9,900 results match your criteria IEEE transactions on bio-medical engineering[Journal]


A Spine-Specific Phased Array for Transvertebral Ultrasound Therapy: Design & Simulation.

IEEE Trans Biomed Eng 2019 Apr 18. Epub 2019 Apr 18.

Objective: To design and simulate the performance of two spine-specific phased arrays in sonicating targets spanning the thoracic spinal canal, with the objective of efficiently producing controlled foci in the spinal canal.

Methods: Two arrays (256 elements each, 500 kHz) were designed using multi-layered ray acoustics simulation; a 4-component array with dedicated components for sonicating via the paravertebral and transvertebral paths, and a 2-component array with spine-specific adaptive focusing. Mean array efficiency (canal focus pressure/water focus pressure) was evaluated using forward simulation in neutral and flexed spines. Read More

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http://dx.doi.org/10.1109/TBME.2019.2912146DOI Listing
April 2019
1 Read

A Riemannian geometry approach to reduced and discriminative covariance estimation in Brain Computer Interfaces.

IEEE Trans Biomed Eng 2019 Apr 18. Epub 2019 Apr 18.

Objective: Spatial covariance matrices are extensively employed as brain activity descriptors in BCI research that, typically, involve the whole array of sensors. Here, we introduce a methodological framework for delineating the subset of sensors, the covariance structure of which offers a reduced, but more powerful, representation of brain's coordination patterns that ultimately leads to reliable mind reading.

Methods: Adopting a Riemannian geometry approach, we turn the problem of sensor selection as a maximization of a functional that is computed over the manifold of symmetric positive definite (SPD) matrices and encapsulates class separability in a way that facilitates the search among subsets of different size. Read More

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http://dx.doi.org/10.1109/TBME.2019.2912066DOI Listing
April 2019
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Analysis of miniaturization effects and channel selection strategies for EEG sensor networks with application to auditory attention detection.

IEEE Trans Biomed Eng 2019 Apr 17. Epub 2019 Apr 17.

Objective: Concealable, miniaturized electroencephalography ('mini-EEG') recording devices are crucial enablers towards long-term ambulatory EEG monitoring. However, the resulting miniaturization limits the inter-electrode distance and the scalp area that can be covered by a single device. The concept of wireless EEG sensor networks (WESNs) attempts to overcome this limitation by placing a multitude of these mini-EEG devices at various scalp locations. Read More

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http://dx.doi.org/10.1109/TBME.2019.2911728DOI Listing

Electric Stimulus-Responsive Chitosan/MNP composite Microbeads for a Drug Delivery System.

IEEE Trans Biomed Eng 2019 Apr 16. Epub 2019 Apr 16.

In the last several years, conventional Drug Delivery Systems (DDS) have evolved into DDS that are responsive to exogenous or endogenous stimuli. The objective of this work was to present a DDS that is responsive to an electric stimulus, in the form of bipolar electric pulses. The DDS structure is based on chitosan embedded with magnetic nanoparticles, and crosslinked with polyethylene glycol dimethacrylate to form microbeads. Read More

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https://ieeexplore.ieee.org/document/8692615/
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http://dx.doi.org/10.1109/TBME.2019.2911579DOI Listing
April 2019
3 Reads

Prospective Respiration-Gated Photoacoustic Microscopy.

IEEE Trans Biomed Eng 2019 Apr 16. Epub 2019 Apr 16.

Objective: Photoacoustic microscopy (PAM) is a promising biomedical imaging technique that relies on sequential excitation to generate three-dimensional images. It combines the high contrast of optical imaging with high penetration depth of ultrasound imaging. The normal respiration rate of mice is greater than 3 Hz, which leads to motion artifacts in most reported PAM for in-vivo imaging. Read More

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https://ieeexplore.ieee.org/document/8692629/
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http://dx.doi.org/10.1109/TBME.2019.2911551DOI Listing
April 2019
2 Reads

Risks and Benefits of Using a Commercially Available Ventricular Assist Device for Failing Fontan Cavopulmonary Support: A Modeling Investigation.

IEEE Trans Biomed Eng 2019 Apr 16. Epub 2019 Apr 16.

Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure boost. However, there is currently no commercially available device designed for the cavopulmonary application; and the risks and benefits of implanting a ventricular assist device (VAD) originally designed for the left ventricular application on the right circulation of failing Fontan patients is not yet clear. Read More

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http://dx.doi.org/10.1109/TBME.2019.2911470DOI Listing

Electrocardiogram-Derived Tidal Volume During Treadmill Stress Test.

IEEE Trans Biomed Eng 2019 Apr 15. Epub 2019 Apr 15.

Objective: Electrocardiogram (ECG) has been regarded as a source of respiratory information with the main focus in the estimation of the respiratory rate. Although little research concerning the estimation of tidal volume (TV) has been conducted, there are several ECG-derived features that have been related with TV in the literature, such as ECG-derived respiration, heart rate variability or respiratory rate. In this work, we exploited these features for estimating TV using a linear model. Read More

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http://dx.doi.org/10.1109/TBME.2019.2911351DOI Listing
April 2019
4 Reads

Multi-parametric Standardization of Fluorescence Imaging Systems Based on a Composite Phantom.

IEEE Trans Biomed Eng 2019 Apr 11. Epub 2019 Apr 11.

Objective: Fluorescence molecular imaging (FMI) has emerged as a promising tool for surgical guidance in oncology, with one of the few remaining challenges being the ability to offer quality control and data referencing. This study investigates the use of a novel composite phantom to correct and benchmark FMI systems.

Methods: This study extends on previous work by describing a phantom design that can provide a more complete assessment of FMI systems through quantification of dynamic range and determination of spatial illumination patterns for both reflectance and fluorescence imaging. Read More

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http://dx.doi.org/10.1109/TBME.2019.2910733DOI Listing

Pediatric Airway Stent Designed to Facilitate Mucus Transport and Atraumatic Removal.

IEEE Trans Biomed Eng 2019 Apr 11. Epub 2019 Apr 11.

Objective: The goal was to develop a pediatric airway stent for treating tracheobronchomalacia that could be used as an alternative to positive pressure ventilation. The design goals were for the stent to allow mucus flow and to resist migration inside the airways while also enabling easy insertion and removal.

Methods: A helical stent design together with insertion and removal tools are presented. Read More

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http://dx.doi.org/10.1109/TBME.2019.2910551DOI Listing

Smart Toolkit for Fluorescence Tomography: simulation, reconstruction, and validation.

IEEE Trans Biomed Eng 2019 Apr 11. Epub 2019 Apr 11.

Objective: Fluorescence molecular tomography (FMT) can provide valuable molecular information by mapping the bio-distribution of fluorescent reporter molecules in the intact organism. Various prototype FMT systems have been introduced during the past decade. However, none of them has evolved as a standard tool for routine biomedical research. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907460DOI Listing

An Ankle-Foot Prosthesis Emulator Capable of Modulating Center of Pressure.

IEEE Trans Biomed Eng 2019 Apr 9. Epub 2019 Apr 9.

Objective: Several powered ankle-foot prostheses have demonstrated moderate reductions in energy expenditure by restoring pushoff work in late stance or by assisting with balance. However, it is possible that center of pressure trajectory modulation could provide even further improvements in user performance. Here we describe the design of a prosthesis emulator with two torque-controlled forefoot digits and a torquecontrolled heel digit. Read More

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http://dx.doi.org/10.1109/TBME.2019.2910071DOI Listing
April 2019
5 Reads

Real-time Passive Brain Monitoring System Using Near-Field Microwave Radiometry.

IEEE Trans Biomed Eng 2019 Apr 9. Epub 2019 Apr 9.

Objective: Near-field microwave radiometry has emerged as a tool for real time passive monitoring of local brain activation possibly attributed to local changes in blood flow that correspond to temperature and/or conductivity changes. The aim of this study is to design and evaluate a prototype system based on microwave radiometry intended to detect local changes of temperature and conductivity in depth in brain tissues. A novel radiometric system that comprises a four port total power Dicke-switch sensitive receiver that operates at 1. Read More

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http://dx.doi.org/10.1109/TBME.2019.2909994DOI Listing
April 2019
2 Reads

Smart Triggering of the Barometer in a Fall Detector using a Semi-permeable Membrane.

IEEE Trans Biomed Eng 2019 Apr 9. Epub 2019 Apr 9.

The inclusion of a barometer in a wearable fall detector has been shown to improve the detection accuracy by measuring the altitude change associated with a fall event. However, the barometer is a power-hungry sensor, and the sensing power of barometer can be the dominant power consumption source in a wearable fall detector. In this study, we propose a triggering method that reduces barometer power consumption and prolongs the battery life. Read More

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http://dx.doi.org/10.1109/TBME.2019.2909907DOI Listing
April 2019
1 Read

Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds.

IEEE Trans Biomed Eng 2019 Apr 9. Epub 2019 Apr 9.

Objective: Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate on the atrial manifold and neglect uncertainties associated with LAT observations. In this paper we describe novel methods to (i) quantify uncertainties in LAT arising from bipolar electrogram analysis and assignment of electrode recordings to the anatomical mesh, (ii) interpolate uncertain LAT measurements directly on left atrial manifolds to obtain complete probabilistic activation maps, and (iii) interpolate LAT jointly across both the manifold and different S1-S2 pacing protocols.

Methods: A modified center of mass approach was used to process bipolar electrograms, yielding a LAT estimate and error distribution from the electrogram morphology. Read More

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http://dx.doi.org/10.1109/TBME.2019.2908486DOI Listing
April 2019
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Model-based estimation of individual muscle force based on measurements of muscle activity in forearm muscles during isometric tasks.

IEEE Trans Biomed Eng 2019 Apr 3. Epub 2019 Apr 3.

Objective: Several forward dynamics estimation approaches have been proposed to estimate individual muscle force. However, characterization of the estimation error that arises when measurements are available only from a subset of the muscles involved in the movement under analysis, as it is the case of the forearm muscles, has been limited. Our objectives were: 1) to quantify the accuracy of forward-dynamics muscle force estimators for forearm muscles; 2) to develop a muscle force estimator that is accurate even when measurements are available only from a subset of muscles acting on a given joint or segment. Read More

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http://dx.doi.org/10.1109/TBME.2019.2909171DOI Listing
April 2019
2 Reads

Dynamic-DeepHit: A Deep Learning Approach for Dynamic Survival Analysis with Competing Risks based on Longitudinal Data.

IEEE Trans Biomed Eng 2019 Apr 3. Epub 2019 Apr 3.

Currently available risk prediction methods are limited in their ability to deal with complex, heterogeneous, and longitudinal data such as that available in primary care records, or in their ability to deal with multiple competing risks. This paper develops a novel deep learning approach that is able to successfully address current limitations of standard statistical approaches such as landmarking and joint modeling. Our approach, which we call Dynamic-DeepHit, flexibly incorporates the available longitudinal data comprising various repeated measurements (rather than only the last available measurements) in order to issue dynamically updated survival predictions for one or multiple competing risk(s). Read More

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https://ieeexplore.ieee.org/document/8681104/
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http://dx.doi.org/10.1109/TBME.2019.2909027DOI Listing
April 2019
3 Reads
2.347 Impact Factor

N-BiC: A method for multi-component and symptom biclustering of structural MRI data: Application to schizophrenia.

IEEE Trans Biomed Eng 2019 Apr 1. Epub 2019 Apr 1.

Objective: We propose and develop a novel biclustering (N-BiC) approach for performing N-way biclustering of neuroimaging data. Our approach is applicable to an arbitrary number of features from both imaging and behavioral data (e.g. Read More

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http://dx.doi.org/10.1109/TBME.2019.2908815DOI Listing
April 2019
3 Reads

Information Theoretic Feature Transformation Learning for Brain Interfaces.

IEEE Trans Biomed Eng 2019 Mar 28. Epub 2019 Mar 28.

Objective: A variety of pattern analysis techniques for model training in brain interfaces exploit neural feature dimensionality reduction based on feature ranking and selection heuristics. In the light of broad evidence demonstrating the potential sub-optimality of ranking based feature selection by any criterion, we propose to extend this focus with an information theoretic learning driven feature transformation concept.

Methods: We present a maximum mutual information linear transformation (MMI-LinT), and a nonlinear transformation (MMI-NonLinT) framework derived by a general definition of the feature transformation learning problem. Read More

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http://dx.doi.org/10.1109/TBME.2019.2908099DOI Listing
March 2019
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Catheter-based polarization sensitive optical coherence tomography using similar Mueller matrix method.

IEEE Trans Biomed Eng 2019 Mar 28. Epub 2019 Mar 28.

Objective: Research of catheter-based polarization sensitive optical coherence tomography (PS-OCT) is a challenging field. In this paper, we present a new polarization determination method, similar Mueller matrix (SMM) method, for a catheter-based PS-OCT system using a standard clinical catheter probe with an outer diameter of 0.9 mm. Read More

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https://ieeexplore.ieee.org/document/8676059/
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http://dx.doi.org/10.1109/TBME.2019.2908031DOI Listing
March 2019
10 Reads

Characterizing the Motor points of Forearm Muscles for Dexterous Neuroprostheses.

IEEE Trans Biomed Eng 2019 Mar 28. Epub 2019 Mar 28.

Background: Surface stimulation systems facilitate dexterous manipulation by achieving targeted and isolated activation of muscle groups through motor point-based stimulation. Existing catalogues on motor points lacks generalization and reproducibility as they are mostly based on anatomical charts and were obtained from heterogeneous studies.

Objective: By systematically identifying and characterizing the motor points, the aim of this study is to address these limitations and improve the utilization of motor point catalogues towards the design and control for surface stimulation systems, that are targeted to restore complete hand function. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907926DOI Listing

Towards Decoding Selective Attention from Single-Trial EEG Data in Cochlear Implant Users.

IEEE Trans Biomed Eng 2019 Mar 26. Epub 2019 Mar 26.

Previous results showed that it is possible to decode an attended speech source from EEG data via the reconstruction of the speech envelope in normal hearing (NH) listeners. However, so far it is unknown how the performance of such a decoder is affected by the decrease in spectral resolution and the electrical artifacts introduced by a cochlear implant (CI) in users of these prostheses. NH-listeners and bilateral CI-users participated in the present study. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907638DOI Listing
March 2019
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Enhancing Image Quality of Photoacoustic Tomography using Sub-Pitch Array Translation Approach: Simulation and Experimental Validation.

IEEE Trans Biomed Eng 2019 Mar 26. Epub 2019 Mar 26.

Objective: The purpose of this work is to present a more convenient and practical alternate way of increasing the lateral discrete array sampling while using a typical λ pitch linear array transducer at receive for PAT application.

Methods: We have employed a linear translation-based approach in which the array transducer is translated by sub-pitch amount to create an augmented RF frame data having denser lateral spatial sampling. The denser λ/2 and λ/4 pitch data was reconstructed and compared against conventional λ pitch reconstructed PAT image using simulation and tissue mimicking phantom experiments in terms of improvements in resolution and contrast. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907559DOI Listing

Steering capabilities of an acoustic lens for transcranial therapy: numerical and experimental studies.

IEEE Trans Biomed Eng 2019 Mar 26. Epub 2019 Mar 26.

For successful brain therapy, transcranial focused ultrasound must compensate for the time shifts induced locally by the skull. The patient-specific phase profile is currently generated by multi-element arrays which, over time, have tended towards increasing element count. We recently introduced a new approach, consisting of a single-element transducer coupled to an acoustic lens of controlled thickness. Read More

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https://ieeexplore.ieee.org/document/8674581/
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http://dx.doi.org/10.1109/TBME.2019.2907556DOI Listing
March 2019
9 Reads

Smoother-based 3D Foot Trajectory Estimation Using Inertial Sensors.

IEEE Trans Biomed Eng 2019 Mar 26. Epub 2019 Mar 26.

Objective: Measuring 3D foot trajectories with foot- worn IMUs (inertial measurement units) is essential for a variety of applications, such as gait analysis and fall risk assessment. IMU-based foot trajectory is reconstructed usually by double integrating the global coordinate acceleration, in which drifts of signals are accumulated and lead to unbounded error increase. To reduce drift errors, a smoother-based method is proposed in this paper. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907322DOI Listing
March 2019
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A Parametric Time Frequency-Conditional Granger Causality Method Using Ultra-regularized Orthogonal Least Squares and Multiwavelets for Dynamic Connectivity Analysis in EEGs.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

Objective: This study proposes a new para-metric TF-CGC (time-frequency conditional Granger causality) method for high-precision connectivity analysis over time and frequency domain in multivariate coupling nonstationary systems, and applies it to source EEG signals to reveal dynamic interaction patterns in oscillatory neo-cortical sensorimotor networks.

Methods: The Geweke's spectral measure is combined with the TVARX (time-varying autoregressive with exogenous input) model-ling approach, which uses multiwavelet-based ul-tra-regularized orthogonal least squares (UROLS) algo-rithm aided by APRESS (adjustable prediction error sum of squares), to obtain high-resolution time-varying CGC representations. The UROLS-APRESS algorithm, which adopts both the regularization technique and the ultra-least squares criterion to measure not only the signal themselves but also the weak derivatives of them, is a novel powerful method in constructing time-varying models with good generalization performance, and can accurately track smooth and fast changing causalities. Read More

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http://dx.doi.org/10.1109/TBME.2019.2906688DOI Listing
March 2019
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Dilated-Inception Net: Multi-Scale Feature Aggregation for Cardiac Right Ventricle Segmentation.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

Segmentation of cardiac ventricle from magnetic resonance images is significant for cardiac disease diagnosis, progression assessment and monitoring cardiac conditions. Manual segmentation is so time-consuming, tedious, and subjective that automated segmentation methods are highly desired in practice. However, conventional segmentation methods performed poorly in cardiac ventricle, especially in the right ventricle. Read More

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http://dx.doi.org/10.1109/TBME.2019.2906667DOI Listing

Efficient Decoding of Multi-Dimensional Signals from Population Spiking Activity Using a Gaussian Mixture Particle Filter.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

New recording technologies and the potential for closed-loop experiments have led to an increasing demand for computationally efficient and accurate algorithms to decode population spiking activity in multi-dimensional spaces. Exact point process filters can accurately decode low dimensional signals, but are computationally intractable for high dimensional signals. Approximate Gaussian filters are computationally efficient but are inaccurate when the signals have complex distributions and nonlinear dynamics. Read More

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http://dx.doi.org/10.1109/TBME.2019.2906640DOI Listing
March 2019
1 Read
2.347 Impact Factor

A Minimally Invasive Hollow Microneedle with a Cladding Structure: Ultra-Thin but Strong, Batch Manufacturable.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

Objective: A minimally invasive hollow in-plane microneedle with a cladding structure is designed to improve the mechanical strength.

Methods: The traditional weak stack structure has been changed into a cladding structure, and the effectiveness has been validated through finite element analysis (FEA). The prototypes of the microneedles were batch manufactured by the integrated micromachining process with no need to assemble. Read More

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http://dx.doi.org/10.1109/TBME.2019.2906571DOI Listing
March 2019
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Viscous Heating Assists Jet Formation During Needle-free Jet Injection of Viscous Drugs.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

Objective: Jet injectors use a high-pressure liquid jet to pierce the skin and deliver drug into underlying tissues. This jet is formed through a short, narrow orifice; the geometry of the orifice and the properties of the fluid affect the nature of the flow. We aimed to discover information about the turbulent and viscous processes that contribute to pressure loss and flow patterns during jet injection. Read More

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http://dx.doi.org/10.1109/TBME.2019.2906356DOI Listing
March 2019
2 Reads

Energy Cost of Action Potential Generation and Propagation in Thalamocortical Relay Neurons During Deep Brain Stimulation.

IEEE Trans Biomed Eng 2019 Mar 27. Epub 2019 Mar 27.

Thalamocortical (TC) relay neurons generate antidromic and orthodromic action potentials (APs) during thalamic deep brain stimulation (DBS). To maintain signaling, each AP requires Na+/K+ pump to expend ATP to restore Na+ and K+ gradients. Our aim was to estimate the energy demand associated with AP generation and propagation within TC relay cells during DBS. Read More

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https://ieeexplore.ieee.org/document/8675303/
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http://dx.doi.org/10.1109/TBME.2019.2906114DOI Listing
March 2019
2 Reads

Improving musculoskeletal model scaling using an anatomical atlas: the importance of gender and anthropometric similarity to quantify joint reaction forces.

IEEE Trans Biomed Eng 2019 Mar 28. Epub 2019 Mar 28.

Objective: The accuracy of a musculoskeletal model relies heavily on the implementation of the underlying anatomical dataset. Linear scaling of a generic model, despite being time and cost-efficient, produces substantial errors as it does not account for gender differences and inter-individual anatomical variations. The hypothesis of this study is that linear scaling to a musculoskeletal model with gender and anthropometric similarity to the individual subject produces similar results to the ones that can be obtained from a subject-specific model. Read More

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http://dx.doi.org/10.1109/TBME.2019.2905956DOI Listing
March 2019
1 Read

Noninvasive Estimation of Electrical Properties from Magnetic Resonance Measurements via Global Maxwell Tomography and Match Regularization.

IEEE Trans Biomed Eng 2019 Mar 25. Epub 2019 Mar 25.

Objective: In this paper, we introduce Global Maxwell Tomography (GMT), a novel, volumetric technique that estimates electric conductivity and permittivity by solving an inverse scattering problem based on magnetic resonance measurements.

Methods: GMT relies on a fast volume integral equation solver, MARIE, for the forward path and a novel regularization method, Match Regularization, designed specifically for electrical properties estimation from noisy measurements. We performed simulations with three different tissue-mimicking numerical phantoms of different complexity, using synthetic transmit sensitivity maps with realistic noise levels as the measurements. Read More

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https://ieeexplore.ieee.org/document/8673893/
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http://dx.doi.org/10.1109/TBME.2019.2907442DOI Listing
March 2019
3 Reads
2.347 Impact Factor

Nanosecond Pulse Electroporator with Silicon Carbide MOSFETs, Development and Evaluation.

IEEE Trans Biomed Eng 2019 Mar 25. Epub 2019 Mar 25.

Nanosecond electroporation of cell organelles is being studied for more than a decade, but it is still not entirely understood. Unique prototype hardware equipment and challenging measuring methods may also be a contributing reason for this situation. In the scope of this paper we improve the performance of the high-voltage nanosecond pulse generator by introducing Silicon carbide (SiC) MOSFETs. Read More

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http://dx.doi.org/10.1109/TBME.2019.2907165DOI Listing

Cardiac Tissue Chips (CTCs) for Modelling Cardiovascular Disease.

IEEE Trans Biomed Eng 2019 Mar 18. Epub 2019 Mar 18.

Objective: Cardiovascular research and regenerative strategies have been significantly limited by the lack of relevant cell culture models that can recreate complex hemodynamic stresses associated with pressure-volume changes in the heart.

Methods: To address this issue, we designed a Biomimetic Cardiac Tissue Chip (CTC) Model where encapsulated cardiac cells can be cultured in 3D fibres and subjected to hemodynamic loading to mimic pressure-volume changes seen in the left ventricle. These 3D fibres are suspended within a microfluidic chamber between two posts and integrated within a flow loop. Read More

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http://dx.doi.org/10.1109/TBME.2019.2905763DOI Listing
March 2019
2 Reads

Ex Vivo Evaluation of Mouse Brain Elasticity Using High-Frequency Ultrasound Elastography.

IEEE Trans Biomed Eng 2019 Mar 18. Epub 2019 Mar 18.

Objective: Most neurodegenerative diseases are highly linked with aging. The mechanical properties of the brain should be determined for predicting and diagnosing age-related brain diseases. A preclinical animal study is crucial for neurological disease research. Read More

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https://ieeexplore.ieee.org/document/8668542/
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http://dx.doi.org/10.1109/TBME.2019.2905551DOI Listing
March 2019
5 Reads

Development of an apparatus for digital measurement of magnetically induced torque on medical implants to facilitate the application of the ASTM F2213 standard.

IEEE Trans Biomed Eng 2019 Mar 15. Epub 2019 Mar 15.

Objective: The ASTM F2213 standard describes the measurement of the magnetically induced torques by means of a torsional spring method. As this method is highly complex, it has been rarely ever employed. The purpose was to develop an easy-to-handle measuring setup for the reproducible, fast and precise measurement of magnetically induced torques, following ASTM F2213, at a static magnetic field (B) of 1. Read More

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https://ieeexplore.ieee.org/document/8667727/
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http://dx.doi.org/10.1109/TBME.2019.2905236DOI Listing
March 2019
5 Reads

4D Flow MRI-Based Computational Analysis of Blood Flow in Patient-Specific Aortic Dissection.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Objective: Computational hemodynamics studies of aortic dissections usually combine patient-specific geometries with idealized or generic boundary conditions. In this study we present a comprehensive methodology for simulations of hemodynamics in type B aortic dissection (TBAD) based on fully patient-specific BCs.

Methods: Pre-operative 4D flow magnetic resonance imaging (MRI) and Doppler-wire pressure measurements (pre- and post-operative) were acquired from a TBAD patient. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904885DOI Listing
March 2019
3 Reads

Automated characterization of anthropomorphicity of prosthetic feet fitted to bone-anchored transtibial prosthesis.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Objective: This study describes differentiating prosthetic feet designs fitted to bone-anchored transtibial prostheses based on an automated characterization of ankle stiffness profile relying on direct loading measurements. The objectives were (A) to present a process characterizing stiffness using innovative macro, meso and micro analyses, (B) to present stiffness profiles for feet with and without anthropomorphic designs, where anthropomorphicity is defined as a similarity of the moment-angle dependency in prosthetic and in the anatomical ankle, (C) to determine sensitivity of characterization.

Methods: Three participants walked consecutively with two instrumented bone-anchored prostheses including their own prosthetic feet and Free-Flow foot meeting the anthropomorphicity criterion by design. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904713DOI Listing
March 2019
2.347 Impact Factor

In vivo Visualization of Brain Vasculature in Alzheimer's Disease Mice by High-Frequency Micro-Doppler Imaging.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Objective: Cerebrovascular disorders are associated with Alzheimer's disease (AD). Functional analysis of the cerebral vasculature requires an in vivo approach to visualize the blood flow in small animal brains. This paper proposes high-frequency micro-Doppler imaging (HFμDI) technology for mapping mouse cerebral vasculature. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904702DOI Listing
March 2019
6 Reads

A Single Sensor Dual-modality Photoacoustic Fusion Imaging for Compensation of Light Fluence Variation.

IEEE Trans Biomed Eng 2019 Mar 12. Epub 2019 Mar 12.

Objective: A photoacoustic signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative photoacoustic measurements of the optical absorption coefficients therefore require an accurate compensation of optical fluence variation. Usually, an additional diffuse optical tomography (DOT) is incorporated to estimate the light fluence variation, but it is often troubled with the bulky measurement system. On this note, we present a dual-modality photoacoustic fusion imaging method that is implemented with a normal photoacoustic imaging (PAI) device. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904502DOI Listing
March 2019
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Multi-Resolution Graph Based Volumetric Cortical Basis Functions from Local Anatomic Features.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Objective: Modern clinical MRI collects millimeter scale anatomic information, but scalp electroencephalography (EEG) source localization (ESL) is ill-posed, and cannot resolve individual sources at that resolution. Dimensionality reduction in the space of cortical sources is needed to improve computational and storage complexity. Surface based cortical source models allow scalable complexity, but volumetric methods still employ simplistic grid coarsening that eliminates fine scale anatomic structure. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904473DOI Listing

Effects of Video Encoding on Camera Based Heart Rate Estimation.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Objective: Public databases are important for evaluating and comparing different methods and algorithms for camera based heart rate estimation. Because uncompressed video requires huge file sizes, a need for compression algorithms exists to store and share video data. Due to the optimization of modern video codecs for human perception, video compression can influence heart rate estimation negatively by reducing or eliminating small color changes of the skin (PPG) that are needed for camera based heart rate estimation. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904326DOI Listing

Deep collaborative learning with application to multimodal brain development study.

IEEE Trans Biomed Eng 2019 Mar 13. Epub 2019 Mar 13.

Multi-modal fMRI imaging has been used to study brain development such as the difference of functional connectivities (FCs) between different ages. Canonical correlation analysis (CCA) has been used to find correlations between multiple imaging modalities. However, it is unrelated to phenotypes. Read More

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https://ieeexplore.ieee.org/document/8666981/
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http://dx.doi.org/10.1109/TBME.2019.2904301DOI Listing
March 2019
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A Dichotomization Winding Scheme on a Novel Asymmetric Head Gradient Coil Design with an Improved Force and Torque Balance.

IEEE Trans Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

The head gradient coil is advantageous for brain imaging compared with the conventional whole-body gradient coil; it is usually asymmetrically designed for the accommodation of human shoulders. The asymmetric head coil has a specific issue associated with an unbalanced force/torque that requires minimization for imaging applications. This work will improve the force and torque balance solution and propose a dichotomization winding scheme to augment the coil slew rate. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904213DOI Listing

A mathematical model of dP/dt max for the evaluation of the dynamic control of heart contractility in septic shock.

IEEE Trans Biomed Eng 2019 Mar 12. Epub 2019 Mar 12.

Objective: Septic shock (SS) patients often show elevated heart rate (HR) despite resuscitation and this condition is considered an early manifestation of myocardial dysfunction, due to an impairment of autonomic nervous system (ANS). We aimed at proposing a mathematical model to assess the autonomic control of ventricular contractility (VC) and HR to track changes in heart functionality during an experimental animal model of SS and resuscitation.

Methods: Septic shock was induced in six adult swine by polymicrobial peritonitis. Read More

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http://dx.doi.org/10.1109/TBME.2019.2894333DOI Listing
March 2019
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A Modular, Smart, and Wearable System for High Density sEMG Detection.

IEEE Trans Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

Objective: The use of linear or bi-dimensional electrode arrays for surface EMG detection (HD-sEMG) is gaining attention as it increases the amount and reliability of information extracted from surface EMG. However, the complexity of the setup and the encumbrance of HD-sEMG hardware currently limits its use in dynamic conditions. The aim of this work was to develop a miniaturized, wireless, and modular HD-sEMG acquisition system for applications requiring high portability and robustness to movement artifacts. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904398DOI Listing
March 2019
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Real-time Photoacoustic Thermometry Combined with Clinical Ultrasound Imaging and High Intensity Focused Ultrasound.

IEEE Trans Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

High intensity focused ultrasound (HIFU) treatment is a promising non-invasive method for killing or destroying the diseased tissues by locally delivering thermal and mechanical energy without damaging surrounding normal tissues. In HIFU, measuring the temperature at the site of delivery is important for improving therapeutic efficacy, controlling safety, and appropriately planning a treatment. Several researchers have proposed photoacoustic thermometry for monitoring HIFU treatment, but they had many limitations, including cannot image while the HIFU is on, cannot provide 2D monitoring, or cannot be used clinically. Read More

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http://dx.doi.org/10.1109/TBME.2019.2904087DOI Listing
March 2019
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A Formal Approach for Scalable Simulation of Gastric ICC Electrophysiology.

IEEE Trans Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

Objective: Efficient and accurate organ models are crucial for closed-loop validation of implantable medical devices. This paper investigates bio-electric slow wave modeling of the stomach, so that Gastric Electrical Stimulator (GES) can be validated and verified prior to implantation. In particular, we consider high-fidelity, scalable, and efficient modeling of the pacemaker, Interstitial Cells of Cajal (ICC), based on the formal Hybrid Input Output Automata (HIOA) framework. Read More

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https://ieeexplore.ieee.org/document/8664136/
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http://dx.doi.org/10.1109/TBME.2019.2904043DOI Listing
March 2019
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Robust Fetal Heart Beat Detection via R-peak Intervals Distribution.

IEEE Trans Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

Monitoring fetal heart rate during pregnancy is essential to assist clinicians in making more timely decisions. Non-invasive monitoring of fetal heart activities using abdominal ECGs is useful for diagnosis of heart defects. However, the extracted fetal ECGs are usually too weak to be robustly detected. Read More

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https://ieeexplore.ieee.org/document/8664129/
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http://dx.doi.org/10.1109/TBME.2019.2904014DOI Listing
March 2019
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Investigating the Effect of Short Term Responsive VNS Therapy on Sleep Quality Using Automatic Sleep Staging.

IEEE Trans Biomed Eng 2019 Mar 8. Epub 2019 Mar 8.

Objective: The goal of this work is to objectively evaluate the effectiveness of responsive (or closed-loop) Vagus nerve stimulation (VNS) therapy in sleep quality in patients with medically refractory epilepsy.

Methods: Using quantitative features obtained from electroencephalography (EEG), we first developed a new automatic sleep-staging framework that consists of a multi-class support vector machine (SVM) classification based on a decision tree approach. To train and evaluate the performance of the framework, we used polysomnographic data of 23 healthy subjects from the PhysioBank database where the sleep stages have been visually annotated. Read More

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http://dx.doi.org/10.1109/TBME.2019.2903987DOI Listing
March 2019
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