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Dermatol Ther (Heidelb) 2022 Jun 25. Epub 2022 Jun 25.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, 37 Guo-Xue-Xiang, Chengdu, 610041, China.

Introduction: Infantile hemangioma (IH) is the most common benign tumor in infancy, but information about its pathogenesis is limited. The aim of this study was to determine maternal and perinatal risk factors for IH.

Methods: A total of 1033 IH patients were enrolled in the study between 2017 and 2020. Read More

Ann Clin Biochem 2022 Jun 24:45632221112654. Epub 2022 Jun 24.

Blood Sciences3237Epsom and Saint Helier University Hospitals NHS Trust.

Background: Neonatal congenital hypothyroidism screening is performed by measuring thyroid-stimulating hormone (TSH) in a dried blood spot (DBS) sample, whereas acquired hypothyroidism uses serum TSH. There is no established DBS TSH reference interval, but knowing this is useful, as some patients cannot tolerate venepuncture, so DBS collection is seen as an acceptable alternative. The aim of this study was to establish DBS TSH reference intervals in adults and neonates (day 5-8), and determine the relationship between serum and DBS TSH. Read More

West Afr J Med 2022 Jun;39(6):603-608

Department of Community Medicine, College of Medical Sciences, Abubakar Tafawa Balewa University, Bauchi, Nigeria.

Background: Congenital hypothyroidism is one of the most common preventable causes of mental retardation and clinical manifestations are often subtle or absent at birth and hence the need for screening. Implementation of newborn screening requires local normative values.

Objectives: To determine the normative values of cord Thyroid Stimulating Hormone (TSH) among term babies in Bauchi, Northeast Nigeria and compare it with that from other centers in Nigeria. Read More

Pediatr Nephrol 2022 Jun 24. Epub 2022 Jun 24.

Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Sihhiye, 06100, Ankara, Turkey.

Background: Recently, recessive mutations in SGPL1 (sphingosine-1-phosphate lyase), which encodes the final enzyme of sphingolipid metabolism, have been reported to cause steroid-resistant nephrotic syndrome, adrenal insufficiency, and many other organ/system involvements. We aimed to determine the clinical and genetic characteristics, and outcomes in patients with SGPL1 mutations.

Methods: The study included 6 patients with bi-allelic SGPL1 mutation. Read More

J Feline Med Surg 2022 Jun 24:1098612X221104743. Epub 2022 Jun 24.

Animal Endocrine Clinic, New York, NY, USA.

Objectives: Although radioiodine (I) is the treatment of choice for feline hyperthyroidism, I-dosing protocols commonly induce iatrogenic hypothyroidism and expose azotaemia. A recently reported patient-specific I dosing algorithm minimised the risk of I-induced hypothyroidism and azotaemia, while maintaining high cure rates. The aim of the study was to report results of I treatment in a European population of hyperthyroid cats using this patient-specific dosing algorithm. Read More

Cancer Med 2022 Jun 24. Epub 2022 Jun 24.

Department of Endocrinology and Metabolism, Rigshospitalet, Copenhagen, Denmark.

Introduction: Breast cancer (BC) is a common type of cancer in women. Advances in therapy options have resulted in higher overall survival rates but side effects of cancer treatment are increasingly in the spotlight. The beneficial effects of anti-oestrogen therapy with tamoxifen and letrozole in the prevention of BC recurrence are well documented. Read More

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):432-439

Torbat Heydariyeh University of Medical Sciences, Neuroscience Research Center, Torbat Heydariyeh, Iran.

Background: An increasing number of studies suggest that hypothyroidism may lead to hepatorenal toxicity. This study examined whether thymoquinone (TQ), the main active constituent, could prevent the detrimental influences of hepatorenal toxicity of hypothyroidism during the juvenile period in rats.

Methods: The male rats were randomly divided into four groups (n = 7), including control, propylthiouracil (PTU), PTU-TQ 5 mg/kg, and PTU-TQ 10 mg/kg. Read More

Int J Gen Med 2022 17;15:5681-5691. Epub 2022 Jun 17.

Medical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: COVID-19 (SARS-CoV-2/2019-nCoV) is now a major public health threat to the world. Olfactory dysfunctions (ODs) are considered potential indicating symptoms and early case identification triaging for coronavirus disease 2019 (COVID-19). The most common reported comorbidities are diabetes mellitus, chronic lung disease, and cardiovascular disease. Read More

Cureus 2022 May 20;14(5):e25153. Epub 2022 May 20.

Department of General Internal Medicine, Kobe University Hospital, Kobe, JPN.

A 76-year-old man presented with a four-month history of progressive bilateral lower limb muscle weakness and dysesthesia. The patient had extravascular volume overload, and laboratory findings confirmed hypothyroidism, renal dysfunction, and chronic inflammation. Serum protein and immunofixation electrophoresis revealed biclonality of immunoglobulin A (IgA)-kappa and IgA-lambda, which was attributed to chronic inflammation. Read More

Medicina (Kaunas) 2022 May 26;58(6). Epub 2022 May 26.

Clinical Epidemiology and Clinical Statistic Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

: There is a lack of data regarding hormonal metabolic abnormalities resulting from the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), a commonly used chemotherapy in diffuse large B-cell lymphoma (DLBCL). This study aimed to determine the incidence of hormonal and metabolic changes after R-CHOP therapy. : This prospective cohort study initially included 17 DLBCL patients. Read More

J Clin Med 2022 Jun 16;11(12). Epub 2022 Jun 16.

Assistance Publique-Hôpitaux de Paris Nord, Département Médico-Universitaire (DMU) INVICTUS, Département de Médecine Interne, Hôpital Lariboisière, INSERM UMRS-1144, Université de Paris Cité, 75010 Paris, France.

Background: Increased knowledge of the pharmacokinetic characteristics of orally administered levothyroxine (L-T) has improved individualization of dosing regimens. However, up to 40-45% of patients, depending on the leading cause of hypothyroidism, are still over- or, more often, undertreated. Unintentional non-adherence to L-T replacement therapy includes all situations of unintended drug-drug and drug-food interactions as well as fasting conditions that are not necessarily respected by patients. Read More

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Ciudad de Mexico 04530, Mexico.

Eighty-five percent of the studies of patients with congenital hypothyroidism (CH) treated with Levothyroxine (L-T) report neuropsychological sequelae throughout life. In neonates and infants, there is a deficit in sensorimotor skills (impaired balance). In preschool and elementary school children and adolescents, there are alterations in intellectual quotient (low scores), language (delayed phonological acquisition), memory (visual, verbal, visuospatial, visuoconstructive, autobiographical, and semantic), sensorimotor skills (impaired fine and gross motor control), and visuoconstructive-visuospatial domain (low scores in spatial location, block design, and object assembly). Read More

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Pharmacology-Clinical Pharmacology Unit, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, 11527 Athens, Greece.

Hypothyroidism in patients with solid non-thyroid cancer is a tantalizing entity, integrating an intriguing thyroid hormones (THs)-cancer association with the complexity of hypothyroidism itself. The present narrative review provides a comprehensive overview of the clinical relevance of hypothyroidism in solid non-thyroid cancer. Hypothyroidism in patients with solid non-thyroid cancer is reminiscent of hypothyroidism in the general population, yet also poses distinct challenges due to the dual role of THs in cancer: promoting versus inhibitory. Read More

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

Hashimoto's thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism, in which damage to the thyroid gland occurs due to the infiltration of lymphocytes. It is characterized by increased levels of antibodies against thyroid peroxidase and thyroglobulin. In this review, we present the metabolic profile, the effectiveness of micronutrient supplementation and the impact of dietary management in patients with HT. Read More

Pediatr Nephrol 2022 Jun 23. Epub 2022 Jun 23.

Department of Nephrology, Klinikum Stuttgart - Katharinenhospital, Stuttgart, Germany.

Patients with non-dialysis-dependant chronic kidney disease (NDD-CKD) and dialysis-dependant chronic kidney disease (DD-CKD) frequently also suffer from thyroid disorders, especially hypothyroidism which is found two to five times more often among them compared to the general population. Emerging research has illustrated the potential prognostic implications of this association as NDD-CKD and DD-CKD patients with hypothyroidism have been shown to have higher mortality rates, and treatment of subclinical hypothyroidism in NDD-CKD patients has been reported to attenuate the decline of glomerular filtration rate over time. This review illustrates the bidirectional, multi-layered interplay between the kidneys and the thyroid gland explaining how pathologies in one organ will affect the other and vice versa. Read More

Metabolites 2022 May 24;12(6). Epub 2022 May 24.

Department of Medicine, Division of Endocrinology, Georgetown University, Washington, DC 20007, USA.

We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration. In secondary analyses, we measured 3,5-T2 and 3-T1AM concentrations in stored samples from two clinical trials. In 12 healthy volunteers, THs and metabolites were documented for 96 h after a single dose of 50 mcg liothyronine. Read More

Thyroid 2022 Jun 23. Epub 2022 Jun 23.

The University of Hong Kong, 25809, Department of Pharmacology and Pharmacy, Hong Kong, Hong Kong;

Background: Thyroid dysfunction has been observed among some patients with COVID-19. It is unclear whether SARS-CoV-2 infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits [including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease (AITD)] and three continuous traits of thyroid hormones [including thyroid-stimulating hormone (TSH) and free thyroxine (FT4) within reference range, and TSH in full range]. Read More

Endocr J 2022 Jun 22. Epub 2022 Jun 22.

Department of Diabetes, Endocrinology, and Hematology, Dokkyo Medical University Saitama Medical Center, Saitama 343-8555, Japan.

Subclinical thyroid dysfunction is defined by serum thyroid-stimulating hormone (TSH) levels either greater or less than the reference range with normal thyroxine (T4) concentrations, and consists of subclinical hypothyroidism (SCH) and subclinical hyperthyroidism (SCHyper). For the proper diagnosis of SCH, it is most important to be able to correctly evaluate the serum TSH levels, which have numerous unique characteristics. We also need to be versed in TSH harmonization, which was recently launched world-wide. Read More

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Division of Endocrine Surgery, Department of Gastroenterologic, Endocrine-Metabolic and Nephro-Urologic Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Parathyroid cysts (PCs) are rare benign lesions representing between the 0.08% and the 0.34% of the neck masses going on surgery. Read More

MMW Fortschr Med 2022 Jun;164(12):18

Freier Medizinjournalist, Possenhofenerstr. 24, 82302, Starnberg, Germany.

AJR Am J Roentgenol 2022 Jun 22. Epub 2022 Jun 22.

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115.

On March 30, 2022, the U.S. FDA issued a drug safety communication recommending that infants and young children "through three years of age" undergo monitoring of thyroid function within three weeks of intravascular administration of iodine-based contrast media. Read More

Ann Geriatr Med Res 2022 May 18. Epub 2022 May 18.

Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.

Background: We investigated the prevalence and metabolic features of two definitions of multiple sclerosis (MS) between older patients with chronic thyroiditis treated with levothyroxine (LT4) and controls. We also assessed the ability of both criteria to predict cardiovascular (CV) risk.

Methods: This cross-sectional, retrospective study included individuals aged ≥60 years who attended a geriatric outpatient clinic between January 2015 and December 2018. Read More

Int J Cardiol 2022 Jun 18. Epub 2022 Jun 18.

Institute for Pathophysiology West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany. Electronic address:

Background: In patients undergoing interventional or surgical coronary revascularization, subclinical hypothyroidism is common and associated with worse outcome, including the need for postoperative inotropic support. In isolated rat hearts with global ischemia/reperfusion, exogenous triiodothyronine (T3) reduces infarct size. Aim of this study was, to investigate whether or not exogenous T3 protects human myocardium from ischemia/reperfusion injury. Read More

Eur J Contracept Reprod Health Care 2022 Jun 21:1-5. Epub 2022 Jun 21.

3rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Purpose: The authors discuss the need for newborn screening in the context of the migration policy of the European Union, and particularly, the European Asylum, Migration and Integration Fund.

Methods: The authors searched scholarly databases (Pubmed, Scopus, Google scholar) and grey literature (LexEuropa, Policy reports) to identify original peer-reviewed research examining the migration to the European Union and the provision of healthcare to infants born to refugees and immigrant mothers. Resources in language different from English, French, German and Greek were not taken into consideration. Read More

Curr Pharm Des 2022 Jun 20. Epub 2022 Jun 20.

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

Thyroid hormones (TH) have a significant impact on cellular oxidative metabolism. Besides that, they maintain vascular homeostasis by positive effects on endothelial and vascular smooth muscle cells. Subclinical (SCH) and clinical (CH) hypothyroidism influences target organs by changing their morphology and function and impaired blood and oxygen supply induced by accelerated atherosclerosis. Read More

Endocr Pract 2022 Jun 17. Epub 2022 Jun 17.

Hebrew University, Hadassah Medical School, Jerusalem, Israel; Endocrinology, Diabetes and Metabolism Institute, Kaplan Medical Center, Rehovot, Israel.

Objective: Post-hemithyroidectomy women are at increased risk for gestational subclinical hypothyroidism. Therefore, the American Thyroid Association (ATA) recommends increased thyroid function surveillance for this subgroup of pregnant women. The Purpose of this study was to evaluate the frequency of thyroid function surveillance during pregnancy in post-hemithyroidectomy women, and to evaluate the adherence to the 2017 ATA guidelines and its possible impact since being published, on thyroid function surveillance rates. Read More

Gynecol Endocrinol 2022 Jun 20:1-5. Epub 2022 Jun 20.

Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy.

Background: Graves' disease occurrence during pregnancy is not a frequent event, showing an incidence of 0.2-0.4% in unselected pregnant women. Read More

Ann Otol Rhinol Laryngol 2022 Jun 20:34894221098471. Epub 2022 Jun 20.

Department of Family and Community Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Objectives: The purpose of this study was to explore adherence to the American Cancer Society (ACS) Head and Neck Cancer (HNC) Survivorship Care Guideline and their outlined 33 recommendations among posttreatment HNC survivors.

Methods: A bi-institutional, retrospective, nested cohort study of mucosal or salivary gland HNC survivors diagnosed in 2018 was designed. Guideline adherence was assessed via retrospective chart review between 0 and 13 months after completion of oncologic treatment according to 4 categories: (1) problem assessed, (2) problem diagnosed, (3) management offered; (4) problem treated. Read More

Clin Exp Hypertens 2022 Jun 20:1-9. Epub 2022 Jun 20.

Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran.

Hypothyroidism disturbs redox homeostasis and takes part in cardiovascular system dysfunction. Considering antioxidant and cardio-protective effects of PPAR-γ agonists including pioglitazone (POG) and rosiglitazone (RSG), the present study was aimed to determine the effect of POG or RSG on oxidants and antioxidants indexes in the heart and aorta tissues of Propylthiouracil (PTU)-induced hypothyroid rats.

Materials And Methods: The animals were divided into six groups: (1) Control; (2) propylthiouracil (PTU), (3) PTU-POG 10, (4) PTU-POG 20, (5) PTU-RSG 2, and (6) PTU-RSG 4. Read More