J Pediatr (Rio J) 2017 Jul 21. Epub 2017 Jul 21.

Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil.

Objectives: To determine the prevalence of congenital hypothyroidism in children with filter paper thyroid-stimulating hormone levels between 5 and 10μUI/mL in the neonatal screening.

Methods: This was a retrospective study including children screened from 2003 to 2010, with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum thyroid-stimulating hormone normalization. The diagnosis of congenital hypothyroidism was defined as serum thyroid-stimulating hormone ≥10μIU/mL and start of levothyroxine treatment up to 2 years of age. Read More

Scand J Clin Lab Invest 2017 Jul 24:1-6. Epub 2017 Jul 24.

a Department of Clinical Biochemistry , Aalborg University Hospital , Aalborg , Denmark.

Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD). The aim of the study was to compare the diagnostic performance and assay agreement between three immunoassays for the measurement of TRAb in patients with newly diagnosed GD. TRAb was measured with three different assays [H-TRAb (BRAHMS Diagnostica), M22-Man (RSR Limited) and M22-Aut (Roche Diagnostics)] in 387 participants who were recruited from two Danish population-based studies and diagnosed with GD (n = 101), multinodular toxic goitre (n = 88), primary autoimmune hypothyroidism (n = 100) or included as controls (n = 98). Read More

Ir Med J 2017 May 10;110(5):559. Epub 2017 May 10.

National Maternity Hospital, Holles Street, Dublin 2.

Andrologia 2017 Jul 23. Epub 2017 Jul 23.

Faculty of Physical Education and Sport Sciences, Department of Physical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

This study was conducted to determine the effects of 8-week administration of testosterone enanthate (TE) in conjunction with resistance training on thyroid hormones and lipid profiles. Sixty male adult Wistar rats were randomly divided into six groups: C: olive oil, RT: resistance training + olive oil, LD: TE (20 mg/kg), HD: TE (50 mg/kg), RT + LD: RT + TE (20 mg/kg), RT + HD: RT + TE (50 mg/kg). The RT consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail. Read More

J Med Genet 2017 Jul 22. Epub 2017 Jul 22.

Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council, Naples, Italy.

Background: The laminin alpha 5 gene (LAMA5) plays a master role in the maintenance and function of the extracellular matrix (ECM) in mammalian tissues, which is critical in developmental patterning, stem cell niches, cancer and genetic diseases. Its mutations have never been reported in human disease so far. The aim of this study was to associate the first mutation in LAMA5 gene to a novel multisystem syndrome. Read More

Oncotarget 2017 Jun 29. Epub 2017 Jun 29.

Department of ICU, Tianjin City Second People's Hospital, Tianjin, China.

Abnormality of thyroid hormones in liver diseases is common, but data is lacking in patients with type A hepatic encephalopathy (HE). The present study was aimed to determine whether there was an abnormality in thyroid hormones among patients with type A HE. We measured the levels of thyroid hormones in 36 acute liver failure (ALF) patients with type A HE and in 29 acute liver injury patients (international normalized ratio, INR ≥ 1. Read More

J Photochem Photobiol B 2017 Jul 12;173:681-685. Epub 2017 Jul 12.

Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal University of Bahia, Salvador, Brazil. Electronic address:

Thyroid hormones influence both development and growth of organs and tissues and guarantee metabolic demands that interfere with the quality of digestive secretions, including those of the salivary glands. Laser phototherapy - LPT can modulate various biological phenomena and its diverse effects permit the action on different cell types. The aim of this study was to evaluate the influence of laser phototherapy on myoepithelial cells of salivary glands of hypothyroid rats. Read More

J Appl Res Intellect Disabil 2017 Jul 20. Epub 2017 Jul 20.

General Practice and Primary Care research group, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Background: In the UK, general practitioners/family physicians receive pay for performance on management of long-term conditions, according to best-practice indicators.

Method: Management of long-term conditions was compared between 721 adults with intellectual disabilities and the general population (n = 764,672). Prevalence of long-term conditions was determined, and associated factors were investigated via logistic regression analyses. Read More

Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

Lancet Oncol 2017 Jul 17. Epub 2017 Jul 17.

Westmead Hospital, Westmead, NSW, Australia; Melanoma Institute Australia, University of Sydney, Sydney, NSW, Australia; Blacktown Hospital, Blacktown, NSW, Australia.

Background: Reduced-dose nivolumab in combination with standard-dose ipilimumab improves objective response and progression-free survival compared with standard-dose ipilimumab alone, but increases toxicity. We assessed the safety and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimumab.

Methods: In this open-label, phase 1b trial, we recruited patients from 12 medical centres in Australia, New Zealand, and the USA. Read More

Am J Obstet Gynecol 2017 Jul 17. Epub 2017 Jul 17.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Prematurity is known to be associated with high rates of endocrine and metabolic complications in the offspring. Early term (37 0/7-38 6/7 weeks' gestation) born offspring were also shown to exhibit long term morbidity resembling that of late preterm, in several health categories.

Objective: We aimed to determine whether early term delivery impacts on the long-term endocrine and metabolic health of the offspring. Read More

Rev Colomb Psiquiatr 2017 Jul - Sep;46(3):140-146. Epub 2016 Aug 7.

Universidad El Bosque, Bogotá, Colombia.

Introduction: Hypothyroidism results from inadequate production of thyroid hormone. It is known that there is a relationship between the major psychiatric disorders and hypothyroidism.

Objective: To determine the prevalence of hypothyroidism in patients admitted due to major psychiatric disorders in Montserrat Hospital during the period from March to October 2010. Read More

Pharmacogenet Genomics 2017 Jul 19. Epub 2017 Jul 19.

aDivision of Molecular and Clinical Medicine, School of Medicine bCentre for Pharmacogenetics and Pharmacogenomics cMedicines Monitoring Unit (MEMO) and Hypertension Research Centre (HRC) dDepartment of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

Objective: Replication of associations in genome-wide association studies is desirable to ensure that such signals are potentially clinically meaningful. This study aimed to replicate associations of selected single-nucleotide polymorphisms (SNPs) with hypothyroidism and serum thyroid-stimulating hormone (TSH) using electronic medical records (EMRs).

Patients And Methods: A cross-sectional study was carried out among patients of European Caucasian ethnicity from the Genetics of Diabetes Audit and Research Tayside recruited in Tayside (Scotland, UK). Read More

J Pediatr Endocrinol Metab 2017 Jul 20. Epub 2017 Jul 20.

.

Background: Increased thyroid stimulating hormone (TSH) serum concentration can be a marker of subclinical hypothyroidism (SCH) or transient hyperthyrotropinemia. The aim of our study was to evaluate whether high serum TSH concentrations in allergic children could represent true SCH or isolated and transient hyperthyrotropinemia.

Methods: We enrolled 620 allergic children (1. Read More

Clin Endocrinol (Oxf) 2017 Jul 20. Epub 2017 Jul 20.

Department of Endocrinology and Metabolism, Odense University Hospital, Denmark. Kloevervaenget 10, 6th floor, 5000, Denmark.

Background: The triggering of thyroid autoimmunity in the genetically susceptible remains a conundrum. Environmental exposures during gestation and/or early postnatally have proponents, as suggested in diabetes mellitus, with a higher incidence of births during spring and summer. Whether the development of autoimmune hypothyroidism (AIT) is influenced by month or season of birth is less clear. Read More

Endocrine 2017 Jul 19. Epub 2017 Jul 19.

University Hospital of Endocrinology, Sofia, Bulgaria.

Background: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population.

Purpose: A cross-sectional case-control study was carried out in a single tertiary referral centre. Read More

BMJ Case Rep 2017 Jul 19;2017. Epub 2017 Jul 19.

Paediatrics, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.

Ital J Pediatr 2017 Jul 19;43(1):61. Epub 2017 Jul 19.

Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.

Background: Recurrent reciprocal 1q21.1 deletions and duplications have been associated with variable phenotypes. Phenotypic features described in association with 1q21. Read More

J Clin Pharmacol 2017 Jul 19. Epub 2017 Jul 19.

Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.

Despite evidence linking thyroxin use and breast cancer, little is known regarding the risk of other cancers with thyroxin use. The purpose of this case-control study was to evaluate the association of thyroid cancer with primary hypothyroidism based on a population-based database. The data for this case-control study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. Read More

Eur Rev Med Pharmacol Sci 2017 Jun;21(2 Suppl):51-59

Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy.

Objective: Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function.

Patients And Methods: A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone. Read More

Eur Rev Med Pharmacol Sci 2017 Jun;21(2 Suppl):36-42

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Objective: The beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism have been recently demonstrated. Here, we evaluate the immune-modulating effect of myo-inositol in association with seleno-methionine in patients with euthyroid autoimmune thyroiditis (AT).

Patients And Methods: Twenty-one consecutive Caucasian patients with newly diagnosed euthyroid chronic AT were evaluated. Read More

PLoS One 2017 19;12(7):e0176361. Epub 2017 Jul 19.

Depatment of Community Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra, State Nigeria.

Background: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria.

Methods: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi. They were all premenopausal females with regular menstrual cycle and aged between 15-45 years. Read More

Prz Menopauzalny 2017 Jun 30;16(2):33-37. Epub 2017 Jun 30.

Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland.

The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Read More

J Ayub Med Coll Abbottabad 2016 Apr-Jun;28(2):312-314

Department of Medicine, Women Medical College, Abbottabad, Pakistan.

Background: Sub-clinically hypo-functioning thyroid is a condition in which there is biochemical evidence of hypothyroidism but patient is clinically asymptomatic. This concept is not new. The typical picture of this condition is increased thyroid stimulating hormone and normal thyroxine levels. Read More

Horm Metab Res 2017 Jul 17. Epub 2017 Jul 17.

Department of Zoology, University of Calcutta, Kolkata, West Bengal, India.

Current study was aimed to screen the SLC26A4 gene in 127 nonautoimmune and noncongenital hypothyroid patients, who were under optimal iodine nutrition and devoid of any characteristics of Pendred syndrome from eastern part of Indian population. 8 single nucleotide variants/mutations were identified in heterozygous state in 20% patient population, which include 1 novel nonsynonymous (p.C18S), 1 novel intronic (g. Read More

CMAJ 2017 Jul;189(28):E941

Division of General Internal Medicine (Wyne), McMaster DeGroote School of Medicine; McMaster University (Deshauer), Hamilton, Ont.

Evid Based Med 2017 Jul 17. Epub 2017 Jul 17.

Departments of Medicine, Obstetrics & Gynecology, and Medical Education, University of Illinois College of Medicine Rockford, Rockford, Illinois, USA.

Mol Med Rep 2017 Sep 14;16(3):3233-3241. Epub 2017 Jul 14.

Department of Endocrinology, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

The aim of the present study was to observe the effects of the concurrent administration of thyroxine (T4) and an acetylcholinesterase (AChE) inhibitor, donepezil (DON), on the hypothyroidism‑induced ultrastructural changes of the prefrontal cortex (PFC) in adult rats. The acetylcholine (ACh) content and AChE activity was assessed, as well as the expressions of synaptotagmin‑1 (syt‑1) and SNAP‑25 were analyzed in the rats. Adding 0. Read More

Case Rep Med 2017 21;2017:4297372. Epub 2017 Jun 21.

Department of Internal Medicine, University Hospital of Heraklion, Crete, Greece.

Sinus bradycardia which is a sinus rhythm with a resting heart rate of less than 60 bpm is caused by intrinsic cardiac disorders like sick sinus syndrome or inferior myocardial infarction, metabolic and environmental causes (such as hypothyroidism and electrolyte disorders), medications (such as beta-blockers and amiodarone), infection (such as myocarditis), increased intracranial pressure, and toxic exposure, while it can sometimes be a normal phenomenon, especially during sleep, in athletes, and during pregnancy. Symptomatic sinus bradycardia should warrant a thorough work-up in order to identify any reversible causes; otherwise, placement of a permanent pacemaker could be needed. We present the case of a patient who was admitted due to confusion and fever and was found to have pneumococcal meningitis and bacteremia, and during his hospital stay he developed symptomatic sinus bradycardia that was of intractable cause and persistent. Read More

Front Endocrinol (Lausanne) 2017 30;8:137. Epub 2017 Jun 30.

Unit of Endocrinology, Department of Medicine and Sciences of Aging, Ce.S.I.-Me.T., University of Chieti-Pescara, Chieti, Italy.

Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. Read More

J Microbiol Immunol Infect 2017 Jun 28. Epub 2017 Jun 28.

Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: To investigate the association of systemic lupus erythematosus (SLE) with thyroid diseases in a medical center in central Taiwan.

Methods: This is a retrospective cohort of 2796 SLE patients in a tertiary referral medical center from 2000 to 2013. We screened SLE by catastrophic illness registration from national insurance bureau; and thyroid diseases by ICD 9 codes, then confirmed by thyroid function test, auto-antibody, medical and/or surgical intervention. Read More

J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):605-608

Department of Internal Medicine, Dubai Hospital, Dubai Health Authority, U.A.E.

A 41 year old Jordanian gentleman known case of osteogenesis imperfecta presented with vomiting, decreased oral intake followed by confusion. At presentation he was found to have signs of hypogonadism with severe hyponatremia. The hyponatremia responded to intravenous steroid replacement . Read More

J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):559-561

Department of ENT, Ayub Teaching Hospital, Abbottabad, Pakistan.

Background: Both Total and Subtotal Thyroidectomy are correct treatment options for symptomatic Euthyroid Multinodular Goitre. The choice depends upon surgeon's preference due to consideration of disadvantages like permanent hypothyroidism in Total Thyroidectomy and high chances of recurrence in Subtotal Thyroidectomy. Many surgeons believe that there is a higher incidence of Recurrent Laryngeal nerve injury in Total Thyroidectomy which affects their choice of surgery. Read More

BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.

Department of Diabetes and Endocrinology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire, UK.

A 62-year-old Caucasian woman presented with hypothyroid symptoms and biochemical thyrotoxic picture. Previously, she underwent right-sided subtotal thyroidectomy and left partial thyroid lobectomy for thyroid lumps, and treated with thyroxine replacement for hypothyroidism. Although there were no significant findings on clinical examination, investigations confirmed thyrotoxicosis with positive autoimmunity against thyroid glandâ€"all in line with a diagnosis of Graves’ hyperthyroidism. Read More

Clin Endocrinol (Oxf) 2017 Jul 14. Epub 2017 Jul 14.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province, People's Republic of China.

Context: The prevalence of thyroid disease in China is on the rise and this could be partly associated with excessive iodine intake in some individuals; therefore, increased attention is being paid to individual iodine status. However, current indices are not appropriate for evaluating individual iodine status.

Objective: To evaluate the association between serum iodine and urinary iodine (UI), as well as thyroid diseases and provide an excellent base for future individual iodine status assessment. Read More

Sci Rep 2017 Jul 13;7(1):5329. Epub 2017 Jul 13.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.

The sodium/iodide symporter (NIS) mediates active iodide (I(-)) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due to I(-) transport defect (ITD). ITD is a rare autosomal disorder that, if not treated promptly in infancy, can cause mental retardation, as the TH decrease results in improper development of the nervous system. Read More

Clin J Am Soc Nephrol 2017 Jul 13. Epub 2017 Jul 13.

Institute for Clinical and Translational Science, University of California, Irvine, California.

Background And Objectives: In the general population, there is increasing recognition of the effect of thyroid function on patient-centered outcomes, including health-related quality of life and depression. Although hypothyroidism is highly prevalent in hemodialysis patients, it is unknown whether thyroid status is a risk factor for impaired health-related quality of life or mental health in this population.

Design, Setting, Participants, & Measurements: We examined the association of thyroid status, defined by serum thyrotropin, with health-related quality of life and depressive symptoms over time in a prospective cohort of 450 patients on hemodialysis from 17 outpatient dialysis facilities from May of 2013 to May of 2015 who underwent protocolized thyrotropin testing, Short-Form 36 surveys, and Beck Depression Inventory-II questionnaires every 6 months. Read More

Am J Perinatol 2017 Jul 13. Epub 2017 Jul 13.

Carnegie Imaging for Women, PLLC, Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, Maternal Fetal Medicine Associates, PLLC New York, New York.

Endocrine 2017 Jul 13. Epub 2017 Jul 13.

Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

Medicine (Baltimore) 2017 Jul;96(28):e7482

aDepartment of Neurology bDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University Changwon Hospital cDepartment of Nephrology dDepartment of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Korea.

Patients with drug-susceptible tuberculosis (TB) show good tolerance of the medications used and have few side effects. However, medications used to treat multidrug-resistant tuberculosis (MDR-TB) have many known side effects. Here, we studied the occurrence of side effects due to treatment of patients with MDR-TB. Read More

Thyroid 2017 Jul 12. Epub 2017 Jul 12.

University of Ulsan, Internal Medicine , 88, Olympic-ro 43-gil, Songpa-gu , Seoul, Korea, Republic of , 138-736 ;

Background: Thyroid-stimulating hormone (TSH) suppression has improved the clinical outcomes of patients with differentiated thyroid cancer (DTC). However, the efficacy of TSH suppressive therapy (TST) is unclear in patients with low-risk DTC. We aimed to evaluate the efficacy of TST and optimal TSH levels of patients with low-risk DTC. Read More

Autoimmun Rev 2017 Jul 8. Epub 2017 Jul 8.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address:

Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive patients with NSV and AT (NSV+AT), in 50 sex- and age-matched controls without AT (control 1) and in 40 sex- and age-matched patients with AT without NSV (control 2). Read More

Zhongguo Dang Dai Er Ke Za Zhi 2017 Jul;19(7):741-747

Department of Pediatrics, First People's Hospital of Yunnan Province, Kunming 650032, China.

Objective: To observe the effects of initial doses and treatment timing of levothyroxine (L-T4) on the clinical efficacy in children with congenital hypothyroidism (CH).

Methods: This study included 98 children who had an abnormal level of thyroid stimulating hormone (TSH) in neonatal screening in four regions of Yunnan Province and who finally had a confirmed diagnosis of CH. They received treatment with L-T4 and were divided into standard dose group (10-15 μg/kg per day) and low dose group (<10 μg/kg per day) by the therapeutic dose of L-T4. Read More

Int J Vitam Nutr Res 2017 Jul 12:1-9. Epub 2017 Jul 12.

1 Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.

The relationship between Hashimoto's thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto's thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto's thyroiditis and 43 healthy individuals. Read More

Am J Med Genet A 2017 Jul 11. Epub 2017 Jul 11.

Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.

We report two patients with sagittal craniosynostosis, hypoplastic male genitalia, agenesis of the corpus callosum, thyroid abnormalities, and dysmorphic features which include short palpebral fissures and retrognathia. The clinical presentation of both patients was initially thought to be suggestive of Lin-Gettig syndrome (LGS), a multiple malformation syndrome associated with craniosynostosis that was initially reported in two brothers in 1990, with a third patient reported in 2003. Our first patient was subsequently found through exome sequencing to have a de novo mutation in KAT6B, c. Read More

Australas J Dermatol 2017 Jul 11. Epub 2017 Jul 11.

School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.

Background/objectives: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP. Read More

J Endocrinol Invest 2017 Jul 10. Epub 2017 Jul 10.

Division of Endocrinology, Queens Hospital Center, Icahn School of Medicine, Jamaica, NY, USA.

There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients with unusual thyroxine needs is to escalate the dose of levothyroxine until targeted TSH levels are achieved. Read More

Neuropsychiatr Dis Treat 2017 23;13:1647-1653. Epub 2017 Jun 23.

Department of Pharmacy, Hefei Fourth People's Hospital, Hefei, People's Republic of China.

Despite the increasing amount of evidence suggesting a relationship between depression and subclinical hypothyroidism (SCH), the exact mechanism underlying this relationship remains unclear. The main purpose of this study was to investigate the roles of plasma Nesfatin-1 levels and dysfunction of the hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes in the comorbidity of depression and SCH. Dysfunctions of the HPA and HPT axes were detected by measuring plasma corticosterone and thyroid-stimulating hormone (TSH) concentrations, respectively. Read More

Eur J Endocrinol 2017 Jul 10. Epub 2017 Jul 10.

G Van Vliet, Peditarics, Ste-Justine Hospital, Montreal, H3T 1C5, Canada.

When newborn screening (NBS) for congenital hypothyroidism (CH) using thyroid stimulating hormone (TSH) as a primary screening test was introduced, typical TSH screening cutoffs were 20 to 50 mU/L of whole blood. Over the years, lowering of TSH cutoffs has contributed to an increased prevalence of detected CH. However, a consensus on the benefit deriving from lowering TSH cutoffs at screening is lacking. Read More

Oncol Lett 2017 Jul 19;14(1):1129-1132. Epub 2017 May 19.

Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan, R.O.C.

A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. Read More