10,714 results match your criteria Hypopituitarism


Congenital Hypopituitarism: Various Genes, Various Phenotypes.

Horm Metab Res 2019 Feb 13;51(2):81-90. Epub 2019 Feb 13.

Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, "Aghia Sofia" Children's Hospital, Athens, Greece.

The ontogenesis and development of the pituitary gland is a highly complex process that depends on a cascade of transcription factors and signaling molecules. Spontaneous mutations and transgenic murine models have demonstrated a role for many of these factors, including , , , , , , , , , , , and in the etiology of congenital hypopituitarism. Genetic mutations in any of these factors can lead to congenital hypopituitarism, which is characterized by the deficiency in one or more pituitary hormones. Read More

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http://dx.doi.org/10.1055/a-0822-3637DOI Listing
February 2019

Traumatic brain injury induced neuroendocrine changes: acute hormonal changes of anterior pituitary function.

Pituitary 2019 Feb 12. Epub 2019 Feb 12.

Department of Endocrinology and Diabetes, Evangelismos Hospital, Athens, Greece.

Purpose: It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterior pituitary hormonal changes in the acute post-TBI period and we present the evidence supporting the need for screening of anterior pituitary function in the early post-TBI time along with current suggestions regarding the endocrine assessment and management of these patients. Read More

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http://link.springer.com/10.1007/s11102-019-00944-0
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http://dx.doi.org/10.1007/s11102-019-00944-0DOI Listing
February 2019
1 Read

[Hypopituitarism associated with autoimmune pancreatitis: a case report].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):168-176

Department of Gastroenterology, Faculty of Medicine, Yamagata University.

We herein report the case of a 64-year-old male patient with hypopituitarism associated with autoimmune pancreatitis (AIP). The patient was previously diagnosed with AIP based on the presence of a swollen pancreas, elevated serum immunoglobulin G4, and narrowing of the pancreatic duct by imaging. Magnetic resonance imaging revealed a pituitary stem tumor, and loading test showed a decrease in the function of the anterior lobe suggesting severe failure of growth hormone secretion. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.168DOI Listing
January 2019

High prevalence of pituitary hormone deficiency in both unilateral and bilateral optic nerve hypoplasia.

Acta Paediatr 2019 Feb 11. Epub 2019 Feb 11.

Department of Women's and Children's Health, Neuropediatric Unit, Karolinska Institutet, Stockholm, Sweden.

Aim: This study examined the prevalence of neurological impairment and pituitary hormone deficiency (PHD) in patients with unilateral and bilateral optic nerve hypoplasia (ONH).

Methods: A population-based cross-sectional cohort study of 65 patients (51% female) with ONH was conducted in Stockholm. Of these were 35 bilateral and 30 unilateral. Read More

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http://dx.doi.org/10.1111/apa.14751DOI Listing
February 2019
1 Read

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
February 2019
7 Reads

Prolonged neonatal hyperbilirubinaemia in a case of congenital hypopituitarism.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh UT, India.

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http://dx.doi.org/10.1136/bcr-2018-228793DOI Listing
February 2019
3 Reads

Hypopituitarism following Cranial Irradiation for Meningiomas: A single-institution experience.

Pract Radiat Oncol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Patients undergoing cranial irradiation are at high risk for development of subsequent pituitary deficiencies. Patients with meningiomas can expect to live many years following treatment and are therefore particularly vulnerable to long-term sequalae of radiation therapy (RT). The purpose of this study was to determine the rates and timing of onset of pituitary dysfunction across each hypothalamic-pituitary axis in patients with meningiomas in the sellar region. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18798500193004
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http://dx.doi.org/10.1016/j.prro.2019.01.009DOI Listing
February 2019
2 Reads

CircOMA1 mediated miR-145-5p suppresses tumor growth of nonfunctioning pituitary adenomas by targeting TPT1.

J Clin Endocrinol Metab 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery and Pituitary Tumor Center. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Context: Nonfunctioning pituitary adenomas (NFPAs) are the major cause of hypopituitarism and infertility. However, the pathogenesis of NFPAs remains largely unknown. Previous studies have demonstrated the crucial role of microRNAs (miRNAs) in the progression of pituitary adenomas. Read More

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http://dx.doi.org/10.1210/jc.2018-01851DOI Listing
February 2019
1 Read

[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):105-113

Burdenko Neurosurgical Institute, Moscow, Russia.

The use of endoscopic technique has significantly extended the indications for surgery using the transsphenoidal approach. Currently, more than 90% of pituitary adenomas are operated on transsphenoidally. Transnasal removal of giant pituitary adenomas has become possible. Read More

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http://dx.doi.org/10.17116/neiro201882061105DOI Listing
January 2018
1 Read

[Clinical and functional characteristics of giant pituitary adenomas in the population of patients in the Moscow region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):76-81

Moscow Regional Researh and Clinical Institute, Moscow, Russia.

Benign pituitary tumors are the most common sellar neoplasms. Lesions larger than 39 mm in the maximum dimension are called giant. They are rare, and, therefore, there are few data on the clinical and morphological features of giant pituitary tumors with different hormonal activity. Read More

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http://dx.doi.org/10.17116/neiro20188206176DOI Listing
January 2018
1 Read

Rapidly Progressing Pituitary Mass in B-cell Lymphoma.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

The First Department of Medicine, Wakayama Medical University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.1576-18DOI Listing
February 2019

Exploring immunomodulation by endocrine changes in Lady Windermere Syndrome.

Clin Exp Immunol 2019 Jan 29. Epub 2019 Jan 29.

Faculty of Medicine, the University of Queensland, Brisbane, Queensland, Australia.

Lung disease due to nontuberculous mycobacteria (NTM) occurs with disproportionate frequency in postmenopausal women with a unique phenotype and without clinically apparent predisposing factors. Dubbed "Lady Windermere Syndrome", the phenotype includes low body mass index (BMI), tall stature, and higher than normal prevalence of scoliosis, pectus excavatum and mitral valve prolapse. Although the pathomechanism for susceptibility to NTM lung disease in these patients remains uncertain, it is likely to be multifactorial. Read More

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http://dx.doi.org/10.1111/cei.13265DOI Listing
January 2019
1 Read

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports.

Clin Diabetes Endocrinol 2019 22;5. Epub 2019 Jan 22.

1Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.

Background: Since 2011 six immune checkpoint inhibitors (ICI) have been approved to treat patients with many advanced solid tumor and hematological malignancies to improve their prognosis. Case reports of their endocrine immune-related adverse events [irAEs]) are increasingly published as more real-world patients with these malignancies are treated with these drugs. They alert physicians of a drug's AEs (which may change during a drug's life cycle) and contribute to post-marketing safety surveillance. Read More

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https://clindiabetesendo.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s40842-018-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343255PMC
January 2019
4 Reads

Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.

Pediatr Diabetes 2019 Jan 26. Epub 2019 Jan 26.

Pediatric Endocrine and Diabetes Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Objective: When diabetes is associated with congenital malformations, without autoimmune antibodies, a genetic cause is suspected. Here, we aimed to identify a defective gene that led to diabetes.

Research Design And Methods: We performed an exome analysis of an index case and his healthy parents. Read More

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http://doi.wiley.com/10.1111/pedi.12814
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http://dx.doi.org/10.1111/pedi.12814DOI Listing
January 2019
4 Reads

Pituitary incidentalomas in paediatric age are different from those described in adulthood.

Pituitary 2019 Jan 25. Epub 2019 Jan 25.

Faculty of Medicine of University of Porto, Porto, Portugal.

Purpose: Guidelines on pituitary incidentalomas evaluation and management are limited to adults since there are no data on this matter in the paediatric population. We aim to analyse the morphologic characteristics, hormonal profile and follow-up of these lesions in children.

Methods: We have searched for pituitary incidentalomas in the neuroimaging reports and electronic medical records of the Paediatric Endocrinology Clinic of our centre. Read More

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http://dx.doi.org/10.1007/s11102-019-00940-4DOI Listing
January 2019
3 Reads

The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.

Pituitary 2019 Jan 25. Epub 2019 Jan 25.

Academic Department of Endocrinology, Beaumont Hospital and the RCSI Medical School, Beaumont Road, Dublin 9, Ireland.

Purpose: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, debate still exists about the true prevalence of hypopituitarism after head injury.

Methods: We have reviewed the literature describing the frequency of post-traumatic hypopituitarism and discuss the factors which may explain the variable frequency of the reported deficits in clinical studies including research methodology and the natural history of the disease. Read More

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http://dx.doi.org/10.1007/s11102-019-00938-yDOI Listing
January 2019
1 Read

Liver Involvement in Congenital Hypopituitarism.

Indian J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatric Endocrinology, Uludag University Faculty of Medicine, Bursa, Turkey.

Objective: Cholestatic jaundice in early infancy is a complex diagnostic challenge. Cholestasis caused by endocrine disease is rare and poorly recognized. The aim of this paper is to report patients with liver dysfunctions resulting from hypopituitarism. Read More

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http://dx.doi.org/10.1007/s12098-018-2833-7DOI Listing
January 2019
2 Reads

Long-Term Follow-Up Studies of Gamma Knife Radiosurgery for Postsurgical Nonfunctioning Pituitary Adenomas.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Capital Medical University, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Key Laboratory of Central Nervous System Injury Research, Beijing, China. Electronic address:

Objective: The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery (GKRS) for residual and recurrent nonfunctioning pituitary adenomas (NFPAs) after surgery and the role of GKRS in the management of NFPAs.

Methods: Between January 2000 and December 2010, 204 patients with residual or recurrent NFPAs undergoing GKRS were enrolled in this study according to the inclusion criteria. The median age of the patients was 48 years (mean, 48 years; range, 14-79 years). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.009DOI Listing
January 2019

Oxytocin alterations and neurocognitive domains in patients with hypopituitarism.

Pituitary 2019 Jan 17. Epub 2019 Jan 17.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL, 60612, USA.

Purpose: Oxytocin is a hypothalamus derived, posterior pituitary stored nonapeptide which has gained recent interest as an important neuropsychiatric and metabolic hormone beyond its classic role in lactation and parturition. Hypopituitarism is a heterogenous disorder of derangement in one or more anterior or posterior pituitary hormones. Diagnosis of deficiency and hormone replacement exists to address all relevant axes except for oxytocin. Read More

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http://link.springer.com/10.1007/s11102-019-00936-0
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http://dx.doi.org/10.1007/s11102-019-00936-0DOI Listing
January 2019
9 Reads

The autoimmune basis of hypopituitarism in traumatic brain injury: fiction or reality?

Br J Neurosurg 2019 Jan 17:1-4. Epub 2019 Jan 17.

a Neurosurgery , Rajendra Institute of Medical Sciences , Ranchi , Jharkhand , India.

Post-traumatic hypopituitarism has remained as an obscured cause of worsening morbidity and mortality in head injury patients. Researchers have for decades been puzzled by the mechanism of pituitary dysfunction in these cases. Amongst other causes like direct injury, vascular injury etc, an immunological basis of hypopituitarism has been suggested in some animal studies as well as human research. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1485875DOI Listing
January 2019
6 Reads

Growth hormone replacement therapy improves hypopituitarism-associated hypoxemia in a patient after craniopharyngioma surgery: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14101

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China.

Rationale: There are some reports about hypoxemia related to hypopituitarism. However, little is known about the relationship between growth hormone deficiency (GHD) and hypoxemia.

Patients Concerns: A 23-year-old female presented with severe hypoxemia after the operations of craniopharyngioma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014101DOI Listing
January 2019
1 Read

Slipped capital femoral epiphysis in an adult with congenital hypopituitarism: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13997

Department of Orthopedic Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: Slipped capital femoral epiphysis (SCFE) is a common hip problem in adolescents, usually individuals between 8 and 15 years old. Because of the frequent finding of growth abnormalities in affected children, various endocrine disturbances have been reported as the cause of the disease. However, there are few case reports of older patients in previous literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013997DOI Listing
January 2019
6 Reads

Endocrinological outcomes of intraoperative MRI-guided endoscopic transsphenoidal surgery for non-functioning pituitary adenoma.

Turk Neurosurg 2018 Jun 27. Epub 2018 Jun 27.

Chinese PLA General Hospital.

Aim: The influence of intraoperative magnetic resonance imaging (iMRI) on endocrinological outcomes remains unclear. We aimed to assess the endocrinological outcomes of high-field (1.5-T) iMRI-guided endoscopic transsphenoidal surgery (TSS) for non-functioning pituitary adenomas (NFPAs). Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.22603-18.2DOI Listing
June 2018
1 Read

A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade.

Case Rep Endocrinol 2018 17;2018:1746917. Epub 2018 Dec 17.

Section of Medicine, Endocrinology, Department of Diabetes and Metabolism, San Juan City Hospital, San Juan, Puerto Rico, USA.

We report the case of a 34-year-old male Hispanic patient who presented with an 8-month history of polyuria and decreased libido. An evaluation revealed hypopituitarism, central diabetes insipidus, and a pituitary stalk lesion. No evidence of a neoplasm or an inflammatory/infiltrative disease was found. Read More

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http://dx.doi.org/10.1155/2018/1746917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311725PMC
December 2018
2 Reads

The Predictive Value of Insulin-Like Growth Factor 1 in Irradiation-Dependent Growth Hormone Deficiency in Childhood Cancer Survivors.

Horm Res Paediatr 2019 Jan 15:1-12. Epub 2019 Jan 15.

Department of Paediatric Endocrinology, Royal Marsden NHS Foundation Trust, London, United Kingdom.

Background: The literature contains conflicting reports on the value of low insulin-like growth factor 1 (IGF-1) levels in predicting radiation-induced growth hormone (GH) deficiency (GHD) in childhood cancer survivors (CCS). These reports often involve small samples of patients who have received irradiation or mixed cohorts including non-irradiated subjects.

Objective: We undertook an analysis of the predictive value of low IGF-1 in CCS at risk for GHD after cranial radiotherapy involving the hypothalamic-pituitary (HP) area in a large single-centre cohort. Read More

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http://dx.doi.org/10.1159/000495760DOI Listing
January 2019
1 Read

Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.

Pituitary 2019 Jan 14. Epub 2019 Jan 14.

Department of Endocrinology and Metabolism, Yeditepe University Medical School, Istanbul, Turkey.

Introduction: The prevalence of pituitary dysfunction is high following aneurysmal subarachnoid hemorrhage (aSAH) and when occurs it may contribute to residual symptoms of aSAH such as decreased cognition and quality of life. Hypopituitarism following aSAH may have non-specific, subtle symptoms and potentially serious consequences if remained undiagnosed.

Methods: We reviewed the literature on epidemiology, pathophysiology, diagnostic methods and management of neuroendocrine changes after aSAH as well as on the impact of pituitary dysfunction on outcome of the patient. Read More

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http://link.springer.com/10.1007/s11102-018-00932-w
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http://dx.doi.org/10.1007/s11102-018-00932-wDOI Listing
January 2019
4 Reads

Empirical versus progression-guided stereotactic radiosurgery for non-functional pituitary macroadenomas after subtotal resection.

J Neurooncol 2019 Jan 12. Epub 2019 Jan 12.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Objective: There is a lack of consensus regarding whether if residual non-functional macroadenomas (NFM) should undergo empirical stereotactic radiosurgery (SRS) or be monitored until tumor progression before SRS treatment. The aim of this study is to compare the risks and benefits of empirical versus progression-guided SRS for NFM after subtotal resection.

Methods: This is a retrospective study of consecutive NFM patients who subtotal surgical resection followed by SRS between 1999 and 2014. Read More

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http://dx.doi.org/10.1007/s11060-019-03095-1DOI Listing
January 2019
2 Reads

Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma.

J Korean Neurosurg Soc 2019 Jan 31;62(1):114-122. Epub 2018 Dec 31.

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Objective: Silent corticotroph adenomas (SCA) are endocrine-inactive pituitary adenomas with positive immunohistochemistry staining for adrenocorticotropic hormone (ACTH). We investigated whether SCA-associated clinical profiles were more aggressive than hormonally negative adenomas (HNA).

Methods: Among 627 patients with pathologically proven endocrine-inactive pituitary adenomas between 2004 and 2013, positive immunohistochemistry revealed 55 SCAs and 411 HNAs. Read More

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http://jkns.or.kr/journal/view.php?doi=10.3340/jkns.2018.002
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http://dx.doi.org/10.3340/jkns.2018.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328791PMC
January 2019
9 Reads

A novel truncating variant of GLI2 associated with Culler-Jones syndrome impairs Hedgehog signalling.

PLoS One 2019 10;14(1):e0210097. Epub 2019 Jan 10.

Centre for Translational Genomics and Bioinformatics, IRCSS San Raffaele Scientific Institute, Milan, Italy.

Background: GLI2 encodes for a transcription factor that controls the expression of several genes in the Hedgehog pathway. Mutations in GLI2 have been described as causative of a spectrum of clinical phenotypes, notably holoprosencephaly, hypopituitarism and postaxial polydactyl.

Methods: In order to identify causative genetic variant, we performed exome sequencing of a trio from an Italian family with multiple affected individuals presenting clinical phenotypes in the Culler-Jones syndrome spectrum. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328167PMC
January 2019

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
2 Reads

High frequency of empty sella, with gender differences, in the early neuroradiology evaluation of patients with traumatic brain injury. A prospective study.

J Clin Transl Endocrinol 2019 Mar 31;15:54-61. Epub 2018 Dec 31.

Department of Clinical and Experimental Medicine, University of Messina, Italy.

One-hundred four persons aged ≥ 18 years (62 males and 42 females) who were admitted for traumatic brain injury (TBI) underwent brain computed tomography (CT) scan and assay of serum cortisol, insulin-like growth factor 1 (IGF-1), thyrotropin (TSH) and free thyroxine (FT4). The main purpose was to assess any gender difference and the rate of empty sella (ES). Women were more likely to have empty sella (19/42 [45. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146237183013
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http://dx.doi.org/10.1016/j.jcte.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317284PMC
March 2019
5 Reads

Pregnancy in Acromegaly is safe and is associated with improvements in GH/IGF-1 concentrations.

Eur J Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

M Sherlock, Academic Department of Diabetes and Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin 9, Ireland.

Pregnancy is rarely reported in acromegaly. Many patients are diagnosed in later life and younger patients may have subfertility due to hypopituitarism. We present a case series of 17 pregnancies in 12 women with acromegaly. Read More

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http://dx.doi.org/10.1530/EJE-18-0688DOI Listing
January 2019
1 Read

Management of hypothalamic disease in patients with craniopharyngioma.

Clin Endocrinol (Oxf) 2019 Jan 4. Epub 2019 Jan 4.

Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. Read More

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http://doi.wiley.com/10.1111/cen.13929
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http://dx.doi.org/10.1111/cen.13929DOI Listing
January 2019
3 Reads

Endoscopic Endonasal Surgery for Craniopharyngiomas: A Series of 60 Patients.

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, First Affiliated Hospital, Chongqing Medical University, Yuzhong District, Chongqing, P.R. China. Electronic address:

Objective: To report our experience of the management of 60 patients with craniopharyngioma with endoscopic endonasal surgery (EES) and evaluate the feasibility and safety of EES for craniopharyngiomas.

Methods: The clinical data of 60 patients with craniopharyngioma who underwent EES between November 2014 and December 2017 were analyzed retrospectively. All patients had vascularized nasoseptal flaps, and the most recent 4 patients had "in situ bone flaps" for better skull base reconstruction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183293
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http://dx.doi.org/10.1016/j.wneu.2018.12.110DOI Listing
January 2019
6 Reads

IgG4-related hypophysitis in patients with autoimmune pancreatitis.

Pituitary 2019 Feb;22(1):54-61

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: IgG4-related disease involves various organs including the pituitary and pancreas. The prevalence of IgG4-related hypophysitis is relatively rare compared with IgG4-related pancreatitis (autoimmune pancreatitis). Although several cases demonstrating both autoimmune pancreatitis and hypophysitis have been reported, the prevalence of IgG4-related hypophysitis in patients with autoimmune pancreatitis remains unknown. Read More

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http://dx.doi.org/10.1007/s11102-018-00930-yDOI Listing
February 2019
1 Read

A novel GLI2 mutation responsible for congenital hypopituitarism and polymalformation syndrome.

Growth Horm IGF Res 2019 02 18;44:17-19. Epub 2018 Dec 18.

Hospital Infantil Universitario Niño Jesús, Departments of Pediatrics & Pediatric Endocrinology, Research Institute "La Princesa", Madrid, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Universidad Autónoma de Madrid, Department of Pediatrics, Madrid, Spain; IMDEA, Food Institute, CEIUAM+CSI, Crta. de Cantoblanco, 8, 28049 Cantoblanco, Madrid, Spain. Electronic address:

Objective: We report a novel GLI2 frameshift mutation and describe the phenotypic spectrum of mutations within this gene.

Patients And Methods: A male with congenital hypopituitarism and polymalformation syndrome was clinically, biochemically and neuroradiologically characterized. Genetic analysis for congenital hypopituitarism was performed using a targeted NGS custom gene panel. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10966374183008
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http://dx.doi.org/10.1016/j.ghir.2018.12.002DOI Listing
February 2019
9 Reads

Transient aggravation of hypopituitarism after parent artery occlusion with low-flow bypass for an unruptured giant cavernous carotid aneurysm: case report.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

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http://dx.doi.org/10.1016/j.wneu.2018.12.020DOI Listing
December 2018

Excess mortality after craniopharyngioma treatment: are we making progress?

Authors:
Nidan Qiao

Endocrine 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurosurgery, Huashan Hospital, Shanghai, China.

Purpose: Craniopharyngioma is associated with an increased risk of mortality even after surgical, radiotherapeutic and hormone supplementations. Previous studies using different designs showed a possible trend of decreasing mortality in recent years. This review summarises studies reporting standardised mortality ratio (SMR) after craniopharyngioma treatment, as well as the bias and confounding in these studies to plan further researches. Read More

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http://dx.doi.org/10.1007/s12020-018-1830-yDOI Listing
December 2018
1 Read

An association with hypopituitarism and 9q subtelomere deletion syndrome.

Clin Case Rep 2018 Dec 25;6(12):2371-2375. Epub 2018 Oct 25.

Department of Pediatrics Keio University School of Medicine Tokyo Japan.

Hypopituitarism could have been overlooked so far in the patients with 9q subtelomere deletion syndrome (9qSTDS); thus, further investigations or reevaluation of clinical information, especially hormonal evaluations, are warranted to determine whether hypopituitarism is a rare or relatively common presentation in patients with 9qSTDS. Read More

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http://dx.doi.org/10.1002/ccr3.1591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293262PMC
December 2018

Pituitary metastasis of breast cancer mimicking IgG4-related hypophysitis.

eNeurologicalSci 2019 Mar 22;14:13-15. Epub 2018 Nov 22.

Department of Neurology, Faculty of Medicine, Fukuoka University, Japan.

IgG4-related hypophysitis, which is the pituitary gland inflammation caused by IgG4 positive lymphocytes, can affect cavernous sinus and orbital apex leading to developing cranial nerve related symptoms such as orbital apex syndrome (OAS). Here we report a case of hypopituitarism associated with OAS caused by pituitary metastasis of the breast cancer with elevated serum IgG4 level, who initially resembled to IgG4-related hypophysitis. Although this case had some features in common with igG4-related hypophysitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056502183004
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http://dx.doi.org/10.1016/j.ensci.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275161PMC
March 2019
5 Reads

Hypopituitarism after Gamma Knife surgery for postoperative nonfunctioning pituitary adenoma.

J Neurosurg 2018 Dec;129(Suppl1):47-54

3Department of Neurosurgery.

OBJECTIVEThis study investigated long-term follow-up data on the combined pituitary function test (CPFT) in patients who had undergone transsphenoidal surgery (TSS) for nonfunctioning pituitary adenoma (NFPA) to determine the clinical parameters indicative of hypopituitarism following postoperative Gamma Knife surgery (GKS).METHODSBetween 2001 and 2015, a total of 971 NFPA patients underwent TSS, and 76 of them (7.8%) underwent postoperative GKS. Read More

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http://dx.doi.org/10.3171/2018.7.GKS181589DOI Listing
December 2018
3.737 Impact Factor

Pituitary Metastasis in a Patient with Pulmonary Adenocarcinoma Presenting with a Disturbance of Consciousness.

Klin Onkol 2018 ;31(5):371-375

Background: Brain metastases are one of the main causes of morbidity and mortality of patients with oncological disease. In non-small cell lung carcinoma (NSCLC), the risk of CNS secondary development is 30-50%. An unusual diagnostic and therapeutic problem is the finding of suspicious pituitary lesions. Read More

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http://dx.doi.org/10.14735/amko2018371DOI Listing
January 2018

Silent somatotropinomas.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Pathology Department, Hospital General Universitario de Alicante, Alicante, Spain.

Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas. SGH-PitNET have deserved little attention in the medical literature, and no specific guidelines exist regarding their management. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02946-2DOI Listing
December 2018
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[Acromegaly].

Ugeskr Laeger 2018 Dec;180(49)

Acromegaly is a rare and disabling disease with a plethora of symptoms and signs attributed to sustained elevations and actions of growth hormone and insulin-like growth factor 1. Acromegaly is characterised by excessive somatic growth and multiple comorbidities in addition to occasional compression of the optic nerve and hypopituitarism due to the underlying adenoma. The course of the disease is insidious, and a diagnostic delay of 5-10 years is typical, and this pre-diagnostic period is also associated with increased morbidity. Read More

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December 2018
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Oxytocin therapy in hypopituitarism: Challenges and opportunities.

Clin Endocrinol (Oxf) 2019 Feb 17;90(2):257-264. Epub 2018 Dec 17.

Schools of Medicine (RB, DAR) and Psychology (KLD), Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Read More

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http://dx.doi.org/10.1111/cen.13909DOI Listing
February 2019
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Role of stereotactic radiosurgery in the treatment of acromegaly.

J Pak Med Assoc 2018 Dec;68(12):1843-1845

Department of Surgery, Section of Neurosurgery, Aga Khan University Hospital, Karachi. Pakistan.

Acromegaly is a rare, indolent disease due to overproduction of growth hormone. Surgery is identified as primary treatment, but has its limitation, thus frequently requiring alternate treatment options as adjunct to surgery. Stereotactic radiosurgery (SRS) has been used as adjuvant and alternate therapy in patients with inoperable or residual disease; or those not fit for surgery. Read More

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December 2018
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Transsphenoidal surgery for pituitary adenomas: early results from a single center.

Hormones (Athens) 2018 Dec 4;17(4):551-556. Epub 2018 Dec 4.

Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy.

Objective: To evaluate early results of transsphenoidal surgery for pituitary adenomas.

Design: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. Read More

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http://dx.doi.org/10.1007/s42000-018-0082-9DOI Listing
December 2018
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A modern series of subdiaphragmatic craniopharyngiomas.

J Neurosurg 2018 Oct 1:1-6. Epub 2018 Oct 1.

6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

OBJECTIVEThe endoscopic endonasal approach has been proposed as a primary surgical strategy for select craniopharyngiomas. However, those tumors that arise from the sella have not been classified with the other craniopharyngioma subtypes in terms of surgical nuances, intraoperative findings, and postoperative outcomes. The authors describe their experience with a select subtype of craniopharyngioma arising within the sella subjacent to the diaphragma sellae and refer to these tumors as type 0. Read More

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http://dx.doi.org/10.3171/2018.4.JNS172330DOI Listing
October 2018
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A neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.

Pituitary 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Box 167, CB2 0QQ, Cambridge, UK.

Purpose: Traumatic brain injury (TBI) is a common cause of mortality and major disability worldwide. The initial management often depends on the severity of the injury. Pituitary dysfunction can develop as a sequela of TBI, and can have long-term, debilitating impact on the patients. Read More

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http://dx.doi.org/10.1007/s11102-018-0925-zDOI Listing
November 2018
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