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    Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?
    Acta Dermatovenerol Croat 2018 Apr;26(1):61-63
    Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;
    Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

    Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly.
    J Vet Intern Med 2018 May 21. Epub 2018 May 21.
    Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado.
    Background: Conventional fractionated radiotherapy has been shown to be partially effective for management of pituitary tumors in cats that cause acromegaly and diabetes mellitus (DM), but, the efficacy and safety of stereotactic radiation therapy (SRT) as a treatment for acromegalic cats has not been described.

    Hypothesis: Stereotactic radiation therapy is an effective and safe treatment for controlling acromegaly associated with pituitary adenomas in cats. Additionally, SRT-treated acromegalic cats with DM will experience a decrease in insulin requirements after radiation therapy. Read More

    Management of inadvertent needle penetration resulting in subretinal triamcinolone acetonide and retinal detachment.
    Am J Ophthalmol Case Rep 2018 Jun 19;10:288-289. Epub 2018 Apr 19.
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, United States.
    Purpose: To report management of inadvertent needle penetration during subtenons triamcinolone acetonide administration resulting in retinal detachment.

    Observations: A 71-year-old female with history of diabetes, hypothyroidism, and mild myopia underwent subtenons triamcinolone acetonide (TA) injection in the right eye for nodular scleritis. There was unexpected patient movement concurrent with the injection resulting in needle penetration, subretinal and intravitreal injection of TA, superotemporal retinal break, and macula-involving retinal detachment. Read More

    Genetically modified mouse models to investigate thyroid development, function and growth.
    Best Pract Res Clin Endocrinol Metab 2018 Jun 3;32(3):241-256. Epub 2018 Apr 3.
    Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, Turku Center for Disease Modeling, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland; Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20521, Turku, Finland. Electronic address:
    The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways. TSH primarily activates the G-pathway, and at higher concentrations also the G-pathway, leading to an increase of intracellular cAMP and Ca, respectively. Read More

    Association Between Thyroid Dysfunction and Lipid Profiles Differs According to Age and Gender: Results from the Korean National Health and Nutrition Examination Survey.
    Thyroid 2018 May 19. Epub 2018 May 19.
    Asan Medical Center, Internal Medicine , 88, Olympic-ro-43-gil, Songpa-gu , Seoul, Korea, Republic of , 05505 ;
    Background Lipid profiles of men and women change differently during the aging process. Guidelines recommend that dyslipidemia patients should consider screening for hypothyroidism without consideration of age or gender. Methods Data from the sixth Korean National Health and Nutrition Examination were used. Read More

    GLIS1-3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases.
    Cell Mol Life Sci 2018 May 19. Epub 2018 May 19.
    Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
    Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. Read More

    Is Parenteral Levothyroxine Therapy Safe in Intractable Hypothyroidism?
    J Natl Med Assoc 2018 Jun 21;110(3):245-249. Epub 2017 Jun 21.
    Uludag University, Department of Endocrinology and Metabolic Disorders, Turkey.
    Case: A 32-year old woman was admitted to the hospital due to intractable hypothyroidism refractory to high dose of oral l-thyroxine therapy. She underwent total thyroidectomy and radioactive iodine therapy due to papillary thyroid cancer. After excluding poor adherence to therapy and malabsorption, levothyroxine absorption test was performed. Read More

    Massive pericardial effusion without cardiac tamponade due to subclinical hypothyroidism (Hashimoto's disease).
    Rural Remote Health 2018 May 20;18(2):4384. Epub 2018 May 20.
    Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece
    Context: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Read More

    Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs.
    Domest Anim Endocrinol 2018 Apr 24;65:1-8. Epub 2018 Apr 24.
    Laboratory of Comparative Medical Genetics and Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
    An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. Read More

    Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis.
    J Endocrinol Invest 2018 May 18. Epub 2018 May 18.
    Department of Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
    Purpose: Irisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects. Read More

    Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism.
    Indian J Pediatr 2018 May 19. Epub 2018 May 19.
    Department of Pediatrics, Jaslok Hospital and Research Centre, Mumbai, India.
    Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. Read More

    Prevalence of temporomandibular disorders in patients with Hashimoto thyroiditis.
    J Orofac Orthop 2018 May 17. Epub 2018 May 17.
    Department of Orthodontics and Orofacial Orthopedics, University of Erlangen Medical School, Erlangen, Germany.
    Objectives: Autoimmune thyroid disease (AITD), also known as Hashimoto thyroiditis (HT), is a degenerative inflammatory disease with high prevalence among women and has been associated with fibromyalgia and widespread chronic pain. The goal was to determine the frequency of temporomandibular disorders (TMD) in patients with HT.

    Methods: In all, 119 women (age 19-60 years) were divided into a study (52 women diagnosed with HT) and a control (67 healthy individuals, of which 15 were excluded) group. Read More

    Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients.
    BMC Cancer 2018 May 18;18(1):575. Epub 2018 May 18.
    Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515000, Guangdong, China.
    Background: The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy.

    Methods: Medical notes of 174 NPC patients after radiotherapy were reviewed. Biochemical hypothyroidism was defined as an elevated level of serum thyroid-stimulating hormone (TSH) value with a normal or decreased level of serum free thyroxine (fT4) after radiotherapy. Read More

    NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India.
    J Cosmet Dermatol 2018 May 17. Epub 2018 May 17.
    Department of Dermatology, Venereology and Leprology, Government Medical College and Hospital, Chandigarh, India.
    Background: Diffuse hair loss (DHL) is a common problem in adult women and has a major impact on quality of life. Ascertaining the etiological diagnosis is a challenging task in such patients. Satisfactory treatment can only be instituted after ascertaining the cause of hair loss. Read More

    [Thyroid and pregnancy].
    Internist (Berl) 2018 May 17. Epub 2018 May 17.
    Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland.
    During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. Read More

    DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components.
    Sci Rep 2018 May 17;8(1):7794. Epub 2018 May 17.
    Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Napoli, Italy.
    DNAJC17 is a heat shock protein (HSP40) family member, identified in mouse as susceptibility gene for congenital hypothyroidism. DNAJC17 knockout mouse embryos die prior to implantation. In humans, germline homozygous mutations in DNAJC17 have been found in syndromic retinal dystrophy patients, while heterozygous mutations represent candidate pathogenic events for myeloproliferative disorders. Read More

    Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism.
    J Trace Elem Med Biol 2018 Jul 23;48:134-140. Epub 2018 Mar 23.
    University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia.
    Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr, Zn, As, Cd in collision mode, and Mn, Co, Ni, Cu, Se in standard mode. Read More

    Homology of pendrin, sodium-iodide symporter and apical iodide transporter.
    Front Biosci (Landmark Ed) 2018 Jun 1;23:1864-1873. Epub 2018 Jun 1.
    Department of Clinical and Experimental Medicine, Dermatology, University of Messina, via Consolare Valeria, Gazzi, 98125 Messina, Italy,
    We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins. They shared 63 identical and 66 similar residues (overall homology 14. Read More

    Thyroid Stimulating Hormone Receptor Antibodies in Thyroid Eye Disease-Methodology and Clinical Applications.
    Ophthalmic Plast Reconstr Surg 2018 May 2. Epub 2018 May 2.
    Department of Medicine I, Molecular Thyroid Research Laboratory, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
    Background: Thyroid stimulating hormone receptor antibodies (TSHR-Ab) cause autoimmune hyperthyroidism and are prevalent in patients with related thyroid eye disease (TED).

    Purpose: To provide a historical perspective on TSHR-Ab and to present evidence-based recommendations for clinical contemporary use.

    Methods: The authors review the recent literature pertaining to TSHR-Ab in patients with TED and describe the various immunoassays currently used for detecting TSHR-Ab and their clinical applications. Read More

    Diabetes-Related Distress Assessment among Type 2 Diabetes Patients.
    J Diabetes Res 2018 26;2018:7328128. Epub 2018 Mar 26.
    Taif University School of Medicine, Taif, Saudi Arabia.
    Background And Objectives: Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes Distress Scale-17 items (DDS-17) and its relation to complications and treatment modalities. Read More

    Preoperative thyroid function and weight loss after bariatric surgery.
    Int J Obes (Lond) 2018 May 16. Epub 2018 May 16.
    Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal.
    Thyroid function has an important role on body weight regulation. However, the impact of thyroid function on weight loss after bariatric surgery is still largely unknown. We evaluated the association between preoperative thyroid function and the excess weight loss 1 year after surgery, in 641 patients with morbid obesity who underwent bariatric surgery. Read More

    Thyroid Status in Children with Transfusion Dependent Hb-E β-Thalassaemia.
    Mymensingh Med J 2018 Apr;27(2):348-357
    Dr Tania Sharmin, Resident Medical Officer, Department of Paediatric Nephrology, Dhaka Shishu Hospital, Dhaka, Bangladesh; E-mail:
    Despite improved haematological care, multi-endocrine dysfunction is a common complication in thalassemia. Iron overload is thought to be the most likely mechanism in thyroid dysfunction in these patients. Moreover, chronic tissue hypoxia might havedirect toxic effect on thyroid gland resulting in hypothyroidism. Read More

    Prevalence of subclinical hypothyroidism in obese children or adolescents and association between thyroid hormone and the components of metabolic syndrome.
    J Paediatr Child Health 2018 May 16. Epub 2018 May 16.
    Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
    Aim: Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones.

    Methods: A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI. Read More

    Effects of Iodized Salt and Iodine Supplements on Prenatal and Postnatal Growth: A Systematic Review.
    Adv Nutr 2018 May;9(3):219-237
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.
    Hypothyroidism due to iodine deficiency can impair physical development, most visibly in the marked stunting of myxedematous cretinism caused by severe in utero iodine deficiency. Whether iodine repletion improves growth in noncretinous children is uncertain. Therefore, the aim of our systematic review was to assess the effects of iodine fortification or supplementation on prenatal and postnatal growth outcomes in noncretinous children. Read More

    Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015).
    Endocrinol Metab (Seoul) 2018 May 4. Epub 2018 May 4.
    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    No nationwide data have been published about thyroid hormone levels and urinary iodine concentrations (UICs) in Korea. The Korea Centers for Disease Control and Prevention and the Korean Thyroid Association established a project to evaluate the nationwide thyroid hormone profile and UICs in healthy Koreans as part of the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013 to 2015), a nationwide, cross-sectional survey of the Korean population that enrolled 7,061 individuals who were weighted to represent the entire Korean population. Based on the KNHANES VI, the geometric mean value of serum thyroid stimulating hormone was 2. Read More

    Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism.
    Arch Med Sci 2018 Apr 23;14(3):521-526. Epub 2016 Mar 23.
    Department of Endocrinology, Faculty of Medicine, Hitit University, Corum, Turkey.
    Introduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. Read More

    [Advances in postoperative thyroid-stimulating hormone suppression therapy in females with thyroid cancer].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;53(5):397-400
    Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200030, China.
    Differentiated thyroid cancer is the most common malignant carcinoma in female population.Postoperative long-term thyroid-stimulating hormone(TSH) suppression therapy can reduce the risk of recurrence for differentiated thyroid cancer and control the progress of the disease, but it also induces simultaneously subclinical hypothyroidism and imposes negative effect on female. In addition to cardiovascular disease, TSH suppression therapy can lead to the alteration of sex hormone metabolism, menstrual disorder, poor influence on pregnancy and osteoporosis. Read More

    Hypothyroidism after Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.
    Radiat Res 2018 May 15. Epub 2018 May 15.
    b   Biostatics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland.
    While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a risk analysis study of hypothyroidism with radiation dose to the thyroid gland and the hypothalamic-pituitary axis among survivors of childhood cancer. Utilizing data from the Childhood Cancer Survivor Study, a cohort of 14,364 five-year survivors of childhood cancer diagnosed at 26 hospitals in the U. Read More

    Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats.
    Neuroreport 2018 May 14. Epub 2018 May 14.
    EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed the characteristics of ephrin-A5 expression in the hippocampus of CH rats. Read More

    Evaluation of thyroid gland as an organ at risk after breast cancer radiotherapy: a systematic review and meta-analysis.
    Clin Transl Oncol 2018 May 14. Epub 2018 May 14.
    Department of Radiotherapy and Medical Physics, Faculty of Para medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran.
    Background: Radiotherapy can often lead to thyroid dysfunction. Some studies demonstrated that treatment of breast cancer by RT can expose thyroid gland to high doses of radiation. The aim of this systematic review is to evaluate consideration of thyroid gland as an organ at risk. Read More

    Spinal Muscular Atrophy With Respiratory Distress Type 1-A Child With Atypical Presentation.
    Child Neurol Open 2018 19;5:2329048X18769811. Epub 2018 Apr 19.
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR.
    The authors report a child with spinal muscular atrophy with respiratory distress type 1 (SMARD1). She presented atypically with hypothyroidism and heart failure due to septal defects that required early heart surgery and microcephaly in association with cerebral atrophy and thin corpus collosum. The subsequent asymmetrical onset of diaphragmatic paralysis, persistent hypotonia, and generalized muscle weakness led to the suspicion of spinal muscular atrophy with respiratory distress type 1. Read More

    A Novel Missense Mutation in SLC5A5 Gene in a Sudanese Family with Congenital Hypothyroidism.
    Thyroid 2018 May 15. Epub 2018 May 15.
    University of Miami School of Medicine, 12235, Medicine , 1120 NW 14th St , Suite 310F , Miami, Florida, United States , 33136-1015 ;
    Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). Read More

    A Pivotal Field Study to Support the Registration of Levothyroxine Sodium Tablets for Canine Hypothyroidism.
    J Am Anim Hosp Assoc 2018 May 14. Epub 2018 May 14.
    From LLOYD, Inc., Shenandoah, Iowa (C.M.K.M., W.E.L.); and AlcheraBio LLC, Edison, New Jersey (V.A.L., J.A.J.).
    A prospective, pivotal, multicenter field study to evaluate the dose regimen, effectiveness, and safety of levothyroxine sodium tablets, USP for the treatment of hypothyroidism and hypothyroidism-associated clinical signs in dogs was conducted. Ninety-two dogs diagnosed with primary hypothyroidism met the entrance criteria and were enrolled into the study. Levothyroxine sodium was administered to each dog on a daily basis either as the whole dose q 24 hr or as half the dose q 12 hr. Read More

    Massive pleural and pericardial effusion due to hypothyroidism in a patient with a surgically treated thyroid-stimulating hormone-producing pituitary adenoma.
    Acta Clin Belg 2018 May 14:1-4. Epub 2018 May 14.
    a Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine , KyungHee University Hospital , Seoul , Korea.
    Hypothyroidism is relatively rare etiology of serositis with effusion, but massive pleural effusion is very unusual. This is a report of massive pleural effusion in patient taking methimazole after surgical resection of thyroid-stimulating hormone (TSH)-producing pituitary adenoma (TSHoma). The patient was clinically and biochemically hypothyroid and responded well to discontinuation of methimazole and thyroid hormone replacement therapy. Read More

    Growth and Endocrine Function in Tunisian Thalassemia Major Patients.
    Mediterr J Hematol Infect Dis 2018 1;10(1):e2018031. Epub 2018 May 1.
    Pediatric Immuno-Hematology Unit, Bone Marrow Transplantation Center Tunis, Tunis, Tunisia.
    β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. Read More

    Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.
    Front Neuroanat 2018 27;12:31. Epub 2018 Apr 27.
    Departamento de Histología y Anatomía, Facultad de Medicina, Universidad Miguel Hernández, Sant Joan d'Alacant, Alicante, Spain.
    Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections. Read More

    Nitric oxide is involved in the hypothyroidism with significant morphology changes in female Wistar rats induced by chronic exposure to high water iodine from potassium iodate.
    Chemosphere 2018 May 3;206:320-329. Epub 2018 May 3.
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China. Electronic address:
    Epidemiological studies indicated that chronic exposure to high water iodine is associated with primary hypothyroidism (PH) and subclinical hypothyroidism (SCH). However, the mechanism is not well understood. In this study, we explored whether chronic exposure to high water iodine from potassium iodate (KIO) can induce hypothyroidism in addition to determining if nitric oxide (NO) is involved in the pathogenesis. Read More

    A retrospective study of dermatitis herpetiformis from an immunobullous disease clinic in north India.
    Int J Dermatol 2018 May 11. Epub 2018 May 11.
    Department of Histopathology, PGIMER, Chandigarh, India.
    Background: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases.

    Methods: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. Read More

    Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population.
    Int J Environ Res Public Health 2018 May 3;15(5). Epub 2018 May 3.
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan.
    Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. Read More

    Current status of the congenital hypothyroidism neonatal screening program in Adana Province, Turkey.
    J Pediatr Endocrinol Metab 2018 May 11. Epub 2018 May 11.
    Department of Pediatrics, Division of Metabolism, Cukurova University Medical Faculty, Adana, Turkey.
    Background: Congenital hypothyroidism (CH) is a common cause of mental retardation; it has a worldwide incidence ranging from 1:3000 to 1:4500 live births. Predictably, an increase in the reported incidence of primary CH occurs when the cut-off levels of thyroid-stimulating hormone are lowered. We aimed to evaluate the results of a congenital hypothyroidism screening program and current status in this study. Read More

    The etiologies and incidences of congenital hypothyroidism before and after neonatal TSH screening program implementation: a study in southern Thailand.
    J Pediatr Endocrinol Metab 2018 May 11. Epub 2018 May 11.
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
    Background: Congenital hypothyroidism (CH) is one of the common causes of intellectual disability which can be prevented by early detection of an elevated thyroid stimulating hormone (TSH) level in the newborn and by treatment with thyroxine. In Thailand, neonatal TSH screening was implemented nationwide in 2005. The objective of the study was to determine the etiologies and the estimated incidences of CH in southern Thailand before and after the implementation of a neonatal TSH screening program in 2005. Read More

    Validation of previously reported predictors for radiation-induced hypothyroidism in nasopharyngeal cancer patients treated with intensity-modulated radiation therapy, a post hoc analysis from a Phase III randomized trial.
    J Radiat Res 2018 May 10. Epub 2018 May 10.
    Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
    This study aimed to validate previously reported dosimetric parameters, including thyroid volume, mean dose, and percentage thyroid volume, receiving at least 40, 45 and 50 Gy (V40, V45 and V50), absolute thyroid volume spared (VS) from 45, 50 and 60 Gy (VS45, VS50 and VS60), and clinical factors affecting the development of radiation-induced hypothyroidism (RHT). A post hoc analysis was performed in 178 euthyroid nasopharyngeal cancer (NPC) patients from a Phase III study comparing sequential versus simultaneous-integrated boost intensity-modulated radiation therapy. RHT was determined by increased thyroid-stimulating hormone (TSH) with or without reduced free thyroxin, regardless of symptoms. Read More

    Underlying mechanism of the contractile dysfunction in atrophied ventricular myocytes from a murine model of hypothyroidism.
    Cell Calcium 2018 Feb 5;72:26-38. Epub 2018 Feb 5.
    Tecnologico de Monterrey, Escuela de Medicina, Av. Morones Prieto No. 3000 Pte., Monterrey, N.L., 64710, Mexico. Electronic address:
    Hypothyroidism (Hypo) is a risk factor for cardiovascular diseases, including heart failure. Hypo rapidly induces Ca mishandling and contractile dysfunction (CD), as well as atrophy and ventricular myocytes (VM) remodeling. Hypo decreases SERCA-to-phospholamban ratio (SERCA/PLB), and thereby contributes to CD. Read More

    Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism: Does subclinical hypothyroidism increase the risk of diabetes and cardio vascular disease together?
    Diabetes Metab Syndr 2018 May 5. Epub 2018 May 5.
    Department of Endocrinology, Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
    Background: Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue.

    Methods And Materials: Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group. Read More

    [Impact of thyroid diseases on bone].
    Internist (Berl) 2018 May 9. Epub 2018 May 9.
    MVZ Endokrinologikum Göttingen, Von-Siebold-Str. 3, 37075, Göttingen, Deutschland.
    Thyroid hormones are key regulators of skeletal development in childhood and bone homeostasis in adulthood, and thyroid diseases have been associated with increased osteoporotic fractures. Hypothyroidism in children leads to an impaired skeletal maturation and mineralization, but an adequate and timely substitution with thyroid hormones stimulates bone growth. Conversely, hyperthyroidism at a young age accelerates skeletal development, but may also cause short stature because of a premature fusion of the growth plates. Read More

    Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage.
    Oxid Med Cell Longev 2018 20;2018:2089404. Epub 2018 Mar 20.
    Instituto Politécnico Nacional, Laboratorio de Metabolismo I, Departamento de Fisiología "Dr. Mauricio Russek Berman", Escuela Nacional de Ciencias Biológicas, Av. Wilfrido Massieu s/n, Esq. Manuel L. Stampa, Unidad Profesional Adolfo López Mateos, Del. Gustavo A. Madero, 07738 Ciudad de México, Mexico.
    Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage. Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron. This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE) in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events. Read More

    A robust response to combination immune checkpoint inhibitor therapy in HPV-related small cell cancer: a case report.
    J Immunother Cancer 2018 May 9;6(1):33. Epub 2018 May 9.
    Department of Oncology, Johns Hopkins University School of Medicine, 1550 Orleans St, CRB2 5m44, Baltimore, MD, 21287, USA.
    Background: Human papillomavirus-related small cell carcinoma of the head and neck is an extremely rare, aggressive subtype with poor outcomes. Therapeutic options are limited and are largely adopted from small cell lung cancer treatment paradigms.

    Case Presentation: This report describes a 69-year old male who was diagnosed of HPV-related oropharyngeal cancer with mixed small cell and squamous cell pathology which was clinically aggressive and progressed through multimodal platinum-based therapies. Read More

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