9,019 results match your criteria Hypopharyngeal Cancer
Head Neck 2018 Dec 10. Epub 2018 Dec 10.
Department of Radiation Therapeutics and Oncology, Tokyo Medical and Dental University, Tokyo, Japan.
Background: This study investigates the prognostic value of metabolic tumor burden calculated using dual-time-point 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT in patients with locally advanced cancer.
Methods: This study examines 42 patients (35 men and 7 women, 38-73 years old) with locally advanced oropharyngeal or hypopharyngeal cancer who had undergone FDG-PET/CT before receiving chemoradiotherapy. Maximum standardized uptake value (SUV ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured for the early and delayed phases. Read More
Head Neck 2018 Dec 11. Epub 2018 Dec 11.
Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.
Background: Our objective was to determine the effect of post-diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.
Methods: Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical-pathologic data, aspirin prescriptions, and outcome. Read More
Head Neck 2018 Dec 7. Epub 2018 Dec 7.
Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Background: The purpose of this study was to retrospectively evaluate the usefulness of pretreatment positron emission tomography (PET) using metabolic tumor volume (MTV) of the primary tumor and lymph nodes in advanced hypopharyngeal cancer.
Methods: From June 2007 to December 2015, consecutive patients with advanced hypopharyngeal cancer who underwent PET and were treated with definitive radiation therapy were retrospectively reviewed.
Results: A total of 61 patients were eligible for this study. Read More
Head Neck 2018 Dec 10. Epub 2018 Dec 10.
Department of Otolaryngology - Head & Neck Surgery, Division of Head & Neck Oncology, University of Toronto, Sunnybrook Health Sciences and the Odette Cancer Centre, Michael Garron Hospital, Toronto, Ontario, Canada.
Locoregional recurrent/persistent head and neck cancer following primary treatment is a significant challenge as it is usually difficult to treat and has worse outcomes compared to the primary setting. Surgical resection of a local or regional recurrence offers the best chance of cure when feasible. Local recurrence outcomes vary by subsite with laryngeal recurrences having the best prognoses and hypopharynx having the worst. Read More
Oncol Rep 2018 Dec 6. Epub 2018 Dec 6.
Department of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
Laryngeal carcinoma is one of the most common tumors concerning otorhinolaryngology head and neck surgery, however, the pathogenesis of laryngeal carcinoma remains unclear. MicroRNAs (miRNAs) have been reported to play vital roles in the pathogenesis of laryngeal carcinoma Herein, the present study was designed to explore the function and mechanism of miRNA‑98 in hypopharyngeal carcinoma. In brief, qRT‑PCR, MTT assay, western blot analysis, Transwell assay and luciferase reporter assay were performed. Read More
Acta Otorrinolaringol Esp 2018 Dec 5. Epub 2018 Dec 5.
Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.
Introduction And Objectives: The treatment of locally advanced carcinomas of the hypopharynx may include surgery or several combinations of radiotherapy and chemotherapy as organ preservation strategies. The objective of the present study is to analyze the results of locally advanced hypopharyngeal carcinoma patients treated in a single centre over a 30-year period.
Methods: Retrospective chart review of 278 patients with T3-T4 hypopharyngeal carcinomas treated between 1985 and 2015 at a tertiary institution. Read More
Oral Oncol 2018 Dec;87:179-185
Department of Radiotherapy, Batra Hospital, Tughlakabad Institutional Area, Mehrauli Badarpur Road, Near Saket Metro Station, New Delhi, Delhi 110062, India.
Objective: Nodal volume as a prognostic factor has been extensively evaluated in head and neck cancer, however there is still no consensus. We attempted to analyze nodal volume as a prognostic factor in head and neck cancer treated with chemoradiation (CCRT) without an elective neck dissection with image guided intensity modulated radiotherapy (IG-IMRT).
Material And Methods: We prospectively analysed 87 patients of Stage III-IV cancer of the oropharynx (57), and hypopharynx (30), who subsequently received definitive concurrent chemoradiation. Read More
Oral Oncol 2018 Dec 3;87:131-137. Epub 2018 Nov 3.
Radiation Oncology Department, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Sorbonne University, Paris, France.
Target volume selection and delineation for both the primary tumor and the lymph nodes are critical steps in the treatment of head and neck tumors with Intensity Modulated Radiation therapy (IMRT). These steps should be based on a probabilistic approach, which is that selection and delineation will be considered as optimal when reaching the best compromise between a too tight volume that could be associated to an unacceptable rate of local recurrence, and a too large volume, which could be associated to an unacceptable rate of treatment morbidity. Failure to do so have been reported to be associated to a higher risk of loco-regional recurrences and/or morbidity after treatment. Read More
Head Neck 2018 Dec 3. Epub 2018 Dec 3.
University of Toronto, Faculty of Medicine, Department of Otolaryngology - Head and Neck Surgery, 200 Elizabeth Street, 8th Floor 8NU 881, Toronto, Ontario, Canada M5G 2C4.
Background: Surgeons have developed various reconstructive techniques to minimize the rate of pharyngocutaneous fistula and optimize functional outcome after salvage laryngectomy or laryngopharyngectomy.
Methods: Multicenter retrospective review at 33 institutions of 486 patients with a history of squamous cell carcinoma (SCC) of the larynx or hypopharynx previously treated with primary chemoradiotherapy (CRT) who required salvage surgery. Outcomes evaluated were overall fistula rate, fistula requiring reoperation, and 12-month speech and swallowing function. Read More
Curr Opin Otolaryngol Head Neck Surg 2018 Nov 16. Epub 2018 Nov 16.
Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Purpose Of Review: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.
Recent Findings: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Read More
Clin Transl Oncol 2018 Nov 30. Epub 2018 Nov 30.
Department of Radiation Oncology, GenesisCare, Madrid, Spain.
Purpose: The present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx.
Methods/patients: We performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66-69.96 Gy in 33 fractions between 2008 and 2016. Read More
Indian J Plast Surg 2018 May-Aug;51(2):190-195
Department of Head and Neck Oncology, Amrita Hospital, Kochi, Kerala, India.
Background: Pharyngeal reconstruction is a challenging aspect of reconstruction after resections for head-and-neck cancer. The goals of reconstruction are to restore the continuity of the pharyngeal passage to enable oral alimentation and rehabilitation of speech wherever possible. This study was performed to determine the outcomes following pharyngeal reconstruction in total laryngectomy (TL) using different reconstructive options and to determine the predictors of pharyngocutaneous fistula (PCF) and swallowing dysfunction. Read More
Eur Arch Otorhinolaryngol 2018 Dec 4. Epub 2018 Dec 4.
Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Purpose: The majority of head and neck squamous cell carcinoma (HNSCC) cases in developing countries are associated with cigarette smoking and TP53 mutations. p53 is a transcription factor that activates downstream genes, including the hsa-miR-34a and hsa-miR-34b/c loci, to achieve cell-cycle arrest, senescence, and/or apoptosis. This study examined the differences in expression levels of miR-34 in HNSCC with or without TP53 mutations. Read More
J Otolaryngol Head Neck Surg 2018 Dec 4;47(1):74. Epub 2018 Dec 4.
Department of Otolaryngology, Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Module S - Room M2566, Box 216, Ottawa, ON, K1H 8L6, Canada.
Background: We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC).
Methods: A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. Read More
J Clin Med 2018 Dec 3;7(12). Epub 2018 Dec 3.
Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Background: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR) in patients treated with definitive radiotherapy (RT) for head and neck cancer.
Methods: We retrospectively analyzed 621 patients who received definitive RT for nasopharyngeal, oropharyngeal, hypopharyngeal, and laryngeal cancer. An NLR cut-off value of 2. Read More
Otolaryngol Head Neck Surg 2018 Dec 4:194599818815658. Epub 2018 Dec 4.
1 Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Egypt.
We provide expansion hyoidthyroidpexy as a novel surgical procedure for obstructive sleep apnea (OSA) that could combine different techniques of hyoid bone surgery in 1 procedure. This case series included patients with OSA who had an apnea-hypopnea index (AHI) >15 and showed predominant lateral wall hypopharyngeal collapse. In 21 patients, the procedure was performed smoothly without technical difficulties or operative adverse events, resulting in lateral expansion of each horn of the hyoid bone by ≥1 cm without early or late complications. Read More
Clin Otolaryngol 2018 Nov 30. Epub 2018 Nov 30.
Department of Otolaryngology, Head& Neck Surgery, Edinburgh Cancer Centre, Western General Hospital, Edinburgh.
The rate of occult nodal metastases during primary laryngectomy with no clinical or radiological evidence of neck disease (cN0) has been found to be as high as 20%. Therefore, bilateral elective neck dissection is usually recommended. However, the role of neck dissection in the salvage laryngectomy setting remains unclear. Read More
Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.
From the Department of Cellular Pathology, University of Liverpool, Liverpool, United Kingdom (Dr Helliwell); the Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri (Dr Chernock); ANU College of Health and Medicine, Anatomical Pathology, ACT Pathology, Canberra Hospital, Woden, Australia (Dr Dahlstrom); Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia (Drs Gale and Zidar); the Department of Pathology, Michigan Medicine - University of Michigan, Ann Arbor (Dr McHugh); the Department of Anatomic Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada (Dr Perez-Ordoñez); the Department of ENT-Head and Neck Surgery, University Hospital Aintree, Liverpool, United Kingdom (Dr Roland); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills (Dr Thompson).
The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Standardized pathologic reporting for cancers facilitates improved communication for patient care and prognosis and the comparison of data between countries to progressively improve clinical outcomes. Laryngeal cancers are often accompanied by significant morbidity, although surgical advances (such as transoral endoscopic laser microresection and transoral robotic surgery) provide new alternatives. Read More
Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.
From the Department of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (Dr Bullock); the Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (Dr Beitler); the Pathology and Laboratory Medicine Institute, Cleveland Clinic, Weston, Florida (Dr Carlson); the Instituto de Anatomia Patológica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal (Dr Fonseca); the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Hunt); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Katabi); the Department of Cellular Pathology, Newcastle University, Newcastle upon Tyne, United Kingdom (Dr Sloan); the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada (Dr Taylor); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Williams); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).
Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories. Read More
Bull Exp Biol Med 2018 Dec 28;166(2):250-252. Epub 2018 Nov 28.
Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
The model of head and neck squamous cell carcinoma (HNSCC) was used to study the expression of genes encoding actin-binding proteins depending on the type of cell motility. The expression of SNAIL1 and CAPN2 mRNA in HNSCC tissue was higher than in specimens of dysplastic epithelium of the larynx and hypopharynx, which can be explained by activation of mesenchymal and amoeboid types of cell motility. In biopsy material of HNSCC patients with T1-2N0M0, expression of genes responsible for actin-binding proteins differed from that of patients with pretumor pathology of the larynx and hypopharynx: expression of FSCN was lower, while expressions of EZR and CAP1 were higher. Read More
World J Gastrointest Endosc 2018 Nov;10(11):367-377
Department of Radiodiagnosis and Imaging, Fortis Hospital, Ludhiana 140012, Punjab, India.
Aim: To investigate the role of a novel minimally invasive endoscopic technique in the management of tight near-total corrosive strictures of the proximal esophagus involving the hypopharynx.
Methods: Two patients with near-total corrosive strictures of the proximal esophagus involving the hypopharynx were managed with the novel endoscopic technique. The technique involved passing a 0. Read More
Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):419-423
Department of Orthodontics, Hangzhou West Dental Hospital. Hangzhou 310013, Zhejiang Province, China.
Purpose: To investigate the effect of maximum anchorage on upper airway in adolescent patients with bimaxillary protrusion and extraction from three-dimensional direction on cone-beam computed tomography(CBCT).
Methods: A retrospective evaluation was carried out on pre- and post-orthodontic treatment records of 50 adolescents with bimaxillary protrusion treated by maximum anchorage extraction. The changes on upper airway pre- and post-treatment were measured. Read More
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 25. Epub 2018 Oct 25.
Services d'otorhinolaryngologie et de chirurgie cervicofaciale; Department of otorhinolaryngology head neck surgery, Stanford University, Palo Alto, CA, USA.
Based on a review of the medical literature, the authors document the key technical points, variants, technical errors to avoid and main functional results of lateral pharyngotomy for resection of cancers originating from the lateral oro and/or hypopharynx. Read More
Cancer Med 2018 Nov 26. Epub 2018 Nov 26.
Ewha Womans University Graduate School of Medicine, Seoul, Korea.
Objectives: To compare overall survival (OS) in locally advanced hypopharyngeal cancer treated with surgery or definitive chemoradiotherapy in the contemporary era.
Methods: From 2010 to 2015, data for patients diagnosed with hypopharyngeal cancer (T2-T4aM0) and treated with total pharyngectomy with lymph node dissection (surgery group) or definitive radiotherapy and chemotherapy (chemoradiotherapy group) was retrieved from the SEER database. Multivariate analyses were performed in each subgroup divided according to T category (T2-3 or T4a). Read More
Otolaryngol Head Neck Surg 2018 Nov 27:194599818813337. Epub 2018 Nov 27.
2 Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
Objective: To investigate readmissions among adult inpatients who underwent uvulopalatopharyngoplasty (UPPP) in Taiwan.
Design: Population-based survey.
Setting: Retrospective study with the National Health Insurance Database. Read More
JAMA Otolaryngol Head Neck Surg 2018 Nov 21. Epub 2018 Nov 21.
Armstrong Institute for Patient Safety and Quality, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Importance: A volume-outcome association exists for larynx cancer surgery, but to date it has not been investigated for specific surgical procedures.
Objectives: To characterize the volume-outcome association specifically for laryngectomy surgery and to identify a minimum hospital volume threshold associated with improved outcomes.
Design, Setting, And Participants: In this cross-sectional study, the Nationwide Inpatient Sample was used to identify 45 156 patients who underwent laryngectomy procedures for a malignant laryngeal or hypopharyngeal neoplasm between January 2001 and December 2011. Read More
Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.
Institute of Pathology, Technical University of Munich.
Squamous cell carcinoma (SCC) is the most common cancer of the head and neck region including-among others-laryngeal (LSCC) and hypopharyngeal (HSCC) subsites. LSCC/HSCC are heterogenous diseases with respect to patient outcome. Currently, tumor stage-based patient stratification is essential to predict prognosis and thus selection of the appropriate treatment modalities. Read More
Maxillofac Plast Reconstr Surg 2018 Dec 9;40(1):33. Epub 2018 Nov 9.
Department of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-Gu, Seoul, 06351 Republic of Korea.
Background: Bimaxillary orthognathic surgery with maxillomandibular setback is often accompanied by changes in airway space. We analyzed the changes in airway space before and after surgery and assessed their association with obstructive sleep apnea.
Methods: This study is based on the cohort of 13 adult patients (9 males, 4 females, average age 23. Read More
Pan Afr Med J 2018;30:185. Epub 2018 Jun 28.
Trauma Unit, Tygerberg Hospital Cape Town, South Africa.
Arch Phys Med Rehabil 2018 Nov 16. Epub 2018 Nov 16.
Department of Physical Medicine and Rehabilitation.
Objective: To determine differences between continuous videofluoroscopic swallow studies (VFSS) with a pulse rate and frame rate of 30 and the same swallows reduced to 15 frames per second (fps) on measures of swallowing function in patients after acute ischemic stroke.
Design: Blinded comparison.
Setting: Acute hospital. Read More
Surg Oncol 2018 Dec 11;27(4):767-772. Epub 2018 Oct 11.
Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France. Electronic address:
Objectives: To evaluate the clinical outcomes of total pharyngolaryngectomy (TPL) in the elderly and to analyze the impact of age on postoperative complications and oncologic and functional outcomes.
Methods: We conducted a retrospective review of the medical records of all patients who underwent TPL for a laryngeal or hypopharyngeal squamous cell carcinoma, between 2000 and 2015. The impact of advanced age (>70 years) on clinical outcomes was assessed in univariate and multivariate analyses. Read More
Clin Otolaryngol 2018 Nov 16. Epub 2018 Nov 16.
Department of Oral Medicine, The First affiliated hospital of Zhengzhou University, Zhengzhou, PR China.
The natural history of untreated head and neck squamous cell carcinoma (SCC) was not well defined. A total of 206 patients with untreated head and neck SCC were retrospectively enrolled. The 1-year survival rate for cancers arising in oral cavity, oropharynx, throat, and hypopharynx was 31%, 20%, 0%, and 3%, respectively, the difference was significant (p<0. Read More
Laryngoscope 2018 Nov 15. Epub 2018 Nov 15.
Department of Otolaryngology-Head and Neck Surgery, Head and Neck Center, Rambam Health Care Campus, Haifa, Israel.
Objectives/hypothesis: This study aimed to evaluate the long-term swallowing performance following transoral robotic surgery (TORS) to the base of tongue (BOT) in the treatment of obstructive sleep apnea (OSA).
Study Design: Retrospective and prospective cohort study.
Methods: Data analysis of 39 patients who underwent BOT reduction via TORS to treat OSA at our center from September 2013 to April 2016. Read More
Cancer Manag Res 2018 10;10:4679-4688. Epub 2018 Oct 10.
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China,
Purpose: To analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma.
Patients And Methods: Between August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. Read More
Onco Targets Ther 2018 24;11:7395-7405. Epub 2018 Oct 24.
Department of Otorhinolaryngology- Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China,
Objective: Hypopharyngeal squamous cell carcinoma (HSCC) remains one of the most lethal malignancies in head and neck. Notch1 has been validated to play prominent roles in the occurrence and development of various types of cancer. The aim of this study was to explore the function and underlying mechanism of Notch1 in HSCC. Read More
Ann Plast Surg 2019 Jan;82(1S Suppl 1):S2-S5
School of Medicine, Griffith University, Gold Coast, Queensland, Australia.
Background: Most of the patients with hypopharyngeal cancer are still diagnosed with advanced stage, and total or partial pharyngectomy with free flap reconstruction is the mainstay of treatment. The aim of this study was to find out the possible risk factors related to surgical complications after free fasciocutaneous flap reconstruction for partial pharyngeal defect and its sequelae in the follow-up.
Patients And Methods: We retrospectively reviewed the charts of patients with advanced hypopharyngeal cancer who received free fasciocutaneous flaps for partial pharyngeal defects reconstruction. Read More
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Nov;32(11):1441-1445
Department of Oncology Plastic Surgery, Hunan Cancer Hospital, Changsha Hunan, 410008, P.R.China.
Objective: To explore the effectiveness of pedicled chimeric thoracoacromial artery perforator (TAAP) flap as a reconstructive option for circular hypopharyngeal defects.
Methods: Between January 2013 and December 2014, the pedicled chimeric TAAP flap was used to repair oncologic circular hypopharyngeal defects in 8 patients, included 6 males and 2 females, with an average age of 57 years (range, 45-80 years). All patients were treated in other hospitals before and recurrence was noted. Read More
Ann Oncol 2018 Oct;29(10):2105-2114
Charité Comprehensive Cancer Center, Berlin, Germany.
Background: The German multicenter randomized phase II larynx organ preservation (LOP) trial DeLOS-II was carried out to prove the hypothesis that cetuximab (E) added to induction chemotherapy (IC) and radiotherapy improves laryngectomy-free survival (LFS; survival with preserved larynx) in locally advanced laryngeal/hypopharyngeal cancer (LHSCC).
Patients And Methods: Treatment-naïve patients with stage III/IV LHSCC amenable to total laryngectomy (TL) were randomized to three cycles IC with TPF [docetaxel (T) and cisplatin (P) 75 mg/m2/day 1, 5-FU (F) 750 mg/m2/day days 1-5] followed by radiotherapy (69.6 Gy) without (A) or with (B) standard dose cetuximab for 16 weeks throughout IC and radiotherapy (TPFE). Read More
Clin Otolaryngol 2018 Nov 9. Epub 2018 Nov 9.
Institute for Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.
Objectives: The main purpose of this study was to evaluate flap size and flap design of skin islands in myocutaneous serratus anterior free flaps (SAFFs) in fresh cadavers and to further investigate whether myocutaneous SAFFs are suitable flaps for pharyngeal reconstruction after laryngopharyngectomy.
Methods: Dissection and injection of methylene blue were performed in 20 hemithoraces of 13 fresh cadavers to evaluate flap size and location of skin islands. Based on these pre-clinical data, we performed pharyngeal reconstruction with myocutaneous SAFF in five patients after laryngopharyngectomy. Read More
J Cancer 2018 16;9(21):4009-4017. Epub 2018 Oct 16.
Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Basaloid squamous cell carcinoma (BSCC) is a rare, high-grade variant of squamous cell carcinoma (SCC). Most published studies based on population-based datasets focus on prognostic differences between SCC and BSCC. Competing risk analyses for this disease have not been performed. Read More
Onco Targets Ther 2018 16;11:7053-7059. Epub 2018 Oct 16.
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, People's Republic of China,
Background: The aim of this study was to validate the antitumor function of EGFR-chimeric antigen T-cells (CART) targeted to FaDu cells, a hypopharyngeal squamous cell carcinoma cell line, and to provide a preclinical basis for the application of CART cell technology in hypopharyngeal squamous cell carcinoma.
Methods: Detection of cytokine secretions of EGFR-CAR T and CART-controls in the presence of target cells and nontarget cells as an indicator of CART cell activation. Detection of the cytotoxic effects of EGFR-CAR T on specific tumors in the presence of target cells was evaluated by LDH release and CART cell proliferation. Read More
Indian J Palliat Care 2018 Oct-Dec;24(4):446-450
Department of Biostatistics, St. John's Medical College, Bengaluru, Karnataka, India.
Introduction: The competing (noncancer) deaths have increased with aggressive treatment approach and better disease control in locally advanced head-and-neck cancer.
Aim: The aim of this study is to find incidence, cause and predictors of early competing mortality in locally advanced head-and-neck cancer patients undergoing combined modality therapy.
Subjects And Methods: In this retrospective study, a total of 125 locally advanced head-and-neck patients treated from January 2013 to June 2017 were analyzed. Read More
Oral Oncol 2018 Nov 13;86:301-306. Epub 2018 Oct 13.
The Ohio State University, Department of Radiation Oncology, 320 West 10th Avenue, Columbus, OH 43210, USA.
The larynx is an organ of the upper aerodigestive tract that is involved in many critical functions such as breathing, speaking, and swallowing. As a result, both larynx cancer and its treatment may significantly affect quality of life. The management of laryngeal cancer has focused on improving survival while preserving the function of the organ. Read More
Oral Oncol 2018 Nov 4;86:244-250. Epub 2018 Oct 4.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA. Electronic address:
Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30-35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. Read More
Oral Oncol 2018 Nov 25;86:165-170. Epub 2018 Sep 25.
Department of Surgery, University Cancer Institute Toulouse-Oncopole University Hospital of Toulouse, 1 Avenue Irène Joliot-Curie, 31059 Toulouse, France. Electronic address:
Background: Pyriform sinus carcinomas (SCC) present specific functional and oncological issues. The recent advent of trans-oral robotic surgery (TORS), as a conservative procedure, has opened up new perspectives.
Objectives: To present the oncological and functional outcomes of TORS for pyriform sinus SCC. Read More
Oral Oncol 2018 Nov 21;86:132-140. Epub 2018 Sep 21.
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Objective: To evaluate OS and toxicity after definitive radiation with concurrent cetuximab (CTX-RT) compared to radiation with concurrent cytotoxic chemotherapy (CRT) in older HNSCC patients via the SEER-Medicare linked database.
Materials And Methods: We used the SEER-Medicare linked database to evaluate OS in HNSCC patients (Oropharynx, Larynx, Hypopharynx, Nasopharynx) diagnosed over 2005-2011, following FDA approval of cetuximab in combination with radiation therapy (RT) in March 2006.
Results: 2135 beneficiaries were identified. Read More
Radiat Oncol 2018 Nov 6;13(1):216. Epub 2018 Nov 6.
Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Background: A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and together with the platelet-to-lymphocyte ratio (PLR) is associated with worse outcomes in several solid tumors. We investigated the prognostic value of NLR and PLR in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary or adjuvant (chemo)radiotherapy ((C)RT).
Methods: A retrospective chart review of consecutive patients with HNSCC was performed. Read More
Cureus 2018 Jul 16;10(7):e2987. Epub 2018 Jul 16.
Radiation Oncology, Cross Cancer Center, University of Alberta, Edmonton, CAN.
Small cell carcinoma is rarely found to originate from the hypopharynx and there exists no treatment guidelines due to the small number of cases. Here, we present a case of a female patient with metastatic small cell carcinoma originating from the posterior hypopharynx with lymph node involvement. Her treatment consisted of chemotherapy with etoposide and cisplatin as well as radiation therapy. Read More
Sleep Med Clin 2018 Dec;13(4):549-558
Department of Surgery, Uniformed Services University, Bethesda, MD, USA; Department of Otolaryngology, University of Texas Health Sciences Center, San Antonio, TX, USA; Texas Facial Plastic Surgery and ENT, 14603 Huebner Road, Building 1, San Antonio, TX 78209, USA. Electronic address:
Multilevel surgery has been established as the mainstay of treatment for the surgical management of obstructive sleep apnea (OSA). Combined with uvulopalatopharyngoplasty, tongue-base surgeries, including the genioglossus advancement (GA), sliding genioplasty, and hyoid myotomy and suspension, have been developed to target hypopharyngeal obstruction. Total airway surgery consisting of maxillomandibular advancement (MMA) with/without GA has shown significant success. Read More