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    41725 results match your criteria Hypothyroidism

    1 OF 835

    [General internal medicine : 2017 scientific breakthroughs in ambulatory care].
    Rev Med Suisse 2018 Jan;14(590):130-134
    Policlinique médicale universitaire, Rue du Bugnon 44, 1011 Lausanne.
    Bariatric surgery improves glycemic control in obese patients with diabetes type 2. Dual antiplatelet therapy can be maintained beyond 12 months after a myocardial infarction. Levothyroxine is not beneficial among patients ≥ 65 years that have subclinical hypothyroidism. Read More

    Urgent Need to Define Pretreatment Predictors of Immune Check Point Inhibitors Related Endocrinopathies: A Case Report and Review of Literature.
    J Transl Int Med 2017 Dec 29;5(4):235-239. Epub 2017 Dec 29.
    University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
    Immune check point inhibitors have revolutionized the treatment of metastatic malignancies. They are a promising area in oncology and more drugs are likely to be available in the coming years. Along with the promise of better response oncologically, there is an increased incidence of endocrinopathies related to autoimmunity. Read More

    Alterations of global DNA methylation and DNMT expression in T and B lymphocytes from patients with newly diagnosed AITD after treatment: A follow-up study.
    Thyroid 2018 Jan 16. Epub 2018 Jan 16.
    Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning, China.
    Background: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune disorders. The aims of this study were to identify global DNA methylation patterns in patients with autoimmune thyroid diseases (AITDs) and to observe methylation changes after treatment for these conditions.

    Methods: We conducted a cross-sectional study design including the following patients: 51 with newly diagnosed Graves' disease (GD), 28 with autoimmune hypothyroidism (AIT), 29 with positive thyroid autoantibodies (pTAb) and 39 matched healthy volunteers. Read More

    A hot-spot mutation in CDC42 (p.Tyr64Cys) and novel phenotypes in the third patient with Takenouchi-Kosaki syndrome.
    J Hum Genet 2018 Jan 15. Epub 2018 Jan 15.
    Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Takenouchi-Kosaki syndrome (TKS) is a congenital malformation syndrome characterized by severe developmental delay, macrothrombocytopenia, camptodactyly, sensorineural hearing loss, and dysmorphic facial features. Recently, a heterozygous de novo mutation (p.Tyr64Cys) in the CDC42 gene, which encodes a key small GTP-binding protein of the Rho-subfamily, was identified in two unrelated patients with TKS. Read More

    Diagnostic reevaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism.
    Endocr Connect 2018 Jan 15. Epub 2018 Jan 15.
    M Kocova, University Children's Hospital Skopje, Skopje, Macedonia (the former Yugoslav Republic of).
    Background: Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors for distinguishing between permanent (PCH) and transient CH (TCH). Read More

    Prevalence and risk factors of hyperprolactinemia among patients with various psychiatric diagnoses and medications.
    Int J Psychiatry Clin Pract 2018 Jan 15:1-8. Epub 2018 Jan 15.
    g Mental Health Hospital , Abha , Saudi Arabia.
    Objectives: Hyperprolactinemia is a common adverse event associated with psychotropic medications (mainly antipsychotics) used in the management of schizophrenia and bipolar disorders. The aim of this study was to estimate the prevalence of hyperprolactinemia in psychiatric patients and to evaluate its association with various psychiatric diagnoses and the use of various psychotropic medications.

    Methods: A cross-sectional observational study was conducted between July 2012 and June 2014. Read More

    Hashimoto's disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term.
    Arch Argent Pediatr 2018 Feb;116(1):56-58
    Departamento de Farmacología, Pediatría y Química Orgánica, Universidad Miguel Hernández de Elche, San Juan de Alicante, Alicante (España).
    Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Read More

    c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model.
    J Mol Histol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Pediatrics, Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong, 226001, Jiangsu Province, China.
    The EphA5 receptor is well established as an axon guidance molecule during neural system development and plays an important role in dendritic spine formation and synaptogenesis. Our previous study has showed that EphA5 is decreased in the developing brain of congenital hypothyroidism (CH) and the EphA5 promoter methylation modification participates in its decrease. c-Fos, a well-kown transcription factor, has been considered in association with brain development. Read More

    Rectal Atresia and Congenital Hypothyroidism: An Association or Coincidence?
    European J Pediatr Surg Rep 2018 Jan 10;6(1):e7-e10. Epub 2018 Jan 10.
    Department of Pediatric Surgery, Dortcelik Children's Hospital, Bursa, Turkey.
    Rectal atresia is a rare anorectal malformation, and its association with other anomalies is even more rare. This study presents a unique case of co-twin in which the surviving newborn male underwent surgery due to rectal atresia. Newborn screening tests identified congenital hypothyroidism. Read More

    Age, Sex, and Gene Expression Score identifies a symptomatic, nondiabetic male patient as being at high risk of obstructive coronary artery disease.
    SAGE Open Med Case Rep 2018 4;6:2050313X17749081. Epub 2018 Jan 4.
    Berks Cardiologists, Ltd, Wyomissing, PA, USA.
    In October 2015, a 74-year-old Caucasian male patient (past medical history of hyperlipidemia, paroxysmal atrial fibrillation, hypertension, and hypothyroidism) presented to the cardiologist for follow-up outpatient evaluation of exertional chest pain. The patient had recently been seen at the Emergency Department for the same complaint. At that time, the patient's cardiac markers, EKG, and pharmacological nuclear stress testing were all reported as normal. Read More

    Microvascular Outcomes of Pediatric-Onset Type 1 Diabetes Mellitus: A Single-Center Observational Case Reviews in Sana'a, Yemen.
    Clin Med Insights Endocrinol Diabetes 2018 3;11:1179551417749217. Epub 2018 Jan 3.
    Department of Medicine, Sana'a University, Sana'a, Yemen.
    Microvascular complications of pediatric-onset type 1 diabetes are common in low-income countries. In this study, we aimed at reviewing microvascular outcomes in 6 cases with type 1 diabetes over 14 to 31 years of follow-up. Severe proliferative diabetic retinopathy (PDR) and/or diabetic macular edema (maculopathy) (DME) and overt diabetic nephropathy (macroalbuminuria) were seen among 4 of 6 patients, whereas severe diabetic peripheral neuropathy with Charcot neuroarthropathy was seen in 1 patient only, who had the longest duration of follow-up. Read More

    18p Deletion Syndrome: Case Report with Clinical Consideration and Management.
    Contemp Clin Dent 2017 Oct-Dec;8(4):632-636
    Department of Oral Medicine and Radiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.
    18p deletion syndrome is characterized by the deletion of short arm of chromosome 18. Presentation of this syndrome is quite variable with dysmorphic features, growth deficiencies, and mental retardation with poor verbal performance. Few patients even fail to thrive when malformations involving the heart and brain are severe. Read More

    Is hypothyroidism in idiopathic pleuroparenchymal fibroelastosis a novel lung-thyroid syndrome?
    Respir Investig 2018 Jan 7;56(1):48-56. Epub 2017 Oct 7.
    Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan. Electronic address:
    Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare type of interstitial pneumonia characterized by fibroelastosis. Patients with IPPFE as well as idiopathic interstitial pneumonia often have autoimmune diseases, which sometimes coincide with hypothyroidism (HypoT). However, there have been no reports on the association between IPPFE and HypoT. Read More

    Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2018 Jan 11. Epub 2018 Jan 11.
    NIHR Collaboration for Leadership in Applied Health Research and Care South West Peninsula (PenCLAHRC), University of Exeter, Medical School, University of Exeter, Exeter, UK.
    Background: In the last two decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results.

    Aim: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes. Read More

    Mean high dose L-thyroxine treatment is efficient and safe to achieve a normal IQ in young adult patients with congenital hypothyroidism.
    J Clin Endocrinol Metab 2018 Jan 9. Epub 2018 Jan 9.
    Institute for Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Germany.
    Context: The optimal levothyroxine (LT4) dose required to treat congenital hypothyroidism (CH) remains unclear, with a debate if higher starting doses (>10µg/kg) are necessary and safe for normal Intelligence Quotient (IQ).

    Objective: To examine the psychomotor, metabolic and quality of life outcome in patients with CH treated with a mean high initial LT4 dose.

    Design, Settings, Participants: A cross- sectional cohort study of CH patients identified in the Berlin newborn screening programme from 1979-2003. Read More

    TSH and FT4 concentrations in congenital central hypothyroidism and mild congenital thyroidal hypothyroidism.
    J Clin Endocrinol Metab 2018 Jan 9. Epub 2018 Jan 9.
    TNO, Department of Child Health, Leiden, The Netherlands.
    Context: In central hypothyroidism (CeH) free thyroxine (FT4) concentrations are low while TSH concentrations may be low, normal or even slightly elevated due to reduced bioactivity. Congenital CeH (CCeH) may be isolated or part of multiple pituitary hormone deficiency (MPHD).

    Objective: To test our hypotheses that (1) TSH concentrations have a more U-shaped distribution in children with CCeH compared to children with a normally functioning hypothalamic-pituitary-thyroid-axis, and (2) TSH concentrations in children with CCeH with MPHD are higher compared to children with isolated CCeH. Read More

    Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients.
    Endocr J 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
    Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Read More

    Secondary and tertiary preventions of thyroid disease.
    Endocr Res 2018 Jan 10:1-17. Epub 2018 Jan 10.
    a Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
    Introduction: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness.

    Methods: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. Read More

    Sexual function and depressive symptoms in young men with hypothyroidism receiving levothyroxine/liothyronine combination therapy.
    Endokrynol Pol 2018 Jan 10. Epub 2018 Jan 10.
    Introduction: Both overt and subclinical hypothyroidism are often accompanied by sexual dysfunction. Despite improving male sexual functioning, levothyroxine treatment does not always restore all its aspects. The aim of this study was to compare male sexual functioning and depressive symptoms between men with hypothyroidism receiving levothyroxine/liothyronine combination therapy and men receiving levothyroxine alone. Read More

    Impact of positive thyroid autoimmunity on pregnant women with subclinical hypothyroidism.
    Endocrinol Diabetes Nutr 2018 Jan 6. Epub 2018 Jan 6.
    Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Departamento de Medicina, Facultad de Medicina, Universidad de Cádiz, Cádiz, España.
    Background: The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial.

    Aim: To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population.

    Material And Method: A retrospective cohort study in 435 women with SH (TSH ranging from 3. Read More

    Effects of thyroid stimulating hormone on peripheral thyroid hormone metabolism and serum lipids.
    Thyroid 2018 Jan 9. Epub 2018 Jan 9.
    Erasmus MC, Dept of Internal Medicine, Dept of Endocrinology , 's Gravendijkwal 230 , Room H555 , Rotterdam, Netherlands , 3015CE ;
    Background: Subclinical hypothyroidism is associated with dyslipidemia and atherosclerosis. Whether part of these effects are mediated via direct effects of TSH on peripheral TH metabolism and/or concentrations of serum lipids is not clear.

    Objective: To examine whether thyroid stimulating hormone (TSH) has direct effects on peripheral thyroid hormone (TH) metabolism and serum lipids. Read More

    Characteristics and comorbidities of inpatients without celiac disease on a gluten-free diet.
    Eur J Gastroenterol Hepatol 2018 Jan 8. Epub 2018 Jan 8.
    Celiac Disease Center, Columbia University College of Physicians and Surgeons.
    Objectives: Despite the increasing popularity of gluten-free diet (GFD), the demographic characteristics and medical features of patients without celiac disease on this diet have not been extensively investigated.We aimed to characterize the medical conditions and demographic backgrounds of hospitalized patients without celiac disease who adhere to a GFD, to further understand their reasons for gluten avoidance.

    Materials And Methods: We performed an observational cohort study on all inpatients at Columbia University Medical Center on a GFD in 2011-2016, excluding those with celiac disease, compared with age-matched and sex-matched inpatients on a regular diet. Read More

    Endocrine dysfunction induced by immune checkpoint inhibitors: Practical recommendations for diagnosis and clinical management.
    Cancer 2018 Jan 3. Epub 2018 Jan 3.
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.
    Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. However, because ICIs block coinhibitory molecules on T cells and other immune cells, unleashing them to mediate tumor cell killing, they also can disrupt the maintenance of immunological tolerance to self-antigens. Compared with chemotherapy, ICIs have a different toxicity profile, especially the occurrence of autoimmune-like manifestations against multiple organ systems, including endocrine glands, commonly referred to as immune-related adverse events. Read More

    Evaluation of Risk Factors for Exchange Range Hyperbilirubinemia and Neurotoxicity in Neonates from Hilly Terrain of India.
    Int J Appl Basic Med Res 2017 Oct-Dec;7(4):228-232
    Department of Pediatrics, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.
    Background And Aim: Neonatal hyperbilirubinemia continues to be the most common cause of hospital admissions and readmissions in the neonatal population worldwide and this pattern continues despite attempts to identify neonates at risk of pathological hyperbilirubinemia. Therefore, this study aimed to study the risk factors for severe hyperbilirubinemia in neonates.

    Materials And Methods: An observational prospective study was undertaken for 1 year in neonates with hyperbilirubinemia requiring double volume exchange transfusion in neonatology unit of a tertiary rural health care hospital. Read More

    Voluntary exercise training restores anticontractile effect of NO in coronary arteries of adult rats with antenatal/early postnatal hypothyroidism.
    Nitric Oxide 2018 Jan 5;74:10-18. Epub 2018 Jan 5.
    Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1/12, 119234, Moscow, Russia; Institute for Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe Shosse 76A, 123007, Moscow, Russia.
    Introduction: Our recent study showed that NO-mediated anticontractile effect of endothelium is absent in coronary arteries of adult rats, which suffered from antenatal/early postnatal hypothyroidism. This study tested the hypothesis that exercise training would improve such detrimental consequences of early thyroid deficiency.

    Design And Methods: Wistar dams received propylthiouracil (PTU, 7 ppm) in drinking water during gestation and two weeks postpartum; control dams received tap water. Read More

    Management of thyrotoxicosis in children and adolescents: 35 years' experience in 304 patients.
    J Pediatr Endocrinol Metab 2018 Jan 8. Epub 2018 Jan 8.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
    Background: Diffuse toxic goiter accounts for about 15% of all childhood thyroid diseases. There is great controversy over the management of Graves' disease in children and adolescents. This article reports our experience in 304 children and juvenile patients with Graves' disease. Read More

    Impact of subclinical hypothyroidism on clinical outcomes following percutaneous coronary intervention.
    Int J Cardiol 2018 Feb;253:155-160
    Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
    Background: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear.

    Methods: We performed a prospective cohort study. Read More

    Cardiac ischemia/reperfusion injury is inversely affected by thyroid hormones excess or deficiency in male Wistar rats.
    PLoS One 2018 5;13(1):e0190355. Epub 2018 Jan 5.
    Laboratory of Cardiovascular Physiology and Pharmacology, Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, Seropedica-RJ, Brazil.
    Aim: Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, the repercussions on cardiac ischemia/reperfusion (IR) injury remain unclear so far. We report here the effects of hypothyroidism and thyrotoxicosis in the susceptibility to IR injury in isolated rat hearts compared to euthyroid condition and the potential role of antioxidant enzymes. Read More

    Veganism as a cause of iodine deficient hypothyroidism.
    J Pediatr Endocrinol Metab 2018 Jan;31(1):91-94
    Pediatric Endocrinology, Goryeb Children's Hospital, Atlantic Health System, 100 Madison Ave., Morristown, NJ 07962, USA.
    Background: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide. Although uncommon in the Western world, the incidence of iodine deficiency may be rising due to the increased use of restrictive diets.

    Case Presentation: We present a 23-month-old boy diagnosed with iodine deficiency hypothyroidism, induced by a vegan diet. Read More

    Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status.
    Physiol Res 2018 Jan 5. Epub 2018 Jan 5.
    Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
    Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. Read More

    Pomalidomide-induced hypothyroidism.
    Endocrinol Diabetes Metab Case Rep 2017 15;2017. Epub 2017 Dec 15.
    Endocrinology Department, Mater Misericordiae University Hospital, Dublin, Ireland.
    Hypothyroidism is a recognized side effect of thalidomide drugs. We herein report a case of 83-year-old Irish female with a diagnosis of multiple myeloma and a background history of type 2 diabetes mellitus and hypertension. Our patient received pomalidomide and multiple courses of chemotherapy and achieved very good initial response for her multiple myeloma but subsequently she relapsed. Read More

    Efficacy, safety and pharmacokinetics of axitinib in nasopharyngeal carcinoma: a preclinical and phase 2 correlative study.
    Clin Cancer Res 2018 Jan 4. Epub 2018 Jan 4.
    Department of Clinical Onology, The Chinese University of Hong Kong
    Purpose: We hypothesized that axitinib is active with improved safety profile in nasopharyngeal carcinoma (NPC).

    Experimental Design: We evaluated axitinib in preclinical models of NPC, and studied its efficacy in a phase 2 clinical trial in recurrent or metastatic NPC patients who progressed after at least one line of prior platinum-based chemotherapy. We excluded patients with local recurrence or vascular invasion. Read More

    Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.
    Int J Mol Sci 2018 Jan 1;19(1). Epub 2018 Jan 1.
    Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (38), Riyadh 11461, Saudi Arabia.
    Thyroid hormone is a potent stimulator of metabolism, playing a critical role in regulating energy expenditure and in key physiological mechanisms, such as growth and development. Although administration of thyroid hormone in the form of levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, the precise molecular basis of its physiological actions remains uncertain. Our objective was to define the changes in circulating protein levels that characterize alterations in thyroid hormone status. Read More

    Clinical course of infants with congenital heart disease who developed thyroid dysfunction within 100 days.
    Ann Pediatr Endocrinol Metab 2017 Dec 31;22(4):253-258. Epub 2017 Dec 31.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Purpose: We investigated the clinical course of infants with congenital heart disease (CHD) who experienced thyroid dysfunction within 100 days of birth.

    Methods: We performed retrospective medical reviews of 54 CHD patients (24 male patients) who underwent a thyroid function test (TFT) between January 2007 and July 2016. Data were collected on birth history, diagnosis of CHD, underlying chromosomal or genetic abnormalities, medication history, surgery, ventilator care, and exposure to iodine contrast media (ICM). Read More

    The metabolism and significance of homocysteine in nutrition and health.
    Nutr Metab (Lond) 2017 22;14:78. Epub 2017 Dec 22.
    Environmental Toxicology Department, Southern University and A&M College, Baton Rouge, LA 70813 USA.
    An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, stroke, and cardiovascular disease (CVD). Read More

    Levothyroxine supplementation improves serum anti-Müllerian hormone levels in infertile patients with Hashimoto's thyroiditis.
    J Obstet Gynaecol Res 2018 Jan 3. Epub 2018 Jan 3.
    Shinbashi Yume Clinic, Tokyo, Japan.
    Aim: Thyroid dysfunction and autoimmunity are associated with an adverse effect on fertility. An aberrant high thyroid stimulating hormone level is associated with diminished ovarian reserve in women of reproductive age; however, the utility of levothyroxine (LT4) replacement for infertile patients with subclinical hypothyroidism is still under discussion. The aim of this study was to investigate whether LT4 supplementation for infertile patients with subclinical hypothyroidism improves impaired ovarian function. Read More

    Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.
    J Clin Endocrinol Metab 2017 Dec 26. Epub 2017 Dec 26.
    Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
    Context: Overt thyroid disease in pregnancy is a known risk factor for abnormal fetal growth and development. Data on the effects of milder forms of variation in maternal thyroid function on intrauterine growth are less well examined.

    Objective: We aimed to explore these associations using repeated thyroid hormone and ultrasound measurements. Read More

    Correlation between immune-related adverse events and efficacy in non-small cell lung cancer treated with nivolumab.
    Lung Cancer 2018 Jan 21;115:71-74. Epub 2017 Nov 21.
    Third Department of Internal Medicine, Wakayama Medical University, Japan.
    Objectives: Patients treated with nivolumab often experience its unique adverse events, called immune-related adverse events (irAEs). Regarding the mechanisms of immune-checkpoint inhibitors (ICIs), the occurrence of irAEs may also reflect antitumor responses. Here, we report the clinical correlation between irAEs and efficacy in NSCLC patients treated with nivolumab. Read More

    The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats.
    Metab Brain Dis 2017 Dec 30. Epub 2017 Dec 30.
    Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0. Read More

    Health problems in females carriers of premutation in the FMR1 gene.
    Psychiatr Pol 2017 Oct 29;51(5):899-907. Epub 2017 Oct 29.
    Zakład Genetyki Klinicznej, Katedra i Zakład Biologii Molekularnej i Genetyki, Śląski Uniwersytet Medyczny w Katowicach.
    Premutation in the FMR1 gene occur in the general population with an estimated prevalence 1 in 130-260 females and 1 in 250-810 males. Carriers of premutation are at risk of development of spectrum of neurological, psychiatric and immunological disorders in adulthood. Fragile X-associated disease caused by dynamic mutation (expansion of CGG repeats) can be divided into three disorders: FXS - Fragile X syndrome, FXPOI - Fragile X-associated primary ovarian insufficiency, FXTAS -Fragile X-associated tremor/ataxia syndrome, which can be present in few generations of one family. Read More

    l-Thyroxine-responsive drop attacks in childhood benign hereditary chorea: A case report.
    Brain Dev 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
    Benign hereditary chorea (BHC) is a rare autosomal dominant disease that is characterized by non-progressive chorea with early-childhood-onset, congenital hypothyroidism, and neonatal respiratory distress. Although tetrabenazine and levodopa are partly effective for chorea and drop attacks in some patients, there is no standard treatment option. We herein describe a childhood case of BHC that presented with l-thyroxine-responsive drop attacks. Read More

    Are multisource levothyroxine sodium tablets marketed in Egypt interchangeable?
    Ann Endocrinol (Paris) 2017 Dec 27. Epub 2017 Dec 27.
    Department of pharmaceutical Sciences, School of Pharmacy, University of Saint Joseph (USJ), Hartford, CT 06103, USA.
    A clinical study was initiated in response to patients' complaints, supported by the treating physicians, of suspected differences in efficacy among multisource levothyroxine sodium tablets marketed in Egypt. The study design was a multiple dose (100μg levothyroxine sodium tablet once daily for 6 months) and involved 50 primary hypothyroidism female patients (5 equal groups). Tablets administered included five tablet batches (two brands, three origin locations) purchased from local pharmacies in Alexandria. Read More

    Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity.
    J Endocrinol Invest 2017 Dec 29. Epub 2017 Dec 29.
    Unit of Endocrinology, Department of Medico-Surgical Sciences and Biotechnologies, AUSL Latina, "Sapienza" University of Rome, Rome, Italy.
    Purpose: Hyperhomocysteinemia is a known cardiovascular risk factor and a key player in the inflammatory activation of autoimmune diseases. Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism which, in itself, has been associated with a significant raise of homocysteine (Hcy) levels and increased cardiovascular risk. Our aim was to assess the impact of HT on Hcy levels in patients with acute hypothyroidism. Read More

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