426 results match your criteria Hypothyroidism and Myxedema Coma


Pericardial Effusion as an Initial Presentation of Panhypopituitarism.

Eur J Case Rep Intern Med 2020 24;7(4):001478. Epub 2020 Feb 24.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Portugal.

Pericardial effusion has a broad spectrum of clinical presentation, ranging from an incidental finding on imaging to a potentially fatal emergency such as pericardial tamponade, the most severe presentation. The authors present a case of a middle-aged male hospitalized due to shortness of breath. Initial work-up was positive for massive pericardial effusion with haemodynamic compromise. Read More

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http://dx.doi.org/10.12890/2020_001478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162561PMC
February 2020

Anesthesia for Endocrine Emergencies.

Anesthesiol Clin 2020 Mar 2;38(1):149-163. Epub 2020 Jan 2.

Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2-AN, Seattle, WA 98101, USA; Division of Critical Care Medicine, Virginia Mason Medical Center, 1100 Ninth Avenue, B2-AN, Seattle, WA 98101, USA. Electronic address:

Although endocrine emergencies are not common occurrences, their identification and careful perioperative management are of paramount importance for reduction of patient morbidity and mortality. The most common critical endocrine abnormalities are associated with functional tumors, such as pheochromocytomas, insulinomas, and carcinoid tumors, leading to carcinoid syndrome, abnormal thyroid function, or disturbances in the hypothalamus-pituitary-adrenal axis, causing adrenal insufficiency. This article aims to discuss the pathophysiology, diagnosis, and perioperative management of pheochromocytomas, hyperthyroidism, hypothyroidism, adrenal insufficiency, carcinoid disease, and insulinomas. Read More

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http://dx.doi.org/10.1016/j.anclin.2019.10.006DOI Listing

Myxedema Coma in a Pediatric Patient with Down Syndrome.

J Pediatr Intensive Care 2020 Mar 24;9(1):70-73. Epub 2019 Oct 24.

Department of Pediatrics, Pediatric Intensive Care Unit, Seth G.S. Medical College & KEM Hospital, Mumbai, Maharashtra, India.

Myxedema coma due to severe/long standing hypothyroidism is a known fatal endocrine emergency but is rare in children and unreported in pediatric Down syndrome. It mimics other conditions in the emergency room, making the diagnosis challenging. We present a 10-year-old-male child with global developmental delay and Down syndrome phenotype, admitted for altered sensorium subsequent to a febrile illness. Read More

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http://dx.doi.org/10.1055/s-0039-1698812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978172PMC

Diagnosis and treatment of hypothyroidism in old people : A new old challenge.

Wien Klin Wochenschr 2020 Mar 26;132(5-6):161-167. Epub 2019 Nov 26.

Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via S. Sofia,78, 95123, Catania, Italy.

Purpose: To review the diagnosis and the treatment of both subclinical and overt hypothyroidism in old people, which could represent a challenge for the clinicians.

Methods: Narrative literature review. An extensive literature search was performed using the databases of Scopus, Medline through PubMed, and Google Scholar from January 1975 to May 2019. Read More

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http://dx.doi.org/10.1007/s00508-019-01579-8DOI Listing

Myxedema coma: four patients diagnosed at the Internal Medicine Department of the Dr. Negrin University Hospital in Spain.

Pan Afr Med J 2019 3;34. Epub 2019 Sep 3.

Servicio de Medicina Interna, Hospital Universitario de Gran Canaria Dr Negrin, Spain.

Myxedema coma is a rare complication of hypothyroidism. Clinical examination may reveal hypotension, bradycardia, and hypothermia. Laboratory tests may show hyponatremia, lipid disorders, and elevations of creatine kinase, liver, and cardiac enzymes. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.7.19164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850735PMC
December 2019
5 Reads

Myxedema coma accompanied by sick sinus syndrome and hypoventilation: A case report.

J Gen Fam Med 2019 Sep 25;20(5):206-208. Epub 2019 Jun 25.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kitaku Japan.

Myxedema coma is an emergency presentation of hypothyroidism, and cardiopulmonary manifestations of the disease are related to a high mortality rate. We herein report a case of myxedema coma accompanied by sick sinus syndrome requiring temporary cardiac pacing and hypercapnic respiratory failure in an 87-year-old woman. This case is unique because both of the cardiac and pulmonary manifestations were reversible and successfully treated with thyroid hormone replacement. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jgf2.267
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http://dx.doi.org/10.1002/jgf2.267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732564PMC
September 2019
4 Reads

Myxedema Coma Complicated by Pancytopenia.

Case Rep Med 2019 14;2019:2320751. Epub 2019 Jul 14.

Kings County Hospital Center, Department of Pulmonary and Critical Care, Brooklyn, NY, USA.

Hypothyroidism is common, with an extreme manifestation of myxedema coma if untreated. Hematologic consequences of myxedema coma include mild leukopenia and anemia, rarely pancytopenia. We present a patient with typical symptoms of myxedema coma, but found to be pancytopenic, with sustained response to levothyroxine and blood transfusion for anemia. Read More

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https://www.hindawi.com/journals/crim/2019/2320751/
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http://dx.doi.org/10.1155/2019/2320751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664498PMC
July 2019
3 Reads

Thyroid emergencies.

Pol Arch Intern Med 2019 08 25;129(7-8):526-534. Epub 2019 Jun 25.

Endocrinology Division, Department of Medicine, Georgetown University School of Medicine, Washington DC, United States

Myxedema coma and thyroid storm are among the most common endocrine emergencies presenting to general hospitals. Myxedema coma represents the most extreme, life‑threatening expression of severe hypothyroidism, with patients showing deteriorating mental status, hypothermia, and multiple organ system abnormalities. It typically appears in patients with preexisting hypothyroidism via a common pathway of respiratory decompensation with carbon dioxide narcosis leading to coma. Read More

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http://dx.doi.org/10.20452/pamw.14876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721612PMC
August 2019
10 Reads

Untreated primary hypothyroidism with simultaneous rhabdomyolysis, pericardial effusion, and sudden sensorineural hearing loss: a case report.

BMC Endocr Disord 2019 May 22;19(1):52. Epub 2019 May 22.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Hypothyroidism, one of the prevalent endocrine disorders worldwide, has a broad spectrum of clinical manifestations, from an asymptomatic condition to myxedema coma. Although the majority of patients with hypothyroidism have minor clinical symptoms, which are recovered with levothyroxine treatment, some patients occasionally do experience fatal complications. Here we report, for the first time, the case of a patient who had hypothyroidism with simultaneous occurrence of rhabdomyolysis with acute kidney injury, moderate pericardial effusion, and sudden sensorineural hearing loss. Read More

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http://dx.doi.org/10.1186/s12902-019-0379-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530099PMC
May 2019
9 Reads

Myxoedema coma following commencement of anti-TNF therapy and tuberculosis prophylaxis in a patient with RA and latent tuberculosis infection.

Postgrad Med J 2019 May 13;95(1123):281. Epub 2019 May 13.

Department of Neurology, Fortis Memorial Research Institute, Gurugram, India.

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http://dx.doi.org/10.1136/postgradmedj-2019-136458DOI Listing
May 2019
1 Read
1.549 Impact Factor

Hypothyroidism as a Predictor of Surgical Outcomes in the Elderly.

Front Endocrinol (Lausanne) 2019 24;10:258. Epub 2019 Apr 24.

Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy.

There is a high prevalence of hypothyroidism in the elderly population, mainly among women. The most important cause is autoimmune thyroiditis, but also iodine deficiency, radioiodine ablation, and surgery may be responsible for hypothyroidism in elderly hospitalized patients. Thyroid-related symptoms are sometimes comparable to physiological manifestations of the aging process, and hypothyroidism may be related with many symptoms which can be present in critical patients, such as cognitive impairment, cardiovascular, gastrointestinal, and hematological alterations, and eventually myxedema coma which is a severe and life-threatening condition in older adults. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00258
Publisher Site
http://dx.doi.org/10.3389/fendo.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491643PMC
April 2019
18 Reads

Mechanical Circulatory Support in Management of Cardiogenic Shock and Myxedema Coma.

Case Rep Cardiol 2019 6;2019:2595736. Epub 2019 Mar 6.

Division of Cardiovascular Medicine, St. John Providence Ascension Health System, Warren, MI, USA.

The cardiovascular system is a major target of thyroid hormone action and the two systems are closely interlinked. It can be greatly impacted even with subtle alterations in thyroid function. Caution is needed when implementing thyroid hormone replacement in patients with severe hypothyroidism, especially in the setting of ischemic coronary artery disease. Read More

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https://www.hindawi.com/journals/cric/2019/2595736/
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http://dx.doi.org/10.1155/2019/2595736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431388PMC
March 2019
27 Reads

Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine.

Endocr J 2019 May 8;66(5):469-474. Epub 2019 Mar 8.

Division of Endocrinology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya 453-8511, Japan.

Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate. It is characterized by the deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. Early disease diagnosis and advancements in intensive supportive care have reduced the mortality rate. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
Publisher Site
http://dx.doi.org/10.1507/endocrj.EJ18-0469DOI Listing
May 2019
10 Reads

Myxedema coma precipitated by diabetic ketoacidosis after total thyroidectomy: a case report.

J Med Case Rep 2019 Mar 4;13(1):50. Epub 2019 Mar 4.

Division of Trauma and Surgical Critical Care, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 137-701, Korea.

Background: Myxedema coma is profound decompensated hypothyroidism usually precipitated by stressors, and its occurrence in association with total thyroidectomy or metabolic disorders, such as diabetic ketoacidosis, is unusual.

Case Presentation: A 43-year-old Asian man with history of total thyroidectomy who was scheduled for a second radioactive iodine therapy presented to our hospital with decreased mental status and hyperglycemia. He had a history of thyroid cancer but did not have diabetes mellitus. Read More

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http://dx.doi.org/10.1186/s13256-019-1992-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398221PMC
March 2019
33 Reads

Myxoedema coma in a 2-year-old girl with untreated congenital hypothyroidism: Case report and literature review.

J Paediatr Child Health 2019 Jun 12;55(6):707-710. Epub 2018 Dec 12.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1111/jpc.14339DOI Listing
June 2019
5 Reads

Postoperative myxedema coma in patients undergoing major surgery: Case series.

Auris Nasus Larynx 2019 Aug 16;46(4):605-608. Epub 2018 Nov 16.

Department of Otolaryngology, Head & Neck and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Myxedema coma is a serious complication of hypothyroidism that can be precipitated by major surgery. It is extremely rare, with only a few reports in the literature. This study aims to present a relatively large case series of post-surgical myxedema coma and to analyze medical and surgical risk factors. Read More

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http://dx.doi.org/10.1016/j.anl.2018.10.019DOI Listing
August 2019
43 Reads

Misleading symptoms and successful noninvasive rewarming of a patient with severe hypothermia (23.1 °C).

Anaesthesist 2018 12 30;67(12):931-935. Epub 2018 Oct 30.

Department of Anesthesiology, Ludwig Maximilian University Hospital, Marchioninistr. 15, 81377, Munich, Germany.

Accidental severe hypothermia is a medical emergency in which symptoms may include coma, apnea, pulmonary edema, ventricular dysrhythmia or asystole. Despite optimal treatment, mortality remains high. This article reports a case of severe hypothermia in a geriatric hypothyroid patient, where despite a body core temperature of 23. Read More

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http://dx.doi.org/10.1007/s00101-018-0508-4DOI Listing
December 2018
11 Reads

Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature.

Curr Hypertens Rev 2019 ;15(1):13-16

Division of Cardiovascular Medicine, University of Southern California, Los Angeles-90033, LA, United States.

Background: Myxedema heart disease is an extremely rare disease entity and should be suspected in patients with unexplained heart failure refractory to conventional treatment. Myxedema coma with co- existent heart disease is not well known and very few cases have been reported.

Conclusion: Here, we present an interesting case of myxedema coma with severe valvular cardiomyopathy followed by a concise review of the literature with special emphasis on epidemiology, pathophysiology, diagnosis and therapeutic modalities. Read More

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http://dx.doi.org/10.2174/1573402114666181001121108DOI Listing
August 2019
5 Reads

Critical Consideration of Myxedema Coma in the Postoperative Setting: A Case Report.

A A Pract 2019 Feb;12(4):119-121

Department of Anesthesiology, Division of Critical Care, University of California San Diego, San Diego, California.

Myxedema coma is a rare but highly fatal condition with reported mortality >40%-50%. Early recognition and prompt treatment are critical for survival. Here we describe a case of possible postoperative myxedema coma after subacute neck hematoma evacuation after hemithyroidectomy in a patient on concurrent amiodarone therapy. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000864DOI Listing
February 2019
47 Reads

Comatose patient with hypothermia, dyspnea, and general edema in the emergency department: a case report.

J Int Med Res 2018 Oct 15;46(10):4338-4342. Epub 2018 Aug 15.

1 Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.

Patients presenting to the emergency department with hypothermia are rare and often require prompt diagnosis and management. Myxedema coma, which may cause severe hypothermia, is a true endocrine emergency requiring early and appropriate treatment. We report on a 47-year-old woman with a history of hyperthyroidism who underwent thyroidectomy 5 years previously, with no regular medication or examinations. Read More

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http://dx.doi.org/10.1177/0300060518791074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166344PMC
October 2018
35 Reads

Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis.

Intern Med 2018 Nov 6;57(21):3117-3122. Epub 2018 Jun 6.

Diabetes Center, Ebina General Hospital, Japan.

Gonadotropin-releasing hormone (GnRH) agonists have been used for the treatment of various diseases. Although autoimmune thyroid disease has been reported as a rare complication of these agents, the symptoms are almost always transient and non-life-threatening. We herein report a rare case of an 83-year-old man receiving GnRH agonist treatment for prostate cancer who developed myxedema coma complicated by acute pancreatitis. Read More

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http://dx.doi.org/10.2169/internalmedicine.0639-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262710PMC
November 2018
51 Reads

Effects of Long-Term Combination LT4 and LT3 Therapy for Improving Hypothyroidism and Overall Quality of Life.

South Med J 2018 06;111(6):363-369

From the Departments of Internal Medicine, Research and Biostatistical Analysis, and Endocrinology, UPMC Pinnacle Health, Harrisburg, Pennsylvania.

Objectives: Hypothyroidism results in decreased mood and neurocognition, weight gain, fatigue, and many other undesirable symptoms. The American Association of Clinical Endocrinologists, the American Thyroid Association (ATA), and The Endocrine Society recommend levothyroxine (LT4) monotherapy as the treatment for hypothyroidism; however, after years of monotherapy, some patients continue to experience impaired quality of life. Combination LT4 and synthetic liothyronine (LT3) therapy or the use of desiccated thyroid extract (DTE), has not been suggested for this indication based on short-duration studies with no significant benefits. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965938PMC
June 2018
55 Reads
1.120 Impact Factor

Amiodarone induced myxedema coma: Two case reports and literature review.

Heart Lung 2018 Jul - Aug;47(4):429-431. Epub 2018 May 21.

Department of Cardiology, New York Medical College, St. Joseph Medical Center, 703 Main Street, Paterson, NJ 07503, USA.

Amiodarone is a benzofuran derivative that contains 37% iodine by weight and is structurally similar to the thyroid hormones. Amiodarone has a complex effect on the thyroid gland, ranging from abnormalities of thyroid function tests to overt thyroid dysfunction, with either thyrotoxicosis or hypothyroidism. Myxedema coma secondary to amiodarone use has been rarely reported in the literature. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2018.03.012DOI Listing
February 2019
34 Reads

Myxedema Coma due to Hashimoto Thyroiditis: A Rare but Real Presentation of Failure to Thrive in Infancy.

Horm Res Paediatr 2018 4;90(5):332-336. Epub 2018 May 4.

Background: Hashimoto thyroiditis (HT) is uncommon in infancy, and myxedema coma (MC) is even less common. While prior reports have documented these entities separately, to our knowledge, MC in combination with HT has not been reported before in this age group.

Methods/results: A 10-month-old female presented with ptosis, lethargy, dysphagia, and failure to thrive (FTT). Read More

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http://dx.doi.org/10.1159/000488467DOI Listing
July 2019
64 Reads

[Thyroid Storm and Myxedema Coma].

Dtsch Med Wochenschr 2018 Mar 15;143(6):397-405. Epub 2018 Mar 15.

Thyroid storm and myxedema coma are the most severe clinical forms of thyroid dysfunction. While both hyper- and hypothyroidsm are common diseases, thyroid storm and myxedema coma are rare. Due to their unspecific signs and symptoms they are often difficult to diagnose. Read More

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http://dx.doi.org/10.1055/s-0043-111728DOI Listing
March 2018
16 Reads

Myxedema Coma.

Authors:
Atif Munir

J Ayub Med Coll Abbottabad 2018 Jan-Mar;30(1):119-120

Diabetes and Endocrinology, University Hospital of Hartlepool, UK.

Myxedema may be the first presentation of patients with undiagnosed hypothyroidism. Definitive management is with thyroid hormone but supportive measures, identification and treatment of precipitating factors in an appropriately safe environment are vital. There is no consensus about preferred thyroid hormone regimen. Read More

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August 2018
14 Reads

Dementia, cardiomyopathy and pseudo-obstruction in a 63-year-old female.

Authors:
A Garrahy A Agha

Eur J Intern Med 2018 09 2;55:e5-e6. Epub 2018 Mar 2.

Department of Endocrinology, Beaumont Hospital and RCSI Medical School, Beaumont, Dublin 9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2018.02.028DOI Listing
September 2018
12 Reads

Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation.

Surg Neurol Int 2018 8;9:25. Epub 2018 Feb 8.

Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.

Background: Altered mental status describes impaired mental functioning ranging from confusion to coma and indicates an illness, either metabolic or structural in nature. Metabolic causes include hypothyroidism, hyperuremia, hypo/hyperglycemia, hypo/hypernatremia, and encephalopathy. The structural causes include tumors, brain hemorrhage, infection, and stroke. Read More

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http://surgicalneurologyint.com/surgicalint-articles/managem
Publisher Site
http://dx.doi.org/10.4103/sni.sni_357_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820833PMC
February 2018
53 Reads

Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia.

Psychiatry Clin Neurosci 2018 02 23;72(2):131. Epub 2017 Dec 23.

Department of Psychiatry, Otaru General Hospital, Hokkaido, Japan.

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http://dx.doi.org/10.1111/pcn.12626DOI Listing
February 2018
18 Reads

Sudden cardiac arrest as a rare presentation of myxedema coma: case report.

J Community Hosp Intern Med Perspect 2017 18;7(5):318-320. Epub 2017 Oct 18.

Department of Pulmonary Medicine, Interfaith Medical Centre, Brooklyn, NY, USA.

Myxedema coma is a decompensated hypothyroidism which occurs due to long-standing, undiagnosed, or untreated hypothyroidism. Untreated hypothyroidism is known to affect almost all organs including the heart. It is associated with a decrease in cardiac output, stroke volume due to decreased myocardial contractility, and an increase in systemic vascular resistance. Read More

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http://dx.doi.org/10.1080/20009666.2017.1374110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676798PMC
October 2017
20 Reads

Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies.

Intern Med 2018 Jan 1;57(2):265-268. Epub 2017 Nov 1.

Department of Neurology, Obihiro Kosei General Hospital, Japan.

We herein report the case of myasthenic crisis occurring in a 51-year-old man. He had experienced ptosis, increased body weight with edema, and fatigue with dyspnea. He presented at our emergency department with disturbed consciousness. Read More

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http://dx.doi.org/10.2169/internalmedicine.9291-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820048PMC
January 2018
11 Reads

Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma.

Clin Case Rep 2017 10 8;5(10):1706-1711. Epub 2017 Sep 8.

Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand.

High-dose intravenous thyroxine (T4) is the preferable treatment for myxedema coma. We describe the clinical course of a 69-year-old man who presented with myxedema coma and received oral levothyroxine (LT4) therapy (1 mg) in a split dose. This suggests split high-dose oral LT4 as a therapeutic option in myxedema coma. Read More

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http://dx.doi.org/10.1002/ccr3.1131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628197PMC
October 2017
13 Reads

Challenges in the Management of a Patient with Myxoedema Coma in Ghana: A Case Report.

Ghana Med J 2017 Mar;51(1):39-42

Neurology Unit, Department of Medicine and Therapeutics, School of Medicine and Dentistry, University of Ghana, PO Box GP 4236, Accra, Ghana.

Myxoedema coma is a rare life-threatening disease, and it is essential that it is managed appropriately to reduce the associated high mortality. However, in the setting where efficient healthcare delivery is hampered by inadequacies, the management of such cases may pose a significant challenge. We present the case of a middle-aged woman diagnosed with myxoedema coma and severe hyponatremia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611947PMC
http://dx.doi.org/10.4314/gmj.v51i1.8DOI Listing
March 2017
18 Reads

[Thyroid emergencies : Thyroid storm and myxedema coma].

Internist (Berl) 2017 Oct;58(10):1011-1019

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland.

Thyroid emergencies are rare life-threatening endocrine conditions resulting from either decompensated thyrotoxicosis (thyroid storm) or severe thyroid hormone deficiency (myxedema coma). Both conditions develop out of a long-standing undiagnosed or untreated hyper- or hypothyroidism, respectively, precipitated by an acute stress-associated event, such as infection, trauma, or surgery. Cardinal features of thyroid storm are myasthenia, cardiovascular symptoms, in particular tachycardia, as well as hyperthermia and central nervous system dysfunction. Read More

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http://dx.doi.org/10.1007/s00108-017-0306-0DOI Listing
October 2017
55 Reads

[Myxedema coma].

Medicina (B Aires) 2017 ;77(4):321-328

Department of Medicine, Washington Hospital Center, Washington, DC, USA.

Hypothyroidism is a frequently diagnosed and simply treated disease. If not recognised, however, in time it may develop into the most severe manifestation of hypothyroidism known as myxedema coma. The term "myxedema coma" is generally seen as misleading since most patients do not initially present in a coma. Read More

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July 2018
62 Reads

Thyroid Emergencies: New Insight into Old Problems.

J Assoc Physicians India 2017 Aug;65(8):68-76

Senior Resident, Dept. of Medicine, LHMC and Associated Hospitals, New Delhi.

Thyroid emergencies are major life-threatening endocrine conditions associated with life-threatening disorders resulting from either severe deficiency or excess of thyroid hormones. Deficiency of thyroid hormones may present as myxedema coma whereas excessive hormone production can present as life threatening thyrotoxic storm. The diagnosis of both requires a high index of clinical suspicion. Read More

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August 2017
49 Reads

Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion.

Proc (Bayl Univ Med Cent) 2017 Jul;30(3):295-297

Departments of Internal Medicine (Werlang) and Critical Care Medicine (Pimentel, Diaz-Gomez), Mayo Clinic, Jacksonville, Florida. Dr. Pimentel is currently at Irmandade Santa Casa de Misericordia, Porto Alegre, Brazil.

A large pleural effusion causing cardiac tamponade physiology and severe hemodynamic compromise is an uncommon event. We report a case of a 53-year-old woman with severe hypothyroidism presenting with myxedema coma and refractory shock. Her hemodynamic status failed to respond to fluid resuscitation and vasopressors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468018PMC
http://dx.doi.org/10.1080/08998280.2017.11929620DOI Listing
July 2017
14 Reads

Myxedema coma: A case report of pediatric emergency care.

Medicine (Baltimore) 2017 May;96(21):e6952

aPediatric Critical Care Medicine, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine bDepartment of Pediatric Endocrinology/Genetics, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai, China.

Raionale: Myxedema coma (MC) is extremely rare but lethal in pediatric patients with hypothyroidism leading to altered mental status and hypothermia. But there is no clinical guideline for such cases.

Patient Concerns: A 6-year-old Chinese girl presented with coma and hypothermia preceded by pneumonia. Read More

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http://dx.doi.org/10.1097/MD.0000000000006952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457868PMC
May 2017
38 Reads

Diagnosis of myxedema coma complicated by renal failure: a case report.

Clin Case Rep 2017 04 21;5(4):399-402. Epub 2017 Feb 21.

Department of General Medicine Himi Municipal Hospital Kanazawa Medical University 31-9 Saiwai-cho Himi Toyama Japan.

Myxedema coma, caused by severe lack of thyroid hormone, is characterized by deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. We describe an 84-year-old woman who presented with renal failure and new onset severe hypothyroidism leading to challenges in the recognition of myxedema coma. Read More

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http://dx.doi.org/10.1002/ccr3.850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378864PMC
April 2017
22 Reads

Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan.

J Epidemiol 2017 Mar 5;27(3):117-122. Epub 2017 Jan 5.

Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.

Background: Myxedema coma is a life-threatening and emergency presentation of hypothyroidism. However, the clinical features and outcomes of this condition have been poorly defined because of its rarity.

Methods: We conducted a retrospective observational study of patients diagnosed with myxedema coma from July 2010 through March 2013 using a national inpatient database in Japan. Read More

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http://dx.doi.org/10.1016/j.je.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350620PMC
March 2017
28 Reads

Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis.

J Am Osteopath Assoc 2017 Jan;117(1):50-54

Myxedema psychosis is uncommon in patients with primary hypothyroidism. Most often, this disease state can be found in patients with Hashimoto thyroiditis or after total thyroidectomy. Chronic hypothyroidism can lead to an insidious onset of psychiatric symptoms in patients, such as dementia, delirium, psychosis, hallucinations, and coma. Read More

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http://dx.doi.org/10.7556/jaoa.2017.007DOI Listing
January 2017
25 Reads

An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure.

Case Rep Crit Care 2016 30;2016:3438080. Epub 2016 Oct 30.

Pulmonary and Critical Care, St. John's Riverside Hospital, 967 N. Broadway, Yonkers, NY 10701, USA.

Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Read More

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http://dx.doi.org/10.1155/2016/3438080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107213PMC
October 2016
14 Reads

Impending myxedema coma as the initial presentation of lung cancer.

J Formos Med Assoc 2017 06 4;116(6):488-489. Epub 2016 Nov 4.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.09.009DOI Listing
June 2017
11 Reads
1.700 Impact Factor

Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics.

Horm Res Paediatr 2017 16;87(5):350-353. Epub 2016 Sep 16.

Section of Endocrinology, Metabolism and Diabetes, Nationwide Children's Hospital, Columbus, Ohio, USA.

Background: Myxedema coma (MC), a medical emergency defined as severe hypothyroidism leading to altered mental status, is more common in older women with hypothyroidism.

Methods/results: A 7-year-old Caucasian male with chromosome 1q deletion presented with altered mental status preceded by milestone regression. His presenting labs results were: thyroid-stimulating hormone (TSH) 0. Read More

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http://dx.doi.org/10.1159/000449223DOI Listing
March 2018
19 Reads

Thyroid Emergencies.

Authors:
Angela M Leung

J Infus Nurs 2016 Sep-Oct;39(5):281-6

Division of Endocrinology, David Geffen School of Medicine at UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California. Angela M. Leung, MD, MSc, is an assistant clinical professor of medicine in the Division of Endocrinology at the David Geffen School of Medicine at the University of California, Los Angeles, and the VA Greater Los Angeles Healthcare System, both in Los Angeles, California.

Myxedema coma and thyroid storm are thyroid emergencies associated with increased mortality. Prompt recognition of these states-which represent the severe, life-threatening conditions of extremely reduced or elevated circulating thyroid hormone concentrations, respectively-is necessary to initiate treatment. Management of myxedema coma and thyroid storm requires both medical and supportive therapies and should be treated in an intensive care unit setting. Read More

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http://dx.doi.org/10.1097/NAN.0000000000000186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657262PMC
June 2017
46 Reads

Myxoedema coma: a forgotten presentation of extreme hypothyroidism.

BMJ Case Rep 2016 Jun 28;2016. Epub 2016 Jun 28.

The Reading Hospital and Medical Center, West Reading, Pennsylvania, USA.

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http://dx.doi.org/10.1136/bcr-2016-216225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932398PMC
June 2016
13 Reads

Pediatric Patient With Altered Mental Status and Hypoxemia: Case Report.

Pediatr Emerg Care 2017 Jul;33(7):486-488

From the *Department of Pediatrics, University of Pittsburgh School of Medicine; †Department of Pediatrics, Children's Hospital of Pittsburgh; ‡Division of Pediatric Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine; and §Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Childhood cases of myxedema coma are extremely rare. We report a case of a 5-year-old girl transferred to a tertiary care pediatric emergency department with hypoxemia and altered mental status and diagnosed with severe hypothyroidism and myxedema coma in the setting of acute influenza infection. Although it is rare, myxedema coma must remain in the differential diagnosis for altered mental status and organ dysfunction in the pediatric population. Read More

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http://dx.doi.org/10.1097/PEC.0000000000000722DOI Listing
July 2017
23 Reads

A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy.

Endocr J 2016 Jun 26;63(6):523-32. Epub 2016 Mar 26.

Department of General Medicine, National Defense Medical College, Tokorozawa, Japan.

Myxedema coma (MC) is a life-threatening endocrine crisis caused by severe hypothyroidism. However, validated diagnostic criteria and treatment guidelines for MC have not been established owing to its rarity. Therefore, a valid animal model is required to investigate the pathologic and therapeutic aspects of MC. Read More

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http://dx.doi.org/10.1507/endocrj.EJ16-0005DOI Listing
June 2016
15 Reads