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    1 OF 163

    Is hungry bone syndrome a cause of postoperative hypocalcemia after total thyroidectomy in thyrotoxicosis? A prospective study with bone mineral density correlation.
    Surgery 2017 Nov 14. Epub 2017 Nov 14.
    Department of Endocrine Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.
    Background: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. Read More

    PARATHYROID FUNCTION AFTER TOTAL THYROIDECTOMY: A RANDOMIZED CLINICAL TRIAL CONCERNING THE INFLUENCE OF THE SURGICAL TECHNIQUE.
    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: 1Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcaemia. This study is prospective and evaluates the PTH function in non-clinically symptomatic patients after total thyroidectomy performed by two different techniques. Materials and Methods Prospective randomized clinical trial including 269 patients undergoing classic (group A) or harmonic scalpel (group B) total thyroidectomy. Read More

    Parathyroid transplantation in thyroid surgery.
    Gland Surg 2017 Oct;6(5):530-536
    Department of General, Vascular and Transplantation Surgery, the Medical University of Warsaw, Warsaw, Poland.
    Permanent hypoparathyroidism following thyroid surgery is rare. Its prevalence is reported to be below 1-2% if surgery is performed by experienced thyroid surgeons. Parathyroid identification and preservation in situ with good vascular supply is the mainstay of safe thyroid surgery. Read More

    Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism.
    Nephron 2017 Nov 9. Epub 2017 Nov 9.
    Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, Kentucky, USA.
    Background: In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown. The present study aims at evaluating the relationship of ioPTH with long-term PTH levels post-PTX in dialysis and renal transplant patients in a single-center study.

    Methods: The ioPTH was measured in 57 dialysis patients (33 females and 24 males) and 18 renal transplant recipients (12 males and 6 females) who underwent PTX from 2005 to 2015 for refractory HPT. Read More

    Risk factors for hypocalcaemia after completion hemithyroidectomy in thyroid cancer.
    Swiss Med Wkly 2017 Nov 9;147:w14513. Epub 2017 Nov 9.
    Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Luzern, Switzerland.
    Background: Hypocalcaemia (HC) is the most common complication after thyroid surgery in differentiated thyroid cancer and leads to a prolongation of the hospital stay. While risk factors for HC after total thyroidectomy (TE) are well investigated, only few studies have been published about HC risk factors after completion of thyroidectomy. Our aim was to identify potential risk factors for HC after completion of TE and to compare these incidences with figures from primary total TE. Read More

    Familial Hypocalciuric Hypercalcemia as an Atypical Form of Primary Hyperparathyroidism.
    J Bone Miner Res 2017 Nov 8. Epub 2017 Nov 8.
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda Md 20892.
    Introduction Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia with features that overlap with typical primary hyperparathyroidism (PHPT). The incompleteness of this overlap has led to divergent nomenclatures for FHH. I compare two nomenclatures. Read More

    The Immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address:
    Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential dysfunction of multiple endocrine or non-endocrine glands. A clinical diagnosis of APS-1 is typically based on the presence of at least two of three following criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. The first identified causative mutated gene for APS-1 is autoimmune regulator (AIRE) encoding a critical transcription factor, which is primarily expressed in the medullary thymic epithelial cells (mTECs) for generating central immune tolerance. Read More

    Impact of potassium iodide on thyroidectomy for Graves' disease: Implications for safety and operative difficulty.
    Surgery 2017 Nov 3. Epub 2017 Nov 3.
    Department of Surgery, University of Wisconsin, Madison, WI.
    Background: Potassium iodide often is prescribed prior to thyroidectomy for Graves' disease, but the effect of potassium iodide on the ease and safety of thyroidectomy for Graves' is largely unknown.

    Methods: We conducted a prospective, cohort study of patients with Graves' disease undergoing thyroidectomy. For the first 8 months, no patients received potassium iodide; for the next 8 months, potassium iodide was added to the preoperative protocol for all patients. Read More

    MIVAT: the last 2 years experience, tips and techniques after more than 10 years.
    Surg Endosc 2017 Nov 3. Epub 2017 Nov 3.
    Division of Week and Day Surgery, Department of Surgery, Sant'Andrea Hospital, II Faculty of Medicine and Surgery, Sapienza University, Rome, Italy.
    Background: Minimally invasive video-assisted thyroidectomy (MIVAT) has been introduced into clinical practice by Miccoli in the late 1990s (Miccoli et al., Am J Surg 181(6):567-570, 2001) and it has become a widespread technique used and welcomed worldwide. In this paper, we present our experience of the last 2 years; we also describe tips and techniques derived from over 460 cases performed in the last 10 years by the same surgical team with the same single operator. Read More

    Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism.
    J Clin Endocrinol Metab 2017 Nov 1. Epub 2017 Nov 1.
    Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
    Context: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism on conventional therapy with calcium and active vitamin D supplements.

    Objective: To examine the effects of recombinant human parathyroid hormone (rhPTH[1-84]) on HRQoL as measured by the 36-Item Short Form Health Survey (SF-36) during the multinational, randomized, placebo-controlled REPLACE study.

    Patients: 122 adults with chronic hypoparathyroidism. Read More

    PTH(1-34) for Surgical Hypoparathyroidism: A 2 year Prospective, Open-Label Investigation of Efficacy and Quality of Life.
    J Clin Endocrinol Metab 2017 Nov 1. Epub 2017 Nov 1.
    Department of Endocrinology and Diabetes, Santa Maria della Misericordia Hospital, 33100 Udine, Italy.
    Context: Daily PTH(1-34) administrations can reduce the required total daily dose of calcium/calcitriol and restore normocalcemia in refractory hypoparathyroidism. However, most of the PTH(1-34) trials were conducted on small cohorts including subjects with hypoparathyroidism of various etiologies and quality of life(QOL) was not investigated.

    Objective: To investigate the effects of 24 month PTH(1-34) treatment in a homogeneous cohort of adult subjects with postoperative hypoparathyroidism and to evaluate quality of life(QOL) changes. Read More

    Carbon nanoparticles facilitate lymph nodes dissection and parathyroid glands identification in reoperation of papillary thyroid cancer.
    Medicine (Baltimore) 2017 Nov;96(44):e8380
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    The aim of the study was to investigate whether carbon nanoparticles (CNs) can improve the dissection of lymph nodes and protect parathyroid glands (PGs) during reoperation for patients with papillary thyroid carcinoma (PTC).PTC patients who previously underwent thyroidectomy and later received reoperation between January 2009 and January 2016 were retrospectively recruited. We compared the patients who had CN suspension injected into the residual thyroid gland with a control group of patients who did not have the injection. Read More

    Intraoperative Assessment of Parathyroid Viability using Laser Speckle Contrast Imaging.
    Sci Rep 2017 Nov 1;7(1):14798. Epub 2017 Nov 1.
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
    Post-surgical hypoparathyroidism and hypocalcemia are known to occur after nearly 50% of all thyroid surgeries as a result of accidental disruption of blood supply to healthy parathyroid glands, which are responsible for regulating calcium. However, there are currently no clinical methods for accurately identifying compromised glands and the surgeon relies on visual assessment alone to determine if any gland(s) should be excised and auto-transplanted. Here, we present Laser Speckle Contrast Imaging (LSCI) for real-time assessment of parathyroid viability. Read More

    A Population-based study of the Epidemiology of Chronic Hypoparathyroidism.
    J Bone Miner Res 2017 Oct 31. Epub 2017 Oct 31.
    Department of Medicine, University of Dundee, Dundee, Scotland, UK.
    There are very few reports on the epidemiology of chronic hypoparathyroidism. A population-based study was undertaken to describe the prevalence and incidence of hypoparathyroidism in Tayside, Scotland. Data on biochemistry, hospital admissions, prescribing and death records in Tayside Scotland from 1988 to 2015 were linked electronically. Read More

    Bone Status among Patients with Non-Surgical Hypoparathyroidism, Autosomal Dominant Hypocalcaemia and Pseudohypoparathyroidism: a Cohort Study.
    J Bone Miner Res 2017 Oct 31. Epub 2017 Oct 31.
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Aarhus, Denmark.
    Non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP) are both rare diseases, characterized by hypocalcemia. In Ns-HypoPT, PTH levels are low, whereas patients with PHP often have very high levels due to receptor-insensitivity to PTH (PTH-resistance). Accordingly, we hypothesized that indices of bone turnover and bone mineralization/architecture are similar in Ns-HypoPT and PHP despite marked differences in PTH levels. Read More

    Peculiarities of autoimmune polyglandular syndromes in children and adolescents.
    Acta Biomed 2017 Oct 23;88(3):271-275. Epub 2017 Oct 23.
    Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
    Background: no reviews have specifically addressed , to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric ageObjectives: to review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescenceDesign: the main features of the different APSs in pediatric age were compared among them.

    Conclusions: 1) Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparathyroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications. Read More

    [Update on recent progress in vitamin D research. Vitamin D treatment for hypoparathyroidism.]
    Clin Calcium 2017 ;27(11):1623-1628
    Chiba Children's Hospital, Japan.
    The patients with hypoparathyroidism have been treated with active vitamin D(ie, alfacalcidol and calcitriol). Parathyroid hormone(PTH)increases extracellular calcium concentration partly through the activation of vitamin D, and active vitamin D corrects hypocalcemia mainly by increasing intestinal calcium abosorption. PTH coordinately increases blood calcium level with vitamin D in bone and kidney, however, renal tubular reabsorption of calcium is regulated by PTH-dependent mechanism. Read More

    HDR syndrome with a novel mutation in GATA3 mimicking a congenital X-linked stapes gusher: a case report.
    BMC Med Genet 2017 Oct 26;18(1):121. Epub 2017 Oct 26.
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
    Background: Hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome, also known as Barakat syndrome, is a rare genetic disorder with high phenotypic heterogeneity caused by haploinsufficiency of the GATA3 gene on chromosome 10p14-p15. For these reasons, the diagnosis of HDR syndrome is challenging and requires a high index of suspicion as well as genetic analysis.

    Case Presentation: A 14-month-old boy, with sensorineural hearing loss in both ears, showed typical radiological features of X-linked stapes gusher on preoperative temporal bone computed tomography (CT) for cochlear implantations. Read More

    Previously unreported abnormalities in Wolfram Syndrome Type 2.
    Pediatr Endocrinol Diabetes Metab 2017 ;23(2):107-110
    Ph.D. candidate. Department of Molecular Biology. Centre INRS-Institut Armand-Frappier, Laval, Quebec, Canada.
    Wolfram syndrome (WFS) is a rare autosomal recessive disease with non-autoimmune childhood onset insulin dependent diabetes and optic atrophy. WFS type 2 (WFS2) differs from WFS type 1 (WFS1) with upper intestinal ulcers, bleeding tendency and the lack ofdiabetes insipidus. Li-fespan is short due to related comorbidities. Read More

    Prolonged Duration of Surgery Predicts Postoperative Hypoparathyroidism among Patients Undergoing Total Thyroidectomy in a Tertiary Referral Centre.
    Eur Thyroid J 2017 Sep 24;6(5):255-262. Epub 2017 Apr 24.
    Department of Otorhinolaryngology Surgery, Rigshospitalet University Hospital, Copenhagen, Denmark.
    Background: Postoperative hypoparathyroidism is a common complication following total thyroidectomy. The aim of this study was to investigate the incidence of both transient and permanent hypoparathyroidism in patients undergoing total thyroidectomy in a tertiary referral centre and, furthermore, to identify early predictive risk factors.

    Methods: Based on a single-institution retrospective review, we identified 582 patients who underwent total thyroidectomy between January 2010 and March 2015. Read More

    The impact of different surgical procedures on hypoparathyroidism after thyroidectomy: A population-based study.
    Medicine (Baltimore) 2017 Oct;96(43):e8245
    aGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan bInternational Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan cDepartment of Dermatology, Wan Fang Hospital, Taipei, Taiwan dDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan eSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan fSchool of Health Care Administration, Taipei Medical University, Taipei, Taiwan gFaculty of Health Sciences, Macau University of Science and Technology, Macau, China hMaster Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan.
    The main objective of this study is to investigate the outcome between surgical procedures and the risk of development of hypoparathyroidism followed by surgical procedure in patients with thyroid disorders.We analyzed the data acquired from Taiwan's Bureau of National Health Insurance (BNHI) research database from 1998 to 2011 and found 9316 patients with thyroid surgery. Cox regression model was used to calculate the hazard ratio (HR). Read More

    TIME TO PARATHYROID FUNCTION RECOVERY IN PATIENTS WITH PROTRACTED HYPOPARATHYROIDISM AFTER TOTAL THYROIDECTOMY.
    Eur J Endocrinol 2017 Oct 24. Epub 2017 Oct 24.
    A Sitges-Serra, Departament de Cirurgia, Hospital del Mar, Barcelona, 08018, Spain
    Objective: Hypocalcemia is the most common adverse effect after total thyroidectomy. It recovers in about two thirds of the patients within the first postoperative month. Little is known, however, about recovery of the parathyroid function (RPF) after this time-period. Read More

    In situ preservation of the partathyroid glands in total thyroidectomy: a propensity score matched analysis.
    Ann Ital Chir 2017 ;88:288-294
    Aim: Severe hypocalcemia due to parathyroid gland damage may be a serious complication after thyroidectomy. In order to save parathyroid integrity we developed a no-touch parathyroid (NTP) thyroidectomy technique.

    Methods: We performed a total extracapsular thyroidectomy with NTP technique in consecutive 50 cases of benign goiter between July 2014 and June 2015. Read More

    [Association of vitamin D receptor gene polymorphisms with idiopathic hypoparathyroidism phenotypes].
    Zhonghua Yi Xue Za Zhi 2017 Sep;97(36):2833-2838
    Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Beijing 100730, China.
    Objective: To explore the association of vitamin D receptor (VDR) gene polymorphisms with idiopathic hypoparathyroidism (IHP). Methods: Two hundred and three patients with IHP and 209 healthy age- and sex-matched subjects were recruited at Peking Union Medical College Hospital between December 1987 and December 2015 as case group and control group, respectively. The VDR gene polymorphisms including rs739837, rs3847987 and rs2228570 were analyzed by Sequenom Mass Array. Read More

    Optimal dosing and delivery of PTH and its analogues for osteoporosis and hypoparathyroidism - translating the pharmacology.
    Br J Clin Pharmacol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
    In primary hyperparathyroidism (PHPT), bone loss results from the resorptive effects of excess parathyroid hormone (PTH). Under physiological conditions, PTH has actions that are more targeted to homeostasis and to bone accrual. The predominant action of PTH, either catabolic, anabolic, or homeostatic, can be understood in molecular and pharmacokinetic terms. Read More

    Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up.
    Clin Transplant 2017 Nov 16;31(11). Epub 2017 Oct 16.
    Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
    Background: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.

    Method: We performed PA from two donors to two recipients. Read More

    Impact of intercurrent illness on calcium homeostasis in children with hypoparathyroidism: a case series.
    Endocr Connect 2017 Nov;6(8):589-594
    Royal Manchester Children's HospitalManchester, UK
    Background: Hypoparathyroidism is characterised by hypocalcaemia, and standard management is with an active vitamin D analogue and adequate oral calcium intake (dietary and/or supplements). Little is described in the literature about the impact of intercurrent illnesses on calcium homeostasis in children with hypoparathyroidism.

    Methods: We describe three children with hypoparathyroidism in whom intercurrent illnesses led to hypocalcaemia and escalation of treatment with alfacalcidol (1-hydroxycholecalciferol) and calcium supplements. Read More

    Autoimmune endocrine diseases.
    Minerva Endocrinol 2017 Oct 9. Epub 2017 Oct 9.
    Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
    The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Read More

    How reliably can computed tomography predict thyroid invasion prior to laryngectomy?
    Laryngoscope 2017 Oct 8. Epub 2017 Oct 8.
    Department of Otorhinolaryngology Head and Neck Surgery, Aneurin Bevan University Health Board, The Royal Gwent Hospital, Newport, United Kingdom.
    Objectives/hypothesis: There is little evidence to support the removal of thyroid tissue during total laryngectomy. Although oncological control of the tumor is the priority, thyroidectomy can lead to hypothyroidism and hypoparathyroidism. This study aimed to test the usefulness of preoperative computed tomography in predicting histological invasion of the thyroid. Read More

    Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
    Am J Hum Genet 2017 Oct 28;101(4):616-622. Epub 2017 Sep 28.
    Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address:
    Inversion polymorphisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-allelic homologous recombination (NAHR) events and thus lead to genomic disorders. However, for the 22q11.2 deletion syndrome (22q11. Read More

    Evaluation of clinical significance and risk factors of incidental parathyroidectomy due to thyroidectomy: A single-center retrospective clinical study.
    Medicine (Baltimore) 2017 Sep;96(39):e8175
    Department of General Surgery, Beijing Chaoyang Hospital Affiliated Capital Medical University, Beijing, China.
    We assessed the clinical significance and risk factors of incidental parathyroidectomy during total thyroidectomy with or without central neck dissection or subtotal thyroidectomy.Retrospective analysis of clinical and pathological features of 548 consecutive thyroidectomy cases was compared by grouping into inadvertent resection (IR, n = 86) with IR of parathyroid glands, non-IR (n = 462) without, and then into postoperative hypoparathyroidism (PH, n = 140) with PH and non-PH (n = 408) without.Two hundred ninety-eight patients had total thyroidectomy and 250 had subtotal thyroidectomy. Read More

    Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection.
    Medicine (Baltimore) 2017 Sep;96(39):e8162
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    The risk factors of hypoparathyroidism after total thyroidectomy (TT) with central lymph node dissection (CND) have not been completely defined. The aim of the study was to evaluate the risk factors of hypoparathyroidism after the surgery.We retrospectively reviewed our patients who underwent TT and CND (including lateral lymph node dissection) for thyroid carcinoma between January 2013 and June 2016. Read More

    Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer.
    Nucl Med Commun 2017 Dec;38(12):1036-1040
    Departments of aNuclear Medicine bThyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
    Objective: Prophylactic central neck dissection (pCND) is controversial in papillary thyroid carcinoma (PTC) without clinical positive lymph nodes. The aim of this study was to investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in clinically node-negative (cN0) PTC patients treated with total thyroidectomy (TT) alone or in combination with pCND.

    Patients And Methods: One-hundred and sixty-seven cN0 PTC patients who underwent TT alone (TT) or in combination with pCND (TT+pCND) in our hospital from January 2014 to August 2015 were evaluated retrospectively. Read More

    Safety and Efficacy of Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism Randomly Assigned to Receive Fixed 25-μg or 50-μg Daily Doses.
    Clin Ther 2017 Oct 21;39(10):2096-2102. Epub 2017 Sep 21.
    Shire Human Genetic Therapies Inc, Lexington, Massachusetts.
    Purpose: The present study examined the efficacy and safety of a lower rhPTH(1-84) dose.

    Methods: RELAY was a dose-blinded, multicenter, 8-week study of patients with hypoparathyroidism randomized to fixed 25- or 50-μg/d doses of subcutaneous rhPTH(1-84). The primary end point was the percentage of patients at week 8 with supplement reductions in calcium to ≤500 mg/d and in calcitriol to ≤0. Read More

    Calcium and Bone Metabolism Indices.
    Adv Clin Chem 2017 7;82:1-46. Epub 2017 Aug 7.
    David Geffen School of Medicine, University of California, Los Angeles, CA, United States. Electronic address:
    Calcium and inorganic phosphate are of critical importance for many body functions, thus the regulations of their plasma concentrations are tightly controlled by the concerted actions of reabsorption/excretion in the kidney, absorption in the intestines, and exchange from bone, the major reservoir for calcium and phosphate in the body. Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D) control calcium homeostasis, whereas PTH, 1,25(OH)2D, and bone-derived fibroblast growth factor 23 (FGF 23) control phosphate homeostasis. Hypoparathyroidism can cause hypocalcemia and hyperphosphatemia, whereas deficient vitamin D actions can cause osteomalacia in adults and rickets in children. Read More

    Autosomal Dominant PTH Gene Signal Sequence Mutation in a Family With Familial Isolated Hypoparathyroidism.
    J Clin Endocrinol Metab 2017 Nov;102(11):3961-3969
    Regional Reference Centre for Medical Genetics, "Santa Maria della Misericordia" Hospital, Perugia 06129, Italy.
    Context: Familial isolated hypoparathyroidism (FIH) is a genetically heterogeneous disorder due to mutations of the calcium-sensing receptor (CASR), glial cells missing-2 (GCM2), guanine nucleotide binding protein α11 (GNA11), or parathyroid hormone (PTH) genes. Thus far, only four cases with homozygous and two cases with heterozygous mutations in the PTH gene have been reported.

    Objective: To clinically describe an FIH family and identify and characterize the causal gene mutation. Read More

    Recombinant Parathyroid Hormone Versus Usual Care: Do the Outcomes Justify the Cost?
    World J Surg 2017 Sep 19. Epub 2017 Sep 19.
    Department of Surgery, Section of Endocrine Surgery, University of California, San Francisco, 1600 Divisadero Street, Box 1674, San Francisco, CA, 94143, USA.
    Background: Hypoparathyroidism is a potential outcome of anterior neck surgery. Commonly it is managed by calcium and vitamin D supplementation in large doses, with attendant side effects. A recombinant human parathyroid hormone (rhPTH) is now available in the USA, offering a potentially more effective treatment. Read More

    Continuous Subcutaneous Recombinant Parathyroid Hormone (1-34) Infusion in the Management of Childhood Hypoparathyroidism Associated with Malabsorption.
    Horm Res Paediatr 2017 Sep 19. Epub 2017 Sep 19.
    Department of Pediatric Endocrinology, Bicêtre Hospital, Paris, France.
    Background/aims: Hypoparathyroidism associated with malabsorption can be particularly challenging to manage due to limited and erratic intestinal absorption of calcium and vitamin D analogues, resulting in episodes of hypo- or hypercalcaemia. We evaluated the role of continuous subcutaneous recombinant parathyroid hormone (rhPTH 1-34) infusion (CSPI) in children with hypoparathyroidism associated with intestinal malabsorption resistant to conventional therapy.

    Method: Four patients (8-13 years of age), with symptomatic hypocalcaemia resistant to conventional therapy, were started on CSPI (follow-up 3-8 years) in two paediatric endocrinology units in Europe. Read More

    Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors.
    Lab Invest 2017 Sep 18. Epub 2017 Sep 18.
    Department of Biomedical Sciences for Health, Endocrinology Service, Laboratory of Experimental Endocrinology, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
    Transcription factors active in embryonic parathyroid cells can be maintained in adult parathyroids and be involved in tumorigenesis. TBX1, the candidate gene of 22q11.2-DiGeorge syndrome, which includes congenital hypoparathyroidism, is involved in parathyroid embryogenesis. Read More

    Expanding the Phenotypic and Genotypic Landscape of Autoimmune Polyendocrine Syndrome Type 1.
    J Clin Endocrinol Metab 2017 Sep;102(9):3546-3556
    Department of Clinical Science, University of Bergen, Bergen 5020, Norway.
    Context: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene and characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency. Comprehensive characterizations of large patient cohorts are rare.

    Objective: To perform an extensive clinical, immunological, and genetic characterization of a large nationwide Russian APS-1 cohort. Read More

    Primary hyperparathyroidism: Dynamic postoperative metabolic changes.
    Clin Endocrinol (Oxf) 2017 Sep 14. Epub 2017 Sep 14.
    Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
    Objective: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated.

    Design: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intra-operatively, at postoperative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6. Read More

    Repurposing a novel parathyroid hormone (PTH) analog to treat hypoparathyroidism.
    Br J Pharmacol 2017 Sep 12. Epub 2017 Sep 12.
    Musculoskeletal Research, Lilly Research Laboratories, Eli Lilly & Co.
    Background And Purpose: Human parathyroid hormone (PTH) is critical for maintaining physiologic calcium homeostasis, and plays an important role in the formation and maintenance of bone. Full-length PTH and a truncated peptide form are approved for treatment of hypoparathyroidism and osteoporosis, respectively. Our initial goal was to develop an improved PTH therapy for osteoporosis, but clinical development was halted. Read More

    Serum Thyroid Hormone Antibodies Are Frequent in Patients with Polyglandular Autoimmune Syndrome Type 3, Particularly in Those Who Require Thyroxine Treatment.
    Front Endocrinol (Lausanne) 2017 28;8:212. Epub 2017 Aug 28.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison's disease and hypoparathyroidism. We evaluated the prevalence and repertoire of thyroid hormones antibodies (THAb) in PAS-3 patients. Using a radioimmunoprecipation technique, we measured THAb (T3IgM, T3IgG, T4IgM, and T4IgG) in 107 PAS-3 patients and 88 controls (patients with AITD without any NTAID). Read More

    Robot-Assisted Transaxillary Thyroidectomy (RATT): A Series Appraisal of More than 250 Cases from Europe.
    World J Surg 2017 Sep 8. Epub 2017 Sep 8.
    Department of Surgical Pathology, Medical, Molecular and Critical Area, University of Pisa, Via Paradisa 2, Pisa, Italy.
    Background: Robot-assisted transaxillary thyroidectomy (RATT) is widely accepted in Asian countries. However, concerns regarding the balance between its real advantages and safety and cost have been raised by North American authorities. In Europe, assessments have been limited by small numbers since now. Read More

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