8,585 results match your criteria Hypoparathyroidism


Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019

Robotic transoral thyroidectomy: Total thyroidectomy and ipsilateral central neck dissection with da Vinci Xi Surgical System.

Head Neck 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Transoral approach for thyroidectomy draws attention recently among the thyroid surgeons, with the merits of cosmetic outcomes and minimal flap dissection. The aim of this study is to demonstrate the details and the steps of transoral robotic thyroidectomy.

Methods: We made three incisions in the gingival-buccal sulcus for three 8-mm intraoral ports: one inverted U-shaped 1-cm midline incision approximately 2 cm above the frenulum, and two 0. Read More

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http://dx.doi.org/10.1002/hed.25661DOI Listing
February 2019

Posterior reversible encephalopathy syndrome due to hypercalcaemia: a rare cause.

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2017-223415DOI Listing
February 2019
1 Read

New advances of ICG angiography in parathyroid identification.

Authors:
Hao Jin Min Cui

Endocr Metab Immune Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

The Second Department of General Surgery, Zhuhai People's Hospital, No. 79 of Kangning Road, Xiangzhou District, Zhuhai City, Guangdong Province, 519000. China.

Objective: For surgeons, locating the parathyroid in thyroidectomy and parathyroidectomy is critical since the parathyroid plays an important role in calcium balance. The fluorescence of the parathyroid has already been found by researchers and the angiography equipment detecting the fluorescence of the parathyroid with indocyanine green has been widely applied. Using the indocyanine green angiography and looking at the actual fluorescence of in vivo and in vitro tissues, it was possible to identify the thyroid, parathyroid, lymph nodes and fat tissues during the surgical procedure. Read More

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http://dx.doi.org/10.2174/1871530319666190206212456DOI Listing
February 2019
5 Reads

Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 5:194599819829052. Epub 2019 Feb 5.

1 Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.

Objective: The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies. Read More

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http://dx.doi.org/10.1177/0194599819829052DOI Listing
February 2019
1 Read

Parathyroid autotransplantation at a novel site for better evaluation of the grafted gland function: study protocol for a prospective, randomized controlled trial.

Trials 2019 Jan 31;20(1):96. Epub 2019 Jan 31.

Department of Thyroid and Breast Surgery, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, China.

Background: Hypoparathyroidism is one of the most common complications encountered in thyroidectomy. In addition to parathyroid in-situ preservation, parathyroid autotransplantation (PA) is another important remedial method for patients whose parathyroid glands have been removed. However, an accurate evaluation method for the function of a transplanted parathyroid is lacking. Read More

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http://dx.doi.org/10.1186/s13063-019-3195-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357396PMC
January 2019

[Application of carbon nano-particles in total thyroidectomy combined with lymphadenectomy in area Ⅵ].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):28-32

Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To evaluate the effects of staining with carbon nanoparticles on the identification of parathyroid glands and lymph nodes during thyroid carcinoma surgery combined with lymphadenectomy. A total of 194 patients with papillary thyroid carcinoma who underwent thyroidectomy combined with lymphadenectomy from April 2016 to January 2018 were reviewed. Of them 104 cases were injected with carbon nanoparticles in operation area (nanocarbon group) and other 90 cases without the injection of carbon nanoparticles were as control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.007DOI Listing
January 2019

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports.

Clin Diabetes Endocrinol 2019 22;5. Epub 2019 Jan 22.

1Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.

Background: Since 2011 six immune checkpoint inhibitors (ICI) have been approved to treat patients with many advanced solid tumor and hematological malignancies to improve their prognosis. Case reports of their endocrine immune-related adverse events [irAEs]) are increasingly published as more real-world patients with these malignancies are treated with these drugs. They alert physicians of a drug's AEs (which may change during a drug's life cycle) and contribute to post-marketing safety surveillance. Read More

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https://clindiabetesendo.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s40842-018-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343255PMC
January 2019
3 Reads

Scarless neck thyroidectomy using bilateral axillo-breast approach: Initial impressions after introduction in a specialized unit and a review of the literature.

Cir Esp 2019 Feb 26;97(2):81-88. Epub 2019 Jan 26.

Department of Surgery, Mount Sinai Hospital, New York, NY, USA.

Introduction: The extracervical approach for thyroidectomy remains widely unknown in our country. Its main aim is to avoid a cervical scar while maintaining the same safety profile of conventional thyroidectomy. The objective is to communicate our experience after the first 15 cases using the endoscopic bilateral axillo-breast approach (BABA) and to review critical points described in literature. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.11.006DOI Listing
February 2019
2 Reads

Clinical presentation and management of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):927-939. Epub 2018 Sep 28.

Department of Surgery and Translational Medicine, University of Florence, Bone Metabolic Diseases Unit, University Hospital of Florence, Italy. Electronic address:

The clinical manifestations of hypoparathyroidism are variable and can involve almost any organ system. The main clinical features of the hypoparathyroidism are typically signs or symptoms due to neuromuscular irritability owing to low serum calcium level. In addition to hypocalcemia, hyperphosphatemia can contribute to long-term complications, including extra-skeletal calcifications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183010
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http://dx.doi.org/10.1016/j.beem.2018.09.007DOI Listing
December 2018
3 Reads

Causes and pathophysiology of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 29;32(6):909-925. Epub 2018 Jul 29.

Department of Surgery and Translational Medicine, University of Florence, Bone Metabolic Diseases Unit, University Hospital of Florence, Italy. Electronic address:

Hypoparathyroidism, a disorder characterized by hypocalcemia ensuing from inadequate parathyroid hormone secretion, is a rather rare disorder caused by multiple etiologies. When not caused by inadvertent damage or removal of the parathyroids during neck surgery, it is usually genetically determined. Epidemiological figures of this disease are still scarce and mainly limited to countries where non-anonymous databases are available and to surgical case series. Read More

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http://dx.doi.org/10.1016/j.beem.2018.07.001DOI Listing
December 2018
1 Read

Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal nerve injury in adults undergoing thyroid surgery.

Cochrane Database Syst Rev 2019 Jan 19;1:CD012483. Epub 2019 Jan 19.

Department of General Surgery, University of Perugia, Terni, Italy, 05100.

Background: Injuries to the recurrent inferior laryngeal nerve (RILN) remain one of the major post-operative complications after thyroid and parathyroid surgery. Damage to this nerve can result in a temporary or permanent palsy, which is associated with vocal cord paresis or paralysis. Visual identification of the RILN is a common procedure to prevent nerve injury during thyroid and parathyroid surgery. Read More

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http://dx.doi.org/10.1002/14651858.CD012483.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353246PMC
January 2019
2 Reads

Evaluation of Parathyroid Glands with Indocyanine Green Fluorescence Angiography After Thyroidectomy.

World J Surg 2019 Jan 18. Epub 2019 Jan 18.

Division of Breast, Endocrine, Metabolic and Gastrointestinal Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA.

Background: Indocyanine green fluorescence angiography (ICGA) is a new adjunct that has been used in surgical procedures to assess blood flow. This study evaluated the utility of ICGA compared to visual inspection to predict parathyroid function, guide autotransplantation and potentially decrease permanent hypoparathyroidism.

Methods: This was a retrospective study of patients who underwent total or near-total thyroidectomy (T-NT) between January 2015 and March 2018. Read More

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http://dx.doi.org/10.1007/s00268-019-04909-zDOI Listing
January 2019
4 Reads

Effect of Endogenous Parathyroid Hormone on Bone Geometry and Skeletal Microarchitecture.

Calcif Tissue Int 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Parathyroid hormone (PTH) has anabolic or catabolic effects on bones; however, the skeletal effect of endogenous PTH on cortical and trabecular bones is not yet clear. Therefore, we aimed to examine the effects of an excess and a deficiency of endogenous PTH on the lumbar spine trabecular bone score (TBS) and bone geometry using dual-energy X-ray absorptiometry. We retrospectively included 70 patients with primary hyperparathyroidism (PHPT), 26 patients with idiopathic or postoperative hypoparathyroidism (HypoPT), and 96 normal controls matched by age, sex, and body mass index. Read More

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http://link.springer.com/10.1007/s00223-019-00517-0
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http://dx.doi.org/10.1007/s00223-019-00517-0DOI Listing
January 2019
6 Reads

Conventional Treatment of Hypoparathyroidism.

Front Horm Res 2019 19;51:160-164. Epub 2018 Nov 19.

The treatment of hypoparathyroidism depends on the severity of hypocalcemia, how rapidly the hypocalcemia developed, and the symptomatology. Chronic hypoparathyroidism is usually treated with oral supplementations, including calcium, calcitriol, or other active vitamin D analogs, and at times, thiazide diuretics. Although the standard therapy can adequately control patients with this disease, sometimes very high doses are required to maintain serum calcium levels in the normal range, with poor compliance and risk of long-term complications. Read More

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http://dx.doi.org/10.1159/000491046DOI Listing
November 2018
1 Read

A New Era for Chronic Management of Hypoparathyroidism: Parathyroid Hormone Peptides.

Front Horm Res 2019 19;51:165-171. Epub 2018 Nov 19.

Several studies have investigated replacement therapy with recombinant human parathyroid hormone [rhPTH(1-84)] for patients affected by chronic hypoparathyroidism who are not adequately controlled with standard treatment. In 2015, the Food and Drug Administration (FDA) in the USA approved rhPTH(1-84), named Natpara®, for the pharmacological management of hypoparathyroidism. In Europe, in February 2017, the European Medicines Agency (EMA) recommended granting a conditional marketing authorization in the European Union for rhPTH(1-84). Read More

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http://dx.doi.org/10.1159/000491047DOI Listing
November 2018
1 Read

Hypoparathyroidism.

Front Horm Res 2019 19;51:109-126. Epub 2018 Nov 19.

The regulation of plasma calcium levels is essential for the normal physiologic function of every cell. Parathyroid hormone (PTH) is the principal regulator of serum calcium and phosphate homeostasis. PTH is synthesized and secreted by the parathyroid chief cells in the parathyroid glands primarily in response to a decline in serum calcium levels. Read More

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http://dx.doi.org/10.1159/000491042DOI Listing
November 2018
1 Read

Clinical Presentation of Hypoparathyroidism.

Front Horm Res 2019 19;51:139-146. Epub 2018 Nov 19.

Parathyroid hormone (PTH) is one of the major hormones that regulates serum calcium. Hypoparathyroidism occurs when PTH secretion is insufficient. The main symptoms of hypoparathyroidism are the result of low blood calcium levels, hypocalcemia, which interferes with normal muscle contraction and nerve conduction. Read More

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http://dx.doi.org/10.1159/000491044DOI Listing
November 2018
1 Read

Classification of Hypoparathyroid Disorders.

Front Horm Res 2019 19;51:127-138. Epub 2018 Nov 19.

The term hypoparathyroidism encompasses a huge group of disorders all characterized by an abnormal mineral homeostasis determined by inadequate secretion of parathyroid hormone. Postsurgical hypoparathyroidism is a complication of neck surgery (thyroidectomy, parathyroidectomy, lymph node, and cancer neck dissection), closely related to the extent of the surgical procedure and the experience of the surgeon. If lasting more than 6 months it is defined as chronic hypoparathyroidism, requiring life-long replacement therapy with active vitamin D metabolites. Read More

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http://dx.doi.org/10.1159/000491043DOI Listing
November 2018
2 Reads

Additional Tunisian patients with Sanjad-Sakati syndrome: A review toward a consensus on diagnostic criteria.

Arch Pediatr 2019 Feb 10;26(2):102-107. Epub 2019 Jan 10.

Department of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Street ibn jazzar, 4000 Sousse, Tunisia.

Background And Objectives: Sanjad-Sakati syndrome (SSS; OMIM 241410) is a rare autosomal recessive disorder found almost exclusively in people of Arab origin. It is characterized by congenital hypoparathyroidism, severe prenatal and postnatal growth retardation, and distinct facial dysmorphism. The molecular pathology of this syndrome was shown to be due to a mutation in the tubulin-specific chaperone E (TBCE) gene in chromosomal area 1q42-q43. Read More

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http://dx.doi.org/10.1016/j.arcped.2018.11.012DOI Listing
February 2019

Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?

Langenbecks Arch Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of Endocrine Surgery, Catholic Hospital Mainz, An der Goldgrube 11, 55131, Mainz, Germany.

Importance: Postoperative hypoparathyroidism remains a relevant problem after thyroid surgery. Although the roles of vitamin D deficiency and other risk factors have been discussed in previous studies, variable results have been reported.

Objective: Predicting the risk of postoperative hypocalcemia could be helpful for individual prognoses and medical treatment. Read More

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http://dx.doi.org/10.1007/s00423-019-01748-3DOI Listing
January 2019
1 Read

Perioperative magnesium levels in total thyroidectomy and relationship to hypocalcemia.

Head Neck 2019 Jan 10. Epub 2019 Jan 10.

Department of Otolaryngology - Head & Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.

Background: We have previously shown an association between hypomagnesemia and hypocalcemia after thyroidectomy. However, little is known regarding the trend in magnesium levels in the days after thyroidectomy. Our objective was to study this trend in magnesium levels after thyroidectomy. Read More

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http://dx.doi.org/10.1002/hed.25644DOI Listing
January 2019
1 Read

Downregulation of genes outside the deleted region in individuals with 22q11.2 deletion syndrome.

Hum Genet 2019 Jan 9;138(1):93-103. Epub 2019 Jan 9.

Genetics Division, Universidade Federal de São Paulo, São Paulo, Brazil.

The 22q11.2 deletion syndrome (22q11.2DS) is caused by recurrent hemizygous deletions of chromosome 22q11. Read More

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http://link.springer.com/10.1007/s00439-018-01967-6
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http://dx.doi.org/10.1007/s00439-018-01967-6DOI Listing
January 2019
6 Reads

Auditing the efficacy and safety of alfacalcidol and calcium therapy in idiopathic hypoparathyroidism.

J Clin Endocrinol Metab 2019 Jan 3. Epub 2019 Jan 3.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi.

Context: Patients with hypoparathyroidism are managed with vitamin D and calcium. PTH is an emerging option due to its physiological action. Therefore, it is important to assess the efficacy and shortcomings of conventional therapy. Read More

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http://dx.doi.org/10.1210/jc.2018-02228DOI Listing
January 2019
2 Reads

The application of subcapsular saline injection during bilateral axillo-breast approach robotic thyroidectomy: a preliminary report.

Surg Today 2019 Jan 2. Epub 2019 Jan 2.

Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, South Korea.

Purpose: Saving the parathyroid gland during robotic thyroidectomy is challenging. This study evaluated the application of a novel method, subcapsular saline injection (SCASI), to save the parathyroid gland during bilateral axillo-breast approach (BABA) robotic total thyroidectomy.

Methods: Of the 81 included patients operated on from 2014 to 2016, 31 and 50 underwent BABA robotic total thyroidectomy with and without SCASI, respectively. Read More

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http://dx.doi.org/10.1007/s00595-018-1748-2DOI Listing
January 2019
1 Read
1.208 Impact Factor

Multiple impacted permanent teeth, an indicator for early detection of hypoparathyroidism: A rare case report.

J Family Med Prim Care 2018 Sep-Oct;7(5):1096-1099

Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India.

Eruption is a process of continuous movement of the developing tooth bud from its developmental location to functional location. Teeth that cease to erupt before emergence to their functional position in the oral cavity are termed as impactions. In permanent dentition, third molars are the most frequently impacted teeth followed by the canines. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_352_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259515PMC
January 2019
1 Read

Idiopathic Hypoparathyroidism and Severe Hypocalcemia in Pregnancy.

Case Rep Endocrinol 2018 27;2018:8316017. Epub 2018 Nov 27.

Department of Endocrinology, Rafic El Hariri University Hospital, Beirut, Lebanon.

The objective of this study is to report a case of severe hypocalcemia secondary to hypoparathyroidism in a pregnant woman. We report a case of a 45-year-old woman who presented for tonico-clonic seizure in the third trimester of gestation. She was diagnosed with idiopathic hypoparathyroidism for the first time during pregnancy. Read More

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http://dx.doi.org/10.1155/2018/8316017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288569PMC
November 2018
3 Reads

[ASBMR 2018 Topics.]

Authors:
Seiji Fukumoto

Clin Calcium 2019 ;29(1):121-124

The annual meeting of ASBMR was held in Montr?al Convention Center between September 28th and October 1st, 2018. Many scientific papers concerning bone, mineral metabolism, muscle and so on were presented as usual. There were several new attempts such as discussion about clinically difficult cases and sessions for young scientists in this meeting. Read More

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http://dx.doi.org/CliCa1901121124DOI Listing
January 2019

Cardiovascular findings in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism: A cohort study.

Clin Endocrinol (Oxf) 2018 Dec 27. Epub 2018 Dec 27.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: As only sparse data are available on indices of cardiovascular health among patients with nonsurgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP), we aimed to compare the cardiovascular profile between these groups of patients.

Methods: A total of 56 patients with Ns-HypoPT and 30 with PHP were included and underwent a clinical examination including blood sampling and measurements of arterial stiffness, pulse wave velocity (PWV) and blood pressure (BP). Arterial stiffness and PWV were measured using AtCor SphygmoCor-XCEL (Atcor Medical Pty Ltd, Sydney, NSW, Australia). Read More

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http://dx.doi.org/10.1111/cen.13927DOI Listing
December 2018
3 Reads

Research on indocyanine green angiography for predicting postoperative hypoparathyroidism.

Clin Endocrinol (Oxf) 2019 Mar 7;90(3):487-493. Epub 2019 Jan 7.

The Second Department of General Surgery, Zhuhai People's Hospital, Zhuhai City, Guangdong Province, China.

Background: It may be critical to locate the parathyroid for surgeons during thyroidectomy or parathyroidectomy due to the significant function of the parathyroid in calcium balance. According to recent reports, the intrinsic fluorescence of the parathyroid has been found. There is some evidence supporting that new equipment can detect fluorescence via imaging technology. Read More

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http://dx.doi.org/10.1111/cen.13925DOI Listing
March 2019
3 Reads

Technique for endoscopic thyroidectomy with selective lateral neck dissection via a chest-breast approach.

Surg Endosc 2018 Dec 19. Epub 2018 Dec 19.

Department of Thyroid Surgery, First People's Hospital of Zunyi, Zunyi, 563000, China.

Background: Endoscopic thyroidectomy has been widely accepted because it can effectively avoid neck scarring. However, there are seldom reports concerning completely endoscopic lateral neck dissection approaches. In this study, we introduced a technique for performing endoscopic thyroidectomy with lateral neck dissection via a chest-breast approach. Read More

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http://dx.doi.org/10.1007/s00464-018-06608-7DOI Listing
December 2018
3 Reads

Optic neuritis as presenting primary hypoparathyroidism.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Ophthalmology, Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster, UK.

Papilloedema and raised intracranial pressure have been frequently reported with hypoparathyroidism, but very rarely optic neuritis. We report a case of a 54-year-old male patient who presented with classical optic neuritis which is believed to be secondary to primary hypoparathyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2018-227032DOI Listing
November 2018

Epidemiology of parathyroid disorders.

Authors:
Sudhaker D Rao

Best Pract Res Clin Endocrinol Metab 2018 Dec 7;32(6):773-780. Epub 2018 Dec 7.

Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Bone & Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA. Electronic address:

Parathyroid disorders are not as uncommon as once believed. Both hyper- and hypoparathyroidism are more prevalent in women, but for different reasons. The female preponderance seen in primary hyperparathyroidism may be pathogenically linked, as it is more common after menopause. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183013
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http://dx.doi.org/10.1016/j.beem.2018.12.003DOI Listing
December 2018
11 Reads

Prevalence of growth and endocrine disorders in Malaysian children with transfusion-dependent thalassaemia.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia.

Methods: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Read More

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http://www.smj.org.sg/sites/default/files/OA-2016-339-epub.p
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http://dx.doi.org/10.11622/smedj.2018155DOI Listing
December 2018
7 Reads
0.634 Impact Factor

Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma.

Surgery 2018 Dec 13. Epub 2018 Dec 13.

Service of Endocrinology, University Hospital 12 de Octubre, Faculty of Medicine, University Complutense, Madrid, Spain; Research Institute i+12, University Hospital 12 de Octubre, Faculty of Medicine, University Complutense, Madrid, Spain. Electronic address:

Background: Although bone mineral density is reported to be increased in patients with postsurgical hypoparathyroidism (postsurgical HypoPT), the effect of HypoPT on trabecular bone score remains unknown. This study evaluated the long-term effects of HypoPT secondary to total thyroidectomy for differentiated thyroid cancer on trabecular bone score, bone mineral density, and bone turnover markers with a similar group of patients without HypoPT.

Methods: Women with resected differentiated thyroid cancer and either postsurgical HypoPT (n = 25; 8 premenopausal and 17 postmenopausal) or euparathyroid function (n = 98; 14 premenopausal and 84 postmenopausal) were matched for age and body mass index. Read More

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http://dx.doi.org/10.1016/j.surg.2018.10.034DOI Listing
December 2018
2 Reads

Management of velopharyngeal dysfunction in patients with 22q11.2 deletion syndrome: A survey of practice patterns.

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:43-48. Epub 2018 Oct 12.

The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Objective: To determine demographics and practice patterns of surgeons treating velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome (22q11.2DS). Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.10.016DOI Listing
January 2019
1 Read

Treatment of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 6;32(6):955-964. Epub 2018 Dec 6.

San Raffaele Vita Salute University, IRCCS San Raffaele Hospital, Milan, Italy. Electronic address:

The goal of the clinical management of hypoparathyroidism is to correct acute and chronic hypocalcemia. Treatment of acute hypoparathyroidism via intravenous infusion of Ca++ salts, is necessary only in symptomatic patients, or in asymptomatic patients in the setting of a rapid decrease in ionized Ca levels. The treatment cornerstones of chronic hypoparathyroidism are oral supplementation of calcium and/or active vitamin D, that can be associated with dietary restriction of sodium and phosphates, thiazide diuretics, and phosphate binders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183013
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http://dx.doi.org/10.1016/j.beem.2018.12.002DOI Listing
December 2018
14 Reads

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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http://dx.doi.org/10.1530/EJE-18-0609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365672PMC
December 2018
6 Reads

Increased risk of postoperative complications after total thyroidectomy with Graves' disease.

Head Neck 2019 Feb 7;41(2):281-285. Epub 2018 Dec 7.

Department of Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.

Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).

Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Read More

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http://dx.doi.org/10.1002/hed.25484DOI Listing
February 2019
2 Reads

A rare case of deafness and renal abnormalities in HDR syndrome caused by a de novo mutation in the GATA3 gene.

Genet Mol Biol 2018 Oct-Dec;41(4):794-798. Epub 2018 Nov 14.

Laboratório de Genética Molecular Humana, Centro de Engenharia Molecular e Genética, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.

HDR syndrome is a rare autosomal dominant disorder caused by mutations in the GATA3 gene and characterized by hypoparathyroidism, sensorineural deafness and renal abnormalities. Here we report a Brazilian family, from which the proband, his mother and his grandfather were diagnosed with bilateral sensorineural hearing loss. Molecular screening of the GJB2, GJB6 and MTRNR1 genes in the proband showed no alterations; however, whole exome sequencing detected a heterozygous mutation, c. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2017-0194DOI Listing
November 2018
1 Read

Early experience of transoral thyroidectomy: Comparison of robotic and endoscopic procedures.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

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http://doi.wiley.com/10.1002/hed.25426
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http://dx.doi.org/10.1002/hed.25426DOI Listing
December 2018
19 Reads

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283582PMC
December 2018
7 Reads

A Case of Seizure Revealing Fahr's Syndrome with Primary Hypoparathyroidism.

Am J Case Rep 2018 Dec 1;19:1430-1433. Epub 2018 Dec 1.

Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Idiopathic basal ganglia calcification, also known as Fahr's disease or Fahr's syndrome, is a rare neurological disorder characterized by abnormal calcified deposits in the basal ganglia. Here, we report a case of Fahr's syndrome with calcification of the basal ganglia due to hypoparathyroidism in a patient with seizures. CASE REPORT A 52-year-old male patient visited our clinic with seizures. Read More

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http://dx.doi.org/10.12659/AJCR.913382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287451PMC
December 2018
1 Read

Chronic Mucocutaneous Candidiasis in Autoimmune Polyendocrine Syndrome Type 1.

Front Immunol 2018 19;9:2570. Epub 2018 Nov 19.

Department Parasitology-Mycology, CHU, Lille, France.

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinoma (SCC), and may lead to death. The role of chronic infection in the etiopathogenesis of oral SCC is unclear. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02570
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http://dx.doi.org/10.3389/fimmu.2018.02570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254185PMC
November 2018
11 Reads

A new classification of parathyroid glands to evaluate in situ preservation or autotransplantation during thyroid surgery.

Medicine (Baltimore) 2018 Nov;97(48):e13231

Department of Thyroid Surgery,West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

The indication for autotransplantation of parathyroid glands is still controversial. A new classification of parathyroid glands based on the positional relationship among parathyroid glands, thyroid gland and thymus was created to decide in situ preservation or autotransplantation during thyroid surgery.A retrospective study included patients with papillary thyroid cancer who underwent total thyroidectomy with bilateral central lymph node dissection between November 2014 and November 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000013231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283141PMC
November 2018
1 Read

Bone Matrix Mineralization in Patients With Gain-of-Function Calcium-Sensing Receptor Mutations Is Distinctly Different From that in Postsurgical Hypoparathyroidism.

J Bone Miner Res 2018 Nov 29. Epub 2018 Nov 29.

Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of Social Health Insurance Vienna (WGKK) and Austrian Social Insurance for Occupational Risk (AUVA) Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.

The role of the calcium-sensing receptor (CaSR) as a regulator of parathyroid hormone secretion is well established, but its function in bone is less well defined. In an effort to elucidate the CaSR's skeletal role, bone tissue and material characteristics from patients with autosomal dominant hypocalcemia (ADH), a genetic form of primary hypoparathyroidism caused by CASR gain-of-function mutations, were compared to patients with postsurgical hypoparathyroidism (PSH). Bone structure and formation/resorption indices and mineralization density distribution (BMDD), were examined in transiliac biopsy samples from PSH (n = 13) and ADH (n = 6) patients by histomorphometry and quantitative backscatter electron imaging, respectively. Read More

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http://dx.doi.org/10.1002/jbmr.3638DOI Listing
November 2018
1 Read

Is there a need for an emergency card in hypoparathyroidism?

J Intern Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Background: Patients with hypoparathyroidism are at risk of both hypocalcemic and hypercalcemic crisis. Patients report that health professionals do not always respond adequately in an acute situation. The extent and handling of severe hypo- and hypercalcemia in hypoparathyroidism is unknown. Read More

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http://dx.doi.org/10.1111/joim.12865DOI Listing
November 2018
2 Reads

Application of indocyanine green in the parathyroid detection and protection: Report of 3 cases.

Am J Otolaryngol 2018 Nov 7. Epub 2018 Nov 7.

The Second Department of General Surgery, Zhuhai People's Hospital, No. 79 of Kangning Road, Xiangzhou District, Zhuhai City, Guangdong Province 519000, China. Electronic address:

Background: It was thought that identifying the parathyroid gland during surgery was difficult for surgeons. It may be critical to locate the parathyroid for surgeons during thyroidectomy or parathyroidectomy due to the significant function of the parathyroid in calcium balance. According to recent reports, intrinsic fluorescence of the parathyroid has been found. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.11.003DOI Listing
November 2018
2 Reads