Search Our Scientific Publications & Authors

J Oncol Pharm Pract 2019 Mar 16:1078155219835912. Epub 2019 Mar 16.

1 Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT, USA.

Purpose: Nivolumab is a fully human IgG4 programmed death 1 immune checkpoint inhibitor (ICI) antibody that has anti-tumor activity by selectively blocking the interaction of the programmed death 1 receptor with its two known programmed death ligands PD-L1 and PD-L2. In doing so, this immune checkpoint inhibitor removes the negative signal stifling T cell activation and proliferation within the tumor microenvironment and demonstrates favorable antitumor activity.

Case Report: We report an interesting case of immune checkpoint inhibitor-induced primary hypothyroidism with associated hypothyroid myopathy in a young patient with surgically resected stage IIIB melanoma receiving adjuvant nivolumab. Read More

Medicine (Baltimore) 2018 Oct;97(43):e12938

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Rationale: Antiepileptic drugs (AEDs) are one of the causative drugs of drug-induced hypothyroidism. In most cases, AED-induced hypothyroidism is subclinical and indicated only by abnormalities of free thyroxine (T4) and/or thyroid-stimulating hormone (TSH) levels. Severe symptomatic hypothyroidism following AEDs is rarely reported in the literature. Read More

Endocrinol Diabetes Metab Case Rep 2018 26;2018. Epub 2018 Jul 26.

New Cross Hospital, Wolverhampton, UK.

Myopathy is a well-known complication of hypercortisolism and commonly involves proximal lower-limb girdle. We report a rare case of Cushing's syndrome in a 60-year-old female presenting with significant respiratory muscle weakness and respiratory failure. She had history of rheumatoid arthritis, primary biliary cirrhosis and primary hypothyroidism and presented with weight gain and increasing shortness of breath. Read More

Dtsch Med Wochenschr 2018 Aug 7;143(16):1174-1180. Epub 2018 Aug 7.

Triiodothyronine (T3) is a key regulator of bone, muscle and articular cartilage. Musculoskeletal symptoms of hyperthyroidism include loss of bone mass finally leading to osteoporosis and weakness of the skeletal musculature. Hypothyroidism on the other side frequently leads to muscle stiffness and cramping and, occasionally, results in rhabdomyolysis. Read More

Georgian Med News 2018 Jun(279):155-161

Tbilisi State Medical University, Department of Pharmacotherapy, Georgia.

The review analyzes the literature data, which covers the intolerance of statins associated with myopathy. The article gives a definition of statin intolerance, analyzed data from a randomized, controlled trials, where are indicated frequency of statin-associated myopathy, its symptoms in juxtaposition with an increase in creatine kinase activity. It is noted that the frequency of complications depends on the applied statin, its dose, duration, the use of other risk factors that contribute to the development of myopathy. Read More

Rev Med Brux 2018;39(3):172-174

Service de Médecine interne, Hôpital La Rabta.

Hypothyroidism is exceptionnally revealed by hypertrophic myopathy, known as Hoffmann syndrome. We report two new cases of severe hypothyroidism presenting as hypertrophic myopathy, occurring in two men of 49 and 57 years-old. Read More

Diabet Med 2018 10;35(10):1457-1459

Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Trust, London, UK.

Background: Hereditary Neuropathy with liability to Pressure Palsies (HNPP) is an autosomal dominant neuropathy, associated with deletion of the Peripheral Myelin Protein-22 (PMP-22) gene, causing recurrent painless palsies with age of onset between 10 and 30 years old. Only a few cases of Type 2 Diabetes and HNPP have been described and the coexistence of HNPP and Type 1 diabetes has never been reported.

Case Report: A 54-year old man with a history of Type 1 diabetes, managed with continuous subcutaneous insulin infusion (CSII), presented with deterioration of long-standing motor and sensory symptoms, previously attributed to golfer's elbow, diabetic neuropathy and spinal degenerative disease. Read More

J Med Case Rep 2018 May 22;12(1):143. Epub 2018 May 22.

Department of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Rhabdomyolysis is a rare but serious complication of lipid-lowering therapy. Statin and fibrate combination increases the risk of rhabdomyolysis possibly by pharmacodynamic interactions. Advanced age, diabetes, hypothyroidism, polypharmacy, and renal impairment are known to increase the risk of rhabdomyolysis. Read More

Rinsho Shinkeigaku 2018 May 28;58(5):308-313. Epub 2018 Apr 28.

Department of Radiotherapy, Sakai City Medical Center.

We report the case of a 50-year-old female survivor of Hodgkin lymphoma (HL), who developed dropped head syndrome (DHS). The patient was diagnosed with HL at 20 years of age, and underwent chemo-radiotherapy, which led to complete remission. Undergoing supplemental therapy for post-radiation hypothyroidism, she had twin babies. Read More

Indian J Clin Biochem 2018 Apr 5;33(2):222-228. Epub 2017 May 5.

1Department of Physiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan 342005 India.

Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. Read More

Int J Environ Res Public Health 2018 04 9;15(4). Epub 2018 Apr 9.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia 06132, Italy.

Autoimmune hypothyroidism (Hashimoto thyroiditis; HT) is the most common postnatal thyroid disease. Clinical manifestations of HT vary according to disease severity. Due to the pleiotropic effects of thyroid hormone, less common signs and symptoms of HT can occur, leading to a delay in diagnosis. Read More

Medicine (Baltimore) 2018 Apr;97(14):e0318

Department of Endocrinology, Benxi Central Hospital, Liaoning, People's Republic of China.

Rationale: Fenofibrate is a fibric acid derivative indicated for use in hypertriglyceridemia and mixed dyslipidemia treatment among adults. Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle contents into the systemic circulation, which is the most serious and fatal side effect of fenofibrate. The objective of this paper is to discuss fatal side effect of fenofibrate and keep safe medication. Read More

Am J Case Rep 2018 Mar 11;19:277-283. Epub 2018 Mar 11.

Department of Internal Medicine, Riverside University Health System, Moreno Valley, CA, USA.

BACKGROUND Chronic intake of high-dose corticosteroids is associated with multiple adverse clinical effects, including hypertension, insulin resistance, impaired wound healing, immunosuppression, myopathy, and osteoporosis. In cases of autoimmune disease, use of steroid-sparing treatment modalities is preferred over chronic steroid therapy to limit these side effects. Glucocorticoid-induced myopathy is a less common side effect of chronic steroid use in patients treated with <10 mg/day of prednisone. Read More

Rinsho Ketsueki 2018;59(2):161-166

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences.

A 40-year-old female presented with a skin rash, hepatosplenomegaly, hypothyroidism, IgG-λ monoclonal gammopathy, slightly elevated serum VEGF levels, and >1-year history of weakness in the posterior cervical muscles. Based on these symptoms and her clinical course, she was suspected of having POEMS syndrome. However, because there was no sign of peripheral neuropathy (PN), the criteria for the diagnosis of POEMS syndrome were not met. Read More

BMJ Case Rep 2018 Feb 12;2018. Epub 2018 Feb 12.

Department of Neurology, Baby Memorial Hospital, Calicut, Kerala, India.

Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. Read More

eNeurologicalSci 2017 Mar 4;6:16-20. Epub 2016 Nov 4.

Department of Neurology, Tongji University Affiliated Tenth People's Hospital, 200072 Shanghai, PR China.

Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a clinical syndrome associated with mitochondrial disorders (MIDs). This report illustrates a case of MELAS syndrome with hypothyroidism and psychiatric disorders, which is different from the common clinical manifestations of MELAS syndrome, such as exercise intolerance, migraine-like headaches, hearing loss and seizures etc. There are considerable interests in the possibility that mitochondrial dysfunction may play a role in the pathogenesis of endocrine dysfunctions and psychiatric disorders in MELAS syndrome. Read More

J Neurol Sci 2017 12 13;383:53-55. Epub 2017 Oct 13.

Neurology Division, Internal Medicine Department, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.

Clin Endocrinol (Oxf) 2018 Mar 20;88(3):460-467. Epub 2017 Dec 20.

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.

Background: Irisin is a new adipo-myokine, encoded by the FNDC5 gene. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This prospective study assesses the influence of thyrometabolic changes on serum irisin concentration in association with altered muscle metabolism. Read More

Bull Hosp Jt Dis (2013) 2017 May;75(3):198-200

Trigger finger is a common cause of hand pain in the adult population. Studies in the past have suggested that ring finger and thumb are the most prevalent trigger fingers. Risk factors, such as diabetes and hypothyroidism, have been reportedly linked to trigger fingers. Read More

JAMA Neurol 2017 10;74(10):1216-1222

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Importance: Neurological complications are an increasingly recognized consequence of the use of anti-programmed death 1 (PD-1) antibodies in the treatment of solid-organ tumors, with an estimated frequency of 4.2%. To date, the clinical spectrum and optimum treatment approach are not established. Read More

Curr Opin Rheumatol 2017 Nov;29(6):618-622

Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Expression, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Purpose Of Review: To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy.

Recent Findings: Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscle biopsies. Inclusion body myositis is frequently misdiagnosed as polymyositis when rimmed vacuoles are absent on muscle biopsy, and a careful neuromuscular evaluation is not performed. Read More

Am J Case Rep 2017 Aug 22;18:912-918. Epub 2017 Aug 22.

Department of Medicine, Riverside University Health System, Moreno Valley, CA, USA.

BACKGROUND Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with symptomatic hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients with hypothyroidism who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified. CASE REPORT We report a case of a 52-year-old Hispanic woman with a history of hypothyroidism, hypertension, and type 2 diabetes mellitus who presented with fatigue, severe generalized weakness, bilateral leg pain, and recurrent falls. Read More

Indian J Gastroenterol 2017 Jul 1;36(4):313-317. Epub 2017 Aug 1.

Department of Gastroenterology, Gleneagles Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.

Health-related quality of life (HRQOL) is influenced by the disease state, associated complications and their management. In patients with liver cirrhosis co-morbidity, severity of liver disease and their complications are likely to affect the QOL. The aim of the study was to determine the factors that are likely to influence the domains of HRQOL using SF-36 in patients with liver cirrhosis. Read More

Medicine (Baltimore) 2017 Jul;96(30):e7591

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Myalgia and elevated creatine kinase (CK) are occasionally observed during the treatment of hyperthyroid patients. Relative hypothyroidism resulted from rapid thyroid hormone reduction had been promoted as a plausible cause of these myopathic changes, however rarely reported.

Patient Concerns: We hereby presented a 20-year-old female with Grave's disease, who developed myopathy and elevated CK during rapid correction of thyroid hormone. Read More

J Med Genet 2017 10 22;54(10):710-720. Epub 2017 Jul 22.

Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council, Naples, Italy.

Background: The laminin alpha 5 gene () plays a master role in the maintenance and function of the extracellular matrix (ECM) in mammalian tissues, which is critical in developmental patterning, stem cell niches, cancer and genetic diseases. Its mutations have never been reported in human disease so far. The aim of this study was to associate the first mutation in gene to a novel multisystem syndrome. Read More

J Clin Diagn Res 2017 May 1;11(5):OL01-OL02. Epub 2017 May 1.

Associate Professor, Department of Internal Medicine, Kasturba Medical College, Affiliated to Manipal University, Mangalore, Karnataka, India.

Hand (N Y) 2017 07 5;12(4):357-361. Epub 2016 Dec 5.

1 University of Rochester, NY, USA.

Background: Although surgery can provide definitive treatment for de Quervain's tenosynovitis, nonoperative treatment could be preferable if symptoms are predictably relieved. We sought to determine the effectiveness of corticosteroid injections as treatment for de Quervain's tenosynovitis and to evaluate patient characteristics as predictors of treatment outcome.

Methods: A retrospective study was conducted using our institutional database International Classification of Disease, version 9 (ICD-9) code list for de Quervain's tenosynovitis. Read More

Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.

Departments of Endocrinology.

We present the case of a thirty-year-old female patient who was referred to the endocrinology team with an enlarging goitre and biochemical hypothyroidism. She had been dependent on total parenteral nutrition for the previous six years as a result of intestinal failure thought to be caused by possible underlying mitochondrial disease. The patient also suffers from a Desmin myopathy, and at present, the exact aetiology behind her intestinal failure is not certain. Read More

Semergen 2018 Mar 3;44(2):135-137. Epub 2017 Jun 3.

Medicina Familiar y Comunitaria, CAP Guineueta, Atención Primaria, Institut Català de la Salut, Barcelona, España.

The dropped head syndrome, whether due to muscle weakness, rigidity, or ankylosis, is not uncommon in the elderly. It is characterised by a "chin-on-chest" reducible kyphosis, which is secondary to head muscle debility. It may be associated with a neuromuscular group of diseases such as polymyositis, chronic Inflammatory demyelinating polyneuropathy, myasthenia gravis, amyotrophic lateral sclerosis, and inclusion-body myositis. Read More

Case Rep Neurol 2017 Jan-Apr;9(1):69-75. Epub 2017 Apr 24.

Private Office, Vienna, Austria.

Background: Eosinophilia has not been reported as a manifestation of a mitochondrial disorder (MID). Here, we report a patient with clinical features suggesting a MID and permanent eosinophilia, multisystem disease, and progressive hyper-creatine-kinase (CK)-emia for at least 10 years.

Materials And Methods: Methods applied included a clinical exam, blood chemical investigations, electrophysiological investigations, imaging, and invasive cardiological investigations. Read More

Pediatr Endocrinol Rev 2016 Dec;14(2):147-158

Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA.

This review highlights the presentations of myopathy in children in both hypothyroid and hyperthyroid states with an emphasis on the pathophysiology, diagnosis and treatment. Based on our review of the literature data, myopathy should be considered in all children presenting with muscular weakness or altered muscle enzymes in the context of thyroid disease. Read More

SAGE Open Med Case Rep 2017 10;5:2050313X17703021. Epub 2017 Apr 10.

Center of Medical Genetics, Medical University of Innsbruck, Innsbruck, Austria.

Objectives: A mild, slowly progressive course of proximal myotonic myopathy, also known as myotonic dystrophy type 2, over years allowing the patient to continue with extreme sport activity, has been only rarely reported.

Methods: Case report.

Results: The patient is a 54-year-old female sport teacher who developed myotonia of the distal upper limbs at the age of 32 years. Read More

J Endocrinol Invest 2017 Oct 22;40(10):1099-1106. Epub 2017 Apr 22.

Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, Ospedale di Circolo, Viale Borri, 57, 21100, Varese, Italy.

Objective: Hypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests.

Materials And Methods: Fifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo). Read More

Turk J Ophthalmol 2017 Apr 1;47(2):94-105. Epub 2017 Apr 1.

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves' disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood. Autoimmunity against putative antigens shared by the thyroid and the orbit plays a role in the pathogenesis of disease. Read More

J Clin Exp Hepatol 2017 Mar 15;7(1):66-67. Epub 2016 Sep 15.

Medanta Liver Institute, Medanta The Medicity, Gurgaon, Delhi (NCR), India.

Statins are commonly used drugs in patients with liver and cardiac disease. Statin-induced severe myopathy is a very uncommon presentation and rhabdomyolysis may occur in extreme cases which leads to renal failure. Patients with comorbidities like diabetes, hypothyroidism, and liver disease have higher chances of development of statin-induced myopathy. Read More

Int J Surg Case Rep 2017 27;33:79-83. Epub 2017 Feb 27.

University of Vermont Medical Center, Department of Surgery, 111 Colchester Avenue, Burlington, VT, 05401, United States. Electronic address:

Purpose: Atrophic visceral myopathy is a pathological diagnosis characterized by atrophy of the smooth muscle layers of the viscera with intact ganglia. Rarely, it can present acutely as an intestinal pseudo-obstruction. We describe a rare case report and explore how this diagnosis can be distinguished from other forms of intestinal obstruction. Read More

Pharmacol Ther 2017 Jul 14;175:1-16. Epub 2017 Feb 14.

Clinique de Prévention Cardiovasculaire, Institut de Recherche Clinique de Montréal, Canada; Département de nutrition, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada.

Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia; however, they cause frequent undesirable side effects. The incidence of statin-induced myotoxicity (SIM) is presented by 7 to 29% of patients, depending upon the report. SIM may develop in presence of abnormally high concentrations of statins in the myocyte and/or in presence of muscular conditions that may predispose to SIM. Read More

Am J Emerg Med 2017 Jun 23;35(6):937.e5-937.e6. Epub 2016 Dec 23.

Endocrinology, Diabetes and Metabolism fellowship, Cooper University Hospital, United States.

Acute compartment syndrome is increased tissue pressure exceeding perfusion pressure in a closed compartment resulting in nerve and muscle ischemia. Common precipitating causes are crush injuries, burns, substance abuse, osseous or vascular limb trauma. This is a case of 42year old female with history of hypothyroidism who presented to emergency room with acute onset of severe pain and swelling in right lower extremity. Read More

Continuum (Minneap Minn) 2016 Dec;22(6, Muscle and Neuromuscular Junction Disorders):1815-1828

Purpose Of Review: This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies.

Recent Findings: Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasis, which can cause a myosin-loss myopathy. Read More

Int J Rheum Dis 2017 Jun 30;20(6):685-690. Epub 2016 Nov 30.

Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: Fibromyalgia syndrome (FMS) is defined as chronic widespread pain that cannot be accounted for by any other medical disorder. Our aim was to explore the prevalence of thyroid autoimmunity in patients with FMS.

Methods: For determining thyroid function in 207 FMS patients, we tested for the titers of free tri-iodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and anti-TSH receptor antibody (TRAb). Read More

Acta Cardiol Sin 2016 Nov;32(6):631-639

Department of Medicine (Monash Medical Centre), Monash University and Monash Health, 246 Clayton Road, Clayton, 3168 VIC, Australia.

Background: Hydroxymethyl glutaryl coenzyme A reductase inhibitors, commonly called statins, are some of the most commonly prescribed medications worldwide. Evidence suggests that statin therapy has significant mortality and morbidity benefit for both primary and secondary prevention from cardiovascular disease. Nonetheless, concern has been expressed regarding the adverse effects of long term statin use. Read More

Clujul Med 2016 20;89(4):459-463. Epub 2016 Oct 20.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

The control mechanisms of respiration as a vital function are complex: voluntary - cortical, and involuntary - metabolic, neural, emotional and endocrine. Hormones and hypothalamic neuropeptides (that act as neurotrasmitters and neuromodulators in the central nervous system) play a role in the regulation of respiration and in bronchopulmonary morphology. This article presents respiratory manifestations in adult endocrine diseases that evolve with hormone deficit or hypersecretion. Read More

Intern Med 2016;55(21):3185-3190. Epub 2016 Nov 1.

Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan.

A 39-year-old woman with a 3-year history of a rounded face developed widespread myalgia. Detailed examinations revealed no disorders that could explain the pain other than concomitant Cushing's disease and central hypothyroidism. Both the hypercortisolemia and hypothyroidism completely resolved after the patient underwent surgery to treat Cushing's disease, but she continued to experience unresolved myalgia and met the diagnostic criteria for fibromyalgia. Read More

J Clin Neurophysiol 2017 Mar;34(2):139-143

*Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey; †Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Trakya University, Edirne, Turkey; ‡Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey; and §Department of Neurology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.

Purpose: The aim of this study was to determine whether there are electrodiagnostic differences between carpal tunnel syndrome (CTS) patients with diabetes mellitus, CTS + hypothyroidism (HT), CTS + fibromyalgia syndrome, CTS + rheumatoid arthritis (RA), and idiopathic CTS cases, by comparing nerve conduction studies.

Methods: This research examined electrophysiologic studies of 47 untreated HT + CTS, 47 diabetes mellitus + CTS, 49 RA + CTS, 52 fibromyalgia syndrome + CTS, 50 idiopathic CTS cases, and a healthy control group of 50 individuals (a total of 293 patients and 433 hands with CTS).

Results: There were no significant differences between the groups in terms of sex and age. Read More

J Assoc Physicians India 2016 05;64(5):52-58

Asst. Professor, Post graduate Department of Medicine and Dept. of Neurology, VSS Institute of Medical Science and Research (VIMSAR), Burla, Orissa.

Objective: To study the clinical profile of hypokalemic flaccid paralysis (HKFP) and to evaluate its causes.

Methods: Fifty cases of hypokalemic flaccid paralysis (HKFP) admitted between November 2012 to October 2014 were taken up in the study. Serum potassium level < 3. Read More

J Paediatr Child Health 2016 Aug;52(8):852-3

Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Prog Cardiovasc Dis 2016 Sep - Oct;59(2):153-164. Epub 2016 Aug 3.

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.

Statin intolerance is a commonly encountered clinical problem for which useful management strategies exist. Although many patients report statin-related muscle symptoms, studies indicate that the majority of these patients can tolerate a statin upon re-challenge. Alternative statin dosing strategies are an effective way to modify and reintroduce statin therapy for patients reporting adverse symptoms. Read More

Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):244-51

This article contains bibliographical data concerning the rheumatic clinical manifestations in hypothyroidism: polyarthralgias, lack of recent skill of fine movements of the hands, carpal tunnel syndrome or tarsal, degenerative arthropathy or acute type (gout, chondrocalcinosis), adhesive capsulitis (frozen shoulder syndrome), generalized muscular stiffness, hypothyroid myopathy, secondary osteoarthritis, Dupuytren's contracture, "trigger finger" (also called as stenosing tenosynovitis or trigger thumb) etc. and data on the short history, epidemiology, of these disorders. Review include 60 bibliographical sources. Read More

Oncotarget 2016 Aug;7(33):52810-52817

Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.

While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic castration resistant prostate cancer (mCRPC) showed no evidence of activity. Here we report unexpected antitumor activity seen in mCRPC patients treated with the anti-PD-1 antibody pembrolizumab. Patients with evidence of progression on enzalutamide were treated with pembrolizumab 200 mg IV every 3 weeks for 4 doses; pembrolizumab was added to standard dose enzalutamide. Read More