43,001 results match your criteria Hypothyroidism and Myxedema Coma
Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.
The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More
Biomed Res Int 2018 14;2018:2032413. Epub 2018 Nov 14.
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. Read More
Case Rep Endocrinol 2018 12;2018:4369531. Epub 2018 Nov 12.
Department of Endocrinology, La Rabta hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
Thyroid involvement with tuberculosis is an uncommon condition even in endemic countries. As its clinical presentation is not specific, diagnosis is often difficult and requires histopathological confirmation. Herein we report an observation of secondary tuberculosis of the thyroid gland in a woman with a type 2 diabetes mellitus and a primary hypothyroidism. Read More
Int J Endocrinol 2018 14;2018:1871530. Epub 2018 Nov 14.
Department of endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Purpose: To determine if the TSH is related to estimated glomerular filtration rate (eGFR) in T2D patients without overt thyroid dysfunction.
Methods: A cohort study of 5936 T2D patients was assessed for thyroid and kidney functions, in whom 248 with subclinical hyperthyroidism and 362 with subclinical hypothyroidism. Serum creatinine and 24-hour urine albumin excretion (UAE) were collected. Read More
Pediatr Hematol Oncol 2018 Dec 11:1-10. Epub 2018 Dec 11.
b Texas Children's Cancer and Hematology Centers , Houston , Texas , USA.
Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT. Read More
J Cardiol Cases 2010 Dec 6;2(3):e147-e150. Epub 2010 Jul 6.
National Cardiovascular Center, Osaka, Japan.
We encountered a case of hypothyroidism showing Brugada-type electrocardiogram (ECG). A 52-year-old man was referred to our hospital in August 2009. Past medical history showed that liver dysfunction and face edema of unknown origin had been pointed out 1 year earlier. Read More
Front Nutr 2018 23;5:110. Epub 2018 Nov 23.
Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy.
Although Scientific Societies have stated that there are very few indications for the use of soy-based formula (SF) in infant nutrition, their utilization rates have been repeatedly found to be higher than expected. It is likely that a significant role in this regard is played by the belief that the use of SF during infancy can reduce the risk of the development of several diseases later in life. Although no definitive data that can substantiate these claims have been collected, many people perceive soy consumption to confer significant health benefits and might also use soy for infant nutrition. Read More
Int J Endocrinol 2018 4;2018:8387530. Epub 2018 Nov 4.
Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.
Introduction: A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT).
Objective: The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT.
Materials And Methods: Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Read More
Front Endocrinol (Lausanne) 2018 23;9:699. Epub 2018 Nov 23.
Department of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.
A significant number of patients show sub-optimal adherence to levothyroxine (LT4) therapy, mainly because they have to postpone their breakfast by at least 30 min. The aim of this observational cross-sectional study was to assess the therapeutic compliance of patients on LT4 treatment and to verify the preference of a lifetime treatment in tablet or liquid form. Ambulatory care patients aged 18 years or older, affected by hypothyroidism and on LT4 treatment (in tablet or liquid form) were administered the eight-item Morisky Medication Adherence Scale (MMAS-8). Read More
J Thorac Oncol 2018 Dec 4. Epub 2018 Dec 4.
South Texas Accelerated Research Therapeutics, 4383 Medical Dr, San Antonio, TX 78229, USA.
Introduction: Anti-EGFR agents are standard treatments for patients with EGFR-mutant advanced NSCLC. The feasibility of combining erlotinib or gefitinib with anti-PD1 immunotherapy pembrolizumab was evaluated in the phase 1/2 KEYNOTE-021 (NCT02039674) study.
Methods: Adults with previously untreated stage IIIB/IV EGFR-mutant NSCLC were treated with pembrolizumab 2 mg/kg IV every 3 weeks plus oral erlotinib 150 mg daily in cohort E or oral gefitinib 250 mg daily in cohort F, using a 3+3 design with cohort expansion. Read More
J Pediatr 2018 Oct 24. Epub 2018 Oct 24.
Department of Paediatric Endocrinology, Children's University Hospital, Dublin, Ireland; Department of Paediatrics, School of Medicine, University College Dublin, Dublin, Ireland.
Objectives: To evaluate the timing of a delayed rise in thyroid-stimulating hormone (TSH) levels in preterm infants with congenital hypothyroidism, and to determine whether cases of congenital hypothyroidism would be missed by using current consensus guidelines of repeat screening at approximately 2 weeks of age or 2 weeks after the first screening.
Study Design: The study was performed over a 13-year period (January 2004-December 2016). Whole-blood TSH samples were collected between 72 and 120 hours after birth. Read More
J Am Acad Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:
Background: The association between psoriasis and thyroid diseases was unclear.
Objective: To examine the risk of thyroid diseases in psoriasis patients.
Methods: We used Taiwan's National Health Insurance Research Database to conduct a nationwide cohort study. Read More
BMC Pregnancy Childbirth 2018 Dec 3;18(1):468. Epub 2018 Dec 3.
Department of Endocrinology and Metabolism, The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning, 110001, People's Republic of China.
Background: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic.
Case Presentation: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. Read More
J Clin Aesthet Dermatol 2018 Oct 1;11(10):40-43. Epub 2018 Oct 1.
Drs. Platsidaki, Vasalou, Gerodimou, Markantoni, Kouris, Gregoriou, Rigopoulos, and Kontochristopoulos are with the Department of Dermatology and Venereology at Andreas Sygros Skin Hospital in Athens, Greece.
Skin tags (STs) are benign skin lesions. Their definite etiology remains unknown. We aim to examine the association of obesity, diabetes mellitus, hyperlipidemia, thyroid abnormalities, acanthosis nigricans, and multiple STs in a Greek primary population. Read More
Clin Chim Acta 2018 Nov 30. Epub 2018 Nov 30.
Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, People's Republic of China. Electronic address:
Background: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder. Although most patients present with isolated CH, some patients present with CH and extra-thyroidal congenital malformations (ECMs), for which less is known about the underlying genetics. The aim of this study was to investigate the genetic mechanisms in patients with CH and ECMs using chromosomal microarray (CMA) and whole exome sequencing (WES). Read More
Arch Biochem Biophys 2018 Nov 30;662:61-67. Epub 2018 Nov 30.
Dipartimento di Biologia, Università di Napoli Federico II, I-80126, Napoli, Italy.
We investigated the effects of thyroid state on the mechanisms underlying rat heart mitochondrial capacity to remove HO produced by an exogenous source. The removal rates were higher in the presence of respiratory substrates independently from thyroid state and were higher in hyperthyroid than in hypothyroid preparations. The thyroid state-linked changes in HO removal rates, mirrored those in HO release rates, showing that endogenous and exogenous HO do not compete for the removing system. Read More
Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.
O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.
Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.
Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More
J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.
Treatment of hypothyroidism involves the endogenous conversion of thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and may not be optimal in some cases when based on T4 alone. In the current issue of the JCI, Jo et al. present results that explain the reduced enzymatic activity of a common genetic variant of the enzyme responsible for this conversion, type 2 deiodinase (DIO2). Read More
J Paediatr Child Health 2018 Dec;54(12):1404-1405
Department of Endocrinology, S.C.B Medical College, Cuttack, India.
Rev Endocr Metab Disord 2018 Dec 3. Epub 2018 Dec 3.
Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Via Savi, 10, I-56126, Pisa, Italy.
Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Read More
Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.
Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More
Clin Diabetes Endocrinol 2018 28;4:20. Epub 2018 Nov 28.
1Nuclear Medicine/Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5028 USA.
Objective: To evaluate the success rate of therapeutic administration of a single calculated I activity for eliminating hyperthyroidism due to Graves' disease.
Methods And Materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated I activity of 0.2 mCi per estimated gram of thyroid tissue, adjusted for the 24-h RAIU. Read More
Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):88-96
Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More
Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):83-87
Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More
Thyroid 2018 Dec 1. Epub 2018 Dec 1.
School of Medicine, Cardiff University, IMEM , CEDS , C2 Link corridor , UHW , Cardiff, United Kingdom of Great Britain and Northern Ireland , CF14 4XN.
Background: Recent reports suggest that prescriptions for thyroid hormones have increased. We therefore analysed recent trends in and determinants of prevalence of treated hypothyroidism across the United Kingdom (UK).
Methods: UK-wide data held by the National Health Service and the Office of National Statistics were examined. Read More
Hand (N Y) 2018 Dec 2:1558944718813730. Epub 2018 Dec 2.
1 New York University, New York City, USA.
Background: Older patients are treated for fracture with increasing frequency. Although studies on animals suggest that older mice and rats heal fractures more slowly, the clinical implications remain unclear. A better understanding of differences in healing with age can help customize fracture treatment. Read More
J Clin Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.
Department of Endocrinology, Herlev-Gentofte University Hospital, Herlev, Denmark.
Context: Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF).
Objective: Examining the effects of L-T4 in patients with HF.
Design: Retrospective cohort study. Read More
Pediatr Med Chir 2018 Dec 5;40(2). Epub 2018 Dec 5.
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina.
Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs. Read More
Ecotoxicol Environ Saf 2018 Nov 30;170:25-32. Epub 2018 Nov 30.
School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Organophosphate flame retardants (OPFRs) have been widely used as alternatives to polybrominated diphenyl ethers for fire prevention. OPFRs are suspected of causing potential thyroid disruption in humans. In fish, their thyroid hormone modulation is reported but the mechanisms of this modulation are less understood. Read More
Endocrinol Metab (Seoul) 2018 Dec;33(4):466-472
Department of Endocrinology, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
Background: Thyroid dysfunction is associated with negative neonatal and obstetric outcomes. Large differences in thyroid function reference intervals exist across different populations. These differences can be explained by population-specific factors, such as iodine status. Read More
J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.
a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.
Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):836-839
Pediatrics Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
Objective: To carry out variant analysis for a Chinese boy featuring dyshormonogenesis due to congenital hypothyroidism.
Methods: DNA of the patient and his parents was extracted and sequenced by high-throughput sequencing. The results were validated with Sanger sequencing and analyzed with Bioinformatics software. Read More
J Pediatr Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.
Division of Neonatology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Altıntag, Ankara, Turkey.
Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Read More
Semergen 2018 Nov 30. Epub 2018 Nov 30.
University of Hail, Department of Biology, University of Hail, Hail, Saudi Arabia.
Background: Creatinine is the most widely used renal failure biomarker; however, it has a lot of drawbacks. One of the major drawbacks is the blind range (does not increase until 50% of the kidney deteriorates). On the other hand, cystatin C has gained more attention as a promising biomarker due to several advantages over creatinine. Read More
Lancet 2018 Nov 30. Epub 2018 Nov 30.
The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, National Institute of Health Research Biomedical Research Centre, London, UK.
Background: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. Read More
J Vet Intern Med 2018 Nov 30. Epub 2018 Nov 30.
Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Background: Thyroid hormone supplementation anecdotally has been described as a valid treatment option for dogs with aggression-related problems. However, prospective, controlled, and blinded trials evaluating behavior and neurohormonal status in hypothyroid dogs during treatment with levothyroxine are lacking.
Objective: Levothyroxine supplementation will have a significant influence on the behavior and neurohormonal status of dogs with spontaneous hypothyroidism. Read More
Rev Endocr Metab Disord 2018 Nov 29. Epub 2018 Nov 29.
Rheumatology Unit, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy.
The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic disorders, namely autoimmune thyroiditis, type 2 diabetes mellitus, and erectile/sexual dysfunctions. In this review, we summarize current knowledge on the endocrine/metabolic diseases associated with chronic HCV infection, focusing on the main concepts emerged in the recent literature in this field. Read More
J Neurosurg 2018 Nov 1:1-10. Epub 2018 Nov 1.
OBJECTIVELoss of pituitary function due to nonfunctional pituitary adenoma (NFPA) may be due to compression of the pituitary gland. It has been proposed that the size of the gland and relative perioperative gland expansion may relate to recovery of pituitary function, but the extent of this is unclear. This study aims to assess temporal changes in hormonal function after transsphenoidal resection of NFPA and the relationship between gland reexpansion and endocrine recovery. Read More
Horm Res Paediatr 2018 Nov 29:1-4. Epub 2018 Nov 29.
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Background: Variance between current American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and in clinical practice exists for the use of thyroid antibody and thyroid function screening in pediatric patients with new-onset type 1 diabetes (T1D).
Methods: North American Pediatric Endocrine Society (PES) members were surveyed regarding their thyroid screening practices of euthyroid youth with T1D. An institutional analysis of the ability of antithyroid peroxidase (aTPO) and antithyroglobulin antibodies (aTG) to predict the subsequent use of levothyroxine was performed. Read More
Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.
Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:
Purpose: Developing a quantitative decision-support strategy estimating the impact of normal tissue complications from definitive radiation therapy (RT) for head and neck cancer (HNC). We developed this strategy to identify oropharyngeal HNC patients that may benefit most from receiving proton RT.
Methods And Materials: Recent normal tissue complication probability (NTCP) models for dysphagia, esophagitis, hypothyroidism, xerostomia and oral mucositis were used to estimate NTCP for 33 oropharyngeal HNC patients previously treated with photon IMRT. Read More
Cochrane Database Syst Rev 2018 11 29;11:CD003819. Epub 2018 Nov 29.
Researcher in Systematic Reviews, Georg-Kerschensteiner-Straße 16, Munich, Germany, 81829.
Background: Iodine deficiency is the main cause of potentially preventable mental retardation in childhood, as well as causing goitre and hypothyroidism in people of all ages. It is still prevalent in large parts of the world.
Objectives: To assess the effects of iodine supplementation overall, and of different forms and dosages of iodine supplementation separately, in the prevention of iodine deficiency disorders in children. Read More
JAAPA 2018 Dec;31(12):43-44
Joshua Merson is an assistant professor in the PA program at MGH Institute of Health Professions and practices in the ED at Brigham and Women's Hospital, both in Boston, Mass. The author has disclosed no potential conflicts of interest, financial or otherwise.
Psychol Med 2018 Nov 29:1-10. Epub 2018 Nov 29.
Department of Epidemiology,Harvard T.H. Chan School of Public Health,Boston, MA,USA.
Background: Abnormal thyroid function is prevalent among women and has been linked to increased risk of chronic disease. Posttraumatic stress disorder (PTSD) has been linked to thyroid dysfunction in some studies; however, the results have been inconsistent. Thus, we evaluated trauma exposure and PTSD symptoms in relation to incident thyroid dysfunction in a large longitudinal cohort of civilian women. Read More
BMC Res Notes 2018 Nov 29;11(1):842. Epub 2018 Nov 29.
Faculty of Medicine, University of Khartoum, Qasr Street, P.O. Box 11111, Khartoum, Sudan.
Objective: This meta-analysis was done to estimate the prevalence of autoimmune thyroid diseases (ATDs) in Turner Syndrome patients, and to determine the clinical status of thyroid autoimmune diseases that occur frequently in association with Turner Syndrome.
Results: A total of 18 studies were included in the meta-analysis. The pooled overall prevalence of autoimmune thyroid diseases in Turner Syndrome patients was 38. Read More
Asia Pac J Clin Nutr 2018 ;27(6):1366-1373
Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health; Key Lab of Trace Elements and Human Health of Heilongjiang Province; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention; Harbin Medical University, Harbin, China.
Background And Objectives: When iodine intake is in excess, a susceptible population that has a genetic predisposition will have an increased risk of hypothyroidism or autoimmune thyroiditis. This study evaluated the vulnerability to iodine excess and subclinical thyroid disease through screening of single nucleotide polymorphisms (SNPs) in reproductive-age women to provide evidence to be used for the prevention of subclinical thyroid disease.
Methods And Study Design: In Shanxi province, four areas where a range of iodine exposures from low to high were chosen in each region, 60 women were anticipated to enrol, including 20 pregnant women, 20 lactating women, and 20 non-pregnant, non-lactating women. Read More
World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Neurosurgery, Children's Hospital of Wisconsin, Milwaukee, WI 53226. Electronic address:
Background: Hypothalamic hamartomas (HHs) are non-neoplastic congenital malformations associated with refractory epilepsy and behavioral disorders. Improvement in behavioral functioning following resection of HHs has been reported. Stereotactic laser ablation (SLA), a minimally invasive technique, has been used for the treatment of HH-related epilepsy. Read More
Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.
Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, California, USA.
In this case report, we present a novel mutation in Lim-homeodomain (LIM-HD) transcription factor, LHX3, manifesting as combined pituitary hormone deficiency (CPHD). This female patient was originally diagnosed in Egypt during infancy with Diamond Blackfan Anemia (DBA) requiring several blood transfusions. Around 10 months of age, she was diagnosed and treated for central hypothyroidism. Read More
Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.
Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.
The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years. Read More
Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.
Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.
Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More