44,134 results match your criteria Hypothermia


Predicting survival in out-of-hospital cardiac arrest patients undergoing targeted temperature management: The Polish Hypothermia Registry Risk Score.

Cardiol J 2019 Apr 17. Epub 2019 Apr 17.

Intensive Cardiac Therapy Clinic, Institute of Cardiology Warsaw, Poland.

Background: Prompt reperfusion and post-resuscitation care, including targeted temperature management (TTM), improve survival in out-of-hospital cardiac arrest (OHCA) patients. To predict in-hospital mortality in OHCA patients treated with TTM, the Polish Hypothermia Registry Risk Score (PHR-RS) was developed. The use of dedicated risk stratification tools may support treatment decisions. Read More

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https://journals.viamedica.pl/cardiology_journal/article/vie
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http://dx.doi.org/10.5603/CJ.a2019.0035DOI Listing
April 2019
1 Read

Impact of adrenaline dose and timing on out-of-hospital cardiac arrest survival and neurological outcomes.

Resuscitation 2019 Apr 13. Epub 2019 Apr 13.

Center for Resuscitation Science and the Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Study Objective: The 2015 ILCOR Advanced Cardiovascular Life Support Guidelines recommend intravenous adrenaline (epinephrine) as a crucial pharmacologic treatment during cardiac arrest resuscitation. Some recent observational studies and clinical trials have questioned the efficacy of its use and suggested possible deleterious effects on overall survival and long-term outcomes. This study aimed to describe the association between time and dose of adrenaline on return of spontaneous circulation (ROSC) and neurologic function. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.018DOI Listing

Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function.

Life Sci 2019 Apr 13. Epub 2019 Apr 13.

HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.

Aims: The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model.

Main Methods: Rats were randomized to normothermia (n = 10) or LTH (initiated at 1 min after coronary artery reperfusion, n = 10) and subjected to 30 min of coronary occlusion followed by 6 weeks of reperfusion. Hypothermia was induced by pumping cold saline over the anterior surface of the LV until the temperature cooled to <32 °C. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.026DOI Listing

Maternal consumption of piceatannol: a nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

CRMSB, UMR 5536, CNRS/University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address:

Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1,000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.012DOI Listing

Influence of oral premedication and prewarming on core temperature of cardiac surgical patients: a prospective, randomized, controlled trial.

BMC Anesthesiol 2019 Apr 12;19(1):55. Epub 2019 Apr 12.

Department of Anaesthesiology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Background: Perioperative hypothermia is still very common and associated with numerous adverse effects. The effects of benzodiazepines, administered as premedication, on thermoregulation have been studied with conflicting results. We investigated the hypotheses that premedication with flunitrazepam would lower the preoperative core temperature and that prewarming could attenuate this effect. Read More

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https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12871-019-0725-7DOI Listing
April 2019
1 Read

The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.

Shock 2019 May;51(5):667-673

Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, Virginia.

Neurotensin is an endogenous tridecapeptide that binds to neurotensin receptors in the brain, which induce hypothermia. The aim of this study was to investigate whether the receptor agonist ABS 201 could induce therapeutic hypothermia and improve postresuscitation outcomes in a ventricular fibrillation cardiac arrest (VFCA) rat model. VF was electrically induced in 12 rats. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001178DOI Listing

Acylcarnitine profile in neonatal hypoxic-ischemic encephalopathy: The value of butyrylcarnitine as a prognostic marker.

Medicine (Baltimore) 2019 Apr;98(15):e15221

Neonatal Unit, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela.

Optimal prognostic markers evaluating early neuroprotective interventions in neonatal hypoxic-ischemic encephalopathy (HIE) are lacking. This study was designed to assess the prognostic value of acylcarnitines in neonatal HIE.An observational cohort study was conducted over 10 years in 67 HIE. Read More

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http://dx.doi.org/10.1097/MD.0000000000015221DOI Listing

Efficacy of forced-air warming and warmed intravenous fluid for prevention of hypothermia and shivering during caesarean delivery under spinal anaesthesia: A randomised controlled trial.

Eur J Anaesthesiol 2019 Apr 5. Epub 2019 Apr 5.

From the Department of Anaesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.

Background: Peri-operative hypothermia and shivering are frequent events in patients during caesarean delivery under spinal anaesthesia.

Objective: We assessed the efficacy of combined pre-anaesthetic forced-air warming in combination with warmed intravenous fluid infusion for preventing hypothermia and shivering during caesarean delivery under spinal anaesthesia.

Design: A randomised controlled study. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000990DOI Listing

Management of Major Burns in 37 Casualties of a Colored Powder Explosion: Experience of the Linkou Burn Center in Taiwan.

Ann Plast Surg 2019 May;82(5):512-519

From the Department of Plastic and Reconstructive Surgery, and.

Background: On June 27, 2015, a colored powder explosion occurred in Taiwan. As a result, 499 people were injured, and over 200 people were in critical condition because of severe burns. Forty-nine casualties were transported to the Chang Gung Memorial Hospital. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001928DOI Listing
May 2019
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Shoshin Beriberi and Severe Accidental Hypothermia as Causes of Heart Failure in a 6-Year-Old Child: A Case Report and Brief Review of Literature.

Front Pediatr 2019 29;7:119. Epub 2019 Mar 29.

Pediatric Intensive Care Department, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium.

Severe accidental hypothermia has been demonstrated to affect ventricular systolic and diastolic functions, and rewarming might be responsible of cardiovascular collapse. Until now, there have been only a few reports on severe accidental hypothermia, none of which involved children. Herein, we describe here a rare case of heart failure in a 6-year-old boy admitted to the emergency unit owing to severe hypothermia and malnutrition. Read More

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http://dx.doi.org/10.3389/fped.2019.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449648PMC

Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): inhibition of succinate-fueled respiration and K transport, ROS-induced activation of mitochondrial permeability transition.

J Bioenerg Biomembr 2019 Apr 13. Epub 2019 Apr 13.

Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.

The article considers the comparative analysis of the functional activity of mitochondria isolated from the liver of grass snakes, Natrix natrix (Linnaeus, 1758) that were kept at different temperatures (23-26 °C and 4-5 °C). It was found that liver mitochondria of hypothermia-exposed grass snakes are characterized by weak coupling of oxidative phosphorylation as compared to mitochondria of active animals which is caused by inhibition of succinate-fuelled respiration in ADP-stimulated state, as well as by activation of basal non-phosphorylating rate. Inhibition of mitochondrial respiration in hibernating animals is associated with a decrease in the activity of the respiratory chain complexes of organelles. Read More

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http://dx.doi.org/10.1007/s10863-019-09796-6DOI Listing

Vein "Beltization" Technique Facilitates Venous Anastomoses for Laparoscopic Orthotopic Kidney Transplantation in a Pig Model.

Transplant Proc 2019 Apr 9;51(3):913-918. Epub 2019 Jan 9.

Liver and Kidney Transplant Service, Sir Charles Gairdner Hospital, School of Surgery, The University of Western Australia, Nedlands, Perth, Australia.

Objective: This study was performed to investigate the safety and efficiency of the renal vein "beltization" technique for laparoscopic orthotopic kidney transplantation (LOKT) in a pig model.

Material And Methods: Kidney autotransplants were conducted, in which the renal vein beltization technique was employed, in 12 domestic pigs. In the operation, the right kidney was autotransplanted to the left kidney vessel trunks. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.034DOI Listing

Does low body fat percentage in neonates greater than the 5th percentile birthweight increase the risk of hypoglycaemia and neonatal morbidity?

J Paediatr Child Health 2019 Apr 11. Epub 2019 Apr 11.

Neonatal Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Aim: Low body fat percentage (BF%) has been shown to predict morbidity and possible hypoglycaemia in newborns. Hypoglycaemia in neonates is associated with significant neonatal morbidity. Early detection and prevention are critical. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.14433
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http://dx.doi.org/10.1111/jpc.14433DOI Listing
April 2019
4 Reads

Normal Body Temperature: A Systematic Review.

Open Forum Infect Dis 2019 Apr 9;6(4):ofz032. Epub 2019 Apr 9.

Icahn School of Medicine at Mount Sinai, New York, NY.

PubMed was searched from 1935 to December 2017 with a variety of search phrases among article titles. The references of the identified manuscripts were then manually searched. The inclusion criteria were as follows: (1) the paper presented data on measured normal body temperature of healthy human subjects ages 18 and older, (2) a prospective design was used, and (3) the paper was written in or translated into the English language. Read More

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http://dx.doi.org/10.1093/ofid/ofz032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456186PMC
April 2019
1 Read

Takotsubo cardiomyopathy developed during rewarming of accidental hypothermia with extracorporeal membrane oxygenation.

Acute Med Surg 2019 Apr 1;6(2):201-205. Epub 2019 Mar 1.

Department of Emergency Medicine Sapporo Medical University Hokkaido Japan.

Background: We here present the first case report of takotsubo cardiomyopathy that developed during rewarming of a patient with severe accidental hypothermia with extracorporeal membrane oxygenation.

Case: A 74-year-old woman was found unresponsive outdoors and suffered cardiopulmonary arrest during transfer to our hospital. On arrival, she was still in cardiopulmonary arrest. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ams2.399
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http://dx.doi.org/10.1002/ams2.399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442525PMC
April 2019
2 Reads

Investigation of Frequency of the Lethal Triad and Its 24 Hours Prognostic Value among Patients with Multiple Traumas.

Open Access Maced J Med Sci 2019 Mar 26;7(6):962-966. Epub 2019 Mar 26.

Department of Emergency Medicine, Orthopedic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Death in multiple trauma (MT) patients is one of the serious concerns of the medical service provider. Any prediction of the likelihood of death on the assessment of the patient's condition is performed using different variables, one of the tools in the triage of patients to determine their condition.

Aim: We aimed to investigate the frequency and the predictive value of death in 24 hours triad of death in patients qualified with multiple traumas admitted to Imam Khomeini hospital. Read More

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http://dx.doi.org/10.3889/oamjms.2019.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454176PMC
March 2019
1 Read

A Prospective Clinical Trial Measuring the Effects of Cardiopulmonary Bypass Under Mild Hypothermia on the Inflammatory Response and Regulation of Cold-Shock Protein RNA-Binding Motif 3.

Ther Hypothermia Temp Manag 2019 Apr 11. Epub 2019 Apr 11.

1 Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Institute Berlin, Berlin, Germany.

Therapeutic hypothermia during cardiac surgery has been widely used for neuroprotection and to attenuate the systemic inflammatory response due to cardiopulmonary bypass (CPB). Experimental data suggest that cold-shock protein RNA-binding motif 3 (RBM3), which is induced in response to hypothermia, plays a key role in hypothermia-induced organ protection. To date, investigation on RBM3 has been performed exclusively in vitro or in animal models, and the detection and regulation of RBM3 in human blood has not been investigated until now. Read More

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http://dx.doi.org/10.1089/ther.2018.0038DOI Listing
April 2019
1 Read

Correction to: Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

Basic Res Cardiol 2019 04 9;114(3):24. Epub 2019 Apr 9.

Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.

The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00395-019-0731-4DOI Listing
April 2019
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A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn.

Front Pediatr 2019 22;7:95. Epub 2019 Mar 22.

Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey.

Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coagulation. Herein, we report a case of a newborn who had meconium aspiration syndrome and HIE and underwent both TH and ECMO. Read More

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http://dx.doi.org/10.3389/fped.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439343PMC
March 2019
1 Read

Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury.

Front Physiol 2019 22;10:283. Epub 2019 Mar 22.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Read More

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http://dx.doi.org/10.3389/fphys.2019.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440382PMC
March 2019
1 Read

Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats.

Nutr Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Anesthesiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan.

The intravenous administration of an amino acid (AA) mixture during general anesthesia reduces anesthesia-induced hypothermia. AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.02.007DOI Listing
March 2019
1 Read

Effect of forced-air warming by an underbody blanket on end-of-surgery hypothermia: a propensity score-matched analysis of 5063 patients.

BMC Anesthesiol 2019 Apr 9;19(1):50. Epub 2019 Apr 9.

Department of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Background: Underbody blankets have recently been launched and are used by anesthesiologists for surgical patients. However, the forced-air warming effect of underbody blankets is still controversial. The aim of this study was to determine the effect of forced-air warming by an underbody blanket on body temperature in anesthetized patients. Read More

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http://dx.doi.org/10.1186/s12871-019-0724-8DOI Listing
April 2019
1 Read

Management of accidental hypothermia: an established extracorporeal membrane oxygenation centre experience.

Perfusion 2019 Apr;34(1_suppl):74-81

5 2nd Department of Internal Medicine - Department of Cardiovascular Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Introduction: Data on management of severe accidental hypothermia published from an established high-volume extracorporeal membrane oxygenation centre are scarce.

Methods: A total of 28 patients with intravesical temperature lower than 28°C on admission were either treated with veno-arterial extracorporeal membrane oxygenation or rewarmed conservatively.

Results: A total of 10 patients rewarmed on veno-arterial extracorporeal membrane oxygenation (age: 37 ± 12. Read More

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http://dx.doi.org/10.1177/0267659119830551DOI Listing
April 2019
1 Read

Voluntary oral consumption of Δ-tetrahydrocannabinol by adolescent rats impairs reward-predictive cue behaviors in adulthood.

Neuropsychopharmacology 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

Few preclinical approaches are available to study the health impact of voluntary consumption of edibles containing the psychoactive drug Δ-tetrahydrocannabinol (THC). We developed and validated such approach by measuring voluntary oral consumption of THC-containing gelatin by rats and used it to study if and how THC consumption during adolescence impacts adult behavior. We found that adolescent rats of both sexes consumed enough THC to trigger acute hypothermia, analgesic, and locomotor responses, and that 15 days of access to THC-gelatin in adolescence resulted in the down-regulation of cannabinoid 1 receptors (CBRs) in adulthood in a sex and brain area specific manner. Read More

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http://dx.doi.org/10.1038/s41386-019-0387-7DOI Listing
April 2019
1 Read

Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats.

Neuropharmacology 2019 Apr 6. Epub 2019 Apr 6.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address:

The current opioid overdose crisis is being exacerbated by illicitly manufactured fentanyl and its analogs. Carfentanil is a fentanyl analog that is 10,000-times more potent than morphine, but limited information is available about its pharmacology. The present study had two aims: 1) to validate a method for quantifying carfentanil and its metabolite norcarfentanil in small-volume samples, and 2) to use the method for examining pharmacodynamic-pharmacokinetic relationships in rats. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.002DOI Listing
April 2019
3 Reads

Current practices in deceased organ donor management.

Curr Opin Organ Transplant 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Division of Transplant, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies.

Recent Findings: Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000638DOI Listing
April 2019
2 Reads

"Cold and lonely". Emergency presentations of patients with hypothermia to a large Australian health network.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

General Medical Unit, Alfred Health, Melbourne, Victoria, Australia.

Background: Extreme heat is a public health priority in Australia with the health effects of cold poorly studied. A record-breaking cold winter prompted an institutional investigation into the epidemiology and outcomes of hypothermic presentations.

Method: This was a retrospective cohort observational study of hypothermic emergency presentations between 7 July 2009 and 1 September 2016 with a temperature of ≤35°C. Read More

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http://dx.doi.org/10.1111/imj.14308DOI Listing
April 2019
1 Read

Correction: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.

J Perinatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

A correction to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41372-019-0371-4DOI Listing
April 2019
1 Read

Hybrid treatment of an unusual traumatic aortic arch rupture with pseudoaneurysm: a case report.

J Cardiothorac Surg 2019 Apr 8;14(1):68. Epub 2019 Apr 8.

Cardiovascular Center, Suining Central Hospital, No.127, West Desheng Road, Chuanshan District, Suining, 629000, Sichuan, China.

Background: Traumatic aortic arch rupture with pseudoaneurysm is a rare high fatal injury. Thoracic endovascular aortic repair(TEVAR) is widely used in the treatment of aortic diseases. However a unified traumatic aortic injury risk stratification tool still lacks. Read More

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http://dx.doi.org/10.1186/s13019-019-0896-9DOI Listing
April 2019
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Hypothermia Masks Most of the Effects of Rapid Cycling VNS on Rat Hippocampal Electrophysiology.

Int J Neural Syst 2019 Feb 14:1950008. Epub 2019 Feb 14.

1 Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University, Corneel Heymanslaan 10 Ghent, Flanders, Belgium.

Aim: Vagus nerve stimulation (VNS) modulates hippocampal dentate gyrus (DG) electrophysiology and induces hypothermia in freely moving rats. This study evaluated whether hippocampal (CA1) electrophysiology is similarly modulated and to what extent this is associated with VNS-induced hypothermia.

Methods: Six freely moving rats received a first 4 h session of rapid cycling VNS (7 s on/18 s off), while CA1 evoked potentials, EEG and core temperature were recorded. Read More

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http://dx.doi.org/10.1142/S0129065719500084DOI Listing
February 2019
2 Reads

Assessment of Fed-batch Cultivation Strategies for an Inducible CHO Cell Line.

J Biotechnol 2019 Apr 5. Epub 2019 Apr 5.

Department of Chemical Engineering, École Polytechnique de Montréal, P.O. Box 6079, succ. Centre-Ville, Montréal QC, H3C 3A7, Canada. Electronic address:

In order to maximize cell growth and productivity for an inducible CHO cell line expressing rituximab, various fed-batch culture strategies were investigated. In each case, the performance was evaluated for cultures induced at moderate and high cell density conditions (4 × 10 and 10 × 10 cells/mL) to assess the impact of the timing of induction. We first demonstrate the importance of starting the feeding process during the growth phase, as this translated into significantly improved integral of viable cells and antibody concentration, when compared to post-induction feeding only. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.04.005DOI Listing
April 2019
3 Reads

A new low-cost commercial bubble CPAP (bCPAP) machine compared with a traditional bCPAP device in Nigeria.

Paediatr Int Child Health 2019 Apr 8:1-9. Epub 2019 Apr 8.

e Department of Paediatrics , Federal Medical Centre , Jabi , Nigeria.

Background: The bubble continuous positive airway pressure (bCPAP) technique is widely applied in neonatal respiratory support. Commercial bCPAP brands are expensive in Nigeria and this has driven Nigerian paediatricians to use potentially risky improvised devices (IbCPAP).

Aim: This study aimed to design, produce and trial an appropriate low-cost bCPAP machine which is functionally effective and safe. Read More

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http://dx.doi.org/10.1080/20469047.2019.1598125DOI Listing
April 2019
1 Read

The role of mitochondrial and endoplasmic reticulum ROS production in models of perinatal brain injury.

Antioxid Redox Signal 2019 Apr 8. Epub 2019 Apr 8.

University of Gothenburg, 3570, Centre of Perinatal Medicine and Health, Sahlgrenska Academy, Gothenburg, Sweden.

Significance: Perinatal brain injury is caused by hypoxia-ischemia (HI) in term neonates, perinatal arterial stroke, and infection/inflammation leading to devastating long-term neurodevelopmental deficits. Therapeutic hypothermia is the only currently available treatment but is not successful in more than 50% of term neonates suffering from hypoxic-ischemic encephalopathy. Thus, there is an urgent unmet need for alternative or adjunct therapies. Read More

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http://dx.doi.org/10.1089/ars.2019.7779DOI Listing
April 2019
1 Read

Mild hypothermia is associated with improved outcomes in patients undergoing microvascular head and neck reconstruction.

Am J Otolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Objective: Microvascular free tissue transfer has become the standard for reconstruction for large defects. With long operative times and an increased surface area exposed, transient hypothermia is common, but it is unclear how this impacts surgical outcomes. This study evaluated the impact of core body temperature on free tissue flap outcomes in patients undergoing microvascular reconstruction. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.010DOI Listing

Grey-white matter ratio measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest.

Resuscitation 2019 Apr 3. Epub 2019 Apr 3.

Department of Emergency Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address:

Aim: This study evaluated whether the grey-white matter ratio (GWR) assessed via early brain computed tomography (CT) within 2 h after the return of spontaneous circulation (ROSC) following cardiac arrest is associated with poor neurological outcomes after 6 months in post-cardiac arrest patients treated with targeted temperature management (TTM).

Methods: This study used data from the Korean Hypothermia Network prospective registry obtained from November 2015 to October 2017 to assess patients with out-of-hospital cardiac arrest (OHCA) who underwent brain CT within 2 h following the ROSC. The primary endpoint was the neurological outcome 6 months post-cardiac arrest (cerebral performance category; CPC). Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.039DOI Listing
April 2019
2 Reads

Resistance towards nondepolarising muscle relaxants: prolonged onset time: A systematic review.

Eur J Anaesthesiol 2019 Apr 3. Epub 2019 Apr 3.

From the Department of Anaesthesiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark (EL-M, ML-K, JB-S, CM-S, MV-M, MR-G).

Background: Nondepolarising muscle relaxants (NDMRs) provide optimal conditions for tracheal intubation and improve surgical conditions. Several clinical conditions, diseases and pharmacological interactions have been suggested to cause resistance towards NDMRs that may translate into difficult intubation or inadequate operating conditions during surgery.

Objective: The aim of this study was to evaluate the current evidence of patient groups with resistance towards NDMRs. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000991DOI Listing
April 2019
2 Reads
3.011 Impact Factor

Predictors of hypothermia upon trauma centre arrival in severe trauma patients transported to hospital via EMS.

Prehosp Emerg Care 2019 Apr 4:1-10. Epub 2019 Apr 4.

a Division of Emergency Medicine, Department of Medicine , Western University , London , Canada.

Introduction: Hypothermia in severe trauma patients can increase mortality by 25%. Active warming practices decrease mortality and are recommended in the Advanced Trauma Life Support (ATLS) guidelines. Despite this, many emergency medical services (EMS) vehicles do not carry equipment necessary to perform active warming. Read More

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http://dx.doi.org/10.1080/10903127.2019.1599474DOI Listing
April 2019
2 Reads

Current status of robotic kidney transplant and its future.

Arch Esp Urol 2019 04;72(3):336-346

Department of Urology. Fundació Puigvert. Autonomous University of Barcelona. Barcelona. Spain.

Objectives: Open kidney transplantation (OKT) represents the standard approach in patients with end-stage renal disease, but recently robotic-assisted kidney transplantation (RAKT) has also become an accepted approach.

Methods: We conducted a systematic review using the PubMed/Medline and Embase databases and the keywords "Robotic kidney transplantation" and "Robotic-assisted kidney transplantation".

Results: Past studies of RAKT have tended to suffer from patient selection bias, but, following completion of the learning curves in specialized centers, the indications for RAKT have recently been expanded to include more complex cases. Read More

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April 2019
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Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury.

Front Physiol 2019 19;10:282. Epub 2019 Mar 19.

Perinatal Brain Protection and Repair Group, EGA Institute for Women's Health, University College London, London, United Kingdom.

Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Read More

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http://dx.doi.org/10.3389/fphys.2019.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433879PMC
March 2019
5 Reads

Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score.

Resuscitation 2019 Mar 30. Epub 2019 Mar 30.

Emergency Department, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Aims: The HOPE score, based on covariates available at hospital admission, predicts the probability of in-hospital survival after extracorporeal life support (ECLS) rewarming of a given hypothermic cardiac arrest patient with accidental hypothermia. Our goal was to externally validate the HOPE score.

Methods: We included consecutive hypothermic arrested patients who underwent rewarming with ECLS. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.017DOI Listing
March 2019
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Hypothermia during umbilical catheterization in preterm infants.

J Matern Fetal Neonatal Med 2019 Apr 2:1-6. Epub 2019 Apr 2.

a Department of Pediatrics, Division of Neonatology , Leiden University Medical Center , Leiden , the Netherlands.

Objective: To describe the effect of umbilical catheterization (UC) on skin temperature and cardiorespiratory status in preterm infants.

Materials And Methods: In a prospective observational study of infants <32 weeks of gestation, the duration of UC, course of skin temperature, and cardiorespiratory status were registered. Hypothermia was defined as a temperature below 36. Read More

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http://dx.doi.org/10.1080/14767058.2019.1598365DOI Listing
April 2019
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[Risk factors of surgical treatment of acute aortic dissection type A (in Russian only)].

Khirurgiia (Mosk) 2019 (3):15-20

Pirogov Russian National Research Medical University, Moscow, Russia.

Aim: To evaluate risk factors of surgical treatment of acute aortic dissection type A.

Material And Methods: Retrospective analysis included 100 patients with acute aortic dissection type A who underwent surgery in 2007-2017. Patients were divided into 2 groups: group I (survivors, n=79) and group II (unfavorable outcomes, n=21). Read More

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http://dx.doi.org/10.17116/hirurgia201903115DOI Listing
January 2019

Temperature Dependence of Erythrocytic Stage Development.

Am J Trop Med Hyg 2019 Apr 1. Epub 2019 Apr 1.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

infection causes febrile illness and severe disease with multiple organ failure and death when treatment is delayed. Antipyretic treatment is standard, and inducing hypothermia has been proposed to protect the brain in cerebral malaria. Here, we investigated the temperature dependence of asexual-stage parasite development and parasite multiplication in vitro. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0894DOI Listing
April 2019
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Variability in the Drug Response of M Muscarinic Receptor Knockout Mice During Day and Night Time.

Front Pharmacol 2019 18;10:237. Epub 2019 Mar 18.

Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czechia.

Mice are nocturnal animals. Surprisingly, the majority of physiological/pharmacological studies are performed in the morning, i.e. Read More

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http://dx.doi.org/10.3389/fphar.2019.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431655PMC
March 2019
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Change in neuron specific enolase levels in out-of-hospital cardiopulmonary arrest survivors as a simple and useful tool to predict neurological prognosis.

Rev Esp Cardiol (Engl Ed) 2019 Mar 29. Epub 2019 Mar 29.

Unidad de Críticos Cardiovasculares, Departamento de Cardiología, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Centro de Investigación Biomédica En Red enfermedades Cardiovasculares (CIBERCV), Fundación Hospital Universitario Vall d'Hebron-Institut de Recerca (VHIR), Barcelona, Spain. Electronic address:

Introduction And Objectives: Neuron-specific enolase (NSE) is a prognostic marker in out-of-hospital cardiopulmonary arrest (OHCA) survivors treated with mild therapeutic hypothermia (MTH). The objectives were to analyze the correlation between dynamic changes in NSE and outcomes and to determine the measurement timing that best predicts neurological status.

Methods: Multicenter cohort study including patients admitted after shockable rhythm OHCA and treated with MTH. Read More

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http://dx.doi.org/10.1016/j.rec.2019.01.007DOI Listing
March 2019
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Butorphanol-Azaperone-Medetomidine for the Immobilization of Rhesus Macaques (Macaca mulatta).

J Am Assoc Lab Anim Sci 2019 Apr 1. Epub 2019 Apr 1.

Maximizing animal wellbeing by minimizing drug-related side effects is a key consideration when choosing pharmaceuticalagents for chemical restraint in nonhuman primates. One drug combination that may promote this ideology is butorphanol(27.3 mg/mL), azaperone (9. Read More

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http://dx.doi.org/10.30802/AALAS-JAALAS-18-000088DOI Listing
April 2019
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Conventional intensive versus LED intensive phototherapy oxidative stress burden in neonatal hyperbilirubinaemia of haemolytic origin.

Paediatr Int Child Health 2019 Apr 1:1-5. Epub 2019 Apr 1.

b Pediatric Department, Faculty of Medicine , Cairo University , Cairo , Egypt.

Background: Phototherapy causes oxidative stress which is of particular importance in neonates because of the increased susceptibility of neonatal red blood cell membranes to oxidative damage.

Aim: To evaluate the oxidant/antioxidant status in neonates with haemolytic hyperbilirubinaemia before and after exposure to two different intensive phototherapy light sources.

Patients And Methods: A randomised controlled study was undertaken in 54 full-term neonates with indirect haemolytic hyperbilirubinaemia admitted to a neonatal intensive care unit in the first week of life. Read More

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http://dx.doi.org/10.1080/20469047.2019.1586185DOI Listing
April 2019
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Study of the changes in respiratory function in self-contained underwater breathing apparatus divers.

Int Marit Health 2019 ;70(1):61-64

Military Medical Academy, Centre of Military Medical Expertise Aero and Maritime Medicine, Varna, Bulgaria.

Background: The objective was to investigate the respiratory function of professional divers by conducting spirometry and to compare the data obtained with those of non-divers.

Materials And Methods: This study involved 52 military divers who carried out dives at small and medium depths using a self-contained underwater breathing apparatus (SCUBA) with open-circuit regulators attached to a mouthpiece. The control group consisted of 48 persons from deck commands with similar physiological characteristics and lifestyle that were not divers and had never been under increased pressure. Read More

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http://dx.doi.org/10.5603/IMH.2019.0009DOI Listing
January 2019
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Vascularized Parenchymal Mass Preserved with Partial Nephrectomy: Functional Impact and Predictive Factors.

Eur Urol Oncol 2019 Feb 14;2(1):97-103. Epub 2018 Jul 14.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Percentage parenchymal mass preserved (PPMP) is a key determinant of functional outcomes after partial nephrectomy (PN); however, predictors of PPMP have not been defined.

Objective: To provide a comprehensive analysis of the functional impact of and potential predictive factors for PPMP.

Design, Setting, And Participants: We analyzed data for 464 patients managed with PN at our center with necessary studies to determine vascularized parenchymal mass and function preserved within the operated kidney. Read More

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http://dx.doi.org/10.1016/j.euo.2018.06.009DOI Listing
February 2019
2 Reads