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J Clin Sleep Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School -Baystate, Springfield, Massachusetts.

Study Objectives: To describe sex, age and body mass index (BMI) differences in comorbidities and polysomnography (PSG) measures, categorized using three different apnea-hypopnea index (AHI) criterion, in sleep clinic patients with mild obstructive sleep-disordered breathing (SDB).

Methods: A retrospective cohort of 305 (64% female) adult sleep clinic patients who underwent full night in-laboratory polysomnography diagnosed with mild SDB and prescribed positive airway pressure (PAP). Effects of sex, age and BMI on comorbidities and PSG measures including rates of AHI defined by ≥3% desaturations (AHI), with arousals (AHI), by ≥4% desaturations (AHI) and by respiratory disturbance index (RDI) were evaluated. Read More

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.

Background: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone, with iodine deficiency remains the foremost cause. It is more common in women with increasing incidence in the elderly. The manifestations of hypothyroidism results from the hypometabolism in the body at cellular level and affects all organs. Read More

Int J Clin Res Trials 2020 1;5(1). Epub 2020 Jun 1.

Department of Medicine, SUNY-Downstate Health Science University, Brooklyn, New York, USA.

Heart Failure (HF) is a major public health problem and a major cause of morbidity and mortality worldwide. Thyroid hormones (TH) have multiple effects on the heart and cardiovascular system. In recent years, studies have shown that hypothyroidism, including subclinical hypothyroidism, is associated with an increased risk for developing and worsening of HF. Read More

Best Pract Res Clin Endocrinol Metab 2020 Jun 18:101439. Epub 2020 Jun 18.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228. Electronic address:

Overt hypothyroidism is a common endocrine disorder affecting 1-2% of women of reproductive age. Optimizing treatment in pregnant women with overt hypothyroidism can reduce adverse fetal and maternal outcomes. Ideally, women who are known to have a history of hypothyroidism or those with risk factors for becoming hypothyroid, should have adequate preconception care to ensure euthyroidism from the onset of pregnancy, with a TSH target of below 2. Read More

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):308-318. Epub 2020 Jun 24.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The aim of this study was to determine the associations between subclinical hypothyroidism (SCH) and long-term cardiovascular outcomes after coronary artery bypass grafting (CABG) or heart valve surgery (HVS).

Methods: We retrospectively reviewed and compared all-cause mortality, cardiovascular mortality, and cardiovascular events in 461 patients who underwent CABG and 104 patients who underwent HVS.

Results: During a mean±standard deviation follow-up duration of 7. Read More

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):132-136. Epub 2020 Jun 30.

Division of Pediatric Endocrinology, Kyungpook National University Children's Hospital, Daegu, Korea.

Alport syndrome (AS) is a rare genetic disorder that causes progressive nephritis and is more common among males. Studies have reported an association between thyroid antibodies and hypothyroidism in patients with AS, but the relevance of this relationship is under debate. Prolonged untreated hypothyroidism induces short stature, abnormal pubertal development, and various other symptoms. Read More

Cardiovasc Hematol Agents Med Chem 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandam Palayam Post, Erode, Tamil Nadu. India.

Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. Read More

J Clin Endocrinol Metab 2020 Jul 2. Epub 2020 Jul 2.

Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago IL.

Context: It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain symptomatic, but why patients are susceptible to this condition, why symptoms persist and what is the role of combination therapy with LT4 and liothyronine (LT3), are questions that remain unclear. Here we explore evidence of abnormal thyroid hormone (TH) metabolism in LT4-treated patients, and offer a rationale for why some patients perceive LT4 therapy as a failure.

Evidence Acquisition: The review is based on a collection of primary and review literature gathered from a PubMed search of hypothyroidism, levothyroxine, liothyronine, and desiccated thyroid extract, among other keywords. Read More

Int J Endocrinol 2020 13;2020:2698627. Epub 2020 Jun 13.

Tecnológico Nacional de México/IT de Oaxaca, Oaxaca 68030, Mexico.

The debate regarding the cutoff point in the treatment of patients with subclinical hypothyroidism (Shypo) is ongoing. Generally, two different groups are identified for treatment by levels of 10 and 20 mIU/L. Nevertheless, the question remains, "what cutoff point should be chosen?" We have written a selective nonsystematic review focused on the 97. Read More

BMJ Open 2020 Jul 1;10(7):e033866. Epub 2020 Jul 1.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, UK.

Objectives: To compare the patterns of 18 physical and mental health comorbidities between people with recently diagnosed type 2 diabetes (T2D) and people without diabetes and how these change by age, gender and deprivation over time between 2004 and 2014. Also, to develop a metric to identify most prevalent comorbidities in people with T2D.

Design: Population-based cohort study. Read More

Surg Obes Relat Dis 2020 May 22. Epub 2020 May 22.

Clinica Medica 3, Department of Medicine - DIMED, University-Hospital of Padova, Padova, Italy.

J Assoc Physicians India 2020 May;68(5):13-17

SMS Medical College and Attached Group of Hospital, Jaipur, Rajasthan.

Background: The novel coronavirus (Covid-19) continues to wreck havoc across China, European countries, USA and now seems to gain a strong foothold in India. The aim of this report is to describe the clinical profiles of these Covid-19 infected patients admitted in Sawai Mansingh Hospital(S.M. Read More

JAMA Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Int J Gen Med 2020 15;13:305-310. Epub 2020 Jun 15.

Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Early diagnosis and management of subclinical hypothyroidism (SCH) are important to avoid the risk of developing overt hypothyroidism. This study aimed to evaluate patients with subclinical hypothyroidism (SCH), in regard to their biochemical characteristics, and ultrasound features, and factors associated with initiating treatment for this condition.

Methods: This was a retrospective study, which reviewed the data of patients who visited the Endocrinology clinic of a tertiary hospital in Jordan, King Abdullah University Hospital. Read More

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Heamatology, Hopital Erasme, Brussels, Belgium.

TAFRO (thrombocytopenia, anasarca, fever, reticulin myelofibrosis or renal dysfunction and organomegaly) syndrome is a systemic inflammatory disease characterised by thrombocytopenia, anasarca, fever or inflammatory syndrome, reticulin myelofibrosis or renal dysfunction and organomegaly. It was first described as a subtype of idiopathic multicentric Castleman disease. Here, we report the case of a 42-year-old woman presenting with thrombocytopenia, anasarca, inflammatory syndrome, renal insufficiency, reticulin myelofibrosis at bone marrow biopsy and cervical and axillary lymph nodes. Read More

Eur J Cancer 2020 Jun 27;135:150-158. Epub 2020 Jun 27.

Department of Medicine I, Division of Oncology, Medical University of Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Austria. Electronic address:

Background: Several preclinical and epidemiologic studies have indicated tumour-promoting effects of thyroid hormones (THs). However, very limited knowledge exists on the prognostic impact of thyroid function in metastatic cancer.

Methods: We compiled a discovery cohort of 1692 patients with newly diagnosed brain metastases (BMs) of solid cancers treated at the Medical University of Vienna and an independent validation cohort of 191 patients with newly diagnosed BMs treated at the University Hospital Zurich. Read More

J Assoc Physicians India 2020 Jul;68(7):34-42

Department of General Medicine, SMS Medical College and Jaipur, Rajasthan.

Purpose: The present study was undertaken to investigate and quantify the severity of COVID-19 infection on high-resolution chest computed tomography (CT) and to determine its relationship with clinical parameters. This study also aimed to see CT changes with clinical recovery or progression of disease.

Materials And Methods: In an attempt to provide extensive information pertaining to clinical and radiological characteristics of COVID-19, the present study was undertaken in 80 hospitalized patients. Read More

Saudi Med J 2020 Jul;41(7):703-708

Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the incidence of newborn screening (NBS) disorders and to study the key performance indicators of the program.

Methods: This retrospective single-center study enrolled all infants who underwent NBS from January 2012 to December 2017 at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. We screened 17 NBS disorders. Read More

Thyroid 2020 Jun 29. Epub 2020 Jun 29.

The first affiliated hospital of Kunming medical university, No. 295 Xchang Rd., Kunming, China, 650032;

Background: Maternal subclinical hypothyroidism (SCH) is a risk factor for adverse pregnancy outcomes. However, it is still unclear whether SCH affects male fertility. The aim of this study was to determine the association between paternal SCH and clinical outcomes after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Read More

Eur J Cancer 2020 Jun 26;135:211-220. Epub 2020 Jun 26.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Aim: Antibodies to programmed death-1 receptor and its ligand (anti-PD-1/PD-L1) produce durable responses in many cancers. However, the long-term effects of anti-PD-1/PD-L1 blockade are not well defined. We identified the toxicities, health outcomes and health-related quality of life (HRQoL) amongst long-term survivors treated with anti-PD-1/PD-L1. Read More

Ter Arkh 2019 Oct 15;91(10):135-138. Epub 2019 Oct 15.

Sechenov First Moscow State Medical University (Sechenov University).

Central hypothyroidism is a rare cause of hypothyroidism, consequence of various disorders affecting pituitary (secondary) or hypothalamus (tertiary hypothyroidism). Difficulties in the diagnosis and management of patients are due to the nontypical clinical picture, frequent combination with impaired function of other pituitary hormones, difficulties in laboratory assessment in high TSH levels or low - normal T4 free levels. Diagnosis is based on a confirmed decrease in the level of free T4 with a low or normal level of TSH. Read More

J Clin Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand.

Background: It is unclear whether newborns with mild TSH elevation (mTSHe) are at risk of neurocognitive impairment. We assessed whether mTSHe at birth persists during childhood and compared neurocognitive functioning to siblings.

Methods: This study encompassed children born in the Auckland region with a newborn screen TSH level 8-14 mIU/L blood, aged 6. Read More

ACS Appl Mater Interfaces 2020 Jun 29. Epub 2020 Jun 29.

Although luminescence spectroscopy has been a promising sensing technology with widespread applications in point-of-care diagnostics and chem-bio detection, it fundamentally suffers from low signal collection efficiency, considerable background noise, poor photostability, and intrinsic omnidirectional emission properties. In this regard, surface plasmon-coupled emission (SPCE), a versatile plasmon-enhanced detection platform with > 50 % signal collection efficiency, high directionality, and polarization has previously been explored to amplify the limit of detection of desired analytes. However, high Ohmic loss in metal-dependent plasmonic platforms has remained an inevitable challenge. Read More

Endocr Regul 2020 Apr;54(2):126-132

1st Department of Psychiatry, Pavol Jozef Safarik University Faculty of Medicine, Kosice, Slovak Republic.

Objectives: The purpose of the present paper is to propose and introduce novel biomarkers of autoimmune polyendocrine syndromes that are relevant to the early diagnosis and optimal medical management of the patients who already suffer from type 1 diabetes mellitus.

Methods: We hypothesize and demonstrate on a case study that various organ-specific autoimmune endocrinopathies can result in lowered basal insulin requirements, leading to unexplained hypoglycemia.

Results: It can be hypothesized that hypothyroidism in patients with type 1 diabetes mellitus may deteriorate glycemic control and can lead to an increased rate of hypoglycemia, particularly the overnight and morning hypoglycemia. Read More

Endocr Regul 2020 Apr;54(2):109-118

Zaporozhye State Medical University, Zaporizhzhia, Ukraine.

Objective: Thyroid hormones have important actions in the adult brain. They regulate genes expression in myelination, differentiation of neuronal and glial cells, and neuronal viability and function.

Methods: We used the pathway-specific real-time PCR array (Neurotrophins and Receptors RT2 Profiler PCR Array, QIAGEN, Germany) to identify and verify nerve impulse transmission pathway-focused genes expression in peripheral white blood cells of patients with postoperative hypothyroidism, hypothyroidism as a result of autoimmune thyroiditis (AIT) and AIT with elevated serum an anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies. Read More

Cureus 2020 May 25;12(5):e8275. Epub 2020 May 25.

Internal Disease, Batman District State Hospital, Batman, TUR.

This case reported here was a 27-year-old female patient, and she had no chronic disease other than hypothyroidism. She was brought to the ER with complaints of fever, chills, weakness, and hyponatremia. She has been diagnosed with brucellosis using a serum tube agglutination test (STAT). Read More

Eur Endocrinol 2020 Apr 4;16(1):32-39. Epub 2020 Feb 4.

Bharti Hospital, Karnal, India.

Cancer immunotherapy and targeted therapy, though less toxic than conventional chemotherapy, can increase the risk of thyroid dysfunction. Immune checkpoint inhibitors render the cancer cells susceptible to immune destruction, but also predispose to autoimmune disorders like primary hypothyroidism as well as central hypothyroidism secondary to hypophysitis. Tyrosine kinase inhibitors act by blocking vascular endothelial growth factor receptors and their downstream targets. Read More

Case Rep Ophthalmol 2020 May-Aug;11(2):212-216. Epub 2020 Jun 9.

Department of Physiology, Faculty of Medical Science, Anton de Kom University of Suriname, Paramaribo, Suriname.

Chalazia are chronic inflammatory disorders of the Meibomian glands of the eyelids that can present at any age. Although the exact cause is still obscure, they are often associated with retention of lipids in these sebaceous glands, infections, or disturbances in the balance of sex hormones. The complications of the disease may vary from little discomfort to reduced vision. Read More

Endocrinol Diabetes Nutr 2020 Jun 24. Epub 2020 Jun 24.

Departamento de Anatomía Humana, Facultad de Ciencias de la Salud, Universidad Católica de Murcia, Guadalupe de Maciascoque, Murcia, España.

Objective: Radioiodine (I) is an established modality of definitive treatment of hyperthyroidism. In spite of the vast experience available, there are still several aspects to be clarified, such as whether fixed or calculated doses should be used. The aim of this study was to assess whether efficacy of this treatment could be improved by implementing a simple dosimetric calculation method including ultrasonographic estimation of thyroid volume and a single measurement of 24-hour I thyroid uptake. Read More

J Clin Endocrinol Metab 2020 Aug;105(8)

Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK.

Objective: To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.

Design: Observational cohort study.

Setting: A total of 49 hospitals across the United Kingdom between 2011 and 2016. Read More

J Clin Psychol 2020 Jun 27. Epub 2020 Jun 27.

Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw, Warsaw, Poland.

Objective: As demonstrated in a pilot study, hypothyroidism has a highly stressful impact on some areas of functioning. This study aims to evaluate the connection between illness-related beliefs (IRBs) and the impact of hypothyroidism on fertility and close relationships, which were the strongest stressors, and the level of depressive, anxiety, and anger symptoms.

Methods: Two hundred and thirteen women being treated for hypothyroidism took part in an online survey and completed the modified Hospital Anxiety and Depression Scale, Hypothyroidism Symptoms Severity rating scales, and a measure of IRBs. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20838

Center of Neonatal Screening.

Congenital hypothyroidism (CH) is one of the most common neonatal endocrine diseases. This retrospective cohort study aimed to identify the potential perinatal risk factors for CH and to differentiate between transient and permanent CH (TCH and PCH, respectively) as well as determine their prevalence in a southeastern Chinese population.This study was based on an 18-year surveillance of a neonatal CH screening program in a large tertiary hospital. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20778

Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.

Background: Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage this entity properly. Read More

Ann Agric Environ Med 2020 Jun 2;27(2):184-193. Epub 2019 Oct 2.

Nencki Institute of Experimental Biology PAN, Poland.

Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms. Read More

J Contemp Dent Pract 2020 Apr 1;21(4):410-415. Epub 2020 Apr 1.

Department of Periodontics and Oral Implantology, Sree Mookambika Institute of Dental Sciences and Research, Tamil Nadu, India.

Aim: The aim of this article was to determine the effect of nonsurgical periodontal therapy on clinical parameters and also to evaluate serum level of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in chronic periodontitis patients with and without hypothyroidism.

Materials And Methods: Subjects were 40 female patients (20 systemically healthy subjects with chronic periodontitis and 20 subjects with hypothyroidism and chronic periodontitis). Clinical parameters like plaque score, gingival score, gingival recession, probing pocket depth, and clinical attachment level were recorded at baseline and 4 weeks after nonsurgical periodontal therapy. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936808

University of Arizona, Phoenix, AZ, USA.

Tyrosine kinase inhibitors (TKIs) have been used in the treatment of multiple types of cancer. Pazopanib is one of the TKIs and is considered a first-line treatment for adult patients with metastatic renal cell carcinoma. Many endocrine-related adverse effects have been noted with the use of TKIs including hypothyroidism, vitamin D deficiency, altered bone density, secondary hyperparathyroidism, abnormal glucose metabolism, gynecomastia, and hypogonadism. Read More

J Endocrinol Invest 2020 Jun 24. Epub 2020 Jun 24.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Purpose: To assess the success rate of first dose radioiodine for treatment of hyperthyroidism in children and adolescent.

Methods: This is a retrospective data analysis of children and adolescent with hyperthyroidism who received radioiodine (RAI) therapy from January 2013 to December 2017. Age, gender, family history of hyperthyroidism, duration of anti-thyriod drugs (ATDs) treatment, rapid turnover status, 2 h and 24 h I-131 radioiodine uptake (RAIU), thyroid volume, and treatment dose were also analyzed. Read More

Med Klin Intensivmed Notfmed 2020 Jun 24. Epub 2020 Jun 24.

Klinik für Allgemeine Innere Medizin, Endokrinologie, Diabetologie, Infektiologie, Klinikum Bielefeld Mitte, Bielefeld, Deutschland.

Background: Iodine-induced thyroid dysfunctions are, despite their rare occurrence, important clinical syndromes. Their immediate recognition can avoid serious consequences. Important triggers can be iodine-containing contrast agents, amiodarone or iodine-containing disinfectants. Read More

Front Endocrinol (Lausanne) 2020 5;11:309. Epub 2020 Jun 5.

Pediatric Endocrine Institute, Ha'Emek Medical Center, Afula, Israel.

Autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in children. The natural outcome of AIT in childhood has been reported previously however follow-up duration is generally short and results variable. To characterize clinical and biochemical findings at presentation of AIT, evaluate long-term outcomes and assess which factors at presentation predict evolution over time. Read More

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

A Boelen, Endocrinology Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC - Locatie AMC, Amsterdam, Netherlands.

Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed, if necessary, by thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG) measurement enabling detection of both CH-T and CH-C. A calculated T4/TBG ratio serves as an indirect measure for free T4. Read More

Eur J Endocrinol 2020 Aug;183(2):R13-R28

Department of Mother and Child, Paediatric Endocrinology Unit, University Hospital 'Federico II', Naples, Italy.

Subclinical hypothyroidism (SH) is biochemically defined as serum TSH levels above the upper limit of the reference range in the presence of normal free T4 (FT4) concentrations. While there is a general agreement to treat subjects with serum TSH levels above 10 mU/L, the management of mild form (TSH concentrations between 4.5 and 10 mU/L) is still a matter of debate. Read More

Adv Med Sci 2020 Jun 21;65(2):332-337. Epub 2020 Jun 21.

Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Purpose: We aimed to determine the volume of the thyroid gland in full-term neonates born to hypothyroid mothers as compared with full-term infants born to healthy mothers and to investigate the association between levothyroxine doses and the thyroid volume of neonates.

Materials And Methods: This is single center prospective observational study of 245 full-term neonates (96 from hypothyroid and 149 from healthy mothers). Ultrasound examination in both longitudinal and transverse projections was used to calculate the thyroid volume applying the ellipsoid formula. Read More

Toxicol Rep 2020 11;7:730-742. Epub 2020 Jun 11.

Department of Pharmacognosy, SVKM's NMIMS, School of Pharmacy & Technology Management Mukesh Patel Technology Park, Babulde, Mumbai-Agra Highway, Shirpur, India.

Hypothyroidism is the most frequent consequence of the interaction of a large variety of drugs, environmental pollutants and industrial chemicals with the thyroid gland. It is associated with diminished endocrine function which may lead to hyperlipidemia, diabetes, Alzheimer's disease, weight gain, and other metabolic disorders. The present study evaluates the pro-thyroid activity of a bioactive fraction from a polyherbal teabag in rats with hypothyroidism induced by propylthiouracil. Read More

Adipocyte 2020 Dec;9(1):264-278

Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.

Adiposity is caused by an imbalance between energy intake and consumption. Promotion of the browning of white fat increases energy expenditure and could combat adiposity. Thyroid-stimulating hormone (TSH) has been confirmed to positively correlate with adiposity. Read More

J Gerontol A Biol Sci Med Sci 2020 Jun 6. Epub 2020 Jun 6.

Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.

Background: Fatigue often triggers screening for and treatment of subclinical hypothyroidism. However, data on the impact of levothyroxine on fatigue is limited and previous studies might not have captured all aspects of fatigue.

Method: This study is nested within the randomized, placebo-controlled, multicenter TRUST trial, including community-dwelling participants aged ≥65 and older, with persistent subclinical hypothyroidism (TSH 4. Read More

CMAJ 2020 Jun;192(22):E596-E602

Departments of Medicine (Yamamoto, Metcalfe, Nerenberg, Donovan), of Obstetrics and Gynecology (Yamamoto, Metcalfe, Nerenberg, Donovan), and of Pathology and Laboratory Medicine (Chin), Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Research Institute (Yamamoto, Metcalfe, Donovan), Calgary, Alta.; and Departments of Medicine and of Obstetrics and Gynecology (Khurana), University of Alberta, Edmonton, Alta.

Background: Screening in pregnancy for subclinical hypothyroidism, often defined as thyroid-stimulating hormone (TSH) greater than 2.5 mIU/L or greater than 4.0 mIU/L, is controversial. Read More

Am J Med Genet A 2020 Jun 23. Epub 2020 Jun 23.

Rare Diseases and Clinical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome, caused by alterations in a cluster of imprinted genes located within the chromosome region 11p15.5. Common clinical features are overgrowth, macroglossia, lateralized overgrowth, abdominal wall defects, neonatal hypoglycemia and an increased risk of embryonal tumors, such as hepatoblastomas. Read More

Endocrine 2020 Jun 22. Epub 2020 Jun 22.

Department of Public Health, University of Naples Federico II, Naples, Italy.

The universal applicability of levothyroxine (LT4) monotherapy for the treatment of hypothyroidism has been questioned in recent years. Indeed, it is now clear that about 10-15% of LT4-treated hypothyroid patients are dissatisfied with their treatment. It is plausible that this subset of hypothyroid patients may need T3 + T4 combined therapy to restore peripheral euthyroidism. Read More

Wien Med Wochenschr 2020 Jun 22. Epub 2020 Jun 22.

Institut für Nuklearmedizin, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

In healthy older people the metabolism of thyroid hormones is physiologically altered and can possibly even actively contribute to longevity. This should also be taken into consideration in the treatment of diseases of the thyroid and principally also for younger patients. For example, with progressing age comorbidities become more prevalent and especially in cardiovascular diseases, hyperthyroidism is less well tolerated, and should be treated more aggressively. Read More

Ren Fail 2020 Nov;42(1):572-579

Department of Nephrology, Toho University School of Medicine, Tokyo, Japan.

Major symptoms of progressive chronic kidney disease (CKD) are similar to those of hypothyroidism. Hidden symptoms of hypothyroidism underlying CKD are often observed in clinical practice. This study aimed to ascertain the frequency of hypothyroidism complicated by CKD, and to analyze factors impacting thyroid function. Read More