Search our Database of Scientific Publications and Authors

I’m looking for a

    5656 results match your criteria Hypophosphatemia

    1 OF 114

    Scoliosis in Fibrous Dysplasia/McCune-Albright Syndrome: Factors Associated with Curve Progression and Effects of Bisphosphonates.
    J Bone Miner Res 2018 Apr 18. Epub 2018 Apr 18.
    Section on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD.
    Background: Scoliosis is a complication of fibrous dysplasia/McCune-Albright syndrome (FD/MAS), however risk factors and long-term outcomes are unknown. Bisphosphonates are commonly used; however, it is unknown whether their use decrease the risk of progressive scoliosis.

    Methods: Clinical data from the NIH cohort study was reviewed. Read More

    [Hypophosphatemia in preterm infants: a bimodal disorder].
    Rev Chil Pediatr 2018 Feb;89(1):10-17
    Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
    New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease. Read More

    Clinical findings and diagnostic procedures in 270 small ruminants with obstructive urolithiasis.
    J Vet Intern Med 2018 Apr 16. Epub 2018 Apr 16.
    Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, Bern 3012, Switzerland.
    Background: Details of the clinical signs of obstructive urolithiasis in male small ruminants have not been documented in a large population.

    Objective: To describe the clinical presentation and diagnostic procedures in a large group of small ruminants with urolithiasis.

    Animals: Two hundred and seventy small ruminants (158 sheep and 112 goats). Read More

    Tumour-induced Osteomalacia Secondary to a Sarcoma.
    Eur Endocrinol 2016 Aug 28;12(2):104-106. Epub 2016 Aug 28.
    Endocrinology Division, University Hospital "Dr. Jose E. Gonzalez", Medical School, Autonomous University of Nuevo Leon, Monterrey, Mexico.
    Tumour-induced osteomalacia (TIO), is a rare paraneoplasatic syndrome found in >95% of benign tumours that secrete fibroblast growth factor 23 - a phosphaturic circulating hormone. A rare case of a TIO secondary to a sarcoma, in a 21-year old man with history of bone fractures and distinctive physical and biochemical characteristics is presented and discussed. Read More

    Severe Hypercalcaemia - Chronic Tophaceous Gout as the Responsible Cause?
    Eur Endocrinol 2015 Aug 19;11(2):102-104. Epub 2015 Aug 19.
    Endocrinology Division, Department of Internal Medicine, University Hospital 'Dr José E González', Unlversldad Autonoma de Nuevo León, Monterrey, México.
    The association of chronic tophaceous gout with severe hypercalcaemia is exceptional. In this case, a 42-year old man with a long-standing history of gout arrived at the emergency room with altered mental status. Laboratory work up revealed a uric acid of 14. Read More

    A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours.
    Invest New Drugs 2018 Apr 10. Epub 2018 Apr 10.
    Peter MacCallum Cancer Centre and Royal Melbourne Hospital, University of Melbourne, 305 Grattan St, Melbourne, VIC, 3000, Australia.
    Background Inhibiting Notch is a promising anti-cancer strategy as it plays a critical role in cancer stem cells maintenance and tumour angiogenesis. BMS-986115 is an orally active, selective inhibitor of gamma-secretase mediated Notch signalling. Method Two dose escalation schedules (Arm-A continuous daily schedule and Arm-B intermittent 2 times weekly schedule) of BMS-986115 were evaluated in advanced solid tumour patients. Read More

    A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer.
    Clin Cancer Res 2018 Apr 10. Epub 2018 Apr 10.
    OB/GYN, University of Oklahoma.
    Purpose: The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is frequently aberrated in cancer. LY3023414 is a potent and selective ATP competitive inhibitor of class I PI3K isoforms, mTOR, and DNA-PK. Here we report the dose escalation results of the first-in-human phase I study of LY3023414. Read More

    Increased circulating FGF23 does not lead to cardiac hypertrophy in the male Hyp mouse model of XLH.
    Endocrinology 2018 Apr 4. Epub 2018 Apr 4.
    Endocrine Unit Massachusetts General Hospital, Boston, Massachusetts.
    Serum levels of fibroblast growth factor 23 (FGF23) markedly increase with renal impairment, with FGF23 levels correlating with the presence of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD). FGF23 activates calcineurin/NFAT signaling and induces hypertrophy in murine cardiomyocytes. X-linked hypophosphatemia (XLH) is characterized by high circulating levels of FGF23, but in contrast to CKD, is associated with hypophosphatemia. Read More

    Progress and Problems in Bone and Mineral Disorders.
    Eur Endocrinol 2017 Apr 3;13(1):19-20. Epub 2017 Apr 3.
    Centre for Endocrinology, Diabetes and Metabolism, Queen Elizabeth Hospital, University Hospitals Birmingham and University of Birmingham, UK.
    A number of new drugs are moving through the osteoporosis therapy pipeline. Some show great promise for patients while one has fallen by the wayside at the last hurdle. New, effective therapies are warmly welcomed but there are still uncertainties around management of osteoporosis with currently available drugs that are contributing to what is commonly being referred to as the 'treatment gap'; a differential between those patients who would benefit from treatment versus those who actually are receiving it. Read More

    Clinical and laboratory features of patients with osteomalacia initially presenting with neurological manifestations.
    Osteoporos Int 2018 Apr 5. Epub 2018 Apr 5.
    Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
    Patients with osteomalacia often visit the neurology department with conditions mimicking other myopathies. We analyzed clinical features of osteomalacia patients who visited the neurology department. These patients frequently presented with hypocalcemia, hypovitaminosis D, and pain with less severe weakness. Read More

    [Relationship between continuous renal replacement therapy and hypophosphatemia in critically ill children].
    Zhonghua Er Ke Za Zhi 2018 Apr;56(4):284-288
    Department of Critical Care Medicine, Children's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200040, China.
    To investigate the incidence and prognosis of hypophosphatemia in critically ill children treated with continuous blood purification (CBP). The medical records of the critically ill patients, who were treated with CBP, admitted to pediatric intensive care unit (PICU) of Shanghai Children's Hospital from May 2014 to April 2017 were retrospectively analyzed. The serum phosphorus levels were tested before CBP, at 48-72 h during CBP, at the end of CBP and on the next day after CBP finished. Read More

    Sjögren's Syndrome Associated with Fanconi's Syndrome and Osteomalacia.
    Am J Case Rep 2018 Apr 3;19:392-396. Epub 2018 Apr 3.
    Department of Rheumatology, Unidad de Enfermedades Reumáticas y Autoinmunes [UNERA] (Unit of Rheumatology and Autoimmune Diseases), Guayaquil, Ecuador.
    BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia. Read More

    Phase I trial of the mTOR inhibitor everolimus in combination with multi-agent chemotherapy in relapsed childhood acute lymphoblastic leukemia.
    Pediatr Blood Cancer 2018 Mar 30:e27062. Epub 2018 Mar 30.
    Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts.
    Background: We sought to determine the feasibility of co-administering everolimus with a four-drug reinduction in children and adolescents with acute lymphoblastic leukemia (ALL) experiencing a first marrow relapse.

    Procedure: This phase I study tested everolimus with vincristine, prednisone, pegaspargase and doxorubicin in patients with marrow relapse occurring >18 months after first complete remission (CR). The primary aim was to identify the maximum tolerated dose of everolimus. Read More

    Polyostotic Fibrous Dysplasia With and Without McCune-Albright Syndrome-Clinical Features in a Nordic Pediatric Cohort.
    Front Endocrinol (Lausanne) 2018 15;9:96. Epub 2018 Mar 15.
    Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
    Objective: Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Read More

    Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats.
    J Med Invest 2018 ;65(1.2):50-55
    Graduate school of Human Science and Environment.
    Refeeding syndrome (RFS) is characterized by the metabolic and clinical changes that occur following aggressive nutritional supplementation in malnourished patients. Hypophosphatemia is the hallmark of RFS and is key to its prevention and treatment in clinical practice. However, the mechanism of hypophosphatemia during RFS is unclear because of the lack of an animal model. Read More

    Steroids and Thyrotoxicosis Precipitate Periodic Paralysis.
    Cureus 2018 Jan 23;10(1):e2106. Epub 2018 Jan 23.
    Internal Medicine, St. Joseph Mercy Oakland Hospital.
    Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. Read More

    Osteomalacia Due To Drug-induced Fanconi Syndrome.
    Arthritis Rheumatol 2018 Mar 25. Epub 2018 Mar 25.
    Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore.
    The patient, a 70-year-old man, presented with bilateral deep knee pain and myalgia for a year. Ten years ago, he was started on adefovir 10mg daily for hepatitis B. He was also on metformin for diabetes mellitus. Read More

    Adverse reactions of sorafenib, sunitinib, and imatinib in treating digestive system tumors.
    Thorac Cancer 2018 Mar 25. Epub 2018 Mar 25.
    Department of Oncology, Peking University International Hospital, Beijing, China.
    Background: This study was conducted to assess the adverse reactions caused by multi-target tyrosine kinase inhibitor treatment of gastrointestinal tumors.

    Methods: We carried out a retrospective study of drug-related adverse reactions in 115 patients who were treated with sorafenib, sunitinib, and imatinib for primary hepatocellular carcinoma or gastrointestinal stromal tumors from October 2003 to March 2012 at the Peking University International Hospital.

    Results: The total incidence of adverse reactions of sorafenib, sunitinib, and imatinib in patients with hepatocellular carcinoma and gastrointestinal stromal tumors was > 80%. Read More

    Suitability of oral administration of monosodium phosphate, disodium phosphate, and magnesium phosphate for the rapid correction of hypophosphatemia in cattle.
    J Vet Intern Med 2018 Mar 23. Epub 2018 Mar 23.
    Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.
    Background: Hypophosphatemia is commonly associated with disease and decreased productivity in dairy cows particularly in early lactation. Oral supplementation with phosphate salts is recognized as suitable for the rapid correction of hypophosphatemia. Little information is available about the differences in efficacy between salts used for oral phosphorus supplementation. Read More

    Maxillary tumour-induced osteomalacia.
    Int J Oral Maxillofac Surg 2018 Mar 20. Epub 2018 Mar 20.
    Department of Oral and Maxillofacial Surgery, the Clinical Research Institute and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:
    Tumour-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, defective vitamin D metabolism, and osteomalacia. In the case reported here, maxillary TIO was not diagnosed for 6years, although initial complaints were reported when the patient was 12years old. Meanwhile she suffered from profound growth limitation, pain, weakness, and spontaneous multiple bone fractures, culminating in complete loss of ambulatory ability and severe limitation in daily activities. Read More

    Phase I Trial of Anti-MET Monoclonal Antibody in MET-Overexpressed Refractory Cancer.
    Clin Colorectal Cancer 2018 Jan 31. Epub 2018 Jan 31.
    Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:
    Background: Samsung Advance Institute of Technology-301 (SAIT301) is a human immunoglobulin G2 antibody that can specifically target mesenchymal epithelial transition factor (c-MET). This novel antibody has higher priority over hepatocyte growth factors when binding to the Sema domain of c-MET and accelerates the internalization and degradation of c-MET, proving its powerful antitumor activities in intra- as well as extracellular areas.

    Materials And Methods: SAIT301 was administered intravenously once every 3 weeks in c-MET overexpressed solid tumor patients, focusing on metastatic colorectal cancer (CRC) according to common clinical phase I criteria. Read More

    Supraventricular tachycardia as a complication of severe diabetic ketoacidosis in an adolescent with new-onset type 1 diabetes.
    BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.
    Department of Paediatrics and Child Health, Cork University Hospital Group, Cork, Ireland.
    Diabetic ketoacidosis (DKA) is one of the most common causes of morbidity and mortality in new-onset type 1 diabetes (T1D). Supraventricular tachycardia (SVT), however, is a very rare complication of DKA. We present the case of a patient with new-onset T1D who presented with DKA. Read More

    A Retrospective Study on the Epidemiological and Clinical Features of Emergency Patients with Large or Massive Consumption of Caffeinated Supplements or Energy Drinks in Japan.
    Intern Med 2018 Mar 9. Epub 2018 Mar 9.
    Department of Forensic Medicine, Tohoku University Graduate School of Medicine, Japan.
    Objective We conducted a retrospective study on the epidemiological and clinical features of patients with acute caffeine poisoning in Japan. Methods Letters requesting participation were sent to 264 emergency departments of hospitals, and questionnaires were mailed to those that agreed to participate. Patients Participants were patients transported to emergency departments of hospitals between April 2011 and March 2016 after consuming large or massive amounts of caffeinated supplements and/or energy drinks (caffeine dose ≥1. Read More

    A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma.
    Cancer Chemother Pharmacol 2018 Mar 8. Epub 2018 Mar 8.
    University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA.
    Purpose: The insulin-like growth factor (IGF) pathway is activated in hepatocarcinogenesis. Cixutumumab is a monoclonal antibody against human insulin-like growth factor-1 receptor (IGF-1R). Given the cross-talk between the IGF and VEGF pathways, we performed a phase I study of the combination of cixutumumab and sorafenib in hepatocellular cancer (HCC). Read More

    Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock.
    J Intensive Care Med 2018 Jan 1:885066618762753. Epub 2018 Jan 1.
    2 Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    Background: Hypo- and hyperphosphatemia are common in severe sepsis and septic shock. Published outcome data in patients with phosphate derangements primarily focus on hypophosphatemia and the general critically ill population. This study aimed to determine the impact of serum phosphate on clinical outcomes in patients with severe sepsis and septic shock. Read More

    Targeting Fibroblast Growth Factor 23 Signaling with Antibodies and Inhibitors, Is There a Rationale?
    Front Endocrinol (Lausanne) 2018 20;9:48. Epub 2018 Feb 20.
    Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
    Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone mainly produced by bone. FGF23 reduces serum phosphate by suppressing intestinal phosphate absorption through reducing 1,25-dihydroxyvitamin D and proximal tubular phosphate reabsorption. Excessive actions of FG23 result in several kinds of hypophosphatemic rickets/osteomalacia including X-linked hypophosphatemic rickets (XLH) and tumor-induced osteomalacia. Read More

    Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome.
    Case Rep Oncol 2018 Jan-Apr;11(1):63-67. Epub 2018 Feb 1.
    Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan.
    Acute lymphoblastic leukemia (ALL) presenting as Fanconi syndrome (FS) is extremely rare. Here, we report a case of ALL presenting as bilateral nephromegaly following FS. A 2-year-old girl was unexpectedly diagnosed with bilateral nephromegaly. Read More

    Use of lispro insulin for treatment of diabetic ketoacidosis in cats.
    J Feline Med Surg 2018 Mar 1:1098612X18761696. Epub 2018 Mar 1.
    Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
    Objectives The aim of this study was to evaluate the efficacy and safety of lispro insulin for the treatment of feline diabetic ketoacidosis (DKA). Times to resolution of hyperglycaemia, ketosis and acidosis were compared between cats treated with continuous rate infusion (CRI) of lispro insulin and cats treated with CRI of regular insulin. Methods Client-owned cats with naturally occurring DKA, newly diagnosed with diabetes mellitus (DM) or already receiving treatment for DM, were included. Read More

    Clinical and genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3.
    PLoS One 2018 5;13(3):e0193388. Epub 2018 Mar 5.
    Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
    Background: Hereditary hypophosphatemia is a group of rare renal phosphate wasting disorders. The diagnosis is based on clinical, radiological, and biochemical features, and may require genetic testing to be confirmed.

    Methodology: Clinical features and mutation spectrum were investigated in patients with hereditary hypophosphatemia. Read More

    FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms in Transgenic Female Mice.
    J Bone Miner Res 2018 Mar 4. Epub 2018 Mar 4.
    Department of Medicine, University of Connecticut School of Medicine, UCONN Health, Farmington, CT, USA.
    Mice overexpressing high molecular weight FGF2 isoforms (HMWTg) in osteoblast lineage phenocopy human X-linked hypophosphatemic rickets (XLH) and a Hyp murine model of XLH demonstrating increased FGF23/FGF receptor signaling and hypophosphatemic rickets/osteomalacia. Because HMWFGF2 was upregulated in bones of Hyp mice and abnormal FGF23 signaling is important in XLH, HMWTg mice were used to examine the effect of the FGF23 neutralizing antibody (FGF23Ab). Eight-week-old female Vector control mice and HMWTg mice were treated with FGF23Ab or control IgG. Read More

    [Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].
    Internist (Berl) 2018 Apr;59(4):326-333
    Institut für Biomedizin des Alterns, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nürnberg, Deutschland.
    Refeeding syndrome is a life-threatening complication that may occur after initiation of nutritional therapy in malnourished patients, as well as after periods of fasting and hunger. Refeeding syndrome can be effectively prevented and treated if its risk factors and pathophysiology are known. The initial measurement of thiamine level and serum electrolytes, including phosphate and magnesium, their supplementation if necessary, and a slow increase in nutritional intake along with close monitoring of serum electrolytes play an important role. Read More

    Prevalence of Risk Factors for the Refeeding Syndrome in Older Hospitalized Patients.
    J Nutr Health Aging 2018 ;22(3):321-327
    Maryam Pourhassan, Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-University Bochum, Germany, Hölkeskampring 40, D- 44625 Herne, Germany,
    Objectives: The incidence of refeeding syndrome (RFS) in older patients is not well-known. The aim of the study was to determine the prevalence of known risk factors for RFS in older individuals during hospitalization at geriatric hospital departments.

    Design And Setting: 342 consecutive older participants (222 females) who admitted at acute geriatric hospital wards were included in a cross-sectional study. Read More

    Oral stomatitis and mTOR inhibitors: A review of current evidence in 20,915 patients.
    Oral Dis 2018 Mar;24(1-2):144-171
    Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
    Background: Traditional treatment of malignancies with chemotherapeutic agents is often affected by the damage inflicted on non-cancerous cells. Toxicities of the oral cavity, such as mucositis and stomatitis, are some of the most significant and unavoidable toxicities associated with anti-cancer therapies. For such reason, in the last decades, newer targeted agents have been developed aiming to decrease the rates of side effects on healthy cells. Read More

    Severe hypophosphataemia: a rare cause of postoperative muscle weakness.
    BMJ Case Rep 2018 Feb 23;2018. Epub 2018 Feb 23.
    Division of Anesthesiology, Mayo Clinic, Rochester, MN, USA.
    We report a case of severe generalised muscle weakness in a 66-year-old man who underwent revision of left knee arthroplasty. On postoperative day 1, he developed non-focal muscle weakness and shortness of breath which progressed over a 6-hour period. Serum phosphorus level was severely low at 0. Read More

    Consequences of an extreme diet in the professional sport: Refeeding syndrome to a bodybuilder.
    Clin Nutr ESPEN 2018 Feb 2;23:253-255. Epub 2017 Nov 2.
    Vilnius University, Faculty of Medicine, Centre of Toxicology, Lithuania.
    Refeeding syndrome, as a life-threatening condition, is well known among severely malnourished or deeply metabolically stressed patients. This case presents an atypical manifestation of the syndrome to a young bodybuilder, whose extreme diet, including 5 months of insufficient nourishment before the sport competition and 6 days of carbohydrates overload afterwards, has led him to a bilateral lower - limb paralysis and drastic homeostatic disturbances. Severe hypokalemia, hypophosphatemia, hypomagnesemia and hyperglycemia with mildly elevated liver enzymes have occurred. Read More

    Outcome of adult patients with X-linked hypophosphatemia caused by PHEX gene mutations.
    J Inherit Metab Dis 2018 Feb 19. Epub 2018 Feb 19.
    Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
    X-linked hypophosphatemia (XLH) is the most common monogenic disorder causing hypophosphatemia. This case-note review documents the clinical features and the complications of treatment in 59 adults (19 male, 40 female) with XLH. XLH is associated with a large number of private mutations; 37 different mutations in the PHEX gene were identified in this cohort, 14 of which have not been previously reported. Read More

    The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma.
    Med Princ Pract 2018 Feb 18. Epub 2018 Feb 18.
    Objective: To investigate the relationship between serum values of magnesium and the parameters of pulmonary function tests (PFT) in patients with chronic asthma.

    Subjects And Methods: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT and details of drug therapy were obtained from each group. Read More

    The refeeding syndrome. Importance of phosphorus.
    Med Clin (Barc) 2018 Feb 12. Epub 2018 Feb 12.
    Servicio de Endocrinología y Nutrición, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
    Refeeding syndrome (RS) is a complex disease that occurs when nutritional support is initiated after a period of starvation. The hallmark feature is the hypophosphataemia, however other biochemical abnormalities like hypokalaemia, hypomagnesaemia, thiamine deficiency and disorder of sodium and fluid balance are common. The incidence of RS is unknown as no universally accepted definition exists, but it is frequently underdiagnosed. Read More

    Phosphaturic mesenchymal tumors: what an endocrinologist should know.
    J Endocrinol Invest 2018 Feb 14. Epub 2018 Feb 14.
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
    Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. Read More

    Association of admission serum levels of vitamin D, calcium, Phosphate, magnesium and parathormone with clinical outcomes in neurosurgical ICU patients.
    Sci Rep 2018 Feb 14;8(1):2965. Epub 2018 Feb 14.
    National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210 patients upon admission. Mean serum 25(OH)D was 21.1 ± 7. Read More

    Associations Between Intravenous Iron, Inflammation and FGF23 in Non-Dialysis Patients with Chronic Kidney Disease Stages 3-5.
    Kidney Blood Press Res 2018 8;43(1):143-151. Epub 2018 Feb 8.
    Background/aims: Both iron deficiency and chronic inflammation are highly prevalent in patients with chronic kidney disease (CKD). The effect of intravenous iron infusion on mineral metabolism in CKD may be modified by inflammation. Intravenous iron theraphy may reduce peripheral degradation, secretion, clearence of iFGF23 and lead to hypophosphatemia. Read More

    Occult phosphaturic mesenchymal tumor of femur cortex causing oncogenic osteomalacia: Diagnostic challenges and clinical outcomes.
    Endokrynol Pol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Endocrinology Diabetology and Metabolic Disorders, Venkateshwar Hospitals, Dwarka, New Delhi.
    Background: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia.

    Patient And Methods: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Read More

    Functions of vitamin D in bone.
    Histochem Cell Biol 2018 Apr 12;149(4):305-312. Epub 2018 Feb 12.
    Department of Medicine, McGill University, Montreal, QC, Canada.
    Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Loss-of function mutations in the genes encoding the enzymes regulating these processes, or in the VDR, result in human diseases, which have demonstrated the paramount role of 1,25(OH)D in mineral and skeletal homeostasis. Mouse genetics has been used to create disease phenocopies which have produced considerable insight into the mechanisms of 1,25(OH)D regulation of mineral and skeletal metabolism. Read More

    Management and prevention of refeeding syndrome in medical inpatients: An evidence-based and consensus-supported algorithm.
    Nutrition 2018 Mar 25;47:13-20. Epub 2017 Sep 25.
    Medical University Department, Clinic for Endocrinology, Metabolism and Clinical Nutrition, Kantonsspital Aarau, Aarau and Medical Faculty of the University of Basel, Basel, Switzerland. Electronic address:
    Objectives: Refeeding syndrome (RFS) can be a life-threatening metabolic condition after nutritional replenishment if not recognized early and treated adequately. There is a lack of evidence-based treatment and monitoring algorithm for daily clinical practice. The aim of the study was to propose an expert consensus guideline for RFS for the medical inpatient (not including anorexic patients) regarding risk factors, diagnostic criteria, and preventive and therapeutic measures based on a previous systematic literature search. Read More

    Rare, genetically conditioned forms of rickets: Differential diagnosis and advances in diagnostics and treatment.
    Clin Genet 2018 Feb 8. Epub 2018 Feb 8.
    Department of Propedeutics Pediatrics and Bone Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
    Apart from the classic forms of rickets, there are rare genetic disorders from the group of vitamin D-resistant rickets where the clinical picture is very similar to the classic forms. Diagnosis of genetically conditioned rickets is often delayed. It is very important to know that a disorder of genetic background may be the cause of the failure of classic treatment in patients with rachitic symptoms. Read More

    Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: A randomized trial.
    Am J Hematol 2018 May 24;93(5):683-690. Epub 2018 Feb 24.
    AMAG Pharmaceuticals, Inc, Waltham, Massachusetts.
    Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia (IDA). This randomized, multicenter, double-blind clinical trial compared the safety, and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with IDA of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1. Read More

    Medical findings in 1,026 consecutive adult inpatient-residential eating disordered patients.
    Int J Eat Disord 2018 Apr 8;51(4):305-313. Epub 2018 Feb 8.
    Eating Recovery Center, Denver, Denver, Colorado.
    Objective: Eating disorders are associated with multiple medical complications. We report contemporary medical data, for newly admitted adult inpatient and residential level of care patients.

    Method: Medical records of a transdiagnostic sample of 1,026 patients, with eating disorders, were retrospectively reviewed for the presence of a broad array of medical complications at time of admission. Read More

    1 OF 114