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Endocrinol Diabetes Metab Case Rep 2019 Mar 15;2019. Epub 2019 Mar 15.

Department of Internal Medicine F, Soroka University Medical Center, Beer Sheva, Israel.

A previously healthy 24-year-old female underwent an emergent caesarean section without a major bleeding described. During the first post-operative days (POD) she complained of fatigue, headache and a failure to lactate with no specific and conclusive findings on head CT. On the following days, fever rose with a suspicion of an obstetric surgery-related infection, again with no evidence to support the diagnosis. Read More

J Pediatr Endocrinol Metab 2019 Mar 15. Epub 2019 Mar 15.

Division of Pediatric Endocrinology, University Department of Pediatrics, CHU Liège, Liège, Belgium.

Background Neuroblastoma (NBL) is a child neoplasia affecting extracranial tissue of neuroectodermal origin. It accounts for 10% of solid malignancies in children and is characterized by a survival rate approaching 70%, confronting physicians with the emergence of an adult survivor population who have been previously exposed to surgery, cytotoxic drugs, radiation therapy or metaiodobenzylguanidine (MIBG) therapy. All these treatments potentially affect the endocrine system. Read More

J Neuroendocrinol 2019 Mar 15:e12707. Epub 2019 Mar 15.

Department of Neurology, University of Lübeck, Lübeck, Germany.

Background: Hypothyroidism is associated with memory impairments.

Objectives: The aim of this study was to evaluate the effects of partial withdrawal of levothyroxine on working memory tasks and brain function.

Methods: Fifteen subjects under long-term levothyroxine substitution due to complete hypothyroidism participated in this study. Read More

Endocrine 2019 Mar 14. Epub 2019 Mar 14.

Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.

Purpose: In DTC patients, 131-radioiodine therapy has routinely been used for many years for thyroid remnant ablation after thyroid surgery. To date, two different strategies can be used to achieve sufficient TSH stimulation on thyroid remnant: (I) Levo-thyroxine withdrawal or (II) rhTSH stimulation. The aim of our study was to compare the abdominal absorbed dose ratio between differentiated thyroid cancer patients who underwent thyroid remnant ablation after either L-T4 withdrawal or rhTSH stimulation. Read More

Mol Neurobiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.

A distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex and projecting to the dentate gyrus (DG) then to area CA3 and subsequently, area CA1 of the Ammon's horn. Each of these areas of the hippocampus has its own cellular structure and distinctive function. The principal neurons in these areas are granule cells in the DG and pyramidal cells in the Ammon's horn's CA1 and CA3 areas with a vast network of interneurons. Read More

J Clin Endocrinol Metab 2019 Mar 15. Epub 2019 Mar 15.

Marienklinik, Bolzano, Italy.

Context: Obesity is associated with hypothyroidism and goiter.

Objective: The aim of the study was to verify whether thyroid structure and function would improve, after weight loss.

Design And Patients: We evaluated 96 overweight/obese children, who showed an altered parenchymal pattern at thyroid ultrasound without circulating anti-thyroid antibodies. Read More

Sci Rep 2019 Mar 15;9(1):4662. Epub 2019 Mar 15.

U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Toxicity Assessment Division, Endocrine Toxicology Branch, Research Triangle Park, North Carolina, NC, 27711, USA.

Cortical heterotopias are clusters of ectopic neurons in the brain and are associated with neurodevelopmental disorders like epilepsy and learning disabilities. We have previously characterized the robust penetrance of a heterotopia in a rat model, induced by thyroid hormone (TH) disruption during gestation. However, the specific mechanism by which maternal TH insufficiency results in this birth defect remains unknown. Read More

Sci Rep 2019 Mar 14;9(1):4418. Epub 2019 Mar 14.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

The combined phenotype of thrombocytopenia accompanied by intellectual disability in patients with a de novo heterozygous mutation, i.e., p. Read More

Trends Cardiovasc Med 2019 Mar 5. Epub 2019 Mar 5.

School of Medicine, Athens University, Athens, Greece. Electronic address:

Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and normal free thyroid hormones, is associated with increased cardiovascular (CV) risk and mortality. Depending on the degree of such dysfunction, atherosclerosis, coronary artery disease, heart failure and cardiac arrhythmias, predominantly atrial fibrillation, characterize both disorders and increase CV and total mortality compared to euthyroid persons. There are some differences in the mechanisms involved in the increased CV risk incurred by each type of STD, with more traditional CV risk factors clustered in SHypo than in SHyper, while the role of the TSH or its absence thereof, together with the respective, even subtle, changes incurred in thyroid hormone concentrations, seem to adversely influence the CV system in both types of STD. Read More

JAMA Facial Plast Surg 2019 Mar 14. Epub 2019 Mar 14.

Division of Facial Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri.

Importance: Paramedian forehead flaps are commonly used to reconstruct facial defects caused by skin cancers. Data are lacking on the complications from this procedure, postoperative outcomes, and association of cancer diagnosis with rate of deep venous thrombosis (DVT).

Objectives: The primary objective was to determine complication rates after paramedian forehead flap reconstruction for defects resulting from resection of facial cancers; and the secondary objective was to determine patient factors and complications that are associated with readmission. Read More

Rev Prat 2018 May;68(5):e211-e218

Professeur émérite d'endocrinologie, université de Lille-2, 765, domaine de la Vigne, 59910 Bondues, France.

Rev Prat 2018 May;68(5):e210

Professeur émérite d'endocrinologie, université de Lille-2, 765, domaine de la Vigne, 59910 Bondues, France.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):60-63

Department Obstetrics & Gynaecology, Lady Reading Hospital, Peshawar, Pakistan.

Background: The objective of this study was to collect data of patients coming to us with primary amenorrhea. Finding the different causes of this problem and managing them accordingly with the help multidisciplinary team.. Read More

Intern Emerg Med 2019 Mar 13. Epub 2019 Mar 13.

Division of Endocrine and Metabolic Surgery, Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Some evidence suggests a relationship between thyroid dysfunction and uric acid (UA) metabolism, but the potential influential role of thyroid hormones on UA metabolism is still debated. This report was designed to evaluate the influential role of levothyroxine (L-T4) replacement therapy on circulating levels of UA in patients with recent onset post-thyroidectomy subclinical hypothyroidism. Circulating levels of thyroid hormones, UA and other metabolic parameters were assessed in 155 recently thyroidectomized patients (131 females, mean age 51. Read More

Case Rep Endocrinol 2019 5;2019:5986014. Epub 2019 Feb 5.

Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, Japan.

Refractory hypothyroidism is caused by decreased gut absorption, increased metabolism, and poor compliance. Previous studies suggested that the weekly oral, suppository, or intramuscular administration of levothyroxine (LT4) is an effective treatment for refractory hypothyroidism. However, limited information is currently available on treatment involving the weekly intravenous administration of LT4. Read More

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Graduate Program in Pathology, Universidade Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Brazil.

Objective: The aim of this study was to evaluate levothyroxine (LT4) replacement daily doses, considered clinical and biochemical appropriate, in patients with Central Hypothyroidism (CeH) and compare them with those adequate for patients with Primary Hypothyroidism (P-HYPO).

Methods: We included 53 patients with CeH and 57 with PH, matched by sex, age, weight and body mass index, followed in a Neuroendocrine Referral Center, in the period of one year. At the time of inclusion, all presented a stable and adequate dose of LT4 for at least three months, considering as adequate the dose associated with normal TSH levels and free T4 in P-HYPO patients, and free T4 levels in CeH patients. Read More

Arch Endocrinol Metab 2019 Feb;63(1):16-21

Department of Anesthesiology and Algology, Ataturk Research and Training Hospital, Izmir, Turkey.

Objective: In this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT).

Subjects And Methods: The study included 160 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto's thyroiditis and 86 euthyroid healty subjects. Serum glucose and lipid profile, insulin, HOMA, TSH, free T3, free T4, anti-thyroperoxidase and anti-thyroglobulin antibodies, homocysteine, apelin and irisin levels were measured in all study subjects. Read More

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Internal Medicine, Adıyaman University, Adıyaman, Turkey.

Introduction: Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature.

Materials And Methods: This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups. Read More

Int J Hematol 2019 Mar 12. Epub 2019 Mar 12.

Japan Association of Childhood Leukemia Study Group (JACLS), Suita, Japan.

Women are at high risk of hypergonadotropic hypogonadism after hematopoietic cell transplantation (HCT). Hypogonadism is universal after irradiation or busulfan. We hypothesized that reduced intensity conditioning (RIC) might protect ovarian function after HCT. Read More

S Afr J Physiother 2019 28;75(1):933. Epub 2019 Feb 28.

Faculty of Business and Economic Science, University of the Free State, South Africa.

Background: Pelvic organ prolapse (POP) is a multifactorial, poorly understood condition impacting quality of life (QOL). The pathology and aetiology might imply population-specific differences in domains of the International Classification of Function, Disability and Health (ICF). There is, however, a lack of research in this regard in South Africa. Read More

S Afr J Physiother 2019 14;75(1):472. Epub 2019 Feb 14.

Department of Economic and Business Science, University of the Free State, South Africa.

Background: There is little evidence on movement impairment of the abdominal and pelvic floor muscles (PFM) in women with pelvic organ prolapse (POP).

Objectives: The aim of this study was to determine the movement impairments and interactions between the PFM and abdominal muscles in POP.

Method: The PFM and abdominal muscles of 100 conveniently sampled South African women with POP were assessed by ultrasonography, electromyography (EMG), the PERFECT scale, Sahrmann scale and a Pressure Biofeedback Unit (PBU). Read More

World J Clin Cases 2019 Mar;7(5):663-667

Department of Anesthesiology, Shaoxing Central Hospital, Shaoxing 312000, Zhejiang Province, China.

Background: Empty sella syndrome is a condition in which the pituitary gland shrinks or flattens. Patients with empty sella syndrome often present with headache, hypertension, obesity, visual disturbances, cerebrospinal fluid (CSF) rhinorrhoea, or endocrine dysfunction. Herein, we report a rare case of empty sella syndrome discovered after the patient experienced postoperative hypotension and respiratory failure. Read More

J Pediatr Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Clinic of Pediatric Endocrinology, Altındağ/Ankara, Turkey.

Background The management options for Graves' disease in children are limited and there is controversy regarding optimal treatment. Remission rate with anti-thyroid drug (ATD) treatment in children is said to be lower than in adults. Definitive treatments are effective, but they often result in permanent hypothyroidism. Read More

Turk J Med Sci 2019 Mar 13;49(2). Epub 2019 Mar 13.

Background/aim: Graves’ disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism. Read More

Horm Metab Res 2019 Mar 12;51(3):145-156. Epub 2019 Mar 12.

Department of Endocrinology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4), programed cell death 1 (PD-1), or its ligand (PD-L1) have become the mainstay for advanced malignancies. The incidence of endocrine adverse events provoked by these immune checkpoint inhibitors (ICI) is based on data from randomized controlled trials, which have their drawbacks. PubMed was searched through August 22nd, 2017, by 2 reviewers independently (J. Read More

Eur J Nucl Med Mol Imaging 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre (MUMC+), P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: We aimed to investigate the influence of both hypothyroidism and thyroid-stimulating hormone (TSH) suppression on vascular inflammation, as assessed with F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT).

Methods: Ten thyroid carcinoma patients underwent an F-FDG PET/CT during post-thyroidectomy hypothyroidism and during thyrotropin (TSH) suppression after I (radioiodine) ablation therapy. We analysed the F-FDG uptake in the carotids, aortic arch, ascending, descending, and abdominal aorta to investigate the effects of thyroid hormone status on arterial inflammation. Read More

Front Endocrinol (Lausanne) 2019 25;10:109. Epub 2019 Feb 25.

Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.

Aim of this mini review was to analyze the main variables which should be taken into account when the decision regarding a possible treatment with L-T4 has to be considered for a child with subclinical hypothyroidism (SH). The indications of periodical monitoring and vigilance have been also discussed. It was inferred that therapy should be recommended for children with underlying Hashimoto's thyroiditis and progressive deterioration of thyroid status over time, particularly in the cases with goiter and hypothyroid symptoms and in those with associated Turner syndrome or Down's syndrome and/or other autoimmune diseases. Read More

Endocr J 2019 Mar 8. Epub 2019 Mar 8.

Division of Endocrinology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya 453-8511, Japan.

Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate. It is characterized by the deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. Early disease diagnosis and advancements in intensive supportive care have reduced the mortality rate. Read More

J Pharm Pract 2019 Mar 10:897190019834771. Epub 2019 Mar 10.

1 Pharmacy Department, Indiana University Health Methodist Hospital, Indianapolis, IN, USA.

Endocrine emergencies are frequent in critically ill patients and may be the cause of admission or can be secondary to other critical illness. The ability to anticipate endocrine abnormalities such as adrenal excess or , hypothyroidism, can mitigate their duration and severity. Hyperglycemic crisis may trigger hospital and intensive care unit (ICU) admission and may be life threatening. Read More

Horm Mol Biol Clin Investig 2019 Mar 9. Epub 2019 Mar 9.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece, Phone: +30-210-7462624, Fax: +30-210-7462703.

Background Subclinical hypothyroidism (SH) is more frequent in females than males, with a female to male ratio ranging from 1.5 to 5 in the general population. The aim of this study was to evaluate for the first time the association of reproductive factors, particularly age at menarche, with SH risk. Read More

Clin Chem Lab Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Endocrinology, Diabetology and Metabolism, CHU Lille, Lille, France.

Rev Med Chil 2018 Dec;146(12):1486-1492

Servicio de Medicina, Hospital Naval A. Nef., Viña del Mar, Chile.

We report a 23 year old woman presenting with a nephrotic syndrome due to minimal change disease, central diabetes insipidus, primary hypothyroidism, vitiligo and universal alopecia. Eleven years later, she presented secondary amenorrhea due to hypogonadotropic hypogonadism, with mild hyperprolactinemia and central adrenal insufficiency. A magnetic resonance imaging of the sella turcica showed a pituitary mass with suprasellar extension that was resected using a transsphenoidal approach. Read More

Cardiovasc Drugs Ther 2019 Mar 7. Epub 2019 Mar 7.

Departamento de Cirurgia e Fisiologia, Unidade de Investigação Cardiovascular, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain high. The prevalence of heart failure with preserved ejection fraction (HFpEF) among heart failure patients remains uncertain. Read More

Eur Heart J Qual Care Clin Outcomes 2019 Mar 7. Epub 2019 Mar 7.

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Aims: Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anemia of the elderly in HF. Thus, we aimed to determine the incidence of anemia, to characterize diagnostic testing patterns for potentially reversible causes of anemia, and to evaluate the independent association between incident anemia and long-term morbidity and mortality.

Methods And Results: Within the Cardiovascular Research Network (CVRN), we identified adults age ≥65 years with diagnosed HF between 2005-2012 and no anemia at entry. Read More

Public Health Nutr 2019 Mar 8:1-9. Epub 2019 Mar 8.

Department of Endocrinology,Hospital Universitário Clementino Fraga Filho,Universidade Federal do Rio de Janeiro,Rua Prof. Rodolpho Paulo Rocco 255,9º andar,sala 9E23,Rio de Janeiro,RJ 21941-913,Brazil.

Objective: To assess iodine status and its effects on maternal thyroid function throughout pregnancy.

Design: In the present prospective cohort study, three urinary samples were requested for urinary iodine concentration (UIC) determinations in both the first and third gestational trimesters. Serum thyrotropin (TSH) and free thyroxine (FT4) were analysed in both trimesters and thyroid antibodies were assessed once. Read More

Clin Obstet Gynecol 2019 Mar 5. Epub 2019 Mar 5.

Medicine and Obstetrics and Gynecology, Division of Endocrinology, Diabetes & Metabolism, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Postpartum thyroiditis (PPT) is an autoimmune-mediated destructive thyroiditis that occurs in the first year postpartum with a prevalence of 5%. In order to appropriately counsel and treat the patient, physicians need to recognize the signs and symptoms of PPT and distinguish PPT from Graves hyperthyroidism. This review of PPT will discuss the etiology, clinical course, risk factors, prognosis, and treatment of PPT. Read More

Ecotoxicol Environ Saf 2019 Mar 4;174:224-235. Epub 2019 Mar 4.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China. Electronic address:

In recent years, decabromodiphenyl ethane (DBDPE), a new alternative flame retardant to the decabrominated diphenyl ethers (BDE-209), is widely used in a variety of products. Previous studies have indicated that DBDPE, like BDE-209, could disrupt thyroid function. However, compared with BDE-209, the degrees of thyrotoxicosis induced by DBDPE were not clear. Read More

Arq Bras Cardiol 2019 Feb 28. Epub 2019 Feb 28.

Serviço de Endocrinologia e Metabologia do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG - Brazil.

Background: The association of subclinical thyroid dysfunction (STD) with cardiac arrhythmias remains controversial, particularly in the non-elderly population.

Objective: To investigate whether STD was associated with cardiac arrhythmias in a cohort of middle-aged and older adults.

Methods: Baseline data of the Longitudinal Study of Adult Health, ELSA-Brasil (35-74 years) were collected from 2008 to 2010. Read More

Aust N Z J Psychiatry 2019 Mar 7:4867419833171. Epub 2019 Mar 7.

2 West Moreton Health Service, Ipswich, QLD, Australia.

Objective:: Hypothyroidism is a well-documented consequence of lithium treatment. Less well known is a possible association between lithium therapy and hyperthyroidism. This may have clinical implications as rapid changes in thyroid hormones may worsen a person's affective state, while symptoms of hyperthyroidism can mimic those of mania. Read More

Endocrine 2019 Mar 6. Epub 2019 Mar 6.

Department of Human Pathology Gaetano Barresi, University of Messina, Messina, Italy.

Purpose: In 236 pregnant women, we showed that selective or predominant consumption of swordfish (group A) was associated with high rates of positivity for serum thyroid autoantibodies (TPOAb and TgAb) throughout day 4 postpartum. In contrast, selective or predominant consumption of oily fish (group B) was associated with TPOAb and TgAb negativity. Rates were intermediate in group C (scanty consumption of swordfish) and group D (consumption of fish other than swordfish and oily fish). Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):222-224

Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody, which is a new drug for tumor immunotherapy. A 73-year-old female patient with colorectal cancer 3 years after surgery was treated in the Endocrinology Department of Third Xiangya Hospital, Central South University, who developed severe hypothyroidism resulting from treatment with nivolumab. After 4 months treatment of nivolumab, this patient presented with symptoms such as fatigue, dizziness, jaundice and palpebral edema, with decreased levels of FT3 and FT4 and elevated levels of TSH. Read More

Endocrinol Diabetes Metab Case Rep 2019 Mar 5;2019. Epub 2019 Mar 5.

Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland.

Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy and improved outcomes for patients with advanced disease. Pembrolizumab, a monoclonal antibody that acts as a programmed cell death 1 (PD-1(PDCD1)) inhibitor, has been approved for the treatment of advanced melanoma and other solid tumours. Immune-related adverse events (irAEs) including endocrinopathies have been well described with this and other PD-1 inhibitors. Read More

J Neurosurg 2019 Mar 1:1-11. Epub 2019 Mar 1.

2Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Houston, Texas.

OBJECTIVEAs imaging technology has improved, more unruptured intracranial aneurysms (UIAs) are detected incidentally. However, there is limited information regarding how UIAs change over time to provide stratified, patient-specific UIA follow-up management. The authors sought to enrich understanding of the natural history of UIAs and identify basic UIA growth trajectories, that is, the speed at which various UIAs increase in size. Read More

Hormones (Athens) 2019 Mar 5. Epub 2019 Mar 5.

Division of Pediatric Endocrinology, UTHealth, The University of Texas Health Science Center in Houston/McGovern Medical School, 6431 Fannin 3.122, Houston, TX, 77030, USA.

Making any medical diagnosis of an individual appearing in an old painting is risky. Throughout history, the famous painting of the Mona Lisa by Leonardo da Vinci has challenged many scientists and physicians to scrutinize this striking and enigmatic female image for the purpose of potentially explaining the woman "behind the smile" and offering a medical diagnosis of her state of health. A recent proposal was that she suffered from severe hypothyroidism and that her asymmetric smile was due to psychomotor retardation. Read More

Echocardiography 2019 Mar 4. Epub 2019 Mar 4.

Cardiology Department, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background: This study aimed to explore the impact of overt hypothyroidism on diastolic left ventricular (LV) deformation and the effect of levothyroxine therapy using 2-dimensional speckle-tracking echocardiography (STE) strain rate (SR) imaging.

Methods: Forty-seven newly diagnosed hypothyroidic patients and 51 controls were prospectively enrolled. All participants underwent comprehensive 2-dimensional echocardiography. Read More

Mayo Clin Proc 2019 Mar;94(3):544-545

Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Mayo Clin Proc 2019 Mar;94(3):544

Public Health England, London, United Kingdom.

Acta Oncol 2019 Mar 4:1-8. Epub 2019 Mar 4.

g Department of Medical Oncology , Leiden University Medical Center , Leiden , the Netherlands.

Background: There is an unmet need for markers predicting the outcome of patients with advanced soft tissue sarcoma (STS) treated with pazopanib. Since toxicity might be related to the anti-tumor activity of the drug, the aim of this study was to determine whether pazopanib-induced proteinuria, hypothyroidism and cardiotoxicity grade 3-4 were associated with outcome.

Methods: The combined results of the EORTC 62043 and 62072 trials were retrospectively assessed and used in a landmark analysis to evaluate the effect of the toxicities on progression-free survival (PFS) and overall survival (OS), using the Kaplan-Meier method and Cox regression models. Read More

Pol Merkur Lekarski 2019 Feb;46(272):80-83

Department of Dermatology, Jagiellonian University, Collegium Medicum, Cracow, Poland.

Androgenetic alopecia (AGA in men/female pattern hair loss FPHL in women) has been associated with the most frequent culprit of hair loss concerning both men and women. It may be viewed as chronic, progressive, non scarring type of hair loss. The main factor in its pathophysiological mechanism plays genetic susceptibility to androgens of certain individuals. Read More