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    1 OF 826

    Colonic Perforation: A Medical Complication.
    Prague Med Rep 2017 ;118(2-3):100-104
    Wye Valley NHS Trust, Hereford, United Kingdom.
    Hypothyroidism is a common comorbidity that on acute presentation is often overlooked. It can be an easily managed condition; however non-compliance can have severe consequences. In the presented case it was requirement for emergency surgery that resulted in stoma formation. Read More

    Van Wyk and Grumbach Syndrome: An Unusual Presentation of Hypothyroism.
    Mymensingh Med J 2017 Jul;26(3):667-670
    Dr Palash Kumar Chanda, DEM Student, Department of Endocrinology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.
    An 18 years-old-girl presented one and half years back with the complaints of short stature, retarded growth, and menorrhagia with sudden severe lower abdominal pain; was diagnosed as bilateral ovarian cysts and underwent bilateral ovarian cystectomy. Later on she was incidentally diagnosed as a case of hypothyroidism when she had been experiencing slowly enlarging left lower abdominal mass with dull ache for the 5 month and then was transferred to the department of Endocrinology for further evaluation. Detailed work up revealed her short stature with obesity, delayed bone age and other features of hypothyroidism which was confirmed by thyroid function testing. Read More

    Frequency, Distribution of Congenital Anomaly and Associated Maternal Risk Factors.
    Mymensingh Med J 2017 Jul;26(3):658-666
    Dr Kaniz Fatema, Assistant Professor, Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
    This study was done to find out the maternal risk factors associated with congenital anomaly. This cross-sectional observational study was carried out in the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh from January 2011 to December 2011. During this study period 78 patients had pregnancy with congenital anomaly and delivered in the Department of Obstetrics and Gynaecology. Read More

    Role of Microalbuminuria in Predicting Cardiovascular Mortality in Individuals With Subclinical Hypothyroidism.
    Am J Med Sci 2017 Sep 13;354(3):285-290. Epub 2017 May 13.
    Wayne State University-Detroit Medical Center, Detroit, Michigan. Electronic address:
    Purpose: Studies suggest that subclinical hypothyroidism (SCH) is related to cardiovascular mortality (CVM). We explored the role of microalbuminuria (MIA) as a predictor of long-term CVM in population with and without SCH with normal kidney function.

    Materials And Methods: We examined the National Health and Nutrition Education Survey - III database (n = 6,812). Read More

    Thyroid stimulating hormone, anti-thyroid antibodies and pregnancy outcomes.
    Am J Obstet Gynecol 2017 Sep 13. Epub 2017 Sep 13.
    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B03, Rockville, MD, 20852, United States. Electronic address:
    Background: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications.

    Objective: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. Read More

    Evaluation of neurodevelopment of children with congenital hypothyroidism by the Denver Developmental Screening Test.
    J Pediatr Endocrinol Metab 2017 Sep 16. Epub 2017 Sep 16.
    .
    Background: Thyroid hormones are essential for growth and brain development in childhood. Although congenital hypothyroidism (CH) is the most common reason for mental retardation, normal neurological development can be achieved through early and effective treatment. The aim of the present study was to evaluate the neurological development of CH patients aged 24-56 months. Read More

    Concomitant diseases and their effect on disease prognosis in Meniere's disease: diabetes mellitus identified as a negative prognostic factor.
    Acta Otolaryngol 2017 Sep 15:1-5. Epub 2017 Sep 15.
    a Faculty of Biochemistry and Molecular Medicine , University of Oulu , Oulu , Finland.
    Objective: To study comorbidities and their effect on the disease progression in Meniere's disease (MD).

    Methods: Retrospective study on 350 definite MD patients diagnosed according to AAO-HNS 1995 criteria using hospital records and postal questionnaire.

    Results: The prevalence of migraine, hypothyroidism, allergies, coronary heart disease and autoimmune diseases was more common in MD patients than reported in the general population of Finland. Read More

    Subclinical hypothyroidism: Is it important in intracytoplasmic sperm injection cycles?
    Turk J Obstet Gynecol 2017 Jun 15;14(2):100-105. Epub 2017 Jun 15.
    University of Health Sciences, Zeynep Kamil Maternity and Children's Health Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.
    Objective: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women.

    Materials And Methods: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Read More

    Randomized Trial Comparing Two Algorithms for Levothyroxine Dose Adjustment in Pregnant Women With Primary Hypothyroidism.
    J Clin Endocrinol Metab 2017 Sep;102(9):3499-3507
    Department of Medicine, Endocrine Division, MedStar Washington Hospital Center, Washington, DC 20010.
    Context: Regulation of maternal thyroid hormones during pregnancy is crucial for optimal maternal and fetal outcomes. There are no specific guidelines addressing maternal levothyroxine (LT4) dose adjustments throughout pregnancy.

    Objective: To compare two LT4 dose-adjustment algorithms in hypothyroid pregnant women. Read More

    Paediatric nuclear medicine imaging.
    Br Med Bull 2017 Sep;123(1):127-148
    Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
    Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Read More

    Detecting Congenital Central Hypothyroidism by Newborn Screening: Difficulty in Distinguishing from Congenital Thyroxine-Binding Globulin Deficiency.
    Horm Res Paediatr 2017 Sep 14. Epub 2017 Sep 14.
    Background/aims: Congenital central hypothyroidism (CH-C) can be detected on newborn screening (NBS) by programs using thyroxine (T4)-reflex thyroid-stimulating hormone (TSH) test approach. CH-C must be distinguished from T4-binding globulin (TBG) deficiency. We sought to determine whether thyroid function tests reliably separate CH-C from TBG deficiency. Read More

    Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene.
    PLoS Genet 2017 Sep 14;13(9):e1006991. Epub 2017 Sep 14.
    Laboratory of Molecular Biology, the Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
    Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1PV/+ mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using Thra1PV/+ mice, we explored how the TRα1PV mutant acted to cause abnormalities in erythropoiesis. Read More

    Drug interactions in users of tablet vs. oral liquid levothyroxine formulations: a real-world evidence study in primary care.
    Endocrine 2017 Sep 14. Epub 2017 Sep 14.
    Health Search, Italian College of General Practitioners and Primary Care, Florence, Italy.
    Purpose: Several medications may interact with levothyroxine (LT4) intestinal absorption or metabolism, thus reducing its bioavailability. We investigated the variability of thyroid stimulating hormone (TSH) levels and prescribed daily dosages (PDDs) of LT4 before and during potential drug-drug interactions (DDIs) in users of tablets vs. oral liquid LT4 formulations. Read More

    Hashimoto's Encephalitis: Rare Manifestation of Hypothyroidism.
    Int J Appl Basic Med Res 2017 Jul-Sep;7(3):193-195
    Department of Medicine, King George's Medical College, Lucknow, Uttar Pradesh, India.
    Hashimoto's encephalitis is a rare, heterogeneous and completely treatable form of neuroendocrine disorder manifesting with seizures, stroke-like episodes, encephalopathy, dementia and variable neuropsychiatric manifestations. It is generally associated with a background of Hashimoto's Thyroiditis, and the patient has high titers of antithyroid antibodies, especially antithyroid peroxidase antibodies. This entity responds dramatically to corticosteroids, hence should be always considered and excluded while treating a patient with encephalopathy in the background of a thyroid disease. Read More

    Use of thyroid-stimulating hormone tests for identifying primary hypothyroidism in family medicine patients.
    Can Fam Physician 2017 Sep;63(9):e389-e394
    Completing his family medicine residency with the Southlake Academic Family Health Team, Southlake Regional Health Centre, in the DFCM at the University of Toronto.
    Objective: To assess the use of thyroid-stimulating hormone (TSH) tests for identifying primary hypothyroidism in 2 academic family medicine settings.

    Design: Descriptive study involving a retrospective electronic chart review of family medicine patients who underwent TSH testing.

    Setting: Two academic family practice sites: one site is within a tertiary hospital in Toronto, Ont, and the other is within a community hospital in Newmarket, Ont. Read More

    Evaluation of Metabolic Syndrome and Related Factors in Children Affected by Acute Lymphoblastic Leukemia.
    Indian J Med Paediatr Oncol 2017 Apr-Jun;38(2):97-102
    Department of Pediatrics, Division of Pediatric Endocrinology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Introduction: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. Read More

    Pilot Neonatal Screening Program for Central Congenital Hypothyroidism: Evidence of Significant Detection.
    Horm Res Paediatr 2017 Sep 12. Epub 2017 Sep 12.
    Fundación de Endocrinología Infantil, Buenos Aires, Argentina.
    Background/aim: Congenital hypothyroidism (CH) is a heterogeneous entity. Neonatal screening programs based on thyrotropin (TSH) determination allow primary CH diagnosis but miss central CH (CCH). CCH causes morbidity, alerts to other pituitary deficiencies, and is more prevalent than previously thought. Read More

    The effect of short-term treatment with lithium carbonate on the outcome of radioiodine therapy in patients with long-lasting Graves' hyperthyroidism.
    Ann Nucl Med 2017 Sep 11. Epub 2017 Sep 11.
    Center of Nuclear Medicine and Clinical Center of Niš, University of Niš, Faculty of Medicine, bul. Dr Zoran Đinđić 48, 18000, Niš, Serbia.
    Objective: The outcome of radioiodine therapy (RIT) in Graves' hyperthyroidism (GH) mainly depends on radioiodine ((131)I) uptake and the effective half-life of (131)I in the gland. Studies have shown that lithium carbonate (LiCO3) enhances the (131)I half-life and increases the applied thyroid radiation dose without affecting the thyroid (131)I uptake. We investigated the effect of short-term treatment with LiCO3 on the outcome of RIT in patients with long-lasting GH, its influence on the thyroid hormones levels 7 days after RIT, and possible side effects. Read More

    POEMS Syndrome with Biclonal Gammopathy: A Rare Association.
    J Clin Diagn Res 2017 Jul 1;11(7):XD12-XD13. Epub 2017 Jul 1.
    Consultant, Department of Transfusion Medicine, The Mission Hospital, Durgapur, West Bengal, India.
    Polyneuropathy, Organomegaly, Endocrinopathy, M protein and Skin changes (POEMS) syndrome is rare plasma cell dyscrasia with multisystem involvement. The name comes from the five characteristic features: Polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes. The presence of biclonal M band is a rare manifestation. Read More

    Frequent Occurrence of Faulty Practices, Misconceptions and Lack of Knowledge among Hypothyroid Patients.
    J Clin Diagn Res 2017 Jul 1;11(7):OC15-OC20. Epub 2017 Jul 1.
    Professor, Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India.
    Introduction: Hypothyroidism is a common endocrine disorder with a reported prevalence of 4%-10%. Previous studies have reported significant gaps in the basic knowledge about the condition in hypothyroid patients. It has also been observed that faulty practices prevail among these patients. Read More

    Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441).
    J Endocrinol Invest 2017 Sep 9. Epub 2017 Sep 9.
    The Department of Surgery and Cancer, Imperial College London, 10th Floor Queen Elizabeth the Queen Mother (QEQM) Building, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
    Background: The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art.

    Purpose: The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these requires pathological consideration. Read More

    Predictive Factors of Nivolumab-induced Hypothyroidism in Patients with Non-small Cell Lung Cancer.
    In Vivo 2017 Sep-Oct;31(5):1035-1039
    Department of Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
    Background/aim: Although immune checkpoint inhibitors play an important role in the therapy of lung cancer, they are associated with various immune-related adverse events and predictive factors of them are unclear. In this study, we investigated predictive factors of nivolumab-induced hypothyroidism which is one of the adverse events in patients with lung cancer.

    Patients And Methods: Patients with non-small-cell lung cancer who were administered nivolumab at our hospital between December 2015 and May 2016 were retrospectively enrolled. Read More

    TSH cut off point based on depression in hypothyroid patients.
    BMC Psychiatry 2017 Sep 7;17(1):327. Epub 2017 Sep 7.
    Department of Internal Medicine, School of Medicine, Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.
    Background: The prevalence of depressive symptoms in hypothyroidism is high. Considering that hypothyroidism and depression share some clinical features, some researchers use the "brain hypothyroidism" hypothesis to explain the pathogenesis of depression. We aimed to detect a new TSH cut-off value in hypothyroidism based on depression symptoms. Read More

    Characteristics of nerve conduction studies in carpal tunnel syndrome.
    Neurol India 2017 Sep-Oct;65(5):1013-1016
    Department of Neurology, Government Medical College, Kota, Rajasthan, India.
    Background: Numerous nerve conduction tests are used for the electrodiagnosis of carpal tunnel syndrome (CTS), with a wide range of sensitivity and specificity reported for each test in clinical studies.

    Aims: The purpose of this study was to compare the diagnostic accuracy of various nerve conduction tests and determine the properties of the most accurate test.

    Settings And Design: A prospective observational case control study. Read More

    Thyroid Association Ophthalmopathy in Hashimoto's Thyroiditis: a Case Report.
    Maedica (Buchar) 2017 Jan;12(1):65-67
    Assistant Professor, Department of Pathology, Pt.B.D.Sharma PGIMS, Rohtak, India.
    Thyroid associated ophthalmopathy is a constellation of symptoms caused by an autoimmune process involving the orbital tissue. It is common in hyperthyroid patients due to Graves' disease and also reported in euthyroid and hypothyroid Graves' patients with positive thyroid receptor antibodies. But in Hashimoto's thyroiditis, thyroid associated ophthalmopathy is a rarely reported and poorly understood entity. Read More

    Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis.
    Nagoya J Med Sci 2017 Aug;79(3):331-338
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2. Read More

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain.
    Elife 2017 Sep 6;6. Epub 2017 Sep 6.
    CNRS UMR 7221, Muséum d'Histoire Naturelle, Sorbonne Universités, Paris, France.
    In the adult brain, both neurons and oligodendrocytes can be generated from neural stem cells located within the Sub-Ventricular Zone (SVZ). Physiological signals regulating neuronal versus glial fate are largely unknown. Here we report that a thyroid hormone (T3)-free window, with or without a demyelinating insult, provides a favorable environment for SVZ-derived oligodendrocyte progenitor generation. Read More

    The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans.
    J Korean Med Sci 2017 Oct;32(10):1626-1632
    Department of Biomedical Sciences, Inha University College of Medicine, Incheon, Korea.
    Subclinical hyperthyroidism and subclinical hypothyroidism are characterized by abnormal thyroid stimulating hormone (TSH) with normal free thyroxine. Subclinical thyroid diseases, to date, have received less attention compared with other thyroid diseases since they are asymptomatic. This study aimed to verify the association between subclinical thyroid diseases and cardiovascular diseases (CVDs) risk score in the Korean population. Read More

    Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies.
    JAMA Neurol 2017 Sep 5. Epub 2017 Sep 5.
    Department of Neurology, Mayo Clinic, Rochester, Minnesota.
    Importance: Neurological complications are an increasingly recognized consequence of the use of anti-programmed death 1 (PD-1) antibodies in the treatment of solid-organ tumors, with an estimated frequency of 4.2%. To date, the clinical spectrum and optimum treatment approach are not established. Read More

    Hybrid SPECT/CT Helps Characterization and Localization of a Dual Thyroid Ectopia.
    Clin Nucl Med 2017 Sep 1. Epub 2017 Sep 1.
    From the *Nuclear Medicine Unit, South Egypt Cancer Institute, and †Nuclear Medicine Unit and ‡Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
    The presence of ectopic thyroid tissue in 2 or more different sites is rare. A 12-year-old girl presented with midline anterior neck swelling in the infrahyoid region with subclinical hypothyroidism. Thyroid scanning with Tc-pertechnetate was performed, and SPECT/CT was ordered for further evaluation. Read More

    [Subclinical hypothyroidism and endocrine metabolic characteristics in women with polycystic ovary syndrome].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):940-946
    Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To explore associations of subclinical hypothyroidism (SCH) with endocrine metabolic characteristics in women with polycystic ovary syndrome (PCOS).
 Methods: A total of 321 women who were newly diagnosed as PCOS were recruited from two endocrine outpatient clinics. The diagnosis of PCOS was established according to the 2003 Rotterdam consensus criteria. Read More

    Pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism in a patient with selective L-thyroxine malabsorption.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):243-247. Epub 2017 Aug 5.
    Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324, Rome 00161, Italy, Italy.
    We present the case of a 29-year-old woman who developed a severe hypothyroidism induced by a thyroxine malabsorption and a secondary pituitary hyperplasia. We performed thyroxine absorption tests to diagnose the malabsorption and to evaluate the best therapeutic intervention. Once assessed a correct therapy lowering TSH, we observed the regression of pituitary mass confirming our diagnosis of secondary pituitary hyperplasia. Read More

    Thyroidectomy stimulates glucagon-like peptide-1 secretion and attenuates hepatic steatosis in high-fat fed rats.
    Biochem Biophys Res Commun 2017 Sep 1. Epub 2017 Sep 1.
    Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea. Electronic address:
    Thyroid hormones (THs) as a therapeutic intervention to treat obesity has been tried but the effect of THs on body weight and the mechanistic details of which are far from clear. This study was designed to determine and elucidate the mechanistic details of metabolic action of THs in high-fat diet (HFD) fed Sprague Dawley (SD) rats. Rats were made surgically hypothyroid (thyroidectomy, Thx). Read More

    Soy isoflavones inducing overt hypothyroidism in a patient with chronic lymphocytic thyroiditis: a case report.
    J Med Case Rep 2017 Sep 5;11(1):253. Epub 2017 Sep 5.
    Department of Internal Medicine, Saiyu Soka Hospital, 1-7-22 Matsubara, Soka City, Saitama, 344-0041, Japan.
    Background: Many people have thyroid conditions that make them susceptible to hypothyroidism. If the foods they eat may interfere with the production of thyroid hormone, which can lead to development of serious hypothyroidism. The danger of health drinks should always be noted. Read More

    Primary Care Provider Management of Congenital Hypothyroidism Identified Through Newborn Screening.
    Ann Thyroid Res 2017 18;3(1):95-101. Epub 2017 Apr 18.
    California Department of Public Health, Genetic Disease Screening Program, USA.
    Objective: To assess Primary Congenital Hypothyroidism (CH) management patterns and feasibility of providing long-term care for patients with CH identified through newborn screening by Primary Care Providers (PCPs) in California and Hawaii.

    Study Design: A survey was mailed to all physicians (N=823) listed as the referral doctor for confirmed patients with CH identified through newborn screening programs in both states between 01/01/2009-12/31/2013. Information was collected on CH management patterns, barriers to providing care, and knowledge on CH treatment. Read More

    Nonalcoholic Fatty Liver Disease Is Not Associated with Thyroid Hormone Levels and Hypothyroidism: A Systematic Review and Meta-Analysis.
    Eur Thyroid J 2017 Jul 21;6(4):208-215. Epub 2017 Jan 21.
    Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA.
    Background: Whether hypothyroidism is related to nonalcoholic fatty liver disease (NAFLD) is unclear. Thyroid dysfunction is closely related with components of metabolic syndrome. Given the hepatic manifestation of metabolic syndrome, several studies have investigated the association between NAFLD and thyroid dysfunction and have demonstrated inconsistent results. Read More

    TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).
    Eur Thyroid J 2017 Jul 4;6(4):197-207. Epub 2017 Apr 4.
    Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, UK.
    Background: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome.

    Objectives: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).

    Methods: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15. Read More

    Should Subclinical Hypothyroidism Be an Exclusion Criterion for the Diagnosis of Polycystic Ovary Syndrome?
    J Reprod Infertil 2017 Apr-Jun;18(2):242-250
    University of Adelaide, Robinson Research Institute and Fertility SA, Adelaide, Australia.
    Background: The purpose of the study was to examine whether patients with subclinical hypothyroidism (SCH) should be excluded before making a diagnosis of polycystic ovary syndrome (PCOS).

    Methods: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Read More

    Mild thyroid peroxidase deficiency caused by TPO mutations with residual activity: Correlation between clinical phenotypes and enzymatic activity.
    Endocr J 2017 Sep 1. Epub 2017 Sep 1.
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan.
    Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). More than 100 patients have been published, and the patients have been diagnosed mostly in the frame of newborn screening (NBS) programs. Correlation between clinical phenotypes and TPO activity remains unclear. Read More

    [Fine-tuning of antithrombotic therapy in patients with non-valvular atrial fibrillation. The AFINVA register].
    Aten Primaria 2017 Aug 31. Epub 2017 Aug 31.
    Servicio de Cardiología, Hospital Universitario Dr Peset, Valencia, España.
    Objective: To determine whether antithrombotic treatment (ATT) in patients with non-valvular atrial fibrillation in a health area complies with the recommendations of current clinical guidelines.

    Design: Prospective observational study.

    Location: Primary Health Care Centres and Cardiology Department of a Health Department of the Valencian Community, Spain. Read More

    Biological aspects and candidate biomarkers for rapid-cycling in bipolar disorder: A systematic review.
    Psychiatry Res 2017 Aug 24. Epub 2017 Aug 24.
    Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.
    Rapid-cycling bipolar disorder represents a frequent severe subtype of illness which has been associated with poor response to pharmacological treatment. Aim of the present article is to provide an updated review of biological markers associated with rapid-cycling bipolar disorder. A research in the main database sources has been conducted to identify relevant papers about the topic. Read More

    [Hypothyroidism in adults in a basic health area].
    Semergen 2017 Aug 29. Epub 2017 Aug 29.
    Unidad Docente de Medicina Familiar y Comunitaria de Córdoba, Distrito Sanitario Córdoba y Guadalquivir, Córdoba, España.
    Introduction: The objective of the present study is to study the prevalence, as well as the clinical and epidemiological characteristics of hypothyroid disease in adults using the computerised clinical records.

    Material And Methods: Observational, descriptive and cross-sectional study. The target population was the patients of the health centres of Lucena I and II (Córdoba). Read More

    Unraveling hypothyroidism in AL amyloidosis: Authors' reply.
    J Intern Med 2017 Sep 1. Epub 2017 Sep 1.
    Division of Hematology, Mayo Clinic, Rochester, MN.
    We read with interest the insightful comments by Benvenga and Guarneri (1) on our recently published paper which assessed the high prevalence of hypothyroidism among patients with immunoglobulin light chain (AL) amyloidosis.(2) The paper was the first research paper to address this topic in AL amyloidosis, so we appreciate any insights that can expand the understanding of this complex disease. Amyloidosis is an extremely heterogeneous disorder, and therefore various pathogenic mechanisms may play a role in organ dysfunction. Read More

    Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
    J Biol Chem 2017 Aug 31. Epub 2017 Aug 31.
    The University of Texas at Austin, United States;
    SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in blood and brain, and develop neurotoxicity. Read More

    Novel Stat1 Mutation Disrupts Small Ubiquitin-Related Modifier (Sumo) Conjugation Causing Gain Of Function.
    J Allergy Clin Immunol 2017 Aug 28. Epub 2017 Aug 28.
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIAID, National Institutes of Health, NIH, Bethesda, MD 20892-1684.
    Background: Sumoylation is a post-translational reversible modification of cellular proteins by the conjugation of SUMO (small ubiquitin-related modifier) and comprises an important regulator of protein function.

    Objective: To characterize the molecular mechanism of a novel mutation at the SUMO motif on STAT1.

    Methods: STAT1 sequencing and functional characterization were performed in transfection experiments using immunoblotting and immunoprecipitation in STAT1-deficient cell lines. Read More

    Unstable thyroid function in older adults is caused by alterations in both thyroid and pituitary physiology and associated with increased mortality.
    Thyroid 2017 Aug 30. Epub 2017 Aug 30.
    National Institutes of Health, National Institue of Aging, Baltimore, Maryland, United States ;
    Background: Average thyrotropin (TSH) levels are known to be higher in older adults when measured in cross-sectional populations. Possible etiologies include differential survival, neutral aging changes, or increased disease prevalence at older ages. This study aimed to elucidate the mechanisms underlying changing thyroid function during aging, and to determine the association of changes with survival, by analyzing the individual thyroid axis over time. Read More

    Routine serum thyroid-stimulating hormone testing-optimizing pre-conception health or generating toxic knowledge?
    Hum Reprod 2017 Sep;32(9):1779-1785
    School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
    Monitoring subclinical hypothyroidism (SCH) in women is believed to be important in terms of preventing overt hypothyroidism and optimizing the health and cognitive development of their children. Current systematic reviews have suggested an association between maternal SCH and adverse obstetric and neonatal outcomes. However, initiating the administration of thyroxine during pregnancy has failed to demonstrate appreciable health benefits. Read More

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