10,638 results match your criteria Hypopituitarism


[Acromegaly].

Ugeskr Laeger 2018 Dec;180(49)

Acromegaly is a rare and disabling disease with a plethora of symptoms and signs attributed to sustained elevations and actions of growth hormone and insulin-like growth factor 1. Acromegaly is characterised by excessive somatic growth and multiple comorbidities in addition to occasional compression of the optic nerve and hypopituitarism due to the underlying adenoma. The course of the disease is insidious, and a diagnostic delay of 5-10 years is typical, and this pre-diagnostic period is also associated with increased morbidity. Read More

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December 2018

Oxytocin therapy in hypopituitarism: challenges and opportunities.

Clin Endocrinol (Oxf) 2018 Dec 2. Epub 2018 Dec 2.

Schools of Medicine (RB, DAR) and Psychology (KLD), Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.

Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesised in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Read More

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December 2018

Role of stereotactic radiosurgery in the treatment of acromegaly.

J Pak Med Assoc 2018 Dec;68(12):1843-1845

Department of Surgery, Section of Neurosurgery, Aga Khan University Hospital, Karachi. Pakistan.

Acromegaly is a rare, indolent disease due to overproduction of growth hormone. Surgery is identified as primary treatment, but has its limitation, thus frequently requiring alternate treatment options as adjunct to surgery. Stereotactic radiosurgery (SRS) has been used as adjuvant and alternate therapy in patients with inoperable or residual disease; or those not fit for surgery. Read More

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December 2018
2 Reads

Transsphenoidal surgery for pituitary adenomas: early results from a single center.

Hormones (Athens) 2018 Dec 4. Epub 2018 Dec 4.

Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy.

Objective: To evaluate early results of transsphenoidal surgery for pituitary adenomas.

Design: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. Read More

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December 2018

A modern series of subdiaphragmatic craniopharyngiomas.

Authors:

J Neurosurg 2018 Oct 1:1-6. Epub 2018 Oct 1.

OBJECTIVEThe endoscopic endonasal approach has been proposed as a primary surgical strategy for select craniopharyngiomas. However, those tumors that arise from the sella have not been classified with the other craniopharyngioma subtypes in terms of surgical nuances, intraoperative findings, and postoperative outcomes. The authors describe their experience with a select subtype of craniopharyngioma arising within the sella subjacent to the diaphragma sellae and refer to these tumors as type 0. Read More

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October 2018
3 Reads

A neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.

Pituitary 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Box 167, CB2 0QQ, Cambridge, UK.

Purpose: Traumatic brain injury (TBI) is a common cause of mortality and major disability worldwide. The initial management often depends on the severity of the injury. Pituitary dysfunction can develop as a sequela of TBI, and can have long-term, debilitating impact on the patients. Read More

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November 2018

LHX3 deficiency presenting in the United States with severe developmental delay in a child of Syrian refugee parents.

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, California, USA.

In this case report, we present a novel mutation in Lim-homeodomain (LIM-HD) transcription factor, LHX3, manifesting as combined pituitary hormone deficiency (CPHD). This female patient was originally diagnosed in Egypt during infancy with Diamond Blackfan Anemia (DBA) requiring several blood transfusions. Around 10 months of age, she was diagnosed and treated for central hypothyroidism. Read More

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November 2018
3 Reads

Pituitary Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):63-83

Neuroendocrine/Pituitary Program, Division of Endocrinology, Diabetes and Metabolism, University of Florida, 1600 Southwest Archer Road, Room H2, PO Box 100226, Gainesville, FL 32610, USA. Electronic address:

Pregnancy is associated with alterations in pituitary hormonal function and enlargement of the pituitary gland. Pituitary dysfunction diagnosis can be challenging during pregnancy due to known alterations in hormonal status. Pituitary disorders are relatively common; with advancements in medical care, more women with pituitary disorders are becoming pregnant. Read More

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February 2019
1 Read

Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease.

CEN Case Rep 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13. Read More

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November 2018
5 Reads

Pediatric Endoscopic Endonasal Approaches for Skull Base Lesions in the Very Young: Is It Safe and Effective?

J Neurol Surg B Skull Base 2018 Dec 30;79(6):574-579. Epub 2018 Apr 30.

Department of Neurosurgery, University of California San Diego, San Diego, California, United States.

 The fully endoscopic expanded endonasal approach (EEA) has been shown to be safe and efficacious in pediatric patients. However, in the very young patient (ages six and under), the anatomical challenge of working through a small nasal corridor is problematic. The ability to repair the skull base and use a nasoseptal flap (NSF) has also been called into question. Read More

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December 2018

Invasive pituitary adenomas with gross total resection: The wait-and-see policy during postoperative management.

J Clin Neurosci 2018 Dec 24;58:49-55. Epub 2018 Oct 24.

Department of Neurosurgery, West China Hospital of Sichuan University, China. Electronic address:

Although pituitary adenomas (PAs) are regarded as benign neoplasm, efficient postoperative management of PAs, especially invasive PAs, is still a major challenge for neurosurgeons. Thus, in order to verify the effect of postoperative surveillance alone for invasive PAs and identify helpful predictive factors of relapse after initial surgery, a series of 107 cases of surgically gross-totally resected invasive PAs were retrospectively investigated. With regarded to pituitary function, the preoperative incidence of hypothyroidism was higher than that of hypoadrenocorticism and hypogonadism (66. Read More

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December 2018
2 Reads

Long-term efficacy and tolerability of gamma knife radiosurgery for growth hormone-secreting adenoma: A retrospective multi-center study (MERGE-001).

World Neurosurg 2018 Nov 15. Epub 2018 Nov 15.

Department of Neurosurgery. Electronic address:

Objective: Little is known about the long-term efficacy, prognostic factors and tolerability of gamma knife radiosurgery (GKS) for acromegaly. The aim of this study is to investigate long-term hormonal effects, prognostic factors and tolerability of GKS in patients with GH-secreting adenoma.

Methods: Retrospective multi-center study over 25 years with a median follow-up of 85. Read More

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November 2018
2 Reads

Hypothalamic hypopituitarism secondary to suprasellar metastases from small cell lung cancer: a case report and review of the literature.

J Med Case Rep 2018 Nov 18;12(1):342. Epub 2018 Nov 18.

Department of Respiratory Medicine, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura city, Kanagawa, 247-8533, Japan.

Background: Metastasis to the pituitary gland is an infrequent clinical problem, and the symptoms caused by metastases have been reported in only 2.5-18.2% of the cases. Read More

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November 2018
3 Reads

Pituitary tuberculosis presented with pituitary coma.

Tunis Med 2018 Aug - Sep;96(8-09):532-535

Background: Pituitary tuberculosis is very rare. Its diagnosis is difficult unless a bacteriological or histological evidence of tuberculosis.

Observation: We report the case of a 54 years old woman who presented with a pituitary coma that occurred two weeks after the initiation of antituberculous therapy for cervical lymph node tuberculosis. Read More

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November 2018
4 Reads

Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.

J Clin Transl Endocrinol 2018 Dec 26;14:25-33. Epub 2018 Sep 26.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Read More

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December 2018
4 Reads

[Research Advances in Hypothalamic-pituitary Dysfunction Related to Traumatic Brain Injury].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Oct;40(5):699-704

Key Laboratory of Endocrinology of National, Health and Family Planning Commission,Department of Endocrinology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Traumatic brain injury(TBI)is a major cause of hypothalamopituitary dysfunction. TBI-related hypothalamopituitary dysfunction is more common in the acute phase. Disturbance of pituitary/gonadal axis and growth hormone axis,as well as posterior pituitary dysfunction including central diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion,are the most frequently seen. Read More

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October 2018
5 Reads

Hypoxic stress: A risk factor for post-concussive hypopituitarism?

Med Hypotheses 2018 Dec 6;121:31-34. Epub 2018 Sep 6.

Vienna Chiropractic Associates, P.C. (Private Practice of Chiropractic), 243 Church Street NW, #300-B, Vienna, VA 22180, USA. Electronic address:

Hypopituitarism diagnosed months or years following concussive injury can cause a variety of endocrine disturbances including insufficient secretion of human growth, luteinizing, follicle stimulating, thyroid stimulating, adrenocorticotrophic, and antidiuretic hormones. Recent evidence suggests that autoimmune reactions against pituitary and/or hypothalamic tissue constitute an etiologic factor for this hypopituitarism. One important trigger for autoimmunity is hypoxic stress. Read More

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December 2018
2 Reads

Giant Prolactinoma in Men: Clinical Features and Therapeutic Outcomes.

Horm Metab Res 2018 Nov 5;50(11):791-796. Epub 2018 Nov 5.

Department of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

The aim of the study was to evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas). A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. Read More

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November 2018
9 Reads

Trans-eyebrow supraorbital keyhole approach in suprasellar and third ventricular craniopharyngioma surgery: the experience of 27 cases and a literature review.

J Neurooncol 2018 Nov 3. Epub 2018 Nov 3.

Department of Neurosurgery, Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.

Background: The trans-eyebrow supraorbital keyhole approach, a minimal transcranial approach, has been widely used in different types of surgery for sellar and parasellar lesions. In this study, we investigated the outcome of this approach in the surgical treatment of suprasellar and third ventricular craniopharyngioma.

Methods: Twenty-seven patients with suprasellar and third ventricular craniopharyngioma underwent surgery via a supraorbital approach between June 2007 and June 2018. Read More

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November 2018
11 Reads

Coagulative necrotic pituitary adenoma apoplexy: A retrospective study of 21 cases from a large pituitary center in China.

Pituitary 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Purpose: Coagulative necrotic pituitary apoplexy (CNPA) is a clinical entity with unique intraoperative and histopathological manifestations. We aimed to improve the knowledge of this rare disease through the largest case series published to date.

Methods: A retrospective review of 21 CNPA patients was performed from among 5095 patients who underwent surgery for pituitary adenomas at a single institution between January 2009 and June 2017. Read More

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November 2018
4 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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January 2018
7 Reads

Adult Growth Hormone Deficiency: from Transition to Senescence.

Pediatr Endocrinol Rev 2018 Sep;16(Suppl 1):70-79

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

The acute metabolic actions of hGH were discovered in GH-deficient adults (GHDA) 60 years ago and placebo controlled trials of prolonged rhGH replacement therapy appeared 30 years after. Untreated GHDA causes excess morbidity and mortality from cardiovascular disease and the clinical features include fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular risk biomarkers. Several of these abnormalities normalize with GH replacement. Read More

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September 2018
4 Reads

The prevalence and volumetry of pituitary cysts in children with growth hormone deficiency and idiopathic short stature.

J Pediatr Endocrinol Metab 2018 Nov;31(11):1267-1271

Department of Pediatrics, Division of Pediatric Endocrinology, New York Medical College, Valhalla, NY, USA.

Background Pituitary cysts have been speculated to cause endocrinopathies. We sought to describe the prevalence and volumetry of pituitary cysts in patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS). Methods Six hundred and eighteen children evaluated for growth failure at the Division of Pediatric Endocrinology at New York Medical College between the years 2002 and 2012, who underwent GH stimulation testing and had a brain magnetic resonance imaging (MRI) prior to initiating GH treatment were randomly selected to be a part of this study. Read More

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November 2018
3 Reads

Genome-wide methylation study of whole blood cells DNA in men with congenital hypopituitarism disease.

Int J Mol Med 2019 Jan 22;43(1):155-166. Epub 2018 Oct 22.

Clinical Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201821, P.R. China.

Congenital hypopituitarism (CH) is a relatively rare disease that is characterized by the deficiency of one or more hormones secreted by the pituitary gland, which leads to metabolic disorders, amenorrhea and infertility. However, the underlying molecular mechanisms of CH have not yet been fully elucidated. The present study evaluated the genome‑wide methylation level of whole blood DNA in 12 patients with CH and 12 age‑matched controls using Illumina Human Methylation 450 array, in order to determine the roles of epigenetic regulation in the pathogenesis of CH. Read More

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January 2019
3 Reads

Hyponatraemia related to hypopituitarism.

Authors:
G Decaux

Neth J Med 2018 Oct;76(8):387

Department of Internal Medicine, Erasmus University Hospital, Brussels, Belgium.

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October 2018
1 Read

Decreased quality of life (QoL) in hypopituitary patients: involvement of glucocorticoid replacement and radiation therapy.

Pituitary 2018 Dec;21(6):624-630

Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, G-1500, Ann Arbor, MI, 48106, USA.

Purpose: Hypopituitary patients are assumed to have decreased QoL due to GHD. However, in placebo controlled trials, the effects of GH replacement are no different from placebo. Hydrocortisone dose > 20 mg/day and pituitary radiation are independently associated with poorer QoL. Read More

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December 2018

Endoscopic transnasal resection of optic pathway pilocytic astrocytoma.

Childs Nerv Syst 2018 Oct 18. Epub 2018 Oct 18.

Department of Neurosurgery, King Saud University, Riyadh, Saudi Arabia.

Purpose: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Read More

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October 2018
8 Reads
1.160 Impact Factor

Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test.

J Endocr Soc 2018 Aug 26;2(8):860-869. Epub 2018 Jun 26.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Context: GH-releasing peptide 2 (GHRP2) stimulates the hypothalamic-pituitary-adrenal axis (HPA) through the GH secretagogue receptor (GHSR) in the hypothalamus, in which ghrelin is a natural ligand. Therefore, the GHRP2 test (GHRP2T) could be used instead of the insulin tolerance test (ITT).

Objective: Can the GHRP2T replace the ITT for evaluation of HPA?

Design: The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT. Read More

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August 2018
1 Read

A Novel Mutation of in a Patient with Schaaf-Yang Syndrome and Hypopituitarism.

Int J Endocrinol Metab 2018 Jul 1;16(3):e67329. Epub 2018 Jul 1.

Neuropediatric Section, University and Polytechnic Hospital La Fe, Valencia, Spain.

Introduction: Schaaf-Yang syndrome (SYS) is caused by truncating point mutations of the paternal allele of , an imprinted gene located in the critical region of Prader-Willi syndrome (PWS). These patients present a phenotype with neurodevelopmental delay, hypotonia, joint contractures, and a particularly high prevalence of autism (up to 75% in affected individuals). The loss of function of is suggested to contribute to endocrine hypothalamic dysfunction in individuals with PWS. Read More

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July 2018
7 Reads

Patterns of pituitary dysfunction three months or more after traumatic brain injury.

Avicenna J Med 2018 Oct-Dec;8(4):125-132

Department of Medicine, Basrah College of Medicine, Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah, Iraq.

Purpose: Chronic posttraumatic brain injury (TBI) pituitary dysfunction is not a newly discovered subject, it has been reported more frequently, probably due to increasing chances of exposure to its causes, mainly the road traffic accidents, sport-related injuries, falls, and injuries during wars. This study aims to estimate the frequency of pituitary dysfunction 3 months or more after head trauma and the patterns of hormonal deficiencies.

Methods: A cross-sectional study was conducted between January 2016 and August 2017. Read More

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October 2018
4 Reads

Delayed hypopituitarism following Russell's viper envenomation: a case series and literature review.

Pituitary 2018 Oct 13. Epub 2018 Oct 13.

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Whitefield, Bangalore, Karnataka, 560066, India.

Purpose: Hypopituitarism (HP) is an uncommon consequence of Russell's viper envenomation (RVE). Delayed hypopituitarism (DHP) presents months to years after recovering from snake bites (SB). The clinical presentation, manifestations, and outcomes of DHP following RVE have not been systematically studied. Read More

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October 2018
2 Reads

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement

Eur J Endocrinol 2018 10 1;179(4):229-237. Epub 2018 Oct 1.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

Background: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumors in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT).

Methods: Observational cohort study in patients with NFPA within the western region of Sweden. Read More

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October 2018
1 Read

Less known aspects of central hypothyroidism: Part 2 - Congenital etiologies.

J Clin Transl Endocrinol 2018 Dec 27;14:5-11. Epub 2018 Sep 27.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is <1:50,000, and on its etiology, disregarding CH caused by other genetic defects, such as mutations of transcription factors involved in pituitary organogenesis or mutations of the genes encoding TRH or TRH receptor. Read More

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December 2018
11 Reads

VISUAL VIGNETTE.

Endocr Pract 2018 Oct 5. Epub 2018 Oct 5.

From: 1Division of Endocrinology and Metabolism; Department of Medicine; University of Virginia School of Medicine; Charlottesville, VA.

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October 2018

Radiosurgery as primary management for acromegaly.

Clin Endocrinol (Oxf) 2018 Oct 4. Epub 2018 Oct 4.

Academic Unit of Diabetes, Endocrinology & Metabolism, Medical School, University of Sheffield, Sheffield, UK.

Objective: Transsphenoidal surgery (TSS) remains the recommended primary treatment for acromegaly. Long-term outcome data are not available for patients treated with gamma knife radiosurgery (STRS) as a primary treatment.

Design: Retrospective cohort study. Read More

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October 2018
5 Reads

Work disability and its determinants in patients with pituitary tumor-related disease.

Pituitary 2018 Dec;21(6):593-604

Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Introduction: Pituitary tumors may have a considerable impact on patients' functional status, including paid employment, yet research in this area is sparse.

Objective: To describe work disability and its determinants in patients treated for a pituitary tumor.

Methods: Cross-sectional study including patients treated for a pituitary tumor in the working age (18-65 years), who completed five validated questionnaires assessing work disability [Short Form-Health and Labour Questionnaire, Work Role Functioning Questionnaire 2. Read More

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December 2018
1 Read

Non-adenomatous sellar lesions: single-centre 10-year experience.

Hormones (Athens) 2018 Oct 3. Epub 2018 Oct 3.

Pathology Department, Hospital Egas Moniz, Lisbon, Portugal.

Objective: A minority of lesions found in the sellar region are non-adenomatous neoplastic, inflammatory, or cystic masses. Our study aims to describe the prevalence and characteristics of these lesions in a multidisciplinary pituitary outpatient clinic.

Design: We conducted an observational study which included 36 patients (15. Read More

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October 2018
2 Reads

Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series.

Endocrine 2018 Oct 1. Epub 2018 Oct 1.

Department of Endocrinology, Hospital Universitari de Bellvitge, Barcelona, Spain.

Purpose: In 2017, the WHO established that pituicytoma, granular cell tumour (GCT) and spindle cell oncocytoma (SCO) are posterior pituitary tumours (PPT). Recent data suggests that these tumours probably arise from the pituicytes and may constitute a spectrum of a unique histopathological entity. Our aim is to report the clinical findings and surgical outcomes of 16 patients with PPT. Read More

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October 2018
3 Reads

Single center study of 53 consecutive patients with pituitary stalk lesions.

Pituitary 2018 Dec;21(6):605-614

Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Dr Subotica 13, Belgrade, 11000, Serbia.

Background: The etiological spectrum of pituitary stalk lesions (PSL) is wide and yet specific compared to the other diseases of the sellar and suprasellar region. Because of the pituitary stalk's (PS) critical location and role, biopsies of these lesions are rarely performed, and their underlying pathology is often a conundrum for clinicians. A pituitary MRI in association with a clinical context can facilitate their diagnosis. Read More

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December 2018
3 Reads

Heterozygous LHX3 mutations may lead to a mild phenotype of combined pituitary hormone deficiency.

Eur J Hum Genet 2018 Sep 27. Epub 2018 Sep 27.

Aix Marseille Univ, APHM, INSERM, MMG, Hôpital de la Conception, Department of Endocrinology, Marseille, France.

LHX3 is an LIM domain transcription factor involved in the early steps of pituitary ontogenesis. We report here functional studies of three allelic variants, including the first heterozygous variant of LHX3 NM_178138.5(LHX3):c. Read More

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September 2018
1 Read

Recurrent Rathke's Cleft Cysts: Incidence and Surgical Management in a Tertiary Pituitary Center over 2 Decades.

Oper Neurosurg (Hagerstown) 2018 Sep 22. Epub 2018 Sep 22.

Department of Neurological Surgery, University of Southern California Keck School of Medicine, Los Angeles, California.

Background: Limited data exist pertaining to outcomes following surgery for recurrent Rathke's cleft cysts (RCC).

Objective: To determine treatment outcomes in patients undergoing reoperation for recurrent or residual RCCs.

Methods: A retrospective analysis of 112 consecutive RCC operations in 109 patients between 1995 and 2017 was conducted. Read More

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September 2018
5 Reads

Pathophysiology and Individualized Treatment for Hypothalamic Obesity Following Craniopharyngioma and Other Suprasellar Tumors: A Systematic Review.

Endocr Rev 2018 Sep 20. Epub 2018 Sep 20.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

The development of hypothalamic obesity (HO) following craniopharyngioma (CP) and other suprasellar tumors leads to reduced patient quality of life. No treatment algorithms are currently available for management of HO. Depending on which hypothalamic nuclei are destroyed, the pathophysiologic mechanisms and clinical symptoms that contribute to HO differ among patients. Read More

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September 2018
13 Reads

Cleft palate and hypopituitarism in a patient with Noonan-like syndrome with loose anagen hair-1.

Am J Med Genet A 2018 Sep 21;176(9):2024-2027. Epub 2018 Sep 21.

Department of Pediatrics, Division of Genetics and Metabolism, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Noonan syndrome (NS), the most common of the RASopathies, is a developmental disorder caused by heterozygous germline mutations in genes encoding proteins in the RAS-MAPK signaling pathway. Noonan-like syndrome with loose anagen hair (NSLH, including NSLH1, OMIM #607721 and NSLH2, OMIM #617506) is characterized by typical features of NS with additional findings of macrocephaly, loose anagen hair, growth hormone deficiency in some, and a higher incidence of intellectual disability. All NSLH1 reported cases to date have had an SHOC2 c. Read More

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September 2018
2 Reads

Cabergoline for the treatment of bromocriptine-resistant invasive giant prolactinomas.

Endocrine 2018 11 20;62(2):464-469. Epub 2018 Sep 20.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai, China.

Purpose: Few studies have specifically focused on the effect of cabergoline on invasive giant prolactinomas (IGPs) resistant to bromocriptine. This study aims to evaluate whether cabergoline could be used as an effective therapy for patients with bromocriptine-resistant IGPs.

Methods: This retrospective study included 15 patients with bromocriptine-resistant IGPs who received treatment at our department during 2007-2015. Read More

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November 2018
1 Read

Pituitary dysfunction in survivors of Russell's viper snake bite envenomation: A prospective study.

Neurol India 2018 Sep-Oct;66(5):1351-1358

Department of Endocrinology, Postgraduate Institute Medical Education and Research, Chandigarh, Himachal Pradesh, India.

Purpose: Endocrinal insufficiency caused by vasculotoxic snake envenomation is under-recognized and is mostly confined to a specific geographic area. We conducted a prospective study to determine the prevalence and pattern of pituitary-target gland insufficiencies caused by snake envenomation.

Materials And Methods: The hormonal evaluation of patients who had suffered from vasculotoxic snake envenomation was done at baseline and at 6 months of follow-up. Read More

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September 2018
4 Reads
1.080 Impact Factor

Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study.

J Neurooncol 2018 Dec 10;140(3):649-657. Epub 2018 Sep 10.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Purpose: This study evaluated the outcomes of radiotherapy (RT) for spinal ependymoma with adverse features, such as incomplete resection or disseminated disease.

Methods: Twenty-five patients underwent RT for spinal cord ependymoma during 1991-2016. Twenty-four patients had gross disease on the pre-RT spinal magnetic resonance images. Read More

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December 2018
1 Read