44,739 results match your criteria Hypothyroid Myopathy


The Association of Various Metabolic Parameters with Multiple Skin Tags.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):40-43. Epub 2018 Oct 1.

Drs. Platsidaki, Vasalou, Gerodimou, Markantoni, Kouris, Gregoriou, Rigopoulos, and Kontochristopoulos are with the Department of Dermatology and Venereology at Andreas Sygros Skin Hospital in Athens, Greece.

Skin tags (STs) are benign skin lesions. Their definite etiology remains unknown. We aim to examine the association of obesity, diabetes mellitus, hyperlipidemia, thyroid abnormalities, acanthosis nigricans, and multiple STs in a Greek primary population. Read More

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October 2018
2 Reads

Chromosomal microarray and whole exome sequencing identify genetic causes of congenital hypothyroidism with extra-thyroidal congenital malformations.

Clin Chim Acta 2018 Nov 30. Epub 2018 Nov 30.

Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, People's Republic of China. Electronic address:

Background: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder. Although most patients present with isolated CH, some patients present with CH and extra-thyroidal congenital malformations (ECMs), for which less is known about the underlying genetics. The aim of this study was to investigate the genetic mechanisms in patients with CH and ECMs using chromosomal microarray (CMA) and whole exome sequencing (WES). Read More

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November 2018

Thyroid state affects HO removal by rat heart mitochondria.

Arch Biochem Biophys 2018 Nov 30. Epub 2018 Nov 30.

Dipartimento di Biologia, Università di Napoli Federico II, I-80126, Napoli, Italy.

We investigated the effects of thyroid state on the mechanisms underlying rat heart mitochondrial capacity to remove HO produced by an exogenous source. The removal rates were higher in the presence of respiratory substrates independently from thyroid state and were higher in hyperthyroid than in hypothyroid preparations. The thyroid state linked changes in HO removal rates mirrored those in HO release rates showing that endogenous and exogenous HO do not compete for the removing system. Read More

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November 2018

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.

Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.

Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More

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December 2018
2 Reads

Cognitive function in hypothyroidism: what is that deiodinase again?

Authors:
Arturo Hernandez

J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.

Treatment of hypothyroidism involves the endogenous conversion of thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and may not be optimal in some cases when based on T4 alone. In the current issue of the JCI, Jo et al. present results that explain the reduced enzymatic activity of a common genetic variant of the enzyme responsible for this conversion, type 2 deiodinase (DIO2). Read More

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December 2018

Hypothyroidism Presenting as Cardiac Emergency.

J Paediatr Child Health 2018 Dec;54(12):1404-1405

Department of Endocrinology, S.C.B Medical College, Cuttack, India.

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December 2018

Myo-inositol in autoimmune thyroiditis, and hypothyroidism.

Rev Endocr Metab Disord 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Via Savi, 10, I-56126, Pisa, Italy.

Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Read More

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December 2018

Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.

Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More

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November 2018

Efficacy of radioactive iodine treatment of graves' hyperthyroidism using a single calculated I dose.

Clin Diabetes Endocrinol 2018 28;4:20. Epub 2018 Nov 28.

1Nuclear Medicine/Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5028 USA.

Objective: To evaluate the success rate of therapeutic administration of a single calculated I activity for eliminating hyperthyroidism due to Graves' disease.

Methods And Materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated I activity of 0.2 mCi per estimated gram of thyroid tissue, adjusted for the 24-h RAIU. Read More

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November 2018

Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):88-96

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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November 2018

Treatment approach for the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a European hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):83-87

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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November 2018

Trends, Determinants and Associations of Treated Hypothyroidism in the United Kingdom, 2005 - 2014.

Thyroid 2018 Dec 1. Epub 2018 Dec 1.

School of Medicine, Cardiff University, IMEM , CEDS , C2 Link corridor , UHW , Cardiff, United Kingdom of Great Britain and Northern Ireland , CF14 4XN.

Background: Recent reports suggest that prescriptions for thyroid hormones have increased. We therefore analysed recent trends in and determinants of prevalence of treated hypothyroidism across the United Kingdom (UK).

Methods: UK-wide data held by the National Health Service and the Office of National Statistics were examined. Read More

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December 2018

The Effect of Age on Fracture Healing Time in Metacarpal Fractures.

Hand (N Y) 2018 Dec 2:1558944718813730. Epub 2018 Dec 2.

1 New York University, New York City, USA.

Background: Older patients are treated for fracture with increasing frequency. Although studies on animals suggest that older mice and rats heal fractures more slowly, the clinical implications remain unclear. A better understanding of differences in healing with age can help customize fracture treatment. Read More

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December 2018

Long-term Outcome in Heart Failure Patients Treated with Levothyroxine: An Observational Nationwide Cohort Study.

J Clin Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

Department of Endocrinology, Herlev-Gentofte University Hospital, Herlev, Denmark.

Context: Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF).

Objective: Examining the effects of L-T4 in patients with HF.

Design: Retrospective cohort study. Read More

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December 2018

Hypoceruloplasminemia: an unusual biochemical finding in a girl with Hashimoto's thyroiditis and severe hypothyroidism.

Pediatr Med Chir 2018 Dec 5;40(2). Epub 2018 Dec 5.

Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina.

Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs. Read More

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December 2018

Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.

Ecotoxicol Environ Saf 2018 Nov 30;170:25-32. Epub 2018 Nov 30.

School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Organophosphate flame retardants (OPFRs) have been widely used as alternatives to polybrominated diphenyl ethers for fire prevention. OPFRs are suspected of causing potential thyroid disruption in humans. In fish, their thyroid hormone modulation is reported but the mechanisms of this modulation are less understood. Read More

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November 2018

Thyroid-Stimulating Hormone Reference Ranges in the First Trimester of Pregnancy in an Iodine-Sufficient Country.

Endocrinol Metab (Seoul) 2018 Dec;33(4):466-472

Department of Endocrinology, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.

Background: Thyroid dysfunction is associated with negative neonatal and obstetric outcomes. Large differences in thyroid function reference intervals exist across different populations. These differences can be explained by population-specific factors, such as iodine status. Read More

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December 2018
4 Reads

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism.

PLoS One 2018 4;13(12):e0208206. Epub 2018 Dec 4.

Department of Molecular Cardiology, Cleveland Clinic, Ohio, United States of America.

Background: Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.

Objective: The present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status. Read More

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December 2018
1 Read

Management of fetal goiters : 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays de Loire perinatal network.

J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.

a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.

Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More

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December 2018
3 Reads

[Variant analysis of a patient with dyshormonogenesis due to congenital hypothyroidism].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):836-839

Pediatrics Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.

Objective: To carry out variant analysis for a Chinese boy featuring dyshormonogenesis due to congenital hypothyroidism.

Methods: DNA of the patient and his parents was extracted and sequenced by high-throughput sequencing. The results were validated with Sanger sequencing and analyzed with Bioinformatics software. Read More

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December 2018
1 Read

The effect of thyroid functions on osteopenia of prematurity in preterm infants.

J Pediatr Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

Division of Neonatology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Altıntag, Ankara, Turkey.

Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Read More

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December 2018
1 Read

Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin C biomarker.

Semergen 2018 Nov 30. Epub 2018 Nov 30.

University of Hail, Department of Biology, University of Hail, Hail, Saudi Arabia.

Background: Creatinine is the most widely used renal failure biomarker; however, it has a lot of drawbacks. One of the major drawbacks is the blind range (does not increase until 50% of the kidney deteriorates). On the other hand, cystatin C has gained more attention as a promising biomarker due to several advantages over creatinine. Read More

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November 2018

Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.

Lancet 2018 Nov 30. Epub 2018 Nov 30.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, National Institute of Health Research Biomedical Research Centre, London, UK.

Background: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. Read More

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November 2018
2 Reads

Behavior in dogs with spontaneous hypothyroidism during treatment with levothyroxine.

J Vet Intern Med 2018 Nov 30. Epub 2018 Nov 30.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Thyroid hormone supplementation anecdotally has been described as a valid treatment option for dogs with aggression-related problems. However, prospective, controlled, and blinded trials evaluating behavior and neurohormonal status in hypothyroid dogs during treatment with levothyroxine are lacking.

Objective: Levothyroxine supplementation will have a significant influence on the behavior and neurohormonal status of dogs with spontaneous hypothyroidism. Read More

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November 2018

Endocrine disorders associated with hepatitis C virus chronic infection.

Rev Endocr Metab Disord 2018 Nov 29. Epub 2018 Nov 29.

Rheumatology Unit, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy.

The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic disorders, namely autoimmune thyroiditis, type 2 diabetes mellitus, and erectile/sexual dysfunctions. In this review, we summarize current knowledge on the endocrine/metabolic diseases associated with chronic HCV infection, focusing on the main concepts emerged in the recent literature in this field. Read More

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November 2018

Endocrine function and gland volume after endoscopic transsphenoidal surgery for nonfunctional pituitary macroadenomas.

Authors:

J Neurosurg 2018 Nov 1:1-10. Epub 2018 Nov 1.

OBJECTIVELoss of pituitary function due to nonfunctional pituitary adenoma (NFPA) may be due to compression of the pituitary gland. It has been proposed that the size of the gland and relative perioperative gland expansion may relate to recovery of pituitary function, but the extent of this is unclear. This study aims to assess temporal changes in hormonal function after transsphenoidal resection of NFPA and the relationship between gland reexpansion and endocrine recovery. Read More

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November 2018

Practice Variance in Thyroid Screening of Youth with Type 1 Diabetes Mellitus.

Horm Res Paediatr 2018 Nov 29:1-4. Epub 2018 Nov 29.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Variance between current American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and in clinical practice exists for the use of thyroid antibody and thyroid function screening in pediatric patients with new-onset type 1 diabetes (T1D).

Methods: North American Pediatric Endocrine Society (PES) members were surveyed regarding their thyroid screening practices of euthyroid youth with T1D. An institutional analysis of the ability of antithyroid peroxidase (aTPO) and antithyroglobulin antibodies (aTG) to predict the subsequent use of levothyroxine was performed. Read More

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November 2018
2 Reads

A Quantitative Clinical Decision-support Strategy Identifying Which Oropharyngeal Head and Neck Cancer Patients may Benefit the Most from Proton Radiation Therapy.

Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.

Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Purpose: Developing a quantitative decision-support strategy estimating the impact of normal tissue complications from definitive radiation therapy (RT) for head and neck cancer (HNC). We developed this strategy to identify oropharyngeal HNC patients that may benefit most from receiving proton RT.

Methods And Materials: Recent normal tissue complication probability (NTCP) models for dysphagia, esophagitis, hypothyroidism, xerostomia and oral mucositis were used to estimate NTCP for 33 oropharyngeal HNC patients previously treated with photon IMRT. Read More

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November 2018

WITHDRAWN: Iodine supplementation for preventing iodine deficiency disorders in children.

Cochrane Database Syst Rev 2018 Nov 29;11:CD003819. Epub 2018 Nov 29.

Researcher in Systematic Reviews, Georg-Kerschensteiner-Straße 16, Munich, Germany, 81829.

Background: Iodine deficiency is the main cause of potentially preventable mental retardation in childhood, as well as causing goitre and hypothyroidism in people of all ages. It is still prevalent in large parts of the world.

Objectives: To assess the effects of iodine supplementation overall, and of different forms and dosages of iodine supplementation separately, in the prevention of iodine deficiency disorders in children. Read More

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November 2018
1 Read

Hypothyroidism.

Authors:
Joshua Merson

JAAPA 2018 Dec;31(12):43-44

Joshua Merson is an assistant professor in the PA program at MGH Institute of Health Professions and practices in the ED at Brigham and Women's Hospital, both in Boston, Mass. The author has disclosed no potential conflicts of interest, financial or otherwise.

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December 2018

Management of thyrotoxicosis in children and adolescence: a Turkish multi-center experience.

J Clin Res Pediatr Endocrinol 2018 Nov 29. Epub 2018 Nov 29.

Gaziosmanpaşa Taksim E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.

Objective: To determine demographic and biochemical features of childhood and juvenile thyrotoxicosis and determine the treatment outcomes in them.

Methods: We reviewed records of 503 children from in 12 different cities of Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017.

Results: In all, 375 (74. Read More

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November 2018
1 Read

Posttraumatic stress disorder and incidence of thyroid dysfunction in women.

Psychol Med 2018 Nov 29:1-10. Epub 2018 Nov 29.

Department of Epidemiology,Harvard T.H. Chan School of Public Health,Boston, MA,USA.

Background: Abnormal thyroid function is prevalent among women and has been linked to increased risk of chronic disease. Posttraumatic stress disorder (PTSD) has been linked to thyroid dysfunction in some studies; however, the results have been inconsistent. Thus, we evaluated trauma exposure and PTSD symptoms in relation to incident thyroid dysfunction in a large longitudinal cohort of civilian women. Read More

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November 2018
1 Read

Prevalence of autoimmune thyroid diseases among the Turner Syndrome patients: meta-analysis of cross sectional studies.

BMC Res Notes 2018 Nov 29;11(1):842. Epub 2018 Nov 29.

Faculty of Medicine, University of Khartoum, Qasr Street, P.O. Box 11111, Khartoum, Sudan.

Objective: This meta-analysis was done to estimate the prevalence of autoimmune thyroid diseases (ATDs) in Turner Syndrome patients, and to determine the clinical status of thyroid autoimmune diseases that occur frequently in association with Turner Syndrome.

Results: A total of 18 studies were included in the meta-analysis. The pooled overall prevalence of autoimmune thyroid diseases in Turner Syndrome patients was 38. Read More

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November 2018

Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive.

Asia Pac J Clin Nutr 2018 ;27(6):1366-1373

Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health; Key Lab of Trace Elements and Human Health of Heilongjiang Province; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention; Harbin Medical University, Harbin, China.

Background And Objectives: When iodine intake is in excess, a susceptible population that has a genetic predisposition will have an increased risk of hypothyroidism or autoimmune thyroiditis. This study evaluated the vulnerability to iodine excess and subclinical thyroid disease through screening of single nucleotide polymorphisms (SNPs) in reproductive-age women to provide evidence to be used for the prevention of subclinical thyroid disease.

Methods And Study Design: In Shanxi province, four areas where a range of iodine exposures from low to high were chosen in each region, 60 women were anticipated to enrol, including 20 pregnant women, 20 lactating women, and 20 non-pregnant, non-lactating women. Read More

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January 2018

European perspective on the 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Proceedings of an interactive international symposium.

Thyroid 2018 Nov 28. Epub 2018 Nov 28.

University Hospital Essen, Department of Endocrinology and Metabolism, and Division of Laboratory Research, Essen, Germany ;

Background: The American Thyroid Association (ATA) Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. Read More

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November 2018
3 Reads

From axolotl to zebrafish: a comparative approach to the study of thyroid involvement in ocular development.

Authors:
David L Williams

Eye (Lond) 2018 Nov 27. Epub 2018 Nov 27.

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK.

While discussion of interactions between the thyroid gland and the eye mostly focus on thyroid eye disease, the involvement of the thyroid and its hormones on development of the eye before birth is also an important perspective that should not be forgotten. Experimental models involving amphibians and fish are valuable both because the developing larvae are not constrained within the adult but can be observed and manipulated as they grow autonomously and also because they metamorphose with substantial morphological changes driven by the hypothalamo-pituitary-thyroid axis occurring as they develop from eggs to adults. In this paper we will first discuss changes seen in the axolotl, a naturally occurring neotonous hypothyroid salamander and the Xenopus toad a widely used laboratory amphibian. Read More

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November 2018

Improvement of Hypothalamic Hamartoma-related Psychiatric Disorder After Stereotactic Laser Ablation: Case Report and Review of the Literature.

World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Neurosurgery, Children's Hospital of Wisconsin, Milwaukee, WI 53226. Electronic address:

Background: Hypothalamic hamartomas (HHs) are non-neoplastic congenital malformations associated with refractory epilepsy and behavioral disorders. Improvement in behavioral functioning following resection of HHs has been reported. Stereotactic laser ablation (SLA), a minimally invasive technique, has been used for the treatment of HH-related epilepsy. Read More

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November 2018
2 Reads

LHX3 deficiency presenting in the United States with severe developmental delay in a child of Syrian refugee parents.

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, California, USA.

In this case report, we present a novel mutation in Lim-homeodomain (LIM-HD) transcription factor, LHX3, manifesting as combined pituitary hormone deficiency (CPHD). This female patient was originally diagnosed in Egypt during infancy with Diamond Blackfan Anemia (DBA) requiring several blood transfusions. Around 10 months of age, she was diagnosed and treated for central hypothyroidism. Read More

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November 2018
3 Reads

The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.

The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years. Read More

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November 2018
2 Reads

Subclinical hyperthyroidism in the course of autonomous nodules - clinical evaluation.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.

Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More

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November 2018
3 Reads

Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by and Tests.

Allergy Asthma Immunol Res 2019 Jan;11(1):29-42

Group of Experimental and Clinical Allergy, IPS Universitaria, University of Antioquia, Medellín, Colombia.

Purpose: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if these IgE autoantibodies can trigger urticaria is still a matter of study. The aim of this study was to investigate the relationship between concomitant IgE autoantibodies against thyroid antigens in CSU. Read More

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January 2019
1 Read

Clinical Profile of Primary Sjogrens Syndrome with Hypokalemic Periodic Paralysis.

J Assoc Physicians India 2018 May;66(5):69-70

Chief and Consultant Rheumatologist, Center for Rheumatic Diseases, Pune, Maharashtra.

Introduction: Primary Sjogren's Syndrome (pSS) with Hypokalemic Periodic Paralysis(HPP) whether an association or a different clinical subset needs review.

Methods: Cross-sectional retrospective study of subjects of Primary Sjogren's Syndrome with Hypokalemic Periodic Paralysis(HPP) identified from database maintained at Centre For Rheumatic Diseases, Pune since 1996 with records of over 50000 patients. The diagnosis was clinical. Read More

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May 2018
4 Reads

Prevalence and Clinical Use of Anti-Thyroid Antibodies in RA Patients: A Prospective Case-Control Study.

J Assoc Physicians India 2018 May;66(5):14-17

Clinical Pharmacologist, Bangalore, Karnataka.

Aim: To evaluate the prevalence of anti-thyroid antibodies in a cohort of rheumatoid arthritis (RA) patients from south India and their clinical use.

Methods: A cross-sectional epidemiological study was conducted including 1217 patients aged more than 14 years with fever and thrombocytopenia admitted in the medical wards from October 2013 to September 2014. Detailed clinical examination and routine investigations were done; specific investigations like blood culture, widal test, antigen test for malaria, IgM ELISA leptospira, IgM ELISA dengue, bone marrow aspiration/biopsy etc. Read More

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May 2018
3 Reads

EPIDEMIOLOGICAL FEATURES OF BREAST CANCER IN THE REPUBLIC OF UZBEKISTAN.

Vopr Onkol 2016;62(4):495-8

There were analyzed epidemiological risk factors in 505 breast cancer patients receiving treatment in the Tashkent City Oncology Dispensary. The tumor was studied by the hormone-receptor status, the level of Her2/neu protein hyperexpression and proliferation index in tumor cells Ki 67. The risk of developing breast cancer was higher in women aged 40 to 60 years with the most adverse prognostic biological subtypes of breast cancer. Read More

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January 2016
2 Reads

Maternal Hypothyroidism during Pregnancy and the Risk of Pediatric Endocrine Morbidity in the Offspring.

Am J Perinatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective:  Previous studies suggested maternal hypothyroidism during pregnancy to be associated with cognitive impairment of the offspring. Scarce data exist regarding long-term endocrine health of the offspring. This study was aimed to assess whether children born to mothers with hypothyroidism during pregnancy are at an increased risk for long-term endocrine morbidity. Read More

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November 2018
5 Reads

Thyroid hormones mediate metabolic rate and oxidative, anti-oxidative balance at different temperatures in Mongolian gerbils (Meriones unguiculatus).

Comp Biochem Physiol C Toxicol Pharmacol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Oxidative damage is a potential physiological cost of thermoregulation during seasonal adjustments to air temperature (T) in small mammals. Here, we hypothesized that T affects serum thyroid hormone levels and these hormones can mediate the changes in metabolic rate and oxidative damage. Mongolian gerbils (Meriones unguiculatus) were acclimated at different Ts (5 °C, 23 °C and 37 °C) for 3 weeks. Read More

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November 2018
6 Reads

Gastrointestinal Malabsorption of Thyroxine.

Endocr Rev 2018 Nov 23. Epub 2018 Nov 23.

Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.

Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong treatment. The therapeutic efficacy of thyroxine may be marred by behavioral, pharmacologic and pathologic issues acting as interfering factors. Despite a continuous search for an optimal thyroxine treatment, a significant number of patients fail to show a complete chemical and/or clinical response to this reference dose of thyroxine. Read More

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November 2018
7 Reads

Long-term outcomes of renal function after radioactive iodine therapy for thyroid cancer according to preparation method: thyroid hormone withdrawal vs. recombinant human thyrotropin.

Endocrine 2018 Nov 23. Epub 2018 Nov 23.

Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Long-term effects of iatrogenic hypothyroidism on renal function from thyroid hormone withdrawal during radioactive iodine therapy (RAIT) have not been studied, especially in subjects with mildly impaired renal function. We compared renal function in thyroid cancer subjects according to preparation method of either thyroid hormone withdrawal (THW) or injection of recombinant human thyrotropin (rhTSH).

Methods: This retrospective study enrolled 241 thyroidectomized patients (rhTSH group, n = 87 and THW group, n = 154). Read More

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November 2018
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Adult-onset hypothyroidism increases ethanol consumption.

Psychopharmacology (Berl) 2018 Nov 23. Epub 2018 Nov 23.

Department of Psychobiology & Behavioral Sciences Methods, School of Psychology, Campus de Somosaguas, Complutense University of Madrid, 28223, Madrid, Spain.

Rationale: Only in Europe it can be estimated that more than 20 million of people would be affected by hypothyroidism in some moment of their life. Given that ethanol consumption is so frequent, it would be reasonable to ask what the consequences of ethanol consumption in those individuals affected by hypothyroidism are.

Objectives: To study the interaction between hypothyroidism and ethanol consumption. Read More

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November 2018
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Nationwide analysis of unplanned 30-day readmissions after transsphenoidal pituitary surgery.

Int Forum Allergy Rhinol 2018 Nov 23. Epub 2018 Nov 23.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.

Background: Transsphenoidal pituitary surgery has evolved into a safe procedure with shorter hospitalizations, yet unplanned readmissions remain a quality measure for which there is a paucity of data. We sought to examine rates, timing, etiologic factors, and costs surrounding readmission after transsphenoidal pituitary surgery.

Methods: The Nationwide Readmissions Database (NRD) was queried for patients who underwent transsphenoidal pituitary between January 2013 and November 2013. Read More

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November 2018
9 Reads