8,078 results match your criteria Hypoxic-Ischemic Encephalopathy


Removal of a minimal amount of subdural hematoma is effective and sufficient for term neonates with severe symptomatic spontaneous parenchymal hemorrhage.

Childs Nerv Syst 2019 Mar 16. Epub 2019 Mar 16.

Division of Pediatric Neurosurgery, Ibaraki Children's Hospital, 3-3-1 Futabadai, Mito, Ibaraki, 311-4145, Japan.

Introduction: Spontaneous parenchymal hemorrhage of term neonates is usually asymptomatic and does not require surgical intervention. However, there is no consensus on the management of cases with severe life-threatening symptoms, including repeated apnea, respiratory failure with severe cyanosis, severe bradycardia, or uncontrolled seizures.

Cases: Our medical records of term neonates with intracranial hemorrhage who underwent surgical intervention were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00381-019-04114-2DOI Listing

Routine assessment of cerebroplacental ratio at 35-37 weeks' gestation in the prediction of adverse perinatal outcome.

Am J Obstet Gynecol 2019 Mar 13. Epub 2019 Mar 13.

Fetal Medicine Research Institute, King's College Hospital, London, UK. Electronic address:

Background: Third trimester studies in selected high-risk pregnancies have reported that low cerebroplacental ratio (CPR), due to high pulsatility index (PI) in the umbilical artery (UA), and or decreased PI in the fetal middle cerebral artery (MCA), is associated with increased risk of adverse perinatal outcomes.

Objective: To investigate the predictive performance of screening for adverse perinatal outcome by the cerebroplacental ratio (CPR) measured routinely at 35 - 37 weeks' gestation.

Methods: This was a prospective observational study in 47,211 women with singleton pregnancies undergoing routine ultrasound examination at 35 - 37 weeks' gestation, including measurement of UA-PI and MCA-PI. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.002DOI Listing

The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation.

Front Physiol 2019 27;10:141. Epub 2019 Feb 27.

Department of Physiology, The University of Auckland, Auckland, New Zealand.

Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain injury is typically associated with hypoxia-ischemia and/or infection/inflammation. Both hypoxia-ischemia and infection trigger an inflammatory response in the brain. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00141
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http://dx.doi.org/10.3389/fphys.2019.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400979PMC
February 2019
2 Reads

Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review.

Epilepsia Open 2019 Mar 25;4(1):10-29. Epub 2019 Jan 25.

Clinical Neuroscience UCL-Institute of Child Health London UK.

The aim of this study was to evaluate whether specific etiologies of neonatal seizures have distinct ictal electroclinical features. A systematic review of English articles using the PubMed database since 2004 (last update 9/26/16). Search terms included text words and Medical Subject Headings (MeSH) terms related to neonatal seizures. Read More

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http://dx.doi.org/10.1002/epi4.12298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398099PMC
March 2019
2 Reads

Differences in patient characteristics and care practices between two trials of therapeutic hypothermia.

Pediatr Res 2019 Mar 12. Epub 2019 Mar 12.

Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

Background: The Induced Hypothermia (IH) and Optimizing Cooling (OC) trials for hypoxic-ischemic encephalopathy (HIE) had similar inclusion criteria. The rate of death/moderate-severe disability differed for the subgroups treated with therapeutic hypothermia (TH) at 33.5 °C for 72 h (44% vs. Read More

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http://dx.doi.org/10.1038/s41390-019-0371-2DOI Listing

Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory.

Dev Neurosci 2019 Mar 12:1-15. Epub 2019 Mar 12.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland,

Hippocampal injury following neonatal hypoxia-ischemia (HI) leads to memory impairments despite therapeutic hypothermia (TH). In the hippocampus, the expression of calbindin-1 (Calb1), a Ca2+-buffering protein, increases during postnatal development and decreases with aging and neurodegenerative disorders. Since persistent Ca2+ dysregulation after HI may lead to ongoing injury, persistent changes in hippocampal expression of Calb1 may contribute to memory impairments after neonatal HI. Read More

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http://dx.doi.org/10.1159/000497056DOI Listing
March 2019
2 Reads

Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.

J Perinatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Therapeutic hypothermia (TH) has become the standard of care treatment to improve morbidity and mortality in infants with hypoxic-ischemic encephalopathy (HIE). Although TH has clearly proven to be beneficial, recent studies suggest optimization of respiratory management as an approach to prevent further damage and improve neurodevelopmental outcome. The ventilatory management of asphyxiated neonates presents a challenge because both the hypoxic insult and TH have an impact on respiratory functions. Read More

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http://dx.doi.org/10.1038/s41372-019-0349-2DOI Listing

Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

Sci Rep 2019 Mar 11;9(1):4088. Epub 2019 Mar 11.

Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three groups: hypoxic-ischaemic insult with normothermia (NT), insult with hypothermia (TH, 33. Read More

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http://dx.doi.org/10.1038/s41598-019-40674-8DOI Listing

An Inhibitor of the Mitochondrial Permeability Transition Pore Lacks Therapeutic Efficacy Following Neonatal Hypoxia Ischemia in Mice.

Neuroscience 2019 Mar 5. Epub 2019 Mar 5.

Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Neonatal hypoxic ischemic (HI) brain injury causes lifelong neurologic disability. Therapeutic hypothermia (TH) is the only approved therapy that partially mitigates mortality and morbidity. Therapies specifically targeting HI-induced brain cell death are currently lacking. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.030DOI Listing
March 2019
2 Reads

Chest Compressions During Sustained Inflation During Cardiopulmonary Resuscitation in Newborn Infants Translating Evidence From Animal Studies to the Bedside.

JACC Basic Transl Sci 2019 Feb 25;4(1):116-121. Epub 2019 Feb 25.

Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada; and the Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Newborn infants receiving chest compressions in the delivery room have a high incidence of mortality (41%) and short-term neurological morbidity (e.g., 57% hypoxic-ischemic encephalopathy and seizures). Read More

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http://dx.doi.org/10.1016/j.jacbts.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390679PMC
February 2019
1 Read

Intrauterine growth restriction and neonatal hypoxic ischemic brain injury causes sex-specific long-term neurobehavioral abnormalities in rats.

J Neurosci Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

There is a lack of knowledge of factors preventing an adequate response to moderate hypothermia after hypoxic ischemic (HI) brain injury. We hypothesized that growth restriction from reduced intrauterine perfusion would predispose neonatal rats to have a worse outcome with HI brain injury. IUGR was induced by placental insufficiency in dams at 14 days of gestation. Read More

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http://dx.doi.org/10.1002/jnr.24389DOI Listing
March 2019
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In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation.

J Perinatol 2019 Mar 6. Epub 2019 Mar 6.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA.

Objective: To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO).

Study Design: Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN).

Results: Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. Read More

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http://dx.doi.org/10.1038/s41372-019-0345-6DOI Listing
March 2019
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Ophthalmic outcomes following neonatal hypoxic ischaemic encephalopathy; oculomotor, biometric and refractive data in early childhood.

Eye (Lond) 2019 Mar 5. Epub 2019 Mar 5.

Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.

Objectives: To investigate the functional and structural impact of neonatal hypoxic ischaemic encephalopathy (HIE) on childhood visual development.

Methods: In a prospective study, the neurocognitive outcomes of 42 children with a history of neonatal HIE were assessed serially up to 5 years. For the ophthalmic component of the study, visual, refractive, orthoptic and ocular biometry measurements were obtained in 32 children, with axial length measurements estimated using the IOLMaster. Read More

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http://www.nature.com/articles/s41433-019-0390-6
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http://dx.doi.org/10.1038/s41433-019-0390-6DOI Listing
March 2019
1 Read

HIF1α Signaling in the Endogenous Protective Responses after Neonatal Brain Hypoxia-Ischemia.

Dev Neurosci 2019 Mar 5:1-10. Epub 2019 Mar 5.

Department of Pediatrics, University of California San Francisco, San Francisco, California,

Hypoxia-inducible factor 1α (HIF1α) is a key regulator of oxygen homeostasis, and its target genes mediate adaptive, protective, and pathological processes. The role of HIF1α in neuronal survival is controversial and the brain maturation stage is important in determining its function in brain ischemia or hypoxia-ischemia (HI). In this study, we used neuron-specific HIF1α knockout mice at postnatal day 9 (P9), and immature cortical neurons (days 7-8 in vitro) treated with the HIF1α inhibitor 2-methoxyestradiol (2ME2) or stabilizer dimethyloxalylglycine (DMOG), to examine the function of neuronal HIF1α in neonatal HI in vivo (Vannucci model) and in vitro (oxygen glucose deprivation, OGD). Read More

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https://www.karger.com/Article/FullText/495879
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http://dx.doi.org/10.1159/000495879DOI Listing
March 2019
1 Read
2.697 Impact Factor

Study on serum Tau protein level and neurodevelopmental outcome of placental abruption with neonatal hypoxic-ischemic encephalopathy.

J Matern Fetal Neonatal Med 2019 Mar 1:1-221. Epub 2019 Mar 1.

b Department of Neonatal Pathology , Handan Maternal and Child Health Care Hospital of Handan , Handan , P R China.

Objective: The aim of this study was to explore differences in serum Tau protein levels and neurodevelopmental prognoses of placental abruption or umbilical cord around neck with hypoxic-ischemic encephalopathy (HIE).

Methods: Forty neonates with moderate/severe HIE divided into placental abruption with HIE group (placental abruption with hypoxic-ischemic encephalopathy (PA-HIE) group) (n = 18) and umbilical cord around neck with HIE group (umbilical cord around neck with hypoxic-ischemic encephalopathy (UCAN-HIE) group) (n = 22). Healthy term newborns comprised the control group (n = 35). Read More

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http://dx.doi.org/10.1080/14767058.2019.1588878DOI Listing

The Investigation of Rate of Birth Asphyxia and its Relationship with Delivery Mode at Shahid Beheshti Hospital of Isfahan during 2013, 2014, and 2015.

Int J Prev Med 2019 12;10:23. Epub 2019 Feb 12.

Department of Pediatrics, School of Medicine and Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Birth asphyxia is considered as one of the biggest challenges faced by perinatal care experts. According to the WHO, in 2005, one-fourth of infant mortality cases occurred due to birth asphyxia.

Methods: This study is a retrospective study done on the newborn population with gestational ages of 36 weeks or higher during the years 2013, 2014, and 2015 to find the relationship between the number of birth asphyxia cases and the years. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_383_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390421PMC
February 2019

Seizure Susceptibility Correlates with Brain Injury in Male Mice Treated with Hypothermia after Neonatal Hypoxia-Ischemia.

Dev Neurosci 2019 Feb 28:1-10. Epub 2019 Feb 28.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Hypoxic-ischemic encephalopathy is a common neonatal brain injury associated with significant morbidity and mortality despite the administration of therapeutic hypothermia (TH). Neonatal seizures and subsequent chronic epilepsy are frequent in this patient population and current treatments are partially effective. We used a neonatal murine hypoxia-ischemia (HI) model to test whether the severity of hippocampal and cortical injury predicts seizure susceptibility 8 days after HI and whether TH mitigates this susceptibility. Read More

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https://www.karger.com/Article/FullText/496468
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http://dx.doi.org/10.1159/000496468DOI Listing
February 2019
6 Reads

Strain-Related Differences in Mouse Neonatal Hypoxia-Ischemia.

Dev Neurosci 2019 Feb 28:1-7. Epub 2019 Feb 28.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Neonatal hypoxic-ischemic brain injury is commonly studied by means of the Vannucci procedure in mice or rats (unilateral common carotid artery occlusion followed by hypoxia). Previously, we modified the postnatal day 7 (P7) rat procedure for use in mice, and later demonstrated that genetic strain strongly influences the degree of brain injury in the P7 mouse model of hypoxia-ischemia (HI). Recently, the P9 or P10 mouse brain was recognized as the developmental equivalent of a term neonatal human brain, rather than P7. Read More

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http://dx.doi.org/10.1159/000495880DOI Listing
February 2019

Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia⁻Ischaemia.

Brain Sci 2019 Feb 27;9(3). Epub 2019 Feb 27.

The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Melbourne 3168, Australia.

Brain injury in the asphyxic newborn infant may be exacerbated by delayed restoration of cardiac output and oxygen delivery. With increasing severity of asphyxia, cerebral autoregulatory responses are compromised. Further brain injury may occur in association with high arterial pressures and cerebral blood flows following the restoration of cardiac output. Read More

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http://dx.doi.org/10.3390/brainsci9030049DOI Listing
February 2019

Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.

Free Radic Biol Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Neurophyxia BV, 's Hertogenbosch, the Netherlands. Electronic address:

Perinatal asphyxia (PA) is characterized by oxygen deprivation and lack of perfusion in the perinatal period, leading to hypoxic-ischemic encephalopathy and sequelae such as cerebral palsy, mental retardation, cerebral visual impairment, epilepsy and learning disabilities. On cellular level, PA is associated with a decrease in oxygen and glucose leading to ATP depletion, and a compromised mitochondrial function. Upon reoxygenation and reperfusion, the renewed availability of oxygen gives rise to not only restoration of cell function, but also to the activation of multiple detrimental biochemical pathways, leading to secondary energy failure and ultimately cell death. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.025DOI Listing
February 2019
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Cardiac adaptation in asphyxiated infants treated with therapeutic hypothermia.

J Neonatal Perinatal Med 2019 Feb 19. Epub 2019 Feb 19.

Monash Newborn, Monash Children's Hospital, Clayton, Australia.

Background: Hypoxic ischemic encephalopathy (HIE) affects  one to two newborns per 1,000 live births and oftentimes involves multi-organ insult. The objectives were to assess the evolution of cardiac function in infants with HIE treated with therapeutic hypothermia using echocardiography (ECHO).

Methods: Archived data during the period 2010-2016 was assessed. Read More

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http://dx.doi.org/10.3233/NPM-1853DOI Listing
February 2019
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Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs.

BMC Pediatr 2019 Feb 27;19(1):67. Epub 2019 Feb 27.

Children's National Health Systems, Washington, DC, USA.

Background: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with HIE treated with therapeutic hypothermia (TH) across regional NICUs in the US. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1441-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391819PMC
February 2019
5 Reads

Myocardial dysfunction as a predictor of the severity and mortality of hypoxic ischaemic encephalopathy in severe perinatal asphyxia: a case-control study.

Paediatr Int Child Health 2019 Feb 27:1-6. Epub 2019 Feb 27.

b Department of Community Medicine , Geetanjali Medical College and Hospital , Udaipur , India.

Background: In perinatal asphyxia, hypoxia often leads to myocardial ischaemia. Few studies have assessed the degree of myocardial dysfunction in severely asphyxiated term neonates.

Aim: To assess the extent of myocardial damage in newborns with severe perinatal asphyxia. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2019.1
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http://dx.doi.org/10.1080/20469047.2019.1581462DOI Listing
February 2019
7 Reads

Pilose antler polypeptides ameliorate inflammation and oxidative stress and improves gut microbiota in hypoxic-ischemic injured rats.

Nutr Res 2019 Jan 26;64:93-108. Epub 2019 Jan 26.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, China. Electronic address:

Pilose antler polypeptides (PAP) have recently been found to be effective in the treatment of brain damage in hypoxic-ischemic encephalopathy (HIE). However, the impacts of hypoxic-ischemic (HI)-induced injury on oxidative stress and inflammation in peripheral tissues remain unclear. In the present study, we hypothesized that the administration of PAP might exert a protective effect on HI-induced peripheral tissue dysfunction. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.01.005DOI Listing
January 2019
1 Read
2.585 Impact Factor

FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho.

Exp Neurol 2019 Feb 23;317:34-50. Epub 2019 Feb 23.

Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address:

Perinatal asphyxia often results in neonatal cerebral hypoxia-ischemia (HI), which is associated with high mortality and severe long-term neurological deficits in newborns. Currently, there are no effective drugs to mitigate the functional impairments post-HI. Previous studies have shown that fibroblast growth factor 21 (FGF21) has a potential neuroprotective effect against brain injury. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.02.013DOI Listing
February 2019

A New Vision for Therapeutic Hypothermia in the Era of Targeted Temperature Management: A Speculative Synthesis.

Ther Hypothermia Temp Manag 2019 Mar 25;9(1):13-47. Epub 2019 Feb 25.

1 John G. Rangos Research Center, UPMC Children's Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania.

Three decades of animal studies have reproducibly shown that hypothermia is profoundly cerebroprotective during or after a central nervous system (CNS) insult. The success of hypothermia in preclinical acute brain injury has not only fostered continued interest in research on the classic secondary injury mechanisms that are prevented or blunted by hypothermia but has also sparked a surge of new interest in elucidating beneficial signaling molecules that are increased by cooling. Ironically, while research into cold-induced neuroprotection is enjoying newfound interest in chronic neurodegenerative disease, conversely, the scope of the utility of therapeutic hypothermia (TH) across the field of acute brain injury is somewhat controversial and remains to be fully defined. Read More

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http://dx.doi.org/10.1089/ther.2019.0001DOI Listing
March 2019
1 Read

Functional Connectivity in Term Neonates With Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

Pediatr Neurol 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, Vermont.

Background: We investigated whether therapeutic hypothermia and rewarming impact functional connectivity using electroencephalography (EEG) as a measure in neonates with hypoxic-ischemic encephalopathy. We hypothesized that EEG coherence and voltage correlations would be lower and phase lag greater in infants with hypoxic-ischemic encephalopathy than control subjects and that functional connectivity would evolve during therapeutic hypothermia with the greatest improvement occurring during rewarming.

Methods: This study was a retrospective study of 14 term neonates (greater than 37 weeks) with moderate hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia and rewarming. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.006DOI Listing
January 2019
1 Read

Response to antiseizure medications in neonates with acute symptomatic seizures.

Epilepsia 2019 Mar 20;60(3):e20-e24. Epub 2019 Feb 20.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Read More

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http://dx.doi.org/10.1111/epi.14671DOI Listing
March 2019
1 Read

Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.

J Perinat Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopedics, Bhimrao Ambedkar University, Agra, UP, India.

Background Erythropoietin (EPO) appears to confer neuroprotection to the injured brain. Randomized clinical trials (RCTs) have demonstrated its safety in neonates with hypoxic-ischemic encephalopathy (HIE); however, the evidence is unclear. The objective of this study was to examine the role of EPO in perinatal HIE by a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1515/jpm-2018-0360DOI Listing
February 2019
1 Read

Identification of two novel TPK1 gene mutations in a Chinese patient with thiamine pyrophosphokinase deficiency undergoing whole exome sequencing.

J Pediatr Endocrinol Metab 2019 Mar;32(3):295-300

Associate Senior Physician and Associate Professor of Department of Neurology and Development, The Seventh Medical Center of PLA General Hospital, Beijing, China.

Background The mutations of thiamine pyrophosphokinase-1 (TPK1) gene have been frequently studied in some patients with thiamine metabolism dysfunction syndrome-5 (THMD5), while TPK1 mutations in Chinese patients have been investigated by only homozygous. A search of the literature on the mutations in the Chinese population currently published revealed that no reports of compound heterozygous mutations were reported. Here, we report a Chinese patient with compound heterozygous TPK1 mutations who underwent magnetic resonance imaging (MRI), whole exome sequencing (WES), molecular diagnosis, bioinformatics analysis, and three-dimensional (3D) protein structure analysis. Read More

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http://dx.doi.org/10.1515/jpem-2018-0363DOI Listing

Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.

J Clin Monit Comput 2019 Feb 20. Epub 2019 Feb 20.

Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.

In a recent study, we proposed a novel method to evaluate hypoxic ischemic encephalopathy (HIE) by assessing propofol-induced changes in the 19-channel electroencephalogram (EEG). The study suggested that patients with HIE are unable to generate EEG slow waves during propofol anesthesia 48 h after cardiac arrest (CA). Since a low number of electrodes would make the method clinically more practical, we now investigated whether our results received with a full EEG cap could be reproduced using only forehead electrodes. Read More

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http://dx.doi.org/10.1007/s10877-019-00282-3DOI Listing
February 2019

Placental findings among newborns with hypoxic ischemic encephalopathy.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA.

Objective: To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy.

Study Design: Retrospective case-control study of newborns with HIE (2006-2014) and controls matched for birth year, gestational age, weight, and gender. One pathologist reviewed archived placental sections using pre-specified criteria. Read More

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http://dx.doi.org/10.1038/s41372-019-0334-9DOI Listing
February 2019
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Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia-Ischemia: Potential Mechanism of Action.

Mol Neurobiol 2019 Feb 14. Epub 2019 Feb 14.

Neurorepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 A. Pawinskiego Street, 02-106, Warsaw, Poland.

Neonatal hypoxic-ischemic (HI) brain injury likely represents the major cause of long-term neurodevelopmental disabilities in surviving babies. Despite significant investigations, there is not yet any known reliable treatment to reduce brain damage in suffering infants. Our recent studies in an animal model of HI revealed the therapeutic potential of a histone deacetylase inhibitor (HDACi). Read More

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http://dx.doi.org/10.1007/s12035-019-1518-1DOI Listing
February 2019
1 Read

Bestrophin-3 Expression in a Subpopulation of Astrocytes in the Neonatal Brain After Hypoxic-Ischemic Injury.

Front Physiol 2019 29;10:23. Epub 2019 Jan 29.

Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Bestrophin-3, a potential candidate for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. We studied the expression and alternative splicing of bestrophin-3 in neonatal mouse brain and after hypoxic-ischemic (HI) injury and in human neonatal brain samples. HI brain injury was induced in 9-day old mice by unilateral permanent common carotid artery occlusion in combination with exposure to 10% oxygen for 50 min. Read More

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http://dx.doi.org/10.3389/fphys.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362097PMC
January 2019
1 Read

Monitoring the effectiveness of hypothermia in perinatal asphyxia infants by urinary S100B levels.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Alessandria, Italy.

Background Perinatal asphyxia is a major cause of mortality and morbidity in neonates: The aim of the present study was to investigate, by means of longitudinal assessment of urinary S100B, the effectiveness of hypothermia, in infants complicated by perinatal asphyxia and hypoxic-ischemic encephalopathy. Methods We performed a retrospective case-control study in 108 asphyxiated infants, admitted to nine tertiary departments for neonatal intensive care from January 2004 to July 2017, of whom 54 underwent hypothermia treatment and 54 did not. The concentrations of S100B protein in urine were measured using an immunoluminometric assay at first urination and 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120 h after birth. Read More

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http://dx.doi.org/10.1515/cclm-2018-1094DOI Listing
February 2019
2 Reads

Are increased fetal movements always reassuring?

J Matern Fetal Neonatal Med 2019 Feb 22:1-6. Epub 2019 Feb 22.

a Department of Obstetrics and Gynecology , University of Toronto , Toronto , Canada.

Many studies have reported on the association of reduced fetal movements and stillbirth, but little is known about excessive fetal movements and adverse pregnancy outcome. First described in 1977, sudden excessive fetal movement was noted to reflect acute fetal distress and subsequent fetal demise. Subsequently, little was reported regarding this phenomenon until 2012. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582027DOI Listing
February 2019
2 Reads

Anthropometric measures as biomarkers of neurodevelopmental outcomes of newborns with moderate to severe hypoxic ischemic encephalopathy.

J Neonatal Perinatal Med 2019 Feb 4. Epub 2019 Feb 4.

Division of Neonatal-Perinatal Medicine, Wayne State University, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, MI, USA.

Background: Perinatal asphyxia is a prominent cause of neonatal mortality in the developing world. Growth in head circumference is associated with improved neurodevelopment. Previous studies found a positive correlation between additional dietary supplementation and growth in head circumference among newborns with perinatal brain injury. Read More

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http://dx.doi.org/10.3233/NPM-17151DOI Listing
February 2019
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Increased expression of cannabinoid CB and serotonin 5-HT heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage.

Neuropharmacology 2019 Feb 7. Epub 2019 Feb 7.

Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED). Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Physiology. Facultat de Farmàcia. Universitat de Barcelona, Barcelona, Spain. Electronic address:

Preclinical work shows cannabidiol as a promising drug to manage neonatal hypoxic-ischemic brain damage (NHIBD). The molecular mechanism is not well defined but the beneficial effects of this phytocannabinoid are blocked by antagonists of both cannabinoid CB (CBR) and serotonin 5-HT (5-HT1AR) receptors that, in addition, may form heteromers in a heterologous expression system. Using bioluminescence energy transfer, we have shown a direct interaction of the two receptors that leads to a particular signaling in a heterologous system. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.004DOI Listing
February 2019

Predictive factors and prognostic value for status epilepticus in newborns.

Eur J Paediatr Neurol 2019 Mar 29;23(2):270-279. Epub 2019 Jan 29.

Epileptology, Sleep Disorders and Functional Pediatric Neurology, Member of ERN-EpiCARE; HFME, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron, France.

Objectives: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE.

Methods: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.006DOI Listing
March 2019
2 Reads

Melatonin pharmacokinetics and dose extrapolation after enteral infusion in neonates subjected to hypothermia.

J Pineal Res 2019 Feb 8:e12565. Epub 2019 Feb 8.

Department of Molecular and Developmental Medicine, University of Siena.

Introduction: Neonates with hypoxic-ischemic encephalopathy (HIE) undergoing hypothermia may benefit from adjunctive therapy with melatonin. However, melatonin safety, pharmacokinetics (PK), and dosage in this sensitive population is still unknown.

Methods And Results: This study assessed the PK and safety of melatonin enteral administration to neonates with HIE undergoing hypothermia. Read More

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http://dx.doi.org/10.1111/jpi.12565DOI Listing
February 2019
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9.600 Impact Factor

miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.

Front Neurosci 2019 23;13:16. Epub 2019 Jan 23.

Institute of Neuroscience, Kunming Medical University, Kunming, China.

Neuronal apoptosis is a major pathological hallmark of the neonatal hypoxic-ischemic brain damage (HIBD); however, the role of miR-7a-2-3p in the regulation of HIBD remains unknown. The purpose of this study was to explore the possible roles of miR-7a-2-3p in brain injury using a hypoxia-ischemia model in rats and oxygen-glucose deprivation (OGD) model . Firstly, we established the hypoxia-ischemia (HI) model and verified the model using Zea Longa scores and MRI in rats. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00016
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http://dx.doi.org/10.3389/fnins.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351497PMC
January 2019
5 Reads

Monitoring Gas Exchange During Hypothermia for Hypoxic-Ischemic Encephalopathy.

Pediatr Crit Care Med 2019 Feb;20(2):166-171

Department of Pediatrics, University of California at Davis, Sacramento, CA.

Objectives: Therapeutic hypothermia is standard of care in management of moderate/severe hypoxic-ischemic encephalopathy. Persistent pulmonary hypertension of the newborn is associated with hypoxic-ischemic encephalopathy and is exacerbated by hypoxemia and hypercarbia. Gas exchange is assessed by arterial blood gas analysis (with/without correction for body temperature), pulse oximetry, and end-tidal CO2. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366447PMC
February 2019
3 Reads

The neurointensive nursery: concept, development, and insights gained.

Curr Opin Pediatr 2019 Apr;31(2):202-209

Department Pediatrics, UCSF Benioff Children's Hospital.

Purpose Of Review: With the advent of therapeutic hypothermia for treatment of hypoxic ischemic encephalopathy, and improvements in neuroimaging and bedside neuromonitoring, a new era of neonatal brain-focused care has emerged in recent years. We describe the development of the first neurointensive care nursery (NICN) as a model for comanagement of neonates with identified neurologic risk factors by a multidisciplinary team constituted of neurologists, neonatologists, specialized nurses, and others with the goal of optimizing management, preventing secondary injury and maximizing long-term outcomes.

Recent Findings: Optimizing brain metabolic environment and perfusion and preventing secondary brain injury are key to neurocritical care. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000733DOI Listing
April 2019
2 Reads

Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy.

Cell Death Dis 2019 Feb 4;10(2):97. Epub 2019 Feb 4.

Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.

Hypoxic-ischemic encephalopathy (HIE) is a devastating neurological event that contributes to the prolonged neurodevelopmental consequences in infants. Therapeutic strategies focused on attenuating neuronal apoptosis in the penumbra appears to be promising. Given the increasingly recognized neuroprotective roles of adipokines in HIE, we investigated the potential anti-apoptotic roles of a novel member of adipokines, Chemerin, in an experimental model of HIE. Read More

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http://dx.doi.org/10.1038/s41419-019-1374-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362229PMC
February 2019
1 Read
5.014 Impact Factor

The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy.

Neuropharmacology 2019 May 1;149:55-65. Epub 2019 Feb 1.

Center of Neuroscience, Surgery and Trauma, Blizard Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, UK. Electronic address:

Neonates can develop hypoxic-ischaemic encephalopathy (HIE) due to lack of blood supply or oxygen, resulting in a major cause of death and disability among term newborns. However, current definitive treatment of therapeutic hypothermia, will only benefit one out of nine babies. Furthermore, the mechanisms of HIE and therapeutic hypothermia are not fully understood. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.11.041DOI Listing
May 2019
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Spinal Hyper-Excitability and Altered Muscle Structure Contribute to Muscle Hypertonia in Newborns After Antenatal Hypoxia-Ischemia in a Rabbit Cerebral Palsy Model.

Front Neurol 2018 17;9:1183. Epub 2019 Jan 17.

Department of Pediatrics, NorthShore University HealthSystem Research Institute, Evanston, IL, United States.

Rabbit kits after global antenatal hypoxic-ischemic injury exhibit motor deficits similar to humans with cerebral palsy. We tested several mechanisms previously implicated in spinal hyper-excitability after perinatal brain injury that may explain muscle hypertonia in newborns. Stiffness of hind limb muscles during passive stretch, electromyogram, and spinal excitability by Hoffman reflex, were assessed in rabbit kits with muscle hypertonia after global hypoxic-ischemic brain injury and naïve controls. Read More

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http://dx.doi.org/10.3389/fneur.2018.01183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344443PMC
January 2019
13 Reads

Roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons.

Pathol Res Pract 2019 Jan 18. Epub 2019 Jan 18.

Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, Jiangsu Province, China. Electronic address:

Background: To explore the roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons.

Methods: The sera of neonates with hypoxic-ischemic encephalopathy (HIE) within 24 h after birth and full-term healthy newborns (n = 40) were collected. The BNIP3 levels were detected by ELISA. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.022DOI Listing
January 2019

Anal sphincter injury associated with shoulder dystocia.

J Matern Fetal Neonatal Med 2019 Jan 29:1-5. Epub 2019 Jan 29.

a Department of Obstetrics and Gynaecology , Our Lady of Lourdes Hospital , Drogheda , Ireland.

Objective: Shoulder dystocia is an obstetric emergency, occurring in 0.2-3% of vaginal deliveries. Research has mainly focused on the neonatal morbidity arising from shoulder dystocia, such as brachial plexus injury and hypoxic-ischemic encephalopathy. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1569617DOI Listing
January 2019
4 Reads

Prognostic Value of Electroencephalography in Hypothermia-Treated Neonates With Hypoxic-Ischemic Encephalopathy: A Meta-Analysis.

Pediatr Neurol 2018 Dec 28. Epub 2018 Dec 28.

Department of Pediatrics, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Electroencephalography (EEG) background activity is associated with neurological outcome in neonates with hypoxic-ischemic encephalopathy. There is uncertainty about the prognostic value of EEG background activity after hypothermia was introduced.

Methods: Searches were made on Pubmed, Embase, and the Cochrane Library, from inception to March 1, 2018. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.013DOI Listing
December 2018
3 Reads

A Functional Domain Based Approach in Neurocognitive Rehabilitation with Transcranial Direct Current Stimulation: A Case Report.

Clin Psychopharmacol Neurosci 2019 Feb;17(1):125-129

Translational Psychiatry Laboratory, Neurobiology Research Centre & Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

Transcranial direct current stimulation (tDCS) is a novel brain stimulation technique which has kindled hope in alleviating motor, language as well as cognitive deficits in neuronal injury. Current case report describes application of tDCS in two phases using two different protocols in a patient with hypoxic injury. In the first phase anodal stimulation of dorsolateral prefrontal cortex improved the language fluency. Read More

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http://dx.doi.org/10.9758/cpn.2019.17.1.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361037PMC
February 2019
3 Reads