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Reprod Biomed Online 2022 May 5. Epub 2022 May 5.

Hysteroscopic Center, Fuxing Hospital, The Eighth Clinical Medical College, Capital Medical University Beijing, China; Department of Obstetrics and Gynecology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.

Research Question: What is the efficacy of auto-cross-linked hyaluronic acid gel use in preventing adhesion reformation after intrauterine adhesiolysis?

Design: This was a single-centre, double-blind randomized controlled trial.

Results: In total 171 participants successfully completed the study (84 in the treatment group and 87 in the control group). There was no significant difference in pre-operative variables between the two groups. Read More

Aust N Z J Obstet Gynaecol 2022 Jun 26. Epub 2022 Jun 26.

Endosurgery (Gynaecology) Department, Mercy Hospital for Women, Heidelberg, Melbourne, Victoria, Australia.

Background: Postmenopausal bleeding (PMB), a common symptom of endometrial cancer, necessitates prompt clinical and sonographic assessment, often followed by hysteroscopy. Unfortunately, due to traditional gynaecology outpatient clinic paradigms, unnecessary patient-clinician encounters are common and may lead to delays in diagnosis.

Aim: The aim was to assess a novel clinic model for the management of women with PMB based on virtual assessment and routine use of the outpatient hysteroscopy clinic. Read More

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Department of Obstetrics and Gynecology, Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Despite the rise of medical treatments for the termination of pregnancy, to-date no prospective trial has evaluated the efficacy of misoprostol in treating retained products of conception after induced termination of pregnancy.

Objective: To compare medical management with misoprostol with expectant management for retained products of conception after first trimester medical termination of pregnancy.

Study Design: An open-label randomized controlled trial conducted at a university-affiliated tertiary medical center. Read More

Gynecol Minim Invasive Ther 2022 Apr-Jun;11(2):116-118. Epub 2022 May 4.

Department of Gynecology and Obstetric, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Isthmocele can be defined as a hypoechoic field within the lower uterine segment, indicating a discontinuation of the myometrium at the uterine scar of a previous cesarean section. Postmenstrual spotting, pelvic pain, dysmenorrhea, dyspareunia, uterine rupture, cesarean scar pregnancy, and secondary infertility could be seen as the complications of existing isthmocele. Such defects are prevalent with the increasing number of cesarean deliveries. Read More

Diagnostics (Basel) 2022 Jun 2;12(6). Epub 2022 Jun 2.

Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.

Tubal factor is an important contributor to female infertility, and the current diagnostic approaches cannot correctly identify many subtle causes of tubal dysfunction. While it is known that the most common cause of tubal factor infertility is pelvic inflammatory disease (PID), creating critical alterations of the tubal epithelium, little attention has been devoted to understanding the tubal modifications caused by the resident microbial population and their interaction with the surrounding tubal epithelium. Furthermore, most of these samples are obtained by traumatic procedures such as direct sampling during laparoscopy using a cytobrush. Read More

BMC Womens Health 2022 Jun 23;22(1):250. Epub 2022 Jun 23.

Department of General Gynaecology and Urogynaecology, Clinic for Gynaecology and Perinatology, University Medical Centre Maribor, Ljubljanska 5, 2000, Maribor, Slovenia.

Background: The objective of our study was to assess the rate and causes for Essure® micro-insert system removal and patients' long term satisfaction rate with the procedure.

Methods: All patients who underwent Essure® hysteroscopic sterilization at our tertiary centre between years 2007 and 2018 were included in this follow-up study. A questionnaire was sent to all patients per standard mail. Read More

Bioengineering (Basel) 2022 May 30;9(6). Epub 2022 May 30.

Personalised Medicine Centre, 197341 St. Petersburg, Russia.

The inner parts of the human body are usually inspected endoscopically using special equipment. For instance, each part of the female reproductive system can be examined endoscopically (laparoscopy, hysteroscopy, and colposcopy). The primary purpose of colposcopy is the early detection of malignant lesions of the cervix. Read More

Eur J Obstet Gynecol Reprod Biol 2022 Jun 16;275:54-58. Epub 2022 Jun 16.

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Objective: To collect information on the application and behavior of a novel degradable polymeric film (DPF) developed to prevent intra-uterine adhesions (IUAs) after hysteroscopic surgery.

Study Design: A prospective observational study conducted in a university hospital in Naples, Italy. Women undergoing hysteroscopic myomectomy, metroplasty or adhesiolysis, were eligible for the study. Read More

Eur J Contracept Reprod Health Care 2022 Jun 21:1-6. Epub 2022 Jun 21.

Department of Reproductive Endocrinology and IVF, University of Health Sciences, Etlik Zubeyde Hanim Women's Health, Training and Research Hospital, Ankara, Turkey.

Objective: T/Y-shaped dysmorphic uterus is frequently associated with subfertility, abortion, preterm delivery, and recurrent implantation failure. In this study, the impact of hysteroscopic metroplasty for a T/Y-shaped uterus on obstetric outcomes was investigated in patients with infertility and recurrent pregnancy loss (RPL) and compared the uterine anomaly subgroups.

Method: Cases with infertility and/or RPL diagnosed with T/Y-shaped uterus by hysterosalpingography (HSG) and 3D transvaginal ultrasonography (3D TVUSG) with no other male or female pathology have recruited the study. Read More

Comput Math Methods Med 2022 11;2022:4082266. Epub 2022 Jun 11.

Anhui Wannan Rehabilitation Hospital·Wuhu Fifth People's Department of Obstetrics and Gynecology, Anhui, Wuhu 241000, China.

Objective: A case-control study was performed to explore the efficacy and adverse reactions of Mirena combined with hysteroscopy when treating AUB.

Methods: 108 patients with perimenopausal AUB treated in our hospital from June 2019 to December 2021 were enrolled, and their clinical data were collected and analyzed retrospectively. According to the mode of treatment, the patients were assigned into control group (54 cases) and study group (54 cases). Read More

Fertil Steril 2022 Jul;118(1):19-28

Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland; Ludwin & Ludwin Gynecology, Private Medical Center, Krakow, Poland.

The high efficacy of modern assisted reproductive technology (ART) and increase in the number of noninfertile patients who are using ART for family building in the United States call into question the relevance of the standard, one-size-fits-all infertility evaluation. Here, we explore whether all patients presenting for ART need uterine cavity and tubal assessment and what tests are most appropriate, efficient, and cost-effective in current times. Read More

Int J Gen Med 2022 11;15:5609-5614. Epub 2022 Jun 11.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China.

Purpose: Nalbuphine is becoming a common analgesic used in hysteroscopic operations. The aim of this study was to identify the median effective dose (ED50) and 95% effective dose (ED95) of nalbuphine combined with propofol in painless hysteroscopy.

Patients And Methods: Twenty-five patients aged 18-60 years with an American Society of Anesthesiologists classification of I-II who were scheduled for painless hysteroscopy were recruited. Read More

Wideochir Inne Tech Maloinwazyjne 2022 Jun 17;17(2):380-384. Epub 2022 Feb 17.

Department of Obstetrics and Gynecology, Academic Hospital, Cologne Weyertal University of Cologne, Germany.

Introduction: The advantage of transcervical radiofrequency ablation (TRFA) is that it is minimally invasive, incision-free, and treats a wide spectrum of fibroids, including those that are not accessible by surgical hysteroscopy (FIGO 3, 4, 5, 6, and 2-5). However, there are no publications describing a combined procedure of operative hysteroscopy and TRFA yet, so it was still unknown whether a combined procedure is associated with additional risks.

Aim: To report the combined technique of transcervical intrauterine radiofrequency ablation of fibroids and surgical hysteroscopy. Read More

J Obstet Gynaecol Res 2022 Jun 15. Epub 2022 Jun 15.

Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital & University of Ottawa, Ottawa, Ontario, Canada.

Background: Failure to obtain an office-based endometrial biopsy for abnormal uterine bleeding is not uncommon. Although operating room-based procedures are traditionally considered the gold standard assessment tool in these circumstances, outpatient hysteroscopy is a less invasive, more cost-effective, and safer alternative. However, there is no contemporary Canadian literature on the effectiveness of an outpatient approach for this specific population. Read More

J Transl Int Med 2022 Mar 2;10(1):79-81. Epub 2022 Apr 2.

Department of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles (ULB), Brussels 1020, Belgium.

J Obstet Gynaecol Res 2022 Jun 13. Epub 2022 Jun 13.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.

Aim: To compare the efficacy and safety of in-office hysteroscopy with a see-and-treat approach with that of operative hysteroscopy for the treatment of retained products of conception (RPOC).

Methods: We retrospectively identified all consecutive patients who underwent hysteroscopic treatment of RPOC between 2015 and 2019. We excluded patients with RPOC larger than 2 cm at preoperative transvaginal ultrasounds. Read More

J Minim Invasive Gynecol 2022 Jun 10. Epub 2022 Jun 10.

AP-HP, GHU-Sud, Hospital Bicêtre, Department of Gynecology and Obstetrics, 78 rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.; Faculty of medicine, University Paris-Sud Saclay, 63 rue Gabriel Péri, 94270 Le Kremlin Bicêtre, France.; Université Paris-Saclay, UVSQ, Inserm, CESP, 94807, Villejuif, France.. Electronic address:

Institutional Review Board: An IRB is not required in France, but the patient agreed to the study and gave her approval to publish the images. The study, including retrospective review of images, was approved by the French Data Protection Authority (Commission Nationale de l'Informatique et des Libertés) No. 1181076. Read More

Fertil Steril 2022 Jun 9. Epub 2022 Jun 9.

Reproductive Medicine Center, Northwest Women's and Children's Hospital, Xi'an, People's Republic of China. Electronic address:

Objective: To investigate whether cured chronic endometritis (CE) from antibiotic treatment would be associated with a higher risk of spontaneous abortion in the following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.

Design: Prospective cohort study.

Setting: Tertiary reproductive medicine center. Read More

Fertil Steril 2022 Jun 9. Epub 2022 Jun 9.

Department of Gynecology and Obstetrics, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai, Zhejiang Province, People's Republic of China. Electronic address:

Objective: To study the efficacy of 3 treatment options for type 2 cesarean scar pregnancy (CSP) and establish an optimal treatment strategy for type 2 CSP.

Design: Retrospective cohort study.

Setting: A tertiary hospital. Read More

Arch Gynecol Obstet 2022 Jun 9. Epub 2022 Jun 9.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montréal, QC, H3A 0G4, Canada.

Purpose: To evaluate whether different measurements of endometrial thickness pre-IVF cycle and during the IVF cycles as measured by transvaginal ultrasound are associated with the absence or presence of endometrial polyps.

Design: A retrospective cohort study was conducted in a university-affiliated fertility center. Patients were women who underwent two embryo transfer cycles and failed to conceive. Read More

Rom J Morphol Embryol 2021 Oct-Dec;62(4):961-969

Department of Immunology, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania;

Background: The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because the choice of the anesthetic agent can influence the patient's immune system.

Aim: Evaluation of the effect of anesthetic drugs used for total intravenous anesthesia (Propofol and Midazolam) on the inflammatory response after minimally invasive gynecological surgery. Read More

Comput Intell Neurosci 2022 27;2022:6951692. Epub 2022 May 27.

Department of B-ultrasound Imaging, The Fourth Hospital of Changsha, Changsha 410006, Hunan, China.

In order to explore the diagnostic value of the improved clustering algorithm of vaginal ultrasound combined with hysteroscopy in abnormal uterine bleeding (AUB), 128 patients diagnosed with AUB in the hospital were selected as the research objects. A -means improved clustering color image segmentation algorithm was designed and applied to AUB vaginal ultrasound image processing. The running time, mean square error (MSE), and peak to signal noise ratio (PSNR) were calculated to evaluate the algorithm, and the sensitivity, specificity, negative likelihood ratio, and positive likelihood ratio were used to evaluate the diagnostic accuracy of the detection method. Read More

J Gynecol Obstet Hum Reprod 2022 Jun 3;51(8):102417. Epub 2022 Jun 3.

Department of Obstetrics and Gynecology, Jinhua Municipal Central Hospital, Jinhua, China. Electronic address:

Study Objective: This study compared the efficacy and safety of a combination of uterine artery embolization or methotrexate before hysteroscopy in the treatment of cesarean scar pregnancy.

Methods: We divided 276 cesarean scar pregnancy patients into three groups. Group A underwent direct hysteroscopy; Group B received uterine artery embolization plus hysteroscopy; Group C received the systemic administration of methotrexate prior to hysteroscopy. Read More

Am J Obstet Gynecol 2022 Jun 3. Epub 2022 Jun 3.

Department of Obstetrics and Gynecology, Lariboisière Hospital, Public Assistance Hospitals of Paris, Paris, France.

Background: Miscarriage is a frequent problem that requires dilation and curettage in 30% of cases. This routine surgery may lead to intrauterine adhesions and severe infertility. Hyaluronic acid gel is known to reduce intrauterine adhesions after hysteroscopic surgery. Read More

Climacteric 2022 Jun 2:1-6. Epub 2022 Jun 2.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, USA.

Objective: We gained insights into women's experiences and knowledge about the occurrence of vaginal bleeding during perimenopause requiring evaluation.

Methods: Qualitative inquiry was chosen to explore topics in greater depth to understand individuals' experiences. Interviews with individuals were chosen due to the sensitive nature of gynecologic symptoms and management. Read More

Curr Opin Obstet Gynecol 2022 06;34(3):107-113

Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose Of Review: To succinctly review the basic mechanisms of implantation and luteal phase endometrial differentiation, the etiologies of impaired endometrial function and receptivity, and the current methods that exist to evaluate and treat impaired endometrial receptivity.

Recent Findings: Human embryo implantation requires bidirectional communication between blastocyst and a receptive endometrium. Etiologies of impaired endometrial receptivity are varied. Read More

Obstet Gynecol Clin North Am 2022 Jun;49(2):329-353

Minimally Invasive Gynecologic Surgery, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.

Hysteroscopic myomectomy is the treatment of choice for symptomatic submucosal myomas, with excellent success rate and low complication rate. Read More

Obstet Gynecol Clin North Am 2022 Jun;49(2):315-327

Women's and Infants' Services, Minimally Invasive Gynecologic Surgery, MedStar Washington Hospital Center, 106 Irving Street, Northwest Suite 405 South, Washington, DC 20010, USA. Electronic address:

Office hysteroscopy is a highly effective procedure for the evaluation and treatment of intrauterine pathology. The "see and treat" approach allows for patient treatment with the fewest amount of patient visits. The development of smaller cameras and instruments, as well as the employment of a vaginoscopy technique, has led to greater tolerability of office hysteroscopy and significant success of the "see and treat" approach. Read More

J Coll Physicians Surg Pak 2022 Apr;32(4):S18-S20

Department of Anesthesiology, The First Hospital of Jilin University, Xinmin Street, Changchun, Jilin, China.

Uterine adenosarcoma is a rare tumor composed of benign epithelium in combination with malignant mesenchymal components. Misdiagnosis is common due to the lack of specific clinical manifestations and the rarity of such tumors in young age groups. The mean age at diagnosis is 58. Read More

Diagnostics (Basel) 2022 May 9;12(5). Epub 2022 May 9.

Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.

Abnormal uterine bleeding (AUB) is a frequent symptom in perimenopausal women. It is defined as uterine bleeding in which the duration, frequency, or amount of bleeding is considered excessive and negatively affects the woman's quality of life (QoL) and psychological well-being. In cases of structural uterine pathology, hysterectomy (usually performed via a minimally invasive approach) offers definitive symptom relief and is associated with long-lasting improvement of QoL and sexuality. Read More