Search our Database of Scientific Publications and Authors

I’m looking for a

    41583 results match your criteria Hypothermia

    1 OF 832

    [A prospective, randomized, double-blinded control study on comparison of tramadol, clonidine and dexmedetomidine for post spinal anesthesia shivering].
    Rev Bras Anestesiol 2017 May 22. Epub 2017 May 22.
    SRM Medical College Hospital and Research Centre, Department of Anesthesia, Chennai, Tamilnadu, India.
    Introduction: Shivering, a common intraoperative problem under spinal anesthesia increases the oxygen consumption considerably and is uncomfortable and distressing to the patient, anesthesiologist as well as surgeon. The present study was designed to explore the effectiveness of tramadol, clonidine and dexmedetomidine in the treatment of post spinal anesthesia shivering and to look for their adverse effects.

    Methods: This prospective, randomized, double blinded control study was done on 90 patients who developed shivering under spinal anesthesia. Read More

    Exposure to febrile-range hyperthermia potentiates Wnt signalling and epithelial-mesenchymal transition gene expression in lung epithelium.
    Int J Hyperthermia 2017 Apr 26:1-10. Epub 2017 Apr 26.
    a Department of Medicine , University of Maryland School of Medicine , Baltimore , MD , USA.
    Background: As environmental and body temperatures vary, lung epithelial cells experience temperatures significantly different from normal core temperature. Our previous studies in human lung epithelium showed that: (i) heat shock accelerates wound healing and activates profibrotic gene expression through heat shock factor-1 (HSF1); (ii) HSF1 is activated at febrile temperatures (38-41 °C) and (iii) hypothermia (32 °C) activates and hyperthermia (39.5 °C) reduces expression of a subset of miRNAs that target protein kinase-Cα (PKCα) and enhance proliferation. Read More

    Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature.
    Case Rep Endocrinol 2017 2;2017:4285457. Epub 2017 May 2.
    Endocrinology, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.
    Myxedema crisis is a life-threatening extreme form of hypothyroidism with a high mortality rate if left untreated. Myxedema crisis is commonly seen in older patients, especially in women, and is associated with signs of hypothyroidism, hypothermia, hyponatraemia, hypercarbia, and hypoxemia. Patients might present with different organ specific symptoms. Read More

    Development of the Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR-CAT) Clinical Trial.
    J Trauma Acute Care Surg 2017 May 22. Epub 2017 May 22.
    University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD Department of Surgery, University of Michigan, Ann Arbor, MI Department of Surgery, Emory University, Atlanta, GA University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA Department of Surgery, University of Pittsburgh, Pittsburgh, PA Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
    Background: Patients who suffer a cardiac arrest from trauma rarely survive, even with aggressive resuscitation attempts, including an Emergency Department (ED) thoracotomy. Emergency Preservation and Resuscitation (EPR) was developed to utilize hypothermia to buy time to obtain hemostasis before irreversible organ damage occurs. Large animal studies have demonstrated that cooling to tympanic membrane temperature 10°C during exsanguination cardiac arrest can allow up to 2 hours of circulatory arrest and repair of simulated injuries with normal neurologic recovery. Read More

    Myxedema coma: A case report of pediatric emergency care.
    Medicine (Baltimore) 2017 May;96(21):e6952
    aPediatric Critical Care Medicine, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine bDepartment of Pediatric Endocrinology/Genetics, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai, China.
    Raionale: Myxedema coma (MC) is extremely rare but lethal in pediatric patients with hypothyroidism leading to altered mental status and hypothermia. But there is no clinical guideline for such cases.

    Patient Concerns: A 6-year-old Chinese girl presented with coma and hypothermia preceded by pneumonia. Read More

    TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3.
    Sci Rep 2017 May 23;7(1):2295. Epub 2017 May 23.
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, 606-8507, Japan.
    Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are structurally related to hnRNPs and upregulated in response to moderately low temperatures in mammalian cells. Although contributions of splicing efficiency, the gene promoters activated upon mild hypothermia and the transcription factor Sp1 to induction of CIRP have been reported, precise mechanisms by which hypothermia and other stresses induce the expression of mammalian cold-inducible proteins (CIPs) are poorly understood. By screening the serine/arginine-rich splicing factors (SRSFs), we report that the transcript and protein levels of SRSF5 were increased in mammalian cells cultured at 32 °C. Read More

    Comparison of 3 Methods for Preventing Perianesthetic Hypothermia in Callimicos (Callimico goeldii).
    J Am Assoc Lab Anim Sci 2017 May;56(3):318-321
    Chicago Zoological Society, Brookfield Zoo, Brookfield, Illinois, University of Illinois, College of Veterinary Medicine, Urbana, Illinois.
    Perianesthetic hypothermia is one of the most common complications in veterinary anesthesia, especially in small patients with a large body surface area to mass ratio. During anesthesia, body heat can be lost through 4 mechanisms-radiation, convection, conduction, and evaporation-but anesthetists frequently address only one mechanism at a time. Here we sought to evaluate 3 methods of preventing perianesthetic hypothermia in callimicos (Callimico goeldii). Read More

    Functional outcome of patients with prolonged hypoglycemic encephalopathy.
    Ann Intensive Care 2017 Dec 22;7(1):54. Epub 2017 May 22.
    Service de Réanimation médicale, Hôpital Central, CHU de Nancy, Av. de Lattre de Tassigny, 54035, Nancy Cedex, France.
    Background: Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy.

    Methods: In a multicenter retrospective study conducted in patients hospitalized from July 1, 2004, to July 1, 2014, we investigated functional long-term prognosis and identified prognosis factors of patients admitted in an intensive care unit (ICU) with prolonged neurological manifestations related to hypoglycemia. Eligible patients were adults admitted to the ICU with a Glasgow Coma Score <8 due to hypoglycemia and persistent consciousness disorders after normalizing blood glucose levels. Read More

    The mouse thermoregulatory system: Its impact on translating biomedical data to humans.
    Physiol Behav 2017 May 19. Epub 2017 May 19.
    Toxicity Assessment Division, National Health Effects and Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address:
    The laboratory mouse has become the predominant test species in biomedical research. The number of papers that translate or extrapolate data from mouse to human has grown exponentially since the year 2000. There are many physiological and anatomical factors to consider in the process of extrapolating data from one species to another. Read More

    Measurements of rates of cooling of a manikin insulated with different mountain rescue casualty bags.
    Extrem Physiol Med 2017 20;6. Epub 2017 Apr 20.
    Edale Mountain Rescue Team, Hope Cement, Hope Works, Hope, Derbyshire, S33 6RP UK.
    Background: Accidental hypothermia is common in those who sustain injuries in remote environments. This is unpleasant and associated with adverse effects on subsequent patient outcomes. To minimise further heat loss, a range of insulating systems are available to mountain rescue teams although the most effective and cost-efficient have yet to be determined. Read More

    Body temperature responses to handling stress in wintering Black-capped Chickadees (Poecile atricapillus L.).
    Physiol Behav 2017 May 18. Epub 2017 May 18.
    Département de biologie, chimie et géographie, Groupe de recherche sur les environnements nordiques BORÉAS, Centre d'Etudes Nordiques, Centre de la Science de la Biodiversité du Québec, Université du Québec à Rimouski, Rimouski, Canada.
    Body temperature variation in response to acute stress is typically characterized by peripheral vasoconstriction and a concomitant increase in core body temperature (stress-induced hyperthermia). It is poorly understood how this response differs between species and within individuals of the same species, and how it is affected by the environment. We therefore investigated stress-induced body temperature changes in a non-model species, the Black-capped Chickadee, in two environmental conditions: outdoors in low ambient temperature (mean: -6. Read More

    C-GRApH: A Validated Scoring System for Early Stratification of Neurologic Outcome After Out-of-Hospital Cardiac Arrest Treated With Targeted Temperature Management.
    J Am Heart Assoc 2017 May 20;6(5). Epub 2017 May 20.
    Department of Cardiovascular Medicine, University of Virginia, Charlottesville, VA
    Background: Out-of-hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post-OHCA remains difficult in patients receiving targeted temperature management.

    Methods And Results: Retrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32-34°C) for 24 hours at a tertiary-care center from 2008 to 2012 (development cohort, n=122). Read More

    The Optimal Time and Method for Surgical Prewarming: A Comprehensive Review of the Literature.
    J Perianesth Nurs 2017 Jun 1;32(3):199-209. Epub 2016 Sep 1.
    Purpose: Inadvertent hypothermia is a common problem in the operating room. This can contribute to many unfavorable outcomes --rising costs, increased complications, and higher morbidity rates.

    Design: This review determined the optimal method and time to prewarm a surgical patient to prevent perioperative hypothermia. Read More

    "Keeping Them Warm"-A Randomized Controlled Trial of Two Passive Perioperative Warming Methods.
    J Perianesth Nurs 2017 Jun 9;32(3):188-198. Epub 2016 Jul 9.
    Purpose: Inadvertent perioperative hypothermia is a common problem for patients undergoing surgery. Heat redistribution from the body's core to the periphery after induction of anesthesia is the major contributor.

    Design: A prospective randomized controlled trial was conducted to determine if reflective blankets are more effective than cotton blankets in reducing the core-peripheral temperature gradient and increasing peripheral compartment heat content during the preoperative phase among adult patients undergoing elective surgery of less than 1 hour. Read More

    Surface heparinization and blood compatibility modification of small intestinal submucosa (SIS) for small-caliber vascular regeneration.
    Biomed Mater Eng 2017 ;28(3):213-222
    Institute of Biological Science and Biotechnology, Donghua University, Shanghai 200051, China.
    Objectives: This study aims to investigate the small intestinal submucosal (SIS) surface after heparinization with the hypothermia plasma technique, to improve the blood compatibility of SIS, and to explore the possibility of construction of small-caliber vascular grafts with modified SIS scaffolds in vivo.

    Methods: SIS films prepared from jejunums of pigs were processed for surface treatment at different time periods with the argon plasma initiation technique under vacuum, and were then immediately immersed in 4% (m/v) heparin sodium solution for 24-h heparinization. The surface morphologies of heparinized SIS were observed under a scanning electron microscope (SEM). Read More

    Transapical aortic perfusion using a deep hypothermic procedure to prevent dissecting lung injury during re-do thoracoabdominal aortic aneurysm surgery.
    J Cardiothorac Surg 2017 May 19;12(1):32. Epub 2017 May 19.
    Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, University of the Ryukyus, Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
    Background: Avoiding various complications is a challenge during re-do thoracoabdominal aneurysm surgery.

    Case Presentation: A 56-year-old man had undergone surgery for type I aortic dissection four times. The residual thoracoabdominal aortic aneurysm that had severe adhesions to lung parenchyma was resected. Read More

    Evaluation of conventional and frozen elephant trunk techniques on spinal cord blood flow in an animal model†.
    Eur J Cardiothorac Surg 2017 May 18. Epub 2017 May 18.
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany.
    Objectives: The treatment of patients with extensive thoracic aortic disease involving the arch and descending aorta is often performed using the frozen elephant trunk technique (FET). Spinal cord blood flow (SCBF) in cervical, thoracic and lumbar sections prior, during and after aortic arch surgery were compared in conventional elephant trunk (cET) and FET technique in a pig model.

    Methods: German Landrace pigs (75-85 kg) underwent aortic arch surgery using the FET ( n  = 8) or cET ( n  = 8) techniques. Read More

    Enhanced Recovery After Surgery for Suspected Ovarian Malignancy: A Survey of Perioperative Practice Among Gynecologic Oncologists in Australia and New Zealand to Inform a Clinical Trial.
    Int J Gynecol Cancer 2017 Jun;27(5):1046-1050
    *NHMRC Clinical Trials Centre, University of Sydney; and †Australian New Zealand Gynecological Oncology Goup (ANZGOG), Camperdown; and ‡Crown Princess Mary Cancer Centre, Westmead Hospital, Wentworthville, New South Wales, Australia; §Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; ∥Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway; ¶Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand; and **Department of Gynaecological Oncology, Westmead Hospital, Wentworthville, New South Wales, Australia.
    Objectives: The objective of this survey was to review the current standard of perioperative care of patients with suspected advanced ovarian cancer in Australia and New Zealand in order to determine the level of equipoise for specific interventions.

    Methods: In May 2016, a web-based questionnaire (SurveyMonkey Inc, Palo Alto, CA) was sent to all gynecologic oncologists in Australia and New Zealand (n = 56). Descriptive statistics were used. Read More

    Comparison of early sequential hypothermia and delayed hypothermia on neurological function after resuscitation in a swine model.
    Am J Emerg Med 2017 May 11. Epub 2017 May 11.
    Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, China. Electronic address:
    Background: We utilized a porcine cardiac arrest model to compare early sequential hypothermia (ESH) with delayed hypothermia (DH) and no hypothermia (NH) to investigate the different effects on cerebral function after resuscitation.

    Methods: After return of spontaneous circulation (ROSC), resuscitated 24 pigs divided into three groups. The ESH group implemented early sequential hypothermia immediately, and the DH group implemented delayed hypothermia at 1 h after ROSC. Read More

    Intracoronary Hypothermia Before Reperfusion to Reduce Reperfusion Injury in Acute Myocardial Infarction: A Novel Hypothesis and Technique.
    Ther Hypothermia Temp Manag 2017 May 18. Epub 2017 May 18.
    1 Department of Cardiology, Catharina Hospital , Eindhoven, the Netherlands .
    Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients. Read More

    Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia.
    J Neurooncol 2017 May 17. Epub 2017 May 17.
    BrainTech Lab, INSERM U1205, CEA, Grenoble, France.
    Surgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Read More

    Preoperative Warming Versus no Preoperative Warming for Maintenance of Normothermia in Women Receiving Intrathecal Morphine for Cesarean Delivery: A Single Blinded, Randomized Controlled Trial.
    Anesth Analg 2017 May 12. Epub 2017 May 12.
    From the *Mater Health Services, Raymond Terrace, South Brisbane, Australia; †School of Nursing, Faculty of Health, Queensland University of Technology, Kelvin Grove, Australia; ‡Australian Centre for Health Services Innovation (AusHI), School of Public Health and Social Work/Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia; §University of Queensland, St Lucia, Brisbane, Australia; and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia.
    Background: Rates of hypothermia for women undergoing spinal anesthesia for cesarean delivery are high and prevention is desirable. This trial compared the effectiveness of preoperative warming versus usual care among women receiving intrathecal morphine, which is thought to exacerbate perioperative heat loss.

    Methods: A prospective, single-blinded, randomized controlled trial compared 20 minutes of forced air warming (plus intravenous fluid warming) versus no active preoperative warming (plus intravenous fluid warming) in 50 healthy American Society of Anesthesiologists graded II women receiving intrathecal morphine as part of spinal anesthesia for elective cesarean delivery. Read More

    Technical Note: System for Evaluating Local Hypothermia as a Radioprotector of the Rectum in a Small Animal Model.
    Med Phys 2017 May 17. Epub 2017 May 17.
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
    Purpose: The protective effects of induced or even accidental hypothermia on the human body are widespread with several medical uses currently under active research. In vitro experiments using human cell lines have shown hypothermia provides a radioprotective effect that becomes more pronounced at large, single-fraction doses common to stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) treatments. This work describes the development of a system to evaluate local hypothermia for a radioprotive effect of the rat rectum during a large dose of radiation relevant to prostate SBRT. Read More

    Routine Laboratory Indices as Predictor of Neurological Recovery in Post-Resuscitation Syndrome Patients Treated with Therapeutic Hypothermia.
    Isr Med Assoc J 2017 May;19(5):296-299
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Hypothermia is associated with improved outcome in selected survivors of cardiac arrest but no single metric enables proper prediction of neurological outcome.

    Objectives: To explored the association between routine laboratory indices of patients treated by hypothermia for cardiac arrest and their neurological outcome.

    Methods: We retrospectively collected data from survivors of cardiac arrest treated with hypothermia for 24 hours and grouped them according to their neurological outcome to either "poor" or "favorable". Read More

    Insufficient Humidification of Respiratory Gases in Patients Who Are Undergoing Therapeutic Hypothermia at a Paediatric and Adult Intensive Care Unit.
    Can Respir J 2017 20;2017:8349874. Epub 2017 Apr 20.
    Department of Paediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.
    For cooled newborn infants, humidifier settings for normothermic condition provide excessive gas humidity because absolute humidity at saturation is temperature-dependent. To assess humidification of respiratory gases in patients who underwent moderate therapeutic hypothermia at a paediatric/adult intensive care unit, 6 patients were studied over 9 times. Three humidifier settings, 37-default (chamber-outlet, 37°C; Y-piece, 40°C), 33. Read More

    Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
    J Physiol Sci 2017 May 15. Epub 2017 May 15.
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
    Central adenosine A1-receptor (A1AR)-mediated signals play a role in the induction of hibernation. We determined whether activation of the central A1AR enables rats to maintain normal sinus rhythm even after their body temperature has decreased to less than 20 °C. Intracerebroventricular injection of an adenosine A1 agonist, N6-cyclohexyladenosine (CHA), followed by cooling decreased the body temperature of rats to less than 20 °C. Read More

    COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction.
    EuroIntervention 2017 May 17. Epub 2017 May 17.
    University Medical Center Ljubljana, Ljubljana, Slovenia.
    Aims: We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest.

    Methods And Results: A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20. Read More

    A Novel Cooling Method and Comparison of Active Rewarming of Mildly Hypothermic Subjects.
    Wilderness Environ Med 2017 May 11. Epub 2017 May 11.
    Department of Biology, Stanford University (Drs Grahn and Heller).
    Objective: To compare the effectiveness of arteriovenous anastomosis (AVA) vs heated intravenous fluid (IVF) rewarming in hypothermic subjects. Additionally, we sought to develop a novel method of hypothermia induction.

    Methods: Eight subjects underwent 3 cooling trials each to a mean core temperature of 34. Read More

    Endovascular rewarming in the emergency department for moderate to severe accidental hypothermia.
    Am J Emerg Med 2017 May 8. Epub 2017 May 8.
    Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Avenue South, Minneapolis, MN, 55415, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hennepin County Medical Center, 701 Park Avenue South, Minneapolis, MN, 55415, USA.
    Background: Endovascular temperature control catheters can be utilized for emergent rewarming in accidental hypothermia. The purpose of this study was to compare patients with moderate to severe hypothermia rewarmed with an endovascular temperature control catheter versus usual care at our institution.

    Methods: We conducted a retrospective, observational cohort study of patients with moderate to severe accidental hypothermia (core body temperature less than 32°C) in the Emergency Department of an urban, tertiary care medical center. Read More

    Impact of Postoperative Hypothermia on Outcomes in Coronary Artery Bypass Surgery Patients.
    J Cardiothorac Vasc Anesth 2017 Feb 4. Epub 2017 Feb 4.
    Department of Cardiovascular and Thoracic Surgery, Hofstra Northwell School of Medicine, Manhasset, NY.
    Objectives: To determine the impact of postoperative hypothermia on outcomes in coronary artery bypass graft surgery (CABG) patients.

    Design: A retrospective study was performed on patients who underwent isolated CABG between 2011 and 2014.

    Setting: Single-center study at a university hospital. Read More

    How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?
    J Cereb Blood Flow Metab 2017 Jan 1:271678X17707671. Epub 2017 Jan 1.
    Department of Physiology, The University of Auckland, Auckland, New Zealand.
    The optimal duration of mild "therapeutic" hypothermia for neonates with hypoxic-ischemic encephalopathy is surprisingly unclear. This study assessed the relative efficacy of cooling for 48 h versus 72 h. Fetal sheep (0. Read More

    An Analysis of the Temperature Change in Warmed Intravenous Fluids During Administration in Cold Environments.
    Air Med J 2017 May - Jun;36(3):127-130. Epub 2017 Mar 11.
    Central Michigan University College of Medicine, Saginaw, MI.
    This nonhuman simulation study was conducted to determine the decrease in temperature that occurred to 1-L bags of normal saline in a cold environment. The bags were warmed to 39°C and administered through intravenous (IV) tubing at a set flow rate while in a cold environment. The goal was to determine if there was a significant decrease in fluid temperature from the bag to the catheter site. Read More

    [Retrograde Type A Aortic Dissection after Thoracic Endovascular Aortic Repair;Report of a Case].
    Kyobu Geka 2017 May;70(5):369-372
    Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, Tsukuba, Japan.
    A 72-year-old man presented with aneurysms of the distal aortic arch and the distal descending aorta due to chronic type B aortic dissection. We first performed thoracic endovascular aortic repair (TEVAR) in the distal descending aorta, and the aneurysm was successfully excluded using a Gore Tag stentgraft. Seven days after TEVAR, computed tomography revealed retrograde type A aortic dissection occurring from the ascending aorta to the distal aortic arch. Read More

    Deep and profound hypothermia in haemorrhagic shock, friend or foe? A systematic review.
    J R Army Med Corps 2017 May 11. Epub 2017 May 11.
    University of Leicester Medical School, Centre for Medicine, Leicester, UK.
    Introduction: Survival in exsanguinating cardiac arrest patients is poor, as is neurological outcome in survivors. Hypothermia has traditionally been seen as harmful to trauma patients and associated with increased mortality; however, there has been speculation that cooling to very low temperatures (≤20°C) could be used to treat haemorrhagic trauma patients by the induction of a suspended animation period through extreme cooling, which improves survival and preserves neurological function. This has been termed emergency preservation and resuscitation (EPR). Read More

    In Response to "Hypothermia for Neuroprotection in Convulsive Status Epilepticus".
    J Emerg Med 2017 May 8. Epub 2017 May 8.
    INSERM U970 (Team 4), Paris Cardiovascular Research Center, Paris, France; Medical Intensive Care Unit, Cochin University Hospital, Hopitaux Universitaires-Paris Centre, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité-Medical School, Paris, France.

    Trends in Management and Mortality in Adults Hospitalized With Cardiac Arrest in the United States.
    J Intensive Care Med 2017 Jan 1:885066617707921. Epub 2017 Jan 1.
    3 Division of Cardiology, Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY, USA.
    Background: We sought to examine temporal trends in management (ie, use of extracorporeal membrane oxygenation [ECMO], therapeutic hypothermia [TH], coronary angiogram, and percutaneous coronary intervention [PCI]) and in-hospital mortality in adults hospitalized with cardiac arrest.

    Methods: Utilizing the Nationwide Inpatient Sample, medical history, clinical management, and in-hospital mortality were assessed in 942 495 hospitalizations in adults with cardiac arrest (identified through International Classification of Diseases-9 codes) from 2006 to 2012.

    Results: From 2006 to 2012, there was an overall rise in the use of coronary angiogram (12. Read More

    Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition.
    Basic Res Cardiol 2017 Jul 10;112(4):35. Epub 2017 May 10.
    Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Réanimation Médicale, 5 Place d'Arsonval, 69437, Lyon Cedex 03, France.
    The opening of the mitochondrial permeability transition pore (PTP), which is regulated by the matrix protein cyclophilin D (CypD), plays a key role in the pathophysiology of post-cardiac arrest (CA) syndrome. We hypothesized that therapeutic hypothermia could prevent post-CA syndrome through a CypD-mediated PTP inhibition in both heart and brain. In addition, we investigated whether specific pharmacological PTP inhibition would confer additive protection to cooling. Read More

    [Effect of acupuncture combined with hypothermia on MAPK/ERK pathway and apoptosis related factors in rats with cerebral ischemia reperfusion injury].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Apr;42(4):380-388
    School of Acupuncture-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha 410208, China.
    Objective: To observe effect of acupuncture combined with hypothermia therapy on MAPK/ERK pathway and apoptosis related factorsin rats suffered cerebral ischemia reperfusion and to explore underlying mechanisms.
 Methods: Middle cerebral artery ischemia model were established.Ninety SD rats were randomly assigned into a blank group, a control group, a model group, an acupuncture group, a mild hypothermia group, and an acupuncture with hypothermia group. Read More

    Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
    Neurology 2017 May 10. Epub 2017 May 10.
    From the Departments of Neurology, Anesthesiology-Critical Care Medicine, and Neurosurgery (R.G.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (E.W., A.R.), Mayo Clinic, Rochester, MN; Department of Neurology (M.J.A.), University of Florida-McKnight Brain Institute, Gainesville; Department of Neurology and Neurocritical Care Unit (M.D.), Cambridge University Hospitals; The Ipswich Hospital (M.D.), Cambridge, UK; Departments of Neurology and Neurosurgery (S.A.M.), Mount Sinai-Icahn School of Medicine, New York, NY; Departments of Emergency Medicine and Internal Medicine (Cardiology) (J.P.O.), Virginia Commonwealth University College of Medicine, Richmond; Department of Neurology (J.I.S.), Baylor College of Medicine, Houston, TX; Department of Neurology and Neurosurgery (M.T.T.), Ohio State University, Columbus; Department of Neurology (R.M.D.), Kansas University Medical Center, Kansas City; and Department of Neurology (J.L.), University of Toronto, Canada.
    Objective: To assess the evidence and make evidence-based recommendations for acute interventions to reduce brain injury in adult patients who are comatose after successful cardiopulmonary resuscitation.

    Methods: Published literature from 1966 to August 29, 2016, was reviewed with evidence-based classification of relevant articles.

    Results And Recommendations: For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation (VF) after out-of-hospital cardiac arrest (OHCA), therapeutic hypothermia (TH; 32-34°C for 24 hours) is highly likely to be effective in improving functional neurologic outcome and survival compared with non-TH and should be offered (Level A). Read More

    A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score.
    Scand J Trauma Resusc Emerg Med 2017 May 10;25(1):49. Epub 2017 May 10.
    Department of Biostatistics, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Syowa-ku, Nagoya, Aichi, 4668560, Japan.
    Background: The aim of this study was to develop a scoring system for identifying the post-cardiac arrest syndrome (PCAS) patients with a good potential for recovery prior to the initiation of induced therapeutic hypothermia.

    Methods: A multi-center, retrospective, observational study was performed. Data of a total of 151 consecutive adults who underwent induced hypothermia after cardiac arrest (77 learning cases from two hospitals and 74 validation cases from two other hospitals) were analyzed. Read More

    Cord Blood IL-16 Is Associated with 3-Year Neurodevelopmental Outcomes in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy.
    Dev Neurosci 2017 May 11. Epub 2017 May 11.
    The Irish Centre for Foetal and Neonatal Translational Research (INFANT), Cork, Ireland.
    Activation of the inflammatory pathway is increasingly recognized as an important mechanism of injury following neonatal asphyxia and encephalopathy. This process may contribute to the poor prognosis seen in some cases, despite therapeutic hypothermia. Our group has previously identified raised interleukin (IL)-6 and IL-16, measured in umbilical cord blood at birth, to be predictive of grade of hypoxic-ischaemic encephalopathy (HIE). Read More

    Endovascular pulmonary artery inflatable balloon-induced hypotension: A novel technique for clipping giant intracranial aneurysms.
    Neurol India 2017 May-Jun;65(3):566-569
    Institutes of Neurosciences, SIMS Hospitals, Chennai, Tamil Nadu, India.
    Management of giant intracranial aneurysms presents unique challenges to the neurosurgical team. Various techniques such as adenosine-induced hypotension, rapid ventricular pacing, and inducing deep hypothermia are described in the literature to effect circulatory arrest for the successful obliteration of giant aneurysms. We describe a novel technique of induced hypotension for clipping a giant aneurysm by using an inflatable balloon across the main pulmonary artery with a successful outcome. Read More

    Pediatric Drowning: A Standard Operating Procedure to Aid the Prehospital Management of Pediatric Cardiac Arrest Resulting From Submersion.
    Pediatr Emerg Care 2017 May 8. Epub 2017 May 8.
    From the *Cardiff University School of Medicine; †Institute of Medicine Education, Cardiff, Wales; ‡St Anne's College, University of Oxford, Oxford, England; §Department of Cardiology, St George's Hospital, Tooting, London; and ∥Emergency Medical Retrieval and Transfer Service, Llanelli, Wales, United Kingdom.
    Objectives: Drowning is one of the leading causes of death in children. Resuscitating a child following submersion is a high-pressure situation, and standard operating procedures can reduce error. Currently, the Resuscitation Council UK guidance does not include a standard operating procedure on pediatric drowning. Read More

    Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy.
    Dev Neurosci 2017 May 10. Epub 2017 May 10.
    Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA.
    Background: Cerebral palsy (CP) is the most common motor disability in childhood, with a worldwide prevalence of 1.5-4/1,000 live births. Hypoxic-ischemic encephalopathy (HIE) contributes to the burden of CP, but the long-term neuropathological findings of this association remain limited. Read More

    The clinical study on the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia.
    Eur Rev Med Pharmacol Sci 2017 04;21(8):1999-2006
    Qingdao University, Shandong, China.
    Objective: This study was purposed to evaluate the clinical efficacy of the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia.

    Patients And Methods: Thirty patients, diagnosed with acute anterior circulation cerebral infarction and admitted to the Hospital between January 2013 and September 2015, were randomly divided into the control group and the mild hypothermia group, each group comprising 15 cases. The treatment of intra-arterial thrombolysis combined with mild hypothermia was administered to the mild hypothermia group, while only the treatment of intra-arterial thrombolysis was performed on the control group. Read More

    Ischemic Preconditioning in the Intensive Care Unit.
    Curr Treat Options Neurol 2017 Jun;19(6):24
    Department of Neurology, University of Miami, Miller School of Medicine, 1120 NW 14th Street, CRB 1365, Miami, FL, 33136, USA.
    Opinion Statement: Preconditioning is the premise that controlled preemptive exposure to sub-lethal doses of a stressor and can condition an organism or organ to later withstand a lethal dose. This process relies on marshaling endogenous survival resources that have evolved as part of an organism's evolutionary struggle to overcome at times harsh environmental conditions. This preconditioning response occurs through activation of myriad complex mechanisms that run the gamut from alterations in gene expression to the de novo synthesis and post-translational modification of proteins, and it may occur across exposure to a wide variety of stressors (i. Read More

    1 OF 832