2,702 results match your criteria Hypoventilation Syndromes


Non-Obstructive Middle Lobe Syndrome: An Unusual Cause of Recurrent Pneumonia in an Elderly Woman.

Eur J Case Rep Intern Med 2018 31;5(1):000737. Epub 2018 Jan 31.

Serviço de Medicina Interna B, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

An 84-year-old woman had five episodes of pneumonia in 4 months. Despite extensive comorbidities and advanced age, her health status was good and the recurrence seemed unjustified. Exhaustive background investigation revealed 14 episodes of right-sided pneumonias during the 3 previous years and an inconclusive investigation with CT of the thorax and bronchofibroscopy, despite some fibrotic and atelectasic alterations in the right middle lobe. Read More

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http://dx.doi.org/10.12890/2017_000737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346942PMC
January 2018
1 Read

Causes of secondary hypertension from a single center in Northern Greece; a retrospective clinical study.

Folia Med Cracov 2018 ;58(4):35-45

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Hypertension constitutes one of the most common diseases leading patients to the Outpatient Departments. Idiopathic hypertension is the prevailing type, but on the other hand, the possible presence of clinical entities responsible for the development of secondary hypertension should never be underestimated. We retrospectively studied 447 subjects aged between 20 and 84 years old and diagnosed with hypertension, who were thoroughly evaluated for secondary hypertension. Read More

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January 2018
1 Read

Sleep Complaints, Sleep and Breathing Disorders in Myotonic Dystrophy Type 2.

Curr Neurol Neurosci Rep 2019 Feb 9;19(2). Epub 2019 Feb 9.

Department of Clinical Medicine and Surgery, Section of Respiratory Diseases, University of Naples Federico II, Naples, Italy.

Purpose Of Review: To update the current knowledge concerning sleep complaints and breathing disorders in myotonic dystrophy type 2 (DM2) and to better understand if sleep and breathing symptoms may add a further clinical definition of DM2.

Recent Findings: Although DM2 has been poorly evaluated, the most relevant sleep disorders are sleep-disordered breathing (SDB) (37.5-66. Read More

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http://link.springer.com/10.1007/s11910-019-0924-0
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http://dx.doi.org/10.1007/s11910-019-0924-0DOI Listing
February 2019
2 Reads

Obesity hypoventilation syndrome: a current review.

J Bras Pneumol 2018 Nov-Dec;44(6):510-518

. Laboratório do Sono, Disciplina de Pneumologia, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

Obesity hypoventilation syndrome (OHS) is defined as the presence of obesity (body mass index ≥ 30 kg/m²) and daytime arterial hypercapnia (PaCO2 ≥ 45 mmHg) in the absence of other causes of hypoventilation. OHS is often overlooked and confused with other conditions associated with hypoventilation, particularly COPD. The recognition of OHS is important because of its high prevalence and the fact that, if left untreated, it is associated with high morbidity and mortality. Read More

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http://dx.doi.org/10.1590/S1806-37562017000000332DOI Listing
September 2017
1 Read

Comorbidities associated with obstructive sleep apnea: a retrospective Egyptian study on 244 patients.

Sleep Breath 2019 Jan 26. Epub 2019 Jan 26.

Department of Chest Diseases, Faculty of Medicine, University of Alexandria, 26 Mostafa kamel officer buildings, Alexandria, Egypt.

Purpose: The aim of the present study was to assess prevalence of associated comorbidities in a group of patients diagnosed with obstructive sleep apnea syndrome (OSAS).

Methods: This retrospective study enrolled 244 consecutive patients diagnosed by polysomnogram with OSAS between October 2010 and January 2015 after being referred to our Sleep-Related Breathing Disorders Unit, Chest Diseases Department, in the Alexandria Main University Hospital.

Results: Of 244 patients, 47% were men, mean age was 56. Read More

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http://dx.doi.org/10.1007/s11325-019-01783-wDOI Listing
January 2019
3 Reads

Congenital central hypoventilation syndrome: Severe disease caused by co-occurrence of two PHOX2B variants inherited separately from asymptomatic family members.

Am J Med Genet A 2019 Mar 23;179(3):503-506. Epub 2019 Jan 23.

Division of Pediatric Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, Illinois.

Congenital Central Hypoventilation Syndrome (CCHS) is a rare disease characterized by autonomic nervous system dysregulation. Central hypoventilation is the most prominent and clinically important presentation. CCHS is caused by mutations in paired-like homeobox 2b (PHOX2B) and is inherited in an autosomal dominant pattern. Read More

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http://dx.doi.org/10.1002/ajmg.a.61047DOI Listing
March 2019
2 Reads

Caloric intake and the fat-to-carbohydrate ratio in hypercapnic acute respiratory failure: Post-hoc analysis of the PermiT trial.

Clin Nutr ESPEN 2019 Feb 13;29:175-182. Epub 2018 Nov 13.

Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Electronic address:

Background: The effect of moderate caloric enteral intake in critically ill patients with hypercapnic acute respiratory failure (HCARF) is unclear. We studied the impact of permissive underfeeding (PUF) compared with standard feeding (SF) on various HCARF outcomes.

Materials And Methods: The PermiT trial randomized 894 patients to either PUF (40-60% caloric requirement) or SF (70-100% requirement) with similar protein intake and found no difference in mortality, mechanical ventilation (MV) duration and ventilator-free days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054577183055
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http://dx.doi.org/10.1016/j.clnesp.2018.10.012DOI Listing
February 2019
5 Reads

Transient Acquired Hypoventilation Syndrome Secondary to Uncal Herniation Is Successfully Treated with Bilevel Noninvasive Positive Pressure Ventilation.

Case Rep Crit Care 2018 17;2018:7013916. Epub 2018 Dec 17.

Penn Medicine Princeton Health, Plainsboro, NJ, USA.

Background: To describe an unusual presentation of acquired hypoventilation syndrome treated successfully with noninvasive positive pressure ventilation.

Case Presentation: We report a case report of a 48-year-old male who presented to the emergency room for recurrent syncope. He was found to have a ventricular colloid cyst causing uncal herniation. Read More

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http://dx.doi.org/10.1155/2018/7013916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311816PMC
December 2018
2 Reads

Obesity cardiomyopathy: the role of obstructive sleep apnea and obesity hypoventilation syndrome.

Ir J Med Sci 2019 Jan 15. Epub 2019 Jan 15.

Respiratory Division, University Hospital Limerick, Limerick, Ireland.

The negative long-term health consequences of obesity are well known to both the medical profession and general public. Despite this, the number of obese and overweight individuals worldwide continues to steadily rise. Although obesity has long been associated with an increased risk for cardiovascular disease and mortality, the classification of a cardiomyopathy of obesity is a more recent development. Read More

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http://link.springer.com/10.1007/s11845-018-01959-5
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http://dx.doi.org/10.1007/s11845-018-01959-5DOI Listing
January 2019
13 Reads

Non-invasive ventilation in acute respiratory failure of patients with obesity hypoventilation syndrome.

Minerva Med 2018 Dec;109(6 Suppl 1):1-5

Unit of Respiratory Diseases and Allergies, Department of Internal Medicine (DiMI), San Martino University Hospital, Genoa, Italy.

Introduction: Non-invasive ventilation (NIV) has been used successfully for the management of acute respiratory failure (ARF) more often in the last two decades compared to prior decades. There are particular groups of patients that are more likely to benefit from NIV. One of these groups is patients with obesity hypoventilation syndrome (OHS). Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05921-9DOI Listing
December 2018
1 Read

Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function.

Thorax 2019 Mar 12;74(3):219-228. Epub 2019 Jan 12.

Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: In acute respiratory distress syndrome (ARDS), pulmonary perfusion failure increases physiologic dead space ventilation (V/V), leading to a decline of the alveolar CO concentration [CO]. Although it has been shown that alveolar hypocapnia contributes to formation of atelectasis and surfactant depletion, a typical complication in ARDS, the underlying mechanism has not been elucidated so far.

Methods: In isolated perfused rat lungs, cytosolic or mitochondrial Ca concentrations ([Ca] or [Ca], respectively) of alveolar epithelial cells (AECs), surfactant secretion and the projected area of alveoli were quantified by real-time fluorescence or bright-field imaging (n=3-7 per group). Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211864DOI Listing
March 2019
2 Reads

Health-related quality of life as predictor for mortality in patients treated with long-term mechanical ventilation.

BMC Pulm Med 2019 Jan 11;19(1):13. Epub 2019 Jan 11.

Department of Global Public Health and Primary Care, University in Bergen, Kalfarveien 31, 5018, Bergen, Norway.

Background: The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present study was to examine whether SRI sum scores and related subscales are associated with mortality in LTMV patients.

Methods: The study included 112 LTMV patients (non-invasive and invasive) from the Norwegian LTMV registry in Western Norway from 2008 with follow-up in August 2014. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-018-0768-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330471PMC
January 2019
6 Reads

Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Obesity hypoventilation syndrome (OHS) is a serious disorder characterized by daytime hypercapnia, disordered breathing, and a reduction in chemosensitivity. Vertical sleeve gastrectomy (VSG), a bariatric surgical procedure resulting in weight loss and weight-independent improvements in glucose metabolism, has been observed to substantially improve sleep-disordered breathing. However, it is unclear if the ventilatory effects of VSG are secondary to weight loss or the marked change in metabolic physiology. Read More

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http://dx.doi.org/10.1172/jci.insight.124469DOI Listing
January 2019
1 Read

Activation of Phox2b-expressing neurons in the nucleus tractus solitarii drives breathing in mice.

J Neurosci 2019 Jan 9. Epub 2019 Jan 9.

Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal phenotype and circuit mechanism involved in such a physiological function remain incompletely understood. This study focused on the respiratory role of paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons and sought to determine whether selective stimulation of this set of neurons activates breathing in male mice. A Cre-dependent vector encoding a Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into the NTS of Phox2b-Cre transgenic mice. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2048-18.2018DOI Listing
January 2019
2 Reads
6.344 Impact Factor

Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review.

Biomed Res Int 2018 21;2018:1250721. Epub 2018 Nov 21.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background And Aim: ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically review its clinical manifestation and to identify genetic causes. Read More

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https://www.hindawi.com/journals/bmri/2018/1250721/
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http://dx.doi.org/10.1155/2018/1250721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280256PMC
November 2018
2 Reads

Volume-targeted pressure support and automatic EPAP for chronic hypoventilation syndromes: An advance in-home ventilation or just more noise?

Authors:
Nigel McArdle

Respirology 2018 Dec 21. Epub 2018 Dec 21.

Department of Pulmonary Physiology and Sleep Medicine, Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia.

Early in the history of non-invasive ventilation (NIV) for disorders of hypoventilation, treatment was provided by volume-limited (VL) devices. Currently, NIV is commonly provided by pressure-limited (PL) devices because of greater portability, lower cost and studies showing increased patient comfort. There are now volume-targeted (VT) devices, which aim to combine the advantages of more stable ventilation associated with VL and greater comfort of PL mode. Read More

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http://doi.wiley.com/10.1111/resp.13458
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http://dx.doi.org/10.1111/resp.13458DOI Listing
December 2018
5 Reads

The genetics of congenital central hypoventilation syndrome: clinical implications.

Appl Clin Genet 2018 15;11:135-144. Epub 2018 Nov 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA,

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system (ANS) and respiratory control. This disorder, formerly referred to as Ondine's curse, is due to a mutation in the gene that affects the development of the neural crest cells. CCHS has an autosomal dominant pattern of inheritance. Read More

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http://dx.doi.org/10.2147/TACG.S140629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241683PMC
November 2018
4 Reads

Efficacy of bilevel ventilatory support in the treatment of stable patients with obesity hypoventilation syndrome: systematic review and meta-analysis.

Sleep Med 2019 Jan 10;53:153-164. Epub 2018 Oct 10.

Postgraduate Program in Pneumological Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400/2 Andar, Porto Alegre, RS, CEP 90035-003, Brazil; Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, CEP 90035-903, Brazil. Electronic address:

Objective: To systematically review the effects of bilevel ventilatory support (BVS) in patients with Obesity Hypoventilation Syndrome (OHS).

Methods: A search of databases (MEDLINE accessed by PubMed, Cochrane CENTRAL, EMBASE and LILACS) was conducted from inception to June 2018. Randomized trials comparing BVS to other therapeutic modalities such as lifestyle counseling, continuous positive airway pressure (PAP) or BVS with average volume assured pressure support for the treatment of patients with OHS were included. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.016DOI Listing
January 2019
2 Reads

Adult With Mutation and Late-Onset Congenital Central Hypoventilation Syndrome.

J Clin Sleep Med 2018 Dec 15;14(12):2079-2081. Epub 2018 Dec 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, California.

Abstract: 20/27 polyalanine repeat mutation (PARM) in patients with congenital central hypoventilation syndrome (CCHS) is generally associated with full-time ventilator dependence, Hirschsprung disease, and increased risk for cardiac asystole. We follow a 14-year-old boy with CCHS 20/27 PARM who is full-time ventilator dependent via tracheostomy and has Hirschsprung disease. His mother, age 52 years, has a history of prolonged recovery from anesthesia and an elevated serum bicarbonate level of 45 mEq/L discovered on routine blood chemistry. Read More

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http://dx.doi.org/10.5664/jcsm.7542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287728PMC
December 2018
5 Reads

Left ventricular diastolic dysfunction in patients with obesity hypoventilation syndrome.

J Thorac Dis 2018 Oct;10(10):5747-5754

University Sleep Disorders Centre, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Obesity hypoventilation syndrome (OHS) can be complicated by several cardiovascular conditions. We assessed the prevalence and factors associated with left ventricular diastolic dysfunction (LVDD) in patients with OHS.

Methods: In this prospective observational study, all consecutive OHS patients referred to the sleep disorders clinic between January 2002 to December 2016 were included (n=113). Read More

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http://dx.doi.org/10.21037/jtd.2018.09.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236195PMC
October 2018
1 Read

Clinical approach to cardiac pauses in congenital central hypoventilation syndrome.

Pediatr Pulmonol 2019 Feb 20;54(2):E4-E6. Epub 2018 Nov 20.

Division and Chair of Cardiology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.

Congenital central hypoventilation syndrome (CCHS) patients may have heart rhythm disorders related to autonomic nervous system dysfunction such as, sinus bradycardia and transient asystole with potentially dramatic syncopal events. The diagnosis of these cardiac alterations may be challenging with conventional periodical Holter monitoring. The case shows how continuous heart rhythm monitoring provided by the implantable cardiac monitor (ICM) may play a crucial role for their early diagnosis and the choice of the appropriate therapeutic intervention. Read More

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http://dx.doi.org/10.1002/ppul.24189DOI Listing
February 2019
15 Reads

Mecp2 Disruption in Rats Causes Reshaping in Firing Activity and Patterns of Brainstem Respiratory Neurons.

Neuroscience 2019 01 17;397:107-115. Epub 2018 Nov 17.

Department of Biology, Georgia State University, 50 Decatur Street, Atlanta, GA 30302, United States. Electronic address:

People with Rett Syndrome (RTT), a neurodevelopmental disorder caused by mutations in the MECP2 gene, have breathing abnormalities manifested as periodical hypoventilation with compensatory hyperventilation, which are attributable to a high incidence of sudden death. Similar breathing abnormalities have been found in animal models with Mecp2 disruptions. Although RTT-type hypoventilation is believed to be due to depressed central inspiratory activity, whether this is true remains unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183073
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http://dx.doi.org/10.1016/j.neuroscience.2018.11.011DOI Listing
January 2019
5 Reads

A retrospective study on sleep-disordered breathing in Morquio-A syndrome.

Am J Med Genet A 2018 Dec 18;176(12):2595-2603. Epub 2018 Nov 18.

Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.

Respiratory problems are common in Morquio-A syndrome (MPS IVA) but objective data on sleep-disordered breathing are scarce. The aim of our study was to review polygraphic (PG) findings and the need for noninvasive continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in children with MPS IVA. A retrospective review of the clinical charts and PG of 16 consecutive children (7 boys, mean age 10. Read More

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http://doi.wiley.com/10.1002/ajmg.a.40642
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http://dx.doi.org/10.1002/ajmg.a.40642DOI Listing
December 2018
13 Reads

Dysregulated glucose homeostasis in congenital central hypoventilation syndrome.

J Pediatr Endocrinol Metab 2018 Dec;31(12):1325-1333

Department of Endocrinology and Diabetes, Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia.

Background Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic control. A hypoglycaemic seizure in a 4-year-old girl with CCHS led to a more detailed examination of glycaemic control in a cohort of children with CCHS. Methods We conducted an observational cohort study of glucose homeostasis in seven children (3 months to 12 years) with genetically confirmed CCHS using a combination of continuous glucose monitoring (CGM), fasting studies and oral glucose tolerance test (OGTT). Read More

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http://www.degruyter.com/view/j/jpem.ahead-of-print/jpem-201
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http://dx.doi.org/10.1515/jpem-2018-0086DOI Listing
December 2018
8 Reads

Obstructive sleep apnoea and hypoventilation in an adult with congenital myasthenic syndrome.

BMJ Case Rep 2018 Nov 14;2018. Epub 2018 Nov 14.

Johns Hopkins Hospital and Health System, Baltimore, Maryland, USA.

In this case report, we describe an adult male with congenital myasthenic syndrome due to mutations in muscle-specific receptor tyrosine kinase (, c.79+2 T>G; IVS1 +2 T>G, c.2368 G>A, Val790Met) presenting with sleep apnoea and hypercapnic respiratory failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-226534DOI Listing
November 2018
7 Reads

Comparison between auto-trilevel and bilevel positive airway pressure ventilation for treatment of patients with concurrent obesity hypoventilation syndrome and obstructive sleep apnea syndrome.

Sleep Breath 2018 Nov 13. Epub 2018 Nov 13.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.

Purpose: Our study aims to compare the difference in clinical efficacy between auto-trilevel positive airway pressure (auto-trilevel PAP) ventilator and conventional fixed bilevel positive airway pressure (BiPAP) ventilator for obesity hypoventilation syndrome (OHS) patients with coexisting moderate or severe obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: Twenty-three OHS patients with moderate or severe OSAHS enrolled between January 2015 and September 2017 underwent ventilation by three different modes of positive airway pressure (PAP) for 8 h per night. A single variable mode was applied at the first night followed by two nights when no PAP therapy was carried out as a washout period between each mode. Read More

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http://link.springer.com/10.1007/s11325-018-1750-3
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http://dx.doi.org/10.1007/s11325-018-1750-3DOI Listing
November 2018
10 Reads

Spinal anesthesia and postoperative epidural analgesia in a patient with congenital central hypoventilation sydrome.

Korean J Anesthesiol 2018 Nov 14. Epub 2018 Nov 14.

Department of Anesthesiology and Pain Medicine, Korean Institute of Radiological & Medical Science, Seoul, KOREA.

Congenital central hypoventilation syndrome (CCHS), also known as Ondine's Curse, is a rare disorder characterized by alveolar hypoventilation and autonomic dysregulation. Patients with CCHS have adequate ventilation while awake but exhibit hypoventilation while asleep. More severely affected patients exhibit hypoventilation both when awake and when asleep. Read More

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http://dx.doi.org/10.4097/kja.d.18.00118DOI Listing
November 2018
1 Read

An unusual case of hypercapnic respiratory failure.

Respir Med Case Rep 2018 23;25:327-329. Epub 2018 Oct 23.

University of Florida College of Medicine, Pulmonary & Critical Care, USA.

Asphyxiating thoracic dystrophy (ATD also known as Jeune syndrome) is a very rare disorder with an incidence in the United States of 1 case per 100,000-130,000 live births. Chronic alveolar hypoventilation leading to concurrent hypoxia is the main cause of morbidity and mortality in these patients due to its complications. A 22-year-old male with past medical history of ATD and severe kyphoscoliosis presented with progressively worsening shortness of breath for several days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183020
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http://dx.doi.org/10.1016/j.rmcr.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214860PMC
October 2018
12 Reads

Association Between 25-Hydroxyvitamin D and Bone Mineral Density in People With Obstructive Sleep Apnea Syndrome.

J Clin Densitom 2019 Jan - Mar;22(1):39-46. Epub 2018 Oct 6.

Gaziosmanpaşa University Faculty of Medicine, Department of Pulmonary Diseases, Tokat, Turkey.

The aim of this study was to evaluate the association between bone mineral density (BMD) and 25-hydroxyvitamin D [25(OH) D] levels in patients with obstructive sleep apnea syndrome (OSAS). This study was designed as a cross-sectional and observational study. Patients who underwent polysomnography evaluation were classified as normal, mild, moderate, severe, or position-dependent OSAS, and OSAS + obesity hypoventilation syndrome (OHS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950183017
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http://dx.doi.org/10.1016/j.jocd.2018.10.001DOI Listing
October 2018
7 Reads

[A case of Creutzfeldt-Jakob disease with E200K mutation presenting with hearing loss and central hypoventilation].

Rinsho Shinkeigaku 2018 Nov 27;58(11):673-676. Epub 2018 Oct 27.

Department of Neurology, The Jikei University Kashiwa Hospital.

We report the case of a 43-year-old female patient who presented with symptoms of abnormal behavior, hearing loss, ataxic gait, central hyperventilation which had appeared over the course of one month. Brain MRI showed no abnormal findings in DWI and EEG did not indicate periodic synchronous discharge (PSD). Over the course of the same month, she also presented with central apnea that intermittently showed spontaneous improvement and reappearance. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001197DOI Listing
November 2018
1 Read

Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation.

PLoS One 2018 25;13(10):e0205669. Epub 2018 Oct 25.

Service de Pneumologie, Département des spécialités de médecine, Geneva University Hospitals, Geneva, Switzerland.

Rationale: Acute hypercapnic respiratory failure (AHRF) treated with non-invasive ventilation in the ICU is frequently caused by chronic obstructive pulmonary disease (COPD) exacerbations and obesity-hypoventilation syndrome, the latter being most often associated with obstructive sleep apnea. Overlap syndrome (a combination of COPD and obstructive sleep apnea) may represent a major burden in this population, and specific diagnostic pathways are needed to improve its detection early after ICU discharge.

Objectives: To evaluate whether pulmonary function tests can identify a high probability of obstructive sleep apnea in AHRF survivors and outperform common screening questionnaires to identify the disorder. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205669PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201889PMC
October 2018
3 Reads

Intranasal Leptin Relieves Sleep Disordered Breathing in Mice with Diet Induced Obesity.

Am J Respir Crit Care Med 2018 Oct 12. Epub 2018 Oct 12.

Johns Hopkins University, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States.

Rationale: Leptin treats upper airway obstruction and alveolar hypoventilation in leptin deficient ob/ob mice. However, obese humans and mice with diet-induced obesity are resistant to leptin due to poor permeability of the blood-brain barrier. We propose that intranasal leptin will bypass leptin resistance and treat sleep disordered breathing in obesity. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201805-0879OC
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http://dx.doi.org/10.1164/rccm.201805-0879OCDOI Listing
October 2018
28 Reads

Less known aspects of central hypothyroidism: Part 2 - Congenital etiologies.

J Clin Transl Endocrinol 2018 Dec 27;14:5-11. Epub 2018 Sep 27.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is <1:50,000, and on its etiology, disregarding CH caused by other genetic defects, such as mutations of transcription factors involved in pituitary organogenesis or mutations of the genes encoding TRH or TRH receptor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146237183006
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http://dx.doi.org/10.1016/j.jcte.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171088PMC
December 2018
19 Reads

Risk of Left Atrial Enlargement in Obese Patients With Obesity-Induced Hypoventilation Syndrome vs Obstructive Sleep Apnea.

Ochsner J 2018 ;18(2):136-140

Department of Interventional Cardiology, Wayne State University, Detroit Medical Center, Detroit, MI.

Background: Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF) that is principally driven by left atrial enlargement. The impact of hypoventilation caused by obesity-induced hypoventilation syndrome (OHS) on left atrial diameter has not been examined. We investigated the association between OHS and left atrial diameter in obese patients. Read More

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http://dx.doi.org/10.31486/toj.17.0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135280PMC
January 2018
5 Reads

Perioperative anesthetic management of children with congenital central hypoventilation syndrome and rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation undergoing thoracoscopic phrenic nerve-diaphragm pacemaker implantation.

Paediatr Anaesth 2018 11 24;28(11):963-973. Epub 2018 Sep 24.

Department of Pediatric Anesthesiology, Feinberg School of Medicine, Northwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Background: Congenital Central Hypoventilation Syndrome and Rapid-Onset Obesity with Hypothalamic dysfunction, Hypoventilation, and Autonomic Dysregulation are rare neurocristopathies characterized by autonomic dysregulation including bradyarrhythmias, abnormal temperature control, and most significantly, abnormal control of breathing leading to tracheostomy and ventilator dependence as life support. Surgical advancements have made phrenic nerve-diaphragm pacemakers available, to eliminate the tether to a mechanical ventilator for 12-15 hours each day. The thoracoscopic approach to implantation has allowed for a less invasive approach which may have implications for pain control and recovery time. Read More

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http://dx.doi.org/10.1111/pan.13475DOI Listing
November 2018
3 Reads

Inflammatory Markers in Patients Using Domiciliary Non-invasive Mechanical Ventilation: C Reactive Protein, Procalcitonin, Neutrophil Lymphocyte Ratio.

Front Public Health 2018 5;6:245. Epub 2018 Sep 5.

Health Sciences University Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Maltepe, Turkey.

Early identification and treatment of infections in patients using domiciliary non-invasive mechanical ventilation (NIMV) due to chronic respiratory failure (CRF) can reduce hospital admissions. We assessed C-reactive protein (CRP), procalcitonin, and neutrophil lymphocyte ratio (NLR) as indicators of infection/inflammation. The study was designed as a retrospective, observational, cross-sectional study, and was performed in 2016 in an intensive care unit outpatient clinic in patients using NIMV. Read More

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http://dx.doi.org/10.3389/fpubh.2018.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133955PMC
September 2018
4 Reads

A case scenario study for the assessment of physician's behavior in the management of COPD: the WHY study.

Int J Chron Obstruct Pulmon Dis 2018 5;13:2751-2758. Epub 2018 Sep 5.

Department of Chest Diseases, Ege University Medical Faculty, Izmir, Turkey.

Purpose: COPD diagnosis is mainly based on clinical judgment of physicians. Physicians do not also refer to COPD guidelines in their daily practice. This study aimed to assess attitudes of physicians regarding COPD diagnosis, treatment, and follow-up and to identify the factors influencing physicians' decisions in clinical practice. Read More

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http://dx.doi.org/10.2147/COPD.S154616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130535PMC
January 2019
11 Reads

A novel PHOX2B gene mutation in an extremely low birth weight infant with congenital central hypoventilation syndrome and variant Hirschsprung's disease.

Eur J Med Genet 2018 Sep 15. Epub 2018 Sep 15.

Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.

Congenital central hypoventilation syndrome is a disorder of respiratory control caused by mutations in the paired-like homeobox 2B gene. Mutations in the paired-like homeobox 2B gene are also responsible for Hirschsprung's disease. Variant Hirschsprung's disease is a rarer disorder that does not meet the diagnostic criteria of Hirschsprung's disease, although severe functional bowel obstruction persists. Read More

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http://dx.doi.org/10.1016/j.ejmg.2018.09.008DOI Listing
September 2018
3 Reads

Risk factors associated with obstructive sleep apnea-hypopnea syndrome in Chinese children: A single center retrospective case-control study.

PLoS One 2018 13;13(9):e0203695. Epub 2018 Sep 13.

Department of Otolaryngology, Fuzhou Children's Hospital of Fujian Province, Fujian Medical University Hospital, Fuzhou, China.

Pediatric obstructive sleep apnea-hypopnea syndrome is caused by multiple factors. The present study aimed to investigate the potential risks of pediatric obstructive sleep apnea hypopnea syndrome (OSAHS) and their correlation with the disease severity. A total of 338 pediatric patients with OSAHS (polysomnography (PSG) diagnosis) were enrolled between June 2008 and October 2010. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136758PMC
September 2018
2 Reads

Systemic oxidative stress in congenital central hypoventilation syndrome.

Eur Respir J 2018 Nov 15;52(5). Epub 2018 Nov 15.

Sleep Breathing Disorders and SIDS Center, Meyer Children's Hospital, Florence, Italy

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http://dx.doi.org/10.1183/13993003.01497-2018DOI Listing
November 2018
3 Reads

[The clinic experience of implantable diaphragm pacer in a patient with high cervical spinal cord injury and literature review].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Sep;41(9):718-723

Department of Spinal and Neural Function Reconstruction, Capital Medical University School of Rehabilitation Medicine(China Rehabilitation Research Center), Beijing 100068, China.

To report the use of implantable diaphragm pacer (IDP) in a patient with high cervical spinal cord injury(HCSCI). A 14-year-old male patient, who suffered from a HCSCI at C2 neurological level and had been on a ventilator for 2 years, received IDP in August 2017 at China Rehabilitation Research Center. A systematic literature review was performed on IDP in patients with HCSCI in Pubmed, CNKI, and Wanfang databases, using the keywords: phrenic nerve and electrical stimulation and spinal cord injury; IDP and spinal cord injury; breathing pacemaker system and spinal cord injury. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.09.013DOI Listing
September 2018
2 Reads

Obesity Hypoventilation Syndrome: Will Early Detection and Effective Therapy Improve Long-Term Outcomes?

J Clin Sleep Med 2018 Sep 15;14(9):1455-1457. Epub 2018 Sep 15.

Department of Medicine, Section of Pulmonary and Critical Care, Sleep Disorders Center, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.5664/jcsm.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134243PMC
September 2018
3 Reads

The Association Between Adherence to Positive Airway Pressure Therapy and Long-Term Outcomes in Patients With Obesity Hypoventilation Syndrome: A Prospective Observational Study.

J Clin Sleep Med 2018 Sep 15;14(9):1539-1550. Epub 2018 Sep 15.

Sleep Disorders Center, Department of Thoracic Medicine, University of Crete, Heraklion, Greece.

Study Objectives: To assess the role of different levels of adherence and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depressive symptoms, and all-cause mortality in patients with obesity hypoventilation syndrome (OHS).

Methods: A total of 252 patients with newly diagnosed OHS were followed up for a minimum of 2 years after PAP initiation. PAP adherence (h/night) was monitored. Read More

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http://dx.doi.org/10.5664/jcsm.7332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134255PMC
September 2018
2 Reads

Obesity Hypoventilation Syndrome: Early Detection of Nocturnal-Only Hypercapnia in an Obese Population.

J Clin Sleep Med 2018 Sep 15;14(9):1477-1484. Epub 2018 Sep 15.

Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; School of Medicine, University of Sydney, Sydney, Australia; Woolcock Institute of Medical Research, Sleep and Circadian Research Group, Sydney, Australia.

Study Objectives: Hypoventilation in obesity is now divided into five stages; stage 0 (pure obstructive sleep apnea; OSA), stages I/II (obesity-related sleep hypoventilation; ORSH) and stages III/IV (awake hypercapnia, obesity hypoventilation syndrome; OHS). Hypercapnia during the day may be preceded by hypoventilation during sleep. The goal of this study was to determine the prevalence and to identify simple clinical measures that predict stages I/II ORSH. Read More

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http://dx.doi.org/10.5664/jcsm.7318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134235PMC
September 2018
3 Reads

Coexistence of asthma and the obesity-hypoventilation syndrome.

Wiad Lek 2018;71(5):949-953

Department Of Pulmonology And Lung Cancer, Medical University In Wroclaw, Wroclaw, Poland.

Objective: Introduction: With the increasing problem of obesity in the world, high prevalence of asthma in obese persons and high prevalence of sleep breathing disorders related to obesity, the number of patients with coexisting asthma and obesity hypoventilation syndrome is likely to increase. The aim: To evaluate long-term effects of obesity hypoventilation syndrome treatment in the patients with concomitant asthma.

Patients And Methods: Materials and methods: Obesity hypoventilation syndrome was diagnosed in six adult patients with asthma (body mass index 43. Read More

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January 2018
3 Reads

[Obstructive sleep apnea hypopnea syndrome and alveolar hypoventilation syndrome in motor neuron disease: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):106-112

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To investigate the clinical characteristics of a patient with motor neuron disease, which caused sleep-disordered breathing (SDB) and alveolar hypoventilation syndrome, and to improve the diagnosis rate for this disease.
 Methods: Retrospectively analyze the diagnosis and treatment process for a 52 year-old male patient, who was accepted by the Second Xiangya Hospital, Central South University because of dyspnea, shortness of breath and malaise for 4 months, and eventually was diagnosed as motor neuron disease associated with obstructive sleep apnea hypopnea syndrome and alveolar hypoventilation syndrome. In addition, we searched CNKI, Wanfang and PubMed databases to review relevant literature with keywords (motor neuron disease or amyotrophic lateral sclerosis or progressive bulbar palsy or progressive muscular atrophy or primary lateral sclerosis) AND (sleep apnea or sleep disordered breathing) from January 1990 to May 2017. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.01.017DOI Listing
January 2018
9 Reads

Severe Positional Central Sleep Apnea in an Asymptomatic Adult With a Frameshift Mutation.

J Clin Sleep Med 2018 Aug 15;14(8):1427-1430. Epub 2018 Aug 15.

Sleep Medicine Center Kempenhaeghe, Heeze, The Netherlands.

Abstract: We report an unusual case of an adult patient carrying a germline frameshift mutation and hence was diagnosed with congenital central hypoventilation syndrome. He came to medical attention after the mutation was identified in his daughter who presented with hypoventilation and a neuroblastoma. Although mutations are usually associated with a phenotype of congenital hypoventilation, severe autonomic dysfunction and neural crest tumors, our patient had no complaints at the time of presentation. Read More

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http://jcsm.aasm.org/ViewAbstract.aspx?pid=31359
Publisher Site
http://dx.doi.org/10.5664/jcsm.7290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086954PMC
August 2018
15 Reads

[Association between hypothyroidism and sleep breathing disorders in patients with coronary heart disease].

Zhonghua Nei Ke Za Zhi 2018 Aug;57(8):571-575

Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To explore the association between hypothyroidism and sleep breathing disorders in patients with coronary heart disease (CHD). A total of 784 patients with CHD were consecutively enrolled at the Emergency & Critical Care Center of Beijing Anzhen Hospital from June 2015 to May 2017. According to thyroid function test results, patients were divided into hypothyroidism group (79 cases) and non-hypothyroidism group (705 cases). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2018.08.007DOI Listing
August 2018
1 Read

[Sleep-disordered breathing in motor neuron disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(4. Vyp. 2):119-123

Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus.

Aim: To study sleep-disordered breathing (SDB) in patients with motor neuron disease (MND).

Material And Methods: Ninety-two patients, 50 women and 42 men, were examined Median age was 62 [55; 67.5] years, MND duration 12 [8. Read More

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http://dx.doi.org/10.17116/jnevro201811842119DOI Listing
January 2018
1 Read