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    Long-term outcome of prophylactic thyroidectomy in children carrying RET germline mutations.
    Br J Surg 2018 Jan;105(2):e150-e157
    Department of General, Visceral and Vascular Surgery, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
    Background: A comprehensive assessment has not been undertaken of long-term outcomes in children carrying germline RET mutations and undergoing prophylactic thyroidectomy with the aim of preventing medullary thyroid cancer (MTC).

    Methods: A retrospective outcome study (1994-2017) of prophylactic thyroidectomy in children, with and without central node dissection, was performed at a tertiary surgical centre.

    Results: Some 167 children underwent prophylactic thyroidectomy, 109 without and 58 with concomitant central node dissection. Read More

    Expanding indications of robotic thyroidectomy.
    Surg Endosc 2018 Jan 16. Epub 2018 Jan 16.
    Department of Surgery, Chung-Ang University Hospital and Chung-Ang University College of Medicine, 224-1, Heuk Seok-Dong, Dongjak-Ku, Seoul, 156-755, Republic of Korea.
    Background: Robotic thyroidectomy has many advantages with comparable oncologic safety over conventional open surgery in low-risk differentiated thyroid cancer cases. However, there have been few reports on the outcomes of patients who have been treated with robotic thyroidectomy for more advanced thyroid cancer. The aim of this study was to investigate the validity of expanding indications of robotic thyroidectomy for more advanced thyroid cancer. Read More

    The PGRIS and parathyroid splinting concepts for the analysis and prognosis of protracted hypoparathyroidism.
    Gland Surg 2017 Dec;6(Suppl 1):S86-S93
    Endocrine Surgery Unit, Hospital del Mar, Barcelona, Spain.
    Most patients with hypocalcemia after total thyroidectomy will recover the parathyroid function in a few weeks, but some 20-30% of them will still be in the need for replacement therapy one month after surgery and about 5-10% of those will develop permanent hypoparathyroidism. Although postoperative hypocalcemia has been related to several demographic and metabolic causes, parathyroid hormone (PTH) decline, resulting from autotransplantation, inadvertent excision or devascularization of the parathyroid glands, is the common final pathway. The number of parathyroid glands remaining in situ (PGRIS) is a key variable to understand the pathogenesis of protracted hypoparathyroidism and the chances for restoration of the parathyroid function. Read More

    Short and long-term impact of parathyroid autotransplantation on parathyroid function after total thyroidectomy.
    Gland Surg 2017 Dec;6(Suppl 1):S75-S85
    Endocrine Surgical Unit, University of Sydney, St Leonards, New South Wales, Australia.
    The most common complication of total thyroidectomy is parathyroid insufficiency. Acute, transient, post-operative hypoparathyroidism increases length of hospitalization, morbidity and cost associated with total thyroidectomy. While permanent hypoparathyroidism poses a significant medical burden with lifetime medication, regular follow up and considerable disease burden related to chronic renal failure and other sequelae. Read More

    Hypocalcaemia and permanent hypoparathyroidism after total/bilateral thyroidectomy in the BAETS Registry.
    Gland Surg 2017 Dec;6(Suppl 1):S69-S74
    Consultant Endocrine Surgeon, Nottingham University Hospitals, City Campus, Nottingham, UK.
    The UK Registry of Endocrine and Thyroid Surgeons (UKRETS) has been operated by the British Association of Endocrine and Thyroid Surgeons (BAETS) and Dendrite Clinical Systems Ltd. in a web-based electronic format since 2004. Data on over 90,000 endocrine procedures have been collected to date. Read More

    Incidence, prevalence and risk factors for post-surgical hypocalcaemia and hypoparathyroidism.
    Gland Surg 2017 Dec;6(Suppl 1):S59-S68
    Consultant Endocrine Surgeon, Endocrine Surgery Unit, Directorate of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Hypocalcaemia following thyroid surgery is common and is associated with significant short and long term morbidity. Damage to or devascularisation of parathyroid glands is the predominant underlying mechanism; although other factors such as hungry bone syndrome may occasionally contribute to it in the immediate post-operative period. The reported incidence of post-surgical hypocalcaemia and/or hypoparathyroidism (PoSH) varies significantly in the literature; the variation thought to be at least partly due to differences in the definitions used. Read More

    Less than total thyroidectomy for goiter: when and how?
    Gland Surg 2017 Dec;6(Suppl 1):S49-S58
    Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital, Izmir, Turkey.
    Benign goiter is the most common endocrine disease that requires surgery, especially in endemic areas suffering from iodine-deficiency. Recent European and American guidelines recommended total thyroidectomy for the surgical treatment of multinodular goiter. Total thyroidectomy has now become the technique of choice and is widely considered the most reliable approach in preventing recurrence. Read More

    The role and timing of parathyroid hormone determination after total thyroidectomy.
    Gland Surg 2017 Dec;6(Suppl 1):S38-S48
    Section of Endocrine Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
    Postoperative hypocalcemia is a common complication of total thyroidectomy resulting from manipulation, resection, or devascularization of the parathyroid glands. Parathyroid hormone (PTH) levels assessed in the perioperative period have been used to predict development of hypocalcemia. Articles examining the role of PTH measurement in the perioperative period following total or completion thyroidectomy are reviewed. Read More

    A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques.
    Gland Surg 2017 Dec;6(Suppl 1):S30-S37
    Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland.
    Identification of the parathyroid glands (PGs) during thyroid surgery may prevent their inadvertent surgical removal and prevent postoperative hypoparathyroidism. However, identification of the PGs does not guarantee their function, and their vascular supply needs to be preserved as well. The recent introduction of intraoperative indocyanine green (ICG) fluorescent angiography of the PGs during thyroid surgery allows for the appraisal of the vascular anatomy and evaluation of PG function. Read More

    To identify or not to identify parathyroid glands during total thyroidectomy.
    Gland Surg 2017 Dec;6(Suppl 1):S20-S29
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
    Hypoparathyroidism is one of the most common complications after total thyroidectomy and may impose a significant burden to both the patient and clinician. The extent of thyroid resection, surgical techniques, concomitant central neck dissection, parathyroid gland (PG) autotransplantation and inadvertent parathyroidectomy have long been some of the risk factors for postoperative hypoparathyroidism. Although routine identification of PGs has traditionally been advocated by surgeons, recent evidence has suggested that perhaps identifying fewer number of in situ PGs during surgery (i. Read More

    A nomogram to predict the likelihood of permanent hypoparathyroidism after total thyroidectomy based on delayed serum calcium and iPTH measurements.
    Gland Surg 2017 Dec;6(Suppl 1):S11-S19
    Endocrine Surgery Unit, University Hospital del Mar, Barcelona, Spain.
    Background: Retrospective studies have shown that delayed high-normal serum calcium and detectable iPTH are independent variables positively influencing outcome of prolonged parathyroid failure after total thyroidectomy (TT). The aim of the present study was to examine prospectively the ability of these two variables to predict permanent hypoparathyroidism in patients under replacement therapy for postoperative hypocalcemia.

    Methods: Prospective observational multicenter study of patients undergoing TT followed by postoperative parathyroid failure (serum calcium <8 mg/dL within 24 h and PTH <15 pg/mL 4 h after surgery). Read More

    Clinical profile and long-term follow-up of 32 patients with postoperative permanent hypoparathyroidism.
    Gland Surg 2017 Dec;6(Suppl 1):S3-S10
    Endocrine Surgery Unit, Hospital del Mar, Barcelona, Spain.
    Background: Parathyroid failure is the most common complication after total thyroidectomy but permanent impairment of the parathyroid function is unusual. Limited data is available assessing long-term follow-up, quality of life and complications occurring in patients with permanent hypoparathyroidism (PH). We aimed to assess the incidence of complications derived from PH status, their influence on the quality of life perceived by PH patients and its relation to standard medical treatment with calcium salts and active vitamin D analogues. Read More

    Does Surgery Without Lugol's Solution Pretreatment for Graves' Disease Increase Surgical Morbidity?
    World J Surg 2018 Jan 4. Epub 2018 Jan 4.
    The Department of Digestive and Endocrine Surgery, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, 165 Chemin du Grand Revoyet, 69495, Pierre Bénite, France.
    Background: Total thyroidectomy can be performed for Graves' disease after a euthyroid state is achieved using inhibitors of thyroid hormone synthesis (thioamides). However, hypervascularization of the thyroid gland is associated with increased hemorrhage risk, in addition to complicating identification of the recurrent laryngeal nerve and parathyroid gland. Saturated iodine solution (Lugol's solution) has been recommended to reduce thyroid gland hypervascularization and intraoperative blood loss, although this approach is not used at our center based on our experience that it induces thyroid firmness and potentially hypoparathyroidism. Read More

    Effect of autotransplantation of a parathyroid gland on hypoparathyroidism after total thyroidectomy.
    Endocr Connect 2018 Jan 4. Epub 2018 Jan 4.
    J Zhu, Chengdou, 610041, China
    Background: The effect of parathyroid autotransplantation on hypoparathyroidism is not fully understood. The purpose of the study was to determine the effect of autotransplantation of a parathyroid gland on the incidence of hypoparathyroidism and recovery of parathyroid function at 6 months after total thyroidectomy with central neck dissection for papillary thyroid carcinoma.

    Methods: All patients with autotransplantation of a parathyroid gland (no inadvertent parathyroidectomy) (group A), in situ preservation of all parathyroid glands (no autotransplantation and inadvertent parathyroidectomy) (group B), or inadvertent removal of a parathyroid gland (no autotransplantation) (group C) who underwent first-time total thyroidectomy with central neck dissection for papillary thyroid carcinoma between January 2013 and June 2016 were included retrospectively. Read More

    Transcription factors that determine parathyroid development power PTH expression.
    Kidney Int 2018 Jan;93(1):7-9
    Hadassah Hebrew University Medical Center, Jerusalem, Ein Karem, Israel.
    Studies in patients with hypoparathyroidism and knockout mouse models have revealed key transcriptional cascades central for parathyroid organogenesis. Among the transcription factors essential for parathyroid development, Gata3, GCM2, and MafB, are expressed in the developing parathyroids as well as postnatally, implying that they also regulate parathyroid-specific gene expression and function in the adult. PTH gene expression is determined by transcriptional and posttranscriptional mechanisms. Read More

    Congenital respiratory tract disorders in 22q11.2 deletion syndrome.
    Int J Pediatr Otorhinolaryngol 2018 Jan 20;104:1-4. Epub 2017 Oct 20.
    Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, The Netherlands; Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
    Objective: Respiratory tract disorders have been reported in patients with 22q11.2 deletion syndrome, however infrequently. This study describes the respiratory tract disorders encountered in a cohort of 278 patients with 22q11. Read More

    Pilot study of parathyroid glands in adult and pediatric subjects exposed to ionizing radiation after the ChNPP accident, methodology of parathyroid diagnostic ultrasound.
    Probl Radiac Med Radiobiol 2017 Dec;22:382-394
    State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine.
    Objective: Estimation of the parathyroid hyperplasia prevalence after the ChNPP accident in adults exposed to ion izing radiation and their descendants using the diagnostic ultrasound and its methodology elaboration.

    Materials And Methods: The pilot prospective study of the prevalence of parathyroid hyperplasia among the Chornobyl Nuclear Power Plant (ChNPP) accident adult survivors (n=686) and their descendants (54 children) was performed using diagnostic ultrasound examination of thyroid and parathyroids. Among the study subjects there were 339 ChNPP accident clean up workers (ACUW), 32 persons were evacuated from the 30 km exclusion zone and 224 ones were included to the control group. Read More

    Long-term complications in patients with hypoparathyroidism evaluated by biochemical findings - a case-control study.
    J Bone Miner Res 2017 Dec 27. Epub 2017 Dec 27.
    Dept. of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark.
    Hypoparathyroidism is associated with an increased risk of various complications, but only few data are available on risk factors. Using a case-control design, we assessed associations between biochemical findings and risk of different complications within a subpopulation of our previously identified Danish patients. We retrieved all biochemical data available on 431 (81% women) patients from the Central Region of Denmark, covering approximately 20% of the Danish population. Read More

    Hypoparathyroidism: what is the best calcium carbonate supplementation intake form?
    Braz J Otorhinolaryngol 2017 Nov 15. Epub 2017 Nov 15.
    Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Faculdade de Medicina de Botucatu, Departamento de Medicina Interna, Botucatu, SP, Brazil. Electronic address:
    Introduction: In hypoparathyroidism, calcium supplementation using calcium carbonate is necessary for the hypocalcemia control. The best calcium carbonate intake form is unknown, be it associated with feeding, juice or in fasting.

    Objective: The objective was to evaluate the calcium, phosphorus and Calcium×Phosphorus product serum levels of hypoparathyroidism women after total thyroidectomy, following calcium carbonate intake in three different forms. Read More

    [Gasless endoscopic selective lateral neck dissection via an anterior chest approach for papillary thyroid carcinomas].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;52(12):915-920
    Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510289, China.
    Objective: To assess the safety and curative effect of gasless endoscopic selective lateral neck dissection (GESLND) via an anterior chest approach for papillary thyroid carcinoma (PTC). Methods: Eighteen patients with PTC(T1-2N1bM0, size<3.0 cm), having GESLND via an anterior chest approach, were included from November 2008 to December 2016. Read More

    Comparative analysis of 2 robotic thyroidectomy procedures: Transoral versus bilateral axillo-breast approach.
    Head Neck 2017 Dec 14. Epub 2017 Dec 14.
    Department of Otolaryngology - Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Background: The surgical outcomes of a single surgeon's initial cases of transoral robotic thyroidectomy (TORT) were compared with the surgeon's initial cases of a bilateral axillo-breast approach (BABA) robotic thyroidectomy.

    Methods: The medical reports were retrospectively reviewed. The BABA robotic thyroidectomies were performed between 2008 and 2009, and TORTs were performed between 2012 and 2016. Read More

    Bone Mineral Density and Its Serial Changes Are Associated With PTH Levels in Pseudohypoparathyroidism Type 1B Patients.
    J Bone Miner Res 2017 Dec 14. Epub 2017 Dec 14.
    Department of Endocrinology, Key Laboratory of Endocrinology of National Health and Family Planning Commission, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS), Beijing, China.
    Bone responsiveness to serum parathyroid hormone (PTH) in pseudohypoparathyroidism 1B (PHP1B) is controversial. Forty-eight PHP1B patients diagnosed by molecular analysis were recruited from 2000 to 2016 from the Peking Union Medical College Hospital. Fifty-five sex-matched nonsurgical hypoparathyroidism (NS-HP) patients were selected and included for comparison. Read More

    Etelcalcetide: injectable calcimimetic for the treatment of secondary hyperparathyroidism in hemodialysis-dependent patients.
    Drugs Today (Barc) 2017 Sep;53(9):489-500
    INSERM U1132 and USPC Paris-Diderot, Department of Rheumatology, Hôpital Lariboisière, Paris, France.
    Chronic kidney disease is associated with mineral and bone disorders that are now considered as a syndrome. One of the major complications of this syndrome is secondary hyperparathyroidism (SHPT). SHPT increases bone turnover and the risk of fracture. Read More

    Post-thyroidectomy hypoparathyroidism, what should we keep in mind?
    Ann Ital Chir 2017 ;6:371-381
    Aim: Hypoparathyroidism and the resulting hypocalcemia is a common iatrogenic complication following surgical procedures to the neck, and commonly, to the thyroid gland. The aim of this study was to review the available literature to summarize current data related to the development of hypoparathyroidism after thyroid surgery.

    Materials And Methods: An analysis of the surgical literature was performed using the search engine EMBASE and PubMed with particular reference to the principal risk factors related to the post-thyroid surgery hypoparathyroidism. Read More

    The dental manifestations and orthodontic implications of hypoparathyroidism in childhood.
    J Orthod 2017 Nov 30:1-5. Epub 2017 Nov 30.
    a a Department of Orthodontics , University Dental Hospital of Manchester , Manchester , UK.
    The presence of short dental roots can present challenges to the orthodontist both in terms of identifying its aetiology and in subsequent treatment planning. Uncommon causes include hypoparathyroidism and pseudohypoparathyroidism, where short roots may be seen in combination with other oral manifestations including enamel hypoplasia secondary to low calcium levels. This case report highlights these features and the orthodontic treatment proposed. Read More

    Thyroid gland hemorrhage after blunt neck trauma: case report and review of the literature.
    BMC Surg 2017 Nov 28;17(1):115. Epub 2017 Nov 28.
    Department Surgery, Division of General and Visceral Surgery, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
    Background: Thyroid hemorrhage is considered to be an uncommon complication following blunt trauma to the neck. This condition is potentially life-threatening due to airway compression and may therefore require emergency airway management and surgical intervention in some cases.

    Case Presentation: We present the case of a 52-year-old woman who experienced a traumatic thyroid gland rupture (right lobe) with subsequent active arterial bleeding from branches of the inferior thyroid artery. Read More

    Risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy: a retrospective Chinese population study.
    Cancer Manag Res 2017 15;9:627-635. Epub 2017 Nov 15.
    Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
    Background: Hypocalcemia is one of the most common postoperative complications following thyroid surgery in clinical practice. The occurrence of hypocalcemia is mainly attributed to hypoparathyroidism when parathyroid glands are devascularized, injured, or dissected during the surgery. The aim of this study was to analyze the risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy. Read More

    [Recombinant human parathyroid hormone in the therapy of hypoparathyroidism].
    Ter Arkh 2017 ;89(10):80-86
    Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
    Hypoparathyroidism is an endocrine disease that results from deficiency or complete absence of parathyroid hormone (PTH), a biologically active 84-amino acid polypeptide. Standard therapy for chronic hypoparathyroidism includes oral calcium salts and active vitamin D metabolites and is aimed at maintaining a balance between optimal near-normal serum calcium concentration and normocalcuria. Traditional treatment regimens not always lead to the compensation for calcium and phosphorus metabolism. Read More

    Ann Endocrinol (Paris) 2017 Oct;78 Suppl 1:S1-S10
    Service d'endocrinologie, diabétologie, nutrition, hôpital Nord, CHU-UPJV d'Amiens, Amiens, France.
    Parathormone (PTH), produced by parathyroid glands, is the main regulator of calcium homeostasis. Hypoparathyroidism (hypoPT), due to decrease of PTH production, is a rare disease. Symptoms are multiple, altering function of several organs and leading to a decrease of quality of life. Read More

    In situ preservation of parathyroid glands:advanced surgical tips for prevention of permanent hypoparathyroidism in thyroid surgery.
    J BUON 2017 Jul-Aug;22(4):853-855
    Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
    Hypoparathyroidism (HPT) is one of the most frequentand severe complications of thyroid surgery. It is caused by intraoperative damage, devascularization or accidental removal of the parathyroid glands (PTGs). The incidence of postoperative HPT is directly proportional to surgery extent and surgeon's experience. Read More

    Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study.
    BMC Endocr Disord 2017 Nov 17;17(1):71. Epub 2017 Nov 17.
    Grupo de Estudo da Insulino-Resistência, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo, Lisboa, Portugal.
    Background: Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. Read More

    Is hungry bone syndrome a cause of postoperative hypocalcemia after total thyroidectomy in thyrotoxicosis? A prospective study with bone mineral density correlation.
    Surgery 2017 Nov 14. Epub 2017 Nov 14.
    Department of Endocrine Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.
    Background: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. Read More

    PARATHYROID FUNCTION AFTER TOTAL THYROIDECTOMY: A RANDOMIZED CLINICAL TRIAL CONCERNING THE INFLUENCE OF THE SURGICAL TECHNIQUE.
    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: 1Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcaemia. This study is prospective and evaluates the PTH function in non-clinically symptomatic patients after total thyroidectomy performed by two different techniques. Materials and Methods Prospective randomized clinical trial including 269 patients undergoing classic (group A) or harmonic scalpel (group B) total thyroidectomy. Read More

    Parathyroid transplantation in thyroid surgery.
    Gland Surg 2017 Oct;6(5):530-536
    Department of General, Vascular and Transplantation Surgery, the Medical University of Warsaw, Warsaw, Poland.
    Permanent hypoparathyroidism following thyroid surgery is rare. Its prevalence is reported to be below 1-2% if surgery is performed by experienced thyroid surgeons. Parathyroid identification and preservation in situ with good vascular supply is the mainstay of safe thyroid surgery. Read More

    Quantifying indices of short- and long-range white matter connectivity at each cortical vertex.
    PLoS One 2017 15;12(11):e0187493. Epub 2017 Nov 15.
    Developmental Imaging and Psychopathology Laboratory, University of Geneva School of medicine, Geneva, Switzerland.
    Several neurodevelopmental diseases are characterized by impairments in cortical morphology along with altered white matter connectivity. However, the relationship between these two measures is not yet clear. In this study, we propose a novel methodology to compute and display metrics of white matter connectivity at each cortical point. Read More

    Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism.
    Nephron 2017 Nov 9. Epub 2017 Nov 9.
    Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, Kentucky, USA.
    Background: In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown. The present study aims at evaluating the relationship of ioPTH with long-term PTH levels post-PTX in dialysis and renal transplant patients in a single-center study.

    Methods: The ioPTH was measured in 57 dialysis patients (33 females and 24 males) and 18 renal transplant recipients (12 males and 6 females) who underwent PTX from 2005 to 2015 for refractory HPT. Read More

    Risk factors for hypocalcaemia after completion hemithyroidectomy in thyroid cancer.
    Swiss Med Wkly 2017 Nov 9;147:w14513. Epub 2017 Nov 9.
    Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Luzern, Switzerland.
    Background: Hypocalcaemia (HC) is the most common complication after thyroid surgery in differentiated thyroid cancer and leads to a prolongation of the hospital stay. While risk factors for HC after total thyroidectomy (TE) are well investigated, only few studies have been published about HC risk factors after completion of thyroidectomy. Our aim was to identify potential risk factors for HC after completion of TE and to compare these incidences with figures from primary total TE. Read More

    Familial Hypocalciuric Hypercalcemia as an Atypical Form of Primary Hyperparathyroidism.
    J Bone Miner Res 2018 Jan 11;33(1):27-31. Epub 2017 Dec 11.
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
    Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia with features that overlap with typical primary hyperparathyroidism (PHPT). The incompleteness of this overlap has led to divergent nomenclatures for FHH. I compare two nomenclatures. Read More

    The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).
    Autoimmun Rev 2018 Jan 4;17(1):78-85. Epub 2017 Nov 4.
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address:
    Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential dysfunction of multiple endocrine or non-endocrine glands. A clinical diagnosis of APS-1 is typically based on the presence of at least two of three following criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. The first identified causative mutated gene for APS-1 is autoimmune regulator (AIRE) encoding a critical transcription factor, which is primarily expressed in the medullary thymic epithelial cells (mTECs) for generating central immune tolerance. Read More

    Impact of potassium iodide on thyroidectomy for Graves' disease: Implications for safety and operative difficulty.
    Surgery 2018 Jan 3;163(1):68-72. Epub 2017 Nov 3.
    Department of Surgery, University of Wisconsin, Madison, WI.
    Background: Potassium iodide often is prescribed prior to thyroidectomy for Graves' disease, but the effect of potassium iodide on the ease and safety of thyroidectomy for Graves' is largely unknown.

    Methods: We conducted a prospective, cohort study of patients with Graves' disease undergoing thyroidectomy. For the first 8 months, no patients received potassium iodide; for the next 8 months, potassium iodide was added to the preoperative protocol for all patients. Read More

    MIVAT: the last 2 years experience, tips and techniques after more than 10 years.
    Surg Endosc 2017 Nov 3. Epub 2017 Nov 3.
    Division of Week and Day Surgery, Department of Surgery, Sant'Andrea Hospital, II Faculty of Medicine and Surgery, Sapienza University, Rome, Italy.
    Background: Minimally invasive video-assisted thyroidectomy (MIVAT) has been introduced into clinical practice by Miccoli in the late 1990s (Miccoli et al., Am J Surg 181(6):567-570, 2001) and it has become a widespread technique used and welcomed worldwide. In this paper, we present our experience of the last 2 years; we also describe tips and techniques derived from over 460 cases performed in the last 10 years by the same surgical team with the same single operator. Read More

    Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism.
    J Clin Endocrinol Metab 2017 Nov 1. Epub 2017 Nov 1.
    Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
    Context: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism on conventional therapy with calcium and active vitamin D supplements.

    Objective: To examine the effects of recombinant human parathyroid hormone (rhPTH[1-84]) on HRQoL as measured by the 36-Item Short Form Health Survey (SF-36) during the multinational, randomized, placebo-controlled REPLACE study.

    Patients: 122 adults with chronic hypoparathyroidism. Read More

    PTH(1-34) for Surgical Hypoparathyroidism: A 2-Year Prospective, Open-Label Investigation of Efficacy and Quality of Life.
    J Clin Endocrinol Metab 2018 Jan;103(1):271-280
    Department of Endocrinology and Diabetes, Santa Maria della Misericordia Hospital, Udine, Italy.
    Context: Daily parathyroid hormone (PTH) (1-34) administrations can reduce the required total daily dose of calcium and calcitriol and restore normocalcemia in refractory hypoparathyroidism. However, most PTH(1-34) trials have been conducted on small cohorts including subjects with hypoparathyroidism of various etiologies, and quality of life (QOL) was not investigated.

    Objective: To investigate the effects of 24-month PTH(1-34) treatment in a homogeneous cohort of adult subjects with postoperative hypoparathyroidism and to evaluate QOL changes. Read More

    Carbon nanoparticles facilitate lymph nodes dissection and parathyroid glands identification in reoperation of papillary thyroid cancer.
    Medicine (Baltimore) 2017 Nov;96(44):e8380
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    The aim of the study was to investigate whether carbon nanoparticles (CNs) can improve the dissection of lymph nodes and protect parathyroid glands (PGs) during reoperation for patients with papillary thyroid carcinoma (PTC).PTC patients who previously underwent thyroidectomy and later received reoperation between January 2009 and January 2016 were retrospectively recruited. We compared the patients who had CN suspension injected into the residual thyroid gland with a control group of patients who did not have the injection. Read More

    Intraoperative Assessment of Parathyroid Viability using Laser Speckle Contrast Imaging.
    Sci Rep 2017 Nov 1;7(1):14798. Epub 2017 Nov 1.
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
    Post-surgical hypoparathyroidism and hypocalcemia are known to occur after nearly 50% of all thyroid surgeries as a result of accidental disruption of blood supply to healthy parathyroid glands, which are responsible for regulating calcium. However, there are currently no clinical methods for accurately identifying compromised glands and the surgeon relies on visual assessment alone to determine if any gland(s) should be excised and auto-transplanted. Here, we present Laser Speckle Contrast Imaging (LSCI) for real-time assessment of parathyroid viability. Read More

    A Population-Based Study of the Epidemiology of Chronic Hypoparathyroidism.
    J Bone Miner Res 2017 Oct 31. Epub 2017 Oct 31.
    Department of Medicine, University of Dundee, Dundee, UK.
    There are very few reports on the epidemiology of chronic hypoparathyroidism. A population-based study was undertaken to describe the prevalence and incidence of hypoparathyroidism in Tayside, Scotland. Data on biochemistry, hospital admissions, prescribing, and death records in Tayside, Scotland, from 1988 to 2015 were linked electronically. Read More

    Bone Status Among Patients With Nonsurgical Hypoparathyroidism, Autosomal Dominant Hypocalcaemia, and Pseudohypoparathyroidism: A Cohort Study.
    J Bone Miner Res 2017 Oct 31. Epub 2017 Oct 31.
    Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), Aarhus University Hospital, Aarhus, Denmark.
    Nonsurgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP) are both rare diseases, characterized by hypocalcemia. In Ns-HypoPT, PTH levels are low, whereas patients with PHP often have very high levels due to receptor-insensitivity to PTH (PTH-resistance). Accordingly, we hypothesized that indices of bone turnover and bone mineralization/architecture are similar in Ns-HypoPT and PHP despite marked differences in PTH levels. Read More

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