Search Our Scientific Publications & Authors

Korean J Anesthesiol 2021 May 13. Epub 2021 May 13.

Department of Thoracic and Cardiovascular surgery, Soonchunhyang University Hospital Seoul, Republic of Korea.

Background: We compared the upper and lower body forced-air blanket to prevent perioperative hypothermia, defined as a reduction in body temperature to <36.0°C during the perioperative period, in patients who underwent spinal surgery in prone position.

Methods: A total of 120 patients scheduled for elective spine surgery under general anesthesia were divided into an upper warming group (n = 60) and a lower warming group (n = 60). Read More

Brain Commun 2021 26;3(2):fcab048. Epub 2021 Mar 26.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan.

Hypoxic ischaemia encephalopathy is the major cause of brain injury in new-borns. However, to date, useful biomarkers which may be used to early predict neurodevelopmental impairment for proper commencement of hypothermia therapy is still lacking. This study aimed to determine whether the early neuroimaging characteristics and ultrastructural correlates were associated with different injury progressions and brain damage severity outcomes after neonatal hypoxic ischaemia. Read More

FASEB J 2021 Jun;35(6):e21616

Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

IgE-dependent/independent activation of mast cell (MC) has been assumed to play a host defensive role against venom injection in skin. However, its detailed mechanisms remain unknown. We aimed to investigate the contribution of MC-derived prostaglandin D (PGD )-mediated signaling in host defense against bee venom (BV). Read More

Metab Brain Dis 2021 May 12. Epub 2021 May 12.

Department of Critical Care Medicine, Hainan Medical University, No.48, Baishuitang Road, Haikou, 460106, Hainan, China.

Therapeutic hypothermia (TH) is a promising neuroprotective agent for treating stroke. However, its clinical application was limited by the impractical duration. Icariin (ICA) were reported to have therapeutic effect on cerebral ischemia. Read More

Shock 2021 May 11. Epub 2021 May 11.

Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France Ecole nationale vétérinaire d'Alfort, IMRB, F-94700 Maisons-Alfort, France.

Abstract: Mitochondria is often considered as the common nexus of cardiac and cerebral dysfunction after cardiac arrest. Here, our goal was to determine whether the time course of cardiac and cerebral mitochondrial dysfunction is similar after shockable vs nonshockable cardiac arrest in rabbits. Anesthetized rabbits were submitted to 10 min of no-flow by ventricular fibrillation (VF group) or asphyxia (non-shockable group). Read More

Eur J Gen Pract 2021 Dec;27(1):83-89

Scientific Centre for Quality of Healthcare (IQ healthcare), Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background: Signs of the systemic inflammatory response syndrome (SIRS) - fever (or hypothermia), tachycardia and tachypnoea - are used in the hospital setting to identify patients with possible sepsis.

Objectives: To determine how frequently abnormalities in the vital signs of SIRS are present in adult out-of-hours (OOH) primary care patients with suspected infections and assess the association with acute hospital referral.

Methods: We conducted a cross-sectional study at the OOH GP cooperative in Nijmegen, the Netherlands, between August and October 2015. Read More

Ther Hypothermia Temp Manag 2021 May 11. Epub 2021 May 11.

Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

We aimed to elucidate gaps in the provision of cognitive and psychological resources in cardiac arrest survivors. We conducted an online survey study between October 29, 2019, and November 15, 2019 with cardiac arrest survivors and caregiver members of the Sudden Cardiac Arrest Foundation. We queried survivors as to whether they experienced cognitive or psychological symptoms since their cardiac arrest. Read More

Acta Cir Bras 2021 7;36(3):e360307. Epub 2021 May 7.

PhD. Department of Spine Surgery - Guizhou Orthopedic Hospital - Guizhou Province, China.

Purpose: To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI).

Methods: Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's method to injure the spinal cord (T10) in rats, and then treated it with MH or/and rutin immediately. Read More

Nat Commun 2021 May 11;12(1):2648. Epub 2021 May 11.

National Institute of Biological Sciences (NIBS), Beijing, China.

The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1 mice show diminished 2MT-evoked c-fos expression in the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) and nucleus of the solitary tract (NTS). Read More

Int J Sports Physiol Perform 2021 May 11:1-8. Epub 2021 May 11.

Purpose: To measure core temperature (Tcore) in open-water (OW) swimmers during a 25-km competition and identify the predictors of Tcore drop and hypothermia-related dropouts.

Methods: Twenty-four national- and international-level OW swimmers participated in the study. Participants completed a personal questionnaire and a body fat/muscle mass assessment before the race. Read More

Eur J Neurol 2021 May 11. Epub 2021 May 11.

Department of Neurology, Dresden Neurovascular Center, Technische Universität Dresden, Dresden, Germany.

Background And Purpose: Hypothermia may be neuroprotective in acute ischemic stroke. Patients with anterior circulation large vessel occlusion (acLVO) are frequently hypothermic after endovascular therapy (EVT). We sought to determine whether this inadvertent hypothermia is associated with improved outcome. Read More

Neurosci Lett 2021 May 7:135940. Epub 2021 May 7.

Department of Anesthesiology, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. Electronic address:

Mitochondrial dysfunction is now considered an important sign of neuronal death during cerebral ischemia/reperfusion (I/R) injury. Studies have shown that the transfer of mitochondria from astrocytes to injured neurons contributes to endogenous neuroprotection after stroke. Basic and clinical studies have shown that mild hypothermia exerts a clear protective effect on neurons after cerebral ischemic injury, but the role of mild hypothermia in this endogenous neuroprotective mechanism remains unclear. Read More

Cryo Letters 2021 May-Jun;42(3):120-128

Institute of Biothermal Science and Technology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Worldwide women are increasingly facing the issue of delayed child-bearing and fertility decline. Oocyte cryopreservation provides an option for fertility preservation, especially for women with diseases and other special needs to conceive babies later. In this review we examine the effect of oocyte cryopreservation on early development of human embryos. Read More

Cureus 2021 Apr 5;13(4):e14305. Epub 2021 Apr 5.

Cardiology, Sanger Heart & Vascular Institute, Charlotte, USA.

Introduction: An underlying cardiomyopathy should be suspected in young patients presenting with ventricular arrhythmias and sudden cardiac arrest. Electrocardiograms revealing epsilon waves are associated with many serious conditions such as arrhythmogenic right ventricular cardiomyopathy, posterior myocardial infarction, right ventricular infarction, infiltration disease, sarcoidosis, Brugada Syndrome, Tetralogy of Fallot, and hypothermia. This case report features epsilon waves in a young cardiac arrest patient suspected of having an unrecognized cardiomyopathy that resulted in a fatal arrhythmia in the setting of exogenous bovine thyroid hormone and steroid use. Read More

Exp Ther Med 2021 Jun 15;21(6):626. Epub 2021 Apr 15.

Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.

Hypothermic treatment is known to protect against cardiac arrest (CA) and improve survival rate. However, few studies have evaluated the CA-induced liver damage and the effects of hypothermia on this damage. Therefore, the aim of the present study was to determine possible protective effects of hypothermia on the liver after asphyxial CA. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Apr;46(4):345-350

Drug Safety Evaluation Center of China Institute for Radiation Protection; Shanxi Key Laboratory of Drug Toxicology and Drug for Radiation Injury; Key Laboratory on Radiotoxicology and Radiopharmaceutical Preclinical Evaluation, China National Nuclear Corporation, Taiyuan 030006, China.

Objectives: To analyze the differentially expressed genes (DEGs) with radiation-induced rat lung injury, and to reveal the protective mechanism for mild hypothermia in the radiation-induced lung injury in rats at the transcriptome level.

Methods: A total of 10 male SD rats aged 6-8 weeks were randomly divided into 2 groups to establish a rat model of radiation-induced lung injury, and one group was treated with mild hypothermia. RNA was extracted from left lung tissue of each group, and sequenced by BGISEQ-500 platform. Read More

Adv Exp Med Biol 2021 ;1269:31-38

Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability. Therapeutic hypothermia (TH) is the only available standard of treatment, but 45-55% of cases still result in death or neurodevelopmental disability following TH. This work has focussed on developing a new brain tissue physiology and biochemistry systems biology model that includes temperature effects, as well as a Bayesian framework for analysis of model parameter estimation. Read More

Pediatr Res 2021 May 8. Epub 2021 May 8.

Department of Pediatrics, Wayne State University, Detroit, MI, USA.

Background: Better biomarkers of eventual outcome are needed for neonatal encephalopathy. To identify the most potent neonatal imaging marker associated with 2-year outcomes, we retrospectively performed diffusion-weighted imaging connectome (DWIC) and fixel-based analysis (FBA) on magnetic resonance imaging (MRI) obtained in the first 4 weeks of life in term neonatal encephalopathy newborns.

Methods: Diffusion tractography was available in 15 out of 24 babies with MRI, five each with normal, abnormal motor outcome, or death. Read More

Resuscitation 2021 May 5. Epub 2021 May 5.

Department of Emergency Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Purpose: We analysed the prognostic value of somatosensory, brainstem auditory and visual evoked potentials (SSEPs, BAEPs and VEPs, respectively) for outcome prediction in cardiac arrest patients with targeted temperature management (TTM) and assessed whether BAEP and VEP measurements conferred added value to SSEP measurements.

Methods: Cases with SSEPs and VEPs or BAEPs were reviewed in a TTM registry. We focused on whether the following responses were clearly discernible: N20 for SSEPs, V for BAEPs, and P100 for VEPs. Read More

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira. Electronic address:

Neonatal hypoxic-ischemic encephalopathy (nHIE) is a major neonatal brain injury. Despite therapeutic hypothermia, mortality and sequelae remain severe. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was associated with the pathophysiology of nHIE. Read More

Eur J Cardiothorac Surg 2021 May 8. Epub 2021 May 8.

South Tees Hospitals NHS Trust, Middlesbrough, UK.

Objectives: The risk of brain injury following surgery for type A aortic dissection (TAAD) remains substantial and no consensus has still been reached on which neuroprotective technique should be preferred. We aimed to investigate the association between neuroprotective strategies and clinical outcomes following TAAD repair.

Methods: Using the UK National Adult Cardiac Surgical Audit, we identified 1929 patients undergoing surgery for TAAD (2011-2018). Read More

Arch Dis Child Fetal Neonatal Ed 2021 May 7. Epub 2021 May 7.

Department of Neonatology, The National Maternity Hospital, Dublin, Ireland

We measured temperature on admission to the neonatal unit in a cohort of 54 very preterm infants. We measured rectal temperature with a digital thermometer (Microlife MT-1931) as the gold standard (MT-R). We also measured axillary temperature with the MT (MT-A), with the Welch Allyn SureTemp Plus 692 in 'continuous' (WAC) mode and in the default 'predictive' (WAP) mode. Read More

Pediatr Res 2021 May 5. Epub 2021 May 5.

Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.

Background: Infants with moderate and severe neonatal encephalopathy (NE) frequently suffer from long-term adverse outcomes. We hypothesize that the urinary metabolome of newborns with NE reflects the evolution of injury patterns observed with magnetic resonance imaging (MRI).

Methods: Eligible patients were newborn infants with perinatal asphyxia evolving to NE and qualifying for therapeutic hypothermia (TH) included in the HYPOTOP trial. Read More

Sci Rep 2021 May 5;11(1):9990. Epub 2021 May 5.

Department of Biochemistry and Molecular Biology and Research Institute "Hospital 12 de Octubre (imas12), Faculty of Biology, Complutense University, Jose Antonio Novais 12, Madrid, Spain.

Exp Anim 2021 Apr 29. Epub 2021 Apr 29.

Laboratory of Food Microbiology and Toxicology, College of Agriculture, Ibaraki University.

The mouse bioassay for diarrhetic shellfish poisoning (DSP) toxins had been used as the official method in Japan and also used in the world. In this study, hypothermia, one of the symptoms observed in mice after inoculation with DSP toxins, were characterized. Lethal and sublethal doses of okadaic acid (OA), a representative component of DSP toxins, were inoculated intraperitoneally into mice. Read More

Arch Dis Child Fetal Neonatal Ed 2021 May 5. Epub 2021 May 5.

Division of Neonatal-Perinatal Medicine, Dalhousie University-Faculty of Medicine, Halifax, Nova Scotia, Canada.

Background: Parenteral nutrition is commonly administered during therapeutic hypothermia. Randomised trials in critically ill children indicate that parenteral nutrition may be harmful.

Objective: To examine the association between parenteral nutrition during therapeutic hypothermia and clinically important outcomes. Read More

Arch Dis Child Fetal Neonatal Ed 2021 May 5. Epub 2021 May 5.

Centre for Perinatal Neuroscience, Brain Sciences Department, Imperial College of Science Technology and Medicine, London, UK.

We examined the association of Total Sarnat Score (TSS) with brain injury on neonatal magnetic resonance (MR) and adverse neurodevelopmental outcome (NDO) (death or moderate or severe disability) at 2 years of age in 145 infants undergoing therapeutic hypothermia for neonatal encephalopathy. TSS was associated with basal ganglia/thalamic injury on conventional MR (p=0.03) and thalamic N-acetyl aspartate on MR spectroscopy (R=0. Read More

J Trauma Nurs 2021 May-Jun 01;28(3):194-202

Abel Salazar Institute of Biomedical Sciences (Mr Mota) and CINTESIS-Center for Health Technology and Services Research (Dr M. R. Santos), University of Porto, Porto, Portugal; Superior Health School of Viseu, Viseu, Portugal (Mr Mota and Dr Cunha); UICISA: E/ESEnfC-Cluster at the Health School of Polytechnic Institute of Viseu, Viseu, Portugal (Mr Mota and Dr Cunha); Hospital Nossa Senhora da Assunção, Local Health Unit of Guarda, Seia, Portugal (Mr Mota); Nursing School of Porto, Porto, Portugal (Dr M. R. Santos); Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal (Dr E. J. F. Santos); Health Sciences Research Unit: Nursing, Nursing School of Coimbra, Coimbra. Portugal (Dr E. J. F. Santos); Polytechnic Institute of Viseu, Viseu, Portugal (Drs Henriques and Matos); Centre for Mathematics of the University of Coimbra (CMUC), Coimbra, Portugal (Dr Henriques); and Research Centre in Digital Services (CISeD), Viseu, Portugal (Dr Matos).

Background: Hypothermia in trauma patients causes increased morbidity and mortality. Swift recognition and treatment are important to prevent any further heat loss. In addition, patient discomfort from cold decreases satisfaction with care. Read More

J Clin Transl Sci 2020 Nov 16;5(1):e59. Epub 2020 Nov 16.

Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

Introduction: Identifying predictors of patient outcomes evaluated over time may require modeling interactions among variables while addressing within-subject correlation. Generalized linear mixed models (GLMMs) and generalized estimating equations (GEEs) address within-subject correlation, but identifying interactions can be difficult if not hypothesized . We evaluate the performance of several variable selection approaches for clustered binary outcomes to provide guidance for choosing between the methods. Read More

Pediatr Res 2021 May 4. Epub 2021 May 4.

Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Cerebral autoregulation mechanisms help maintain adequate cerebral blood flow (CBF) despite changes in cerebral perfusion pressure. Impairment of cerebral autoregulation, during and after cardiopulmonary bypass (CPB), may increase risk of neurologic injury in neonates undergoing surgery. In this study, alterations of cerebral autoregulation were assessed in a neonatal swine model probing four perfusion strategies. Read More