7,960 results match your criteria Hypoxic-Ischemic Encephalopathy


[Neonatal hypoxia-ischemia: cellular and molecular brain damage and therapeutic modulation of neurogenesis].

Rev Neurol 2019 Jan;68(1):23-36

Universidad del Pais Vasco, Leioa, Espana.

Introduction: Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability. The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective. Read More

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January 2019

Novel Quantitative Contrast-Enhanced Ultrasound Detection of Hypoxic Ischemic Injury in Neonates and Infants: Pilot Study 1.

J Ultrasound Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objectives: To investigate whether quantitative contrast-enhanced ultrasound (CEUS) can accurately identify neonates and infants with hypoxic ischemic brain injury.

Methods: In this prospective cohort study, 8 neonates and infants with a suspicion of hypoxic ischemic injury were evaluated with CEUS.

Results: An interesting trend was observed in the central gray nuclei-to-cortex perfusion ratios. Read More

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http://dx.doi.org/10.1002/jum.14892DOI Listing
December 2018

δ-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy.

Mol Neurobiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurosurgery, The University of Texas McGovern Medical School, Houston, TX, USA.

Neonatal hypoxic-ischemic encephalopathy (HIE) causes serious neurological disability; there are, however, currently few promising therapies for it. We have recently shown that δ-opioid receptor (DOR) is neuroprotective by downregulating TNF-α. Since hypoxia-ischemia (HI) triggers a robust inflammatory response, which exacerbates HI brain damage, we investigated, in this study, whether DOR activation could regulate inflammatory cytokine expression, thereby playing a protective effect on the neonatal brain under HI. Read More

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http://dx.doi.org/10.1007/s12035-018-1452-7DOI Listing
December 2018

Administration of Bone Marrow-Derived Mononuclear Cells Contributed to the Reduction of Hypoxic-Ischemic Brain Injury in Neonatal Rats.

Front Neurol 2018 30;9:987. Epub 2018 Nov 30.

Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Perinatal hypoxic-ischemia (HI) causes neonatal death and permanent neurological deficits. Cell therapy using various cell sources has been recently identified as a novel therapy for perinatal HI. Among the available types of cell sources, bone marrow-derived mononuclear cells (BMMNCs) have unique features for clinical application. Read More

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http://dx.doi.org/10.3389/fneur.2018.00987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284369PMC
November 2018

Downregulation of the Vitamin D Receptor Regulated Gene Set in the Hippocampus After MDMA Treatment.

Front Pharmacol 2018 3;9:1373. Epub 2018 Dec 3.

Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.

The active ingredient of ecstasy, ±3,4-methylenedioxymethamphetamine (MDMA), in addition to its initial reinforcing effects, induces selective and non-selective brain damage. Evidences suggest that the hippocampus (HC), a central region for cognition, may be especially vulnerable to impairments on the long-run, nevertheless, transcription factors that may precede and regulate such chronic changes remained uninvestigated in this region. In the current study, we used gene-set enrichment analysis (GSEA) to reveal possible transcription factor candidates responsible for enhanced vulnerability of HC after MDMA administration. Read More

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http://dx.doi.org/10.3389/fphar.2018.01373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287013PMC
December 2018

Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy.

Pediatr Neurol 2018 Nov 23. Epub 2018 Nov 23.

Children's Hospitals Neonatal Consortium, Kansas City, MO.

Purpose: We describe the frequency and timing of withdrawal of life-support (WLS) in moderate or severe hypoxic-ischemic encephalopathy (HIE) and examine its associations with medical and sociodemographic factors.

Procedures: We undertook a secondary data analysis of a prospective multicenter data registry of regional level IV Neonatal Intensive Care Units participating in the Children's Hospitals Neonatal Database. Infants ≥36 weeks gestational age with HIE admitted to a Children's Hospitals Neonatal Database Neonatal Intensive Care Unit between 2010 and 2016, who underwent therapeutic hypothermia were categorized as (1) infants who died following WLST and (2) survivors with severe HIE (requiring tube feedings at discharge). Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.08.027DOI Listing
November 2018

A Pilot Study of Soluble Form of LOX-1 as a Novel Biomarker for Neonatal Hypoxic-Ischemic Encephalopathy.

J Pediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address:

Objective: To evaluate the soluble form of lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) as a biomarker of severity staging and prognosis in neonatal hypoxic-ischemic encephalopathy (HIE).

Study Design: We performed an observational study enrolling 27 infants with HIE and 45 control infants of gestational age ≥36 weeks and birth weight ≥1800 g. The HIE criteria were pH ≤7. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.10.036DOI Listing
December 2018
1 Read

Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676052
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http://dx.doi.org/10.1055/s-0038-1676052DOI Listing
December 2018
2 Reads

Pediatric encephalic ultrasonography: the essentials.

J Ultrasound 2018 Dec 14. Epub 2018 Dec 14.

Radiology Department, "Santobono-Pausilipon" Children Hospital, Naples, Italy.

Nowadays, cranial ultrasonography (US) of the newborn represents the first imaging method in brain damage study and its possible outcomes. This exam is performed using the natural fontanelles, especially the anterior one. It is fast, non-invasive and does not produce any side effect. Read More

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http://dx.doi.org/10.1007/s40477-018-0349-7DOI Listing
December 2018

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.007DOI Listing
November 2018

A nationwide survey on tracheostomy for very-low-birth-weight infants in Japan.

Pediatr Pulmonol 2019 Jan 7;54(1):53-60. Epub 2018 Dec 7.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: Tracheostomy is indicated for very-low-birth-weight infants (VLBWIs) with prolonged respiratory problems during the perinatal period. The objective of this study is to clarify the epidemiology and risk factors in VLBWIs with tracheostomy after birth in Japan.

Methods: A total of 40 806 VLBWIs were registered in the Neonatal Research Network of Japan database from 2003 to 2012. Read More

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http://dx.doi.org/10.1002/ppul.24200DOI Listing
January 2019

Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling.

J Perinat Med 2018 Dec 7. Epub 2018 Dec 7.

Pediatrics, Division of Neonatology, New York University Medical Center, New York, NY, USA.

Background Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature. Read More

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http://dx.doi.org/10.1515/jpm-2018-0302DOI Listing
December 2018

Early-Stage Translational Research in Perinatal Medicine.

Neonatology 2018 Dec 6;115(2):182-188. Epub 2018 Dec 6.

Liggins Institute, University of Auckland, Auckland, New

Background: Pre-clinical research, which encompasses studies in animals and in the laboratory, has made significant contributions to the improvement of neonatal outcomes.

Methods: Here, we describe examples of how pre-clinical research can be the starting point on the journey to the development of new interventions to improve neonatal care and outcomes and discuss recent progress in ensuring methodological and ethical rigour in pre-clinical research involving animal models.

Results: Studies in pregnant sheep led to the serendipitous discovery that preterm lambs born after exogenous corticosteroid exposure were able to aerate their lungs. Read More

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https://www.karger.com/Article/FullText/493004
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http://dx.doi.org/10.1159/000493004DOI Listing
December 2018
7 Reads

Late initiation of therapeutic hypothermia: not the new standard of care.

Acta Paediatr 2018 Dec 2. Epub 2018 Dec 2.

Department of Pediatrics, Section of Neonatology, University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1111/apa.14671DOI Listing
December 2018
1 Read

Extracting Interesting Rules from Gestation Course Data for Early Diagnosis of Neonatal Hypoxia.

J Med Syst 2018 Dec 1;43(1). Epub 2018 Dec 1.

Volodymyr Dahl East Ukrainian National University, Severodonetsk, Ukraine.

The topic of neonatal hypoxia is of paramount importance to anyone who cares during pregnancy and childbirth. Modern medicine associates this pathology with severe problems in the prenatal period. Underlying diseases of the mother during pregnancy, her anamnesis of life are the leading causes of complications in the newborn. Read More

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http://dx.doi.org/10.1007/s10916-018-1125-0DOI Listing
December 2018
2 Reads

Delayed cortical blindness in hypoxic-ischemic encephalopathy.

eNeurologicalSci 2018 Dec 19;13:33-34. Epub 2018 Nov 19.

Department of Internal Medicine, Inha University Hospital, Incheon, Republic of Korea.

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http://dx.doi.org/10.1016/j.ensci.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251780PMC
December 2018

Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial?

Endocr Metab Immune Disord Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

Departments of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Gharbia. Egypt.

Background: Neonatal hypoxic ischemic encephalopathy (HIE) is a potentially devastating disorder associated with significant mortality and long-term morbidity.

Aim Of The Study: The aim of this study was to study the role of vitamin D as an adjuvant therapy for management of neonatal HIE.

Patients And Methods: This study was carried out on 60 neonates with HIE grade II who were diagnosed according to modified Sarnat staging and were divided in to 2 groups: Group I: Included 30 neonates with Sarnat grade II HIE who received single daily oral dose of vitamin D3 (1000 IU) for 2 weeks in addition to daily subcutaneous (SC) human recombinant erythropoietin (2500 IU/kg) for 5 days and IM or IV magnesium sulphate 250 mg/kg within half an hour of birth, and subsequently 125 mg/kg at 24 and 48 hours of life. Read More

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http://dx.doi.org/10.2174/1871530319666181204151044DOI Listing
December 2018
2 Reads

Risk management and provider liabilities in infantile cerebral palsy based on malpractice litigation cases.

J Forensic Leg Med 2018 Nov 25;61:82-88. Epub 2018 Nov 25.

Shanghai Jiao Tong University School of Public Health, China Hospital Development Institute of Shanghai Jiao Tong University, China. Electronic address:

Aim: Infantile cerebral palsy (CP) severely affects the survival and quality of life of infants. CP is typically caused by multiple factors, leading to causal uncertainty of the role of medical errors in CP and resulting in frequent medical disputes. No relevant research exists on risk management and malpractice liabilities in CP, including in China. Read More

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http://dx.doi.org/10.1016/j.jflm.2018.11.010DOI Listing
November 2018
2 Reads

Preventive and therapeutic effects of environmental enrichment in Wistar rats submitted to neonatal hypoxia-ischemia.

Behav Brain Res 2018 Nov 26;359:485-497. Epub 2018 Nov 26.

Post-Graduation Program of Physiology, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Department of Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Environmental enrichment (EE) at early stages of neurodevelopment attenuates HI-induced behavioral, histological and cellular damage. However, the effects of EE exposure during gestational or early postnatal period and the possible influence of sexual dimorphism on EE protection are not fully understood. Present study evaluated the effects of pre-natal and postnatal EE, as well as their combination, in male and female rats submitted to neonatal HI at postnatal day (PND) 3. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.11.036DOI Listing
November 2018
1 Read

The Superior Function of the Subplate in Early Neocortical Development.

Front Neuroanat 2018 14;12:97. Epub 2018 Nov 14.

Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

During early development the structure and function of the cerebral cortex is critically organized by subplate neurons (SPNs), a mostly transient population of glutamatergic and GABAergic neurons located below the cortical plate. At the molecular and morphological level SPNs represent a rather diverse population of cells expressing a variety of genetic markers and revealing different axonal-dendritic morphologies. Electrophysiologically SPNs are characterized by their rather mature intrinsic membrane properties and firing patterns. Read More

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http://dx.doi.org/10.3389/fnana.2018.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246655PMC
November 2018

MR Imaging of hypoxic ischemic encephalopathy - Distribution Patterns and ADC value correlations.

Eur J Radiol Open 2018 16;5:215-220. Epub 2018 Nov 16.

Department of Radio-diagnosis, Dr RPGMC, Kangra, Tanda, Himachal Pradesh, India.

Background And Purpose: Neonatal hypoxic-ischemic encephalopathy causes hypoxic brain injury. Due to differences in brain maturity at time of insult, severity of hypotension and duration of insult, there are four distinct patterns of brain injury. Magnetic resonance imaging is the most sensitive modality for evaluating these patterns of brain injury. Read More

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http://dx.doi.org/10.1016/j.ejro.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240807PMC
November 2018
1 Read

Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic-ischemic encephalopathy.

J Cell Biochem 2018 Nov 26. Epub 2018 Nov 26.

Department of Pediatric, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, China.

Long noncoding RNAs (lncRNAs) have been shown to participate in many biological processes. To investigate the expression profiles of lncRNAs and their potential functions in neonatal hypoxic-ischemic encephalopathy (HIE), we detected the lncRNA and messenger RNA (mRNA) expression in the peripheral blood samples from HIE patients and controls using a microarray. A total of 376 lncRNAs and 126 mRNAs were differentially expressed between the HIE and the non-HIE samples (fold change > 2). Read More

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http://dx.doi.org/10.1002/jcb.28138DOI Listing
November 2018

Another Case of Multilevel Cervical Disconnection Syndrome Presenting as Neonatal Encephalopathy.

Case Rep Neurol Med 2018 24;2018:7908753. Epub 2018 Oct 24.

Division of Pediatric Hospitalist Medicine, Department of Pediatrics, Staten Island University Hospital-Northwell Health, Staten Island, NY, USA.

Multilevel cervical disconnection syndrome (MCDS) is a rare malformation of the cervical spine previously documented in two toddlers. We present a case of a newborn first thought to have hypoxic-ischemic encephalopathy who was subsequently diagnosed with MCDS. The possibility of in utero presentation of the syndrome in this patient and the categorization of this syndrome in the spectrum of basilar skull/upper cervical malformation syndromes is discussed. Read More

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http://dx.doi.org/10.1155/2018/7908753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220399PMC
October 2018

Rhythmic Sawtooth Electroencephalograph Waveforms in Neonatal Hypoxic-Ischemic/Hypoglycemic Encephalopathy.

Pediatr Neurol 2018 Oct 24. Epub 2018 Oct 24.

Research Institute of the McGill University Health Center, Montreal, Quebec, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.010DOI Listing
October 2018
1 Read

Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience.

Arch Dis Child Fetal Neonatal Ed 2018 Nov 24. Epub 2018 Nov 24.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork, Ireland.

Objective: The aim of this multicentre study was to describe detailed characteristics of electrographic seizures in a cohort of neonates monitored with multichannel continuous electroencephalography (cEEG) in 6 European centres.

Methods: Neonates of at least 36 weeks of gestation who required cEEG monitoring for clinical concerns were eligible, and were enrolled prospectively over 2 years from June 2013. Additional retrospective data were available from two centres for January 2011 to February 2014. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315624DOI Listing
November 2018
3 Reads

Geniposide protects PC-12 cells against oxygen and glucose deprivation-induced injury by up-regulation of long-noncoding RNA H19.

Life Sci 2019 Jan 22;216:176-182. Epub 2018 Nov 22.

Department of Children Rehabilitation, Jining No.1 People's Hospital, Jining 272011, China; Jining No.1 People's Hospital of Jining Medical University, Jining Medical University, Jining 272000, China. Electronic address:

Aims: Hypoxic-ischemic encephalopathy (HIE) is a common brain injury disease in neonates, which can lead to neonatal disability and death. Geniposide (GEN) is a main ingredient of Gardenia jasminoides, whose anti-tumor, anti-inflammatory and anti-apoptotic effects have been reported in various diseases. However, the effect of GEN on HIE remains uninvestigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183076
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http://dx.doi.org/10.1016/j.lfs.2018.11.047DOI Listing
January 2019
9 Reads

Neuroprotection by cannabidiol and hypothermia in a piglet model of newborn hypoxic-ischemic brain damage.

Neuropharmacology 2018 Nov 20;146:1-11. Epub 2018 Nov 20.

Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain; Servicio de Neonatología, Hospital Clínico San Carlos - IdISSC, Madrid, Spain. Electronic address:

Objective: Hypothermia, the gold standard after a hypoxic-ischemic insult, is not beneficial in all treated newborns. Cannabidiol is neuroprotective in animal models of newborn hypoxic-ischemic encephalopathy. This study compared the relative efficacies of cannabidiol and hypothermia in newborn hypoxic-ischemic piglets and assessed whether addition of cannabidiol augments hypothermic neuroprotection. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.11.020DOI Listing
November 2018
5 Reads

Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway.

Pharm Biol 2018 Dec;56(1):440-449

a Department of Neurology , Shengjing Hospital Affiliated Hospital of China Medical University , Shenyang, Liaoning , China.

Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate. Resveratrol possesses numerous biological properties including antioxidant, anti-inflammatory and neuroprotective activities.

Objective: The current experiment investigates the neuroprotective efficacy of resveratrol (RESV) against HIE by modulating Nrf2/HO-1 pathway in neonatal rats. Read More

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http://dx.doi.org/10.1080/13880209.2018.1502326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249550PMC
December 2018
2 Reads

Review of diffuse cortical injury on diffusion-weighted imaging in acutely encephalopathic patients with an acronym: "CRUMPLED".

Eur J Radiol Open 2018 9;5:194-201. Epub 2018 Nov 9.

Department of Radiology, Division of Neuroradiology, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose: Acute encephalopathic syndromes can present a diagnostic challenge due to the wide range of possible etiologies, which also can have vastly different outcomes. The presence of diffuse cortical injury (DCI) on diffusion-weighted imaging (DWI) can help narrow the differential diagnosis. The aim of this review is to categorize the range of possible etiologies of DCI into a useful acronym, "CRUMPLED". Read More

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http://dx.doi.org/10.1016/j.ejro.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231053PMC
November 2018
5 Reads

Magnetic Resonance Imaging Findings of Term and Preterm Hypoxic-Ischemic Encephalopathy: A Review of Relevant Animal Models and Correlation to Human Imaging.

Open Neuroimag J 2018 17;12:55-65. Epub 2018 Oct 17.

Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States.

Background: Neonatal hypoxic-ischemic encephalopathy is brain injury caused by decreased perfusion and oxygen delivery that most commonly occurs in the context of delivery complications such as umbilical cord compression or placental abruption. Imaging is a key component for guiding treatment and prediction of prognosis, and the most sensitive clinical imaging modality for the brain injury patterns seen in hypoxic-ischemic encephalopathy is magnetic resonance imaging.

Objective: The goal of this review is to compare magnetic resonance imaging findings demonstrated in the available animal models of hypoxic-ischemic encephalopathy to those found in preterm (≤ 36 weeks) and term (>36 weeks) human neonates with hypoxic-ischemic encephalopathy, with special attention to the strengths and weaknesses of each model. Read More

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http://benthamopen.com/FULLTEXT/TONIJ-12-55
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http://dx.doi.org/10.2174/1874440001812010055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198416PMC
October 2018
2 Reads

Intrapartum cardiotocography with and without computer analysis: a systematic review and meta-analysis of randomized controlled trials.

J Matern Fetal Neonatal Med 2018 Nov 18:1-7. Epub 2018 Nov 18.

f Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Sidney Kimmel Medical College of Thomas Jefferson University , Philadelphia , PA , USA.

Objective: To evaluate whether intrapartum cardiotocography with computer analysis decreases the incidence of newborn metabolic acidosis or obstetric intervention when compared with visual analysis through a systematic review with meta-analysis of randomized controlled trials.

Methods: The research was conducted using Medline, Embase, Web of Science, Scopus, ClinicalTrial.gov, Ovid and Cochrane Library as electronic databases from the inception of each database to May 2018. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1542676DOI Listing
November 2018
6 Reads

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats.

Brain Res 2018 Nov 15. Epub 2018 Nov 15.

Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 107, 90050- 170, Porto Alegre, RS, Brazil; Departamento de Ciências Morfológicas. Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050- 170, Porto Alegre, RS, Brazil. Electronic address:

The aim of this study was to evaluated motor function and morphological aspects of the components involved in motor control (sensorimotor cortex, spinal cord, sciatic nerve, neuromuscular junctions and skeletal muscle) in male Wistar rats exposed to a model of neonatal hypoxic-ischemic encephalopathy (HIE) and the possible influence of different physical exercise protocols - treadmill and acrobatic. Male Wistar rats at the 7 post-natal day (PND) were submitted to the HIE model and from the 22 until 60 PND the exercise protocols (treadmill or acrobatic training) were running. After the training, the animals were evaluated in Open Field, Ladder Rung Walking and Rotarod tasks and after samples of the motor control components were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183057
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http://dx.doi.org/10.1016/j.brainres.2018.11.021DOI Listing
November 2018
3 Reads

Neonatal Encephalopathy: Current Management and Future Trends.

Crit Care Nurs Clin North Am 2018 Dec;30(4):509-521

Overland Park Regional Medical Center, NICU, 10500 Quivira Road, Overland Park, KS 66215, USA. Electronic address:

It is well-documented in the literature that infants who suffer from hypoxic ischemic encephalopathy are at high risk for neurologic sequelae or even death. With the addition of therapeutic hypothermia into the treatment regimen for neonatal hypoxic ischemic encephalopathy, newborns afflicted with hypoxic ischemic encephalopathy were given the opportunity for a better outcome. Questions linger as to the most optimal treatment strategy of therapeutic hypothermia for these newborns. Read More

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http://dx.doi.org/10.1016/j.cnc.2018.07.007DOI Listing
December 2018
1 Read

Targeting low-normal or high-normal mean arterial pressure after cardiac arrest and resuscitation: a randomised pilot trial.

Intensive Care Med 2018 Dec 15;44(12):2091-2101. Epub 2018 Nov 15.

Department of Intensive Care, North Karelia Central Hospital, Joensuu, Finland.

Purpose: We aimed to determine the feasibility of targeting low-normal or high-normal mean arterial pressure (MAP) after out-of-hospital cardiac arrest (OHCA) and its effect on markers of neurological injury.

Methods: In the Carbon dioxide, Oxygen and Mean arterial pressure After Cardiac Arrest and REsuscitation (COMACARE) trial, we used a 2 factorial design to randomly assign patients after OHCA and resuscitation to low-normal or high-normal levels of arterial carbon dioxide tension, to normoxia or moderate hyperoxia, and to low-normal or high-normal MAP. In this paper we report the results of the low-normal (65-75 mmHg) vs. Read More

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http://link.springer.com/10.1007/s00134-018-5446-8
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http://dx.doi.org/10.1007/s00134-018-5446-8DOI Listing
December 2018
5 Reads

Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial.

Intensive Care Med 2018 Dec 14;44(12):2112-2121. Epub 2018 Nov 14.

Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: We assessed the effects of targeting low-normal or high-normal arterial carbon dioxide tension (PaCO) and normoxia or moderate hyperoxia after out-of-hospital cardiac arrest (OHCA) on markers of cerebral and cardiac injury.

Methods: Using a 2 factorial design, we randomly assigned 123 patients resuscitated from OHCA to low-normal (4.5-4. Read More

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http://link.springer.com/10.1007/s00134-018-5453-9
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http://dx.doi.org/10.1007/s00134-018-5453-9DOI Listing
December 2018
5 Reads

Prediction of adverse perinatal outcomes by the cerebroplacental ratio in women undergoing induction of labour.

Ultrasound Obstet Gynecol 2018 Nov 13. Epub 2018 Nov 13.

Fetal Medicine Research Institute, King's College Hospital, London, UK.

Objective: To investigate the performance of screening for adverse perinatal outcome by the cerebroplacental ratio (CPR) measured within 24 hours of induction of labor.

Methods: This was a prospective observational study in 1,902 singleton pregnancies undergoing induction of labor at ≥ 37 weeks' gestation. Doppler ultrasound was used to measure the pulsatility index (PI) in the umbilical artery (UA) and fetal middle cerebral artery (MCA) before induction of labor. Read More

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http://dx.doi.org/10.1002/uog.20173DOI Listing
November 2018
1 Read

Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced brain injury on MR biomarkers in mild hypoxic-ischaemic encephalopathy: a non-randomised cohort study.

Arch Dis Child Fetal Neonatal Ed 2018 Nov 13. Epub 2018 Nov 13.

Centre for Perinatal Neuroscience, Imperial College London, London, UK.

Objective: To examine the effect of therapeutic hypothermia on MR biomarkers and neurodevelopmental outcomes in babies with mild hypoxic-ischaemic encephalopathy (HIE).

Design: Non-randomised cohort study.

Setting: Eight tertiary neonatal units in the UK and the USA. Read More

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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2018-31604
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http://dx.doi.org/10.1136/archdischild-2018-316040DOI Listing
November 2018
7 Reads

Child Abuse, Incarceration, and Decisions About Life-sustaining Treatment.

Pediatrics 2018 Dec 8;142(6). Epub 2018 Nov 8.

Center for Bioethics, Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri

Most critical care interventions for children occur in the framework of a supportive environment with loving parents that are present at the bedside to help to guide medical interventions through shared decision-making. What happens, however, if the parents are precluded from being at the bedside because of legal entanglements? How should clinical decisions progress in those cases? In this Ethics Rounds, we present the case of an infant with severe hypoxic-ischemic encephalopathy at birth whose mother was incarcerated shortly after delivery. We explore clinical and legal challenges that the medical team faces in determining best interests for the infant in this context and difficulties in deciding what therapies to provide and for how long. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-0430DOI Listing
December 2018
6 Reads

Comment on "Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment" in a cerebral hypoxia-ischemia mice model.

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6573-6574

Université Sorbonne of Paris, Paris, France.

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October 2018
3 Reads

Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: a feasibility study using magnetic resonance imaging.

Pediatr Radiol 2018 Nov 6. Epub 2018 Nov 6.

Department of Pediatrics (Neonatal-Perinatal Medicine), Department of Obstetrics and Gynecology, Penn State Health Children's Hospital, Hershey, PA, USA.

Background: Therapeutic hypothermia is the standard-of-care treatment for infants diagnosed with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). MRI for assessing brain injury is usually performed after hypothermia because of logistical challenges in bringing acutely sick infants receiving hypothermia from the neonatal intensive care unit (NICU) to the MRI suite. Perhaps examining and comparing early cerebral oxygen metabolism disturbances to those after rewarming will lead to a better understanding of the mechanisms of brain injury in HIE and the effects of therapeutic hypothermia. Read More

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http://dx.doi.org/10.1007/s00247-018-4283-9DOI Listing
November 2018
1 Read

"Black Toenail" Sign.

Pediatr Neurol 2018 Sep 21. Epub 2018 Sep 21.

Division of Pediatric Neurology, The University of Tennessee Health Science Center, Memphis, Tennessee.

A 11-year-old boy with genetically confirmed MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome with mutation at mt.3243A>G) presented with extreme fatigue. Upon presentation, he had elevated lactic acid of 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183065
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.07.011DOI Listing
September 2018
8 Reads

Diagnostic performance of CT densities in selected gray- and white-matter regions for the clinical diagnosis of brain death: A retrospective study in a tertiary-level general hospital.

Eur J Radiol 2018 Nov 19;108:66-77. Epub 2018 Sep 19.

Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico. Electronic address:

Introduction: We aimed to determine the diagnostic performance of Hounsfield Units (HUs) in selected brain region using computed tomography for the clinical diagnosis of brain death (BD).

Methods: A retrospective, case-control study design. A total of 66 subjects (22 cases, 44 controls) underwent brain tomography between January 2011 and December 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.023DOI Listing
November 2018
4 Reads

Symptomatic seizures in preterm newborns: a review on clinical features and prognosis.

Ital J Pediatr 2018 Nov 1;44(1):115. Epub 2018 Nov 1.

Child Neuropsychiatry Unit, Medicine & Surgery Department, Neuroscience Division, University of Parma, Parma, Italy.

Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular haemorrhage, hypoxic-ischemic encephalopathy, central nervous system infections and transient metabolic derangements.Current definition of neonatal seizures requires detection of paroxysmal EEG-changes, and in preterm newborns the incidence of electrographic-only seizures seems to be particularly high, further stressing the crucial role of electroencephalogram monitoring in this population. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0573-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211591PMC
November 2018
2 Reads

Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy".

Early Hum Dev 2018 Oct 29. Epub 2018 Oct 29.

Division of Neonatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, United States of America.

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.014DOI Listing
October 2018
1 Read

Peripheral myeloid cells contribute to brain injury in male neonatal mice.

J Neuroinflammation 2018 Oct 30;15(1):301. Epub 2018 Oct 30.

Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, SE-405 30, Gothenburg, Sweden.

Background: Neonatal brain injury is increasingly understood to be linked to inflammatory processes that involve specialised CNS and peripheral immune interactions. However, the role of peripheral myeloid cells in neonatal hypoxic-ischemic (HI) brain injury remains to be fully investigated.

Methods: We employed the Lys-EGFP-ki mouse that allows enhanced green fluorescent protein (EGFP)-positive mature myeloid cells of peripheral origin to be easily identified in the CNS. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1344-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208095PMC
October 2018
1 Read

Central nervous system-active drug abused and overdose in children: a worldwide exploratory study using the WHO pharmacovigilance database.

Eur J Pediatr 2018 Oct 29. Epub 2018 Oct 29.

Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences L. Sacco, "Luigi Sacco" University Hospital, Università di Milano, 20157, Milan, Italy.

Recent epidemiological studies have reported an increase in central nervous system (CNS)-active drug abuse rates in paediatric settings, raising several public health concerns. No study to date has explored this issue worldwide. We performed an extensive analysis of drugs abuse/overdose reported for children in the last decade by using the largest pharmacovigilance database, i. Read More

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http://link.springer.com/10.1007/s00431-018-3281-0
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http://dx.doi.org/10.1007/s00431-018-3281-0DOI Listing
October 2018
2 Reads

Risk Factors for Seizures Among Young Children Monitored With Continuous Electroencephalography in Intensive Care Unit: A Retrospective Study.

Front Pediatr 2018 15;6:303. Epub 2018 Oct 15.

Children's Healthcare of Atlanta, Atlanta, GA, United States.

cEEG is an emerging technology for which there are no clear guidelines for patient selection or length of monitoring. The purpose of this study was to identify subgroups of pediatric patients with high incidence of seizures. We conducted a retrospective study on 517 children monitored by cEEG in the intensive care unit (ICU) of a children's hospital. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00303/
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http://dx.doi.org/10.3389/fped.2018.00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196272PMC
October 2018
5 Reads

Seizures in newborn infants without hypoxic ischemic encephalopathy - antenatal and labor-related risk factors: a case-control study.

J Matern Fetal Neonatal Med 2018 Oct 29:1-7. Epub 2018 Oct 29.

b Department of Women's and Children's Health , Uppsala University , Uppsala , Sweden.

Objective: To identify antepartum and intrapartum risk factors for neonatal seizures in the absence of hypoxic ischemic encephalopathy (HIE).

Methods: Population-based case-control study. Of 98 484 births, 40 newborns at 34 gestational weeks or later had seizures within the first 7 days of life. Read More

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http://dx.doi.org/10.1080/14767058.2018.1505853DOI Listing
October 2018
1 Read

Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets.

J Am Heart Assoc 2018 Oct;7(20):e009415

1 Department of Anesthesiology and Critical Care Medicine Johns Hopkins University Baltimore MD.

Background Neurological deficits in hypoxic-ischemic encephalopathy, even with therapeutic hypothermia, are partially attributed to white matter injury. We theorized that proteasome insufficiency contributes to white matter injury. Methods and Results Neonatal piglets received hypoxia-ischemia ( HI ) or sham procedure with normothermia, hypothermia, or hypothermia+rewarming. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009415
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http://dx.doi.org/10.1161/JAHA.118.009415DOI Listing
October 2018
5 Reads

Vitamin D3 deficiency in puberty rats causes presynaptic malfunctioning through alterations in exocytotic release and uptake of glutamate/GABA and expression of EAAC-1/GAT-3 transporters.

Food Chem Toxicol 2018 Oct 25;123:142-150. Epub 2018 Oct 25.

Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha str, Kiev, 01030, Ukraine. Electronic address:

Recent experimental and epidemiologic investigations have revealed that the central nervous system is a target for vitamin D3 action and also linked vitamin D3 deficiency to Alzheimer's and Parkinson's disease, autism and dementia. Abnormal homeostasis of glutamate and GABA and signaling disbalance are implicated in the pathogenesis of major neurological diseases. Here, key transport characteristics of glutamate and GABA were analysed in presynaptic nerve terminals (synaptosomes) isolated from the cortex of vitamin D3 deficient (VDD) rats. Read More

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http://dx.doi.org/10.1016/j.fct.2018.10.054DOI Listing
October 2018
3 Reads