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Front Endocrinol (Lausanne) 2022 3;13:877152. Epub 2022 May 3.

Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, United States.

Thermogenic adipocytes possess a promising approach to combat obesity with its capability promoting energy metabolism. We previously discovered that deletion of (GPRKO), a presumably membrane-associated estrogen receptor, protected female mice from developing obesity, glucose intolerance, and insulin resistance when challenged with a high-fat diet (HFD). , the metabolic phenotype of wild type (WT) and GPRKO female mice were measured weekly. Read More

Front Surg 2022 3;9:899753. Epub 2022 May 3.

Department of Emergency Medicine, Chongqing Qijiang District People's Hospital, Chongqing, China.

Objective: To investigate the efficacy of xuebijing combined with ulinastatin in the treatment of traumatic sepsis and analyze the effects on inflammatory factors and immune function of patients.

Methods: 182 patients with traumatic sepsis were selected from June 2017 to September 2021 in our hospital. The patients were divided into the control group and the observation group. Read More

Can J Anaesth 2022 May 18. Epub 2022 May 18.

Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.

Purpose: Brain death/death by neurologic criteria (BD/DNC) may be determined in many countries by a clinical examination that shows coma, brainstem areflexia, and apnea, provided the conditions causing reversible loss of brain function are excluded a priori. To date, accounts of recovery from BD/DNC in adults have been limited to noncompliance with guidelines.

Clinical Features: We report the case of a 72-yr-old man with a combined primary infratentorial (hemorrhagic) and secondary global (anoxic) brain lesion in whom decompressive craniectomy of the posterior fossa and six-hour therapeutic hypothermia (33-34°C) followed by 8-hour rewarming to ≥ 36°C were conducted. Read More

Clin Med (Lond) 2022 May;22(3):285-286

St Vincent De Paul Long-Term Care Facility, Luqa, Malta.

Introduction: We describe a case of olanzapine-induced hypothermia and hand oedema in an older adult with behavioural and psychological symptoms of dementia (BPSD).

Case Presentation: An 82-year-old woman with hypothyroidism and dementia was reviewed by the geriatric team at a nursing home in view of lethargy and an unrecordable oral temperature. She was noted to have a bilateral hand oedema and right basal crackles. Read More

J Am Vet Med Assoc 2022 May 18:1-8. Epub 2022 May 18.

Objective: To compare results for body (esophageal) temperature measurements obtained during celiotomy in normothermic (presurgical) canine patients receiving routine heat support versus routine heat support plus supplemental support (consisting of covering the thorax in a reflective blanket and placing reflective blankets plus wool socks on 3 limbs) in a prospective randomized controlled clinical trial.

Animals: 44 dogs requiring celiotomy that were presented sequentially to an emergency and specialty referral veterinary hospital.

Procedures: The 44 dogs undergoing celiotomy were randomly assigned to 2 groups. Read More

Methods Mol Biol 2022 ;2447:233-246

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

In plants, the response to stress, such as salinity, pathogen attack, drought, high concentration of metals, hyperthermia, and hypothermia, is usually accompanied by potassium ion (K) leakage from the cytosol to the cell wall, mediated by plasma membrane cation conductivity. Stress-induced electrolyte leakage co-occurs with accumulation of reactive oxygen species (ROS) and calcium ions (Ca) and often results in programmed cell death (PCD). The development of X-ray and mass spectrometry (MS) based imaging techniques has enabled insight into the spatial tissue and cell-specific redistribution of major and trace elements during the stress response. Read More

BMC Pediatr 2022 May 17;22(1):290. Epub 2022 May 17.

Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity. Effective indicators for the early diagnosis of brain injury after HIE and prognosis are lacking. This study aimed to examine the predictive value of serum neuron-specific enolase (NSE), amplitude-integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), alone and in combination, for the neurological outcomes in neonates with HIE. Read More

Sci Rep 2022 May 17;12(1):8179. Epub 2022 May 17.

School of Water Resource & Environment, China University of Geosciences, Beijing, 100083, China.

High temperature impacts the performance of marathon athletes, and hypothermia harms athletes. Twenty-one runners died, and eight were injured in the China Baiyin marathon on May 22, 2021. It's a typical human life test. Read More

Am J Prev Med 2022 May 14. Epub 2022 May 14.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: The proportion of fatal nontraffic injuries that involve high levels of alcohol use or alcohol intoxication was assessed by cause of injury to generate alcohol-attributable fractions. Updated alcohol-attributable fractions can contribute to improved estimates of the public health impact of excessive alcohol use.

Methods: Peer-reviewed and gray literature for 1995-2019 on 15 causes of fatal nontraffic injuries in the U. Read More

JAMA 2022 05;327(19):1928

Department of Emergency Medicine and Critical Care, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.

JAMA 2022 05;327(19):1927-1928

Division of Cardiothoracic Intensive Care, ASST Spedali Civili, Brescia, Italy.

JAMA 2022 05;327(19):1928-1929

Université de Lorraine, Centre d'Investigations Cliniques Plurithématique CHRU de Nancy, Nancy, France.

Clin Neuropharmacol 2022 May-Jun 01;45(3):74-77. Epub 2022 Apr 14.

Department of Physical Medicine and Rehabilitation, Rutgers-New Jersey Medical School, Newark, NJ.

Objectives: Antipsychotic-induced hypothermia is an uncommon type of secondary hypothermia resulting from neurotransmitter derangements within the nervous system thermoregulation pathway. The most common causative medications include olanzapine, haloperidol, and risperidone, with one published report of aripiprazole. Most individuals who develop antipsychotic-induced hypothermia receive neuroleptic treatment for psychiatric disorder management, with significantly fewer occurrences in those with neurologic disorders. Read More

Eur Heart J Acute Cardiovasc Care 2022 May 17. Epub 2022 May 17.

Duke Clinical Research Institute, Duke Health, 300 W Morgan Street, Durham, NC 27701, USA.

Targeted temperature management (TTM) has become a cornerstone in the treatment of comatose post-cardiac arrest patients over the last two decades. Belief in the efficacy of this intervention for improving neurologically intact survival was based on two trials from 2002, one truly randomized-controlled and one small quasi-randomized trial, without clear confirmation of that finding. Subsequent large randomized trials reported no difference in outcomes between TTM at 33 vs. Read More

J Card Surg 2022 May 16. Epub 2022 May 16.

First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece.

A hypothermic circulatory arrest is usually used to correct thoracic aorta pathologies. The emergency treatment of acute type A aortic dissection and elective repair of aortic arch pathologies are the most common indications for using hypothermic circulatory arrest. A hypothermic circulatory arrest can also be used for surgical pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension. Read More

J Perinatol 2022 May 16. Epub 2022 May 16.

Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Stanford, CA, USA.

Objective: To evaluate multi-organ dysfunction (MOD) in newborns treated with therapeutic hypothermia (TH) for hypoxic ischemic encephalopathy (HIE), and to compare MOD in those with normal/mild magnetic resonance imaging (MRI) findings to those with moderate to severe MRI findings or death.

Study Design: Retrospective single-center observational study of infants treated with TH. A total of 16 parameters across 7 organ systems were analyzed. Read More

Front Physiol 2022 29;13:901908. Epub 2022 Apr 29.

Department of Clinical Medicine, Anaesthesia and Critical Care Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming on blood coagulation in an intact porcine model. Read More

Semin Spine Surg 2022 May 8:100961. Epub 2022 May 8.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Quality improvement has become a foundation of neonatal care. Structured approaches to improvement can standardize practices, improve teamwork, engage families, and improve outcomes. The delivery room presents a unique environment for quality improvement; optimal delivery room care requires advanced preparation, adequately trained providers, and carefully coordinated team dynamics. Read More

Front Pediatr 2022 29;10:850654. Epub 2022 Apr 29.

Department of Pediatrics, Bernard and Millie Duker Children's Hospital at Albany Medical Center, Albany, NY, United States.

Objective: More women are obese at their first prenatal visit and then subsequently gain further weight throughout pregnancy than ever before. The impact on the infant's development of neonatal hypoxic ischemic encephalopathy (HIE) has not been well studied. Using defined physiologic and neurologic criteria, our primary aim was to determine if maternal obesity conferred an additional risk of HIE. Read More

Appl Bionics Biomech 2022 6;2022:7596426. Epub 2022 May 6.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The prognosis of patients with subarachnoid hemorrhage is influenced by many factors. Neuron-specific enolase (NSE) is a biological marker of neurological damage. This study aimed to determine the related prognostic factors and whether or not the maximum NSE value (NSE) has a threshold between good and poor prognosis in aneurysmal subarachnoid hemorrhage (aSAH). Read More

Rev Esp Cardiol (Engl Ed) 2022 May 12. Epub 2022 May 12.

Unidad de Cuidados Agudos Cardiovasculares, Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain; Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.

Introduction And Objectives: Myocardial dysfunction contributes to early mortality (24-72 hours) among survivors of a cardiac arrest (CA). The benefits of mechanical support in refractory shock should be balanced against the patient's potential for neurological recovery. To date, these early treatment decisions have been taken based on limited information leading mainly to undertreatment. Read More

Brain Behav Immun 2022 May 13;104:39-53. Epub 2022 May 13.

APC Microbiome Ireland, University College Cork, Ireland; Neuropharmacology Research Group, Department of Pharmacology & Therapeutics, University College Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Ireland.

Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairment or global loss of cognitive function. Currently there is no clearly defined neurochemical basis of septic encephalopathy. Moreover, the lingering neurological complications associated with the severe acute respiratory syndrome CoV 2 (SARS-CoV-2) and the significant worsening in outcomes for those individuals with SARS-Cov-2 following sepsis underscore the need to define factors underlying the susceptibility to acute toxic encephalitis. Read More

BMC Pediatr 2022 May 14;22(1):281. Epub 2022 May 14.

Department of Neonatology, Hebei Petro China Central Hospital, Langfang, 065000, Hebei, China.

Background: Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89. Read More

Int J Environ Res Public Health 2022 Apr 26;19(9). Epub 2022 Apr 26.

Department of Anesthesiology and Intensive Care Medicine, St. John of God Hospital, Paracelsus Medical University, 5010 Salzburg, Austria.

Snow sports in the backcountry have seen a steep increase in popularity, and therefore preparedness for efficient companion and organized rescue is important. While technical rescue skills are widely taught, there is a lack of knowledge regarding first aid for avalanche patients. The stressful and time-critical situation for first responders requires a rule-based decision support tool. Read More

Int J Mol Sci 2022 Apr 30;23(9). Epub 2022 Apr 30.

Biochemistry Department, CHU Poitiers, 86021 Poitiers, France.

Organ transplantation remains the treatment of last resort in case of failure of a vital organ (lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for which supplementary treatments exist. It remains the best alternative both in terms of quality-of-life and life expectancy for patients and of public health expenditure. Unfortunately, organ shortage remains a widespread issue, as on average only about 25% of patients waiting for an organ are transplanted each year. Read More

BMC Cardiovasc Disord 2022 May 13;22(1):216. Epub 2022 May 13.

Department of Cardiovascular Surgery, Juntendo University, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: In patients with systemic lupus erythematosus (SLE), lengthy treatment and long-term steroid use are the main risk factors for developing aortic aneurysms or aortic dissections. In patients with cardiac tamponade, hemodynamic collapse may lead to acute renal and hepatic failure.

Case Presentation: We report the successful treatment of a 55-year-old woman with SLE since the age of 21. Read More

Sci Rep 2022 May 13;12(1):7945. Epub 2022 May 13.

Center for Human Development and Family Science, Department of Neonatology and Pediatrics, Nagoya City University Graduate School of Medical Sciences, Aichi, Nagoya, 467-8601, Japan.

This study investigated the 3-year clinical outcomes in relation to the severity of encephalopathy in high-survival infants who underwent therapeutic hypothermia. This retrospective observational study was conducted in level II/III neonatal intensive care units in Japan. The nationwide cohort included 474 infants registered in the Baby Cooling Registry of Japan between January 2012 and December 2016. Read More

Eur J Pharmacol 2022 May 10;926:175019. Epub 2022 May 10.

Department of Psychology, California State University, San Bernardino, CA, USA. Electronic address:

Serotonin 5-HT receptor agonists increase locomotor activity of both preweanling and adult rodents. The part played by the 5-HT receptor in locomotion is less certain, with preliminary evidence suggesting that the actions of 5-HT receptor agonists are not uniform across ontogeny. To more fully examine the role of 5-HT receptors, locomotor activity and axillary temperatures of preweanling and adult male and female rats was assessed. Read More

J Pediatr Pharmacol Ther 2022 9;27(4):352-357. Epub 2022 May 9.

Department of Pharmacy, University of Chicago Medicine Comer Children's Hospital, Chicago, IL.

Objective: Therapeutic hypothermia reduces the risk of death and major disability in neonates with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Opioids and benzodiazepines are used to manage agitation but contribute to hemodynamic and respiratory instability. The objective of this study was to evaluate the safety and efficacy of dexmedetomidine (DEX) compared with fentanyl (FENT) in neonates with HIE undergoing therapeutic hypothermia. Read More

J Perinatol 2022 May 12. Epub 2022 May 12.

Department of Paediatrics, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada.

Objective: To characterize variations in practices and outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) across Canadian tertiary Neonatal Intensive Care Units (NICUs).

Study Design: Retrospective study of neonates admitted for HIE and treated with TH in 24 tertiary NICUs from the Canadian Neonatal Network, 2010-2020. The two primary outcomes of mortality before discharge and MRI-detected brain injury were compared across NICUs using adjusted standardized ratios (SR) with 95% CI. Read More