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    Evaluation of UMELISA(®) T4 Neonatal and UMELISA(®) T4 using polystyrene plates coated with anti-thyroxine (T4) monoclonal antibodies.
    J Immunoassay Immunochem 2017 Nov 16. Epub 2017 Nov 16.
    Congenital hypothyroidism is one of the most common preventable causes of mental retardation. The Center of Immunoassay has developed the UMELISA(®) T4 NEONATAL and UMELISA(®) T4 to determine neonatal T4 levels in dried blood and serum samples. Both reagent kits use the same polystyrene plates coated with anti- thyroxine (T4) polyclonal antibodies as solid phase. Read More

    Two threshold levels of vitamin D and the prevalence of comorbidities in outpatients of a tertiary hospital.
    Osteoporos Int 2017 Nov 15. Epub 2017 Nov 15.
    Serviço de Endocrinologia e Metabologia do Hospital de Clínicas, da Universidade Federal do Paraná (SEMPR), Curitiba, PR, Brazil.
    This study evaluated the number of comorbidities between two normal values of 25OHD in outpatients during 1 year of 25OHD measurements. Five hundred twenty-nine outpatients were included, patients with 25OHD ≥ 20 and < 30 ng/mL had the higher number of comorbidities, suggesting that for this specific population, 25OHD ≥ 30 ng/mL would be more appropriate. INTRODUCTION : This study evaluated the comorbidities between two values of 25OHD in outpatients of a tertiary hospital. Read More

    A Rare Double Aneuploidy Case (Down-Klinefelter).
    J Pediatr Genet 2017 Dec 6;6(4):241-243. Epub 2017 Jul 6.
    Department of Medical Genetics, Balcali Clinics and Hospital, Faculty of Medicine, Cukurova University, Adana, Turkey.
    Down's syndrome has its own dysmorphic findings and is accompanied by mental retardation and hypotonia. Klinefelter's syndrome is a syndrome caused by a numerical abnormality that affects male physical and cognitive development. This case reports a unique finding of 48,XXY, + 21 and a current literature review. Read More

    Congenital Hypothyroidism in Neonates of a Tertiary Care Hospital.
    Pak J Med Sci 2017 Sep-Oct;33(5):1269-1272
    Khalil ur Rehman, FCPS. Professor of Pathology, Sahiwal Medical College, Sahiwal, Pakistan.
    Objective: To determine neonatal congenital hypothyroidism among neonates born in a tertiary care hospital of Lahore Pakistan.

    Methods: This cross-sectional study was carried out at Pathology Department of Allama Iqbal Medical College, Lahore in collaboration with Pediatrics and Gynecology & Obstetrics Department, Jinnah Hospital, Lahore Pakistan. A total of 770 babies were included in this study, both male and female. Read More

    An evaluation of thyroid autoimmunity in patients with beta thalassemia minor: A case-control study.
    Pak J Med Sci 2017 Sep-Oct;33(5):1106-1111
    Mehmet Ali Cikrikcioglu, Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, 34093, Istanbul, Turkey.
    Objective: The tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). The aim of this study was to evaluate whether thyroid autoimmunity is higher in BTM.

    Methods: Patients with BTM (n=86) and a healthy control group (n=93) were included in this cross-sectional case-control study. Read More

    Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring.
    Sci Rep 2017 Nov 15;7(1):15591. Epub 2017 Nov 15.
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
    This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Read More

    A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia.
    Intern Med 2017 15;56(22):3047-3050. Epub 2017 Nov 15.
    Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, Japan.
    We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination revealed that the patient's carbamazepine concentration was at the upper limit of the standard range, as well as hypothyroidism. Read More

    Neuromyelitis optica spectrum disorders in Iran.
    Mult Scler Relat Disord 2017 Nov 9;18:209-212. Epub 2017 Oct 9.
    MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Background: Neuromyelitys optica spectrum disorder (NMOSD) is a rare demyelinating disease; as a result, the epidemiological data on this disorder is scarce. In this regard, the aim of this study was to estimate the prevalence, serology, and clinical features of NMOSD in Caucasian population in Tehran, Iran.

    Method: A cross sectional study was performed in Tehran from 2015 to 2016 among patients registered with NMOSD diagnosis, based on consensus criteria published in 2015. Read More

    Oxidative stress biomarkers in amniotic fluid of pregnant women with hypothyroidism.
    J Matern Fetal Neonatal Med 2017 Nov 15:1-6. Epub 2017 Nov 15.
    b Department of Biomedical Sciences , State University of Novi Pazar , Novi Pazar , Serbia.
    Purpose: Hypothyroidism in pregnancy is the serious state that may lead to fetal morbidity and mortality. Oxidative stress biomarkers in the amniotic fluid can provide important information on the health, development and maturation of the fetus during pregnancy. In this study, we examined whether maternal hypothyroidism contributes to increased oxidative stress biomarkers in the amniotic fluid during the first trimester of pregnancy. Read More

    Primary Malignant Melanoma of the Bladder.
    Skinmed 2017 1;15(5):395-397. Epub 2017 Oct 1.
    Department of Dermatology, Campus Bio-Medico University, Rome, Italy;
    A 81-year-old man was admitted to our university for a second opinion after diagnosis of bladder melanoma in December 2014. His medical history included arterial hypertension, hypothyroidism, peripheral arterial disease treated with a bypass, and corneal transplantation. His medical history was negative for malignant melanoma. Read More

    Endocrine manifestations of Down syndrome.
    Curr Opin Endocrinol Diabetes Obes 2017 Nov 11. Epub 2017 Nov 11.
    aDivision of Pediatric Endocrinology bDivision of General Academic Pediatrics, Department of Pediatrics cDepartment of Pediatrics, Down Syndrome Clinic, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
    Purpose Of Review: To summarize the recent developments in endocrine disorders associated with Down syndrome.

    Recent Findings: Current research regarding bone health and Down syndrome continues to show an increased prevalence of low bone mass and highlights the importance of considering short stature when interpreting dual energy x-ray absorptiometry. The underlying cause of low bone density is an area of active research and will shape treatment and preventive measures. Read More

    Risk of falling among hospitalized patients with high modified Morse scores could be further Stratified.
    BMC Health Serv Res 2017 Nov 13;17(1):721. Epub 2017 Nov 13.
    Internal Medicine T Department, Chaim Sheba Medical Center, 5265601, Tel-Hashomer, Israel.
    Background: Falls during hospitalization harbor both clinical and financial outcomes. The modified Morse fall scale [MMFS] is widely used for an in-hospital risk-of-fall assessment. Nevertheless, the majority of patients at risk of falling, i. Read More

    Thyroid Dysfunction States and Incident Cardiovascular Events: The Tehran Thyroid Study.
    Horm Metab Res 2017 Nov 13. Epub 2017 Nov 13.
    Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    The objective of the study was to investigate the relation of different thyroid function states with the incidence of cardiovascular disease (CVD)/coronary heart disease (CHD) among a Middle-Eastern population with a high incidence of CVD/CHD. A total of 3975 participants entered the study (43.6% men). Read More

    Iodide Binding in Sodium-Coupled Cotransporters.
    J Chem Inf Model 2017 Nov 13. Epub 2017 Nov 13.
    Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial. Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide entry into the thyroid. Free-energy calculations using a force field with electronic polarizability verify the presence of a conserved iodide-binding pocket between the TM2, TM3, and TM7 segments in hNIS, where iodide is coordinated by Phe67, Gln72, Cys91, and Gln94. Read More

    Chylomicronemia risk factors ranked by importance for the individual and community in 108,711 women and men.
    J Intern Med 2017 Nov 11. Epub 2017 Nov 11.
    Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    Background: Hypertriglyceridemia prevalence is increasing as more individuals become obese, and chylomicronemia risk factors for the individual and community have not been described previously.

    Objective: To describe chylomicronemia risk factors in the general population for individuals and community.

    Methods: 108,711 individuals from the Copenhagen General Population Study were grouped as unlikely chylomicronemia (nonfasting triglycerides <2mmol/L(177 mg/dL)), possible chylomicronemia (2-4. Read More

    Thyroid evaluation of children and adolescents with Williams syndrome in Zhejiang Province.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    .
    Background: The objective of the study was to describe the prevalence of abnormal thyroid function and volume in children and adolescents with Williams syndrome (WS) in Zhejiang Province, China.

    Methods: Thyroid function, including thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroid antibodies (thyroid peroxidase and thyroglobulin) were measured in 83 patients with WS, aged 0.2-16. Read More

    Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike.
    Dig Dis Sci 2017 Nov 10. Epub 2017 Nov 10.
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
    Background: There is a gap in research focused on gender-based differences in non-referral populations with celiac disease.

    Aims: The aim of this study was to estimate those differences in a unique population-based cohort of patients with celiac disease with respect to (1) presenting symptoms, (2) associated autoimmune disorders, and (3) survival.

    Methods: Clinical data were systematically abstracted from the electronic medical record of a population-based incident cohort of patients with celiac disease. Read More

    Effects of Levothyroxine on pregnant women with subclinical hypothyroidism, negative for thyroid peroxidase antibodies.
    J Clin Endocrinol Metab 2017 Nov 6. Epub 2017 Nov 6.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Context: Currently, there is no consensus on universal thyroid screening and Levothyroxine (LT4) treatment of subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody (SCH-TPOAb-).

    Objective: We aimed to evaluate the benefits of LT4 treatment on pregnancy outcomes in SCH-TPOAb- women.

    Design: This study was conducted within the framework of the Tehran Thyroid and pregnancy study. Read More

    Hypothyroidism-induced Reversible Encephalopathy as a Cause of Aggravation of Parkinsonism and Myoclonus in Parkinson's Disease.
    Tremor Other Hyperkinet Mov (N Y) 2017 19;7:505. Epub 2017 Oct 19.
    Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea.
    Background: Myoclonus and encephalopathy are unusual in patients with Parkinson's disease (PD).

    Case Report: We describe the case of a 59-year-old male with PD who developed myoclonus and encephalopathy. Underlying hypothyroidism was revealed after admission and treated with levothyroxine. Read More

    Mid to long term outcomes of Laparoscopic Sleeve Gastrectomy in Indian population: 3-7 year results - A retrospective cohort study.
    Int J Surg 2017 Nov 6;48:201-209. Epub 2017 Nov 6.
    Department of Dietetics, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India. Electronic address:
    Introduction: Few studies have addressed the mid to long term impact of Laparoscopic Sleeve Gastrectomy (LSG) on weight loss and obesity associated co-morbidities, particularly in Indian population. The aim of this study is to assess the efficacy of LSG in morbid obesity over 3-7 years follow up.

    Materials And Methods: Data of all patients who underwent LSG between January 2008 and March 2015 and completed their at least 1 year follow up till March 2016 was retrospectively reviewed using a prospectively collected database. Read More

    Radiotherapy for Tracheal-Bronchial Cystic Adenoid Carcinomas.
    Clin Oncol (R Coll Radiol) 2017 Nov 6. Epub 2017 Nov 6.
    Department of Radiation Oncology, Gustave Roussy Cancer Campus, Institut d'Oncologie Thoracique (IOT), Université Paris-Saclay, Villejuif, France. Electronic address:
    Aims: Primary tracheal-bronchial adenoid cystic carcinoma (thoracic adenoid cystic carcinoma; TACC) is a rare and aggressive malignant tumour. Radiotherapy results have not been previously individualised in this setting.

    Patients And Methods: Records of 31 patients with TACC (74% tracheal and 26% bronchial) who received radiotherapy between February 1984 and September 2014 were retrospectively analysed. Read More

    [Hypothyroidism in patients with heart disease].
    Vnitr Lek 2017 ;63(9):566-571
    Hypothyroidism is frequently found in patients with heart disease. It is a risk factor for atherosclerosis and ischemic heart disease and has a direct negative effect on both the left and right ventricular functions (hypothyroidism-induced cardiomyopathy). The confirmed manifest hypothyroidism is always a reason for replacement therapy with levothyroxine; regarding patients with heart disease, we always begin treatment with a small dose and increase it gradually. Read More

    [Thyroid screening in pregnancy - guideline in practice].
    Vnitr Lek 2017 ;63(9):555-560
    Thyroid diseases may adversely affect the conception, maintain pregnancy. They increase the risk of complications in pregnancy and may have a negative effect on the fetus. Therefore it is necessary to capture thyroid diseases in the population of pregnant women, in the early stage of pregnancy. Read More

    [Thyroid disease in the Czech Republic: the EUthyroid project and the evaluation of the General Health Insurance Company epidemiological data for the period of 2012-2015].
    Vnitr Lek 2017 ;63(9):548-554
    Institute of Endocrinology participates in the grant of European Commission EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe), together with other 28 European countries. The role of Institute of Endocrinology in EUthyroid is among other things to ensure access to national registers relating to thyroid diseases. The results presented here correspond to the years 2012-2015 and are based on data from the General Health Insurance Company Czech Republic (VZP CR), which has 6 million insured persons (ratio male : female = 1 : 1). Read More

    Recurrent Admissions for Hypothermia From Concomitant Topiramate and Phenobarbital: A Case Report.
    J Pharm Pract 2017 Jan 1:897190017740465. Epub 2017 Jan 1.
    1 Pharmacy Department, WellSpan York Hospital, York, PA, USA.
    Introduction: This article presents an additional case of concomitant topiramate and phenobarbital administration that resulted in 8 hospital admissions for hypothermia that resolved after discontinuation of phenobarbital.

    Case: A 56-year-old white female with cerebral palsy and quadriplegia, epilepsy, and hypothyroidism was admitted to a community teaching hospital multiple times with documented hypothermia. These admissions followed a subsequent dose increase of topiramate in December 2014. Read More

    Elective nodal dose of 60 Gy or 50 Gy in head and neck cancers: A matched pair analysis of outcomes and toxicity.
    Adv Radiat Oncol 2017 Jul-Sep;2(3):339-345. Epub 2017 Jun 21.
    Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India.
    Purpose: The main objective of this study was to evaluate appropriate doses for elective nodal irradiation (ENI) in head and neck squamous cell carcinoma (HNSCC) patients to optimize the therapeutic ratio.

    Methods And Materials: A matched pair analysis of 2 similar cohorts of HNSCC treated with intensity modulated radiation therapy with different dose prescriptions to the elective nodal regions was conducted. One group received 60 Gy, whereas the other received 50 Gy (ENI60 and ENI50 groups, respectively). Read More

    Depression led pitting edema: A rarest case presentation.
    Int J Health Sci (Qassim) 2017 Nov-Dec;11(5):77-78
    Associate Professor, Department of Physiology, Chitwan Medical College Affiliated to Tribhuvan University, Chitwan, Nepal.
    Pitting edema is the clinical manifestation generally presented due to long standing, especially during summer in the sun, heavy weight bearing, vasodilatation, or cardio-hepatorenal disease or in rare hypothyroidism, but in atypical case may demonstrates depression with progressive stress, that also shows indication of mild pitting edema. We present a case of a non-alcoholic 42 years divorced male under anti-anxiety medication for 10 years who complained of weight gain almost 10 kg in 30 days duration, less attentive to his work, and always feel sleepiness during day (once get to sleep, slept more than 5 h during day) and also late up to morning if not called to wake-up, also with diminished memory, more specific event was before 60 days of these symptoms he unexpectedly suffered family tragedy suggesting depression led progressive stress pitting edema that got managed after appropriate counseling along with changes in his life style. Read More

    Individualizing surgery in papillary thyroid carcinoma based on a detailed sonographic assessment of extrathyroidal extension.
    Thyroid 2017 Nov 7. Epub 2017 Nov 7.
    UCLA David Geffen School of Medicine, Section of Endocrine Surgery , 10833 Le Conte Ave, 72-228 CHS , Los Angeles, California, United States , 90095.
    Background: Lobectomy may be sufficient for patients with intrathyroidal papillary thyroid carcinomas (PTC) < 4 cm without nodal metastasis. Based on the 2015 American Thyroid Association guidelines, a strategy using ultrasound to identify appropriate candidates for lobectomy was implemented.

    Methods: We retrospectively reviewed patients with Bethesda V or VI cytology who underwent surgery for PTC (January 2016 to May 2017). Read More

    Study on the status of thyroid function and thyroid nodules in chinese breast cancer patients.
    Oncotarget 2017 Oct 24;8(46):80820-80825. Epub 2017 Aug 24.
    Department of Endocrine and Breast Surgery of The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    We performed a study to investigate the status of thyroid nodules and thyroid functions in Chinese breast cancer women. The clinical data of female patients with breast cancer or benign breast diseases and normal populace were evaluated. The thyroxine(T4) level in initially diagnosed breast cancer patients were significantly higher than those in benign breast diseases patients (7. Read More

    Women's Health Endocrine Update.
    J Womens Health (Larchmt) 2017 Nov 7. Epub 2017 Nov 7.
    4 Division of Endocrinology, University of California at San Diego , San Diego, California.
    The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. Read More

    Repercussions of hypo and hyperthyroidism on the heart circadian clock.
    Chronobiol Int 2017 Nov 7:1-13. Epub 2017 Nov 7.
    b Department of Physiology and Biophysics , Institute of Biomedical Sciences-I, University of São Paulo , São Paulo , Brazil.
    Myocardial gene expression and metabolism fluctuate over the course of the day in association with changes in energy supply and demand. Time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of heart metabolism and function. Read More

    Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin.
    Case Rep Neurol Med 2017 4;2017:1351549. Epub 2017 Oct 4.
    Department of Neuroradiology, Cliniques Universitaires St-Luc, Brussels, Belgium.
    Among other autonomic dysfunctions complicating acute spinal cord injury, deep hypothermia is rare but may induce serious cardiovascular complications. There are few pharmacological options to influence hypothermia. A 66-year-old woman was transferred to the intensive care unit (ICU) for serious cardiac arrhythmias (atrial fibrillation and asystole) in the context of a deep hypothermia (axillary temperature below 32°C). Read More

    Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.
    Neurobiol Aging 2017 Nov 3;62:64-71. Epub 2017 Nov 3.
    Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Electronic address:
    Thyroid hormone disease is common among older adults and is associated with cognitive impairment. However, pathologic correlates are not well understood. We studied pathologic and clinical factors associated with hypothyroidism, the most common manifestation of thyroid disease, in research subjects seen annually for clinical evaluations at U. Read More

    Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism.
    Mol Metab 2017 Nov 19;6(11):1551-1561. Epub 2017 Aug 19.
    CNRS, UMR 7221, Sorbonne Universités, Muséum National d'Histoire Naturelle, F-75005 Paris France. Electronic address:
    Objective: In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and glial cells. Thyroid hormones (THs) regulate adult NSC differentiation towards a neuronal phenotype, but also have major roles in mitochondrial metabolism. As NSC metabolism relies mainly on glycolysis, whereas mature cells preferentially use oxidative phosphorylation, we studied how THs and mitochondrial metabolism interact on NSC fate determination. Read More

    Progression from isolated growth hormone deficiency to combined pituitary hormone deficiency.
    Growth Horm IGF Res 2017 Oct 19;37:19-25. Epub 2017 Oct 19.
    Developmental Endocrinology Research Group, UCL Institute of Child Health and Department of Endocrinology, Great Ormond Street Hospital for Children, WC1N 1EH, London, UK. Electronic address:
    Growth hormone deficiency (GHD) can present at any time of life from the neonatal period to adulthood, as a result of congenital or acquired insults. It can present as an isolated problem (IGHD) or in combination with other pituitary hormone deficiencies (CPHD). Pituitary deficits can evolve at any time from GHD diagnosis. Read More

    Subarachnoid Hemorrhage and Readmissions: National Rates, Causes, Risk Factors, and Outcomes in 16,001 Hospitalized Patients.
    World Neurosurg 2017 Oct 26. Epub 2017 Oct 26.
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
    Introduction: The acute complications of aneurysmal subarachnoid hemorrhage (aSAH) often lead to readmissions, which are linked to hospital reimbursement. The national rates, causes, risk factors, and outcomes associated with 30-day and 90-day readmission following aSAH have not previously been reported.

    Methods: The Nationwide Readmissions Database was queried from January through September 2013 for all patients (age ≥ 18) with a diagnosis of aSAH. Read More

    Clinical variables determining the success of adenotonsillectomy in children with Down syndrome.
    Int J Pediatr Otorhinolaryngol 2017 Nov 20;102:148-153. Epub 2017 Sep 20.
    Department of Otorhinolaryngology, Universidade Federal de São Paulo, Rua Pedro de Toledo 947, 04039-002, São Paulo, SP, Brazil. Electronic address:
    Objectives: To evaluate the evolution of polysomnographic parameters of children with Down syndrome and obstructive sleep apnea syndrome submitted to adenotonsillectomy and the interaction of comorbidities on therapeutic outcome.

    Methods: Ninety patients with Down syndrome and habitual snoring were identified between 2005 and 2015 in a Pediatric Otorhinolaryngology Clinic. Parent's complaints were evaluated by the test of equality of two proportions. Read More

    Symptomatic atrial fibrillation and risk of cardiovascular events: data from the Euro Heart Survey.
    Europace 2017 Jun 30. Epub 2017 Jun 30.
    Department of Biomedical Sciences and Public Health, Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital "Ospedali Riuniti", Via Conca 71, Ancona, Italy.
    Aims: Atrial fibrillation (AF) is associated with a wide range of clinical presentations. Whether and how AF symptoms can affect prognosis is still unclear. Aims of the present analysis were to investigate potential predictors of symptomatic AF and to determine if symptoms are associated with higher incidence of cardiovascular (CV) events at 1-year follow-up. Read More

    Effects of thyroid hormone replacement therapy on thyroid hormone levels and electrocardiogram changes in geriatric patients with hypothyroidism.
    Pak J Pharm Sci 2017 Sep;30(5(Supplementary)):1939-1942
    Department of Function, Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, China.
    This paper aims to analyze the effects of thyroid hormone replacement therapy on thyroid hormone levels and electrocardiogram changes in elderly patients with hypothyroidism. 48 elderly patients with hypothyroidism admitted to our hospital from January 2014 to December 2014 were selected as subjects. All the patients were treated with thyroid hormone replacement therapy. Read More

    Analysis of current thyroid function test ordering practices.
    J Eval Clin Pract 2017 Nov 3. Epub 2017 Nov 3.
    Endocrinology Service, San Antonio Military Medical Center, San Antonio, USA.
    Rationale: Current guidelines recommend thyroid stimulating hormone (TSH) alone as the best test to detect and monitor thyroid dysfunction, yet free thyroxine (FT4) and free triiodothyronine (FT3) are commonly ordered when not clinically indicated. Excessive testing can lead to added economic burden in an era of rising healthcare costs, while rarely contributing to the evaluation or management of thyroid disease.

    Objective: To evaluate our institution's practice in ordering thyroid function tests (TFTs) and to identify strategies to reduce inappropriate FT4 and FT3 testing. Read More

    Functional Abnormalities and Thyroid Nodules in Patients with End-stage Renal Disease.
    In Vivo 2017 Nov-Dec;31(6):1203-1208
    Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
    Background/aim: Clinical and subclinical hypothyroidism is more common in patients with end-stage renal disease (ESRD) than in the general population. Patients with ESRD with hypothyroidism are more susceptible to cardiovascular disease, with an increased risk of mortality than those with normal thyroid function. Moreover, these patients have higher incidence of benign and malignant nodules. Read More

    Impact of Hypothyroidism on Occurrence and Outcome of Acute Coronary Syndrome from the National Inpatient Sample.
    Am J Cardiol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania.
    Thyroid hormones have a profound effect on cardiovascular physiology. We utilized a large national inpatient database in the United States (National Inpatient Sample) to study hypothyroidism in relation to the prevalence of coronary heart disease (CHD) and its impact on outcomes (mortality, the length of stay, and hospitalization cost) in the acute coronary syndrome (ACS) subgroup of CHD patients. We found that although hypothyroidism has an increased association with CHD (odds ratio [OR] 1. Read More

    Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists.
    Endocr Connect 2017 Nov;6(8):726-730
    Department of Surgical SciencesCIR-Dental School, University of Turin, Turin, Italy.
    The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Read More

    Clinical Outcomes of Arthroscopic 360° Capsular Release for Idiopathic Adhesive Capsulitis in the Lateral Decubitus Position.
    Arthroscopy 2017 Oct 31. Epub 2017 Oct 31.
    Section of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.
    Purpose: To report outcomes after arthroscopic 360° capsular release in the lateral decubitus position for idiopathic glenohumeral adhesive capsulitis without manipulation under anesthesia.

    Methods: A retrospective case series of patients who underwent arthroscopic capsular release in the lateral decubitus position for idiopathic adhesive capsulitis with minimum 2-year follow-up was conducted. Patient demographics, preoperative range of motion (ROM), postoperative ROM, and the postoperative outcome scores, visual analog scale for pain, Single Assessment Numeric Evaluation, Simple Shoulder Test, and American Shoulder and Elbow Surgeons scores, were recorded. Read More

    High Fat Simple Carbohydrate diet intake induces Hypothalamic -Pituitary -Thyroid axis dysregulation in C57BL/6J male mice.
    Appl Physiol Nutr Metab 2017 Nov 3. Epub 2017 Nov 3.
    St Aloysius College ( Autonomous) Mangaluru, Karanataka, India, PG Studies and Research in Biotechnology , Light House Hill Road, , Mangaluru, Karnataka, India , 575 003 ;
    Given the association between subclinical hypothyroidism and metabolic syndrome (MetS), we wanted to explore if high fat simple carbohydrate (HFSC) diet affect hypothalamus-pituitary-thyroid axis. One month old male C57BL/6J mice were fed with Control (C) and HFSC (T) feed (n=18 each) respectively for 5 months. T3 showed a significant increase in T(13. Read More

    [Repeatability and variability of total T4 measurements at three German veterinary laboratories].
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2017 Nov 3;45(6). Epub 2017 Nov 3.
    Teresa Böhm, Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 München, E-Mail:
    Objective: To evaluate the reproducibility of serum testing for total thyroxine (T4) in three German laboratories.

    Materials And Methods: Serum was taken from 53 dogs with suspected hypothyroidism and divided into five aliquots. Three aliquots of each sample were marked with different names and sent to one laboratory (two aliquots simultaneously and one aliquot 1-3 days later). Read More

    SULPHUR-CONTAINING AMINO ACIDS METABOLISM IN EXPERIMENTAL HYPER- AND HYPOTHYROIDISM IN RATS.
    Georgian Med News 2017 Oct(271):96-102
    Vinnytsia National Pirogov Memorial Medical University; I. Horbachevsky Ternopil State Medical University, Ukraine.
    Hyper- and hypothyroidism are some of the most common endocrinopathies that cause many metabolic disorders including amino acids metabolism. However, a specific molecular mechanism of thyroid hormones influence on sulphur-containing amino acids metabolism has not been established. The aim of our research was to investigate experimentally the influence of thyroid gland functional state on the main enzymatic systems of sulphur-containing amino acids metabolism in liver and kidneys, the content of homocysteine, cysteine and H2S in blood. Read More

    Thyrotropin level and cognitive performance: Baseline results from the ELSA-Brasil Study.
    Psychoneuroendocrinology 2017 Oct 20;87:152-158. Epub 2017 Oct 20.
    Center for clinical and epidemiological research, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil; Department of Internal Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil.
    Background And Aims: The role of subtle thyroid alterations, such as subclinical thyroid disease and low/high serum thyrotropin (TSH) within the normal range, on cognitive decline is controversial. The aim of this study was to evaluate the association of serum TSH and subclinical thyroid dysfunction with performance on cognitive tests in a large sample of Brazilian middle-aged adults without overt thyroid disease.

    Methods: In this cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health, we excluded individuals aged 65 years and older, with overt thyroid dysfunction, prevalent stroke, in use of medications that affect thyroid function or that indicate neurologic diseases, and from Asian or indigenous ethnicity. Read More

    Primary hypothyroidism and isolated ACTH deficiency induced by nivolumab therapy: Case report and review.
    Medicine (Baltimore) 2017 Nov;96(44):e8426
    aDepartment of Endocrinology, Huashan Hospital North bDepartment of Endocrinology, Huashan Hospital, Fudan University, Shanghai, China.
    Rationale: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system.

    Patient Concerns: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Read More

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