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    1 OF 841

    Factors Associated With Health Care Utilization of Recurrent Clostridium difficile Infection in New York State.
    J Clin Gastroenterol 2018 Mar 21. Epub 2018 Mar 21.
    Gastroenterology and Hepatology.
    Background: The incidence of infection due to Clostridium difficile infection (CDI) and subsequent economic burden are substantial.

    Goals: The impact of changing practice patterns on demographics at risk and utilization of health care resources for recurrence of CDI remains unclear.

    Study: A total of 291,163 patients hospitalized for CDI were identified from 1995 to 2014 from the New York SPARCS database. Read More

    Global epidemiology of hyperthyroidism and hypothyroidism.
    Nat Rev Endocrinol 2018 Mar 23. Epub 2018 Mar 23.
    Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
    Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common conditions with potentially devastating health consequences that affect all populations worldwide. Iodine nutrition is a key determinant of thyroid disease risk; however, other factors, such as ageing, smoking status, genetic susceptibility, ethnicity, endocrine disruptors and the advent of novel therapeutics, including immune checkpoint inhibitors, also influence thyroid disease epidemiology. Read More

    Genetic basis for childhood interstitial lung disease among Japanese infants and children.
    Pediatr Res 2018 Feb 1;83(2):477-483. Epub 2017 Nov 1.
    Department of Obstetrics, Faculty of Medicine and Graduate School of Medicine, Hokkadio University, Sapporo, Japan.
    BackgroundGenetic variants responsible for childhood interstitial lung disease (chILD) have not been studied extensively in Japanese patients.MethodsThe study population consisted of 62 Japanese chILD patients. Twenty-one and four patients had pulmonary hypertension resistant to treatment (PH) and hypothyroidism, respectively. Read More

    First case report of sepsis caused byin Japan.
    JMM Case Rep 2018 Jan 10;5(1):e005135. Epub 2018 Jan 10.
    Department of Microbiology, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto, Chikusa-ku, Nagoya City, Aichi, 464-8650, Japan.
    Introduction: Species of the genusare opportunistic, usually saprophytic, glucose-non-fermenting, Gram-negative bacilli found in agricultural soil.infections are the least commoninfections and have low incidence.

    Case Presentation: Herein, we report the first case of sepsis within Japan in a 67-year-old Japanese woman with a history of hyperlipidaemia, hypertension, diabetes, hypothyroidism and osteoporosis. Read More

    Diffuse Myocardial Injuries are Present in Subclinical Hypothyroidism: A Clinical Study Using Myocardial T1-mapping Quantification.
    Sci Rep 2018 Mar 22;8(1):4999. Epub 2018 Mar 22.
    Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
    Subclinical hypothyroidism (SHT) is a common disorder that may represent early thyroid dysfunction and is related to adverse cardiovascular events. However, myocardial injuries induced by SHT are difficult to detect. Our previous study demonstrated that the cardiac magnetic resonance (CMR) myocardial longitudinal relaxation time (T1) mapping technique is a useful tool for assessing diffuse myocardial injuries in overt hypothyroidism patients. Read More

    Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study.
    BMJ Open 2018 03 22;8(3):e019003. Epub 2018 Mar 22.
    School of Public Health, University College Cork, Cork, Republic of Ireland.
    Objectives: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries.

    Design: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset.

    Participants: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands. Read More

    Rheumatoid arthritis in an adult patient with mosaic distal 18q-, 18p- and ring chromosome 18.
    F1000Res 2017 2;6:1940. Epub 2017 Nov 2.
    Department of Medicine, Montefiore Medical Center, Bronx, New York City, NY, USA.
    Ring chromosome 18 has a highly variable phenotype, depending on the extent of distal arm deletions. It is most commonly presented as a combination of 18p- and distal 18q- syndrome. IgA deficiency and autoimmune diseases have been previously described in these patients. Read More

    Sporadic hypothyroidism-related hypokalemic paralysis: Diagnosis in a resource-poor setting.
    J Family Med Prim Care 2017 Oct-Dec;6(4):862-864
    Department of Neurology, JIPMER, Puducherry, India.
    Hypothyroidism and distal renal tubular acidosis causing hypokalemic paralysis (HP) have been described only in four female patients. HP as the initial manifestation of uncomplicated diabetes has been reported only in three young males. We report two middle-aged patients presenting with gradual-onset areflexic quadriparesis and neck flop, associated with urinary potassium losses, and recovering over 3 days. Read More

    Nivolumab-induced synchronous occurrence of myositis and hypothyroidism in a patient with squamous cell lung cancer.
    Immunotherapy 2018 Mar;10(6):427-431
    Department for Lung Diseases 'Jordanovac', University Hospital Centre Zagreb, Jordanovac 104, 10000 Zagreb, Croatia.
    Aim: Alongside the proven efficacy, immunotherapy in treatment of malignant diseases can cause immune-related adverse events different from commonly known chemotherapy-related toxicities.

    Case Presentation: During nivolumab treatment of metastatic squamous cell lung cancer, the patient developed a symptomatic inflammatory myositis confirmed with muscle biopsy and primary hypothyroidism. After initiation of corticosteroids and thyroid hormone replacement, the clinical and laboratory improvement occurred. Read More

    Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Braz J Med Biol Res 2018 Mar 15;51(5):e7196. Epub 2018 Mar 15.
    Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
    Data on the association between subclinical thyroid dysfunction and coronary artery disease (CAD) is scarce. We aimed to analyze the association between thyroid function and CAD using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (0. Read More

    Initiation timing effect of levothyroxine treatment on subclinical hypothyroidism in pregnancy.
    Gynecol Endocrinol 2018 Mar 21:1-4. Epub 2018 Mar 21.
    a Department of Obstetrics and Gynecology , Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai , China.
    The aim of this study is to estimate the timing impact on levothyroxine replacement among pregnant women with subclinical hypothyroidism (SCH). Ninety-eight pregnant women diagnosed as SCH in the first trimester were randomly divided into three groups: Group A, instantly initiated levothyroxine after diagnosis; Group B, administrated treatment in the second trimester, and Group C, received no prescription. Incidence of pregnancy complications and pregnancy outcomes were compared among three groups and subgroup analysis were performed stratified with TPO status in Group B. Read More

    Amiodarone-Induced Thyroid Dysfunction: A Clinical Update.
    Exp Clin Endocrinol Diabetes 2018 Mar 20. Epub 2018 Mar 20.
    Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP.
    Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Read More

    Parenting styles and coping strategies among patients with early detected and treated congenital hypothyroidism.
    Arch Argent Pediatr 2018 Apr;116(2):142-145
    Hospital de Niños Ricardo Gutiérrez; Fundación de Endocrinología Infantil.
    Introduction: Congenital hypothyroidism (CH), as any chronic disease, has an impact on the parent-child relationship and on the child's resources to cope with conflicting situations.

    Objectives: To describe parenting styles according to the perception of children with CH and their coping strategies.

    Population And Methods: Children aged 9-10 years who had CH detected by newborn screening and had received adequate treatment and a group without CH (control group). Read More

    Immunological changes of T helper cells in flow cytometer-sorted CD4T cells from patients with Hashimoto's thyroiditis.
    Exp Ther Med 2018 Apr 1;15(4):3596-3602. Epub 2018 Feb 1.
    Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China.
    Recent incidence rates for Hashimoto's thyroiditis (HT) and hypothyroidism are higher than those of previous studies. Previous studies indicated that T helper cells may have a major role in the pathogenesis and development of HT, but there is no consensus in the literature. The aim of the present study was to explore the peripheral T helper cell response in the different stages of HT. Read More

    Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria.
    J Clin Res Pediatr Endocrinol 2018 Mar 19. Epub 2018 Mar 19.
    Mersin University Faculty of Medicine Department of Internal Medicine, Division of Endocrinology and Metabolism, Mersin, Turkey.
    Objective: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.

    Methods: Eighty newly diagnosed children were included into study. ESS was diagnosed in two different ways:Criteria 1; fT3 was below the lower limit, fT4 was within the normal or low limits, TSH was in normal range and in criteria 2 all the levels were same as criteria 1 but moreover rT3 was performed and was higher than normal limits. Read More

    Combination of Ipilimumab and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma.
    Front Oncol 2018 2;8:44. Epub 2018 Mar 2.
    Immunology Department, Moffitt Cancer Center, Tampa, FL, United States.
    Purpose: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic melanoma can be highly effective, but attrition due to progression before TIL administration (32% in prior institutional experience) remains a limitation. We hypothesized that combining ACT with cytotoxic T lymphocyte-associated antigen 4 blockade would decrease attrition and allow more patients to receive TIL.

    Experimental Design: Thirteen patients with metastatic melanoma were enrolled. Read More

    Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature.
    Case Rep Endocrinol 2018 10;2018:4135940. Epub 2018 Jan 10.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
    Aim: To present a case of Graves' disease complicated by methimazole induced agranulocytosis treated with therapeutic plasma exchange (TPE) and review of the literature.

    Case Presentation: A 21-year-old patient with a history of Graves' disease presented to the endocrine clinic. His history was significant for heat intolerance, weight loss, and tremors. Read More

    Heart failure, micronutrient profile, and its connection with thyroid dysfunction and nutritional status.
    Clin Nutr 2018 Mar 3. Epub 2018 Mar 3.
    Department of Internal Medicine, Medical School of Ribeirão Preto, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil.
    Introduction: Heart failure (HF) is a growing public health issue; its risk factors include inappropriate dietary intake of microelements such as iodine, selenium, zinc and iron, which may lead to thyroid dysfunction.

    Objective: This study aimed to assess the correlation among the functional class stages of patients with HF, iodine, selenium, iron and zinc levels with the presence of thyroid dysfunction.

    Methodology: One hundred nine patients from the HF outpatient clinic of the Clinics Hospital of Ribeirão Preto whose blood and urine were collected for micronutrient analysis and laboratory tests were selected. Read More

    Role of Virtual Touch Tissue Quantification in Hashimoto's Thyroiditis.
    Ultrasound Med Biol 2018 Mar 16. Epub 2018 Mar 16.
    Department of Ultrasound, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. Electronic address:
    We investigated the role of the virtual touch tissue quantification (VTQ) technique in diagnosing Hashimoto's thyroiditis (HT) and in distinguishing various HT-related thyroid dysfunctions. Two hundred HT patients and 100 healthy volunteers (the control group) were enrolled. The diagnostic performance of VTQ in predicting HT was calculated as the area under the receiver operating characteristic curve (A). Read More

    Thyrotropic hormones.
    Best Pract Res Clin Endocrinol Metab 2018 Jan 26;32(1):17-25. Epub 2017 Oct 26.
    Neonatal Unit, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:
    Thyroid hormones are crucial for normal cognition and neurodevelopment in children. The introduction of the screening programs for congenital hypothyroidism has decreased the incidence of untreated congenital hypothyroidism. As maternal thyroid disease is common, and may impact on thyroid gland development and function in the fetus, optimal management is crucial. Read More

    Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia.
    • Authors:
    Indian J Pediatr 2018 Mar 17. Epub 2018 Mar 17.
    Objective: The Task Force formed by ICMR aimed at studying the prevalence of congenital hypothyroidism and congenital adrenal hyperplasia, the template disorders included in all newborn screening programs, and to evaluate the unidentified challenges in its execution in health care services. It also intended to evaluate the feasibility of newborn screening with regards to different geo-ethnic regions from India.

    Methods: Five metropolitan centers identified had further 2 to 11 centers; both the urban and the rural sectors were included and were considered representative of the northern, southern, eastern, western and central parts of the country. Read More

    [Metabolic control and school performance in children with type 1 diabetes].
    Rev Chil Pediatr 2017 ;88(5):586-594
    Facultad de Medicina y Odontología, Universidad de Antofagasta, Chile.
    The impact of type 1 diabetes (T1D) on school performance is controversial.

    Objective: To study the relationship between school performance and metabolic control in children with T1D (Ch-T1D), comparing their school grades to general population children (Ch-GP).

    Patients And Method: Clinical data for 66 Ch-T1D was reviewed, school grades were compared in Ch-T1D with Glycated Haemoglobin (HbA1c) HbA1c < 7. Read More

    Endocr Pract 2018 Mar;24(3):265-272
    Objective: Patients with diabetic nephropathy (DMN) have an increased risk of cardiovascular disease (CVD). However, strategies to reduce this risk are limited. Thyroid hormone replacement therapy (THRT) in patients with hypothyroidism has been shown to reduce several surrogate markers of CVD. Read More

    Association of TSHR Gene Copy Number Variation with TSH Abnormalities.
    Biol Trace Elem Res 2018 Mar 15. Epub 2018 Mar 15.
    Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.
    Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. By consulting the literature, we found that the TSHR, PAX8, and PDE4B genes are associated with thyroid function. Recently, copy number variations (CNVs) have been used as genetic markers to investigate inter-individual variation. Read More

    Molecular Analysis of Congenital Hypothyroidism in Saudi Arabia: SLC26A7 Mutation is a Novel Defect in Thyroid Dyshormonogenesis.
    J Clin Endocrinol Metab 2018 Mar 12. Epub 2018 Mar 12.
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
    Context: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder, affecting one in 3000-4000 newborns. Since the introduction of a newborn screening program in 1988, more than 300 cases have been identified. The underlying genetic defects have not been systematically studied. Read More

    Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies.
    Sci Rep 2018 Mar 15;8(1):4579. Epub 2018 Mar 15.
    Department of Gerontology, The People's Hospital of China Three Gorges University & The First People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
    It has been reported that subclinical hypothyroidism (SCH) is closely related to subclinical atherosclerosis. According to the impact of SCH on noninvasive markers of cardiovascular risk, we fulfilled a meta-analysis of included studies to provide an integrated overview. We searched electronic databases and included all relevant studies involving SCH and epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), pulse wave velocity (PWV), flow-mediated dilation (FMD) and glyceryl trinitrate-induced dilation (GNT- induced dilation). Read More

    Thyroid function alterations attributed to high iodide supplementation in maternal rats and their offspring.
    J Trace Elem Med Biol 2018 May 2;47:89-97. Epub 2018 Feb 2.
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Electronic address:
    Objective: Our aim was to investigate thyroid function alterations attributed to high iodide supplementation in maternal rats and their offspring.

    Methods: Depending on their iodide intake, the pregnant rats were randomly divided into three groups: normal iodide intake (NI), 10 times high iodide intake (10 HI) and 100 times high iodide intake (100 HI) groups. Iodine concentration in the urine and maternal milk; iodine content and mitochondrial superoxide production; expression of TRα1, TRβ1, NIS and Dio1 in both the thyroid and mammary glands were all measured. Read More

    Associations of maternal iodine status and thyroid function with adverse pregnancy outcomes in Henan Province of China.
    J Trace Elem Med Biol 2018 May 2;47:104-110. Epub 2018 Feb 2.
    Department for Endemic Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China. Electronic address:
    Objective: The study aimed to explore the effects of maternal iodine status and thyroid diseases on adverse pregnancy outcomes.

    Methods: A prospective study was conducted on 2347 pregnant women, who provided 2347 urinary samples tested for iodine, 1082 serum samples tested for thyroid function, and 2347 questionnaires about demographic information. Their pregnancy outcomes were recorded and compared between different urinary iodine concentration (UIC) and thyroid function groups. Read More

    Pseudohyperthyroxinemia in a hypothyroid patient secondary to chronic phlegmon.
    Diagnosis (Berl) 2015 Dec;2(4):245-248
    1Clinical Sciences Division, Northern Ontario Medical School, Ontario, Canada.
    Background: Elevated free thyroxine could be primary or secondary, endogenous or exogenous and often presents with symptoms of hyperthyroidism. Thyroxine levels are low in hypothyroidism, where the individual requires exogenous supplementation to maintain a euthyroid state. However, thyroxine levels may be elevated in a hypothyroid patient because of over-supplementation/over-suppression with exogenous agent(s) or secondary to other pathologies and rarely, laboratory error or assay interference may cause alteration in the levels of the thyroid hormones. Read More

    Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia.
    Saudi Med J 2018 Mar;39(3):254-260
    College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
    Objectives: To estimate the prevalence of subclinical hypothyroidism (SCH) in Saudi Arabia and assess the need for an SCH screening program. Methods: This cross-sectional study was conducted at King Abdulaziz Medical City and the Khashmulaan Clinic at the National Guard Health Affairs, Riyadh, Saudi Arabia in August 2016. All women attending the antenatal clinics were  invited to participate in the study. Read More

    Does TSH Reliably Detect Hypothyroid Patients?
    Ann Thyroid Res 2018 20;4(1):122-125. Epub 2018 Feb 20.
    Department of Laboratory Medicine, NIH, USA.
    Objectives: To evaluate the reliability of normal Thyroid Stimulating Hormone (TSH) as a thyroid function test and assess the effect of Adrenocorticotropic Hormone (ACTH) on serum TSH concentration.

    Design And Methods: Patients presenting to the National Institutes of Health Department of Endocrinology outpatient clinic with symptoms consistent with hypothyroidism were identified. Thyroid hormone concentrations were measured by liquid chromatography/tandem mass spectrometry and immunoassay. Read More

    Evaluation of the congenital hypothyroidism screening programme in Iran: a 3-year retrospective cohort study.
    Arch Dis Child Fetal Neonatal Ed 2018 Mar 14. Epub 2018 Mar 14.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, The Islamic Republic of Iran.
    Objective: To evaluate the newborn screening programme for congenital hypothyroidism (CH) in Iran from diagnosis to management and follow-up for 3 years from 2011 to 2014.

    Design: Retrospective cohort.

    Setting And Patients: Seventeen university districts were randomly selected from 30 provinces. Read More

    Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
    BMJ 2018 03 14;360:k793. Epub 2018 Mar 14.
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, 2nd Floor, New York, NY, USA
    Objective: To evaluate rates of serious organ specific immune-related adverse events, general adverse events related to immune activation, and adverse events consistent with musculoskeletal problems for anti-programmed cell death 1 (PD-1) drugs overall and compared with control treatments.

    Design: Systematic review and meta-analysis.

    Data Sources: Medline, Embase, Cochrane Library, Web of Science, and Scopus searched to 16 March 2017 and combined with data from ClinicalTrials. Read More

    Higher levels of thyrotropin in pregnancy and adverse pregnancy outcomes.
    J Matern Fetal Neonatal Med 2018 Mar 14:1-131. Epub 2018 Mar 14.
    a University Hospital in Mostar , Mostar , Bosnia and Herzegovina.
    Objective: To determine the frequency of subclinical hypothyroidism in women with pathological pregnancies and the association between elevated thyroid-stimulating hormone (TSH) and pregnancy outcome.

    Subjects And Methods: A cross-sectional prospective study investigated value of TSH and free thyroxine (FT4) in: 1. pregnant women with hypertension (HTA) (N = 62) or preeclampsia (PE) (N = 50), 2. Read More

    Traumatic Brain Injury: At the Crossroads of Neuropathology and Common Metabolic Endocrinopathies.
    J Clin Med 2018 Mar 14;7(3). Epub 2018 Mar 14.
    Physiological Genomics, Biomedical Center (BMC), Institute of Physiology, Medical Faculty of the Ludwig-Maximilian University Munich, 82152 Planegg-Martinsried, Germany.
    Building on the seminal work by Geoffrey Harris in the 1970s, the neuroendocrinology field, having undergone spectacular growth, has endeavored to understand the mechanisms of hormonal connectivity between the brain and the rest of the body. Given the fundamental role of the brain in the orchestration of endocrine processes through interactions among neurohormones, it is thus not surprising that the structural and/or functional alterations following traumatic brain injury (TBI) can lead to endocrine changes affecting the whole organism. Taking into account that systemic hormones also act on the brain, modifying its structure and biochemistry, and can acutely and chronically affect several neurophysiological endpoints, the question is to what extent preexisting endocrine dysfunction may set the stage for an adverse outcome after TBI. Read More

    Abnormal Uterine Bleeding In Adolescents.
    J Clin Res Pediatr Endocrinol 2018 Feb 28. Epub 2018 Feb 28.
    Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Read More

    Resolution of consumptive hypothyroidism secondary to infantile hepatic hemangiomatosis with combination propranolol and levothyroxine.
    J Clin Res Pediatr Endocrinol 2018 Feb 28. Epub 2018 Feb 28.
    Infantile hepatic hemangiomas (IHH), particularly of the diffuse subtype, can in severe cases be associated with hepatic and cardiac failure, compartment syndrome, and consumptive hypothyroidism. Early recognition and treatment of these pathologies is paramount in order to minimise the risk of longterm sequelae. We report an interesting case of a female infant who presented with systemic compromise, in the absence of large or obvious cutaneous infantile hemangiomas (IH). Read More

    [Hormone-producing thyroid carcinoma in a female 10-year-old Australian Cattle Dog].
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Feb 21;46(1):35-40. Epub 2018 Feb 21.
    A 10-year-old female Australian Cattle Dog was referred for investigation of a mediastinal mass. During clinical examination, a mandarin- sized mass was detected ventrally of the trachea. According to computed tomographic (CT) findings and cytology of a fine-needle aspirate, thyroid neoplasia was suspected. Read More

    Thyroid Status in Patients with Type 2 Diabetes Attending a Tertiary Care Hospital in Eastern India.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):112-115
    Department of Endocrinology, IPGMER, Kolkata, West Bengal, India.
    Objective: Type 2 diabetes mellitus and thyroid dysfunction (TD) are two major public health endocrine problem, but the prevalence of TD and iodine status in patients with T2 DM in India is less studied. The study objective was to explore the prevalence of TD and to evaluate iodine health in type 2 diabetes patients attending a tertiary care center in Eastern India.

    Methods: Consecutive 100 patients with diabetes attending outpatient department were evaluated clinically and biochemically (thyrotropin [TSH], free thyroxine, anti-TPO antibody, and urinary iodine). Read More

    Prevalence of Hypothyroidism in Term Pregnancies in North India.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):13-15
    Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
    Background: Hypothyroidism is common in pregnancy. No study has determined the prevalence of hypothyroidism in term pregnancies in India.

    Aim: This study aims to determine the prevalence and correlates of hypothyroidism in women who delivered at a center in Karnal, Haryana, North India. Read More

    A Systematic Review on Normative Values of Trimester-specific Thyroid Function Tests in Indian Women.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):7-12
    Department of Clinical Research, Mazumdar Shaw Medical Center, Narayana Health, Bengaluru, Karnataka, India.
    Background: Small cross-sectional studies are published on the trimester-specific normal ranges of thyrotropin and thyroxine levels in Indian women from various parts of the country.

    Objective: We sought to review the published literature on thyroid function tests in normal pregnant Indian women to see if the pooled data from various studies can define normative data and hypothyroidism in pregnancy.

    Methods: We retrieved 56 studies from online databases with detailed search using multiple search terms. Read More

    Normative Trimester-Specific Thyroid Function Data from India: The State of the Nation.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):5-6
    Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
    Background: International guidelines recommend using local trimester-specific normative data for TSH (thyroid stimulating hormone). However, there are no unified Indian data for the same.

    Material And Methods: This review collates recently published data from various Indian centres and discusses the state of trimester-specific TSH ranges in the country. Read More

    Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).
    Sci Rep 2018 Mar 13;8(1):4403. Epub 2018 Mar 13.
    Laboratory of Endocrinology and Receptor Biology, NIDDK, National Institutes of Health, Bethesda, Maryland, 20892, USA.
    Transmembrane proteins that mediate the cellular uptake or efflux of thyroid hormone potentially provide a key level of control over neurodevelopment. In humans, defects in one such protein, solute carrier SLC16A2 (MCT8) are associated with psychomotor retardation. Other proteins that transport the active form of thyroid hormone triiodothyronine (T3) or its precursor thyroxine (T4) have been identified in vitro but the wider significance of such transporters in vivo is unclear. Read More

    Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [F]FDG-PET of Rats.
    Mol Imaging Biol 2018 Mar 12. Epub 2018 Mar 12.
    Nuclear Medicine Division, Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, 116023, China.
    Purpose: Recent researches have demonstrated the value of using 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study focuses on the application of graph theory on analyzing functional brain networks of the hypothyroidism symptom. Read More

    Dynapenia and Sarcopenia as a Risk Factor for Disability in a Falls and Fractures Clinic in Older Persons.
    Open Access Maced J Med Sci 2018 Feb 14;6(2):344-349. Epub 2018 Feb 14.
    Research Group on Geriatrics and Gerontology, Faculty of Health Sciences, International Association of Gerontology and Geriatrics Collaborative Centre, University of Caldas, Manizales, Colombia.
    Background: The role of sarcopenia and dynapenia in disability in older persons from falls and bone health clinics remain unknown.

    Aim: This study aims to compare the association of sarcopenia and dynapenia with physical and instrumental disability in a population of older persons attending a falls and fractures clinic.

    Methods: This is a cross-sectional study in Manizales, Andes Mountains, Colombia. Read More

    Decreased sensitivity of thyrotropin-thyroid hormone feedback control in hypothyroid and athyreotic patients treated with levothyroxine. Is serum triiodothyronine involved?
    Ann Endocrinol (Paris) 2018 Mar 9. Epub 2018 Mar 9.
    Department of endocrinology, Sisters of Mercy university hospital center, medical school, university of Zagreb, Zagreb, Croatia. Electronic address:
    Objectives: The search for optimal therapy for hypothyroidism is challenging and complex and is still going on. We investigated TSH-thyroid hormone feedback control in hypothyroid and athyreotic patients properly treated with levothyroxine (LT4), based on normal TSH values.

    Material And Methods: We randomly selected 150 hypothyroid, 110 athyreotic and 210 euthyroid subjects, determined their serum T4, T3 and TSH values and calculated T4/TSH and T3/T4 ratios. Read More

    [Advances in genetic research of congenital hypothyroidism in China].
    Zhongguo Dang Dai Er Ke Za Zhi 2018 Mar;20(3):243-250
    Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang 110004, China.
    Congenital hypothyroidism (CH), which results from insufficient thyroid hormone biosynthesis, is one of the most common neonatal endocrine disorders. Thyroid dysgenesis and thyroid dyshormonogenesis are the two causes of CH and either one will lead to deficiencies of enzymes during thyroid hormone biosynthesis and insufficient thyroid hormone biosynthesis. Recently, researchers have performed extensive studies on genetics of CH. Read More

    Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology.
    Korean J Intern Med 2018 Mar 13. Epub 2018 Mar 13.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
    Background/aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.

    Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. Read More

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