10,789 results match your criteria Hypopituitarism


Daily Sodium Monitoring and Fluid Intake Protocol: Preventing Recurrent Hospitalization in Adipsic Diabetes Insipidus.

J Endocr Soc 2019 May 18;3(5):882-886. Epub 2019 Mar 18.

Division of Endocrinology, Diabetes and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Management of diabetes insipidus (DI) is usually facilitated by an intact thirst mechanism prompting water ingestion in times of rising osmolality. Maintenance of eunatremia can be quite difficult in patients with DI and adipsia because of the absence of this homeostatic mechanism. Few published protocols for management of these complex cases exist. Read More

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http://dx.doi.org/10.1210/js.2018-00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467390PMC

MANAGEMENT AND OUTCOMES OF GIANT PROLACTINOMA: A SERIES OF 71 PATIENTS.

Endocr Pract 2019 Apr;25(4):340-352

To describe outcomes of patients with giant prolactinoma (≥4 cm) and identify predictors of therapeutic response. In this retrospective study, complete biochemical and structural response were defined as prolactin (PRL) ≤25 ng/mL and no visible tumor at follow-up, respectively. Giant prolactinoma (median size, 4. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0392
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http://dx.doi.org/10.4158/EP-2018-0392DOI Listing
April 2019
2 Reads

Identification of a Novel PROP1 Mutation in a Patient with Combined Pituitary Hormone Deficiency and Enlarged Pituitary.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.

Growth hormone deficiency (GHD) can be present from the neonatal period to adulthood and can be the result of congenital or acquired insults. In addition, GHD can be classified into two types: isolated growth hormone deficiency (IGHD) and combined pituitary hormone deficiency (CPHD). CPHD is a disorder characterized by impaired production of two or more anterior and/or posterior pituitary hormones. Read More

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http://dx.doi.org/10.3390/ijms20081875DOI Listing
April 2019
1 Read

Osteogenesis Imperfecta Due to Combined Heterozygous Mutations in Both and , Coexisting With Pituitary Stalk Interruption Syndrome.

Front Endocrinol (Lausanne) 2019 28;10:193. Epub 2019 Mar 28.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.

Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder, characterized by reduced bone content, fractures and skeletal malformation due to abnormal synthesis or dysfunction of type I collagen protein. Pituitary stalk interruption syndrome (PSIS) is usually associated with environmental and hereditary factors. Here, we report a rare case of OI and PSIS co-occurrence. Read More

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http://dx.doi.org/10.3389/fendo.2019.00193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447649PMC
March 2019
2 Reads

Radiation dose to neuroanatomical structures of pituitary adenomas and the effect of Gamma Knife radiosurgery on pituitary function.

J Neurosurg 2019 Apr 12:1-8. Epub 2019 Apr 12.

Departments of1Neurosurgery.

OBJECTIVEGamma Knife radiosurgery (GKRS) provides a safe and effective management option for patients with all types of pituitary adenomas. The long-term adverse effects of targeted radiation to the hypothalamic-pituitary axis in relationship to radiation dose remain unclear. In this retrospective review, the authors investigated the role of differential radiation doses in predicting long-term clinical outcomes and pituitary function after GKRS for pituitary adenomas. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182296DOI Listing

Hypopituitarism after Orthohantavirus Infection: What is Currently Known?

Viruses 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of Viroscience, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

Several case reports have described hypopituitarism following orthohantavirus infection, mostly following Puumala virus. The pathogenesis of this seemingly rare complication of orthohantavirus infection remains unknown. This review explores the possible pathophysiological mechanisms of pituitary damage due to orthohantavirus infection. Read More

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http://dx.doi.org/10.3390/v11040340DOI Listing

Osteonecrosis of Femoral Head is Associated with Congenital Multiple Pituitary Hormone Deficiency: Report of Three Cases and Literature Review.

Endocr Res 2019 Apr 10:1-6. Epub 2019 Apr 10.

a Department of Endocrinology , Peking Union Medical College Hospital, Key Laboratory of Endocrinology, Ministry of Health , Beijing , China.

Objective: Pituitary hormones are critical for bone development and maturation. It is currently unknown whether congenital multiple pituitary hormone deficiency (CMPHD) is associated with osteonecrosis of femoral head (ONFH).

Methods: Clinical presentations and hormonal profiles of three patients with CMPHD and ONFH were retrospectively described. Read More

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http://dx.doi.org/10.1080/07435800.2019.1601212DOI Listing
April 2019
1 Read
1.409 Impact Factor

Genetic diagnosis of congenital hypopituitarism by a target gene panel: novel pathogenic variants in GLI2, OTX2 and GHRHR.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

I Arnhold, Unidade de Endocrinologia do desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil.

Aim: Congenital hypopituitarism has an incidence of 1: 3,500 to 10,000 births and is defined by the impaired production of pituitary hormones. Early diagnosis has an impact on management and genetic counseling. The clinical and genetic heterogeneity of hypopituitarism poses difficulties to select the order of genes to analyse. Read More

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http://dx.doi.org/10.1530/EC-19-0085DOI Listing
April 2019
1 Read

Risk Factors for Anterior Hypopituitarism in Patients With Traumatic Brain Injury.

J Craniofac Surg 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurosurgery.

Background: Hypopituitarism is a common but potentially undiagnosed complication in patients who suffer traumatic brain injury (TBI). The identification of risk factors of hypopituitarism after TBI is vital to establish a rational testing approach for these patients.

Methods: The authors retrospectively reviewed the case records of patients with TBI, who underwent pituitary function evaluation in our department between January 2014 and December 2016. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005405DOI Listing
April 2019
5 Reads
0.676 Impact Factor

Intraoperative MRI in transsphenoidal resection of invasive pituitary macroadenomas.

Neurosurg Rev 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, University of Ulm, Ludwig-Heilmeyerstr. 2, 89312, Günzburg, Germany.

The use of intraoperative MRI (iMRI) increases extent of resection in transsphenoidal pituitary surgery. Microsurgical and endoscopic techniques have been established as equal and standard surgical methods. The object of the current study was to evaluate the additional value of iMRI for resection of invasive pituitary adenomas. Read More

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http://dx.doi.org/10.1007/s10143-019-01102-7DOI Listing
April 2019
1 Read

Abnormal thyroid function in paediatric practice.

Arch Dis Child Educ Pract Ed 2019 Apr 4. Epub 2019 Apr 4.

Department of Paediatric Endocrinology, KK Women's and Children's Hospital, Singapore, Singapore.

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31642
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http://dx.doi.org/10.1136/archdischild-2018-316426DOI Listing
April 2019
6 Reads

Anterior hypopituitarism secondary to biopsy-proven IgG4-related hypophysitis in a young man.

Endocrinol Diabetes Metab Case Rep 2019 Apr 3;2019. Epub 2019 Apr 3.

Department of Endocrinology, Peterborough City Hospital, Peterborough, UK.

IgG4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition which can affect various organs including the pituitary gland. The true annual incidence of this condition remains widely unknown. In addition, it is unclear whether IgG4 antibodies are causative or the end result of a trigger. Read More

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http://dx.doi.org/10.1530/EDM-18-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454222PMC
April 2019
3 Reads

Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study.

Front Endocrinol (Lausanne) 2019 19;10:149. Epub 2019 Mar 19.

Department of Pediatrics, University Medical Center, Amiens, France.

The aim of this study was to evaluate the frequency of hypopituitarism following TBI in a cohort of children who had been hospitalized for mild TBI and to identify the predictive factors for this deficiency. A prospective study was conducted on children between 2 and 16 years of age who had been hospitalized for mild TBI according to the Glasgow Coma Scale between September 2009 and June 2013. Clinical parameters, basal pituitary hormone assessment at 0, 6, and 12 months, as well as a dynamic testing (insulin tolerance test) 12 months after TBI were performed. Read More

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http://dx.doi.org/10.3389/fendo.2019.00149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433821PMC

Long-term Effects of Snake Envenoming.

Toxins (Basel) 2019 Mar 31;11(4). Epub 2019 Mar 31.

South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka.

Long-term effects of envenoming compromise the quality of life of the survivors of snakebite. We searched MEDLINE (from 1946) and EMBASE (from 1947) until October 2018 for clinical literature on the long-term effects of snake envenoming using different combinations of search terms. We classified conditions that last or appear more than six weeks following envenoming as long term or delayed effects of envenoming. Read More

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http://dx.doi.org/10.3390/toxins11040193DOI Listing
March 2019
3 Reads

Hypopituitarism post traumatic brain injury (TBI): review.

Ir J Med Sci 2019 Apr 1. Epub 2019 Apr 1.

Academic Department of Endocrinology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

Post-traumatic hypopituitarism (PTHP) is an important and relatively common complication of TBI (traumatic brain injury). A number of studies have shown that this clinical phenomenon can occur soon after TBI (acute) or later in the chronic phase. Patients with moderate to severe TBI are at a particular risk of developing PTHP. Read More

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http://link.springer.com/10.1007/s11845-019-02007-6
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http://dx.doi.org/10.1007/s11845-019-02007-6DOI Listing
April 2019
5 Reads

Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae.

Pituitary 2019 Mar 30. Epub 2019 Mar 30.

Medical Faculty, University of Belgrade, Dr Subotica 8, Belgrade, 11000, Serbia.

Traumatic brain injury (TBI) causes substantial neurological disabilities and mental distress. Annual TBI incidence is in magnitude of millions, making it a global health challenge. Categorization of TBI into severe, moderate and mild by scores on the Glasgow coma scale (GCS) is based on clinical grounds and standard brain imaging (CT). Read More

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http://dx.doi.org/10.1007/s11102-019-00957-9DOI Listing
March 2019
2 Reads
2.222 Impact Factor

Clinical picture and the treatment of TBI-induced hypopituitarism.

Pituitary 2019 Mar 30. Epub 2019 Mar 30.

Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy.

Traumatic brain injury (TBI) is an important public health problem with an increasing incidence in the last years. Relatively few cases are fatal; most individuals will survive and, in the long-term, the sequalae of TBI will include neuroendocrine dysfunctions with a much higher frequency than previously suspected. Patients who develop hypopituitarism after TBI present manifestations due to the number of deficient hormones, severity of hormonal deficiency, and the duration of hypopituitarism without diagnosis and treatment. Read More

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http://dx.doi.org/10.1007/s11102-019-00956-wDOI Listing
March 2019
2 Reads

Hydranencephaly complicated by central diabetes insipidus: report of two cases and systematic review of literature.

Childs Nerv Syst 2019 Mar 30. Epub 2019 Mar 30.

Section of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Ermita, 1000, Manila, Philippines.

Purpose: Hydranencephaly is a congenital condition characterized by the complete or near-complete absence of the cerebral cortex and basal ganglia, while central diabetes insipidus (CDI) is a condition characterized by the inability to concentrate urine due to a deficiency in antidiuretic hormone (ADH). CDI is known to occur in midline congenital malformations such as holoprosencephaly and septo-optic dysplasia, but its association with hydranencephaly is less well-established.

Methods: We reported two cases of hydranencephaly complicated by CDI. Read More

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http://dx.doi.org/10.1007/s00381-019-04137-9DOI Listing
March 2019
2 Reads

Pituitary pathology in traumatic brain injury: a review.

Pituitary 2019 Mar 29. Epub 2019 Mar 29.

Department of Laboratory Medicine, Division of Pathology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Purpose: Traumatic brain injury most commonly affects young adults under the age of 35 and frequently results in reduced quality of life, disability, and death. In long-term survivors, hypopituitarism is a common complication.

Results: Pituitary dysfunction occurs in approximately 20-40% of patients diagnosed with moderate and severe traumatic brain injury giving rise to growth hormone deficiency, hypogonadism, hypothyroidism, hypocortisolism, and central diabetes insipidus. Read More

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http://dx.doi.org/10.1007/s11102-019-00958-8DOI Listing
March 2019
1 Read
2.222 Impact Factor

Toxicities with Immune Checkpoint Inhibitors: Emerging Priorities From Disproportionality Analysis of the FDA Adverse Event Reporting System.

Target Oncol 2019 Apr;14(2):205-221

Pharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy.

Background: Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte associated protein 4 (CTLA4) and programmed cell death 1 or its ligand (PD1/PDL1), elicit different immune-related adverse events (irAEs), but their global safety is incompletely characterized.

Objective: The aim of this study was to characterize the spectrum, frequency, and clinical features of ICI-related adverse events (AEs) reported to the FDA Adverse Event Reporting System (FAERS).

Patients And Methods: AEs from FAERS (up to June 2018) recording ICIs (ipilimumab, nivolumab, pembrolizumab, atezolizumab, avelumab, durvalumab) as suspect were extracted. Read More

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http://dx.doi.org/10.1007/s11523-019-00632-wDOI Listing
April 2019
1 Read

Health and Lifestyle of Adult Patients with Congenital Isolated Growth Hormone Deficiency Treated in Childhood.

Isr Med Assoc J 2019 Mar;21(3):189-193

Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Petah Tikva.

Background: Treatment of patients with childhood growth hormone deficiency is usually terminated at the end of puberty. Follow-up into adult age is rare, even more so in patients with congenital isolated growth hormone deficiency (cIGHD).

Objectives: To assess the clinical and social characteristics of adults with cIGHD who received growth hormone (hGH) treatment in childhood. Read More

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March 2019
1 Read

Factors Predicting Time to TSH Normalization and Persistence of TSH Suppression After Total Thyroidectomy for Graves' Disease.

Front Endocrinol (Lausanne) 2019 1;10:95. Epub 2019 Mar 1.

Department of Endocrinology, Università Cattolica del Sacro Cuore, Rome, Italy.

Hyperthyroidism related to Graves' disease is associated with a suppression of TSH values which may persist after surgery in spite of a LT replacement therapy at non-TSH-suppressing doses. The aim of this retrospective study was to evaluate the time to TSH normalization in a group of patients who underwent total thyroidectomy for Graves' disease receiving a LT therapy dose regimen based on a previously published nomogram, and to identify possible correlations between the time to normalization of post-operative TSH values and preoperative clinical and biochemical parameters. 276 patients affected by Graves' disease who underwent surgery between 2010 and 2015, were retrospectively evaluated for clinical and biochemical parameters as well as post-surgical LT4 treatment regimen. Read More

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http://dx.doi.org/10.3389/fendo.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405427PMC
March 2019
1 Read

Clinical Characteristics and Postoperative Recovery of Hypopituitarism in Patients with Nonfunctional Pituitary Adenoma.

World Neurosurg 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, China; China Pituitary Disease Registry Center, Chinese Pituitary Adenoma Cooperative Group, Beijing, China; Key Laboratory of Endocrinology of National Health and Family Planning Commission, Beijing, China. Electronic address:

Objective: To investigate the clinical characteristics of hypopituitarism and its reversibility after surgery for nonfunctional pituitary adenoma (NFPA); analyze the correlation between tumor size and hypopituitarism incidence; and predict hypopituitarism by tumor volume and maximum diameter.

Methods: We retrospectively reviewed 164 patients with NFPA who underwent surgical treatment at Peking Union Medical College Hospital from January 2016 to December 2016. Demographic, imaging, and endocrine data were collected during preoperative, postoperative, and long-term follow-up (21. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.062DOI Listing
March 2019
2 Reads

Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation.

EBioMedicine 2019 Mar 13. Epub 2019 Mar 13.

Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom. Electronic address:

Background: The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encoding the eIF2γ subunit, are associated with severe intellectual disability and microcephaly, usually as part of MEHMO syndrome.

Methods: Exome sequencing of the X chromosome was performed on three related males with normal head circumferences and mild learning difficulties, hypopituitarism (GH and TSH deficiencies), and an unusual form of glucose dysregulation. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.013DOI Listing
March 2019
1 Read

A rare cause of postpartum acute hyponatremia.

Endocrinol Diabetes Metab Case Rep 2019 Mar 15;2019. Epub 2019 Mar 15.

Department of Internal Medicine F, Soroka University Medical Center, Beer Sheva, Israel.

A previously healthy 24-year-old female underwent an emergent caesarean section without a major bleeding described. During the first post-operative days (POD) she complained of fatigue, headache and a failure to lactate with no specific and conclusive findings on head CT. On the following days, fever rose with a suspicion of an obstetric surgery-related infection, again with no evidence to support the diagnosis. Read More

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http://dx.doi.org/10.1530/EDM-18-0124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432973PMC
March 2019
3 Reads

Hypothalamic-pituitary axis irradiation dose thresholds for the development of hypopituitarism in adult-onset gliomas.

Clin Endocrinol (Oxf) 2019 Mar 15. Epub 2019 Mar 15.

Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: Childhood brain tumour survivors who receive cranial radiotherapy undergo regular surveillance for the development ofhypothalamic-pituitary (HP) axis dysfunction. Much less attention has been given to radiation-induced hypopituitarism in patients with malignant brain tumours of adult onset.

Design: Retrospective cohort study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13971
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http://dx.doi.org/10.1111/cen.13971DOI Listing
March 2019
9 Reads

Entirely Suprasellar Rathke Cleft Cysts: Clinical Features and Surgical Efficacy of Endoscopic Endonasal Transtuberculum Sellae Approach.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Rathke cleft cysts (RCCs) arise from the remnant of Rathke pouch and are usually found in the intermediate lobe. In most cases, RCCs remain intrasellar and extend into the suprasellar region. Rarely, they emerge entirely into the suprasellar cistern-entirely suprasellar Rathke cleft cyst (ESSRCC). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.011DOI Listing
March 2019
2 Reads

PITUITARY STALK THICKENING IN A LARGE COHORT - TOWARDS MORE ACCURATE PREDICATORS OF PITUITARY DYSFUNCTION AND ETIOLOGY.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China. 200025.

Objective: To summarize the characteristics of patients with pituitary stalk thickening, analyze the association between pituitary stalk width and hypopituitarism, and develop a diagnostic model to differentiate neoplastic and inflammatory origins.

Methods: 325 patients with pituitary stalk thickening in a tertiary teaching hospital between January 2012 and February 2018 were enrolled. Basic characteristics and hormonal status were evaluated. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0550
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http://dx.doi.org/10.4158/EP-2018-0550DOI Listing
March 2019
6 Reads
2.811 Impact Factor

EVALUATION OF TREATMENT OF CENTRAL HYPOTHYROIDISM VERSUS PRIMARY HYPOTHYROIDISM IN RELATION TO LEVOTHYROXINE REPLACEMENT DOSE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Graduate Program in Pathology, Universidade Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Brazil.

Objective: The aim of this study was to evaluate levothyroxine (LT4) replacement daily doses, considered clinical and biochemical appropriate, in patients with Central Hypothyroidism (CeH) and compare them with those adequate for patients with Primary Hypothyroidism (P-HYPO).

Methods: We included 53 patients with CeH and 57 with PH, matched by sex, age, weight and body mass index, followed in a Neuroendocrine Referral Center, in the period of one year. At the time of inclusion, all presented a stable and adequate dose of LT4 for at least three months, considering as adequate the dose associated with normal TSH levels and free T4 in P-HYPO patients, and free T4 levels in CeH patients. Read More

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http://dx.doi.org/10.4158/EP-2018-0533DOI Listing
March 2019
4 Reads

Primary tumors of the posterior pituitary: A systematic review.

Rev Endocr Metab Disord 2019 Mar 12. Epub 2019 Mar 12.

Department of Endocrinology, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

In 2017, the World Health Organization established that pituicytoma, granular cell tumor (GCT), spindle cell oncocytoma (SCO) and sellar ependymomas (SE) are posterior pituitary tumors (PPT). They probably arise from the pituicytes and may constitute a unique histopathological entity. We carried out a systematic review using PubMed's database. Read More

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http://dx.doi.org/10.1007/s11154-019-09484-1DOI Listing
March 2019
13 Reads

Hypopituitarism Related Cholestatic Jaundice: Important to Recognise, Rewarding to Treat but Difficult to Diagnose!

Indian J Pediatr 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatric Gastroenterology, SGPGIMS, Raebareli Road, Lucknow, UP, India.

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http://dx.doi.org/10.1007/s12098-019-02922-7DOI Listing

Rare empty sella syndrome found after postoperative hypotension and respiratory failure: A case report.

World J Clin Cases 2019 Mar;7(5):663-667

Department of Anesthesiology, Shaoxing Central Hospital, Shaoxing 312000, Zhejiang Province, China.

Background: Empty sella syndrome is a condition in which the pituitary gland shrinks or flattens. Patients with empty sella syndrome often present with headache, hypertension, obesity, visual disturbances, cerebrospinal fluid (CSF) rhinorrhoea, or endocrine dysfunction. Herein, we report a rare case of empty sella syndrome discovered after the patient experienced postoperative hypotension and respiratory failure. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i5.663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406202PMC
March 2019
1 Read

Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer.

BMJ Case Rep 2019 Mar 7;12(3). Epub 2019 Mar 7.

Hematology/Oncology, University of Southern California-Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, USA.

We describe the clinical course of a 64-year-old woman with stage IVa lung adenocarcinoma who presented with over 1 month of fatigue, unintentional weight loss and emesis. She initiated treatment with nivolumab immunotherapy 1 year prior and had been tolerating the treatment well. A comprehensive workup revealed multiple endocrinological abnormalities consistent with hypophysitis leading to hypopituitarism in the form of central adrenal insufficiency and hypogonadism as well as a partially empty sella on imaging. Read More

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http://dx.doi.org/10.1136/bcr-2018-228135DOI Listing
March 2019
2 Reads

The role of autoimmunity in pituitary dysfunction due to traumatic brain injury.

Pituitary 2019 Mar 7. Epub 2019 Mar 7.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Purpose: Traumatic brain injury (TBI) is one of the most common causes of mortality and long-term disability and it is associated with an increased prevalence of neuroendocrine dysfunctions. Post-traumatic hypopituitarism (PTHP) results in major physical, psychological and social consequences leading to impaired quality of life. PTHP can occur at any time after traumatic event, evolving through various ways and degrees of deficit, requiring appropriate screening for early detection and treatment. Read More

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http://link.springer.com/10.1007/s11102-019-00953-z
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http://dx.doi.org/10.1007/s11102-019-00953-zDOI Listing
March 2019
5 Reads

Radiological and endocrinological evaluations with grading of hypothalamic perifocal edema caused by craniopharyngiomas.

Pituitary 2019 Apr;22(2):146-155

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Introduction: Hypophysial and hypothalamic dysfunction caused by craniopharyngioma is a serious problem despite the progress of surgical approaches and techniques. Perifocal edema induced by craniopharyngioma could be speculated as a potential factor resulting in pre- and post-operative hypophysial and hypothalamic dysfunction, as well as, their anatomical involvement.

Methods: Medical records of 54 patients with craniopharyngioma were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s11102-019-00945-zDOI Listing
April 2019
1 Read

Dissemination of brain inflammation in traumatic brain injury.

Cell Mol Immunol 2019 Mar 7. Epub 2019 Mar 7.

Departments of Neurology and Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Traumatic brain injury (TBI) is recognized as a global health problem due to its increasing occurrence, challenging treatment, and persistent impacts on brain pathophysiology. Neural cell death in patients with TBI swiftly causes inflammation in the injured brain areas, which is recognized as focal brain inflammation. Focal brain inflammation causes secondary brain injury by exacerbating brain edema and neuronal death, while also exerting divergent beneficial effects, such as sealing the damaged limitans and removing cellular debris. Read More

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http://dx.doi.org/10.1038/s41423-019-0213-5DOI Listing

Improvements in body composition after 4 years of growth hormone treatment in adult-onset hypopituitarism compared to age-matched controls.

Neuroendocrinology 2019 Mar 8. Epub 2019 Mar 8.


Background/aims: It is unknown whether long-term growth hormone replacement therapy (GHRT) affects body composition in an age- or sex dependent manner. We aimed to study the effects of 4 years of GHRT on body composition in a large cohort of patients with hypopituitarism compared to a reference population matched by age and sex.

Methods: A total of 964 GH deficient adults from KIMS (Pfizer International Metabolic Database) with adult-onset hypopituitarism, adequately replaced with all pituitary hormones except for GH at baseline were included. Read More

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http://dx.doi.org/10.1159/000499430DOI Listing
March 2019
1 Read

The real costs of acromegaly: analysis of different therapies.

Endokrynol Pol 2019 ;70(1):74-85

Deptartment of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Wroclaw, Poland.

Acromegaly is a rare, chronic condition caused by growth hormone (GH) overproduction, usually due to a benign tumour of the pituitary gland. During the disease many complications occur, including cardiovascular disease and changes in the musculoskeletal, respiratory, and endocrine systems. Treatment includes surgery, medical therapy, and radiation. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.a2018.0080DOI Listing
January 2019
6 Reads

Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions.

J Neurosurg 2019 Mar 1:1-5. Epub 2019 Mar 1.

1Department of Neurological Surgery and.

OBJECTIVEHypothalamic-pituitary-adrenal (HPA) axis dysfunction is a well-documented complication of transsphenoidal craniotomy (TSC) for sellar lesions. The authors aimed to assess their multidisciplinary approach to the diagnosis and treatment of postoperative hypocortisolemia utilizing conservative screening methods.METHODSThe authors performed a retrospective review of 257 patients who underwent TSC for pituitary adenoma (PA) or Rathke cleft cyst (RCC) at the University of Southern California between 2012 and 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182521DOI Listing
March 2019
4 Reads

The history of pituitary dysfunction after traumatic brain injury.

Pituitary 2019 Mar 2. Epub 2019 Mar 2.

Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy.

Purpose: To estimate the total number of articles on traumatic brain injury (TBI)-related hypopituitarism and patients (including children and adolescents) with such disorder that were published until now, particularly after the author's review published on April 2000.

Methods: Review of the literature retrievable on PubMed.

Results: TBI-related hypopituitarism accounts for 7. Read More

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http://dx.doi.org/10.1007/s11102-019-00949-9DOI Listing

Truncating RAX mutations: anophthalmia, hypopituitarism, diabetes insipidus and cleft palate in mice and men.

J Clin Endocrinol Metab 2019 Feb 27. Epub 2019 Feb 27.

Depts. of Biochemistry, Otolaryngology, Ophthalmology, and Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Context: The transcription factor RAX is a paired-type homeoprotein that plays a critical role in eye and forebrain development of vertebrate species. RAX knockout mice have anophthalmia, cleft palate, abnormal hypothalamus, and display perinatal lethality. In humans, homozygous or compound heterozygous RAX mutations are reported to cause bilateral micro/anophthalmia without consistent associated features. Read More

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http://dx.doi.org/10.1210/jc.2018-02316DOI Listing
February 2019
2 Reads

Safety and efficacy of multisession gamma knife radiosurgery for residual or recurrent pituitary adenomas.

Endocrine 2019 Feb 23. Epub 2019 Feb 23.

Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Purpose: To define the efficacy and complications of multisession Gamma Knife radiosurgery (MGKRS) delivered in three consecutive sessions for the treatment of residual or recurrent pituitary adenomas (PAs).

Methods: This was a retrospective study of data from the Neurosurgery and Gamma Knife Radiosurgery Department at San Raffaele Hospital between May 2008 and September 2017. We recruited 47 consecutive patients undergoing MGKRS in three consecutive fractions for residual or recurrent PA with a distance from the anterior optic pathway inferior to 2-3 mm. Read More

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http://dx.doi.org/10.1007/s12020-019-01876-2DOI Listing
February 2019
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Pituitary macroadenoma presenting as severe hyponatremia: a case report.

J Med Case Rep 2019 Feb 23;13(1):40. Epub 2019 Feb 23.

Department of Surgery, Teaching Hospital, Kandy, Sri Lanka.

Background: Hyponatremia is defined as a serum sodium level of less than 135 mEq/L in a patient. Although hyponatremia is not an uncommon laboratory finding, especially in the elderly, hunting for the etiology is a challenging issue for any clinician. The three first-line investigations that are required for further analysis are urine osmolality, serum osmolality, and urinary sodium levels in addition to clinical assessment of volume status. Read More

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http://dx.doi.org/10.1186/s13256-019-2000-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387537PMC
February 2019
2 Reads

Outcomes After Gamma Knife Stereotactic Radiosurgery in Pediatric Patients with Cushing Disease or Acromegaly: A Multi-Institutional Study.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA. Electronic address:

Objective: Pituitary adenomas comprise about 3% of all intracranial tumors in pediatric patients. This study examines the role of stereotactic radiosurgery in the management of pediatric acromegaly or patients with Cushing disease (CD).

Methods: From an international consortium, we retrospectively collected treatment and outcome data on pediatric adrenocorticotrophic hormone and growth hormone-secreting pituitary adenomas treated with Gamma Knife radiosurgery (GKRS). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.252DOI Listing
February 2019
6 Reads
2.417 Impact Factor

[Differential diagnosis and treatment of pituitary adenomas].

HNO 2019 Apr;67(4):307-318

Klinik für Neurochirurgie, Universität Ulm, Albert-Einstein-Allee 23, 89075, Ulm, Deutschland.

Pituitary adenomas are among the most common primary brain tumors. These tumors can produce all hormones of the anterior pituitary and thus cause endocrine diseases. Compression of the pituitary gland, the surrounding cranial nerves, or brain structures can lead to hypopituitarism, cranial nerve deficits, or diverse neurological symptoms. Read More

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http://dx.doi.org/10.1007/s00106-019-0629-3DOI Listing
April 2019
2 Reads

Expanding the genetic and clinical spectrum of the NONO-associated X-linked intellectual disability syndrome.

Am J Med Genet A 2019 May 17;179(5):792-796. Epub 2019 Feb 17.

Division of Medical Genetics, University of Utah, Salt Lake City, Utah.

The NONO gene encodes a nuclear protein involved in RNA metabolism. Hemizygous loss-of-function NONO variants have been associated with syndromic intellectual disability and with left ventricular noncompaction (LVNC). A two-year-old boy presented to the University of Utah's Penelope Undiagnosed Disease Program with developmental delay, nonfamilial features, relative macrocephaly, and dilated cardiomyopathy with LVNC and Ebstein anomaly. Read More

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http://dx.doi.org/10.1002/ajmg.a.61091DOI Listing
May 2019
4 Reads

Be aware of the effects of glucocorticoids on SIADH: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14295

Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Guangdong Province, China.

Rationale: Hyponatremia is one of the most common electrolyte disorders in clinic. Due to the complicated etiology and the nonspecific clinical manifestations, the diagnosis of hyponatremia is a complicated process. A variety of clinical disorders can cause inappropriately increased antidiuretic hormone (ADH) secretion, leading to inappropriate water retention and consequent hyponatremia. Read More

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http://dx.doi.org/10.1097/MD.0000000000014295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408106PMC
February 2019
10 Reads

Congenital Hypopituitarism: Various Genes, Various Phenotypes.

Horm Metab Res 2019 Feb 13;51(2):81-90. Epub 2019 Feb 13.

Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, "Aghia Sofia" Children's Hospital, Athens, Greece.

The ontogenesis and development of the pituitary gland is a highly complex process that depends on a cascade of transcription factors and signaling molecules. Spontaneous mutations and transgenic murine models have demonstrated a role for many of these factors, including , , , , , , , , , , , and in the etiology of congenital hypopituitarism. Genetic mutations in any of these factors can lead to congenital hypopituitarism, which is characterized by the deficiency in one or more pituitary hormones. Read More

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http://dx.doi.org/10.1055/a-0822-3637DOI Listing
February 2019
1 Read

Traumatic brain injury induced neuroendocrine changes: acute hormonal changes of anterior pituitary function.

Pituitary 2019 Feb 12. Epub 2019 Feb 12.

Department of Endocrinology and Diabetes, Evangelismos Hospital, Athens, Greece.

Purpose: It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterior pituitary hormonal changes in the acute post-TBI period and we present the evidence supporting the need for screening of anterior pituitary function in the early post-TBI time along with current suggestions regarding the endocrine assessment and management of these patients. Read More

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http://link.springer.com/10.1007/s11102-019-00944-0
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http://dx.doi.org/10.1007/s11102-019-00944-0DOI Listing
February 2019
11 Reads

[Hypopituitarism associated with autoimmune pancreatitis: a case report].

Nihon Shokakibyo Gakkai Zasshi 2019;116(2):168-176

Department of Gastroenterology, Faculty of Medicine, Yamagata University.

We herein report the case of a 64-year-old male patient with hypopituitarism associated with autoimmune pancreatitis (AIP). The patient was previously diagnosed with AIP based on the presence of a swollen pancreas, elevated serum immunoglobulin G4, and narrowing of the pancreatic duct by imaging. Magnetic resonance imaging revealed a pituitary stem tumor, and loading test showed a decrease in the function of the anterior lobe suggesting severe failure of growth hormone secretion. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.168DOI Listing
January 2019