2,351 results match your criteria IUBMB Life [Journal]


Long noncoding RNA MALAT1 mediates high glucose-induced glomerular endothelial cell injury by epigenetically inhibiting klotho via methyltransferase G9a.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Several recent reporters have indicated the potential role of long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in diabetic nephropathy (DN). However, these studies mainly focus on renal tubular epithelial cells HK-2, the role of MALAT1 in human renal glomerular endothelial cells (HRGECs) remains unclear. Hence, this study aimed to explore the role of MALAT1 in high glucose (HG)-induced HRGECs injury and the underlying epigenetic mechanism. Read More

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http://dx.doi.org/10.1002/iub.2009DOI Listing
February 2019

Bioinformatic Analysis of Cacybp-Associated Proteins Using Human Glioma Databases.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Hematology, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu.

The ubiquitin-proteasome system is the primary cellular pathway for protein degradation, mediating 80% of intracellular protein degradation. Because of the widespread presence of ubiquitin-modified protein substrates, ubiquitination can regulate a variety of cellular activities including cell proliferation, apoptosis, autophagy, endocytosis, DNA damage repair, and immune responses. With the continuous generation of genomics data in recent years it has become particularly important to analyze these data effectively and reasonably. Read More

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http://dx.doi.org/10.1002/iub.1999DOI Listing
February 2019

Mitochondrial Dysfunctions in Barth Syndrome.

IUBMB Life 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

Barth syndrome (BTHS) is a rare multisystemic genetic disorder caused by mutations in the TAZ gene. TAZ encodes a mitochondrial enzyme that remodels the acyl chain composition of newly synthesized cardiolipin, a phospholipid unique to mitochondrial membranes. The clinical abnormalities observed in BTHS patients are caused by perturbations in various mitochondrial functions that rely on remodeled cardiolipin. Read More

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http://dx.doi.org/10.1002/iub.2018DOI Listing
February 2019
1 Read

MicroRNA-365 Promotes the Contractile Phenotype of Venous Smooth Muscle Cells and Inhibits Neointimal Formation in Rat Vein Grafts.

IUBMB Life 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiothoracic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

The high rate of autologous vein graft failure caused by neointimal hyperplasia remains an unresolved issue in the field of cardiovascular surgery; therefore, it is important to explore new methods for protecting against neointimal hyperplasia. MicroRNA-365 has been reported to inhibit the proliferation of vascular smooth muscle cells (SMCs). This study aimed to test whether adenovirus-mediated miR-365 was able to attenuate neointimal formation in rat vein grafts. Read More

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http://dx.doi.org/10.1002/iub.2022DOI Listing
February 2019
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Preface to IUBMB-Life 2019: Vitamin E-Regulatory Roles.

Authors:
Jean-Marc Zingg

IUBMB Life 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.2017DOI Listing
February 2019

Preptin Promotes Proliferation and Osteogenesis of MC3T3-E1 Cells by Upregulating β-Catenin Expression.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Rheumatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Preptin, an oligopeptide secreted by pancreatic β-cell, plays a significant role in glycometabolism and bone metabolism. Preptin strengthens proliferation and differentiation of osteoblasts, but the mechanism is unclear. Here, we explored the role of the Wnt/β-catenin signaling pathway which is well known to affect bone development and remodelling in the function of preptin. Read More

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http://dx.doi.org/10.1002/iub.2016DOI Listing
February 2019
1 Read
3.143 Impact Factor

Therapeutic potential of toll-like receptors in treatment of gynecological cancers.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Toll-like receptors (TLRs) play an important role in the innate and adaptive immune system. They are expressed in various regions of the female reproductive tract, and their regulation may be involved in the pathogenesis of gynecological lesions. There is growing evidence that ligands for several TLRs are potentially anticancer agents, some of which have already been approved by the FDA, and these compounds are now undergoing clinical evaluation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2011
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http://dx.doi.org/10.1002/iub.2011DOI Listing
February 2019
1 Read

T cell engineered with a novel nanobody-based chimeric antigen receptor against VEGFR2 as a candidate for tumor immunotherapy.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Immunology, Hybridoma Lab, Pasteur Institute of Iran, Tehran, Iran.

Solid tumors that are responsible for more than 85% of cancer death cases need angiogenesis for their growth and metastasis. Among antiangiogenic therapies, targeting the vascular endothelial growth factor receptor 2 (VEGFR2) that is over-expressed on tumor vasculatures has been a promising strategy. In this study, we developed a second generation nanobody (VHH)-based CAR T cell targeting VEGFR2-expressing tumor cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2019
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http://dx.doi.org/10.1002/iub.2019DOI Listing
February 2019
2 Reads

Serum Exosomal microRNA Let-7i-3p as Candidate Diagnostic Biomarker for Kawasaki Disease Patients with Coronary Artery Aneurysm.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Biological Resource Bank, Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Kawasaki disease (KD) is a systemic vasculitis syndrome that leads to coronary artery aneurysm (CAA). While echocardiography is the most important imaging modality for coronary artery assessment, a specific diagnostic biomarker complementary for CAA has not been reported. We aimed to analyze the profiles of exosomal miRNAs extracted from the serum of KD patients and controls to identify candidate biomarkers for CAA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2015
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http://dx.doi.org/10.1002/iub.2015DOI Listing
February 2019
2 Reads
3.143 Impact Factor

3,5-diiodo-L-thyronine increases de novo lipogenesis in liver from hypothyroid rats by SREBP-1 and ChREBP-mediated transcriptional mechanisms.

IUBMB Life 2019 Feb 1. Epub 2019 Feb 1.

Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100, Lecce, Italy.

Hepatic de novo lipogenesis (DNL), the process by which carbohydrates are converted into lipids, is strictly controlled by nutritional and hormonal status. 3,5-Diiodo-L-thyronine (T2), a product of the 3,5,3'-triiodo-L-thyronine (T3) peripheral metabolism, has been shown to mimic some T3 effects on lipid metabolism by a short-term mechanism independent of protein synthesis. Here, we report that T2, administered for 1 week to hypothyroid rats, increases total fatty acid synthesis from acetate in isolated hepatocytes. Read More

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http://dx.doi.org/10.1002/iub.2014DOI Listing
February 2019
2 Reads

The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug.

IUBMB Life 2019 Jan 14. Epub 2019 Jan 14.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

The observations that the innate immune system employs copper to eliminate bacterial infection and that resistance to copper enhances virulence of Mycobacterium tuberculosis (Mtb) prompted us to examine the effects the anti-cancer agent elesclomol on Mtb. As a bis-thionohydrazide, elesclomol chelates with copper to form a copper complex in situ that via redox cycling of the metal ion greatly enhances oxidative stress in tumour cells. Here, we demonstrate that elesclomol is relatively potent against Mtb H37Rv with minimum inhibitory concentration of 10 μM (4 mg/L) and against multidrug resistant clinical isolates of Mtb, displays additive interactions with known tuberculosis drugs such as isoniazid and ethambutol, and a synergistic interaction with rifampicin. Read More

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http://dx.doi.org/10.1002/iub.2002DOI Listing
January 2019

Hydroxycamptothecin Prevents Fibrotic Pathways in Fibroblasts In Vitro.

IUBMB Life 2019 Jan 28. Epub 2019 Jan 28.

Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Peritendinous fibrosis, which leads to impaired tendon function, is a clinical problem worldwide, and it is urgent to explore potential ways to reduce the formation of peritendinous adhesion. Several studies have demonstrated the biological roles of hydroxycamptothecin (HCPT) in inhibiting fibrosis in different tissues. In this study, we investigated whether HCPT could inhibit tendon fibrosis in vitro. Read More

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http://dx.doi.org/10.1002/iub.2013DOI Listing
January 2019

Vitamin E: Regulatory Redox Interactions.

IUBMB Life 2019 Jan 25. Epub 2019 Jan 25.

Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.

Vitamin E is an essential nutrient that was discovered in the 1920s. Many of the physiological functions of vitamin E, including its antioxidative effects, have been studied for nearly 100 years. Changes in redox balance induced by both endogenously and exogenously generated reactive oxygen species (ROS) are involved in various diseases, and are also a phenomenon that is considered essential for survival. Read More

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http://dx.doi.org/10.1002/iub.2008DOI Listing
January 2019

Ameliorating the antimicrobial resistance crisis: phage therapy.

IUBMB Life 2019 Jan 23. Epub 2019 Jan 23.

Department of Biology, Indian Institute of Science Education and Research, Tirupati, India.

Propelled by the overuse and inappropriate use of antibiotics, antimicrobial resistance is now widespread in the environment, leaving us with limited drugs for treating a large number of resistant pathogens. The use of bacteriophages that kill bacteria has come up as a viable alternative to circumvent the antimicrobial resistance crisis, and phage therapy-based approaches are fast advancing in recent times. In this minireview, we try to describe the advantages associated with phage therapy and update the latest developments in the field including the clinical trials that are underway. Read More

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http://dx.doi.org/10.1002/iub.2010DOI Listing
January 2019

The tumour suppressing role of the circadian clock.

IUBMB Life 2019 Jan 23. Epub 2019 Jan 23.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

The circadian clock and the ~24 h rhythms it generates are essential in maintaining regular tissue functioning. At the molecular level, the circadian clock comprises a core set of rhythmically expressed genes and gene products that are able to drive rhythmic expression of other genes to generate overt circadian rhythms. It has recently come to light that perturbations of circadian rhythms contribute to the development of pathological states such as cancer, and altered expression and/or regulation of circadian clock genes has been identified in multiple tumour types. Read More

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http://dx.doi.org/10.1002/iub.2005DOI Listing
January 2019

Transplacental Delivery of Genome Editing Components Causes Mutations in Embryonic Cardiomyocytes of Mid-Gestational Murine Fetuses.

IUBMB Life 2019 Jan 11. Epub 2019 Jan 11.

Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima, Kagoshima, 890-8544, Japan.

Genome editing, as exemplified by CRISPR/Cas9, is now recognized as a powerful tool for the engineering of endogenous target genes. It employs only two components, namely, Cas9 in the form of DNA, mRNA, or protein; and guide RNA (gRNA), which is specific to a target gene. When these components are transferred to cells, they create insertion/deletion mutations (indels) within a target gene. Read More

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http://doi.wiley.com/10.1002/iub.2004
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http://dx.doi.org/10.1002/iub.2004DOI Listing
January 2019
6 Reads

Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles.

IUBMB Life 2019 Jan 11. Epub 2019 Jan 11.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Read More

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http://doi.wiley.com/10.1002/iub.2003
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http://dx.doi.org/10.1002/iub.2003DOI Listing
January 2019
5 Reads

Nutritional evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae.

IUBMB Life 2019 Jan 10. Epub 2019 Jan 10.

Ligno Biotech Sdn. Bhd., Seri Kembangan, Selangor, Malaysia.

Sclerotial powder of a cultivated species of the Tiger Milk Mushroom, Lignosus cameronensis was analysed for its nutritional components and compared against species of the same genus, Lignosus rhinocerus and Lignosus tigris. All three species have been used by indigenous tribes in Peninsular Malaysia as medicinal mushrooms. Content of carbohydrate, fibre, mineral, amino acid, palatable index, fat, ash and moisture were determined. Read More

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http://doi.wiley.com/10.1002/iub.2006
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http://dx.doi.org/10.1002/iub.2006DOI Listing
January 2019
14 Reads

LncRNA MIAT Facilitates Osteosarcoma Progression by Regulating miR-128-3p/VEGFC Axis.

IUBMB Life 2019 Jan 10. Epub 2019 Jan 10.

School of Life Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.

The aberrant expression of long non-coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction-associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. Read More

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http://dx.doi.org/10.1002/iub.2001DOI Listing
January 2019
1 Read

The "great" controlling nucleotide coenzymes.

IUBMB Life 2019 Jan 9. Epub 2019 Jan 9.

Department of Biomedical Sciences, East Tennessee State University College of Medicine, Johnson City, TN, USA.

Nucleotide coenzymes dot the map of metabolic pathways providing energy to drive the reactions of the pathway and play an important role in regulating and controlling energy metabolism through their shared potential energy, which is widely unobserved due to the paradox that the energy in the coenzyme pools cannot be determined from the concentration of the coenzyme couples. The potential energy of the nucleotide couples in the mitochondria or the cytoplasm is expressed in the enzyme reactions in which they take part. The energy in these couples, [NAD+]/[NADH], [NADP+]/[NADPH], [acetyl CoA]/[CoA], and [ATP]/[ADP]x[Pi], regulates energy metabolism. Read More

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http://doi.wiley.com/10.1002/iub.1997
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http://dx.doi.org/10.1002/iub.1997DOI Listing
January 2019
8 Reads

Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism.

IUBMB Life 2019 Jan 7. Epub 2019 Jan 7.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.

Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association. The absence of structures involving competent enzymes bound to substrate/products came in the way of the precise elucidation of the catalytic mechanism of this family of proteins. Crystal structures of the enzyme from Mycobacterium tuberculosis in an unliganded form and its complex with the substrate/products have now been determined at 2. Read More

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http://dx.doi.org/10.1002/iub.2000DOI Listing
January 2019

RING finger protein 10 attenuates vascular restenosis by inhibiting vascular smooth muscle cell hyperproliferation in vivo and vitro.

IUBMB Life 2018 Dec 30. Epub 2018 Dec 30.

Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Vascular smooth muscle cell (VSMC) hyperproliferation is the main pathological process in various cardiovascular diseases, such as vascular restenosis. This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Read More

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http://dx.doi.org/10.1002/iub.1995DOI Listing
December 2018
1 Read

LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation.

IUBMB Life 2018 Dec 28. Epub 2018 Dec 28.

Department of the Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Long noncoding RNAs (LncRNAs) may serve as miRNA sponges to regulate the expressions of miRNA target genes. LncRNA LINC00969 has been indicated to be upregulated in intervertebral disk degeneration. However, the regulatory mechanism of LINC00969 in intervertebral disk degeneration progression remains unclear. Read More

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http://dx.doi.org/10.1002/iub.1989DOI Listing
December 2018

Role of vitamin E in nonalcoholic fatty liver disease.

IUBMB Life 2018 Dec 27. Epub 2018 Dec 27.

Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD manifests as hepatic lipid accumulation, insulin resistance, and inflammation, and can progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. However, the underlying mechanisms of NAFLD, including those that drive its progression, are unclear. Read More

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http://dx.doi.org/10.1002/iub.1991DOI Listing
December 2018

MicroRNA-23a inhibits melanoma cell proliferation, migration, and invasion in mice through a negative feedback regulation of sdcbp and the MAPK/ERK signaling pathway.

IUBMB Life 2018 Dec 27. Epub 2018 Dec 27.

Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Center of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China.

Melanoma is the main cause of death associated with skin cancer. Surgical resection and adjuvant therapy are currently effective treatments, but the recurrence rate is very high. The understanding of microRNA (miR) dynamics after surgical resection of melanoma is essential to accurately explain the changes in the recurrence of melanoma. Read More

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http://doi.wiley.com/10.1002/iub.1979
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http://dx.doi.org/10.1002/iub.1979DOI Listing
December 2018
4 Reads

Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent.

IUBMB Life 2018 Dec 27. Epub 2018 Dec 27.

Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrobial, antifungal, anti-inflammatory, and anticancer effects. Therefore, seven different samples were collected from different regions (Argentina, China, and Istanbul-Turkey) and applied on nonaggressive breast cancer cell line (BCCL) MCF-7 and aggressive cell lines SK-BR-3, and MDA-MB-231. Read More

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http://doi.wiley.com/10.1002/iub.1996
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http://dx.doi.org/10.1002/iub.1996DOI Listing
December 2018
11 Reads

New paradigm of functional regulation by DNA mimic proteins: Recent updates.

IUBMB Life 2018 Dec 22. Epub 2018 Dec 22.

Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.

For many, "DNA mimic protein" (DMP) remains an unfamiliar term. The key feature of these proteins is their DNA-like shape and charge distribution, and they affect the activity of DNA-binding proteins by occupying their DNA-binding domains. Functionally, DMPs regulate mechanisms such as gene expression, restriction, and DNA repair as well as the nucleosome package. Read More

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http://doi.wiley.com/10.1002/iub.1992
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http://dx.doi.org/10.1002/iub.1992DOI Listing
December 2018
9 Reads

Vitamin E: Regulatory role of metabolites.

IUBMB Life 2018 Dec 22. Epub 2018 Dec 22.

Department of Nutritional Biochemistry and Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany.

Vitamin E plays an important role as a lipophilic antioxidant in cellular redox homeostasis. Besides this function, numerous non-antioxidant properties of this vitamin have been discovered in the past. DNA microarray technology revealed a complex regulatory network influenced by the different vitamin E forms (Rimbach et al. Read More

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http://dx.doi.org/10.1002/iub.1988DOI Listing
December 2018

Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis.

IUBMB Life 2018 Dec 21. Epub 2018 Dec 21.

Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, 31151, Republic of Korea.

Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside Rd on the metastasis of colorectal cancer (CRC) remains unknown. Here, we found that ginsenoside Rd decreased the colony-forming ability, migration, invasion, and wound-healing abilities of CRC cells, although it did not affect cell proliferation. Read More

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http://dx.doi.org/10.1002/iub.1984DOI Listing
December 2018
1 Read

Effect of naturally occurring variations of the F-type lectin sequence motif on glycan binding: studies on F-type lectin domains with typical and atypical sequence motifs.

IUBMB Life 2019 Mar 19;71(3):385-397. Epub 2018 Dec 19.

Institute of Microbial Technology, Chandigarh, 160036, India.

The typical F-type lectin domain (FLD) has an L-fucose-binding motif [HX(26)RXDX(4)R/K] with conserved basic residues that mediate hydrogen bonding with alpha-L-fucose. About one-third of the nonredundant FLD sequences in the publicly available databases are "atypical"; they have motifs with substitutions of these critical residues and/or variations in motif length. We addressed the question if atypical FLDs with substitutions of the critical residues retain lectin activity by performing site-directed mutagenesis and assessing the glycan-binding functions of typical and atypical FLDs. Read More

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http://dx.doi.org/10.1002/iub.1994DOI Listing
March 2019
3.143 Impact Factor

Vitamin E: Mechanism of transport and regulation in the CNS.

IUBMB Life 2018 Dec 17. Epub 2018 Dec 17.

Ursuline College, Department of Biology, 2550 Lander Rd Pepper Pike, Ohio 44124.

Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis of neurological-related vitamin E deficient diseases point to compromised neuronal integrity and function, underlining the critical need to understand vitamin E regulation in the CNS. Read More

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http://dx.doi.org/10.1002/iub.1993DOI Listing
December 2018
2 Reads

Vitamin E: Regulatory Role on Signal Transduction.

Authors:
Jean-Marc Zingg

IUBMB Life 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a hydrophobic molecule located mainly in membranes it contributes together with other lipids to the physical and structural characteristics such as membrane stability, curvature, fluidity, and the organization into microdomains (lipid rafts). By acting as the main lipid-soluble antioxidant, it protects other lipids such as mono- and poly-unsaturated fatty acids (MUFA and PUFA, respectively) against chemical reactions with reactive oxygen and nitrogen species (ROS and RNS, respectively) and prevents membrane destabilization and cellular dysfunction. Read More

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http://doi.wiley.com/10.1002/iub.1986
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http://dx.doi.org/10.1002/iub.1986DOI Listing
December 2018
3 Reads

Vitamin E - The Next 100 Years.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More

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http://dx.doi.org/10.1002/iub.1990DOI Listing
December 2018
1 Read

Detection of malignancy-associated phosphoproteome changes in human colorectal cancer induced by cell surface binding of growth-inhibitory galectin-4.

IUBMB Life 2019 Mar 14;71(3):364-375. Epub 2018 Dec 14.

Department of Applied Tumor Biology, Institute of Pathology, Medical School of the Ruprecht-Karls-University, Heidelberg, Germany.

Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium. Read More

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http://dx.doi.org/10.1002/iub.1987DOI Listing
March 2019
2 Reads

MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-β-smad2/3 signaling.

IUBMB Life 2019 Feb 13;71(2):235-243. Epub 2018 Dec 13.

Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hypoxia may play a vital role. It has been found the expression of microRNA-101 varied in bladder after BOO. Read More

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http://dx.doi.org/10.1002/iub.1968DOI Listing
February 2019

No lanthanides-based catalysis in eukaryotes.

IUBMB Life 2019 Mar 13;71(3):398-399. Epub 2018 Dec 13.

Interdepartmental Laboratory for Electron Microscopy, Roma Tre University, Roma, Italy.

In the "Hypothesis" paper entitled "Lanthanides-Based Catalysis in Eukaryotes" (IUBMB Life 2018 Nov;70(11):1067-1075), we analyzed the possibility that Ce -dependent methanol dehydrogenases (MDHs) could be found not only in archaea and bacteria but also in eukaryotic organisms. This hypothesis was based on the observation that MDHs protein sequences carrying the signature of Ce -based active sites could be found in genome-derived proteomes of the eukaryotes Plasmodium yoelii yoelii, Nephila clavipes, Hyalella azteca, Pantholops hodgsonii, and Homo sapiens. Data were analyzed following standard procedures employed in the study of phylogenetic relationships among members of protein families and their occurrence in diverse organisms. Read More

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http://dx.doi.org/10.1002/iub.1982DOI Listing
March 2019
1 Read

Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms.

Authors:
Qing Jiang

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.

The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Read More

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http://dx.doi.org/10.1002/iub.1978DOI Listing
December 2018

Orange is the new black: Kinases are the new master regulators of tumor suppression.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD.

For many decades, kinases have predominantly been characterized as oncogenes and drivers of tumorigenesis, because activating mutations in kinases occur in cancer with high frequency. The oncogenic functions of kinases relate to their roles as growth factor receptors and as critical mediators of mitogen-activated pathways. Indeed, some of the most promising cancer therapeutic agents are kinase inhibitors. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.1981
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http://dx.doi.org/10.1002/iub.1981DOI Listing
December 2018
9 Reads

Tilorone activates NK cells and cytotoxic lymphocytes that kill HLA-negative tumor cells.

IUBMB Life 2019 Mar 11;71(3):376-384. Epub 2018 Dec 11.

Molecular Immunogenetics of cancer laboratory, Institute of gene biology, RAS, Moscow, 119334, Russia.

Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recognize immune-evasive tumor cells and kill them via the FasL-Fas interaction. We have also performed a comparative analysis of characteristics between lymphocytes activated in the fraction of human peripheral blood mononuclear cells (PBMCs) upon treatment with different stimulants of the immune response: tilorone, innate immunity protein Tag7, and cytokine IL-2, a regulator of adaptive immunity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.1985
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http://dx.doi.org/10.1002/iub.1985DOI Listing
March 2019
12 Reads

Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway.

IUBMB Life 2019 Mar 11;71(3):347-356. Epub 2018 Dec 11.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Aberrant activation of cyclin-dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, we report that CDK9 is gradually upregulated during cervical lesion progression and regulated by HPV16 E6. Read More

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http://dx.doi.org/10.1002/iub.1983DOI Listing
March 2019
2 Reads

Correlation of abrin-mediated inhibition of protein synthesis and apoptosis.

IUBMB Life 2019 Mar 2;71(3):357-363. Epub 2018 Dec 2.

Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, India.

The plant toxin, abrin, a type-II ribosome inactivating protein, is extremely lethal, the human fatal dose being ~1 μg/kg body weight. Abrin has been classified as an agent for bioterrorism, which is of concern. Conversely, the high toxic property of abrin has been employed in generating immunotoxins, whereas its toxin moiety is conjugated to cell surface marker-specific antibodies for cell-targeted killing. Read More

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http://dx.doi.org/10.1002/iub.1980DOI Listing

Loss of m A on FAM134B promotes adipogenesis in porcine adipocytes through m A-YTHDF2-dependent way.

IUBMB Life 2018 Dec 2. Epub 2018 Dec 2.

College of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

N -methyladenosine (m A) mRNA modification plays an important role in adipogenesis, but its role on single gene remains unexplored. Family with Sequence Similarity 134, Member B (FAM134B) is a cis-Golgi transmembrane protein that known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in lipid homeostasis and was identified as its significant m A level difference between Chinese local Jinhua pigs and Landrace through RNA-sequence. Read More

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http://doi.wiley.com/10.1002/iub.1974
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http://dx.doi.org/10.1002/iub.1974DOI Listing
December 2018
7 Reads

Regulatory role of vitamin E in the immune system and inflammation.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, 02111, USA.

Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate immune function. Vitamin E deficiency has been demonstrated to impair normal functions of the immune system in animals and humans, which can be corrected by vitamin E repletion. Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to enhance the function of the immune system and reduce risk of infection, particularly in older individuals. Read More

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http://doi.wiley.com/10.1002/iub.1976
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http://dx.doi.org/10.1002/iub.1976DOI Listing
November 2018
6 Reads

Functional and structural characterization of a novel catechol-O-methyltransferase from Schizosaccharomyces pombe.

IUBMB Life 2019 Mar 30;71(3):330-339. Epub 2018 Nov 30.

Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.

Catechol-O-methyltransferase (COMT ) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to various catechol substrates. COMTs play vital roles in physiological processes in animals, plants, and fungi, as well as bacteria, and have essential application values in industry. spCOMT is a probable COMT from Schizosaccharomyces pombe. Read More

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http://dx.doi.org/10.1002/iub.1977DOI Listing
March 2019
2 Reads

Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics.

IUBMB Life 2019 Feb 30;71(2):254-260. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.

Long noncoding RNAs (lncRNAs), a family of noncoding RNA transcripts with a length of <200 nucleotides (nts), have been associated with the pathological development of various types of carcinogenesis. Focally amplified lncRNA on chromosome 1 (FAL1) is a recently identified lncRNA. In the current study, we aimed to investigate the physiological function of FAL1 in esophageal squamous cell carcinoma (ESCC). Read More

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http://dx.doi.org/10.1002/iub.1971DOI Listing
February 2019
2 Reads
3.143 Impact Factor

A method for the gross analysis of global protein acylation by gas-liquid chromatography.

IUBMB Life 2019 Mar 30;71(3):340-346. Epub 2018 Nov 30.

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran.

Protein acylation is a posttranslational modification in which an amino acid residue of a protein is acylated by a fatty acid. This process plays a key role in regulating proteomic function. Studies of protein acylation have relied on the development and application of extremely complicated molecular methods. Read More

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http://dx.doi.org/10.1002/iub.1975DOI Listing
March 2019
1 Read

IL-17A-mediated ERK1/2/p65 signaling pathway is associated with cell apoptosis after non-alcoholic steatohepatitis.

IUBMB Life 2019 Mar 27;71(3):302-309. Epub 2018 Nov 27.

Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Interleukin (IL)-17A is pro-inflammatory cytokine which has been identified as a noninvasive marker of the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the underlying role of IL-17A in NASH progression remains unclear. This study was designed to investigate the biological function and molecular mechanism of IL-17A in the induction of NASH. Read More

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http://dx.doi.org/10.1002/iub.1960DOI Listing

Ischemic preconditioning improved renal ischemia/reperfusion injury and hyperglycemia.

IUBMB Life 2019 Mar 27;71(3):321-329. Epub 2018 Nov 27.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood. The multiple renoprotective effects of IPC underscore the importance in understanding molecular mechanisms and the targets of action involved. Read More

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http://doi.wiley.com/10.1002/iub.1972
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http://dx.doi.org/10.1002/iub.1972DOI Listing
March 2019
13 Reads
3.143 Impact Factor

Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans.

IUBMB Life 2019 Feb 27;71(2):283-292. Epub 2018 Nov 27.

School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.

Isoquercitrin (ISO), one of phytochemical isolated from aerial parts of Aster yomena, has been reported to have antifungal activity. However, the synergistic effect and the mechanism of ISO in combination with conventional antifungal agents are poorly understood. Therefore, synergistic antifungal effect between ISO and conventional antifungal agents was investigated. Read More

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http://doi.wiley.com/10.1002/iub.1973
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http://dx.doi.org/10.1002/iub.1973DOI Listing
February 2019
17 Reads

Diagnostic and prognostic role of serum miR-20b, miR-17-3p, HOTAIR, and MALAT1 in diabetic retinopathy.

IUBMB Life 2019 Mar 23;71(3):310-320. Epub 2018 Nov 23.

Department of Clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Noncoding RNAs are emerging biomarkers for many diseases including diabetic retinopathy (DR). This study aimed to measure the expression levels of serum miR-20b, miR-17-3p, HOTAIR, and MALAT1 in DR patients. A total of 80 patients diagnosed as type 2 diabetes (T2D) and 81 healthy subjects were recruited in this study. Read More

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http://dx.doi.org/10.1002/iub.1970DOI Listing
March 2019
2 Reads
3.143 Impact Factor