Search Our Scientific Publications & Authors

J Pharmacokinet Pharmacodyn 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.

Modeling of retrospectively collected multi-center data of a rare disease in pediatrics is challenging because laboratory data can stem from several decades measured with different assays. Here we present a retrospective pharmacometrics (PMX) based data analysis of the rare disease congenital hypothyroidism (CH) in newborns and infants. Our overall aim is to develop a model that can be applied to optimize dosing in this pediatric patient population since suboptimal treatment of CH during the first 2 years of life is associated with a reduced intelligence quotient between 10 and 14 years. Read More

Curr Opin Pediatr 2021 Jun 9. Epub 2021 Jun 9.

Division of Pediatric Endocrinology, Advocate Children's Hospital, Oak Lawn, Illinois Division of Pediatric Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Amiodarone-induced thyroid dysfunction is well established. The present review discusses recent literature related to the effects of amiodarone on the thyroid gland and thyroid function in pediatrics.

Recent Findings: Current guidelines in adults treated with amiodarone recommend baseline thyroid function testing followed by initiation of thyroid hormone monitoring after 3 months on therapy. Read More

BMJ 2021 Jun 11;373:n1463. Epub 2021 Jun 11.

Bridgewater Surgeries, Watford, UK

Cureus 2021 May 8;13(5):e14911. Epub 2021 May 8.

Department of Endocrinology, Hamad Medical Corporation, Doha, QAT.

Normal thyroid hormone level is essential to maintain the normal physiologic function of the human body. Disturbances of these hormone levels have variable clinical manifestations ranging from asymptomatic to severe illness. Resistance to thyroid hormone (RTH) is a syndrome characterized by reduced intracellular action of T3, the active thyroid hormone. Read More

Front Endocrinol (Lausanne) 2021 25;12:653407. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Pregnancy is a complex state with many endocrinological challenges to a woman's physiology. Gestational Hypothyroidism (GHT) is an emerging condition where insufficiency of the thyroid gland has developed during pregnancy in a previously euthyroid woman. It is different to overt hypothyroidism, where marked elevation of thyroid-stimulating hormone with corresponding reduction in free thyroxine levels, is well known to cause detrimental effects to both the mother and the baby. Read More

Eur Rev Med Pharmacol Sci 2021 May;25(10):3745-3751

Department of Endocrinology, Sakarya University Medicine Faculty, Sakarya, Turkey.

Objective: Increased calprotectin (S100A8/A9) levels have been demonstrated in many acute and chronic inflammatory processes. Subacute thyroiditis is an inflammatory disease of the thyroid gland. In our study, we investigated the value of this inflammation marker in the diagnosis and follow-up of subacute thyroiditis. Read More

Front Endocrinol (Lausanne) 2021 24;12:604070. Epub 2021 May 24.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objective: To evaluate the small intestinal bacterial overgrowth (SIBO) of subclinical hypothyroidism of pregnant women, and explore their possible relevance.

Methods: In total, 224 pregnant women with subclinical hypothyroidism during pregnancy (study group) and 196 pregnant women whose thyroid function was normal (control group) were enrolled in this study. Lactulose-based hydrogen and methane breath test was performed to evaluate the growth of intestinal bacteria. Read More

Radiol Bras 2021 May-Jun;54(3):VII

Director of the Ultrasound Department at the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Professor in the Graduate Program in Radiology and Oncology at the FMUSP, and Coordinator of Ultrasound Services for the DASA Group, São Paulo, SP, Brazil; President-Elect of the World Federation for Ultrasound in Medicine and Biology (2019-2021). Email:

BMJ 2021 06 9;373:n1458. Epub 2021 Jun 9.

Clinical Biochemistry, New Cross Hospital, Black Country Pathology Services, Royal Wolverhampton NHS Trust, Wolverhampton, UK.

Ann Palliat Med 2021 May;10(5):5400-5406

Department of Pharmacy, Shenzhen Hospital of Southern Medical University, Shenzhen, China.

Background: To study the various factors affecting the anticoagulant effect of warfarin, and to promote the rational use of warfarin.

Methods: We collected the medical records of 125 hospitalized patients who used warfarin from January 2018 to December 2019. Statistical analysis was performed on characteristics such as gender, age, treatment, diabetes, hyperlipidemia, hyperthyroidism, hypothyroidism, hepatitis, renal insufficiency, and nephritis; along with other pathological factors, such as aspirin, clopidogrel, spironolactone, amiodarone, amlodipine, trimetazidine, bisoprolol, isosorbide, atorvastatin, furosemide, digoxin, metoprolol, acarbose, levamlodipine, enoxaparin, moxifloxacin, levofloxacin, other drug interactions, and comorbidities. Read More

Clin Lab 2021 Jun;67(6)

Background: Vitamin D acts as immunomodulatory molecule and its deficiency has been implicated in various autoimmune diseases including immune mediated hypothyroidism. However, its association with thyroid hormones is ambiguous. The present study was therefore aimed to explore the relationship of vitamin D with thyroid hormone levels in a population enrolled for health care check up in a tertiary care hospital. Read More

Int J Clin Pract 2021 Jun 9:e14484. Epub 2021 Jun 9.

H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342, Kraków, Poland.

Objective: Autoimmune thyroid diseases, including Hashimoto's thyroiditis, are the most common ones among autoimmune diseases. The reported effects of selenium supplementation on the course of Hashimoto's thyroiditis are not consistent. It is therefore important to continue this line of research. Read More

Medicine (Baltimore) 2021 May;100(19):e25843

Department of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan.

Abstract: Pituitary stalk interruption syndrome (PSIS) is a rare disease associated with either isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD). In older children and adults, most patients experience short stature or hypogonadism. Neonatal PSIS is extremely rare and is difficult to recognize due to absence of dwarfism. Read More

Exp Brain Res 2021 Jun 9. Epub 2021 Jun 9.

Dalian Medical University, Dalian, 116044, China.

Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. Read More

JAMA Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: Although granuloma annulare (GA) has been associated with several other conditions, these studies have been limited by single-center designs and small sample sizes.

Objective: To evaluate whether there is an association between GA and type 2 diabetes, hyperlipidemia, autoimmune conditions, and hematologic malignant neoplasms, using a large population-based cohort study.

Design, Setting, And Participants: This retrospective cohort study conducted between January 1, 2016, and June 30, 2019, used deidentified data from the US Optum Clinformatics Data Mart Database. Read More

Andes Pediatr 2021 Feb 22;92(1):59-66. Epub 2021 Feb 22.

Departamento de Endocrinología Pediátrica, Hospital de Pediatría, Ciudad de México, México.

Introduction: Hypothyroidism has been associated with dyslipidemia. Its treatment with levothyroxine has shown a positive effect on the lipid profile in adults, however, there is a lack of data on the pediatric popu lation.

Objective: to evaluate the effect of the thyroid profile normalization on the lipid profile in children with primary hypothyroidism. Read More

Andes Pediatr 2021 Apr;92(2):235-240

Instituto Nacional de Salud del Niño, Lima, Peru.

Introduction: Congenital hypothyroidism (CH) is the most common cause of preventable intellectual disability in the pediatric population. Early diagnosis and treatment during the first month of life are essential to avoid delaying the neuropsychological development of these patients.

Objective: to describe the social, cognitive, and psychomotor development of children with CH treated at the National Institute of Child Health (INSN) in Lima, Peru. Read More

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Cracow, Poland.

Objectives: The aim of the study was to evaluate whether the presence of the disease in pregnancy influences the effectiveness and safety of delivery preinduction with prostaglandins: misoprostol vaginal insert and dinoprostone vaginal gel.

Material And Methods: This is aretrospective cohort study conducted of 560 pregnant women. The concomitant diseases mainly recorded were diabetes mellitus, hypertensive diseases, intrahepatic cholestasis of pregnancy, asthma, thrombocytopenia, and hypothyroidism. Read More

J Clin Endocrinol Metab 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Context: Children with congenital hypothyroidism (CH) are at risk for suboptimal neurodevelopment.

Objectives: To evaluate neurocognitive function and white matter microstructure in children with permanent or transient CH and to correlate these findings with disease severity.

Design, Participants And Methods: A retrospective and prospective observational study was conducted in 39 children with permanent or transient CH, and in 39 healthy children. Read More

J Endocr Soc 2021 Jul 15;5(7):bvab041. Epub 2021 Mar 15.

Section of General Internal Medicine, University of Chicago, Chicago, IL 60637, USA.

Purpose: Both undertreatment and overtreatment of hypothyroidism with thyroid hormone are associated with adverse clinical outcomes. Disparities in the treatment of hypothyroidism may lead to a higher risk of adverse outcomes for certain sociodemographic groups. Our objectives were to identify sociodemographic disparities between those with treated and untreated hypothyroidism, and between those who were adequately and inadequately treated. Read More

Cureus 2021 May 5;13(5):e14858. Epub 2021 May 5.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver diseases globally. Because thyroid hormones play a crucial role in lipid metabolism, thyroid dysfunction has been implicated in NAFLD pathogenesis in the past decade, with hypothyroidism-induced NAFLD being regarded as a distinct disease entity. However, there has been no common consensus yet, and several studies have found contradictory results. Read More

Case Rep Endocrinol 2021 19;2021:5525156. Epub 2021 May 19.

Department of Neurology, Sutherland Hospital, Sydney, NSW, Australia.

Autoimmune hypothyroidism may result in a wide range of neuromuscular disorders. The frequently observed neurological manifestations of acquired hypothyroidism include mild to moderate myopathy and sensorimotor neuropathy, which usually resolve by clinical and electrophysiological criteria, in adults treated with thyroid hormone replacement. We report a case of a 30-year-old male with severe hypothyroidism secondary to chronic autoimmune thyroiditis who presented with a 2-year history of progressive fatigue, upper and lower limb weakness, myalgia, and intermittent paraesthesia. Read More

Ther Adv Endocrinol Metab 2021 24;12:20420188211001165. Epub 2021 Apr 24.

Pediatric Endocrinology, Cliniques universitaires Saint Luc, Av. Hippocrate 10, Brussels, B-1200, Belgium.

Background: Amiodarone treatment is effective against various types of arrhythmias but is associated with adverse effects affecting, among other organs, thyroid function. Amiodarone-induced thyroid dysfunction was not thoroughly evaluated in children as it was in adults, yet this affection may lead to irreversible neurodevelopmental complications. Our study aimed to define the incidence and risk factors of amiodarone-induced thyroid dysfunction in children. Read More

J Med Life 2021 Mar-Apr;14(2):243-249

Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

The thyroid hormone plays a vital role in the development and maturation of the nervous system not only during prenatal and perinatal age but also in adults. "Peripheral marker hypothesis" revealed that gene expression changes in some regions of the brain are reflected into the peripheral blood lymphocytes. The objective of the study was to investigate changes in the gene expression profile of neuropeptides and their receptors in patients with different forms of thyroid pathology. Read More

Pediatric Health Med Ther 2021 1;12:269-278. Epub 2021 Jun 1.

School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Background: Knowledge of the normal variation in AF size may be helpful to cue early diagnosis of congenital hypothyroidism, hyperthyroidism, cardiac disease, meningitis, degree of dehydration or provide a clue to disorders of neural and skeletal development. However, the data is scarce. Therefore, this study was aimed to determine AF size and associated factors among term neonates on the first day of life born in Jimma University Medical Center (JUMC), Southwest Ethiopia. Read More

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):206-211. Epub 2020 Apr 13.

Hospital Militar Central, Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Buenos Aires, Argentina.

Background: There are well-recognized relationships between thyroid hormones, heart and peripheral vascular system. Thyroid hormones have relevant actions on the heart and circulation, generate multiple effects including hemodynamic changes and exert mediated effects on cardiac cells through gene expression.

Clinical Case: We present a 64-year-old woman with diagnosis of dilated cardiomyopathy with reduced ejection fraction, in whom coronary disease was thought of as the most probable etiology by clinical antecedents but in the evolution, other possible etiologies were to appear. Read More

Ann Acad Med Singap 2021 05;50(5):402-410

Department of Endocrinology, National University Health System, Singapore.

Introduction: Childhood radiation exposure is a known risk factor for thyroid malignancy and dysfunction. However, local data are limited and there is no consensus on the modality and frequency of screening in this high-risk group.

Methods: Retrospective analysis study evaluating patients with childhood radiation exposure in 2006-2016 and minimum of 1-year follow-up. Read More

Nat Commun 2021 06 7;12(1):3355. Epub 2021 Jun 7.

F. Hoffmann-La Roche, Basel, Switzerland.

Activation of systemic immune responses using PD-1 checkpoint inhibitors is an essential approach to cancer therapy. Yet, the extent of benefit relative to risk of immune related adverse events (irAE) varies widely among patients. Here, we study endocrine irAE from 7 clinical trials across 6 cancers where atezolizumab (anti-PD-L1) was combined with chemotherapies and compared to standard of care. Read More

Indian J Tuberc 2021 Jul 4;68(3):379-383. Epub 2021 Jan 4.

Joint Director of Tuberculosis, Hyderabad, Telangana, India.

Background: Treatment outcomes for Multidrug-Resistant Tuberculosis (MDR TB) is generally poor. The study aims to know about the treatment outcomes of MDR-TB under programmatic conditions in Hyderabad District and to analyze the factors influencing the treatment outcomes.

Methods: This is a retrospective study in which 377 patients of Hyderabad district, Telangana state who were diagnosed with MDR TB and registered at Drug Resistance TB Treatment site of Government General & Chest Hospital, Hyderabad from 4th quarter 2008 to 4th quarter 2013 were included in the study. Read More

Eur Arch Otorhinolaryngol 2021 Jun 7. Epub 2021 Jun 7.

Health Sciences University Haydarpaşa Numune Health Practice and Research Center, İstanbul, Turkey.

Objectives: In this study, we aimed to investigate the laryngeal and parotid histopathological alterations in rats with experimentally induced postnatal hypothyroidism.

Materials And Methods: 200-300 g weighed Wistar albino rats were included in this study. The rats were randomly divided into four groups: group 1 is control and the other groups are experimental groups. Read More