2,378 results match your criteria IUBMB Life [Journal]


Melatonin Enhances Autophagy and Decreases Apoptosis Induced by nanosilica in RAW264.7 cells.

IUBMB Life 2019 Apr 24. Epub 2019 Apr 24.

Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Melatonin is one of the main hormones that regulate biological rhythms and have immunomodulation, anti-inflammatory, and antioxidation functions. In this study, we aimed to explore the effect of melatonin on the autophagy, apoptosis, and inflammatory reaction of macrophages (RAW264.7 cells) stimulated by nanosilica. Read More

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http://dx.doi.org/10.1002/iub.2055DOI Listing

miR-146a-5p Enhances Hepatitis B Virus Replication Through Autophagy to Promote Aggravation of Chronic Hepatitis B.

IUBMB Life 2019 Apr 24. Epub 2019 Apr 24.

Department of Infectious Diseases, Key Laboratory of Hunan Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan, China.

The objective of this study was to investigate the mechanism by which miR-146a-5p mediated autophagy and hepatitis B virus (HBV) replication. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the mRNA expression levels of miR-146a-5p and X-linked inhibitor of apoptosis (XIAP) and HBV DNA and RNA. The protein expression levels of XIAP, IκB-α, murine double minute 2 oncoprotein (MDM2) and p53, the phosphorylation of p65, and the conversion of light chain 3 (LC3)-I to LC3-II were detected by Western blotting. Read More

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http://dx.doi.org/10.1002/iub.2044DOI Listing

Toxic trans-Crotonaldehyde in Mitochondria Intercepted by Oxyresveratrol Contributing to Anticancer.

IUBMB Life 2019 Apr 23. Epub 2019 Apr 23.

College of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, China.

The aim of this study was to explore how the toxic trans-crotonaldehyde (TCA) in mitochondria or aldehyde dehydrogenase (ALDH) at different pHs was intercepted by oxyresveratrol (Oxy-Res) contributing to anticancer. Ultraviolet-visible (UV-vis) spectroscopy and Raman spectroscopy were employed. UV-vis spectra showed that the Oxy-Res red shifted the peak of the toxic TCA from 316 nm to 325 nm, while the peaks of the Oxy-Res shifted from 329 nm with 290 nm and 300 nm to 325 nm with 303 nm. Read More

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http://dx.doi.org/10.1002/iub.2051DOI Listing

Astrakurkurone, a Sesquiterpenoid from Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl-2 Family Proteins.

IUBMB Life 2019 Apr 12. Epub 2019 Apr 12.

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, WB, India.

Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus hygrometricus. We have discussed the structure and stability of astrakurkurone employing single-crystal X-ray crystallography and studied its potential apoptogenicity in hepatocellular carcinoma (HCC) cells. Read More

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http://dx.doi.org/10.1002/iub.2047DOI Listing
April 2019
1 Read

The GLP1 Receptor Agonist Liraglutide Protects Against Oxidized LDL-Induced Endothelial Inflammation and Dysfunction via KLF2.

IUBMB Life 2019 Apr 10. Epub 2019 Apr 10.

Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.

Cardiovascular complications are the major causes of the mortality and morbidities in diabetic patients. The diabetic patients have an increased risk of developing atherosclerosis, which could lead to heart attack and stroke. Glucagon-like peptide 1 (GLP-1) receptor agonists are a class of potent anti-glycemic agents to treat diabetes. Read More

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http://dx.doi.org/10.1002/iub.2046DOI Listing

PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice.

IUBMB Life 2019 Apr 9. Epub 2019 Apr 9.

Department of Biochemistry, Panjab University, Chandigarh, Punjab, India.

Despite the reported role of poly(ADP-ribose) polymerase (PARP) in asthma inflammation, its contribution during remodeling is not clearly known. The main aim of the current investigation was to examine the potential of olaparib, a pharmacological inhibitor of PARP against airway remodeling using an ovalbumin (OVA)-based murine model of chronic asthma. The results demonstrated that post-challenge olaparib treatment (5 mg/kg i. Read More

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http://dx.doi.org/10.1002/iub.2048DOI Listing
April 2019
2 Reads

Gold Nanoparticles and Polyethylene Glycol Alleviate Clinical Symptoms and Alter Cytokine Secretion in a Mouse Model of Experimental Autoimmune Encephalomyelitis.

IUBMB Life 2019 Apr 7. Epub 2019 Apr 7.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Gold nanoparticles (GNPs) are attractive nanoparticles with unique electronic and optical properties in the nanotechnology field and are widely used in various biomedical fields. Studies have shown that these particles also exhibit antioxidant and anti-inflammatory properties. On the other hand, polyethylene glycol (PEG) that used to stabilize GNPs also exhibits antioxidant and anti-inflammatory properties due to their membrane resealing properties. Read More

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http://dx.doi.org/10.1002/iub.2045DOI Listing
April 2019
1 Read
3.143 Impact Factor

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals.

IUBMB Life 2019 Apr 2. Epub 2019 Apr 2.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. Read More

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http://dx.doi.org/10.1002/iub.2040DOI Listing

What is the Best Solution to Manage Vitamin D Deficiency?

IUBMB Life 2019 Apr 1. Epub 2019 Apr 1.

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Nowadays, vitamin D deficiency is the most common nutritional deficiency worldwide. In addition to the skeletal effects, it is now recognized that vitamin D deficiency is associated with higher morbidity and mortality. Currently, optimizing serum concentration of 25-hydroxy vitamin D with targeted strategies is becoming one the most interesting topics of public health nutrition. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2038
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http://dx.doi.org/10.1002/iub.2038DOI Listing
April 2019
5 Reads

To be or not to be modified: Miscellaneous aspects influencing nucleotide modifications in tRNAs.

IUBMB Life 2019 Apr 1. Epub 2019 Apr 1.

Expression génétique microbienne, Institut de biologie physico-chimique (IBPC), UMR 8261, CNRS, Université Paris Diderot, Paris, France.

Transfer RNAs (tRNAs) are essential components of the cellular protein synthesis machineries, but are also implicated in many roles outside translation. To become functional, tRNAs, initially transcribed as longer precursor tRNAs, undergo a tightly controlled biogenesis process comprising the maturation of their extremities, removal of intronic sequences if present, addition of the 3'-CCA amino-acid accepting sequence, and aminoacylation. In addition, the most impressive feature of tRNA biogenesis consists in the incorporation of a large number of posttranscriptional chemical modifications along its sequence. Read More

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http://dx.doi.org/10.1002/iub.2041DOI Listing
April 2019
1 Read

Association between LINC00657 and miR-106a serum expression levels and susceptibility to colorectal cancer, adenomatous polyposis, and ulcerative colitis in Egyptian population.

IUBMB Life 2019 Mar 29. Epub 2019 Mar 29.

Department of Medical Oncology, National Cancer Institute, Cairo University, Giza, Egypt.

Colorectal cancer (CRC) represented the second cause of mortality among cancer patients. Long noncoding RNAs and microRNAs (miRNAs) serve as noninvasive biomarkers for CRC surveillance and introduce new therapeutic approaches. LINC00657 and miR-106a expression levels play a pivotal role in CRC. Read More

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http://dx.doi.org/10.1002/iub.2039DOI Listing
March 2019
4 Reads
3.143 Impact Factor

Nimotuzumab inhibits epithelial-mesenchymal transition in prostate cancer by targeting the Akt/YB-1/AR axis.

IUBMB Life 2019 Mar 25. Epub 2019 Mar 25.

Department of Urology Surgery, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha 410002, People's Republic of China.

Nimotuzumab is a humanized anti-EGF monoclonal antibody that has been approved for treating different cancers. However, few studies have examined its therapeutic potential in prostate cancer (PC), a most common and highly aggressive malignancy among male population. We used both LNCaP, and PC3 and PC3-AR (androgen receptor) cells as the model system and assessed the effects of nimotuzumab on epithelial-mesenchymal transition (EMT) in vitro and in vivo. Read More

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http://dx.doi.org/10.1002/iub.2028DOI Listing

d-Amino Acid Modification Protects N-Acetyl-seryl-aspartyl-lysyl-proline from Physiological Hydroxylation and Increases Its Antifibrotic Effects on Hepatic Fibrosis.

IUBMB Life 2019 Mar 21. Epub 2019 Mar 21.

Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xian, China.

N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half-life in vivo greatly compromises its potential applications. Here, we report an Ac-SDKP analog peptide with d-amino acid replacement (Ac-SD K P). Read More

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http://dx.doi.org/10.1002/iub.2037DOI Listing
March 2019
2 Reads

Exenatide Ameliorates Inflammatory Response in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

IUBMB Life 2019 Mar 21. Epub 2019 Mar 21.

Department of Orthopedics, The first Affiliated Hospital of Soochow University, Suzhou, China.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology characterized by degradation of cartilage and bone, accompanied by unimpeded proliferation of synoviocytes of altered phenotype. In the present study, we investigated the involvement of the glucagon-like peptide 1 (GLP-1) receptor on human fibroblast-like synoviocytes (FLS) in the pathogenesis of RA using the selective GLP-1 agonist exenatide, a licensed drug used for the treatment of type 2 diabetes. Our results indicate that exenatide may play a role in regulating tumor necrosis factor-α-induced mitochondrial dysfunction by increasing mitochondrial membrane potential, oxidative stress by reducing the production of reactive oxygen species, the expression of NADPH oxidase 4, expression of matrix metalloproteinase (MMP)-3 and MMP-13, release of proinflammatory cytokines including interleukin-1β (IL-1β), IL-6, monocyte chemoattractant protein-1, and high-mobility group protein 1, as well as activation of the p38/nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, α/nuclear factor κB signaling pathway in primary human RA FLS. Read More

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http://dx.doi.org/10.1002/iub.2031DOI Listing
March 2019
2 Reads

Exosomal sphingosine 1-phosphate secreted by mesenchymal stem cells regulated Treg/Th17 balance in aplastic anemia.

IUBMB Life 2019 Mar 19. Epub 2019 Mar 19.

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

This study was designed to explore whether exosomal sphingosine 1-phosphate (S1P) from mesenchymal stem cells (MSCs) regulate the Treg/Th17 balance in aplastic anemia (AA) patients and to validate the underlying mechanism. To address this, exosomes from human bone marrow MSCs (MSCs-Exos) were co-cultured with CD4 T cells from AA patients (AA CD4 T cells), which were transfected with si-S1PR1, si-S1PR3, or not. The proportion of Th17 and Treg was evaluated by flow cytometry. Read More

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http://dx.doi.org/10.1002/iub.2035DOI Listing
March 2019
1 Read

Silence of Long Noncoding RNA NEAT1 Exerts Suppressive Effects on Immunity during Sepsis by Promoting MicroRNA-125-Dependent MCEMP1 Downregulation.

IUBMB Life 2019 Mar 18. Epub 2019 Mar 18.

Department of Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

Accumulating studies have recognized microRNAs (miRs) and long noncoding RNAs (lncRNAs) as important molecules involved in the mediation of various biological processes, including innate immunity. In this study, we investigated a novel noncoding RNA regulatory circuitry in the immunity during sepsis. A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). Read More

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http://dx.doi.org/10.1002/iub.2033DOI Listing

Association of a Genetic Variant in ATP-binding Cassette Sub-Family B Member 1 Gene with Poor Prognosis in Patients with Squamous Cell Carcinoma of the Esophagus.

IUBMB Life 2019 Mar 13. Epub 2019 Mar 13.

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Esophageal cancer is a common cause of death from cancer in men and the eighth most prevalent cancer globally. The morbidity and mortality rates are four times higher in men than in women. Genetic factors are among the susceptibility factors for squamous cell carcinoma of the esophagus. Read More

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http://dx.doi.org/10.1002/iub.2034DOI Listing
March 2019
1 Read

Molecular Characterization and Expression Profile of an Alternate Proliferating Cell Nuclear Antigen Homolog PbPCNA2 in Plasmodium berghei.

IUBMB Life 2019 Mar 13. Epub 2019 Mar 13.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.

Proliferative cell nuclear antigen (PCNA) is the processivity factor for various DNA polymerases and it functions in response to DNA damage in eukaryotic system. Plasmodium falciparum contains two PCNAs, while PCNA1 has been attributed to DNA replication, the role of PCNA2 has been assigned to DNA damage response in erythrocytic developmental stages. Although a recent transposon mediated knockout strategy qualified pcna2 as a nonessential gene in Plasmodium berghei, a conventional homologous recombination-based knockout strategy has not been employed for this gene yet. Read More

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http://dx.doi.org/10.1002/iub.2036DOI Listing
March 2019
2 Reads

Catalpol ameliorates advanced glycation end product-induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase.

IUBMB Life 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacology, School of Pharmacy, Hanlin College, Nanjing University of Chinese Medicine, Taizhou, People's Republic of China.

Catalpol (Cat.) is an iridoid glucoside extracted from the root of Rehmannia glutinosa Libosch. In this study, we investigated whether Cat. Read More

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http://dx.doi.org/10.1002/iub.2032DOI Listing

Decreased Expression of Long Noncoding RNA XLOC_013703 Promotes Cell Growth via NF-κB Pathway in Multiple Myeloma.

IUBMB Life 2019 Mar 12. Epub 2019 Mar 12.

Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.

Long noncoding RNAs (lncRNAs) are dysregulated in cancer and involved in oncogenic or tumor inhibitory processes. The aim of the study was to investigate the expression pattern of lncRNA XLOC_013703 in multiple myeloma (MM) and to evaluate its biological role and potential significance. We found that XLOC_013703 was significantly decreased in CD138 positive plasma cells and serum of MM patients compared to normal controls, and the decreased XLOC_013703 expression was correlated with β2-MG, serum-free light chain (s-FLC) and revised international staging system. Read More

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http://dx.doi.org/10.1002/iub.2029DOI Listing
March 2019
2 Reads

Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.

IUBMB Life 2019 Feb 28. Epub 2019 Feb 28.

Department of Thoracic Cardiovascular Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, China.

Kinesin family member 18A (KIF18A), as a member of the kinesin superfamily, is significantly overexpressed and abnormally functions in various human cancers. But, its expression profiling in the lung adenocarcinoma (LUAD) remains unclear. In the present work, using the data derived from the Cancer Genome Atlas (TCGA), we assessed the expression pattern and prognostic value of KIF18A in LUAD. Read More

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http://dx.doi.org/10.1002/iub.2030DOI Listing
February 2019
2 Reads

Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma development by epigenetically inhibiting PTEN via methyltransferase EZH2.

IUBMB Life 2019 Feb 27. Epub 2019 Feb 27.

Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan University, Zhengzhou, 450003, China.

Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mechanism of SOX2-OT in LSCC remains unclear. Read More

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http://dx.doi.org/10.1002/iub.2026DOI Listing
February 2019
2 Reads

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR-548d-3p to modulate JAK-STAT pathway in oral squamous cell carcinoma.

IUBMB Life 2019 Feb 26. Epub 2019 Feb 26.

Department of Stomatology, Zhejiang Hospital, Zhejiang, Hangzhou, China.

Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, however, its functional mechanism remains uncertain. Read More

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http://doi.wiley.com/10.1002/iub.2012
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http://dx.doi.org/10.1002/iub.2012DOI Listing
February 2019
4 Reads

Biochemical Properties and Oxalate-Degrading Activity of Oxalate Decarboxylase from Bacillus subtilis at Neutral pH.

IUBMB Life 2019 Feb 26. Epub 2019 Feb 26.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

Oxalate decarboxylase (OxDC) from Bacillus subtilis is a Mn-dependent hexameric enzyme that converts oxalate to carbon dioxide and formate. OxDC has greatly attracted the interest of the scientific community, mainly due to its biotechnological and medical applications in particular for the treatment of hyperoxaluria, a group of pathologic conditions caused by oxalate accumulation. The enzyme has an acidic optimum pH, but most of its applications involve processes occurring at neutral pH. Read More

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http://dx.doi.org/10.1002/iub.2027DOI Listing
February 2019
1 Read
3.143 Impact Factor

The significant others: Global search for direct kinase substrates using chemical approaches.

IUBMB Life 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry and Purdue University Center for Cancer Research, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.

Protein kinases function as key signaling hubs in the intricate network of biochemical signaling processes in the living cell. More than two-thirds of the human proteome is estimated to be phosphorylated at ~960,000 phosphosites, which makes it challenging to identify the direct contribution of any desired kinase in generating this phosphoproteome. In this review, we discuss some of the methods that have been developed over the years for global identification of kinase substrates. Read More

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http://dx.doi.org/10.1002/iub.2023DOI Listing
February 2019

Genetic association of DNMT variants can play a critical role in defining the methylation patterns in autism.

IUBMB Life 2019 Feb 20. Epub 2019 Feb 20.

Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediated by methylation patterns which are established and maintained by DNA methyltransferases. Read More

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http://dx.doi.org/10.1002/iub.2021DOI Listing
February 2019
1 Read

Vitamin E: Regulatory role in the cardiovascular system.

IUBMB Life 2019 Apr 18;71(4):507-515. Epub 2019 Feb 18.

Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, Istanbul, Turkey.

Cardiovascular disease (CVD) is one of the major causes of morbidity and mortality, all around the world. Vitamin E is an important nutrient influencing key cellular and molecular mechanisms as well as gene expression regulation centrally involved in the prevention of CVD. Cell culture and animal studies have focused on the identification of vitamin E regulated signaling pathways and involvement on inflammation, lipid homeostasis, and atherosclerotic plaque stability. Read More

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http://dx.doi.org/10.1002/iub.2020DOI Listing

Long noncoding RNA MALAT1 mediates high glucose-induced glomerular endothelial cell injury by epigenetically inhibiting klotho via methyltransferase G9a.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Several recent reporters have indicated the potential role of long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in diabetic nephropathy (DN). However, these studies mainly focus on renal tubular epithelial cells HK-2, the role of MALAT1 in human renal glomerular endothelial cells (HRGECs) remains unclear. Hence, this study aimed to explore the role of MALAT1 in high glucose (HG)-induced HRGECs injury and the underlying epigenetic mechanism. Read More

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http://dx.doi.org/10.1002/iub.2009DOI Listing
February 2019
2 Reads

Bioinformatic Analysis of Cacybp-Associated Proteins Using Human Glioma Databases.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Hematology, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu.

The ubiquitin-proteasome system is the primary cellular pathway for protein degradation, mediating 80% of intracellular protein degradation. Because of the widespread presence of ubiquitin-modified protein substrates, ubiquitination can regulate a variety of cellular activities including cell proliferation, apoptosis, autophagy, endocytosis, DNA damage repair, and immune responses. With the continuous generation of genomics data in recent years it has become particularly important to analyze these data effectively and reasonably. Read More

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http://dx.doi.org/10.1002/iub.1999DOI Listing
February 2019
1 Read

Mitochondrial Dysfunctions in Barth Syndrome.

IUBMB Life 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

Barth syndrome (BTHS) is a rare multisystemic genetic disorder caused by mutations in the TAZ gene. TAZ encodes a mitochondrial enzyme that remodels the acyl chain composition of newly synthesized cardiolipin, a phospholipid unique to mitochondrial membranes. The clinical abnormalities observed in BTHS patients are caused by perturbations in various mitochondrial functions that rely on remodeled cardiolipin. Read More

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http://dx.doi.org/10.1002/iub.2018DOI Listing
February 2019
2 Reads

MicroRNA-365 Promotes the Contractile Phenotype of Venous Smooth Muscle Cells and Inhibits Neointimal Formation in Rat Vein Grafts.

IUBMB Life 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiothoracic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

The high rate of autologous vein graft failure caused by neointimal hyperplasia remains an unresolved issue in the field of cardiovascular surgery; therefore, it is important to explore new methods for protecting against neointimal hyperplasia. MicroRNA-365 has been reported to inhibit the proliferation of vascular smooth muscle cells (SMCs). This study aimed to test whether adenovirus-mediated miR-365 was able to attenuate neointimal formation in rat vein grafts. Read More

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http://dx.doi.org/10.1002/iub.2022DOI Listing
February 2019
1 Read

IUBMB-Life 2019: Vitamin E-Regulatory Roles.

Authors:
Jean-Marc Zingg

IUBMB Life 2019 Apr 11;71(4):409-410. Epub 2019 Feb 11.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.2017DOI Listing
April 2019
1 Read

Preptin Promotes Proliferation and Osteogenesis of MC3T3-E1 Cells by Upregulating β-Catenin Expression.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Rheumatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Preptin, an oligopeptide secreted by pancreatic β-cell, plays a significant role in glycometabolism and bone metabolism. Preptin strengthens proliferation and differentiation of osteoblasts, but the mechanism is unclear. Here, we explored the role of the Wnt/β-catenin signaling pathway which is well known to affect bone development and remodelling in the function of preptin. Read More

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http://dx.doi.org/10.1002/iub.2016DOI Listing
February 2019
2 Reads
3.143 Impact Factor

Therapeutic potential of toll-like receptors in treatment of gynecological cancers.

IUBMB Life 2019 May 6;71(5):549-564. Epub 2019 Feb 6.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Toll-like receptors (TLRs) play an important role in the innate and adaptive immune system. They are expressed in various regions of the female reproductive tract, and their regulation may be involved in the pathogenesis of gynecological lesions. There is growing evidence that ligands for several TLRs are potentially anticancer agents, some of which have already been approved by the FDA, and these compounds are now undergoing clinical evaluation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2011
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http://dx.doi.org/10.1002/iub.2011DOI Listing
May 2019
6 Reads

T cell engineered with a novel nanobody-based chimeric antigen receptor against VEGFR2 as a candidate for tumor immunotherapy.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Immunology, Hybridoma Lab, Pasteur Institute of Iran, Tehran, Iran.

Solid tumors that are responsible for more than 85% of cancer death cases need angiogenesis for their growth and metastasis. Among antiangiogenic therapies, targeting the vascular endothelial growth factor receptor 2 (VEGFR2) that is over-expressed on tumor vasculatures has been a promising strategy. In this study, we developed a second generation nanobody (VHH)-based CAR T cell targeting VEGFR2-expressing tumor cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2019
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http://dx.doi.org/10.1002/iub.2019DOI Listing
February 2019
13 Reads
3.143 Impact Factor

Serum Exosomal microRNA Let-7i-3p as Candidate Diagnostic Biomarker for Kawasaki Disease Patients with Coronary Artery Aneurysm.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Biological Resource Bank, Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Kawasaki disease (KD) is a systemic vasculitis syndrome that leads to coronary artery aneurysm (CAA). While echocardiography is the most important imaging modality for coronary artery assessment, a specific diagnostic biomarker complementary for CAA has not been reported. We aimed to analyze the profiles of exosomal miRNAs extracted from the serum of KD patients and controls to identify candidate biomarkers for CAA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2015
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http://dx.doi.org/10.1002/iub.2015DOI Listing
February 2019
15 Reads
3.143 Impact Factor

3,5-diiodo-L-thyronine increases de novo lipogenesis in liver from hypothyroid rats by SREBP-1 and ChREBP-mediated transcriptional mechanisms.

IUBMB Life 2019 Feb 1. Epub 2019 Feb 1.

Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100, Lecce, Italy.

Hepatic de novo lipogenesis (DNL), the process by which carbohydrates are converted into lipids, is strictly controlled by nutritional and hormonal status. 3,5-Diiodo-L-thyronine (T2), a product of the 3,5,3'-triiodo-L-thyronine (T3) peripheral metabolism, has been shown to mimic some T3 effects on lipid metabolism by a short-term mechanism independent of protein synthesis. Here, we report that T2, administered for 1 week to hypothyroid rats, increases total fatty acid synthesis from acetate in isolated hepatocytes. Read More

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http://dx.doi.org/10.1002/iub.2014DOI Listing
February 2019
2 Reads

The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug.

IUBMB Life 2019 May 14;71(5):532-538. Epub 2019 Jan 14.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

The observations that the innate immune system employs copper to eliminate bacterial infection and that resistance to copper enhances virulence of Mycobacterium tuberculosis (Mtb) prompted us to examine the effects the anti-cancer agent elesclomol on Mtb. As a bis-thionohydrazide, elesclomol chelates with copper to form a copper complex in situ that via redox cycling of the metal ion greatly enhances oxidative stress in tumour cells. Here, we demonstrate that elesclomol is relatively potent against Mtb H37Rv with minimum inhibitory concentration of 10 μM (4 mg/L) and against multidrug resistant clinical isolates of Mtb, displays additive interactions with known tuberculosis drugs such as isoniazid and ethambutol, and a synergistic interaction with rifampicin. Read More

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http://dx.doi.org/10.1002/iub.2002DOI Listing
May 2019
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Hydroxycamptothecin Prevents Fibrotic Pathways in Fibroblasts In Vitro.

IUBMB Life 2019 May 28;71(5):653-662. Epub 2019 Jan 28.

Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Peritendinous fibrosis, which leads to impaired tendon function, is a clinical problem worldwide, and it is urgent to explore potential ways to reduce the formation of peritendinous adhesion. Several studies have demonstrated the biological roles of hydroxycamptothecin (HCPT) in inhibiting fibrosis in different tissues. In this study, we investigated whether HCPT could inhibit tendon fibrosis in vitro. Read More

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http://dx.doi.org/10.1002/iub.2013DOI Listing

Vitamin E: Regulatory Redox Interactions.

IUBMB Life 2019 Apr 25;71(4):430-441. Epub 2019 Jan 25.

Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.

Vitamin E is an essential nutrient that was discovered in the 1920s. Many of the physiological functions of vitamin E, including its antioxidative effects, have been studied for nearly 100 years. Changes in redox balance induced by both endogenously and exogenously generated reactive oxygen species (ROS) are involved in various diseases, and are also a phenomenon that is considered essential for survival. Read More

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http://dx.doi.org/10.1002/iub.2008DOI Listing

Ameliorating the antimicrobial resistance crisis: phage therapy.

IUBMB Life 2019 Jan 23. Epub 2019 Jan 23.

Department of Biology, Indian Institute of Science Education and Research, Tirupati, India.

Propelled by the overuse and inappropriate use of antibiotics, antimicrobial resistance is now widespread in the environment, leaving us with limited drugs for treating a large number of resistant pathogens. The use of bacteriophages that kill bacteria has come up as a viable alternative to circumvent the antimicrobial resistance crisis, and phage therapy-based approaches are fast advancing in recent times. In this minireview, we try to describe the advantages associated with phage therapy and update the latest developments in the field including the clinical trials that are underway. Read More

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http://dx.doi.org/10.1002/iub.2010DOI Listing
January 2019

The tumour suppressing role of the circadian clock.

IUBMB Life 2019 Jan 23. Epub 2019 Jan 23.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

The circadian clock and the ~24 h rhythms it generates are essential in maintaining regular tissue functioning. At the molecular level, the circadian clock comprises a core set of rhythmically expressed genes and gene products that are able to drive rhythmic expression of other genes to generate overt circadian rhythms. It has recently come to light that perturbations of circadian rhythms contribute to the development of pathological states such as cancer, and altered expression and/or regulation of circadian clock genes has been identified in multiple tumour types. Read More

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http://dx.doi.org/10.1002/iub.2005DOI Listing
January 2019

Transplacental Delivery of Genome Editing Components Causes Mutations in Embryonic Cardiomyocytes of Mid-Gestational Murine Fetuses.

IUBMB Life 2019 Jan 11. Epub 2019 Jan 11.

Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima, Kagoshima, 890-8544, Japan.

Genome editing, as exemplified by CRISPR/Cas9, is now recognized as a powerful tool for the engineering of endogenous target genes. It employs only two components, namely, Cas9 in the form of DNA, mRNA, or protein; and guide RNA (gRNA), which is specific to a target gene. When these components are transferred to cells, they create insertion/deletion mutations (indels) within a target gene. Read More

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http://doi.wiley.com/10.1002/iub.2004
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http://dx.doi.org/10.1002/iub.2004DOI Listing
January 2019
13 Reads

Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles.

IUBMB Life 2019 Apr 11;71(4):442-455. Epub 2019 Jan 11.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Read More

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http://doi.wiley.com/10.1002/iub.2003
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http://dx.doi.org/10.1002/iub.2003DOI Listing
April 2019
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Nutritional evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae.

IUBMB Life 2019 Jan 10. Epub 2019 Jan 10.

Ligno Biotech Sdn. Bhd., Seri Kembangan, Selangor, Malaysia.

Sclerotial powder of a cultivated species of the Tiger Milk Mushroom, Lignosus cameronensis was analysed for its nutritional components and compared against species of the same genus, Lignosus rhinocerus and Lignosus tigris. All three species have been used by indigenous tribes in Peninsular Malaysia as medicinal mushrooms. Content of carbohydrate, fibre, mineral, amino acid, palatable index, fat, ash and moisture were determined. Read More

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http://doi.wiley.com/10.1002/iub.2006
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http://dx.doi.org/10.1002/iub.2006DOI Listing
January 2019
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LncRNA MIAT Facilitates Osteosarcoma Progression by Regulating miR-128-3p/VEGFC Axis.

IUBMB Life 2019 Jan 10. Epub 2019 Jan 10.

School of Life Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.

The aberrant expression of long non-coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction-associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. Read More

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http://dx.doi.org/10.1002/iub.2001DOI Listing
January 2019
2 Reads

The "great" controlling nucleotide coenzymes.

IUBMB Life 2019 May 9;71(5):565-579. Epub 2019 Jan 9.

Department of Biomedical Sciences, East Tennessee State University College of Medicine, Johnson City, TN, USA.

Nucleotide coenzymes dot the map of metabolic pathways providing energy to drive the reactions of the pathway and play an important role in regulating and controlling energy metabolism through their shared potential energy, which is widely unobserved due to the paradox that the energy in the coenzyme pools cannot be determined from the concentration of the coenzyme couples. The potential energy of the nucleotide couples in the mitochondria or the cytoplasm is expressed in the enzyme reactions in which they take part. The energy in these couples, [NAD+]/[NADH], [NADP+]/[NADPH], [acetyl CoA]/[CoA], and [ATP]/[ADP]x[Pi], regulates energy metabolism. Read More

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http://doi.wiley.com/10.1002/iub.1997
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http://dx.doi.org/10.1002/iub.1997DOI Listing
May 2019
13 Reads

Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism.

IUBMB Life 2019 May 7;71(5):643-652. Epub 2019 Jan 7.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.

Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association. The absence of structures involving competent enzymes bound to substrate/products came in the way of the precise elucidation of the catalytic mechanism of this family of proteins. Crystal structures of the enzyme from Mycobacterium tuberculosis in an unliganded form and its complex with the substrate/products have now been determined at 2. Read More

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http://dx.doi.org/10.1002/iub.2000DOI Listing
May 2019
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RING finger protein 10 attenuates vascular restenosis by inhibiting vascular smooth muscle cell hyperproliferation in vivo and vitro.

IUBMB Life 2019 May 30;71(5):632-642. Epub 2018 Dec 30.

Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Vascular smooth muscle cell (VSMC) hyperproliferation is the main pathological process in various cardiovascular diseases, such as vascular restenosis. This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Read More

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http://dx.doi.org/10.1002/iub.1995DOI Listing
May 2019
11 Reads

LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation.

IUBMB Life 2019 May 28;71(5):611-618. Epub 2018 Dec 28.

Department of the Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Long noncoding RNAs (LncRNAs) may serve as miRNA sponges to regulate the expressions of miRNA target genes. LncRNA LINC00969 has been indicated to be upregulated in intervertebral disk degeneration. However, the regulatory mechanism of LINC00969 in intervertebral disk degeneration progression remains unclear. Read More

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http://dx.doi.org/10.1002/iub.1989DOI Listing
May 2019
1 Read