2,411 results match your criteria IUBMB Life [Journal]


Vitamin E - The Next 100 Years.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More

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December 2018

Detection of Malignancy-Associated Phosphoproteome Changes in Human Colorectal Cancer Induced by Cell Surface Binding of Growth-Inhibitory Galectin-4.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Department of Applied Tumor Biology, Institute of Pathology, Medical School of the Ruprecht-Karls-University, Heidelberg, Germany.

Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium. Read More

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December 2018

MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-β-smad2/3 signaling.

IUBMB Life 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hypoxia may play a vital role. It has been found the expression of microRNA-101 varied in bladder after BOO. Read More

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December 2018

No Lanthanides-based Catalysis in Eukaryotes.

IUBMB Life 2018 Dec 13. Epub 2018 Dec 13.

Interdepartmental Laboratory for Electron Microscopy, Roma Tre University, Roma, Italy.

In the "Hypothesis" paper entitled "Lanthanides-Based Catalysis in Eukaryotes" (IUBMB Life 2018 Nov;70(11):1067-1075), we analyzed the possibility that Ce -dependent methanol dehydrogenases (MDHs) could be found not only in archaea and bacteria but also in eukaryotic organisms. This hypothesis was based on the observation that MDHs protein sequences carrying the signature of Ce -based active sites could be found in genome-derived proteomes of the eukaryotes Plasmodium yoelii yoelii, Nephila clavipes, Hyalella azteca, Pantholops hodgsonii, and Homo sapiens. Data were analyzed following standard procedures employed in the study of phylogenetic relationships among members of protein families and their occurrence in diverse organisms. Read More

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December 2018

Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms.

Authors:
Qing Jiang

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.

The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Read More

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December 2018

Orange is the new black: Kinases are the new master regulators of tumor suppression.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD.

For many decades, kinases have predominantly been characterized as oncogenes and drivers of tumorigenesis, because activating mutations in kinases occur in cancer with high frequency. The oncogenic functions of kinases relate to their roles as growth factor receptors and as critical mediators of mitogen-activated pathways. Indeed, some of the most promising cancer therapeutic agents are kinase inhibitors. Read More

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December 2018
2 Reads

Tilorone activates NK cells and cytotoxic lymphocytes that kill HLA-negative tumor cells.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Molecular Immunogenetics of cancer laboratory, Institute of gene biology, RAS, Moscow, 119334, Russia.

Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recognize immune-evasive tumor cells and kill them via the FasL-Fas interaction. We have also performed a comparative analysis of characteristics between lymphocytes activated in the fraction of human peripheral blood mononuclear cells (PBMCs) upon treatment with different stimulants of the immune response: tilorone, innate immunity protein Tag7, and cytokine IL-2, a regulator of adaptive immunity. Read More

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December 2018
4 Reads

Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Aberrant activation of cyclin-dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, we report that CDK9 is gradually upregulated during cervical lesion progression and regulated by HPV16 E6. Read More

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December 2018

Correlation of Abrin-Mediated Inhibition of Protein Synthesis and Apoptosis.

IUBMB Life 2018 Dec 2. Epub 2018 Dec 2.

Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, India.

The plant toxin, abrin, a type-II ribosome inactivating protein, is extremely lethal, the human fatal dose being ~1 μg/kg body weight. Abrin has been classified as an agent for bioterrorism, which is of concern. Conversely, the high toxic property of abrin has been employed in generating immunotoxins, whereas its toxin moiety is conjugated to cell surface marker-specific antibodies for cell-targeted killing. Read More

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December 2018

Loss of m A on FAM134B promotes adipogenesis in porcine adipocytes through m A-YTHDF2-dependent way.

IUBMB Life 2018 Dec 2. Epub 2018 Dec 2.

College of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

N -methyladenosine (m A) mRNA modification plays an important role in adipogenesis, but its role on single gene remains unexplored. Family with Sequence Similarity 134, Member B (FAM134B) is a cis-Golgi transmembrane protein that known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in lipid homeostasis and was identified as its significant m A level difference between Chinese local Jinhua pigs and Landrace through RNA-sequence. Read More

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December 2018

Regulatory role of vitamin E in the immune system and inflammation.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, 02111, USA.

Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate immune function. Vitamin E deficiency has been demonstrated to impair normal functions of the immune system in animals and humans, which can be corrected by vitamin E repletion. Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to enhance the function of the immune system and reduce risk of infection, particularly in older individuals. Read More

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November 2018
6 Reads

Functional and structural characterization of a novel catechol-O-methyltransferase from Schizosaccharomyces pombe.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.

Catechol-O-methyltransferase (COMT ) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to various catechol substrates. COMTs play vital roles in physiological processes in animals, plants, and fungi, as well as bacteria, and have essential application values in industry. spCOMT is a probable COMT from Schizosaccharomyces pombe. Read More

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November 2018
1 Read

Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.

Long noncoding RNAs (lncRNAs), a family of noncoding RNA transcripts with a length of <200 nucleotides (nts), have been associated with the pathological development of various types of carcinogenesis. Focally amplified lncRNA on chromosome 1 (FAL1) is a recently identified lncRNA. In the current study, we aimed to investigate the physiological function of FAL1 in esophageal squamous cell carcinoma (ESCC). Read More

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November 2018
2 Reads

A method for the gross analysis of global protein acylation by gas-liquid chromatography.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran.

Protein acylation is a posttranslational modification in which an amino acid residue of a protein is acylated by a fatty acid. This process plays a key role in regulating proteomic function. Studies of protein acylation have relied on the development and application of extremely complicated molecular methods. Read More

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November 2018
1 Read

IL-17A-mediated ERK1/2/p65 Signaling Pathway is Associated with Cell Apoptosis after Non-alcoholic Steatohepatitis.

IUBMB Life 2018 Nov 27. Epub 2018 Nov 27.

Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Interleukin (IL)-17A is pro-inflammatory cytokine which has been identified as a noninvasive marker of the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the underlying role of IL-17A in NASH progression remains unclear. This study was designed to investigate the biological function and molecular mechanism of IL-17A in the induction of NASH. Read More

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November 2018

Ischemic preconditioning improved renal ischemia/reperfusion injury and hyperglycemia.

IUBMB Life 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood. The multiple renoprotective effects of IPC underscore the importance in understanding molecular mechanisms and the targets of action involved. Read More

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November 2018
6 Reads
3.140 Impact Factor

Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans.

IUBMB Life 2018 Nov 27. Epub 2018 Nov 27.

School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.

Isoquercitrin (ISO), one of phytochemical isolated from aerial parts of Aster yomena, has been reported to have antifungal activity. However, the synergistic effect and the mechanism of ISO in combination with conventional antifungal agents are poorly understood. Therefore, synergistic antifungal effect between ISO and conventional antifungal agents was investigated. Read More

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November 2018
7 Reads

Diagnostic and Prognostic Role of Serum miR-20b, miR-17-3p, HOTAIR, and MALAT1 in Diabetic Retinopathy.

IUBMB Life 2018 Nov 23. Epub 2018 Nov 23.

Department of Clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Noncoding RNAs are emerging biomarkers for many diseases including diabetic retinopathy (DR). This study aimed to measure the expression levels of serum miR-20b, miR-17-3p, HOTAIR, and MALAT1 in DR patients. A total of 80 patients diagnosed as type 2 diabetes (T2D) and 81 healthy subjects were recruited in this study. Read More

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November 2018
3.140 Impact Factor

Lung inflammation and disease: A perspective on microbial homeostasis and metabolism.

IUBMB Life 2018 Nov 22. Epub 2018 Nov 22.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

It is now well appreciated that the human microbiome plays a significant role in a number of processes in the body, significantly affecting its metabolic, inflammatory, and immune homeostasis. Recent research has revealed that almost every mucosal surface in the human body is associated with a resident commensal microbiome of its own. While the gut microbiome and its role in regulation of host metabolism along with its alteration in a disease state has been well studied, there is a lacuna in understanding the resident microbiota of other mucosal surfaces. Read More

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November 2018
6 Reads

Investigations on the mechanism of progesterone in inhibiting endometrial cancer cell cycle and viability via regulation of long noncoding RNA NEAT1/microRNA-146b-5p mediated Wnt/β-catenin signaling.

IUBMB Life 2018 Nov 19. Epub 2018 Nov 19.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People's Republic of China.

Progesterone is often used to protect the endometrium and prevent endometrial cancer. An intensive study on its molecular mechanism in endometrial cancer would contribute to the development of more promising therapies. Relevant lncRNAs and mRNAs expression data in endometrial cancer cell line Ishikawa pretreated and post-treated with progesterone were derived from Gene Expression Omnibus (accession no. Read More

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November 2018
2 Reads

Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway.

IUBMB Life 2018 Nov 19. Epub 2018 Nov 19.

Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, China.

Myofibroblast apoptosis is essential for normal resolution of wound repair, including cardiac infarction repair. Impaired cardiac myofibroblast (CMF) apoptosis is associated with excessive extracellular matrix (ECM) deposition, which could be responsible for pathological cardiac fibrosis. Conventionally, angiotensin II (Ang II), a soluble peptide, is implicated in fibrogenesis because it induces cardiac fibroblast (CFb) proliferation, differentiation, and collagen synthesis. Read More

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November 2018
8 Reads

Paracoccus denitrificans Oxidative Phosphorylation: Retentions, Gains, Losses, and Lessons En Route to Mitochondria.

IUBMB Life 2018 Dec 14;70(12):1214-1221. Epub 2018 Nov 14.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

There are many similarities between the oxidative phosphorylation apparatus of mitochondria and those found in the cytoplasmic membranes of alpha-proteobacteria, exemplified by Paracocus denitrificans. These similarities are reviewed here alongside consideration of the differences between mitochondrial and bacterial counterparts, as well as the loss from the modern mitochondria of many of the bacterial respiratory proteins. The assembly of c-type cytochromes is of particular evolutionary interest as the post-translational apparatus used in the alpha-proteobacteria is found in plants, and for example in eukyarotic species including algae of various kinds together with jakobids, but has been superseded by different systems in mitochondria of metazoans and trypanosomatids. Read More

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December 2018
3 Reads

MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression.

IUBMB Life 2018 Nov 12. Epub 2018 Nov 12.

Department of Cardiovascular Diseases, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.

Cardiovascular ischemic disease is a large class of diseases that are harmful to human health. The significant role of microRNAs (miRNAs) in terms of controlling cardiac injury has been reported in latest studies. MiR-98 is very important in regulating the apoptosis, the differentiation, the growth as well as the metastasis of cells. Read More

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November 2018
5 Reads

Characterization of mitochondrial proteomes of nonbilaterian animals.

IUBMB Life 2018 Dec 12;70(12):1289-1301. Epub 2018 Nov 12.

Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA, USA.

Mitochondria require ~1,500 proteins for their maintenance and proper functionality, which constitute the mitochondrial proteome (mt-proteome). Although a few of these proteins, mostly subunits of the electron transport chain complexes, are encoded in mitochondrial DNA (mtDNA), the vast majority are encoded in the nuclear genome and imported to the organelle. Previous studies have shown a continuous and complex evolution of mt-proteome among eukaryotes. Read More

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December 2018
7 Reads

Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease.

IUBMB Life 2018 Nov 10. Epub 2018 Nov 10.

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

This study aimed to detect the circulating oxidized low-density lipoprotein (ox-LDL) levels of controls and patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) and also to investigate the correlation with the severity of coronary heart disease (CHD). Plasma levels of circulating ox-LDL-4E6, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, apoprotein A, apoprotein B, and lipoprotein (a) (Lp(a)) were measured in 99 participants who underwent coronary angiography. The plasma ox-LDL level was significantly higher in patients with CHD than in controls (P = 0. Read More

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November 2018
5 Reads

BRENDA in 2019: a European ELIXIR core data resource.

Nucleic Acids Res 2018 Nov 5. Epub 2018 Nov 5.

Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany.

The BRENDA enzyme database (www.brenda-enzymes.org), recently appointed ELIXIR Core Data Resource, is the main enzyme and enzyme-ligand information system. Read More

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November 2018
8 Reads

Phytol as an anticarcinogenic and antitumoral agent: An in vivo study in swiss mice with DMBA-Induced breast cancer.

IUBMB Life 2018 Nov 5. Epub 2018 Nov 5.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil.

Phytol (PHY) (3,7,11,15-tetramethylhexadec-2-en-1-ol) exhibits various pharmacological properties including toxicity and cytotoxicity, and exerts antitumor activity. Owing to the urgent need of new pharmaceutical formulations for breast cancer therapy, this study aimed at the evaluation of antitumor activity of PHY in 7,12-dimethylbenzanthracene-cancer-induced animal model. Comet assay was employed to evaluate the cytogenetics, DNA repair, and antigenotoxic activities of PHY in neoplastic (breast) and non-neoplastic rodent cells (bone marrow, lymphocytes, and liver). Read More

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November 2018
5 Reads

Mitonuclear epistasis, genotype-by-environment interactions, and personalized genomics of complex traits in Drosophila.

IUBMB Life 2018 Dec 5;70(12):1275-1288. Epub 2018 Nov 5.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA.

Mitochondrial function requires the coordinated expression of dozens of gene products from the mitochondrial genome and hundreds from the nuclear genomes. The systems that emerge from these interactions convert the food we eat and the oxygen we breathe into energy for life, while regulating a wide range of other cellular processes. These facts beg the question of whether the gene-by-gene interactions (G x G) that enable mitochondrial function are distinct from the gene-by-environment interactions (G x E) that fuel mitochondrial activity. Read More

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December 2018
3 Reads

In vitro neurosphere formation correlates with poor survival in glioma.

IUBMB Life 2018 Nov 4. Epub 2018 Nov 4.

Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, 695011, India.

Sphere formation is an indicator of tumor aggressiveness independent of the tumor grade; however, its relation to progression-free survival (PFS) is less known. This study was designed to assess the neurosphere forming ability among low grade glioma (LGG) and high-grade glioma (HGG), its stem cell marker expression, and correlation to PFS. Tumor samples of 140 patients, including (LGG; n = 67) and (HGG; n = 73) were analyzed. Read More

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November 2018
3 Reads

The story of PKC: A discovery marked by unexpected twists and turns.

Authors:
Ushio Kikkawa

IUBMB Life 2018 Nov 4. Epub 2018 Nov 4.

Biosignal Research Center, Kobe University, Kobe, Japan.

Protein kinase C (PKC) is activated by 1,2-diacylglycerol as a second messenger in the signaling mechanism coupled with the hydrolysis of membrane inositol phospholipids, although it was not found by screening for a 1,2-diacylglycerol-dependent enzyme. PKC is also a receptor for the tumor-promoting phorbol esters, but it was not identified by its property of binding phorbol esters, either. Instead, the discovery and characterization of PKC, now known to comprise a family with multiple isoforms, was through a circuitous voyage filled with unexpected twists and turns. Read More

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November 2018

Long Non-coding RNA SNHG16 has Tumor Suppressing Effect in Acute Lymphoblastic Leukemia by Inverse Interaction on hsa-miR-124-3p.

IUBMB Life 2018 Oct 31. Epub 2018 Oct 31.

Department of Hematology, Zhejiang Province People's Hospital, Hangzhou, 310014, China.

Acute lymphoblastic leukemia (ALL) is one of the deadly forms of childhood cancers in the world. In the present study, we used both in vitro and in vivo models to evaluate the functional mechanisms of a long noncoding RNA (lncRNA), small nucleolar RNA host gene 16 (SNHG16) in ALL. SNHG16 gene expression was evaluated by quantitative real-time PCR (qPCR) in both in vitro ALL cell lines and in vivo human samples of T lymphocytes. Read More

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October 2018
3 Reads

Loss of TP53I11 Enhances the Extracellular Matrix-independent Survival by Promoting Activation of AMPK.

IUBMB Life 2018 Oct 30. Epub 2018 Oct 30.

CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Jiangsu, China.

Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and migration in MCF10A cells. TP53I11 has long been considered as a transcriptional target of TP53. Read More

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October 2018
3 Reads

SecinH3 Attenuates TDP-43 p.Q331K-Induced Neuronal Toxicity by Suppressing Endoplasmic Reticulum Stress and Enhancing Autophagic Flux.

IUBMB Life 2018 Oct 30. Epub 2018 Oct 30.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset, neurodegenerative disease. The transactivating response region DNA binding protein 43 (TDP-43) p.Q331K mutation (TDP-43 Q331K) has previously been identified in ALS as a disease-causing mutation with neurotoxicity. Read More

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October 2018
6 Reads

Challenges during diapause and anhydrobiosis: Mitochondrial bioenergetics and desiccation tolerance.

IUBMB Life 2018 Dec 10;70(12):1251-1259. Epub 2018 Oct 10.

Department of Biological Sciences, Division of Cellular Developmental and Integrative Biology, Louisiana State University, LA, USA.

In preparation for the onset of environmental challenges like overwintering, food limitation, anoxia, or water stress, many invertebrates and certain killifish enter diapause. Diapause is a developmentally-programed dormancy characterized by suppression of development and metabolism. For embryos of Artemia franciscana (brine shrimp), the metabolic arrest is profound. Read More

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December 2018
1 Read

SLC1A2 mediates refractory temporal lobe epilepsy with an initial precipitating injury by targeting the glutamatergic synapse pathway.

IUBMB Life 2018 Oct 25. Epub 2018 Oct 25.

Department of Neurosurgery and Laboratory of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China.

This study aimed to identify the genes related to epilepsy and their effects on epilepsy, as well as the underlying mechanism. Using microarray analysis, differentially expressed genes (DEGs) were screened out and then used to build weighted gene coexpression networks using WGCNA. Module membership and evaluation of gene significance (GS) were adopted to detect hub genes. Read More

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October 2018
3 Reads

Evolutionary mitochondrial biology in titisee.

IUBMB Life 2018 Dec 24;70(12):1184-1187. Epub 2018 Oct 24.

Howard Hughes Medical Institute and Department of Molecular Biology, Massachsuetts General Hospital, Boston, MA, USA.

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December 2018
5 Reads

How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.

IUBMB Life 2018 Dec 25;70(12):1207-1213. Epub 2018 Oct 25.

Department of Microbiology, Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University, Columbus, OH, USA.

Organisms have evolved different strategies to seclude certain molecules to specific locations of the cell. This is most pronounced in eukaryotes with their extensive intracellular membrane systems. Intracellular compartmentalization is particularly critical in genome containing organelles, which because of their bacterial evolutionary ancestry still maintain protein-synthesis machinery that resembles more their evolutionary origin than the extant eukaryotic cell they once joined as an endosymbiont. Read More

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December 2018
5 Reads

Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis.

Authors:
Toni Gabaldón

IUBMB Life 2018 Dec 25;70(12):1188-1196. Epub 2018 Oct 25.

Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

The origin of eukaryotes stands as a major open question in biology. Central to this question is the nature and timing of the origin of the mitochondrion, an ubiquitous eukaryotic organelle originated by the endosymbiosis of an alphaproteobacterial ancestor. Different hypotheses disagree, among other aspects, on whether mitochondria were acquired early or late during eukaryogenesis. Read More

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December 2018
6 Reads

Ubiquitin-independent, Proteasome-mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system.

IUBMB Life 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, Zhengzhou University, 1st Affiliated Hospital, Zhengzhou, China.

The oncogene KRAS not only promotes the tumorigenesis of pancreatic cancers but also is required for the malignant progression and metastasis of these cancers. Many methods have been explored to influence the malignant biological behavior of these cancers by targeting mutant KRAS. The ornithine decarboxylase/antizyme (ODC/AZ) system is another protein degradation pathway that exists in nature. Read More

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October 2018
1 Read
3.140 Impact Factor

Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract.

IUBMB Life 2018 Oct 17. Epub 2018 Oct 17.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, China.

Endoplasmic reticulum stress (ERS)-induced apoptosis of airway epithelial cells plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Furthermore, autophagy is closely related to ERS under apoptosis. Here, this study aimed to investigate the role of the reciprocal interaction between autophagy and ERS in the cigarette smoke extract (CSE)-induced apoptosis of human bronchial epithelial (HBE) cells. Read More

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October 2018
1 Read

miR-199b-5p-Stonin 2 axis regulates metastases and epithelial-to-mesenchymal transition of papillary thyroid carcinoma.

IUBMB Life 2018 Oct 16. Epub 2018 Oct 16.

Department of Endocrinology, the First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, 450002, China.

Papillary thyroid carcinoma is one of the most fatal malignant endocrine tumors, and the prognosis remains poor because of the lack of effective therapeutic targets. In this study, we demonstrated that the level of miR-199b-5p was markedly downregulated in papillary thyroid carcinoma. The ectopic expression level of miR-199b-5p in papillary thyroid carcinoma cell B-CPAP could inhibit growth, migration, and invasion as well as epithelial-mesenchymal transition (EMT) and decreased cell metastasis in vivo, but silencing miR-199b-5p caused a contradictory outcome. Read More

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October 2018
3 Reads

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation.

IUBMB Life 2018 Oct 15. Epub 2018 Oct 15.

Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Ferroptosis is recently reported as a new mode of regulated cell death. Its essential characteristics are disturbed redox homeostasis, overloaded iron, and increased lipid peroxidation. However, the role of ferroptosis in liver fibrosis remains poorly understood. Read More

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October 2018
5 Reads
3.140 Impact Factor

MicroRNA-107 regulates anesthesia-induced neural injury in embryonic stem cell derived neurons.

IUBMB Life 2018 Oct 11. Epub 2018 Oct 11.

Department of Anesthesiology, Fujian Provincial Hospital, Provincial Clinical Medical College, Fujian Medical University, Fujian, China.

Ketamine, though widely used in pediatric anesthesia, may induce cortical neurotoxicity in young patients. This study focused on an in vitro model of rat brain embryonic stem cell (ESC)-derived neurons to investigate the effects of microRNA-107 (miR-107) on ketamine-induced neural injury. Rat brain ESCs were proliferated in vitro and differentiated toward neuronal fate. Read More

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October 2018

Anticancer activity of thymol: A literature-based review and docking study emphasized on its anticancer mechanisms.

IUBMB Life 2018 Oct 11. Epub 2018 Oct 11.

Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, Bangladesh.

This review aims to summarize the anticancer effects of the natural monoterpene phenol derivative of cymenethymol and its derivatives as well as further molecular docking study to correlate the interaction of thymol and biomacromolecules that involved in cancer cell growth. For this, an up-to-date (till July 2018) literature study were made through using PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society, Clinicaltrials.gov, and Google Scholar databases. Read More

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October 2018
3 Reads

Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte.

IUBMB Life 2018 Oct 11. Epub 2018 Oct 11.

Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France.

Vitamin E is an essential molecule for our development and health. It has long been thought that it was absorbed and transported through cellular membranes by a passive diffusion process. However, data obtained during the past 15 years showed that its absorption is actually mediated, at least in part, by cholesterol membrane transporters including the scavenger receptor class B type I (SR-BI), CD36 molecule (CD36), NPC1-like transporter 1 (NPC1L1), and ATP-binding cassettes A1 and G1 (ABCA1 and ABCG1). Read More

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October 2018
9 Reads

Perfection of eccentricity: Mitochondrial genomes of diplonemids.

IUBMB Life 2018 Dec 10;70(12):1197-1206. Epub 2018 Oct 10.

Département de Biochimie, Robert Cedergren Centre for Bioinformatics and Genomics, Université de Montréal, Montréal, Québec, Canada.

Mitochondria are the sandbox of evolution as exemplified most particularly by the diplonemids, a group of marine microeukaryotes. These protists are uniquely characterized by their highly multipartite mitochondrial genome and systematically fragmented genes whose pieces are spread out over several dozens of chromosomes. The type species Diplonema papillatum was the first member of this group in which the expression of fragmented mitochondrial genes was investigated experimentally. Read More

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December 2018

UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.

IUBMB Life 2018 Oct 10. Epub 2018 Oct 10.

Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China.

Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). In this study, using data from the Cancer Genome Atlas (TCGA), we analyzed the expression profile of uridine-cytidine kinase genes in hepatocellular carcinoma (HCC), their prognostic value, and the epigenetic alterations associated with their dysregulation. Results showed that UCKL1 and UCK2, but not UCK1 were significantly upregulated in HCC tissues than in adjacent normal tissues. Read More

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October 2018

MCL1 Gene Silencing Promotes Senescence and Apoptosis of Glioma Cells via Inhibition of the PI3K/Akt Signaling Pathway.

IUBMB Life 2018 Oct 8. Epub 2018 Oct 8.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou, 221116, China.

Glioma is known to be the most prevalent primary brain tumor. In recent years, there has been evidence indicating myeloid cell leukemia-1 (MCL1) plays a role in brain glioblastoma. Therefore, the present study was conducted with aims of exploring the ability of MCL1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Read More

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October 2018
3 Reads

Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia?

IUBMB Life 2018 Nov 8;70(11):1057-1066. Epub 2018 Oct 8.

Department of Sciences, Roma Tre University, Roma, Italy.

Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the expansion of hematopoietic stem/progenitor cells (HPCs) blocked at different stages of maturation/differentiation. The poor outcome of AMLs necessitates therapeutic improvement. In AML, genes encoding for myeloid transcription factors, signaling receptors regulating cell proliferation, and epigenetic modifiers can be mutated by somatically acquired genetic mutations or altered by chromosomal translocations. Read More

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November 2018
2 Reads

Massive mitochondrial DNA content in diplonemid and kinetoplastid protists.

IUBMB Life 2018 Dec 6;70(12):1267-1274. Epub 2018 Oct 6.

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.

The mitochondrial DNA of diplonemid and kinetoplastid protists is known for its suite of bizarre features, including the presence of concatenated circular molecules, extensive trans-splicing and various forms of RNA editing. Here we report on the existence of another remarkable characteristic: hyper-inflated DNA content. We estimated the total amount of mitochondrial DNA in four kinetoplastid species (Trypanosoma brucei, Trypanoplasma borreli, Cryptobia helicis, and Perkinsela sp. Read More

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December 2018