471 results match your criteria Hypothyroidism and Myxedema Coma

New-Onset Hypothyroidism Manifesting As Myxedema Coma: Fighting an Old Enemy.

Cureus 2022 Apr 6;14(4):e23881. Epub 2022 Apr 6.

Endocrinology, Saint Peter's University Hospital, New Brunswick, USA.

Myxedema coma (MC) is a rare manifestation of severe hypothyroidism. This is a true endocrine emergency that may remain unrecognized. We present a case of a 49-year-old man who presented to the emergency department with generalized weakness and confusion. Read More

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Myxedema Coma Associated with Macroprolactinoma: Case Report and Review of the Literature.

Case Rep Endocrinol 2022 28;2022:1591616. Epub 2022 Apr 28.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Houston Methodist Hospital, Houston, TX, USA.

Myxedema coma is a rare life-threatening presentation of severe hypothyroidism associated with a high mortality rate. Although most cases are due to primary thyroid failure, a minority have central hypothyroidism as the underlying cause. We report the case of a 69-year-old man who presented with obtundation, hypoglycemia, and hyponatremia. Read More

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Initial treatment of myxedema coma using oral levothyroxine: a case report from Tanzania.

Endocrinol Diabetes Metab Case Rep 2022 Apr 1;2022. Epub 2022 Apr 1.

Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Summary: Myxedema coma is a severe complication of hypothyroidism, commonly affecting women over 60 years of age, causing slow, progressive multi-organ dysfunction, and mental deterioration. Due to improved diagnostics and treatment of hypothyroidism, myxedema coma has become uncommon. However, it is hardly reported in resource-limited settings. Read More

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A case of fatal myxedema coma with electrocardiogram Osborne J-wave in a patient initially diagnosed with hypothyroidism.

Endocr J 2022 Apr 9. Epub 2022 Apr 9.

Department of Internal Medicine, Uwajima City Hospital, Ehime 798-8510, Japan.

Myxedema coma is a life-threatening endocrine emergency with a high mortality rate resulting from severe insufficiency of thyroid hormones. Intravenous levothyroxine replacement is considered the standard therapy for myxedema coma in many countries. In Japan, however, although there are diagnostic criteria highly suggestive or diagnostic for myxedema coma, no management strategy has been established, despite the availability of levothyroxine. Read More

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Systematic review of COVID-19 and autoimmune thyroiditis.

Travel Med Infect Dis 2022 May-Jun;47:102314. Epub 2022 Mar 18.

Department of Infectious Diseases, VM Medicalpark Samsun Hospital, Samsun, Turkey. Electronic address:

COVID-19 is a severe acute respiratory syndrome. Recent reports showed that autoimmune thyroiditis might occur following COVID-19 infection. We aimed to review the literature to assess the prevalence, clinical features and outcome of autoimmune thyroid disorders triggered by COVID-19. Read More

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Case Report: Myxedema Coma Caused by Immunoglobulin A Vasculitis in a Patient With Severe Hypothyroidism.

Front Immunol 2022 18;13:838739. Epub 2022 Feb 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Myxedema coma is a critical disorder with high mortality rates. Disruption of the compensatory mechanism for severe and long-term hypothyroidism by various causes leads to critical conditions, including hypothermia, respiratory failure, circulatory failure, and central nervous system dysfunction. Infectious diseases, stroke, myocardial infarction, sedative drugs, and cold exposure are considered the main triggers for myxedema coma. Read More

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Thyroid and Parathyroid Conditions: Hypothyroidism.

FP Essent 2022 Mar;514:18-23

Department of Family Medicine - College of Medicine - Medical University of South Carolina, 135 Cannon St Suite 405 MSC 192, Charleston, SC 29425.

Hypothyroidism is caused by deficient thyroid hormone production secondary to autoimmune disease or insufficient iodine consumption or as a complication of hyperthyroidism management. Signs and symptoms include fatigue, weight gain, dry skin, constipation, and cold intolerance. The U. Read More

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Myxedema Coma Precipitated by Iohexol: Case Report and Brief Literature Review on the Wolff-Chaikoff Effect.

Thyroid 2022 Mar 22. Epub 2022 Mar 22.

Department of Endocrinology, National University Hospital, University Medicine Cluster; National University Health System, Singapore.

Failure to escape from the Wolff-Chaikoff effect (WCE) causes hypothyroidism. This is the first report of myxedema coma after iohexol administration. The failure of the escape phenomenon in this patient was longer than existing reports. Read More

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Status Epilepticus as a Life-Threatening Manifestation of Myxedema Crisis.

Cureus 2022 Jan 12;14(1):e21155. Epub 2022 Jan 12.

Internal Medicine, St. Vincent Charity Medical Center, Cleveland, USA.

Myxedema coma is a rare life-threatening emergency that usually presents in the elderly during the winter months. The neurological changes caused by uncontrolled hypothyroidism may precipitate seizure activity and its deleterious consequences. A 65-year-old homeless man with a history of non-Hodgkin lymphoma in remission for over 20 years presented to the emergency department (ED) following an episode of syncope. Read More

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January 2022

A Rare Case of Hypoparathyroidism and Myxedema Coma in a Patient With Diamond-Blackfan Anemia.

Cureus 2021 Nov 27;13(11):e19941. Epub 2021 Nov 27.

Internal Medicine, Northwell Health, New York, USA.

Diamond-Blackfan anemia (DBA) is a rare genetic condition that presents due to bone marrow failure caused by a dysfunction in ribosomal biogenesis and function. The patients would often require chronic transfusions as treatment, which puts them at high risk for the development of secondary hemochromatosis. This secondary hemochromatosis results in endocrinopathies due to iron deposition into the endocrine glands. Read More

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November 2021

The Abnormal Sinus Rhythm: Myxedema Coma Complicated by Subacute Cardiac Tamponade.

Cureus 2021 Nov 13;13(11):e19535. Epub 2021 Nov 13.

Cardiology, Veterans Affairs New York Harbor Healthcare System, Brooklyn Campus, Brooklyn, USA.

Subacute cardiac tamponade (SCT) is a potentially life-threatening condition that requires immediate medical attention. Combining careful history taking, focused physical exam, and the use of point of care ultrasound (POCUS) for early diagnosis with aggressive management can minimize potential complications. In patients with severe hypothyroidism and myxedema coma, clinical signs of cardiac tamponade may be masked and lead to delayed diagnosis. Read More

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November 2021

Sudden cardiac arrest associated with myxedema coma due to undiagnosed hypothyroidism: a case report.

BMC Endocr Disord 2021 Nov 17;21(1):229. Epub 2021 Nov 17.

Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1West 16, Chuo-ku, 060-8543, Sapporo, Hokkaido, Japan.

Background: Myxedema coma, which occurs due to hypothyroidism, is a rare and life-threatening condition. Some patients have hemodynamic dysfunction, which consequently leads to cardiac arrest. The rarity of this condition makes it difficult to determine the cause of cardiac arrest. Read More

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November 2021

Myxedema Coma and Acute Hepatopathy in a Dog with Severe Atherosclerosis.

Case Rep Vet Med 2021 29;2021:6622767. Epub 2021 Oct 29.

Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, USA.

A 9-year-old male intact mixed-breed dog was presented to The Ohio State University Veterinary Medical Center for evaluation of two days' duration of weakness, lethargy, inappetence, and one episode of vomiting the day of presentation. On presentation, the dog was depressed and tetraparetic. He was noted to be icteric and dehydrated. Read More

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October 2021

The Myxedema coma in children and adolescents: A rare endocrine emergency - Personal experience and review of literature.

Acta Biomed 2021 11 3;92(5):e2021481. Epub 2021 Nov 3.

First Department of Pediatrics, National Kapodistrian University of Athens, Greece.

Decompensated hypothyroidism, formerly known as myxedema coma, represents the most extreme clinical expression of severe primary or secondary hypothyroidism in which patients exhibit multiple organ abnormalities and progressive mental deterioration. The exact incidence of myxedema coma in adults is not known, but some authors have estimated that is approximately 0.22 per 100. Read More

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November 2021

Myxoedema coma caused by immunotherapy-related thyroiditis and enteritis.

Endocrinol Diabetes Metab Case Rep 2021 Oct 1;2021. Epub 2021 Oct 1.

Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

Summary: Thyroid dysfunction is among the most common immune-related adverse reactions associated with immune checkpoint inhibitors. It most commonly manifests as painless thyroiditis followed by permanent hypothyroidism. This usually causes mild toxicity that does not interfere with oncological treatment. Read More

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October 2021

A Patient with Recurrent Myxedema Coma: What Was the Missing Link?

Am J Med 2022 03 29;135(3):393-396. Epub 2021 Sep 29.

Department of General Medicine, Sengkang General Hospital, Singapore. Electronic address:

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A Case of Myxedema Coma Crisis Induced by Inhalation Injury.

Cureus 2021 Aug 10;13(8):e17049. Epub 2021 Aug 10.

Internal Medicine, Lincoln Medical Center, New York, USA.

Myxedema coma is a life-threatening, critical condition in which many organ systems can be severely affected. It is considered the most severe presentation of hypothyroidism and should be treated immediately. Here, we discuss the case of a 58-year-old patient who presented with altered mental status, bradycardia, and hypothermia, the critical characteristics considered in this disorder after inhalation injury. Read More

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Oral Levothyroxine Treatment in Lithium Intoxication- Induced Myxedema Coma: A Case Report.

Po-Hsuan Kao

J Acute Med 2021 Jun;11(2):68-71

National Taiwan University Hospital Department of Emergency Medicine Taipei Taiwan.

Lithium intoxication-induced myxedema coma, a rare but dangerous condition of severe hypothyroidism, can be easily misdiagnosed in patients without history of hypothyroidism. The objective of this case report is to describe a lithium-treated patient who presented to emergency department with obtundation and moderate hypothermia and was diagnosed with myxedema coma and lithium toxicity. A 64-year-old female presented to the emergency department with obtundation and hypothermia. Read More

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Myxedema Coma: Case Report and Literature Review.

Cureus 2021 May 27;13(5):e15277. Epub 2021 May 27.

Internal Medicine, Rutgers-New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA.

Myxedema coma is a life-threatening manifestation of hypothyroidism associated with altered mental status, hypothermia, and symptoms related to the slowing of other organ systems. It can occur as a culmination of severe, longstanding hypothyroidism or be precipitated by acute stressors such as infection, myocardial infarction, cold exposure, and surgery in patients with poorly controlled hypothyroidism. Given the high mortality rate and acuity with which the disease presents, treatment with thyroid hormone replacement should be initiated upon suspicion of the disease even prior to obtaining laboratory confirmation. Read More

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A Rare Case of Myxedema Coma Presenting as Bradycardia and Hypotension Secondary to Pituitary Apoplexy.

Cureus 2021 May 23;13(5):e15196. Epub 2021 May 23.

Cardiology, East Tennessee State University, Johnson City, USA.

Myxedema coma and pituitary apoplexy are well-known life-threatening endocrine emergencies. The coincidence of these entities is exceedingly rare. Myxedema coma occurring as a result of pituitary lesion is a much less seen entity. Read More

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Myxedema coma complicated by bilateral hygromas.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway.

Summary: Myxedema coma is an important differential diagnosis in critically ill patients. Early diagnosis and treatment are paramount but challenging due to a lack of diagnostic criteria. We report a case about a patient who suffered from untreated hypothyroidism for several years. Read More

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Hypothyroidism: Diagnosis and Treatment.

Am Fam Physician 2021 05;103(10):605-613

University of Pittsburgh Medical Center St. Margaret Family Medicine Residency Program, Pittsburgh, PA, USA.

Clinical hypothyroidism affects one in 300 people in the United States, with a higher prevalence among female and older patients. Symptoms range from minimal to life-threatening (myxedema coma); more common symptoms include cold intolerance, fatigue, weight gain, dry skin, constipation, and voice changes. The signs and symptoms that suggest thyroid dysfunction are nonspecific and nondiagnostic, especially early in disease presentation; therefore, a diagnosis is based on blood levels of thyroid-stimulating hormone and free thyroxine. Read More

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Neurological Complications of Endocrine Emergencies.

Curr Neurol Neurosci Rep 2021 03 11;21(5):21. Epub 2021 Mar 11.

Department of Neurology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose Of Review: Endocrine disorders are the result of insufficient or excessive hormonal production. The clinical course is long, and the manifestations are nonspecific due to the systemic effect of hormones across many organs and systems including the nervous system. This is a narrative review of the recent evidence of the diagnosis and treatment approach of these medical and neurological emergencies. Read More

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An Unusual Presentation of ST Elevation Myocardial Infarction Complicated with Cardiogenic Shock Due to Myxedema Coma: A Case Report.

Am J Case Rep 2021 Mar 10;22:e929573. Epub 2021 Mar 10.

Department of Cardiology, United Health Services Hospitals, Wilson Regional Medical Center, Johnson City, NY, USA.

BACKGROUND Myxedema coma is an endocrine emergency with a high mortality rate, defined as a severe hypothyroidism leading to hypotension, bradycardia, decreased mental status, hyponatremia, hypoglycemia, and cardiogenic shock. Although hypothyroidism and cardiac disease has been interlinked, ST elevation myocardial infarction in the setting of myxedema coma have not been reported previously. CASE REPORT We report the case of a 70-year-old man who presented to the Emergency Department with chest pain and confusion. Read More

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[A case of elderly myxedema coma patient with end-stage renal failure].

Nihon Ronen Igakkai Zasshi 2021 ;58(1):152-157

Department of Endocrinology & Metabolism, Takagi Hospital.

Case: 84-year-old woman had been diagnosed hypothyroidism before, but she did not take tablets of thyroid hormone prescribed. Anorexia and decreased consciousness level were discovered by workers of the facility. Her family doctor found thyroid function abnormality as a cause, and she was introduced to our hospital to treat because the whole body condition was bad. Read More

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February 2021

Clinical manifestation and images of a patient having cardiovascular involvement in myxoedema coma.

Med J Armed Forces India 2021 Jan 15;77(1):92-95. Epub 2019 Apr 15.

Junior Resident (Medicine), Command Hospital (Central Command), Lucknow Cantt, India.

Myxoedema coma is an endocrine emergency characterised by diminished sensorium associated with features of severe hypothyroidism. The disease carries a high mortality of 30%-60 %. The cardiac manifestation of the disease consists of bradycardia, hypotension, pericardial effusion and certain echocardiographic changes such as heart block and features of hypothermia. Read More

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January 2021

Congenital hypothyroidism presenting as myxedema coma in a teenager.

Am J Emerg Med 2021 07 13;45:688.e1-688.e2. Epub 2021 Jan 13.

Division of Pediatric Emergency Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

Congenital hypothyroidism is rare and is screened for in the United States during the newborn period in order to prevent a treatable cognitive delay. Myxedema coma is a complication due to severe hypothyroidism resulting from failure of homeostatic processes, causing altered mental status, generalized edema, and vital sign abnormalities. Treatment of myxedema coma consists of supportive care and hormone replacement. Read More

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Legions of Presentations of Myxedema Coma: A Case Series from a Tertiary Hospital in India.

J ASEAN Fed Endocr Soc 2020 29;35(2):233-237. Epub 2020 Nov 29.

Department of Internal Medicine, KPC Medical College and Hospital, West Bengal University of Health Sciences, Kolkata, India.

Myxedema coma is associated with decreased mental status and hyponatremia among patients with diagnosed or undiagnosed hypothyroidism. The diagnosis is challenging in the absence of universally accepted diagnostic criteria, but should be considered as a differential even in cases with competing established diagnoses. All patients should receive intensive care level treatment. Read More

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November 2020

Myxedema Coma: A Life-Threatening Condition in Patients Using Pembrolizumab.

Case Rep Endocrinol 2020 22;2020:8855943. Epub 2020 Oct 22.

Berkshire Medical Center, 725 North Street, Pittsfield, MA 01201, USA.

The advent of immune checkpoint inhibitors has significantly improved the prognosis of patients with advanced malignancies. As we begin to understand these medications, multiple immune-related adverse effects (irAEs) have been found with these drugs, including endocrinopathies. Understanding the treatment-related adverse events of these medications is critical for clinical practice. Read More

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October 2020

Myxedema Coma: A Forgotten Medical Emergency With a Precipitous Onset.

Cureus 2020 Sep 16;12(9):e10478. Epub 2020 Sep 16.

Internal Medicine, Campbell University School of Osteopathic Medicine, Buies Creek, USA.

Myxedema coma is a rare life-threatening disorder characterized by severe hypothyroidism leading to multiorgan failure and even death. This case also reminds clinicians that the misnomer "coma" is misleading, and the patient can present with less severe symptoms. We present a case of a 72-year-old female with a history of primary hypothyroidism who presented to the emergency department with progressively worsening confusion for three days. Read More

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September 2020