6,614 results match your criteria Hypophosphatemia


Isolated hypophosphataemia as an early marker of primary hyperparathyroidism.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Endocrinology and Diabetes, Mid-Yorkshire NHS Trust, Wakefield, England.

Summary: Primary hyperparathyroidism (PHPT) is a disease caused by overactive parathyroid glands with consequent hypercalcaemia. The main cause in 85-90% of the cases is the presence of a solitary parathyroid adenoma. The most common presentation is with asymptomatic hypercalcaemia diagnosed on routine biochemical testing. Read More

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Prolonged Hypophosphatemia and Intensive Care After Curative Surgery of Tumor Induced Osteomalacia: A Case Report.

Front Endocrinol (Lausanne) 2021 3;12:686135. Epub 2021 Jun 3.

Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Rare FGF23-producing mesenchymal tumors lead to paraneoplastic tumor-induced osteomalacia (TIO) presenting with phosphate wasting, hypophosphatemia, chronic hypomineralization of the bone, fragility fractures and muscle weakness. Diagnosis of TIO requires exclusion of other etiologies and careful search for a mesenchymal tumor that often is very small and can appear anywhere in the body. Surgical removal of the tumor is the only definitive treatment of TIO. Read More

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Patients with enteral nutrition at risk of refeeding syndrome show electrolyte abnormalities at admission in the Emergency Department.

Nutr Hosp 2021 Jun 21. Epub 2021 Jun 21.

Nutrition and Dietetics Division. Hospital de Clínicas de Porto Alegre. Universidade Federal do Rio Grande do Sul.

Introduction: Refeeding syndrome (RFS) is a metabolic complication in the initial phase of nutritional therapy (NT). Studies evaluating electrolyte abnormalities among patients at risk for RFS undergoing NT in the Emergency Department (ED) are scarce.

Objective: to explore the occurrence of electrolyte abnormalities among patients at risk for RFS with enteral nutrition admitted to the ED. Read More

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Challenges in the management of tumor-induced osteomalacia (TIO).

Bone 2021 Jun 17:116064. Epub 2021 Jun 17.

Julius-Maximilians University, Brettreichstr. 11, 97074, Würzburg, Germany. Electronic address:

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare acquired paraneoplastic disease that is challenging to diagnose and treat. TIO is characterized by hypophosphatemia resulting from excess levels of tumor-secreted fibroblast growth factor 23 (FGF23), one of the key physiological regulators of phosphate metabolism. Elevated FGF23 results in renal phosphate wasting and compromised vitamin D activation, ultimately resulting in osteomalacia. Read More

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Dietary Advice in Hemodialysis Patients: Impact of a Telehealth Approach During the COVID-19 Pandemic.

J Ren Nutr 2021 May 5. Epub 2021 May 5.

Nutrition Department, Nephrocare, Lisbon, Portugal.

Objective: The purpose of this study was to assess the effect of a telehealth-delivered nutritional intervention via telephone in maintenance hemodialysis (HD) patients during the coronavirus outbreak.

Methods: This was a multicenter, observational, prospective, and longitudinal study of 156 patients undergoing maintenance HD from 15 dialysis units conducted during the COVID-19 pandemic. We assigned patients to receive dietary counseling through a phone call, according to their biochemical and nutritional parameters. Read More

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CRRT-associated ketoacidosis: A series of 5 cases.

Clin Nephrol 2021 Jun 18. Epub 2021 Jun 18.

Continuous renal replacement therapy (CRRT) is a dialysis modality used in critically ill patients with acute kidney injury (AKI). Although most dialysate and replacement fluids are dextrose-containing, CRRT-associated hypophosphatemia sometimes warrants the use of phosphorus-containing solutions which are dextrose free. The other less commonly used dextrose-free dialysate solutions are certain formulations of Prismasol and Prismasate. Read More

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Clinical and Genetic Characteristics of 153 Chinese Patients With X-Linked Hypophosphatemia.

Front Cell Dev Biol 2021 1;9:617738. Epub 2021 Jun 1.

Shanghai Clinical Research Center of Bone Diseases, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.

X-linked hypophosphatemia (XLH) is caused by inactivating mutations in the () gene, resulting in an excess of circulating intact fibroblast growth factor-23 (iFGF-23) and a waste of renal phosphate. In the present study, we retrospectively reviewed the clinical and molecular features of 153 Chinese patients, representing 87 familial and 66 sporadic cases with XLH. A total of 153 patients with XLH presented with signs or symptoms at a median age of 18. Read More

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The incidence of the refeeding syndrome. A systematic review and meta-analyses of literature.

Clin Nutr 2021 Apr 22;40(6):3688-3701. Epub 2021 Apr 22.

Department of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126 Turin, Italy.

Background & Aims: The refeeding syndrome (RFS) has been recognized as a potentially life-threatening metabolic complication of re-nutrition, but the definition widely varies and, its incidence is unknown. The aim of this systematic review and meta-analyses was to estimate the incidence of RFS in adults by considering the definition used by the authors as well as the recent criteria proposed by the American Society of Parenteral and Enteral Nutrition (ASPEN) consensus. Furthermore, the incidence of refeeding hypophosphatemia (RH) was also assessed. Read More

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Refeeding syndrome occurs among older adults regardless of refeeding rates: A systematic review.

Nutr Res 2021 May 21;91:1-12. Epub 2021 May 21.

Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo 0130, Norway; Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, Oslo 0424, Norway. Electronic address:

Refeeding syndrome is a life-threatening clinical disorder that can occur when treating malnutrition. The aim was to examine the current knowledge of refeeding syndrome in patients ≥ 65 + years with special focus on the incidence of hypophosphatemia (HP) in relation to refeeding rate (kcal/kg/day), number of days until the lowest level of phosphate occurs (day of nadir), refeeding rates and adverse events, and death. Specifically, we hypothesized that higher energy provision would cause a higher incidence of HP. Read More

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An unexpectedly high incidence of refeeding syndrome in patients with total parenteral nutrition in a reference university hospital.

Clin Nutr 2021 Apr 17;40(6):3702-3707. Epub 2021 Apr 17.

Gastroenterology Service, Hospital de Clínicas de Porto Alegre - RS, Ramiro Barcelos 2350, Rio Grande do Sul, 90035-903, Brazil.

Introduction: Refeeding syndrome occurs with the reintroduction of food after an individual has undergone a substantial period of malnutrition. The development of this condition is not uncommon but is neglected in most cases.

Objective: To identify the incidence of refeeding syndrome in hospitalized patients undergoing total parenteral nutrition and factors that may be associated with this condition. Read More

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Hypovitaminosis D in migrant children in Switzerland: a retrospective study.

Eur J Pediatr 2021 Jun 15. Epub 2021 Jun 15.

Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Cholecalciferol (vitamin D) is essentially known for its role in the phosphocalcic metabolism and its associated pathologies, such as rickets. In Switzerland, 35 to 50% of children are vitamin D deficient. Due to skin colour, poor nutrition, living conditions and cultural practices, migrant population is particularly at risk. Read More

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A Rare Case of Hypophosphataemic Osteomalacia in von Recklinghausen Neurofibromatosis.

Eur J Case Rep Intern Med 2021 25;8(5):002618. Epub 2021 May 25.

Department of Rheumatology, Rabta Hospital, Tunisia.

Background: Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a one of the more common hereditary autosomal disorders. However, osteomalacia in neurofibromatosis type 1 is very rare tumour-induced osteomalacia; fibroblast growth factor-23 is usually implicated.

Patients And Methods: We report the case of a patient with a history of von Recklinghausen neurofibromatosis who presented with hypophosphataemic osteomalacia. Read More

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Distal Renal Tubular Acidosis Accompanied by Severe Hypophosphatemia Mistaken as Fanconi Syndrome in a Kidney-Transplant Patient.

Chonnam Med J 2021 May 24;57(2):166-167. Epub 2021 May 24.

Division of Nephrology, Department of Internal Medicine, Wonkwang University School of Medicine and Hospital, Iksan, Korea.

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The emerging role of phosphorus in human health.

Adv Food Nutr Res 2021 15;96:27-88. Epub 2021 Apr 15.

Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB, Canada.

Phosphorus, an essential nutrient, performs vital functions in skeletal and non-skeletal tissues and is pivotal for energy production. The last two decades of research on the physiological importance of phosphorus have provided several novel insights about its dynamic nature as a nutrient performing functions as a phosphate ion. Phosphorous also acts as a signaling molecule and induces complex physiological responses. Read More

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Extended Whole-body Ga-68 DOTATATE PET-CT in evaluating Tumour-Induced Osteomalacia: Case report and review of literature.

Nucl Med Mol Imaging 2021 Jun 19;55(3):130-135. Epub 2021 Apr 19.

Internal Medicine & Endocrinology, Internal Medicine, Sunway Medical Centre, No. 5 Jalan Lagoon Selatan, Bandar Sunway, 47500 Petaling Jaya, Selangor Darul Ehsan Malaysia.

Tumour-induced osteomalacia is a rare paraneoplastic syndrome that manifests as chronic hypophosphataemia, non-specific bone pain and muscle weakness. It is generally caused by phosphaturic mesenchymal tumour (PMT), which is uncommonly associated with synchronous tumours. However, diagnosis is often delayed for several years due to the rarity, indolent growing nature and non-specific symptoms of the disease, often resulting in an overlook by clinicians during assessments. Read More

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X-linked hypophosphatemia and burosumab: practical clinical points from the French experience.

Joint Bone Spine 2021 Jun 5:105208. Epub 2021 Jun 5.

APHP, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Filière OSCAR, Paris, France; APHP, Endocrinology and Diabetes for Children, Bicêtre Paris-Sud Hospital, Le Kremlin-Bicêtre, France. Electronic address:

Hereditary hypophosphatemia with increased FGF23 levels are rare inherited metabolic diseases characterized by low serum phosphate because of impaired renal tubular phosphate reabsorption. The most common form is X-linked hypophosphatemia (XLH), secondary to a mutation in the PHEX gene. In children, XLH is often manifested by rickets, delayed development of gait, lower limb deformities, growth retardation, craniosynostosis, and spontaneous dental abscesses. Read More

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Pathologic U Waves Secondary to Severe Hypophosphatemia During Refeeding Syndrome.

JAMA Intern Med 2021 Jun 7. Epub 2021 Jun 7.

Department of General Medicine, Christchurch Hospital, Christchurch, New Zealand.

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Cardiac Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Management in a Refeeding Syndrome Patient with Diabetic Ketoacidosis: A Case Report.

Am J Case Rep 2021 Jun 3;22:e930568. Epub 2021 Jun 3.

Department of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.

BACKGROUND Refeeding syndrome is a complex metabolic disorder that develops following rapid nutritional administration after a long period of undernutrition. The onset mechanism involves intracellular transport of phosphorus, potassium, and water, in association with rapid glucose administration. The resulting hypophosphatemia is extremely dangerous and can cause severe heart failure and fatal arrhythmia. Read More

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Incidence of Refeeding Syndrome in Pediatric Inpatients at the US-Mexico Border.

South Med J 2021 Jun;114(6):351-355

From the Paul L. Foster School of Medicine, Texas Tech University Health Science Center at El Paso, El Paso.

Objectives: Refeeding syndrome is a life-threatening, physiological process that occurs when patients with severe malnutrition are too rapidly rehabilitated, leading to the development of electrolyte abnormalities. Hypophosphatemia, a hallmark of the disease, has most commonly been studied, because it is recognized to result in cardiac arrhythmias, seizures, cardiac failure, respiratory failure, rhabdomyolysis, coma, and even death. Although many studies have found caloric intake to be a main causal factor in refeeding syndrome, few have explored other factors, such as geographic location. Read More

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Intravenous Iron-Induced Hypophosphatemia: An Emerging Syndrome.

Adv Ther 2021 May 30. Epub 2021 May 30.

AMAG Pharmaceuticals Inc., Waltham, MA, USA.

Some, but not all, intravenous iron formulations have been recognized to induce renal phosphate wasting syndrome. Most commonly this has been reported following treatment of iron deficiency anemia (IDA) with ferric carboxymaltose (FCM). A search of PubMed identified relevant randomized controlled trials (RCTs), and case studies evaluating hypophosphatemia (HPP) resulting from intravenous iron treatment. Read More

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Monitoring response to conventional treatment in children with XLH: Value of ALP and Rickets Severity Score (RSS) in a real world setting.

Bone 2021 May 28;151:116025. Epub 2021 May 28.

Royal Manchester Children's Hospital, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Introduction: X-linked hypophosphataemia (XLH) is conventionally managed with oral phosphate and active vitamin D analogues.

Objectives: To evaluate long term treatment response by assessing biochemical disease activity [serum alkaline phosphatase (ALP)], radiological rickets severity score (RSS), growth and morbidity in patients with XLH on conventional therapy and assess the correlation between serum ALP and RSS.

Methods: XLH patients from 3 UK tertiary centres with ≥3 radiographs one year apart were included. Read More

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The role of phosphate in alcohol-induced experimental pancreatitis.

Gastroenterology 2021 May 26. Epub 2021 May 26.

Department of Medicine, Duke University Medical Center, Durham, NC; Department of Veterans Affairs Health Care System, Durham, NC. Electronic address:

Background And Aims: Heavy alcohol consumption is a common cause of acute pancreatitis, however, alcohol abuse does not always result in clinical pancreatitis. As a consequence, the factors responsible for alcohol-induced pancreatitis are not well understood. In experimental animals it has been difficult to produce pancreatitis with alcohol. Read More

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Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock.

BMC Pharmacol Toxicol 2021 May 28;22(1):30. Epub 2021 May 28.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Objective: The aim of this study is to examine the association of hypophosphatemia and hyperphosphatemia on the first day of ICU admission with mortality in septic critically ill patients.

Methods: In this retrospective cohort study, all adult patients who were admitted to the medical-surgical ICUs between 2014 and 2017 with sepsis or septic shock were categorized as having hypophosphatemia, normophosphatemia and hyperphosphatemia based on day 1 serum phosphate values. We compared the clinical characteristics and outcomes between the three groups. Read More

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Serum phosphate and mortality in incident dialysis patients in Australia and New Zealand.

Nephrology (Carlton) 2021 May 28. Epub 2021 May 28.

Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.

Aim: Hyperphosphataemia is associated with increased adverse outcomes, including mortality. Re-examining this association using up-to-date data reflecting current and real-world practices, across different global regions and in both haemodialysis and peritoneal dialysis patients, is important.

Methods: We describe the association between serum phosphate and all-cause and cardiovascular mortality in incident dialysis patients between 2008 and 2018 using the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Read More

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Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH.

PLoS One 2021 27;16(5):e0252348. Epub 2021 May 27.

Harvard Medical School, Boston, Massachusetts, United States of America.

Osteocytes remodel the perilacunar matrix and canaliculi. X-linked hypophosphatemia (XLH) is characterized by elevated serum levels of fibroblast growth factor 23 (FGF23), leading to decreased 1,25 dihydroxyvitamin D3 (1,25D) production and hypophosphatemia. Bones from mice with XLH (Hyp) have enlarged osteocyte lacunae, enhanced osteocyte expression of genes of bone remodeling, and impaired canalicular structure. Read More

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Republished: Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis.

Drug Ther Bull 2021 May 24. Epub 2021 May 24.

Department of Internal Medicine M, Geriatric Section, Amager Hvidovre Hospital, Glostrup, Denmark.

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Tenofovir-induced osteomalacia with hypophosphataemia.

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada

Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug widely used as a first-line treatment of hepatitis B virus (HBV) and HIV. Increasing evidence has emerged associating its use with the development of Fanconi syndrome, renal insufficiency and bone disease. We report a case of a 61-year-old woman with a remote history of liver transplant for cirrhosis due to HBV. Read More

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Rare variant with insidious presentation leads to a delayed diagnosis of X-linked hypophosphatemia.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Pediatrics, Section of Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.

A 7-year-old girl without a significant previous medical history was diagnosed with X-linked hypophosphatemic rickets (XLHR) due to a rare, most likely pathogenic, gene variant after a 4-year delayed diagnosis due to mild clinical presentation. At 2 years of age, her intoeing and femoral bowing were attributed to physiologic bowing and borderline vitamin D sufficiency, despite phosphorus not being measured. Hypophosphatemia was eventually detected after incomplete improvement of bowing and leg length discrepancy with suboptimal linear growth. Read More

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Serum electrolytes and renal alterations in HIV-seropositive Mexican subjects.

Medicine (Baltimore) 2021 May;100(20):e26016

Departamento de Inmunobiología Molecular, Centro de Investigación Biomédica, Facultad de Medicina Universidad Autónoma de Coahuila.

Abstract: To examine potential risk factors associated with biochemical alterations in renal function in a population diagnosed with HIV/AIDS undergoing antiretroviral treatment.This is an observational, transversal, and relational design study that included 179 HIV-seropositive subjects. Glucose serum, cholesterol, triglycerides, total proteins, albumin, creatine, urea, blood urea nitrogen (BUN), and electrolytes levels were determined for each individual. Read More

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