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    379 results match your criteria Hypothyroidism and Myxedema Coma

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    Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan.
    J Epidemiol 2017 Jan 5. Epub 2017 Jan 5.
    Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
    Background: Myxedema coma is a life-threatening and emergency presentation of hypothyroidism. However, the clinical features and outcomes of this condition have been poorly defined because of its rarity.

    Methods: We conducted a retrospective observational study of patients diagnosed with myxedema coma from July 2010 through March 2013 using a national inpatient database in Japan. Read More

    Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis.
    J Am Osteopath Assoc 2017 Jan;117(1):50-54
    Myxedema psychosis is uncommon in patients with primary hypothyroidism. Most often, this disease state can be found in patients with Hashimoto thyroiditis or after total thyroidectomy. Chronic hypothyroidism can lead to an insidious onset of psychiatric symptoms in patients, such as dementia, delirium, psychosis, hallucinations, and coma. Read More

    An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure.
    Case Rep Crit Care 2016 30;2016:3438080. Epub 2016 Oct 30.
    Pulmonary and Critical Care, St. John's Riverside Hospital, 967 N. Broadway, Yonkers, NY 10701, USA.
    Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Read More

    Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics.
    Horm Res Paediatr 2016 Sep 16. Epub 2016 Sep 16.
    Section of Endocrinology, Metabolism and Diabetes, Nationwide Children's Hospital, Columbus, Ohio, USA.
    Background: Myxedema coma (MC), a medical emergency defined as severe hypothyroidism leading to altered mental status, is more common in older women with hypothyroidism.

    Methods/results: A 7-year-old Caucasian male with chromosome 1q deletion presented with altered mental status preceded by milestone regression. His presenting labs results were: thyroid-stimulating hormone (TSH) 0. Read More

    Pediatric Patient With Altered Mental Status and Hypoxemia: Case Report.
    Pediatr Emerg Care 2016 Apr 5. Epub 2016 Apr 5.
    From the *Department of Pediatrics, University of Pittsburgh School of Medicine; †Department of Pediatrics, Children's Hospital of Pittsburgh; ‡Division of Pediatric Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine; and §Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
    Childhood cases of myxedema coma are extremely rare. We report a case of a 5-year-old girl transferred to a tertiary care pediatric emergency department with hypoxemia and altered mental status and diagnosed with severe hypothyroidism and myxedema coma in the setting of acute influenza infection. Although it is rare, myxedema coma must remain in the differential diagnosis for altered mental status and organ dysfunction in the pediatric population. Read More

    A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy.
    Endocr J 2016 Jun 26;63(6):523-32. Epub 2016 Mar 26.
    Department of General Medicine, National Defense Medical College, Tokorozawa, Japan.
    Myxedema coma (MC) is a life-threatening endocrine crisis caused by severe hypothyroidism. However, validated diagnostic criteria and treatment guidelines for MC have not been established owing to its rarity. Therefore, a valid animal model is required to investigate the pathologic and therapeutic aspects of MC. Read More

    Precision Medicine Comes to Thyroidology.
    J Clin Endocrinol Metab 2016 Mar 23;101(3):799-803. Epub 2016 Feb 23.
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0003.
    Context: The broad spectrum of thyroid disease severity--from subclinical hypothyroidism to myxedema coma, subclinical thyrotoxicosis to thyroid storm, and microscopic papillary to anaplastic cancers--has always demanded that clinicians individualize their management of thyroid patients. Deepening knowledge of thyroid pathophysiology along with advances in diagnostic, prognostic, and therapeutic technologies applicable to thyroid diseases position this field to ride the wave of precision medicine in the decade ahead. Read More

    Myxoedema coma in the setting of hyperglycaemic hyperosmolar state.
    BMJ Case Rep 2016 Jan 11;2016. Epub 2016 Jan 11.
    Anaesthesia and Critical Care, Tameside Hospital NHS Foundation Trust, Lancashire, UK.
    Decompensated hypothyroidism is a rare endocrine emergency but a differential that should be considered in patients presenting critically unwell with systemic illness. We report a case of myxoedema coma in a woman presenting with respiratory failure, hypotension, hypothermia and a reduced level of consciousness, all of which are poor prognostic features in decompensated hypothyroidism. The patient was admitted to critical care for mechanical ventilation and cardiovascular support and treated with a combination of insulin, liothyronine and levothyroxine, making a good recovery. Read More

    Weekly Intramuscular Injection of Levothyroxine following Myxoedema: A Practical Solution to an Old Crisis.
    Case Rep Endocrinol 2015 5;2015:169194. Epub 2015 Nov 5.
    Endocrinology and Diabetes Department, Prince Charles Hospital, Cwm Taf University Health Board, Merthyr Tydfil CF47 9DT, UK.
    An 82-year-old female with known hypothyroidism was admitted to hospital after being found on the floor. On examination, she was unkempt, confused, bradycardic, hypothermic, and barely arousable. Initial biochemistry revealed a thyroid stimulating hormone (TSH) of >100 mU/L and free thyroxine (FT4) level of 1. Read More

    Myxedema coma with cardiac tamponade and severe cardiomyopathy.
    Proc (Bayl Univ Med Cent) 2015 Oct;28(4):509-11
    Department of Internal Medicine (Majid-Moosa), the Division of Cardiology (Schussler), and the Division of Pulmonary and Critical Care Medicine (Mora), Baylor University Medical Center at Dallas; the Jack and Jane Hamilton Heart and Vascular Hospital (Schussler); and the Texas A&M College of Medicine (Schussler).
    Myxedema coma is an infrequent but potentially fatal complication of hypothyroidism. We present a rare case of previously undiagnosed hypothyroidism presenting in cardiogenic shock from pericardial tamponade and depressed myocardial contractility in myxedema coma. Here, we focus on cardiovascular complications associated with the condition. Read More

    A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS).
    J Clin Diagn Res 2015 May 1;9(5):VD01-VD03. Epub 2015 May 1.
    DNB Resident, Department of Psychiatry, Base Hospital , Delhi Cantt, India .
    Myxedema coma or hypothyroid crisis is an endocrine emergency and needs ICU management. Neuroleptic malignant syndrome (NMS) is another medical emergency which needs high degree of clinical suspicion else mortality can be high. There is a paradox in co existence of myxedema coma and NMS. Read More

    Complete recovery after severe myxoedema coma complicated by status epilepticus.
    BMJ Case Rep 2015 Mar 25;2015. Epub 2015 Mar 25.
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark.
    We report a case of life-threatening myxoedema presenting with hypothermia, hypotension, bradycardia, pericardial effusion and deep coma. The condition was complicated by prolonged status epilepticus. The optimal treatment strategy has been debated over the years and the literature is briefly reviewed. Read More

    Development of an objective tool for the diagnosis of myxedema coma.
    Transl Res 2015 Sep 13;166(3):233-43. Epub 2015 Jan 13.
    Department of Medicine, Indiana University School of Medicine and Methodist Research Institute, Indianapolis, Ind. Electronic address:
    Myxedema coma, a rare entity, with a reported 25%-65% mortality had no objective criteria for making the diagnosis when we began our study. We developed an objective screening tool for myxedema coma to more easily identify patients and examine the best treatment method in future prospective studies to reduce the mortality of this entity. We conducted a retrospective chart review to find all patients aged ≥18 years admitted with myxedema coma from January 1, 2005 through June 13, 2010 at Indiana University Health Methodist Hospital. Read More

    Hashimoto's encephalopathy: report of three cases.
    J Formos Med Assoc 2014 Nov 3;113(11):862-6. Epub 2012 Mar 3.
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
    Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Read More

    Lithium toxicity and myxedema crisis in an elderly patient.
    Indian J Endocrinol Metab 2013 Dec;17(Suppl 3):S654-6
    Department of Endocrinology, Sheri-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
    Unlabelled: While thyroid dysfunction is a frequent complication of lithium treatment, myxedema crisis is a rare occurrence with a handful of cases described. Here, we describe a patient receiving lithium for about a decade for bipolar disorder, who presented with myxedema crisis and lithium toxicity. In this patient, myxedema crisis was likely precipitated by lithium toxicity and community acquired pneumonia. Read More

    Hypothyroidism: causes, killers, and life-saving treatments.
    Emerg Med Clin North Am 2014 May 6;32(2):303-17. Epub 2014 Mar 6.
    Emergency Medicine Residency Program, University of Maryland Medical Center, 110 South Paca Street, 6th Floor Suite 200, Baltimore, MD 21201, USA.
    Hypothyroidism is a very common, yet often overlooked disease. It can have a myriad of signs and symptoms, and is often nonspecific. Identification requires analysis of thyroid hormones circulating in the bloodstream, and treatment is simply replacement with exogenous hormone, usually levothyroxine (Synthroid). Read More

    Amiodarone-induced myxoedema coma.
    BMJ Case Rep 2014 Apr 12;2014. Epub 2014 Apr 12.
    Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
    A 62-year-old man was found to have bradycardia, hypothermia and respiratory failure 3 weeks after initiation of amiodarone therapy for atrial fibrillation. Thyroid-stimulating hormone was found to be 168 μIU/mL (nl. 0. Read More

    Heart failure presenting as myxedema coma: case report and review article.
    Tenn Med 2014 Feb;107(2):39-41
    Department of Cardiovascular Disease, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
    Hypothyroidism is a common medical problem easily treated when diagnosed but requiring regular follow-up and patient medication compliance. At times, this diagnosis can go untreated resulting in the development of severe consequences such as Myxedema Coma. Of all the clinical symptoms, cardiovascular manifestations tend to be especially severe and often life threatening. Read More

    [Hypothyroidism after radiotherapy of the neck area: monitoring of thyroid function is important].
    Ned Tijdschr Geneeskd 2014 ;158:A6714
    Universitair Medisch Centrum Groningen, Groningen.
    We present three patients with primary hypothyroidism after previous radiotherapy of the neck area. Myxoedema coma occurred in one of these patients. Lifelong follow-up of thyroid function is recommended after radiotherapy of the neck. Read More

    Postoperative myxoedema coma.
    BMJ Case Rep 2014 Feb 13;2014. Epub 2014 Feb 13.
    Department of Medicine, Maharishi Markandeshwar Medical College and Hospital, Solan, Solan, Himachal Pradesh, India.
    Hypothyroidism is a commonly diagnosed endocrine disorder in medicine. Hyponatraemia is reported in up to 10% of hypothyroid patients, although it is usually mild and rarely causes symptoms. Myxoedema coma is a rare manifestation of hypothyroidism and it can be lethal if it goes undiagnosed and untreated. Read More

    A diagnostic scoring system for myxedema coma.
    Endocr Pract 2014 Aug;20(8):808-17
    Division of Endocrinology, Department of Medicine, MedStar Washington Hospital Center, Washington DC.
    Objective: To develop diagnostic criteria for myxedema coma (MC), a decompensated state of extreme hypothyroidism with a high mortality rate if untreated, in order to facilitate its early recognition and treatment.

    Methods: The frequencies of characteristics associated with MC were assessed retrospectively in patients from our institutions in order to derive a semiquantitative diagnostic point scale that was further applied on selected patients whose data were retrieved from the literature. Logistic regression analysis was used to test the predictive power of the score. Read More

    Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure.
    BMJ Case Rep 2014 Jan 30;2014. Epub 2014 Jan 30.
    Department of Nephrology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
    A 48-year-old man was admitted to department of emergency medicine at a tertiary referral hospital due to dizziness and fatigue. Clinical features on admission were non-pitting oedema, dry skin, very sparse hair, a hoarse voice, hypothermia (rectal temperature 28.7°C), macroglossia, sinus bradycardia and slow cerebration. Read More

    [Myxedema coma in a patient with type 1 neurofibromatosis: rare association].
    Arq Bras Endocrinol Metabol 2013 Dec;57(9):743-7
    Myxedema coma, a rare but fatal emergency, is an extreme expression of hypothyroidism. We describe a 51-year-old male patient who has discontinued hypothyroidism treatment 10 months earlier and developed lethargy, edema, and cold intolerance symptoms. He also had a previous diagnosis of neurofibromatosis. Read More

    Thyroid disease and the nervous system.
    Handb Clin Neurol 2014 ;120:703-35
    Sheffield Institute for Translational Neuroscience, University of Sheffield and Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK. Electronic address:
    Thyroid disorders are common in the general population and in hospitalized patients. Thyroid disease may present first with neurological complications or else may occur concurrently in patients suffering other neurological disorders, particularly those with an autoimmune etiology. For this reason neurologists will commonly encounter patients with thyroid disease. Read More

    Cardiac tamponade as initial presenting feature of primary hypothyroidism in the ED.
    Am J Emerg Med 2014 Jun 26;32(6):683.e1-3. Epub 2013 Nov 26.
    Department of Emergency Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Electronic address:
    Pericardial effusion is commonly detected in patients with severe hypothyroidism and is typically mild; rarely, it may lead to cardiac tamponade. Cardiac tamponade with myxedema coma as initial presenting feature of previously unrecognized hypothyroidism is rare. This case highlights that previously undiagnosed hypothyroidism can manifest as myxedema coma with shock due to pericardial tamponade particularly in winters because a cold environment can precipitate myxedema. Read More

    Use and misuse of thyroid hormone.
    Singapore Med J 2013 Jul;54(7):406-10
    Department of Endocrinology and Diabetes, The Alfred, 5th Floor, Centre Block, 55 Commercial Road, Melbourne, Victoria 3004, Australia.
    Synthetic thyroxine has replaced animal thyroid gland extract as the preferred drug in chronic thyroid hormone replacement. Synthetic thyroxine monotherapy is used to treat overt primary and secondary hypothyroidism, and some cases of subclinical hypothyroidism. In addition, thyroid-stimulating hormone suppressive therapy with thyroxine is a component of the chronic treatment for differentiated thyroid carcinoma. Read More

    Thyroid gland disorder emergencies: thyroid storm and myxedema coma.
    AACN Adv Crit Care 2013 Jul-Sep;24(3):325-32
    Inpatient Diabetes Management, University of Minnesota Physicians, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
    Although thyroid dysfunction will develop in more than 12% of the US population during their lifetimes, true thyroid emergencies are rare. Thyroid storm and myxedema coma are endocrine emergencies resulting from thyroid hormone dysregulation, usually coupled with an acute illness as a precipitant. Careful assessment of risk and rapid action, once danger is identified, are essential for limiting morbidity and mortality related to thyroid storm and myxedema coma. Read More

    Electromyographic evaluation of blink reflex as a tool for early diagnosis of neurological dysfunction in patients of hypothyroidism.
    Ann Neurosci 2013 Jul;20(3):95-8
    Department of Neurology, SBKS Medical Institute and Research Centre, Vadodara, Gujarat, INDIA.
    Background: Neurological dysfunction is an important consequence of hypothyroidism. Some of the neurologic manifestations of hypothyroidism include somnolence, lethargy, impaired memory and concentration, depression and entrapment neuropathy. Rarer but reversible neurological manifestations include cerebellar ataxia, psychosis, dementia and myxedema coma. Read More

    Pituitary hyperplasia: a complication of the pseudomalabsorption of thyroxine.
    Int J Gen Med 2013 29;6:335-9. Epub 2013 Apr 29.
    Division of Endocrinology, University of Ottawa, Ottawa, ON, Canada.
    Objective: "The pseudomalabsorption of thyroxine" has been used to describe patients with hypothyroidism who fail to comply with their treatment. We describe a unique case of a 32-year-old with hypothyroidism who developed pituitary hyperplasia and hyperprolactinemia secondary to the pseudomalabsorption of thyroxine.

    Investigations And Treatment: After baseline thyroid-function tests were performed, the patient was administered levothyroxine 0. Read More

    Heart failure presenting as myxedema coma: case report and review article.
    Tenn Med 2013 May;106(5):39-40
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37615, USA.
    Hypothyroidism is a common medical problem easily treated when diagnosed but requiring regular follow-up and patient medication compliance. At times, this diagnosis can go untreated resulting in the development of severe consequences such as Myxedema Coma. Of all the clinical symptoms, cardiovascular manifestations tend to be especially severe and often life threatening. Read More

    Perioperative management of a patient with myxedema coma and septicemic shock.
    Indian J Crit Care Med 2012 Oct;16(4):228-30
    Department of Anaesthesiology and Intensive Care, Lady Hardinge Medical College and Association Hospitals, New Delhi, India.
    Myxedema coma is a life-threatening but uncommon complication of long-standing, neglected hypothyroidism. It was first reported by Ord in 1879. Till date only around 200 cases have been reported in literature. Read More

    Severe hypothyroidism presenting as myxedema coma in the postoperative period in a patient taking sunitinib: case report and review of literature.
    J Clin Anesth 2013 Feb 16;25(1):47-51. Epub 2012 Dec 16.
    Department of Anesthesiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
    The case of a 62-year-old Caucasian woman who underwent urgent hip hemiarthroplasty for repair of a pathological fracture is reported. The patient's medical history was significant for renal cell carcinoma, cerebellar metastases, and sunitinib-induced hypothyroidism. Her intraoperative course was complicated by profound hypothermia, bradycardia, augmentation of neuromuscular blockade, delayed emergence, failure of postoperative extubation, and need for mechanical ventilation. Read More

    [The diagnosis and treatment of myxedema coma].
    Nihon Rinsho 2012 Nov;70(11):1995-9
    Department of Endocrinology and Metabolism, Dokkyo Medical University.
    Myxedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to dysfunction in multiple organs. It is very rare disease with high mortality rate. Early recognition and therapy of myxedema coma are essential, and treatment should be begun on the basis of clinical suspection. Read More

    [General thoracic surgery and perioperative management in the patients with endocrine dysfunction].
    Kyobu Geka 2012 Jul;65(8):720-3
    Department of Thoracic Surgery, Okayama University Hospital, Japan.
    Patients with perioperative endocrine dysfunction represent a particular challenge to general thoracic surgeons. This article focuses on the 3 most commonly experienced endocrine disorders:diabetes mellitus, thyroid deficiency( hyper- and hypothyroidism), and long-term steroid administration. The point is to control those endocrine disorders as best as possible before surgery to avoid severe perioperative complications. Read More

    Ogilvie's syndrome in a case of myxedema coma.
    Indian J Endocrinol Metab 2012 May;16(3):447-9
    Department of Internal Medicine, Armed Forces Medical College, Pune, India.
    Ogilvie's syndrome [acute colonic pseudo-obstruction (ACPO)] presents as massive colonic dilatation without a mechanical cause, usually in critically ill patients due to imbalanced sympathetic and parasympathetic activity. The initial therapy remains conservative with supportive measures (correction of metabolic, infectious or pharmacologic factors) followed by neostigmine and decompressive colonoscopy. Surgery is reserved for patients with clinical deterioration or with evidence of colonic ischemia or perforation. Read More

    Thyroid emergencies.
    Med Clin North Am 2012 Mar 17;96(2):385-403. Epub 2012 Feb 17.
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010-2910, USA.
    This review presents current knowledge about the thyroid emergencies known as myxedema coma and thyrotoxic storm. Understanding the pathogenesis of these conditions, appropriate recognition of the clinical signs and symptoms, and their prompt and accurate diagnosis and treatment are crucial in optimizing survival. Read More

    Chorea--an unusual manifestation in a woman recovering from myxedema coma.
    Endocr Pract 2012 May-Jun;18(3):e43-8
    Division of Endocrinology and Metabolism, Faculty of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Canada.
    Objective: To report a case of reversible chorea in a woman with myxedema coma.

    Methods: We describe the clinical course, imaging findings, and laboratory test results of a patient who initially presented with myxedema coma and then developed reversible chorea upon treatment.

    Results: A 33-year-old woman with a known history of primary hypothyroidism presented with a 3-week history of lethargy, progressing to a precipitous decline in consciousness that required intubation. Read More

    Severe hypothermia in myxoedema coma: a rewarming by extracorporeal circulation.
    Emerg Med Australas 2011 Dec;23(6):773-5
    Department of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Israel.
    Myxoedema coma is the most lethal manifestation of hypothyroidism. It represents a true medical emergency, especially in the case of cardiovascular instability. Extracorporeal circulation is usually used for rewarming and for providing cardiac support in patients with severe hypothermia and, in addition, cardiovascular instability. Read More

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