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    Central hypothyroidism - a neglected thyroid disorder.
    Nat Rev Endocrinol 2017 May 26. Epub 2017 May 26.
    Department of Biomedical Sciences, Humanitas University and Endocrinology Unit, Humanitas Research Hospital, Via Manzoni 56, Rozzano 20086, Italy.
    Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital. Read More

    [Diabetic ketoacidosis with mild hyperglycemia associated with the use of canagliflozin. Report of one case with type 1 diabetes].
    Rev Med Chil 2017 Mar;145(3):393-396
    Hospital San Martín, Quillota, Chile.
    Diabetic ketoacidosis with mild hyperglycemia is a major complication of sodium-glucose cotransporter 2 inhibitors. Although its use is not approved for patients with type 1 diabetes mellitus, the drug is often prescribed with the hope of optimizing metabolic control. We report a 20 years old female with hypothyroidism and type 1 diabetes consulting for vomiting and abdominal pain. Read More

    Modification of infant hypothyroidism and phenylketonuria screening program using electronic tools.
    J Educ Health Promot 2017 19;6. Epub 2017 Apr 19.
    Department of Information Technology, Health Information Technology, Health Vice-Chancellery, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Congenital hypothyroidism and phenylketonuria (PKU) are the most common cause for preventable mental retardation in infants worldwide. Timely diagnosis and treatment of these disorders can have lasting effects on the mental development of newborns. However, there are several problems at different stages of screening programs that along with imposing heavy costs can reduce the precision of the screening, increasing the chance of undiagnosed cases which in turn can have damaging consequences for the society. Read More

    Outcome of in vitro fertilization in women with subclinical hypothyroidism.
    Reprod Biol Endocrinol 2017 May 25;15(1):39. Epub 2017 May 25.
    Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan Province, 650500, People's Republic of China.
    Background: Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated SCH women whose serum Thyroid Stimulating Hormone (TSH) concentration did and did not exceed 2.5 mIU/L before the IVF cycle has not been studied thoroughly. Read More

    Psychiatric and physical comorbidities and their impact on the course of bipolar disorder: A prospective, naturalistic 4-year follow-up study.
    Bipolar Disord 2017 May 22. Epub 2017 May 22.
    Bipolar Center Wiener Neustadt, Wiener Neustadt, Vienna, Austria.
    Objectives: The aim of the present study was to increase the available evidence on how physical and psychiatric comorbidities influence the long-term outcome in bipolar I and II disorder.

    Methods: We examined the prevalence of comorbid physical (metabolic, cardiovascular, thyroid, and neurological) diseases and psychiatric (neurotic, stress-related, somatoform, and personality) disorders and their impact on the risk of relapse in bipolar disorder. A total of 284 consecutively admitted patients with ICD-10 bipolar I (n=161) and II (n=123) disorder were followed up naturalistically over a period of 4 years. Read More

    Subclinical hypothyroidism and risk of cerebral small vessel disease: a hospital-based observational study.
    Clin Endocrinol (Oxf) 2017 May 25. Epub 2017 May 25.
    Department of Neurology, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210002, P.R. China.
    Objective: Subclinical hypothyroidism (SCH) has been associated with atherosclerosis and increased risk of ischemic stroke. However, whether SCH is associated with cerebral small vessel disease (cSVD) remains largely unexplored. This study aimed to investigate the relationship between SCH and total cSVD burden, a composite measurement detected with magnetic resonance imaging (MRI), in patients with minor ischemic stroke or transient ischemic attack (TIA). Read More

    Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population.
    PLoS One 2017 23;12(5):e0178100. Epub 2017 May 23.
    International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function. Read More

    Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.
    Yonsei Med J 2017 Jul;58(4):888-890
    Department of Endocrinology and Metabolism, The Second Hospital Affiliated to Guilin Medical College, Guilin, P.R. China.
    The mutations in the dual oxidase 2 (DUOX2) and dual oxidase maturation factor 2 (DUOXA2) genes can cause congenital hypothyroidism (CH). This study reports the pedigree with goitrous congenital hypothyroidism (GCH) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 genes. The two sisters with GCH were diagnosed with CH at neonatal screening and were enrolled in this study. Read More

    Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism.
    Med Sci Monit 2017 May 25;23:2519-2526. Epub 2017 May 25.
    Department of Internal Medicine, Division of Endocrinology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey.
    BACKGROUND Hypothyroid has several effects on the cardiovascular system. Global myocardial performance index (MPI) is used in assessment of both left ventricular (LV) systolic and diastolic function. We compared MPI in hypothyroidism patients vs. Read More

    High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function.
    Int J Hyperthermia 2017 Apr 24:1-7. Epub 2017 Apr 24.
    c Department of Radiology , The University of Hong Kong , Hong Kong SAR , PR China.
    Background: High intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. However, its effect on underlying thyroid function remains unknown. We aimed to evaluate the 6 months changes in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) after HIFU treatment. Read More

    Single-session high intensity focussed ablation (HIFU) versus open cervical hemithyroidectomy for benign thyroid nodule: analysis on early efficacy, safety and voice quality.
    Int J Hyperthermia 2017 Mar 24:1-7. Epub 2017 Mar 24.
    c Division of Speech and Hearing Sciences , The University of Hong Kong , Hong Kong , Hong Kong, China.
    Background: High intensity focussed ultrasound (HIFU) is a promising non-surgical treatment for symptomatic benign thyroid nodule. We aimed to compare early efficacy, safety and voice quality between HIFU ablation and open thyroidectomy.

    Methods: Consecutive patients who underwent single-session HIFU ablation or a hemithyroidectomy for symptomatic benign thyroid nodule were included. Read More

    Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature.
    Case Rep Endocrinol 2017 2;2017:4285457. Epub 2017 May 2.
    Endocrinology, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.
    Myxedema crisis is a life-threatening extreme form of hypothyroidism with a high mortality rate if left untreated. Myxedema crisis is commonly seen in older patients, especially in women, and is associated with signs of hypothyroidism, hypothermia, hyponatraemia, hypercarbia, and hypoxemia. Patients might present with different organ specific symptoms. Read More

    Prescription patterns of long-acting somatostatin analogues.
    SAGE Open Med 2017 9;5:2050312117694795. Epub 2017 Mar 9.
    Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia.
    Background: Acromegaly and endocrine tumors are uncommon morbidities that are currently treated with different drugs.

    Objective: To determine the prescription patterns of somatostatin analogues in patients affiliated with the Health System of Colombia.

    Methods: Retrospective cohort study of patients of any age and sex treated with octreotide or lanreotide between January 2011 and August 2015. Read More

    [Value of ultrasound shear wave elasticity imaging in diagnosis of Hashimoto's thyroiditis].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 May;37(5):683-686
    Department of Ultrasound, First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China.E-mail:
    Objective: To investigate the correlation between Young's modulus of the thyroid tissue measured by in shear wave elastography (SWE) and the clinical manifestations of Hashimoto's thyroiditis in different stages.

    Methods: A total of 104 patients with the clinical diagnosis of Hashimoto's thyroiditis were enrolled in this study, including 26 with hyperthyroidism, 29 with normal thyroid function, 27 with subclinical hypothyroidism, 22 with clinical hypothyroidism, with 50 healthy volunteers serving as the healthy control group. All the subjects underwent SWE to obtain the Young's modulus value of the thyroid tissue. Read More

    Cost-effectiveness of using recombinant human thyroid-stimulating hormone before radioiodine ablation for thyroid cancer treatment in Spanish hospitals.
    Rev Esp Med Nucl Imagen Mol 2017 May 20. Epub 2017 May 20.
    UGC Medicina Nuclear, Servicio de Medicina Nuclear, Hospital Virgen de las Nieves, Granada, España.
    Objectives: In thyroid cancer treatment, the thyroid-stimulating hormone (TSH) must be elevated before radioiodine ablation, either by exogenous (with recombinant human thyrotropin [rhTSH]) or endogenous stimulation by thyroid hormone withdrawal (THW). The use of rhTSH avoids hypothyroidism and favours the subsequent elimination of radioiodine, but involves the cost of the product. For this reason, a cost-effectiveness analysis was performed, taking into account all costs involved and the benefits associated with the use of this therapy. Read More

    Myxedema coma: A case report of pediatric emergency care.
    Medicine (Baltimore) 2017 May;96(21):e6952
    aPediatric Critical Care Medicine, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine bDepartment of Pediatric Endocrinology/Genetics, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai, China.
    Raionale: Myxedema coma (MC) is extremely rare but lethal in pediatric patients with hypothyroidism leading to altered mental status and hypothermia. But there is no clinical guideline for such cases.

    Patient Concerns: A 6-year-old Chinese girl presented with coma and hypothermia preceded by pneumonia. Read More

    Late Effects in Pediatric High-risk Neuroblastoma Survivors After Intensive Induction Chemotherapy Followed by Myeloablative Consolidation Chemotherapy and Triple Autologous Stem Cell Transplants.
    J Pediatr Hematol Oncol 2017 May 23. Epub 2017 May 23.
    *Division of Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago †Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago ‡Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Multimodal treatment in high-risk neuroblastoma has modestly improved survival; limited data exist on the late effects from these regimens. We report the sequelae of treatment incorporating 3 consecutive cycles of high-dose therapy and autologous stem cell transplants (ASCTs) without the use of total body irradiation (TBI). We reviewed the medical records of 61 patients treated on or following the Chicago Pilot 2 protocol between 1991 and 2008. Read More

    Normocephalic Pancraniosynostosis: A Report of a Surgical Technique.
    J Craniofac Surg 2017 May 19. Epub 2017 May 19.
    *Department of Craniofacial Surgery †Baylor Scott and White, Temple, TX.
    Normocephalic pancraniosynostosis is defined as the premature fusion of 3 or, more major sutures in the absence of another primary etiology, including primary, microcephaly, ventriculoperitoneal shunting, hypothyroidism, rickets, mucopolysaccharidoses, or other lysosomal storage diseases. It is very rare, thus far only 6 patients have been reported in the literature. Patients tend to present much later than those with single sutural, synostoses, and up to half have evidence of elevated intracranial pressure. Read More

    Thyroid homeostasis in mother-child pairs in relation to maternal iodine status: the MISA study.
    Eur J Clin Nutr 2017 May 24. Epub 2017 May 24.
    Department of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
    Background/objectives: Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function.

    Subjects/methods: Women from the Northern Norway Mother-and-Child contaminant Cohort Study (MISA) donated a blood and urine sample at three visits during their pregnancy and postpartum period (in second trimester, 3 days and 6 weeks after delivery. Read More

    Clinical Features of Nivolumab-Induced Thyroiditis: A Case Series Study.
    Thyroid 2017 May 24. Epub 2017 May 24.
    Kyoto University Graduate School of Medicine, Department of Diabetes, Endocrinology and Nutrition, Kyoto, Japan ;
    Background: The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. It consists of the PD-1 receptor and its two ligands, programmed death-ligand 1 (PD-L1) and programmed death-ligand 2 (PD-L2). Nivolumab is an anti-PD-1 monoclonal antibody approved for malignant melanoma, advanced non-small cell lung cancer, and advanced renal cell carcinoma in Japan. Read More

    Review of Heterotopic Thyroid Autotransplantation.
    Clin Exp Otorhinolaryngol 2017 May 24. Epub 2017 May 24.
    Department of Surgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Total thyroidectomy is increasingly accepted for the management of bilateral benign thyroid disorders. Postoperatively, patients require lifelong levothyroxine replacement therapy to avoid postoperative hypothyroidism, which besides the burden of compliance, has been proven to be associated with several long-term side effects. Heterotopic thyroid autotransplantation was proposed several decades ago to avoid the need for life-long postoperative replacement therapy with maintaining the autoregulatory mechanism of thyroxin production inside the body according to its needs. Read More

    Levothyroxine monotherapy versus levothyroxine and selenium combination therapy in chronic lymphocytic thyroiditis.
    J Endocrinol Invest 2017 May 22. Epub 2017 May 22.
    Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Bengbu, 233004, Anhui, China.
    Purpose: New strategies are needed for prevention and treatment of chronic lymphocytic thyroiditis (CLT). This study aimed to assess whether combination of levothyroxine treatment and selenium (Se) supplementation results in improved therapeutic effects in CLT compared with levothyroxine monotherapy.

    Methods: An open-label, randomized controlled study was performed in 60 CLT patients assigned to two groups. Read More

    Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis.
    J Endocrinol Invest 2017 May 22. Epub 2017 May 22.
    Endocrinology Department, Cesar Milstein Hospital, 951 La Rioja St, 1221, Buenos Aires, Argentina.
    Purpose: Overt hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients. Read More

    Pediatric Hypothyroidism: Diagnosis and Treatment.
    Paediatr Drugs 2017 May 22. Epub 2017 May 22.
    Thyroid Program, Division of Endocrinology, Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
    Thyroid hormone has important physiologic functions in nearly every organ system. The critical role of thyroid hormone in growth and in physical and neurologic development lends particular importance to the prompt diagnosis and appropriate treatment of hypothyroidism in infants and children. Congenital hypothyroidism is common and has potentially devastating neurologic consequences. Read More

    Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study.
    Radiother Oncol 2017 May 19. Epub 2017 May 19.
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:
    Background And Purpose: This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT).

    Material And Methods: We identified 14,893 NPC patients and 16,105 other head and neck cancer (HNC) patients treated with RT without thyroidectomy from the National Health Insurance Research Database in Taiwan between 2000 and 2011. Each NPC patient was randomly frequency-matched with four individuals without NPC by age, sex, and index year. Read More

    A Retrospective Chart Review of Lithium Side Effects in a Geriatric Outpatient Population.
    Am J Geriatr Psychiatry 1994 Autumn;2(4):346-351. Epub 2013 Jan 28.
    From the University of Virginia, School of Medicine.
    The charts of 114 elderly outpatients with mood disorders treated with lithium were reviewed to determine the incidence of side effects. Patients had been treated with lithium for an average of 7.5 years, with an average serum lithium level of 0. Read More

    Harefuah 2016 Aug;155(8):495-497
    Pediatric Intensive Care Unit, The Barzilai Medical Center affiliated with the Ben Gurion University of the Negev, Beer Sheva.
    Introduction: Both hypothyroidism and zinc deficiency have been diagnosed over a long time. The endemic character of both disorders inspired an investigation into the relationship between these two phenomena. Zinc has a role in multiple metabolic processes; therefore, zinc depletion may lead to a serious and prolonged illness. Read More

    Antithyroid Drug Therapy for Graves' Disease and Implications for Recurrence.
    Int J Endocrinol 2017 25;2017:3813540. Epub 2017 Apr 25.
    Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
    Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. Read More

    Occurrence of hyperprolactinemia in children with subclinical hypothyroidism.
    J Clin Res Pediatr Endocrinol 2017 May 22. Epub 2017 May 22.
    Background: Prevalence of hyperprolactinemia in children with subclinical hypothyroidism (ScH) is not known. This study aimed to determine the occurrence and predictors of hyperprolactinemia in children with euthyroidism, ScH and overt primary hypothyroidism (OPH).

    Methods: Consecutive children <18 years age, diagnosed to have normal thyroid function, ScH or OPH underwent serum prolactin estimation. Read More

    Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha.
    Curr Top Dev Biol 2017 21;125:337-355. Epub 2017 Mar 21.
    Erasmus University Medical Center, Rotterdam, The Netherlands.
    Background: Thyroid hormone (TH) acts via nuclear thyroid hormone receptors (TRs). TR isoforms (TRα1, TRα2, TRβ1, TRβ2) are encoded by distinct genes (THRA and THRB) and show differing tissue distributions. Patients with mutations in THRB, exhibiting resistance within the hypothalamic-pituitary-thyroid axis with elevated TH and nonsuppressed thyroid-stimulating hormone (TSH) levels, were first described decades ago. Read More

    [Profile of lithium carbonate use in patients with bipolar disorder in Colombia].
    Biomedica 2017 Apr 1;37(0):43-50. Epub 2017 Apr 1.
    Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma, S. A., Pereira, Colombia.
    Introduction: Lithium is the drug of choice for the treatment of bipolar affective disorder.

    Objective: To define lithium therapeutic profile and adverse reactions to its use in patients with bipolar affective disorder in Colombia.

    Materials And Methods: We conducted an observational retrospective cohort study between January 1 and December 31, 2013, which included patients with a diagnosis of bipolar disorder treated with lithium carbonate in 25 Colombian cities; we evaluated socio-demographic variables, lithium dose, co-medication, drug interactions and adverse reactions. Read More

    Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study from Turkey.
    J Pediatr Endocrinol Metab 2017 May 18. Epub 2017 May 18.
    Background: Endocrine organs are highly susceptible to effects of high-dose chemotherapy. The objective of the study was to evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children.

    Methods: The patients who underwent HSCT in our center from April 2010 to October 2014 with at least 1 year follow-up were analyzed retrospectively. Read More

    Neonatal Endocrinologic Problems in Collodion Babies.
    Pediatr Dermatol 2017 May;34(3):290-294
    Division of Neonatology , Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Objectives: To identify endocrinologic problems, particularly those concerning growth, in collodion babies (CBs).

    Methods: Clinically identified newborn CBs were included in the study group (group 1). Because CBs are generally born premature, small for gestational age (SGA), or both, a control group matched to the study group in terms of gestational age and birthweight (group 2) was also established. Read More

    The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers.
    Arch Immunol Ther Exp (Warsz) 2017 May 18. Epub 2017 May 18.
    Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
    Gli-similar 3 (Glis3) belongs to a Glis subfamily of Krüppel-like zinc-finger transcription factors characterized to regulate a set of downstream targets essential for cellular functions, including pancreatic development, β-cell maturation and maintenance, and insulin production. Examination of the DNA-binding domain of Glis3 reveals that this domain contains a repeated cysteine 2/histidine 2 (Cys2/His2) zinc-finger motif in the central region where the recognized DNA sequence binds. The loss of the production of pancreatic hormones, such as insulin 1 and 2, is linked to the down-regulation of β cells-related genes and promotes the apoptotic death of β cells found in mutant Glis3. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a systematic review.
    J Ther Ultrasound 2017 17;5:11. Epub 2017 May 17.
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR China.
    Background: With an increasing number of imaging studies being done nowadays, the number of incidentally discovered thyroid nodules is expected to rise. Although many of these nodules are small and benign in nature, some do grow and may cause pressure and/or thyrotoxic symptoms. Surgical resection has traditionally been recommended for symptomatic nodules but is associated with risk of hypothyroidism, bleeding, infection, and nerve damage. Read More

    Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis.
    J Endocrinol Invest 2017 May 17. Epub 2017 May 17.
    Department of Endocrinology, Gansu Provincial Hospital, Dong gang West Road, Lanzhou, 730000, Gansu, People's Republic of China.
    Purpose: To investigate the relationship between hypothyroidism, hyperthyroidism, thyroid hormone replacement, and the risk of breast cancer.

    Methods: We searched the PubMed, Cochrane Library, EMbase, Web of Science, and China Biology Medicine (CBM) databases through June 2016 to identify researches that assessed the relationship between thyroid dysfunction and the risk of breast cancer together with the impact of thyroid hormone substitution treatment on incidence of breast cancer. Quality of evidence was assessed per outcome, using GRADE. Read More

    Sub-Clinical Hypothyroidism and Its Association With Increased Cardiovascular Mortality: Call for Action.
    Cardiol Res 2017 Apr 3;8(2):31-35. Epub 2017 May 3.
    Anderson M.D. Hospital, USA.
    Thyroid hormones play an important role in regulating different functions regarding metabolism and performance in multiple organs. Any change in the thyroid hormones axis can lead to profound effect on the vital organ stability especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. Read More

    Congenital central hypothyroidism caused by a novel TSH-beta-subunit gene mutation (c.94G>A ) in two siblings.
    J Clin Res Pediatr Endocrinol 2017 May 17. Epub 2017 May 17.
    Congenital central hypothyroidism (C-CH) is a very rare disease. Alterations in genes included in pituitary development, mutations of the immunoglobulin superfamily member 1 (IGSF1) and transducin β-like protein 1(TBL1X ) can result in C-CH with multiple pituitary hormone deficiencies. However, mutations of the thyrotropin-releasing hormone receptor or TSH-beta (TSHB) gene are responsible for isolated congenital central hypothyroidism. Read More

    Learning curve for the endoscopic endonasal approach for suprasellar craniopharyngiomas.
    J Clin Neurosci 2017 May 13. Epub 2017 May 13.
    Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, PR China.
    The endoscopic endonasal approach is considered an alternative minimally invasive approach for suprasellar craniopharyngiomas. However, the complicated surgical manipulations required by this approach have limited its application. We evaluate whether the approach features a learning curve. Read More

    Light Chain Myeloma induced Severe Hypertriglyceridemia.
    J Clin Diagn Res 2017 Mar 1;11(3):OD01-OD03. Epub 2017 Mar 1.
    Professor, Department of Medicine, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Hyperlipidemia is very common in general population and incidence has further increased in recent years. Evaluation of patient presenting with lipid disorders is essential to obtain a definite diagnosis to prevent complications, and apply the most appropriate treatment. An isolated elevation in triglyceride levels may be caused by a primary disorder of lipid metabolism like familial hypertriglyceridemia. Read More

    An Analysis of Dynamic Pulmonary Functions of Hypothyroid Patients.
    J Clin Diagn Res 2017 Mar 1;11(3):CC10-CC12. Epub 2017 Mar 1.
    Professor and Head, Department of Physiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
    Introduction: Hypothyroidism is a silent epidemic of our times. In India, the prevalence of hypothyroidism is 11%. The effect of hypothyroidism on respiratory system is debatable with studies suggesting both obstructive and restrictive disease patterns. Read More

    A case of minimal change nephrotic syndrome with hypothyroidism deterioration.
    CEN Case Rep 2016 May 26;5(1):95-98. Epub 2015 Oct 26.
    Department of Pathology, Tachikawa Sogo Hospital, 1-16-15 Nishiki-cho, Tachikawa, Tokyo, Japan.
    A 73-year-old woman with Graves' disease underwent total thyroidectomy and was being treated with levothyroxine. She developed edema in the lower region of both legs 1 month before hospitalization. She had a high concentration of urine protein and was hospitalized for further assessment. Read More

    Ultrasound Elastography in Pediatric Congenital Hypothyroid Patients.
    Pediatr Endocrinol Rev 2016 Sep;14(1):48-53
    Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Radiology, Kahramanmaras, Turkey.
    Objectives: Congenital hypothyroidism (CH) is most frequently encountered in newborns as an endocrine disorder characterized by thyroid hormone deficiency, and is one of the most common reasons for preventable mental retardation. This prospective study was designed to detect the pediatric occurrences of CH followed as euthyroid, with no anomalies detected via US on the gray scale, in comparison with a pediatric group with normal levels.

    Methods: A total of 42 apparently healthy children with no thyroid disorder (Group 1) and 54 euthyroid CH (Group 2) using thyroid hormone were included in this study. Read More

    No Association between 25 (OH) Vitamin D Level And Hypothyroidism among Females.
    Open Access Maced J Med Sci 2017 Apr 19;5(2):126-130. Epub 2017 Mar 19.
    Faculty of Medicine, Khartoum University, Khartoum, Sudan.
    Aim: The aim was to investigate serum vitamin D (25-OH) level among females with hypothyroidism.

    Materials And Methods: A case-control study (58 in each arm) was conducted in Arar Central Hospital, Kingdom Saudi Arabia. The cases were females with hypothyroidism, and healthy females were controls. Read More

    Rationality in prophylactic central neck dissection in clinically node-negative (cN0) papillary thyroid carcinoma: Is there anything more to say? A decade experience in a single-center.
    Int J Surg 2017 May;41 Suppl 1:S40-S47
    Division of General Surgery, Department of Medical, Surgical and Health Sciences, Cattinara Teaching Hospital, Strada di Fiume, 34149, Trieste, Italy.
    Aim: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Despite its extremely favorable prognosis, cervical lymph node metastases are a common feature of PTC and a known independent risk factor for local recurrence. However, the role of prophylactic central neck dissection (PCND) remains a matter of debate in patients with clinically node-negative (cN0) PTC. Read More

    [Cornelia de Lange Syndrome and multiple hormonal deficiency, an unusual association. Clinical case].
    Arch Argent Pediatr 2017 Jun;115(3):e170-e174
    Escuela de Medicina, Universidad Industrial de Santander.
    Cornelia de Lange syndrome is a genetic disease characterized by distinctive facial features, failure to thrive, microcephaly and several malformations associated. Its main endocrinological features are anomalies of the genitalia. We present a 13-year-old boy, who suffered from complicated aspiration pneumonia and showed Cornelia de Lange syndrome phenotype, with global developmental delay, suction-swallowing abnormalities, short stature and abnormal genitalia associated. Read More

    [Transient congenital hypothyroidism due to biallelic defects of DUOX2 gene. Two clinical cases].
    Arch Argent Pediatr 2017 Jun;115(3):e162-e165
    Centro de Investigaciones Endocrinológicas (CEDIE)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Fundación de Endocrinología Infantil (FEI)-División de Endocrinología, Hospital de Niños R. Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
    Congenital hypothyroidism affects 1:2000-3000 newborns detected by neonatal screening programs. Dual oxidases, DUOX1 and 2, generate hydrogen peroxide needed for the thyroid hormone synthesis. Hipotiroidismo congénito transitorio por defectos bialélicos del gen DUOX2. Read More

    A Video Report of Brain-Lung-Thyroid Syndrome in a Japanese Female With a Novel Frameshift Mutation of the NKX2-1 Gene.
    Child Neurol Open 2016 Jan-Dec;3:2329048X16665012. Epub 2016 Aug 24.
    Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Benign hereditary chorea is a rare autosomal-dominant disorder that is characterized by childhood-onset nonprogressive chorea and normal cognitive function. Defects in NKX2-1 on chromosome 14q13, which encodes thyroid transcription factor 1, produce a concurrent clinical manifestation of chorea, respiratory distress, and hypothyroidism known as "brain-lung-thyroid syndrome." Here, the authors describe a video report of benign hereditary chorea in a Japanese female with a novel frameshift mutation of NKX2-1 (c. Read More

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