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Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

Revisiting SEPT7 and the slippage of β-strands in the septin family.

J Struct Biol 2019 Apr 19. Epub 2019 Apr 19.

São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil. Electronic address:

Septins are GTP-binding proteins that will often spontaneously assemble into filaments. In some species, particularly budding yeast, it is well known that these are capable of associating with membranes in order to fulfill their cellular role as a component of the cytoskeleton. Different from other human septins, SEPT7 appears to be unique in that it is an essential component of all hetero-oligomeric complexes described to date. Read More

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http://dx.doi.org/10.1016/j.jsb.2019.04.015DOI Listing

The influence of image masking on object representations during rapid serial visual presentation.

Neuroimage 2019 Apr 19. Epub 2019 Apr 19.

School of Psychology, University of Sydney, NSW, 2006, Australia; ARC Centre of Excellence in Cognition and Its Disorders, NSW, 2109, Australia.

Rapid image presentations combined with time-resolved multivariate analysis methods of EEG or MEG (rapid-MVPA) offer unique potential in assessing the temporal limitations of the human visual system. Recent work has shown that multiple visual objects presented sequentially can be simultaneously decoded from M/EEG recordings. Interestingly, object representations reached higher stages of processing for slower image presentation rates compared to fast rates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193033
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http://dx.doi.org/10.1016/j.neuroimage.2019.04.050DOI Listing
April 2019
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Measuring Thought-Control Failure: Sensory Mechanisms and Individual Differences.

Psychol Sci 2019 Apr 22:956797619837204. Epub 2019 Apr 22.

1 School of Psychology, University of New South Wales.

The ability to control one's thoughts is crucial for attention, focus, ideation, and mental well-being. Although there is a long history of research into thought control, the inherent subjectivity of thoughts has made objective examination, and thus mechanistic understanding, difficult. Here, we report a novel method to objectively investigate thought-control success and failure by measuring the sensory strength of visual thoughts using binocular rivalry, a perceptual illusion. Read More

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http://dx.doi.org/10.1177/0956797619837204DOI Listing

The Role of Exopolysaccharides in Oral Biofilms.

J Dent Res 2019 Apr 22:22034519845001. Epub 2019 Apr 22.

1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.

The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and maintenance, and pathogenesis. Read More

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http://dx.doi.org/10.1177/0022034519845001DOI Listing

Attitudes towards Oral Health in Patients with Rheumatoid Arthritis: A Qualitative Study Nested within a Randomized Controlled Trial.

JDR Clin Trans Res 2019 Apr 22:2380084419833694. Epub 2019 Apr 22.

1 Periodontal Research Group, School of Dentistry, Institute of Clinical Sciences, University of Birmingham, and Birmingham Dental Hospital (Birmingham Community Healthcare NHS Foundation Trust), Edgbaston, Birmingham, UK.

Introduction: Patients with rheumatoid arthritis (RA) present a higher incidence and severity of periodontitis than the general population. Our study, Outcomes of Periodontal Treatment in Patients with Rheumatoid Arthritis (OPERA), was a randomized waiting-list controlled trial using mixed methods. Patients randomized to the intervention arm received intensive periodontal treatment, and those in the control arm received the same treatment with a 6-mo delay. Read More

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http://dx.doi.org/10.1177/2380084419833694DOI Listing

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection.

PLoS Pathog 2019 Apr 22;15(4):e1007653. Epub 2019 Apr 22.

Department of Microbiology and Immunology; University of Michigan Medical School; Ann Arbor, MI, United States of America.

The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in the urinary tract, little is known about pathogenesis in the bloodstream. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007653DOI Listing

Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.

PLoS One 2019 22;14(4):e0215504. Epub 2019 Apr 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

Inorganic arsenic is an environmental human carcinogen of several organs including the urinary tract. RWPE-1 cells are immortalized, non-tumorigenic, human prostate epithelia that become malignantly transformed into the CAsE-PE line after continuous in vitro exposure to 5μM arsenite over a period of months. For insight into in vitro arsenite transformation, we performed RNA-seq for differential gene expression and targeted sequencing of KRAS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215504PLOS

Per-Pass Analysis of Thrombus Composition in Patients With Acute Ischemic Stroke Undergoing Mechanical Thrombectomy.

Stroke 2019 May;50(5):1156-1163

Cerenovus, Galway Neuro Technology Centre, Ireland (S.D., R.M., M.G.).

Background and Purpose- Mechanical thrombectomy may involve multiple attempts to retrieve the occluding thrombus. This study examined the composition of thrombus fragments retrieved with each pass of a device during the thrombectomy procedure. Second, the per-pass composition was compared with procedural and clinical data including angiographic outcome and stroke etiology. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023419
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http://dx.doi.org/10.1161/STROKEAHA.118.023419DOI Listing
May 2019
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Monitoring the Curriculum through the Student Perspective.

J Vet Med Educ 2019 Apr 22:1-16. Epub 2019 Apr 22.

Student input was deliberately included as part of the curriculum implementation and assessment plan at the University of Minnesota College of Veterinary Medicine. The new curriculum included design features to encourage deeper learning such as a spiral curriculum with cross-course integration, increased open time, and more active learning. Student well-being was seen as a simultaneous need. Read More

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http://dx.doi.org/10.3138/jvme.0418-038r1DOI Listing

Deficits in Quadriceps Force Control After Anterior Cruciate Ligament Injury: Potential Central Mechanisms.

J Athl Train 2019 Apr 22. Epub 2019 Apr 22.

Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia.

Context: Poor quadriceps force control has been observed after anterior cruciate ligament (ACL) reconstruction but has not been examined after ACL injury. Whether adaptations within the central nervous system are contributing to these impairments is unknown.

Objective: To examine quadriceps force control in individuals who had sustained a recent ACL injury and determine the associations between cortical excitability and quadriceps force control in these individuals. Read More

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http://dx.doi.org/10.4085/1062-6050-414-17DOI Listing

Profiling Commenters on Mental Health-Related Online Forums: A Methodological Example Focusing on Eating Disorder-Related Commenters.

JMIR Ment Health 2019 Apr 22;6(4):e12555. Epub 2019 Apr 22.

Warwick Manufacturing Group, University of Warwick, Coventry, United Kingdom.

Background: Understanding the characteristics of commenters on mental health-related online forums is vital for the development of effective psychological interventions in these communities. The way in which commenters interact can enhance our understanding of their characteristics.

Objective: Using eating disorder-related (EDR) forums as an example, this study detailed a methodology that aimed to determine subtypes of mental health-related forums and profile their commenters based on the other forums to which they contributed. Read More

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http://dx.doi.org/10.2196/12555DOI Listing

Understanding cerebellum in vertebrate neuroethology: From sensing in sharks and electric fish to motor sequences in movement and birdsong.

Behav Neurosci 2019 Apr 22. Epub 2019 Apr 22.

Department of Neuroscience and Zuckerman Institute, Columbia University.

The elaborate structure of the cerebellum has been long known, although its contribution to a remarkable diversity of behavior is only recently appreciated. Taking an evolutionary perspective, we consider the wider function of the cerebellum based on insight from the function of so-called cerebellum-like structures. Cerebellum-like structures cancel the effects of self-stimulation, a function that has been well characterized in both elasmobranch and weakly electric fish. Read More

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http://dx.doi.org/10.1037/bne0000317DOI Listing

Probing Anisotropic Surface Properties of Illite by Atomic Force Microscopy.

Langmuir 2019 Apr 22. Epub 2019 Apr 22.

For the purpose of understanding the colloidal behaviors of illite in mineral processing, probing the surface charging property of illite is of great significance. This research explored the edge and basal surfaces of illite using an atomic force microscope (AFM). The interaction forces between Si/Si3N4 probes and illite edge/basal surfaces were measured, respectively, at different pH values in 10 mM KCl solutions. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00270DOI Listing

Medical and information needs among young women with breast cancer in Mexico.

Eur J Cancer Care (Engl) 2019 Apr 22:e13040. Epub 2019 Apr 22.

Joven & Fuerte: Program for the Care and Research of Young Women with Breast Cancer in Mexico, Mexico City, Mexico.

Objective: To describe clinical and information needs, identify unmet support services and guide interventions for young breast cancer (BC) patients in Mexico.

Methods: Cross-sectional, qualitative study, using interpretive description methodology. Patients with initial BC diagnosis within 6-12 months prior to enrolment, ≤40 years old and literate were included in focus groups. Read More

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http://dx.doi.org/10.1111/ecc.13040DOI Listing

[Research advances of autonomic nervous system in the regulation of cardiac inflammation].

Sheng Li Xue Bao 2019 Apr;71(2):225-234

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

The autonomic nervous system consists of the sympathetic nervous system and the parasympathetic nervous system. These two systems control the heart and work in a reciprocal fashion to modulate myocardial energy metabolism, heart rate as well as blood pressure. Multiple cardiac pathological conditions are accompanied by autonomic imbalance, characterized by sympathetic overactivation and parasympathetic inhibition. Read More

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Self-assessment of executive function and lateralization of brain pathology: What does the DEX-S profile show?

Psychiatr Pol 2019 Feb 28;53(1):129-143. Epub 2019 Feb 28.

Wojewódzki Szpital Specjalistyczny, Biała Podlaska.

Objectives: The DEX-S Questionnaire is a tool often used in the self-report of executive difficulties. Numerous data demonstrate that the result of the DEX-S do not differentiate between healthy and clinical groups or people with different characteristics of brain pathology. Limited research taking into account lateralization of damage also did not provide the conclusive data. Read More

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http://dx.doi.org/10.12740/PP/OnlineFirst/85936DOI Listing
February 2019

Differences in subjective quality of life of people with a schizophrenia diagnosis between participants in Occupational Therapy Workshops and those working in a Sheltered Employment Establishment.

Psychiatr Pol 2019 Feb 28;53(1):81-92. Epub 2019 Feb 28.

Uniwersytet Jagielloński Collegium Medicum, Katedra Psychiatrii, Zakład Psychiatrii Środowiskowej.

Objectives: The research objective was to compare the course of illness among patients with schizophrenia undergoing rehabilitation in Occupational Therapy Workshops (OTW) or employed in the Vocational Development Center "Pensjonat u Pana Cogito" (VDC), with particular focus on quality of life (QoL), and to analyse the relations between QoL and general, social, and cognitive functioning, psychopathological condition and insight in the two groups.

Methods: The sample comprised 52 subjects (VDC = 25 and OT = 27). The following tools were used: the LQoLP (for quality of life assessment) by Oliver, the PANSS, GAF, and SOFAS scales, the MoCA, RAVLT and RHLB cognitive tests, and the insight questionnaire "My thoughts and feelings". Read More

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http://dx.doi.org/10.12740/PP/91915DOI Listing
February 2019

Occupational burnout and lifestyle in Kazakhstan cardiologists.

Arch Public Health 2019 10;77:13. Epub 2019 Apr 10.

1Al-Fabari Kazakh National University, al-Farabi avenue 71, Almaty, Kazakhstan 050040.

Background: No data exist in the published literature on burnout in physicians from Central Asia. The aim of this analysis was to assess burnout prevalence in doctors and nurses of a cardiological hospital in Almaty, Kazakhstan and ascertain whether smoking, alcohol and physical activity may predict job-associated burnout.

Methods: The staff of the City Cardiological Centre of Almaty ( = 259, 82% females) filled in the questionnaire with the questions on demographics, lifestyle, including smoking, alcohol and physical activity, as well as fatigue (using Fatigue Severity Scale (FSS)) and burnout using Maslach Burnout Inventory (MBI) Human Services Survey for Medical Personnel. Read More

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http://dx.doi.org/10.1186/s13690-019-0345-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457002PMC

Informed Consent in Biomedical Research.

Comput Struct Biotechnol J 2019 25;17:463-474. Epub 2019 Mar 25.

Independent Scientist, Ottawa, Canada.

Informed consent is the result of tumultuous events in both the clinical and research arenas over the last 100 years. Throughout this time, the notion of informed consent has shifted tremendously, both due to advances in medicine, as well as the type of data being gathered. As such, informed consent has misaligned with the goals of medical research. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458444PMC

THE FOURIER RADIAL ERROR SPECTRUM PLOT: A MORE NUANCED QUANTITATIVE EVALUATION OF IMAGE RECONSTRUCTION QUALITY.

Proc IEEE Int Symp Biomed Imaging 2018 Apr 24;2018:61-64. Epub 2018 May 24.

Signal and Image Processing Institute, University of Southern California, Los Angeles, CA 90089.

In the modern biomedical image reconstruction literature, the quality of a reconstructed image is often numerically quantified using scalar error measures such as mean-squared error or the structural similarity index. While such measures provide a rough summary of image quality, they also suffer from well-known limitations. For example, a substantial amount of information is necessarily lost whenever the characteristics of a high-dimensional image are summarized by a single number. Read More

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http://dx.doi.org/10.1109/ISBI.2018.8363523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472927PMC

Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4.

Cancer Cell Int 2019 11;19:94. Epub 2019 Apr 11.

Department of Gastroenterology, Jiangxi Pingxiang People's Hospital, No. 8, Wugongshan Middle Road, Pingxiang, 337000 Jiangxi People's Republic of China.

Background: In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppressors in cancers. Therefore, we investigated the effect of LINC01314 on the development of GC cells in relation to the Wnt/β-catenin signaling pathway. Read More

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http://dx.doi.org/10.1186/s12935-019-0799-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458728PMC

Social networks, mobility, and political participation: The potential for women's self-help groups to improve access and use of public entitlement schemes in India.

World Dev 2019 Feb;114:28-41

International Food Policy Research Institute, Washington, DC, United States.

Women's self-help groups (SHGs) have increasingly been used as a vehicle for social, political, and economic empowerment as well as a platform for service delivery. Although a growing body of literature shows evidence of positive impacts of SHGs on various measures of empowerment, our understanding of ways in which SHGs improve awareness and use of public services is limited. To fill this knowledge gap, this paper first examines how SHG membership is associated with political participation, awareness, and use of government entitlement schemes. Read More

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http://dx.doi.org/10.1016/j.worlddev.2018.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472676PMC
February 2019

Sensitivity Kernels of PP Precursor Traveltimes and Their Limitations for Imaging Topography of Discontinuities.

Geophys Res Lett 2019 Jan 23;46(2):698-707. Epub 2019 Jan 23.

Department of Earth Sciences Universiteit Utrecht Utrecht The Netherlands.

We analyze the sensitivity of PP precursor traveltimes that are often used to infer lateral variation in the depths of the 410- and 660-km discontinuities in the mantle. Previous results were inconclusive due to complex wave phenomena, such as multiple energy conversions and focusing/defocusing, that hamper their interpretation. Using spectral-element synthetics and Fréchet derivatives calculated with adjoint methods, we compute sensitivity kernels for volumetric and boundary parameters in a 1-D model for representative epicentral distances of past studies, and a dominant period of 11-25 s. Read More

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http://dx.doi.org/10.1029/2018GL081592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472573PMC
January 2019

Wearing the Mask of Wellness: The Experience of Young Women Living With Advanced Breast Cancer.

Oncol Nurs Forum 2019 May;46(3):329-337

Boston College.

Purpose: To describe and interpret the lived experiences of young women with advanced breast cancer.

Participants & Setting: 12 women, aged 25-39 years with advanced breast cancer, were recruited from private Facebook groups for women with breast cancer.

Methodologic Approach: Van Manen's hermeneutic phenomenologic method was used. Read More

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http://dx.doi.org/10.1188/19.ONF.329-337DOI Listing

Quorum sensing pathways in Gram-positive and -negative bacteria: potential of their interruption in abating drug resistance.

J Chemother 2019 Apr 22:1-27. Epub 2019 Apr 22.

a Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University , Jazan , Saudi Arabia.

Quorum sensing (QS) is an inter-cell communication between bacterial populations through release of tiny diffusible compounds as signalling agents, called auto-inducers, abetting bacteria to track population density. QS allows bacterial population to perform collectively in coordination to wide phenotypes like alterations in expression of virulence genes to achieve advancement over their competitors, drug resistance and biofilm formation. Several classes of autoinducers have been described that are involved in bacterial virulence. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1599175DOI Listing

"A Mile in Her Shoes": A qualitative exploration of the perceived benefits of volunteer led running groups for homeless women.

Health Soc Care Community 2019 Apr 21. Epub 2019 Apr 21.

Faculty of Health, Social Care and Education, a joint faculty between Kingston University and St George's, University of London, London, United Kingdom.

"A Mile in Her Shoes" is a volunteer-led charity which provides running groups for homeless women. The objective of this study was to explore the experiences of homeless women attending these running groups and to establish how participation in a supported running group impacted their lives. This exploratory qualitative study was carried out across two sites in London UK during February and April 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hsc.12755
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http://dx.doi.org/10.1111/hsc.12755DOI Listing
April 2019
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Neuroimaging in alcohol use disorder: From mouse to man.

J Neurosci Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.

This article provides an overview of recent advances in understanding the effects of alcohol use disorders (AUD) on the brain from the perspective of magnetic resonance imaging (MRI) research in preclinical models and clinical studies. As a noninvasive investigational tool permitting assessment of morphological, metabolic, and hemodynamic changes over time, MRI offers insight into the dynamic course of alcoholism beginning with initial exposure through periods of binge drinking and escalation, sobriety, and relapse and has been useful in differential diagnosis of neurological diseases associated with AUD. Structural MRI has revealed acute and chronic effects of alcohol on both white and gray matter volumes. Read More

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http://dx.doi.org/10.1002/jnr.24423DOI Listing

[An organic mental disorder and comorbid affective spectrum disturbances: a forensic-psychiatric assessment].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):39-44

Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Health of RF, Moscow, Russia.

Aim: To identify the influence of combined pathology, an organic personality disorder and affective disturbances, on the regulation of subjects' legally significant behavior in forensic-psychiatric examination in criminal and civil proceedings.

Material And Methods: Two groups of patients with the diagnosis of organic personality disorder (ICD-10 F07) established in the course of forensic-psychiatric examination were studied. The first group included 82 criminally prosecuted men (mean age 40. Read More

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http://dx.doi.org/10.17116/jnevro20191191239DOI Listing
January 2019

Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells.

Stem Cell Reports 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

Leveraging the extraordinary potential of human pluripotent stem cells (hPSCs) requires an understanding of the mechanisms underlying cell-fate decisions. Substrate elasticity can induce differentiation by signaling through the transcriptional coactivator Yes-associated protein (YAP). Cells cultured on surfaces mimicking brain elasticity exclude YAP from their nuclei and differentiate to neurons. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22136711193009
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http://dx.doi.org/10.1016/j.stemcr.2019.03.009DOI Listing
April 2019
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Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast.

Curr Biol 2019 Apr 12. Epub 2019 Apr 12.

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address:

For proper chromosome segregation in mitosis, sister kinetochores must interact with microtubules from opposite spindle poles (chromosome bi-orientation) [1, 2]. To promote bi-orientation, Aurora B kinase disrupts aberrant kinetochore-microtubule interactions [3-6]. It has long been debated how Aurora B halts this action when bi-orientation is established and tension is applied across sister kinetochores. Read More

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http://dx.doi.org/10.1016/j.cub.2019.03.051DOI Listing

Density artefacts at interfaces caused by multiple time-step effects in molecular dynamics simulations.

F1000Res 2018 5;7:1745. Epub 2018 Nov 5.

Laboratory of Physical Chemistry, ETH Zürich, Zurich, 8093, Switzerland.

Molecular dynamics (MD) simulations have become an important tool to provide insight into molecular processes involving biomolecules such as proteins, DNA, carbohydrates and membranes. As these processes cover a wide range of time scales, multiple time-step integration methods are often employed to increase the speed of MD simulations. For example, in the twin-range (TR) scheme, the nonbonded forces within the long-range cutoff are split into a short-range contribution updated every time step (inner time step) and a less frequently updated mid-range contribution (outer time step). Read More

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http://dx.doi.org/10.12688/f1000research.16715.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441880.3PMC
November 2018

Oral premalignant lesions of smokers and non-smokers show similar carcinogenic pathways and outcomes. A clinicopathological and molecular comparative analysis.

J Oral Pathol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Pathology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain.

Background: Oral premalignant lesions (OPML) are frequently extensive and multifocal leading high morbidity for patients. Although oral squamous carcinoma (OSCC) in non-smoker patients is increasing, little is known about OPML and the carcinogenesis process in these patients. The aims of the study were to insight and compare the clinicopathological and molecular characteristics of OPML of non-smoker and smoker patients from which one or multiple OSCC have developed. Read More

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http://dx.doi.org/10.1111/jop.12864DOI Listing

Altitudinal gradients fail to predict fungal symbiont responses to warming.

Ecology 2019 Apr 21:e02740. Epub 2019 Apr 21.

Department of Biology, The University of New Mexico, Albuquerque, New Mexico, 87131, USA.

Climate change is shifting altitudinal species ranges, with potential to disrupt species interactions. Altitudinal gradient studies and warming experiments can both increase understanding of climate effects on species interactions, but few studies have used both together to improve predictions. We examined whether plant-fungal symbioses responded similarly to altitude and 23 years of experimental warming. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ecy.2740
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http://dx.doi.org/10.1002/ecy.2740DOI Listing
April 2019
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Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis.

J Neurochem 2019 Apr 21. Epub 2019 Apr 21.

Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

The gut microbiota is increasingly recognized to modulate brain function by recent studies demonstrating the central effects of various gut microbial manipulation strategies. Our previous study demonstrated that antibiotics-induced alterations of hindgut microbiota are associated with changes in aromatic amino acid (AAA) metabolism and hypothalamic neurochemistry, while the underlying mechanism insight is limited. Given that the microbial AAA metabolism can be affected by luminal carbohydrate availability, here we hypothesize that increasing hindgut carbohydrate availability affects the expression of neurotransmitters in the porcine hypothalamus. Read More

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http://dx.doi.org/10.1111/jnc.14709DOI Listing

Neurite orientation dispersion and density imaging of mouse brain microstructure.

Brain Struct Funct 2019 Apr 20. Epub 2019 Apr 20.

Center for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA.

Advanced biophysical models like neurite orientation dispersion and density imaging (NODDI) have been developed to estimate the microstructural complexity of voxels enriched in dendrites and axons for both in vivo and ex vivo studies. NODDI metrics derived from high spatial and angular resolution diffusion MRI using the fixed mouse brain as a reference template have not yet been reported due in part to the extremely long scan time required. In this study, we modified the three-dimensional diffusion-weighted spin-echo pulse sequence for multi-shell and undersampling acquisition to reduce the scan time. Read More

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http://dx.doi.org/10.1007/s00429-019-01877-xDOI Listing

NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression.

Cell Mol Life Sci 2019 Apr 20. Epub 2019 Apr 20.

School of Life Sciences, Tsinghua University, Beijing, 100084, China.

The accumulation of intracellular β-amyloid peptide (Aβ) is important pathological characteristic of Alzheimer's disease (AD). However, the exact underlying molecular mechanism remains to be elucidated. Here, we reported that Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), a long n on-coding RNA, exhibits repressed expression in the early stage of AD and its down-regulation declines neuroglial cell mediating Aβ clearance via inhibiting expression of endocytosis-related genes. Read More

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http://dx.doi.org/10.1007/s00018-019-03074-9DOI Listing

Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways†.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Surgery, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Objectives: Thoracic endovascular techniques for aneurysm repair offer less invasive alternatives to open strategies. Both approaches, however, are associated with the risk for neurological complications. Despite adjuncts to maintain spinal cord perfusion, ischaemia and paraplegia continue to occur during thoracoabdominal aortic aneurysm (TAAA) repair. Read More

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http://dx.doi.org/10.1093/ejcts/ezz113DOI Listing

New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Monell Chemical Senses Center, Philadelphia, PA.

Background: Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption of sweet substances remains unclear.

Objective: The aim of this study was to verify previous reported associations within genes involved in the peripheral receptor systems (i.e. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz043DOI Listing
April 2019
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Probing the binding interaction of zinc and cadmium with garlic phytocystatin: Implication of the abiotic stress on garlic phytocystatin.

Int J Biol Macromol 2019 Apr 18. Epub 2019 Apr 18.

Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India. Electronic address:

Abiotic stress induced by heavy metals retards the growth and development of plants. Therefore, it is essential to have an insight into the potential toxic effects of heavy metals. The present article investigates the effect of zinc and cadmium on the structure and function of garlic phytocystatin (GPhyCys). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.036DOI Listing

Managing and Preventing Vascular Catheter Infections ISID Position Paper.

Int J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

VCU Medical Center, Richmond, VA, USA.

A panel of experts was convened by the International Society for Infectious Diseases (ISID) to overview recommendations on managing and preventing vascular catheter infections, specifically for the prevention and management of central line-associated bloodstream infections. These recommendations are intended to provide insight for healthcare professionals regarding the prevention of infection in the placement and maintenance of the catheter and diagnosis as well as treatment of catheter infection. Aspects of this area in pediatrics and in limited-resource situations and a discussion regarding the selection of empiric or targeted antimicrobial therapy are particular strengths of this position paper. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193018
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http://dx.doi.org/10.1016/j.ijid.2019.04.014DOI Listing
April 2019
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Making Learning Fun: Gaming in Radiology Education.

Acad Radiol 2019 Apr 17. Epub 2019 Apr 17.

University of Utah Hospital, Salt Lake City, Utah. Electronic address:

With continued technologic advances, it is not surprising that gaming techniques are increasingly being used in radiology residency programs. This comprehensive review on gaming in radiology education offers insight into the importance of gaming, types of games and principles utilized in gaming, as well as applications that are inherent in artificial intelligence and continued medical education. The advantages and disadvantages of gaming will be considered, as well as barriers to successful adoption of gaming. Read More

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http://dx.doi.org/10.1016/j.acra.2019.02.020DOI Listing

Identification of candidate genes in regulation of spermatogenesis in sheep testis following dietary vitamin E supplementation.

Anim Reprod Sci 2019 Apr 10. Epub 2019 Apr 10.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China. Electronic address:

Dietary vitamin E supplementation is beneficial to semen quality in different sheep and goat breeds. The aim of this research was to further investigate the effect of vitamin E in sheep on spermatogenesis and its regulatory mechanisms using RNA-seq. Thirty male Hu lambs were randomly divided into three groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784320183091
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http://dx.doi.org/10.1016/j.anireprosci.2019.04.003DOI Listing
April 2019
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Research evidence supports cancer policymaking but is insufficient for change: Findings of key informant interviews from five countries.

Health Policy 2019 Apr 13. Epub 2019 Apr 13.

Centre for Behavioural Research in Cancer, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, 3004, Australia; School of Psychology, Deakin University, 221 Burwood Hwy, Burwood, 3125, Australia.

Evidence-based policymaking values the use of research in the process of developing, implementing and evaluating policy. However, there is limited research attempting to understand how cancer policymaking occurs and the role of evidence in this process. Our study aimed to provide a deeper understanding of levers and challenges to the development and implementation of large-scale, health service policies or programs in cancer care. Read More

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http://dx.doi.org/10.1016/j.healthpol.2019.04.003DOI Listing

Ionic deep eutectic solvents for the extraction and separation of natural products.

J Chromatogr A 2019 Mar 30. Epub 2019 Mar 30.

Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China. Electronic address:

Room ionic liquids (ILs) used as green solvents have received considerable attention and wide application in different research and industrial fields, such as chemistry, biology, catalysis, energy, and even environmental sciences. Recently, a new class of sustainable solvents named deep eutectic solvents (DESs) have been developed, which share the promising solvent characteristics of ILs, such as thermal and chemical stability, low vapor pressure and design ability. In addition, the major advantages of DESs over ILs are their lower prices and easier preparation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219673193031
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http://dx.doi.org/10.1016/j.chroma.2019.03.046DOI Listing
March 2019
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Analysis of vibrational autoionization of CaF Rydberg states.

J Chem Phys 2019 Apr;150(15):154305

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

We report calculations of vibrational autoionization rates of CaF Rydberg states, based on the results of a global multi-channel quantum defect theory (MQDT) fit. Our goal is to use intuitive physical models to interpret and extend the results from the MQDT calculations and, in particular, to characterize the physical mechanisms for the interaction between the Rydberg electron and the ion-core. The calculations indicate that, among the six strongly l-mixed core-penetrating (CP) Rydberg series of CaF, the n. Read More

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http://aip.scitation.org/doi/10.1063/1.5091526
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http://dx.doi.org/10.1063/1.5091526DOI Listing
April 2019
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On the numerical solution of the exact factorization equations.

J Chem Phys 2019 Apr;150(15):154112

Department of Physics and Astronomy, Hunter College and the City University of New York, 695 Park Avenue, New York, New York 10065, USA.

The exact factorization (EF) approach to coupled electron-ion dynamics recasts the time-dependent molecular Schrödinger equation as two coupled equations, one for the nuclear wavefunction and one for the conditional electronic wavefunction. The potentials appearing in these equations have provided insight into non-adiabatic processes, and new practical non-adiabatic dynamics methods have been formulated starting from these equations. Here, we provide a first demonstration of a self-consistent solution of the exact equations, with a preliminary analysis of their stability and convergence properties. Read More

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http://dx.doi.org/10.1063/1.5090802DOI Listing

More than sulfidation: Roles of biogenic sulfide in attenuating the impacts of CuO nanoparticle on antibiotic resistance genes during sludge anaerobic digestion.

Water Res 2019 Apr 12;158:1-10. Epub 2019 Apr 12.

State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China. Electronic address:

Biogenic sulfide (BS) in anaerobic digesters was previously suggested to mitigate the potential impacts of metallic nanoparticles (M-NPs) on antibiotic resistance genes (ARGs) propagation by sulfidation of the M-NPs. In this study, a new role of BS in regulating ARGs responses to M-NPs is reported. It was observed that CuO NPs at environmentally relevant level had no significant effects on the spread of ARGs. Read More

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http://dx.doi.org/10.1016/j.watres.2019.04.019DOI Listing

Hierarchical fabrication Z-scheme photocatalyst of BiVO (0 4 0)-Ag@CdS for enhanced photocatalytic properties under simulated sunlight irradiation.

J Colloid Interface Sci 2019 Apr 15;548:293-302. Epub 2019 Apr 15.

School of Chemistry and Chemical Engineering, Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832003, PR China.

Interfacial charge separation and heterojunction system are conductive to improving its photocatalytic performance. Herein, we designed a novel photocatalyst of Z-scheme BiVO (0 4 0)-Ag@CdS, in which Ag was photo-deposition on the (0 4 0) facets of BiVO as the "linker" between BiVO and CdS. Characterizations of XRD and SEM clearly revealed that the BiVO (0 4 0)-Ag@CdS was prepared through hierarchical fabrication. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.043DOI Listing

Synergism of open chromatin regions involved in regulating genes in Bombyx mori.

Insect Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Biological Science Research Center, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing 400715, China. Electronic address:

The dynamic variability of transcription factors (TFs) and their binding sites makes it challenging to conduct genome-wide transcription regulation research. The silkworm Bombyx mori, which produces silk, is one of the most valuable model insects in the order Lepidoptera. The "opening" and "closing" of chromatin in different silk yield strains is associated with changes in silk production, making this insect a good model for studying the transcriptional regulation of genes. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.014DOI Listing
April 2019
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