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    Congenital Hypothyroidism: Role of Nuclear Medicine.
    Semin Nucl Med 2017 Mar 16;47(2):135-142. Epub 2016 Dec 16.
    Service de Médecine Nucléaire Pédiatrique, Hôpital d'Enfants Armand Trousseau, Paris, France; UPMC Univ Paris 06, Biophysique, Paris, France. Electronic address:
    Thyroid scintigraphy holds a key place in the etiologic workup of neonatal hypothyroidism. Routine screening for this disorder in maternity hospitals in industrialized countries, for nearly 40 years, has permitted early treatment and thereby helped to prevent its physical and mental complications. Neonatal hypothyroidism affects approximately 1 in 3000 births. Read More

    Comparison of endoscopic and conventional open thyroidectomy for graves' disease: A meta-analysis.
    Int J Surg 2017 Feb 21. Epub 2017 Feb 21.
    Department of Surgery, Jinan University Institute for Minimally Invasive Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address:
    Background: Despite experience with the use of endoscopic surgical technology, there is controversy over the role of endoscopic thyroidectomy (ET) for Graves' disease (GD). This study aimed to conduct a meta-analysis to evaluate the cosmetic and safety outcomes of ET versus conventional open thyroidectomy (OT) for GD with respect to short-term consequences.

    Methods: We searched the following English language databases (Ovid MEDLINE, ISI Web of Science, and the Cochrane Library), and Chinese language databases (CNKI, CBMdisc, and SinoMed) between January 1996 and November 2015. Read More

    Risk of endocrine adverse events in cancer patients treated with PD-1 inhibitors: a systematic review and meta-analysis.
    Immunotherapy 2017 Mar;9(3):261-272
    Department of Radiation Oncology, Affiliated Hospital of Hebei University, 212 East Yuhua Road, Baoding 071000, Hebei, P R China.
    Aim: We conducted this meta-analysis to investigate the overall incidence and risk of endocrine complications in cancer patients treated with PD-1 inhibitors.

    Methods: Pubmed, Embase and oncology conference proceedings were searched for relevant studies.

    Results: In comparison with chemotherapy or everolimus or cetuximab control, PD-1 inhibitors significantly increased the risk of all grade hypothyroidism (relative risk: 6. Read More

    Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.
    Sci Rep 2017 Feb 23;7:43396. Epub 2017 Feb 23.
    State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Tianjin Key Laboratory of Protein Sciences and College of Life Sciences, Nankai University, Tianjin 300071, China.
    Thyroid is a one of the most important endocrine organs. Understanding the molecular mechanism underlying thyroid development and function, as well as thyroid diseases, is beneficial for the clinical treatment of thyroid diseases and tumors. Through genetic linkage analysis and exome sequencing, we previously identified an uncharacterized gene C14orf93 (RTFC, mouse homolog: 4931414P19Rik) as a novel susceptibility gene for familial non-medullary thyroid carcinoma, and demonstrated its function in promoting thyroid tumor. Read More

    RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis.
    Eur J Clin Invest 2017 Feb 22. Epub 2017 Feb 22.
    Endocrine Unit, Dept Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
    Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of the present study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel we studied oxidative stress levels. Read More

    Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism.
    Arch Endocrinol Metab 2017 Feb 13. Epub 2017 Feb 13.
    Disciplina de Endocrinologia, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brasil.
    Objectives: To describe the findings of thyroid ultrasonography (T-US), its contribution to diagnose congenital hypothyroidism (CH) and the best time to perform it.

    Subjects And Methods: Forty-four patients with CH were invited to undergo T-US and 41 accepted. Age ranged from 2 months to 45 years; 23 patients were females. Read More

    Outcomes from the first multidrug-resistant tuberculosis programme in Kenya.
    Int J Tuberc Lung Dis 2017 Mar;21(3):314-319
    Médecins Sans Frontières, Paris, France.
    Setting: In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya.

    Objective: To describe patients' treatment outcomes and adverse events.

    Design: A retrospective case note review of patients started on MDR-TB treatment at two Médecins Sans Frontières-supported sites and the national referral hospital of Kenya was undertaken. Read More

    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study.
    World J Gastroenterol 2017 Feb;23(5):842-852
    Thorsten Brechmann, Andre Sperlbaum, Wolff Schmiegel, Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, 44789 Bochum, Germany.
    Aim: To identify a set of contributors, and weight and rank them on a pathophysiological basis.

    Methods: Patients who have undergone a lactulose or glucose hydrogen breath test to rule out small intestinal bacterial overgrowth (SIBO) for various clinical symptoms, including diarrhoea, weight loss, abdominal pain, cramping or bloating, were seen as eligible for inclusion in a retrospective single-centre study. Clinical data such as co-morbidities, medication, laboratory parameters and other possible risk factors have been identified from the electronic data system. Read More

    Myotoxicity of statins: Mechanism of action.
    Pharmacol Ther 2017 Feb 14. Epub 2017 Feb 14.
    Clinique de Prévention Cardiovasculaire, Institut de Recherche Clinique de Montréal, Canada; Département de nutrition, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada.
    Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia; however, they cause frequent undesirable side effects. The incidence of statin-induced myotoxicity (SIM) is presented by 7 to 29% of patients, depending upon the report. SIM may develop in presence of abnormally high concentrations of statins in the myocyte and/or in presence of muscular conditions that may predispose to SIM. Read More

    Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
    Lancet Oncol 2017 Feb 17. Epub 2017 Feb 17.
    The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Background: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy associated with infection by human papillomavirus (HPV). No consensus treatment approach exists for the treatment of metastatic disease. Because intratumoral HPV oncoproteins upregulate immune checkpoint proteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody nivolumab for patients with metastatic SCCA. Read More

    Exome sequencing identifies SLC26A4, GJB2, SCARB2 and DUOX2 mutations in 2 siblings with Pendred syndrome in a Malaysian family.
    Orphanet J Rare Dis 2017 Feb 21;12(1):40. Epub 2017 Feb 21.
    UKM Medical Molecular Biology Institute (UMBI), Chancellor Tuanku Muhriz Hospital, UKM Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.
    Background: Pendred syndrome (PDS, MIM #274600) is an autosomal recessive disorder characterized by congenital sensorineural hearing loss and goiter. In this study, we describing the possible PDS causal mutations in a Malaysian family with 2 daughters diagnosed with bilateral hearing loss and hypothyroidism.

    Methods And Results: Whole exome sequencing was performed on 2 sisters with PDS and their unaffected parents. Read More

    Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents.
    Hormones (Athens) 2016 Oct;15(4):500-510
    Dr. Cesar Milstein Hospital, Buenos Aires, Argentina.
    L-thyroxine (LT4) treatment of hypothyroidism, particularly in patients with thyroid- stimulating hormone (TSH) >10mU/L, results in improved lipid profile, as LT4 stimulates low-density lipoprotein cholesterol (LDL-C) degradation and the conversion of cholesterol in bile acids by inducing LDL-receptor and 7 alpha hydroxylase expression, respectively. Statins decrease total cholesterol (TC) and LDL-C mainly by suppressing 3-hydroxy-3-methylglutaryl coenzyme A activity. Therefore, the addition of statins to LT4 treatment, following the reversal of hypothyroidism, acts synergistically and forms a powerful treatment modality in patients with this condition whose serum lipids have not achieved the target. Read More

    Non-HDL-cholesterol and C-reactive protein in children and adolescents with type 1 diabetes.
    J Pediatr Endocrinol Metab 2017 Feb 21. Epub 2017 Feb 21.
    Background: To what extent high sensitivity C-reactive protein (hsCRP) is associated with known cardiovascular risk factors in children with type 1 diabetes (T1D) has not been fully explored.

    Methods: Forty-two T1D children (age: 12+/-1 years) without hypertension, retinopathy, hypothyroidism, albuminuria or other endocrine diseases and 20 controls were studied. Out of the 42 T1D patients studied 57% were prepubertal or early pubertal (Tanner I/II), 38% were pubertal (Tanner III/IV) and 5% post-pubertal (Tanner V). Read More

    J Clin Res Pediatr Endocrinol 2017 Feb 20. Epub 2017 Feb 20.
    Objective: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity but there is limited data regarding MC4R mutations in Turkish subjects. To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents.

    Methods: MC4R was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1-18 years) who presented during a 1-year period. Read More

    Unravelling thyroid dysfunction in rheumatoid arthritis: History matters.
    Int J Rheum Dis 2017 Feb 20. Epub 2017 Feb 20.
    Division of Clinical immunology & Rheumatology, St. John's Medical College, Bangalore, Karnataka, India.
    Aim: Autoimmune thyroid disease (AITD) frequently coexists with other systemic autoimmune conditions such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Due to the overlapping and nonspecific nature of symptoms, it is difficult to clinically uncover thyroidal illnesses in RA patients. This study was conducted to estimate the prevalence of thyroid dysfunction including the presence of anti-thyroid peroxidase (antiTPO) autoantibodies in patients with RA and to analyze symptomatology of thyroid dysfunction in patients diagnosed with RA. Read More

    Occult endocrine dysfunction in patients with cirrhosis of liver.
    J Family Med Prim Care 2016 Jul-Sep;5(3):576-580
    Department of Gastroenterology, Command Hospital, Chandimandir, Panchkula, Haryana, India.
    Background: Liver dysfunction leads to endocrine disturbance due to the alteration in protein metabolism or synthesis. We studied the presence of occult endocrine dysfunction in liver cirrhosis and compared the same with underlying etiology.

    Materials And Methods: We evaluated thirty patients with liver cirrhosis in this cross-sectional, observational study. Read More

    A 2016 clinical practice pattern in the management of primary hypothyroidism among doctors from different clinical specialties in New Delhi.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):165-177
    Department of Endocrinology, Post-Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
    Background: This study aimed to document practices in managing hypothyroidism among doctors in New Delhi, with special focus on subclinical hypothyroidism, pregnancy, and old age, and to compare it with global practices.

    Methods: During an academic program attended by 394 doctors, all participants were given a questionnaire designed based on thyroid practices survey done by Burch et al. to evaluate the practice patterns. Read More

    Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):85-89
    Department of Pediatrics, CSI Hospital, Bengaluru, Karnataka, India.
    Objective: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children.

    Materials And Methods: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter. Forty-three children with confirmed autoimmune thyroiditis served as cases, and 43 children with euthyroid goiter with workup negative for autoimmune thyroiditis and iodine deficiency were enrolled as controls. Read More

    Thyroid profile and autoantibodies in Type 1 diabetes subjects: A perspective from Eastern India.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):45-50
    Department of Endocrinology, Park Clinic, Kolkata, West Bengal, India.
    Context: There has been a rise in the incidence of type 1 diabetes mellitus (T1DM) in India. The prevalence of thyroid autoantibodies and thyroid dysfunction is common in T1DM.

    Aims: The aim of this study is to determine the incidence of thyroid dysfunction and thyroid autoantibodies in T1DM subjects, without any history of thyroid disease, and the prevalence of glutamic acid decarboxylase (GAD) antibody, Islet antigen-2 antibody (IA2), thyroid peroxidase (TPO), and thyroglobulin autoantibodies (Tg-AB) in T1DM subjects. Read More

    Effects of thyroid status on glycated hemoglobin.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):26-30
    Department of Endocrinology and Metabolism, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India.
    Introduction: Glycated hemoglobin (HbA1c) can be altered in different conditions. We hypothesize that HbA1c levels may change due to altered thyroid status, possibly due to changes in red blood cell (RBC) turnover.

    Objectives: The objective of this study was to determine the effects of altered thyroid status on HbA1c levels in individuals without diabetes, with overt hyper- and hypo-thyroidism, and if present, whether such changes in HbA1c are reversed after achieving euthyroid state. Read More

    Septo-optic dysplasia/de Morsier's syndrome.
    Saudi J Anaesth 2017 Jan-Mar;11(1):106-107
    Department of Anesthesia, São João Hospital Centre, Porto, Portugal; Department of Anesthesia, Medical Faculty, Oporto University, Porto, Portugal.
    Septo-optic dysplasia (SOD)/de Morsier's syndrome is characterized by optic nerve hypoplasia, pituitary endocrine dysfunction, and midline brain abnormalities. Hypopituitarism, hypothyroidism, hypogonadism, and adrenal insufficiency can lead to severe hypoglycemia, adrenal crisis, seizures, and sudden death. Anesthetic management of SOD was associated with high perioperative mortality. Read More

    Next-generation sequencing analysis of twelve known causative genes in congenital hypothyroidism.
    Clin Chim Acta 2017 Feb 16;468:76-80. Epub 2017 Feb 16.
    Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, People's Republic of China; GuangXi Center for Birth Defects Research and Prevention, Nanning 530003, People's Republic of China. Electronic address:
    Background: Gene variants have been reported to be associated with congenital hypothyroidism (CH), the purpose of this study was to analyze the mutation spectrum and prevalence of 12 known causative genes (TSHR, PAX8, NKX2.1, NKX2.5, FOXE1, DUOX2, TG, TPO, GLIS3, NIS, SLC26A4 and DEHAL1) in CH in China. Read More

    The Italian Dystonia Registry: rationale, design and preliminary findings.
    Neurol Sci 2017 Feb 18. Epub 2017 Feb 18.
    Department of Neurology and Psychiatry, Neuromed Institute IRCCS, Sapienza University of Rome, Pozzilli, Italy.
    The Italian Dystonia Registry is a multicenter data collection system that will prospectively assess the phenomenology and natural history of adult-onset dystonia and will serve as a basis for future etiological, pathophysiological and therapeutic studies. In the first 6 months of activity, 20 movement disorders Italian centres have adhered to the registry and 664 patients have been recruited. Baseline historical information from this cohort provides the first general overview of adult-onset dystonia in Italy. Read More

    Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats.
    J Endocrinol Invest 2017 Feb 17. Epub 2017 Feb 17.
    Department of Endorinology and Metabolism, The Second Hospital of Anhui Medical University, 678, Furong Road, Hefei, Anhui, 230601, China.
    Objective: To explore the underlying mechanism and treatment of myocardial injury caused by hypothyroidism, we evaluated oxidative stress in serum and myocardial tissue of hypothyroid rats. The effect of levothyroxine (LT4) replacement therapy and vitamin E (VitE) supplementation on oxidative stress-induced injury and apoptosis of myocardial tissue is examined.

    Methods: Male Sprague-Dawley rats were divided into five groups: normal control group, propylthiouracil group (PTU group), LT4 treatment group (PTU + LT4 group), vitamin E treatment group (PTU + VitE group), and combined treatment group (PTU + LT4 + VitE group). Read More

    Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
    Mol Cell Endocrinol 2017 Feb 14. Epub 2017 Feb 14.
    Institute of Endocrinology, Shandong Academy of Clinical Medicine; Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, 544 Jing 4 Rd Jinan, Shangdong 250021, PR China. Electronic address:
    Epidemiological evidence indicates that thyroid stimulating hormone (TSH) is positively correlated with abnormal glucose levels. We previously reported that TSH has direct effects on gluconeogenesis. However, the underlying molecular mechanism remains unclear. Read More

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study.
    BMC Endocr Disord 2017 Feb 17;17(1):10. Epub 2017 Feb 17.
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No154 Anshan Road, Heping District, Tianjin, 300052, China.
    Background: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. Read More

    [Frequency of increased thyrotropin in women with hyperprolactinemia].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S53-S57
    División de Investigación en Salud, Hospital de Ginecoobstetricia 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Hypothyroidism has been associated to hyperprolactinemia. The aim was to establish the frequency of high thyrotropin (TSH) levels in women with hyperprolactinemia.

    Methods: Retrospective, observational, open, and non-controlled study, which included all the non-pregnant women whose prolactin (PRL) and TSH levels were measured between January 1 and December 31, 2014. Read More

    The interrelation between hypothyroidism and glaucoma: a critical review and meta-analyses.
    Acta Ophthalmol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark.
    Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Read More

    The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).

    Objective: We sought to determine the inpatient burden and comorbidities of PAIBD.

    Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Read More

    Nephrotic Syndrome Increases the Need for Levothyroxine Replacement in Patients with Hypothyroidism.
    J Clin Diagn Res 2016 Dec 1;10(12):OC10-OC12. Epub 2016 Dec 1.
    Associate Professor, Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center , Bengaluru, Karnataka, India .
    Introduction: Nephrotic syndrome is a known cause of hypothyroidism; however, its effect on replacement doses of L-thyroxine in patients with primary hypothyroidism is not systematically studied.

    Aim: The aim of the present study was to evaluate the effect of newly diagnosed nephrotic syndrome on the dose of L-thyroxine replacement in previously diagnosed patients with primary hypothyroidism who were on full, stable dose of L-thyroxine replacement for at least one year.

    Materials And Methods: Patients with previously diagnosed primary hypothyroidism on stable and full (≥1. Read More

    Primary hypothyroidism in the community: Lower daily dosages of levothyroxine replacement therapy for Asian patients.
    Medicine (Baltimore) 2017 Feb;96(7):e6145
    aDepartment of Research, SingHealth Polyclinics bDuke NUS Medical School, Singapore cFaculty of Medicine, University of New South Wales, Sydney, Australia dDepartment of Endocrinology, Changi General Hospital, Singapore.
    The goal of treatment in patients with primary hypothyroidism is to attain euthyroidism guided by the stipulated thyroid-stimulating hormone (TSH) levels range so as to minimize any potential long-term adverse effects. However, various factors may result in their Levothyroxine (T4) under and over-replacement.Our study aimed to evaluate the mean daily dose of L-T4 replacement for Asian patients with primary hypothyroidism. Read More

    Pharmacokinetics of coadministration of levothyroxine sodium and alendronate sodium new effervescent formulation.
    Osteoporos Int 2017 Feb 16. Epub 2017 Feb 16.
    Division of Endocrinology Diabetes and Bone Disease, Icahn School of Medicine at Mt. Sinai, Atran Building, 1428 Madison Avenue, 4th Floor, Box 1055, New York, NY, 10029, USA.
    No clinically important pharmacokinetic interference of alendronate occurred between a new effervescent formulation of alendronate and levothyroxine when coadministered. The combination does not materially affect levothyroxine absorption.

    Introduction: Concurrent treatment of osteoporosis with alendronate (Aln) and hypothyroidism with levothyroxine (LT4) may be problematic because both drugs are to be taken separately after fasting overnight. Read More

    The Relationship between Iron Deficiency and Thyroid Function in Chinese Women during Early Pregnancy.
    J Nutr Sci Vitaminol (Tokyo) 2016 ;62(6):397-401
    Department of Nuclear Medicine, Suzhou Hospital Affiliated to Nanjing Medical University.
    Previous studies have identified an association between iron deficiency and thyroid function. We aimed to determine if there is a relationship between iron deficiency and thyroid function during the first trimester of pregnancy. Two thousand five hundred eighty-one pregnant women who presented for the first prenatal care were enrolled and divided into three groups, the mild iron deficiency (MID) group, iron deficiency anemia (IDA) group and normal control (NC) group, according to serum ferritin and hemoglobin levels. Read More

    Moderate-to-Severe Iodine Deficiency in the "First 1000 Days" Causes More Thyroid Hypofunction in Infants than in Pregnant or Lactating Women.
    J Nutr 2017 Feb 15. Epub 2017 Feb 15.
    Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland;
    Background: Iodine deficiency early in the life cycle-the "first 1000 days"-can cause hypothyroidism and irreversibly impair neuromotor development. However, the relative vulnerability among women and infants during this critical period is unclear, making it difficult for country-based programs with limited resources to prioritize their iodine interventions.Objective: Our aim was to determine the prevalence of thyroid hypofunction in women and infants living in an area of moderate-to-severe iodine deficiency. Read More

    Thyroid gland in chronic obstructive pulmonary disease.
    Adv Respir Med 2017 ;85(1):28-34
    The risk of chronic obstructive pulmonary disease (COPD), as well as thyroid diseases increases with age. COPD is a common systemic disease associated with chronic inflammation. Many endocrinological disorders, including thyroid gland diseases are related to systemic inflammation. Read More

    Thyroid status of iodine deficient newborn infants living in central region of Turkey: a pilot study.
    World J Pediatr 2017 Feb 14. Epub 2017 Feb 14.
    Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Talas Street, Kayseri, Turkey.
    Background: Iodine deficiency (ID) during the fetal and neonatal periods can lead to neonatal hypothyroidism. This study was conducted to evaluate the effect of ID on the thyroid hormone level of newborns living in Turkey.

    Methods: Between 1998 and 2013, 71 newborns with a urinary iodine concentration <100 μg/L were recruited into the study. Read More

    Hypothyroidism reduces mammary tumor progression via Β-catenin-activated intrinsic apoptotic pathway in rats.
    Histochem Cell Biol 2017 Feb 13. Epub 2017 Feb 13.
    Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Av. Adrián Ruiz-Leal s/n, CC855, Mendoza, Argentina.
    Experimental hypothyroidism retards mammary carcinogenesis promoting apoptosis of tumor cells. β-catenin plays a critical role in cell adhesion and intracellular signaling pathways conditioning the prognosis of breast cancer. However, the mechanistic connections associated with the expression of β-catenin in thyroid status and breast cancer are not known. Read More

    [Hematopoietic stem cells transplant in patients with common variable immunodeficiency. Is a therapeutic option?]
    Rev Alerg Mex 2017 Jan-Mar;64(1):121-125
    Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica. Ciudad de México, México.
    Background: Patients with common variable immunodeficiency show higher incidence of sinopulmonary and gastrointestinal infections, as well as lymphoproliferative and autoimmune diseases. The treatment of choice is replacement therapy with human gamma-globulin. Hematopoietic stem cell transplantation is a non-conventional therapeutic modality. Read More

    Thyroid dysfunction and nonalcoholic fatty liver disease.
    Minerva Endocrinol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Endocrinology, "Hippokration" General Hospital of Thessaloniki, Thessaloniki, Greece.
    Thyroid hormones are crucial for hepatic lipid and glucose metabolism. Nonalcoholic fatty liver disease (NAFLD), a very common and potentially serious disease of modern society, shares common clinical features with hypothyroidism, such as obesity, insulin resistance and dyslipidemia. Furthermore, in certain studies, increased prevalence of hypothyroidism was observed in patients with NAFLD. Read More

    FDA Approval Summary: Pembrolizumab for the Treatment of Patients with Unresectable or Metastatic Melanoma.
    Clin Cancer Res 2017 Feb 8. Epub 2017 Feb 8.
    Office of Oncology Drug Products, U.S. Food and Drug Administration.
    On December 18, 2015, the U.S. Food and Drug Administration (FDA) granted regular approval to pembrolizumab (KEYTRUDA®; Merck Sharp & Dohme Corp. Read More

    Prevalence, incidence, and associated co-morbidities of treated hypothyroidism. An update from a European population.
    Eur J Endocrinol 2017 Feb 8. Epub 2017 Feb 8.
    R Gnavi, Epidemiology Unit, ASL TO3, Grugliasco, Italy.
    Objective: Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy, and examine the association between hypothyroidism and multiple chronic comorbidities.

    Design And Methods: Data were obtained from drug prescription and hospital discharge databases. Read More

    Hypothyroidism and nephrotic syndrome: why, when and how to treat.
    Curr Vasc Pharmacol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Clinical Medicine, Sapienza University of Rome, Rome,. Italy.
    Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions. Read More

    Congenital Hypothyroidism: Facts, Facets & Therapy.
    Curr Pharm Des 2017 Feb 6. Epub 2017 Feb 6.
    Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh,. India.
    Back ground: Thyroid hormone (T3) is essential for normal development of children enabling brain development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no thyroid hormones. Such a condition is termed congenital hypothyroidism (CH). Read More

    Thyroid Dysfunction and Heart Failure: Mechanisms and Associations.
    Curr Heart Fail Rep 2017 Feb 8. Epub 2017 Feb 8.
    Division of Basic Immunology and Biomedical Sciences, Universidad del Valle-Campus San Fernando, Calle 4 B No. 36-00 Edificio 116 - Oficina 3001 (Tercer piso), Cali, Valle, Colombia.
    Purpose Of Review: The purpose of this review is to provide an update on the current knowledge of the pathophysiology, the mechanisms, and the cardiovascular impact of the different stages of thyroid dysfunction (TD) in heart failure (HF) patients.

    Recent Finding: The influence of thyroid hormones (THs) on the cardiovascular system involves the regulation of key processes related to maintenance of cardiac function; however, there are no long-term studies available showing that intervening the TD changes the incidence or the prognosis in HF individuals. Future research shall focus on the effects of cardiovascular morbidity and mortality associated with different treatment modalities for hyper and hypothyroidism. Read More

    Effects of aerobic and anaerobic exercise on spatial learning ability in hypothyroid rats: a pilot study.
    J Phys Ther Sci 2016 Dec 27;28(12):3489-3492. Epub 2016 Dec 27.
    Department of Physical Therapy, Dong-Eui Institute of Technology, Republic of Korea.
    [Purpose] This pilot study analyzed the degradation of spatial learning ability caused by hypothyroidism using aerobic and anaerobic exercise. [Subjects and Methods] The experiments were performed on 11, four-week-old male Sprague-Dawley rats. Hypothyroidism-induced rats receiving propylthiouracil (PTU) treatment were divided into aerobic exercise, anaerobic exercise, and control groups. Read More

    Pharmacoepidemiology of Clinically Relevant Hypothyroidism and Hypertension from Sunitinib and Sorafenib.
    Oncologist 2017 Feb 6. Epub 2017 Feb 6.
    DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
    Background: Thyroid dysfunction and hypertension (HTN) have been sporadically reported with sunitinib (SUN) and sorafenib (SOR). Determination of the side effect incidence will enhance monitoring and management recommendations.

    Methods: An observational cohort study was performed using deidentified pharmacy claims data from a 3-year period to evaluate patients prescribed SUN, SOR, or capecitabine (CAP; comparison group). Read More

    Prevalence of Sensory Neuropathy in Type 2 Diabetes Mellitus and Its Correlation with Duration of Disease.
    Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):120-124
    Department of Cardiology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
    Background Peripheral neuropathy is one of the most common and distressing late complication of diabetes mellitus. Ignorance of the complications may develop foot ulcers and gangrene requiring amputation. Objective The main objective of this study is to find out the prevalence of sensory neuropathy in type 2 diabetes mellitus and to compare it with the duration of disease. Read More

    Exercise-induced Hypoxemia in Juvenile Thyroid Carcinoma With Lung Metastases.
    Pediatr Exerc Sci 2017 Feb 6:1-24. Epub 2017 Feb 6.
    1 University Children's Hospital, Würzburg, Germany.
    Purpose: Exercise-induced arterial hypoxemia (EIAH) has been reported in patients with juvenile thyroid cancer treated with radioiodine for lung metastases. This retrospective study tested the hypothesis that EIAH is due to ventilation-perfusion-mismatch in this rare pulmonary condition.

    Method: 50 patients (age 13 -23 years) treated for juvenile thyroid carcinoma and lung metastasis with 131I and 24 controls with thyroid cancer but without lung metastases and prior 131I-treatment were assessed in a state of acute hypothyroidism by computed tomography of the lungs, pulmonary function testing, cardiopulmonary exercise test with measurements of gas exchange, oxygen saturation, alveolar-arterial difference in pO2 (p(A-a)O2) and pCO2 (p(ET-a)CO2). Read More

    Surgical safety analysis of retaining the glands in papillary thyroid microcarcinoma.
    Eur Rev Med Pharmacol Sci 2017 Jan;21(2):234-238
    The Third General Surgery, The Central Hospital of Zhumadian City, Zhumadian City, China.
    Objective: The objective of the present study was to analyze the surgical safety of retaining the glands in papillary thyroid microcarcinoma (mPTC).

    Patients And Methods: 156 cases of mPTC were retrospectively reviewed and divided into four groups according to the treatment: group A (conservative follow-up group, 30 cases), group B (total resection of unilateral gland combined with isthmic resection, 48 cases), group C (total resection of unilateral gland combined with subtotal resection of contralateral gland, 47 cases), and group D (total resection of bilateral glands, 31 cases). The average follow-up time was 34. Read More

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