43,711 results match your criteria Hypothermia


One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

Background: Limited data exist regarding neurobehavioral outcomes of children treated with open-chest cardiopulmonary resuscitation (CPR). Our objective was to describe neurobehavioral outcomes one year post-arrest among children who received open-chest CPR during in-hospital cardiac arrest; and explore factors associated with one-year survival and survival with good neurobehavioral outcome.

Methods: The study is a secondary analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital Trial. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.11.028DOI Listing
December 2018

The Transcriptional Signature of a Runner's High.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

SUNY Upstate Medical University, Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology, Pediatrics, and Psychiatry & Behavioral Sciences, Syracuse NY.

Introduction: Endorphins, endocannabinoids, monoamines, and neurotrophins have all been implicated in the euphoric response to endurance running, known as a runner's high. The epi-transcriptional mechanisms regulating this effect have not been defined. Here, we investigate peripheral micro-ribonucleic acid (miRNA) changes unique to athletes experiencing post-run euphoria, yielding insights about gene networks that control a runner's high. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001865DOI Listing
December 2018

Exploration of the optimal dose of HOE-642 for the protection of neuronal mitochondrial function after cardiac arrest in rats.

Biomed Pharmacother 2018 Dec 13;110:818-824. Epub 2018 Dec 13.

Department of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Electronic address:

Introduction: It has been demonstrated HOE-642 ameliorates ischemic contracture, prevents post-resuscitation diastolic dysfunction, and favors the earlier return of contractile function. This study is the first report to explore the optimal dose of HOE-642 in protecting the neuronal mitochondrial function after cardiac arrest.

Methods: Cardiac arrest was induced by 8 min asphyxia in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183789
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http://dx.doi.org/10.1016/j.biopha.2018.12.035DOI Listing
December 2018
1 Read

Mid-term clinical outcomes of out-of-hospital cardiac arrest patients treated with targeted temperature management at 34-36 °C versus 32-34 °C.

Heart Lung 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21, Prague, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: Targeted temperature management (TTM) in comatose survivors of out-of-hospital cardiac arrest has been associated with improved neurological outcomes. However, the optimal temperature target for TTM remains unclear.

Objectives: To compare a TTM protocol targeted at 34-36 °C with a protocol targeted at 32-34 °C with reference to both clinical outcomes and acute complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01479563183028
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http://dx.doi.org/10.1016/j.hrtlng.2018.11.007DOI Listing
December 2018
1 Read

A Pilot Study of Soluble Form of LOX-1 as a Novel Biomarker for Neonatal Hypoxic-Ischemic Encephalopathy.

J Pediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address:

Objective: To evaluate the soluble form of lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) as a biomarker of severity staging and prognosis in neonatal hypoxic-ischemic encephalopathy (HIE).

Study Design: We performed an observational study enrolling 27 infants with HIE and 45 control infants of gestational age ≥36 weeks and birth weight ≥1800 g. The HIE criteria were pH ≤7. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.10.036DOI Listing
December 2018

Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676052
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http://dx.doi.org/10.1055/s-0038-1676052DOI Listing
December 2018
2 Reads

A population-based study of cystic white matter injury on ultrasound in very preterm infants born over two decades in Nova Scotia, Canada.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada.

Objective: To identify the temporal trends, risk factors and outcomes of cystic white matter injury (WMI) detected by ultrasound in a population-based cohort of very preterm infants (VPI) with a minimal risk of selection bias.

Study Design: All live-born VPIs between 22 and < 31 weeks gestational age born in Nova Scotia, Canada from 1993 to 2013.

Results: Cystic WMI was identified in 87 (7%) out of 1184 eligible infants. Read More

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http://dx.doi.org/10.1038/s41372-018-0294-5DOI Listing
December 2018

Loss of adult 5-HT1A autoreceptors results in a paradoxical anxiogenic response to antidepressant treatment.

J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Ottawa Hospital Research Institute (Neuroscience), Ottawa, Canada

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants, but require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization of 5-HT1A autoreceptors to enhance 5-HT neurotransmission. Mice (both sexes) with gene deletion of 5-HT1A autoreceptors in adult 5-HT neurons (1AcKO) were tested for response to SSRIs. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0352-18.2018DOI Listing
December 2018

Postdischarge Mortality Prediction in Sub-Saharan Africa.

Pediatrics 2018 Dec 14. Epub 2018 Dec 14.

Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique;

Background: Although the burden of postdischarge mortality (PDM) in low-income settings appears to be significant, no clear recommendations have been proposed in relation to follow-up care after hospitalization. We aimed to determine the burden of pediatric PDM and develop predictive models to identify children who are at risk for dying after discharge.

Methods: Deaths after hospital discharge among children aged <15 years in the last 17 years were reviewed in an area under demographic and morbidity surveillance in Southern Mozambique. Read More

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http://dx.doi.org/10.1542/peds.2018-0606DOI Listing
December 2018

Evidence-based skin care in preterm infants.

Pediatr Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University of California, San Diego School of Medicine, San Diego, California.

Most guidelines on neonatal skin care emphasize issues pertaining to healthy, term infants. Few address the complex task of skin barrier maintenance in preterm, very preterm, and extremely preterm infants. Here, we provide an evidence-based review of the literature on skin care of preterm neonates. Read More

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http://dx.doi.org/10.1111/pde.13725DOI Listing
December 2018
2 Reads

Hypothermia and cardiac electrophysiology - a systematic review of clinical and experimental data.

Cardiovasc Res 2018 Dec 13. Epub 2018 Dec 13.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.

Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognised as a principal cause for a high mortality rate in these patients. We assessed both clinical and experimental literature through a systematic literature search in the PubMed database, to review the effect of hypothermia on cardiac electrophysiology. Read More

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http://dx.doi.org/10.1093/cvr/cvy305DOI Listing
December 2018

Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions.

Neuropharmacology 2018 Dec 10;146:252-263. Epub 2018 Dec 10.

Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China. Electronic address:

Enhanced cholinergic activity contributes to the production of complex autonomic manifestations of motion sickness (MS). However, whether anti-cholinergics exert their anti-MS effects through central or peripheral actions remained unclarified. In the present study, we investigated the effects of mecamylamine (MEC) and scopolamine (SCOP) on rotation-induced gastrointestinal symptoms (conditioned gaping and defecation), locomotion disturbances (hypoactivity and impaired balance performance), hypothermia as well as Fos expression in vestibulo-autonomic regions in rats. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.12.006DOI Listing
December 2018

Perioperative Outcomes of Using Different Temperature Management Strategies on Pediatric Patients Undergoing Aortic Arch Surgery: A Single-Center, 8-Year Study.

Front Pediatr 2018 27;6:356. Epub 2018 Nov 27.

Department of Cardiopulmonary Bypass, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.

With the widespread application of regional low-flow perfusion (RLFP), development of surgical techniques, and shortened circulatory arrest time, deep hypothermia is indispensable for organ protection. Clinicians have begun to increase the temperature to reduce hypothermia-related adverse outcomes. The aim of this study was to evaluate the safety and efficacy of elevated temperatures during aortic arch surgery with lower body circulatory arrest (LBCA) combined with RLFP. Read More

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http://dx.doi.org/10.3389/fped.2018.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277883PMC
November 2018

Hypothermic treatment after computer-controlled compression in minipig: A preliminary report on the effect of epidural vs. direct spinal cord cooling.

Exp Ther Med 2018 Dec 5;16(6):4927-4942. Epub 2018 Oct 5.

Institute of Neurobiology, Biomedical Research Center, Slovak Academy of Sciences, 040 01 Košice, Slovakia.

The aim of the present study was to investigate the therapeutic efficacy of local hypothermia (beginning 30 min post-injury persisting for 5 h) on tissue preservation along the rostro-caudal axis of the spinal cord (3 cm cranially and caudally from the lesion site), and the prevention of injury-induced functional loss in a newly developed computer-controlled compression model in minipig (force of impact 18N at L3 level), which mimics severe spinal cord injury (SCI). Minipigs underwent SCI with two post-injury modifications (durotomy vs. intact dura mater) followed by hypothermia through a perfusion chamber with cold (epidural t≈15°C) saline, DMEM/F12 or enriched DMEM/F12 (SCI/durotomy group) and with room temperature (t≈24°C) saline (SCI-only group). Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6831
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http://dx.doi.org/10.3892/etm.2018.6831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257352PMC
December 2018
1 Read

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.007DOI Listing
November 2018

Validation of non-invasive brain temperature estimation models during swine therapeutic hypothermia.

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF.

Objectives: This paper introduces a mathematical model that can estimate deep brain temperature during therapeutic hypothermia based on a double sensor method. Although the cerebral temperature is more important than the non-cerebral core temperature during therapeutic hypothermia, pulmonary artery, rectal, and esophageal measurements (i.e. Read More

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http://dx.doi.org/10.1088/1361-6579/aaf0c1DOI Listing
November 2018

Bleeding Complications After Cardiac Arrest and Targeted Temperature Management, a Post Hoc Study of the Targeted Temperature Management Trial.

Ther Hypothermia Temp Manag 2018 Dec 6. Epub 2018 Dec 6.

1 Department of Clinical Sciences, Anesthesia and Intensive Care, Skane University Hospital, Lund University , Lund, Sweden .

Target Temperature Management (TTM) is standard care following out of hospital cardiac arrest (OHCA). The aim of the study was to evaluate if treatment temperature (33°C or 36°C) or other predefined variables were associated with the occurrence of bleeding in the TTM study. This study is a predefined, post hoc analysis of the TTM trial, a multinational randomized controlled trial comparing treatment at 33°C and 36°C for 24 hours after OHCA with return of spontaneous circulation. Read More

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http://dx.doi.org/10.1089/ther.2018.0024DOI Listing
December 2018

Fulminant acute disseminated encephalomyelitis in children.

Brain Dev 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, St Mary's Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka 830-8543, Japan; Research Centre for Children and Research Centre for Rett Syndrome, St Mary's Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka 830-8543, Japan. Electronic address:

Acute disseminated encephalomyelitis (ADEM) is a typically monophasic inflammatory demyelinating disease of the central nervous system with a favorable outcome. However, 2% of ADEM involves acute hemorrhagic leukoencephalitis (AHLE), which is a fulminant and hyperacute variant of ADEM with a poor outcome and high mortality. There are limited case reports of fulminant ADEM including AHLE in children. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.11.007DOI Listing
December 2018

The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys.

Biomed Res Int 2018 12;2018:7465435. Epub 2018 Nov 12.

"Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland.

Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0. Read More

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http://dx.doi.org/10.1155/2018/7465435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260524PMC
November 2018

Placental Circulation Intact Trial (PCI-T)-Resuscitation With the Placental Circulation Intact vs. Cord Milking for Very Preterm Infants: A Feasibility Study.

Front Pediatr 2018 27;6:364. Epub 2018 Nov 27.

Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Preterm newborns receiving briefly delayed cord clamping or cord milking at birth have better neonatal outcomes. However, the time frame in which both these procedures are performed (< 60 s of life) is too short to explore the possible beneficial effects on early infant postnatal adaptation and outcomes of a prolonged transfusion strategy associated with neonatal respiration. We have designed a randomized, multicenter, controlled two-phase study: phase 1 to assess the feasibility of carrying out the protocol in a large randomized trial, and phase 2 to assess the efficacy of bedside assistance with intact placental circulation for 3 min in comparison to cord milking to improve outcome in the neonatal period; we present here the feasibility and safety phase of the study. Read More

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http://dx.doi.org/10.3389/fped.2018.00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277460PMC
November 2018

A retrospective evaluation of the risk of bias in perioperative temperature metrics.

J Clin Monit Comput 2018 Dec 8. Epub 2018 Dec 8.

Department of Anesthesiology, Vanderbilt University Medical Center, 1211 21st Avenue South, MAB 422F, Nashville, TN, 37212, USA.

The prevention and treatment of hypothermia is an important part of routine anesthesia care. Avoidance of perioperative hypothermia was introduced as a quality metric in 2010. We sought to assess the integrity of the perioperative hypothermia metric in routine care at a single large center. Read More

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http://link.springer.com/10.1007/s10877-018-0233-1
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http://dx.doi.org/10.1007/s10877-018-0233-1DOI Listing
December 2018
2 Reads

Reinforcing kangaroo mother care uptake in resource limited settings.

Matern Health Neonatol Perinatol 2018 4;4:26. Epub 2018 Dec 4.

Pacific Medical College and Hospital, Udaipur, 313 001 India.

Background: The national and global coverage of kangaroo mother care (KMC) remains low. Hence, adjuncts to KMC may be necessary, especially on day1 of life when neonatal mortality is high. It is important to provide warmth and reduce mortality in preterm low birth weight (LBW) infants in the community/hospital setting. Read More

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http://dx.doi.org/10.1186/s40748-018-0091-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278098PMC
December 2018

Mild hypothermia is ineffective to protect against myocardial injury induced by chemical anoxia or forced calcium overload.

J Cardiovasc Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan.

Although hypothermia suppresses myocardial ischemia/reperfusion injury, whether it also protects the myocardium against cellular stresses such as chemical anoxia and calcium overload remains unknown. We examined the effect of mild hypothermia (33 °C) on myocardial injury during ischemia/reperfusion, local administration of sodium cyanide (chemical anoxia), or local administration of maitotoxin (forced Ca overload) using cardiac microdialysis applied to the feline left ventricle. Baseline myoglobin levels (in ng/ml) were 237 ± 57 and 150 ± 46 under normothermia and hypothermia, respectively (mean ± SE, n = 6 probes each). Read More

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http://dx.doi.org/10.1097/FJC.0000000000000639DOI Listing
November 2018

Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling.

J Perinat Med 2018 Dec 7. Epub 2018 Dec 7.

Pediatrics, Division of Neonatology, New York University Medical Center, New York, NY, USA.

Background Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature. Read More

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http://dx.doi.org/10.1515/jpm-2018-0302DOI Listing
December 2018

Treatment options in pediatric super-refractory status epilepticus.

Brain Dev 2018 Dec 7. Epub 2018 Dec 7.

Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand. Electronic address:

Background: Super-refractory status epilepticus (SRSE) is a seizure that continues >24 h after anesthesia, or recurs on the reduction of anesthesia. SRSE is extremely difficult-to-control and associated with poor outcome. To date, optimal therapy and outcome data in children is limited. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.11.011DOI Listing
December 2018

Total arch replacement using a 4-branched graft with antegrade cerebral perfusion.

J Thorac Cardiovasc Surg 2018 Oct 17. Epub 2018 Oct 17.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

Objective: Total arch replacement (TAR) is an established standard surgical procedure. We report >1000 cases of TAR using a 4-branched graft with antegrade cerebral perfusion (ACP) during a 15-year period.

Methods: Since May 2001, 1005 patients who underwent total aortic replacement (mean age 69. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.09.112DOI Listing
October 2018

Liposomes with cyclic RGD peptide motif triggers acute immune response in mice.

J Control Release 2018 Dec 5;293:201-214. Epub 2018 Dec 5.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education and PLA, Shanghai 201203, China; The Department of Integrative Medicine, Huashan Hospital, Fudan University, and The Institutes of Integrative Medicine of Fudan University, Shanghai 200041, China; Minhang Branch, Zhongshan Hospital and Institute of Fudan-Minghang Academic Health System, Minghang Hospital, Fudan University, Shanghai 201199, China. Electronic address:

Liposomes with peptides motifs have been widely applied for targeted delivery of anticancer drugs. However, few studies have questioned whether peptide modification on liposomes may induce serious toxicity associated with immune stimulation. Here, we report that display of a tumor targeting cyclic RGD peptide (e. Read More

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http://dx.doi.org/10.1016/j.jconrel.2018.12.003DOI Listing
December 2018

Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury.

Artif Cells Nanomed Biotechnol 2018 Dec 11:1-8. Epub 2018 Dec 11.

a Department of Orthopedics , Peking University Third Hospital , Beijing , China.

In recent years, systemic hypothermia has taken the spotlight for its use in spinal cord injury (SCI) research fields, but detailed molecular mechanisms are still not fully understood. In this study, we use an online-electrochemical system (OECS) to in vivo continuously monitor the ascorbate of the rats' spinal cord. We find that the basal level of ascorbate in rat spinal cord is 1. Read More

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http://dx.doi.org/10.1080/21691401.2018.1541136DOI Listing
December 2018

Early-Stage Translational Research in Perinatal Medicine.

Neonatology 2018 Dec 6;115(2):182-188. Epub 2018 Dec 6.

Liggins Institute, University of Auckland, Auckland, New

Background: Pre-clinical research, which encompasses studies in animals and in the laboratory, has made significant contributions to the improvement of neonatal outcomes.

Methods: Here, we describe examples of how pre-clinical research can be the starting point on the journey to the development of new interventions to improve neonatal care and outcomes and discuss recent progress in ensuring methodological and ethical rigour in pre-clinical research involving animal models.

Results: Studies in pregnant sheep led to the serendipitous discovery that preterm lambs born after exogenous corticosteroid exposure were able to aerate their lungs. Read More

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https://www.karger.com/Article/FullText/493004
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http://dx.doi.org/10.1159/000493004DOI Listing
December 2018
7 Reads

Effects of cold on murine brain mitochondrial function.

PLoS One 2018 6;13(12):e0208453. Epub 2018 Dec 6.

Department of Zoology, University of British Columbia, Vancouver, British Columbia, CAN.

Therapeutic hypothermia is a strategy that reduces metabolic rate and brain damage during clinically-relevant hypoxic events. Mitochondrial respiration is compromised by hypoxia, with deleterious consequences for the mammalian brain; however, little is known about the effects of reduced temperature on mitochondrial metabolism. Therefore, we examined how mitochondrial function is impacted by temperature using high resolution respirometry to assess electron transport system (ETS) function in saponin-permeabilized mouse brain at 28 and 37°C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208453PLOS
December 2018
1 Read

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires. Argentina.

Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Read More

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http://dx.doi.org/10.2174/1570159X17666181206101314DOI Listing
December 2018
3 Reads

Forced-Air Warming and Resistive Heating Devices. Updated Perspectives on Safety and Surgical Site Infections.

Front Surg 2018 21;5:64. Epub 2018 Nov 21.

Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.

Perioperative hypothermia is one of the most common phenomena seen among surgical patients, leading to numerous adverse outcomes such as intraoperative blood loss, cardiac events, coagulopathy, increased hospital stay and associated costs. Forced air warming (FAW) and resistive heating (RH) are the two most commonly used and widely studied devices to prevent perioperative hypothermia. The effect of FAW on operating room laminar flow and surgical site infection is unclear and we initiated an extensive literature search in order to get a scientific insight of this aspect. Read More

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http://dx.doi.org/10.3389/fsurg.2018.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258796PMC
November 2018
1 Read

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.10.034DOI Listing
October 2018
2 Reads

Effects of Underrunning Water Bathing and Immersion Tub Bathing on Vital Signs of Newborn Infants: A Comparative Analysis.

Adv Neonatal Care 2018 Dec;18(6):E3-E12

Pediatric Nursing Department, Florence Nightingale Faculty of Nursing, Istanbul University, Şişli, Turkey.

Background: Newborn infants are susceptible to hypothermia during bathing due to environmental conditions.

Purpose: This study examined the effects of 2 common newborn bathing methods used in Turkey, underrunning water bathing (URWB) and immersion tub bathing (ITB), on infant heart rate (HR), oxygen saturation, and body temperature.

Methods: In this randomized controlled study, 44 newborns were allocated to the ITB group and 36 newborns to the URWB group. Read More

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http://dx.doi.org/10.1097/ANC.0000000000000484DOI Listing
December 2018
1 Read

Late initiation of therapeutic hypothermia: not the new standard of care.

Acta Paediatr 2018 Dec 2. Epub 2018 Dec 2.

Department of Pediatrics, Section of Neonatology, University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1111/apa.14671DOI Listing
December 2018
1 Read

Histiocytic Ulcerative Colitis in an American Staffordshire Terrier.

J Comp Pathol 2018 Nov 20;165:40-44. Epub 2018 Oct 20.

Department of Veterinary Pathology, Brazil.

A 9-year-old female American Staffordshire terrier was presented to a veterinary hospital with diarrhoea, severe prostration, hypothermia, dehydration and anaemia. The dog died 6 days after the first consultation. At necropsy examination the serosa of the large intestine showed a granular appearance and the mucosa was thickened, ulcerated and red, with prominent folding. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.006DOI Listing
November 2018

Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial.

BMC Anesthesiol 2018 Nov 30;18(1):179. Epub 2018 Nov 30.

Department of Anesthesia, Fayoum University, Fayoum, Egypt.

Background: Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks.

Methods: This randomized placebo-controlled trial included 120 patients allocated equally in three groups. Read More

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http://dx.doi.org/10.1186/s12871-018-0640-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267838PMC
November 2018
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Diagnostic evaluation of risk for bleeding in cardiac surgery with extracorporeal circulation.

Rev Lat Am Enfermagem 2018 Nov 29;26:e3092. Epub 2018 Nov 29.

Universidade Federal do Rio de Janeiro, Escola de Enfermagem Anna Nery, Rio de Janeiro, RJ, Brazil.

Objective: to identify the risk factors associated with cases of excessive bleeding in patients submitted to cardiac surgery with extracorporeal circulation.

Method: case-control study on the factors of risk for bleeding based on the analysis of data from the medical charts of 216 patients submitted to cardiac surgery with elective extracorporeal circulation during a three-year period.

Results: variables that are commonly associated with excessive bleeding in studies in the field were analyzed, and the following were considered as risk factors for the nursing diagnosis "risk for bleeding" (00206) in cardiac surgery with extracorporeal circulation: Body mass index lower than 26. Read More

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http://dx.doi.org/10.1590/1518-8345.2523.3092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280528PMC
November 2018
2 Reads

Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus.

Continuum (Minneap Minn) 2018 Dec;24(6):1683-1707

Purpose Of Review: Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus can be life-threatening conditions. This article presents an overview of the three conditions and discusses their management and outcomes.

Recent Findings: Status epilepticus was previously defined as lasting for 30 minutes or longer but now is more often defined as lasting 5 minutes or longer. Read More

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http://Insights.ovid.com/crossref?an=00132979-201812000-0000
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http://dx.doi.org/10.1212/CON.0000000000000668DOI Listing
December 2018
8 Reads

Cerebral Edema and Elevated Intracranial Pressure.

Authors:
Matthew A Koenig

Continuum (Minneap Minn) 2018 Dec;24(6):1588-1602

Purpose Of Review: This article reviews the management of cerebral edema, elevated intracranial pressure (ICP), and cerebral herniation syndromes in neurocritical care.

Recent Findings: While corticosteroids may be effective in reducing vasogenic edema around brain tumors, they are contraindicated in traumatic cerebral edema. Mannitol and hypertonic saline use should be tailored to patient characteristics including intravascular volume status. Read More

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http://dx.doi.org/10.1212/CON.0000000000000665DOI Listing
December 2018
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Management Strategies for Intracranial Pressure Crises in Subarachnoid Hemorrhage.

J Intensive Care Med 2018 Dec 4:885066618813073. Epub 2018 Dec 4.

4 Department of Neurology, Division of Neuroendovascular Surgery and Neurocritical Care, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Objectives: Standard management strategies for lowering intracranial pressure (ICP) in traumatic brain injury has been well-studied, but the use of lesser known interventions for ICP in subarachnoid hemorrhage (SAH) remains elusive. Searches were performed in PubMed and EBSCO Host to identify best available evidence for evaluation and management of medically refractory ICP in SAH. The role of standard management strategies such as head elevation, hyperventilation, mannitol and hypertonic saline as well as lesser known management such as sodium bicarbonate, indomethacin, tromethamine, decompressive craniectomy, decompressive laparotomy, hypothermia, and barbiturate coma are reviewed. Read More

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http://dx.doi.org/10.1177/0885066618813073DOI Listing
December 2018
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Total tiroidectomy in patient with McArdle's syndrome: Anesthetic management.

Rev Esp Anestesiol Reanim 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Anestesiología y Reanimación, Hospital de Jerez de la Frontera, Jerez de la Frontera (Cádiz), España.

McArdle disease or type V glycogenosis is a rare metabolic myopathy consisting of muscle loss and weakness. These patients have risks associated with anaesthesia. They can present with hypoglycaemia, rhabdomyolysis, acute renal failure, and electrolyte changes. Read More

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http://dx.doi.org/10.1016/j.redar.2018.10.004DOI Listing
November 2018
6 Reads

A thermoregulation model for whole body cooling hypothermia.

J Therm Biol 2018 Dec 20;78:122-130. Epub 2018 Sep 20.

Civil Engineering Program, COPPE/Federal University of Rio de Janeiro Technological Center, Ilha do Fundão, CEP 21945-970 Rio de Janeiro, Brazil. Electronic address:

This paper presents a thermoregulation model based on the finite element method to perform numerical analyses of brain cooling procedures as a contribution to the investigation on the use of therapeutic hypothermia after ischemia in adults. The use of computational methods can aid clinicians to observe body temperature using different cooling methods without the need of invasive techniques, and can thus be a valuable tool to assist clinical trials simulating different cooling options that can be used for treatment. In this work, we developed a finite element method (FEM) package using isoparametric linear three-dimensional elements which is applied to the solution of the continuum bioheat Pennes equation. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2018.08.019DOI Listing
December 2018
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A new look at survival times during cold water immersion.

J Therm Biol 2018 Dec 18;78:100-105. Epub 2018 Sep 18.

Laboratory for Exercise and Environmental Medicine, 108 Frank Kennedy, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2.

This paper presents an expanded dataset for survival times during cold water immersion. In 1946, the first set of human data for cold water survival was derived from the US Navy medical reports during WWII. Although this is the largest and most widely used data source, it has only 23 data points and immersion times are less than 5. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2018.08.022DOI Listing
December 2018
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Infections with Mycobacterium chimaera and open chest surgery. An unresolved problem.

Med Clin (Barc) 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Medicina Preventiva y Epidemiología, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Mycobacterium chimaera (M. chimaera) is a non-tuberculous mycobacterium of the Mycobacterium avium complex. Between 2013 and April 2018, more than 140 cases of severe infection have been identified, all of them in patients who had undergone cardiothoracic surgery with extracorporeal circulation. Read More

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http://dx.doi.org/10.1016/j.medcli.2018.10.013DOI Listing
November 2018
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[Methods of preserving donor corneas].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):238-243

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Corneal transplantation is the most successful and frequently performed allotransplantation procedure. Benign outcome of penetrating and posterior keratoplasty depends on viability of the corneal tissue and presence of the proper endothelial layer, which retaining is one of the main objectives of preservation of donor material. Methods designed to reach this goal may be classified according to storage duration as short-term (storage in a moist chamber), medium-term (hypothermia), long-term (organ cultivation) and unlimited (cryopreservation). Read More

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http://www.mediasphera.ru/issues/vestnik-oftalmologii/2018/5
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http://dx.doi.org/10.17116/oftalma2018134051238DOI Listing
January 2018
3 Reads

What is the predictor of the intraoperative body temperature in abdominal surgery?

J Anesth 2018 Nov 29. Epub 2018 Nov 29.

Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: Inadvertent hypothermia is a relatively common intraoperative complication. Few studies have investigated predictors of body temperature change or the effect of the blanket type used with a forced-air warming device during the intraoperative period. We investigated the predictive factors of intraoperative body temperature change in scheduled abdominal surgery. Read More

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http://dx.doi.org/10.1007/s00540-018-2585-6DOI Listing
November 2018

Antenatal care utilization increase the odds of women knowledge on neonatal danger sign: a community-based study, eastern Ethiopia.

BMC Res Notes 2018 Nov 29;11(1):845. Epub 2018 Nov 29.

School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, P.O.B. 235, Harar, Ethiopia.

Objective: This study, aimed to determine women knowledge on key neonatal dander sign and associated factors among women recently gave birth in eastern Ethiopia.

Results: Of the 757 women interviewed, fever was reported as a neonatal danger sign by 255 (33.7%) followed by poor sucking (24. Read More

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http://dx.doi.org/10.1186/s13104-018-3957-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267923PMC
November 2018

Choice of vehicle affects pyraclostrobin toxicity in mice.

Chemosphere 2018 Nov 23;218:501-506. Epub 2018 Nov 23.

Department of Cell Biology and Physiology, and UNC Neuroscience Center, The University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. In toxicity studies that were used to estimate the safety factor, pyraclostrobin was added to animal feed or to aqueous vehicles. However, foods containing residues of pyraclostrobin and other strobilurin fungicides (azoxystrobin, trifloxystrobin, fluoxastrobin) are frequently prepared in vegetable oil prior to human consumption. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.126DOI Listing
November 2018
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How to avoid severe coronary vasoconstriction in potassium induced cardioplegia.

Scand Cardiovasc J 2018 Nov 29:1-18. Epub 2018 Nov 29.

a Department of Cardiothoracic Surgery , Skåne University Hospital, Lund and Lund University , Lund , Sweden.

Objectives: The aim of this study was to investigate how high K concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction.

Design: Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O and 5% CO. Read More

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http://dx.doi.org/10.1080/14017431.2018.1552794DOI Listing
November 2018
1 Read