl Mater Interfaces 2018 Dec 5. Epub 2018 Dec 5.

School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai , China.

Many nanoparticle-based carriers to atherosclerotic plaques contain peptides, lipoproteins, and sugars, yet the application of DNA-based nanostructures for targeting plaques remains infrequent. In this work, we demonstrate that DNA-coated superparamagnetic iron oxide nanoparticles (DNA-SPIONs), prepared by attaching DNA oligonucleotides to poly(ethylene glycol)-coated SPIONs (PEG-SPIONs), effectively accumulate in the macrophages of atherosclerotic plaques following an intravenous injection into apolipoprotein E knockout (ApoE) mice. DNA-SPIONs enter RAW 264. Read More

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December 2018
5 Reads

Development of the Leiden Independence Questionnaire for Support Staff: a measure of staff behaviour regarding promoting independence of people with intellectual disabilities.

J Intellect Disabil Res 2018 Dec 5. Epub 2018 Dec 5.

Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands.

Background: Support staff of adults with intellectual disability (ID) play an important role in promoting independence in home and community settings. However, little is known about the types of behaviours staff should use to promote independence and instruments that assess such behaviour do not yet exist. The aim of this study was therefore to develop and initially validate a reliable questionnaire that measures the degree to which support staff display behaviours that promote independence in people with ID. Read More

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December 2018

The predictive value of malnutrition for functional and cognitive status in elderly hemodialysis patients.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Univeristy Street Nr. 16, 700115, Iasi, Romania.

Objective: The study aims to objectively and precisely describe, in elderly dialysis patients from a single center, the prevalence of malnutrition and severe cognitive/functional impairment and to establish the prognostic role of malnutrition assessment for patient's severe cognitive/functional status.

Design: Cross-sectional study.

Setting: A single dialysis center from north-eastern Romania. Read More

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December 2018
1 Read

Human Factors Affecting Logging Injury Incidents in Idaho and the Potential for Real-Time Location-Sharing Technology to Improve Safety.

Safety (Basel) 2018 Oct;4(4):43

Department of Forest, Rangeland and Fire Sciences, College of Natural Resources, University of Idaho, Moscow, ID 83844, USA; (R.F.K.); (R.H.B.); (A.M.W.).

Human factors, including inadequate situational awareness, can contribute to fatal and near-fatal traumatic injuries in logging, which is among the most dangerous occupations in the United States. Real-time location-sharing technology may help improve situational awareness for loggers. We surveyed and interviewed professional logging contractors in Idaho to (1) characterize current perceptions of in-woods hazards and the human factors that lead to injuries; (2) understand their perspectives on using technology-based location-sharing solutions to improve safety in remote work environments; and (3) identify logging hazard scenarios that could be mitigated using location-sharing technology. Read More

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October 2018
3 Reads

Association Between - 675 ID, 4G/5G PAI-1 Gene Polymorphism and Pregnancy Loss: A Systematic Review.

Acta Inform Med 2018 Oct;26(3):156-159

International Burch University, Bosnia and Herzegovina.

Introduction: Several analysis for different population conclude that endothelial plasminogen activator inhibitor 1 gene polymorphism, -675 ID, 4G/5G (ref SNP ID: rs1799889, also described as rs34857375, has merged into rs1799762) may increase risk of pregnancy loss (PL). However, there is a disagreement as to the association 4G allele with pregnancy loss.

Aim: Therefore, we decided to investigate the -675 ID, 4G/5G as a potential genetic factor linked to PL in European and worldwide populations. Read More

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October 2018

A multicenter, randomized controlled comparison of three renutrition strategies for the management of moderate acute malnutrition among children aged from 6 to 24 months (the MALINEA project).

Trials 2018 Dec 4;19(1):666. Epub 2018 Dec 4.

Department of Parasites and Vector Insects, Institut Pasteur, 28 Rue du Dr. Roux, 75015, Paris, France.

Background: The aim of this open-label, randomized controlled trial conducted in four African countries (Madagascar, Niger, Central African Republic, and Senegal) is to compare three strategies of renutrition for moderate acute malnutrition (MAM) in children based on modulation of the gut microbiota with enriched flours alone, enriched flours with prebiotics or enriched flours coupled with antibiotic treatment.

Methods: To be included, children aged between 6 months and 2 years are preselected based on mid-upper-arm circumference (MUAC) and are included based on a weight-for-height Z-score (WHZ) between - 3 and - 2 standard deviations (SD). As per current protocols, children receive renutrition treatment for 12 weeks and are assessed weekly to determine improvement. Read More

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December 2018
1 Read

Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with clinically node-positive breast cancer (TAXIS): study protocol for a multicenter, randomized phase-III trial.

Trials 2018 Dec 4;19(1):667. Epub 2018 Dec 4.

Breast Center, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.

Background: Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients for almost a century. In the 1990s, however, and in parallel with the advent of the sentinel lymph node (SLN) procedure, ALND came under increasing scrutiny due to its association with significant patient morbidity. Several studies have since provided evidence to suggest omission of ALND, often in favor of axillary radiation, in selected clinically node-negative, SLN-positive patients, thus supporting the current trend in clinical practice. Read More

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December 2018

Effect of dual-acupoint and single-acupoint electric stimulation on postoperative outcomes in elderly patients subjected to gastrointestinal surgery: study protocol for a randomized controlled trial.

Trials 2018 Dec 4;19(1):669. Epub 2018 Dec 4.

Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Background: Transcutaneous electric acupoint stimulation (TEAS) has shown benefits when used peri-operatively. However, the role of numbers of areas with acupoint stimulation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using TEAS in elderly patients subjected to gastrointestinal surgery, and comparing dual-acupoint and single-acupoint stimulation. Read More

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December 2018

"Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway.

Parasit Vectors 2018 Dec 4;11(1):620. Epub 2018 Dec 4.

Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: "Candidatus Neoehrlichia mikurensis" is a gram-negative bacterium belonging to the family Anaplasmataceae that, in Europe, is transmitted by Ixodes ricinus ticks. "Candidatus N. mikurensis" can cause a severe systemic inflammatory syndrome, neoehrlichiosis, mostly in persons with other underlying diseases. Read More

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December 2018