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    A new mutation site in the AIRE gene causes autoimmune polyendocrine syndrome type 1.
    Immunogenetics 2017 May 24. Epub 2017 May 24.
    Department of Endocrinology, China Three Gorges University & Yichang Central People's Hospital, Yi Ling Road 181, Yichang, 443003, China.
    Autoimmune polyendocrine syndrome type 1 (APS-1, OMIM 2403000) is a rare autosomal recessive disease that is caused by autoimmune regulator (AIRE). The main symptoms of APS-1 are chronic mucocutaneous candidiasis, autoimmune adrenocortical insufficiency (Addison's disease) and hypoparathyroidism. We collected APS-1 cases and analysed them. Read More

    Analysis of factors affecting the development of hypocalcaemia after multinodular goitre surgery.
    Pol Przegl Chir 2017 Apr;89(2):26-30
    3 University Reaserch Hospital named after professor Kornel Gibiński of the Medical Univeristy of Silesia in Katowice, Ward of Alimentary Canal Surgery, Ward supervisor prof. Paweł lampe.
    Introduction: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. Read More

    Safety and Cost-Effectiveness in Thyroidectomy Using the HARMONIC Scalpel Compared to Traditional Hemostasis: A Controlled Clinical Assay.
    Surg Technol Int 2017 May 24;30. Epub 2017 May 24.
    General Surgery Department, Neck Surgery Clinic Hospital General de México OD, México D.F., México.
    Introduction: The aim of this clinical control trial is to analyze the cost-effectiveness and to understand the efficacy of the HARMONIC FOCUS®+ (Ethicon Inc., Somerville, New Jersey) scalpel as the only system to cut and coagulate in thyroidectomy.

    Materials And Methods: One hundered patients of the thyroid clinic of the Mexico City General Hospital were included. Read More

    A Novel De novo GATA-binding Protein 3 Mutation in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome.
    Chin Med J (Engl) 2017 Jun;130(11):1378-1380
    Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

    Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases.
    J Hum Genet 2017 May 18. Epub 2017 May 18.
    Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan.
    Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder of mitochondrial fatty-acid oxidation. Isolated long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is often reported in Caucasian countries due to a common mutation. However, the molecular and clinical basis of complete TFP deficiency has not been extensively reported. Read More

    Treatment of severe hypocalcaemia due to osteoblastic metastases in a patient with post-thyroidectomy hypoparathyroidism with (153)Sm-EDTMP.
    BMJ Case Rep 2017 May 16;2017. Epub 2017 May 16.
    National and Kapodistrian University of Athens - Faculty of Medicine, , Athens, Greece.
    Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with (153)Sm. Read More

    Timing and extension of lymphadenectomy in medullary thyroid carcinoma: A case series from a single institution.
    Int J Surg 2017 May;41 Suppl 1:S70-S74
    University of Perugia, Medical School, Endocrine Surgery Unit, S. Maria University Hospital, Terni, Italy. Electronic address:
    Background: Medullary thyroid carcinoma is an aggressive tumor and presents with significant morbidity and mortality and a high rate of lymph node metastases. The combination of total thyroidectomy and cervical lymphadenectomy is the essential treatment for those patients presenting with cervical lymph node metastases.

    Materials And Methods: A retrospective analysis of 117 patients operated for medullary thyroid carcinoma over a period of 15 years at a single institution. Read More

    Concurrent endocrine and other surgical procedures: an institutional experience.
    J Surg Res 2017 May 22;211:107-113. Epub 2016 Dec 22.
    Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin Milwaukee, WI. Electronic address:
    Inroduction: The number of endocrine procedures, specifically parathyroidectomy, thyroidectomy, and adrenalectomy, being performed is increasing. There is a paucity of literature on the feasibility of combining these procedures with other surgical procedures. Therefore, the aim of this study was to determine the effect of performing concurrent surgical procedures on postoperative outcomes. Read More

    Superior parathyroid gland approach to the recurrent laryngeal nerve.
    Head Neck 2017 May 11. Epub 2017 May 11.
    Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: The superior parathyroid gland is known to be almost constant in its location under the false thyroid capsule. Could it be a landmark to point to the site of incision of the false thyroid capsule and find the plane of the recurrent laryngeal nerve (RLN) during thyroidectomy?

    Methods: The study included 48 patients with benign goiter scheduled for hemithyroidectomy or total thyroidectomy; there were 16 cases of solitary thyroid nodules, 27 cases of multinodular goiter, and 5 cases of toxic goiter.

    Results: This study included 80 lobectomies. Read More

    Screening for Thyroid Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
    JAMA 2017 May;317(18):1888-1903
    Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Research Affiliates Evidence-based Practice Center, Seattle, Washington.
    Importance: The incidence of detected thyroid cancer cases has been increasing in the United States since 1975. The majority of thyroid cancers are differentiated cancers with excellent prognosis and long-term survival.

    Objective: To systematically review the benefits and harms associated with thyroid cancer screening and treatment of early thyroid cancer in asymptomatic adults to inform the US Preventive Services Task Force. Read More

    Epidemiology, management and outcomes of Graves' disease-real life data.
    Endocrine 2017 Jun 6;56(3):568-578. Epub 2017 May 6.
    Endocrine Surgery Unit, Directorate of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Purpose: Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surgery in Graves' disease. Read More

    Robotic thyroidectomy and parathyroidectomy: An initial experience with retroauricular approach.
    Head Neck 2017 May 5. Epub 2017 May 5.
    Division of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana.
    Background: New approaches for robotic-assisted thyroidectomy were recently described. The purpose of this study was to present the report of our initial experience using a retroauricular approach for thyroid and parathyroid surgeries.

    Methods: This is a prospective study that was conducted under institutional review board approval and all surgeries were performed by a single surgeon at a North American academic institution. Read More

    Population-Based Assessment of Complications following Surgery for Thyroid Cancer.
    J Clin Endocrinol Metab 2017 Apr 28. Epub 2017 Apr 28.
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
    Context: As thyroid cancer incidence rises, more patients undergo thyroid surgery. Although post-operative complication rates have been reported in single institution studies, population-based data is limited.

    Objective: Determine thyroid cancer surgery complication rates and identify at-risk populations. Read More

    Childhood Polyarthritis As Early Manifestation of Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy Syndrome.
    Front Immunol 2017 18;8:377. Epub 2017 Apr 18.
    Division of Pediatric Rheumatology, Penn State Children's Hospital, Hershey, PA, USA.
    Autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) is a rare disorder of immune dysregulation caused by mutations in the autoimmune regulator (AIRE) gene. Individuals affected with APECED develop a clinical syndrome characterized by ectodermal abnormalities, autoantibody production, and organ-specific autoimmune manifestations. Inflammatory arthritis is usually not described as a part of the syndrome, and only sporadic cases are reported. Read More

    Optimal extent of prophylactic central neck dissection for papillary thyroid carcinoma: Comparison of unilateral versus bilateral central neck dissection.
    Asian J Surg 2017 Apr 25. Epub 2017 Apr 25.
    Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Republic of Korea. Electronic address:
    Objective: The aim of the study was to determine the optimal extent of prophylactic central neck dissection (pCND) in papillary thyroid carcinoma (PTC).

    Materials And Methods: We studied 384 patients with clinically node-negative unilateral PTC who had undergone total thyroidectomy with pCND. Of these, 169 patients underwent unilateral pCND, and 215, bilateral pCND. Read More

    [Fahr syndrome secondary to primary hypoparathyroidism: about a case].
    Pan Afr Med J 2017 4;26. Epub 2017 Jan 4.
    Service de Biochimie-Toxicologie, Hôpital Militaire Moulay Ismail Meknès, Maroc.
    Fahr syndrome is a rare anatomo-clinic disease whose most common cause is primary or postoperative hypoparathyroidism. It is characterized by bilateral and symmetrical intracerebral calcifications located in the central gray nuclei, most often associated with phosphocalcium metabolism disorders. We here report the case of a 54-year old patient who had been treated for primary hypoparathyroidism for 20 years, presenting with amnesic disorders revealing Fahr syndrome secondary to hypoparathyroidism. Read More

    Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study.
    Endocr Connect 2017 Apr 26. Epub 2017 Apr 26.
    E Bhatia, Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Objective: Autoimmune polyendocrine syndrome type 1 (APS 1) is a rare autosomal recessive disorder characterized by progressive organ-specific autoimmunity. There is scant information on APS1 in ethnic groups other than European Caucasians. We studied clinical aspects and autoimmune regulator (AIRE) gene mutations in a cohort of Indian APS1 patients. Read More

    Endocrine Complications of Surgical Treatment of Thyroid Cancer: An Update.
    Exp Clin Endocrinol Diabetes 2017 Apr 25. Epub 2017 Apr 25.
    Department of Endocrinology. Hospital Ramón y Cajal, Madrid (Spain).
    Postoperative hypoparathyroidism (HypoPT) and hypothyroidism (HypoT) are the main endocrine complications after the surgical treatment for thyroid cancer. Postsurgical HypoPT can be transient, protracted or permanent. Its frequency varies according to the underlying cervical pathology, surgical technique, and mainly the experience of the surgeon. Read More

    A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism.
    Hum Genet 2017 Apr 25. Epub 2017 Apr 25.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Isolated familial hypoparathyroidism is an extremely rare disorder, which to date has been linked to several loci including mutations in CASR, GCM2, and PTH, as well as a rare condition defined as X-linked recessive hypoparathyroidism, previously associated with a 1.5 Mb region on Xq26-q27. Here, we report a patient with hypocalcemia-induced seizures leading to the diagnosis of primary hypoparathyroidism. Read More

    Risk factors for postoperative hypocalcemia.
    Updates Surg 2017 Apr 25. Epub 2017 Apr 25.
    Department of General Surgery, General and Obesity Surgical Unit, Second University of Naples, Naples, Italy.
    Hypocalcaemia is one of the most common complications after thyroidectomy; however, it is still unclear what preoperative factors could predict this event. The aim of this study was to evaluate the role of risk factors for hypocalcaemia after total thyroidectomy (TT). Consecutive patients who underwent total thyroidectomyat our institution between January 2014 and January 2016 were enrolled. Read More

    [Central compartment reoperation for recurrent/persistent differentiated thyroid cancer].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Apr;52(4):263-266
    Department of Head and Neck Surgery, Cancer Hospital(Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
    Objective: To analyze the incidences of complications after central compartment reoperation for recurrent/persistent differentiated thyroid cancer, and to investigate the safety and feasiblity of central compartment reoperation. Methord: A total of 109 patients who underwent central compartment reoperation for recurrent/persistent differentiated thyroid cancer from January 1, 2011 to March 31, 2016 in Cancer Hospital, Chinese Academy of Medical Sciences was analysed retrospectively, and the incidences of reoperation-related complications were evaluated. Results: Among 109 patients, only 10 (9. Read More

    Other organ involvement and clinical aspects of Wilson disease.
    Handb Clin Neurol 2017 ;142:157-169
    Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland. Electronic address:
    Wilson disease (WD) is a rare disorder of copper metabolism that presents mainly with hepatic and neuropsychiatric features. Copper accumulates not only in the liver and brain, but also in other organs. Liver injury can also be the cause of secondary impairment of other tissues. Read More

    Idiopathic hypoparathyroidism with extensive intracranial calcification in children: First report from Saudi Arabia.
    Medicine (Baltimore) 2017 Apr;96(16):e6347
    aPediatric Hepatologist, Faculty of Medicine, Cairo University, Cairo, Egypt. Pediatric Hepatologist, Alhada Armed Forces Hospital, Taif, KSA bPediatric endocrinologist, Armed Forces Hospitals of Taif Region, Taif, KSA cPediatric neonatologist, Alhada Armed Forces Hospital, Taif, KSA dPediatric endocrinologist, Alhada Armed Forces Hospital, Taif, KSA ePediatrics, Children Hospital, Taif, KSA fPediatric Allergist and immunologist Alhada Armed Forces Hospital, Taif, KSA gPediatric Nephrologist, College of Medicine, Taif University, Taif, KSA hMedical intern, Taif University, Taif, KSA iPediatric Hematologist and Oncologist, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Rationale: Pediatric idiopathic hypoparathyroidism with extensive intracranial calcifications outside the basal ganglia (BG) is extremely rare with less than 10 cases worldwide.

    Patient Concerns: An 11-year-old Saudi male child presented with tetany with otherwise normal neurological and other body system examination diagnoses severe hypocalcemia for differential diagnosis.

    Interventions: Further investigations revealed hyperphosphatemia and undetectable serum intact parathyroid hormone. Read More

    Growth characteristics and endocrine abnormalities in 22q11.2 deletion syndrome.
    Am J Med Genet A 2017 May 16;173(5):1301-1308. Epub 2017 Feb 16.
    Pediatric Endocrinology and Diabetes Unit, The Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
    22q11.2 deletion syndrome (22q11.2DS) has a wide range of clinical features including endocrine abnormalities. Read More

    Role of prophylactic central neck dissection in clinically node-negative differentiated thyroid cancer: assessment of the risk of regional recurrence.
    Updates Surg 2017 Apr 13. Epub 2017 Apr 13.
    Division of General Surgery and Surgical Oncology, School of Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy.
    Prophylactic central neck dissection in clinically node-negative patients remains controversial. The aim of this multicenter retrospective study was to determine the rate of metastases in the central neck in clinically node-negative differentiated thyroid cancer patients, to examine the morbidity, and to assess the risk of regional recurrence in patients treated with total thyroidectomy with concomitant bilateral or ipsilateral central neck dissection compared with those undergoing total thyroidectomy alone. 258 consecutive clinically node-negative patients were divided into three groups according to the procedures performed: total thyroidectomy only (group A), total thyroidectomy with concomitant ipsilateral central neck dissection (group B), and total thyroidectomy combined with bilateral central neck dissection (group C). Read More

    No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis?
    PLoS One 2017 13;12(4):e0174797. Epub 2017 Apr 13.
    Developmental Imaging and Psychopathology Lab, Department of Psychiatry, School of Medicine, University of Geneva, Geneva, Switzerland.
    Background: The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Read More

    Basal Ganglia Calcification with Tetanic Seizure Suggest Mitochondrial Disorder.
    Am J Case Rep 2017 Apr 9;18:375-380. Epub 2017 Apr 9.
    Department of Radiology, Krankenanstalt Rudolfstiftung, Vienna, Austria.
    BACKGROUND Basal ganglia calcification (BGC) is a rare sporadic or hereditary central nervous system (CNS) abnormality, characterized by symmetric or asymmetric calcification of the basal ganglia. CASE REPORT We report the case of a 65-year-old Gypsy female who was admitted for a tetanic seizure, and who had a history of polyneuropathy, restless-leg syndrome, retinopathy, diabetes, hyperlipidemia, osteoporosis with consecutive hyperkyphosis, cervicalgia, lumbalgia, struma nodosa requiring thyroidectomy and consecutive hypothyroidism, adipositas, resection of a vocal chord polyp, arterial hypertension, coronary heart disease, atheromatosis of the aorta, peripheral artery disease, chronic obstructive pulmonary disease, steatosis hepatis, mild renal insufficiency, long-term hypocalcemia, hyperphosphatemia, impingement syndrome, spondylarthrosis of the lumbar spine, and hysterectomy. History and clinical presentation suggested a mitochondrial defect which also manifested as hypoparathyroidism or Fanconi syndrome resulting in BGC. Read More

    Association of airway abnormalities with 22q11.2 deletion syndrome.
    Int J Pediatr Otorhinolaryngol 2017 May 21;96:11-14. Epub 2017 Feb 21.
    22q and You and Clinical Genetics Centers, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
    Introduction: 22q11.2 deletion syndrome (22q11.2DS) presents with complex but variable symptoms, including cardiac, immune, palatal, endocrine, cognitive, and psychiatric issues. Read More

    Delayed Post-Surgical Hypoparathyroidism: The Forgotten Chameleon!
    J Clin Diagn Res 2017 Feb 1;11(2):OD07-OD09. Epub 2017 Feb 1.
    Senior Specialist and Head of Department, Department of Medicine, Tata Main Hospital , Jamshedpur, Jharkhand, India .
    Delayed hypoparathyroidism, due to accidental gland removal or ischemia of parathyroids can present many years after thyroidectomy and symptoms may be non-specific. This condition, if not diagnosed timely, may prove fatal and have serious consequences. Hence, clinicians must have a high index of suspicion to treat this condition. Read More

    Iatrogenic Calcinosis Cutis Successfully Treated with Topical Sodium Thiosulfate.
    Pediatr Dermatol 2017 May 6;34(3):356-358. Epub 2017 Apr 6.
    Department of Pediatrics, Hospital Universitario Virgen del Rocío, Seville, Spain.
    Calcinosis cutis is a term used to describe a group of disorders in which calcium salt deposits form in the skin and subcutaneous tissue. We report a 6-year-old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia being treated with calcium gluconate intravenous infusion through peripheral veins. Within a few days we made a diagnosis of iatrogenic calcinosis cutis and treatment with 10% topical sodium thiosulfate was prescribed; complete resolution of lesions was achieved after 6 months, with no local or systemic adverse effects. Read More

    An Adult Case of Chromosome 22q11.2 Deletion Syndrome Associated with a High-positioned Right Aortic Arch.
    Intern Med 2017 1;56(7):865-872. Epub 2017 Apr 1.
    Department of Internal Medicine, Keiaido Hospital, Japan.
    Chromosome 22q11.2 deletion syndrome (22q11.2 DS) has a very wide phenotypic spectrum that includes dysmorphic features, cardiac anomalies, and hypocalcemia arising from hypoparathyroidism. Read More

    Staged Surgery for Advanced Thyroid Cancers: Safety and Oncologic Outcomes of Neural Monitored Surgery.
    Otolaryngol Head Neck Surg 2017 May 4;156(5):816-821. Epub 2017 Apr 4.
    1 Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary & Harvard Medical School, Boston, Massachusetts, USA.
    Objective Thyroidectomy with extensive multicompartment bilateral neck dissections for advanced-stage thyroid cancer may lead to increased risk of complications, including bilateral recurrent laryngeal nerve (RLN) paralysis and hypoparathyroidism. A planned staged approach derived from a detailed preoperative radiographic map is associated with a low complication profile. This study evaluates oncologic results and safety of neural monitored, staged thyroid cancer surgery for management of advanced thyroid cancer. Read More

    Parathyroid hormone controls paracellular Ca(2+) transport in the thick ascending limb by regulating the tight-junction protein Claudin14.
    Proc Natl Acad Sci U S A 2017 Apr 3;114(16):E3344-E3353. Epub 2017 Apr 3.
    Division of Bone and Mineral Research, Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115;
    Renal Ca(2+) reabsorption is essential for maintaining systemic Ca(2+) homeostasis and is tightly regulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling pathway. We investigated the role of PTH1R in the kidney by generating a mouse model with targeted deletion of PTH1R in the thick ascending limb of Henle (TAL) and in distal convoluted tubules (DCTs): Ksp-cre;Pth1r(fl/fl) Mutant mice exhibited hypercalciuria and had lower serum calcium and markedly increased serum PTH levels. Unexpectedly, proteins involved in transcellular Ca(2+) reabsorption in DCTs were not decreased. Read More

    Acute symptomatic hypocalcemia from immune checkpoint therapy-induced hypoparathyroidism.
    Am J Emerg Med 2017 Feb 27. Epub 2017 Feb 27.
    Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:
    Background: Ipilimumab (a monoclonal antibody against CTLA-4) and nivolumab (a humanized antibody against PD-1) target these immune checkpoint pathways and are used for treatment of melanoma and an increasing number of other cancers. However, they may cause immune-related adverse effects (IRAEs). Although many endocrinopathies are known to be IRAEs, primary hypoparathyroidism with severe hypocalcemia has never been reported. Read More

    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation.
    J Vis Exp 2017 Mar 14(121). Epub 2017 Mar 14.
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School;
    Hypoparathyroidism (HP) is a disorder characterized by low levels of PTH which lead to hypocalcemia, hyperphosphatemia, and low bone turnover. The most common cause of the disease is accidental removal of the parathyroid glands during thyroid surgery. Novel therapies for HP are needed, but testing them requires reliable animal models of acquired HP. Read More

    Surgery for Neck Recurrence of Differentiated Thyroid Cancer: Outcomes and Risk Factors.
    J Clin Endocrinol Metab 2017 Mar;102(3):1020-1031
    Department of Nuclear Medicine and Endocrine Oncology and.
    Background: Persistent/recurrent disease in the neck is frequent in patients with differentiated thyroid cancer (DTC).

    Objective: Assess efficacy, safety, and prognostic factors of first neck reoperation in DTC.

    Methods: Retrospective study of consecutive patients undergoing neck reoperation for recurrent/persistent DTC in a referral cancer center. Read More

    Association of Parathyroid Gland Biopsy Excision Technique With Ex Vivo Radiation Counts During Radioguided Parathyroid Surgery.
    JAMA Otolaryngol Head Neck Surg 2017 Mar 30. Epub 2017 Mar 30.
    Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock.
    Importance: Parathyroid biopsy represents a means for normal and hyperfunctional glands to be distinguished intraoperatively. However, no data exist to guide surgeons regarding how much of a parathyroid gland must be biopsied to satisfy the 20% rule.

    Objective: To quantify the relative proportion of a hyperfunctional parathyroid gland that must be evaluated with the gamma probe to satisfy the 20% rule. Read More

    Parathyroid score can predict the duration of required calcium supplementation after total thyroidectomy.
    PLoS One 2017 28;12(3):e0174088. Epub 2017 Mar 28.
    Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Background: Postoperative hypoparathyroidism is the most common complication after total thyroidectomy, owing to unintentional injury or decreased blood flow to the parathyroid glands. Prediction of postoperative hypoparathyroidism would be helpful for surgeons to manage postoperative hypocalcemia. In this study, we scored the discoloration of the parathyroid glands using a new parathyroid scoring system and evaluated the correlation between the parathyroid score and duration of required calcium supplementation after total thyroidectomy. Read More

    Robotic thyroidectomy versus conventional open thyroidectomy for thyroid cancer: a systematic review and meta-analysis.
    Surg Endosc 2017 Mar 23. Epub 2017 Mar 23.
    Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
    Background: Despite the new technical alternative offered by the robotic surgery for minimally invasive thyroid surgery, the role of the robotic thyroidectomy (RT) in thyroid cancer has been highly disputed. This paper gives a systematic review and meta-analysis aiming to compare RT and open thyroidectomy (OT) based on the surgical outcomes and oncologic results.

    Methods: Relevant literature was searched from various databases up to July 2016, including PubMed, MEDLINE, EMBASE, Cochrane Library, Web of science and Clinical Trials. Read More

    Drug safety evaluation of parathyroid hormone for hypocalcemia in patients with hypoparathyroidism.
    Expert Opin Drug Saf 2017 May 3;16(5):617-625. Epub 2017 Apr 3.
    a Bone Metabolic Diseases Unit, Department of Surgery and Translational Medicine , University of Florence , Florence , Italy.
    Introduction: Hypoparathyroidism is a rare disorder characterized by low serum calcium levels and high serum phosphate levels, and low or inappropriately normal levels of parathyroid hormone (PTH). This disease is commonly treated with calcium supplements and active vitamin D metabolites or analogues, but large doses of these supplements are often utilized to relieve the symptoms caused by hypocalcemia, without guarantee of a physiological normalization of calcium-phosphate homeostasis. Areas covered: Several studies have investigated replacement therapy with recombinant human PTH [rhPTH (1-84) and rhPTH (1-34)] for subjects with hypoparathyroidism. Read More

    A case of autoimmune polyendocrine syndrome type I with strong positive GAD antibody titer, followed up with glucose tolerance measured by oral glucose tolerance test.
    Neuro Endocrinol Lett 2017 Jan;37(8):540-542
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
    A 26-year-old Japanese woman presented with adrenal insufficiency, and treatment was started with cortisone and fludrocortisone in 1975. A few years later, she presented with hypoparathyroidism and was diagnosed with autoimmune polyendocrine syndrome type I (APS I), and treatment with calcium and alfacalcidol was started. She was found to have subacute thyroiditis and relative adrenal failure in 2006. Read More

    Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol.
    J Clin Endocrinol Metab 2017 May;102(5):1505-1510
    Department of Endocrinology, Diabetes and Nutrition, University of Maryland Medical Center, Baltimore, Maryland 21201.
    Context: Options for chronic treatment of hypoparathyroidism include calcitriol, recombinant human parathyroid hormone, and high-dose vitamin D (D2). D2 is used in a minority of patients because of fear of prolonged hypercalcemia and renal toxicity. There is a paucity of recent data about D2 use in hypoparathyroidism. Read More

    Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
    J Clin Endocrinol Metab 2017 May;102(5):1726-1733
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
    Context: Most cases of autosomal recessive hypoparathyroidism (HYPO) are caused by loss-of-function mutations in GCM2 or PTH.

    Objective: The objective of this study was to identify the underlying genetic basis for isolated HYPO in a kindred in which 3 of 10 siblings were affected.

    Subjects: We studied the parents and the three adult affected subjects, each of whom was diagnosed with HYPO in the first decade of life. Read More

    Clinical Auditory Phenotypes Associated with GATA3 Gene Mutations in Familial Hypoparathyroidism-deafness-renal Dysplasia Syndrome.
    Chin Med J (Engl) 2017 Mar;130(6):703-709
    Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    Background: Hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome is an autosomal dominant disorder primarily caused by haploinsufficiency of GATA binding protein 3 (GATA3) gene mutations, and hearing loss is the most frequent phenotypic feature. This study aimed at identifying the causative gene mutation for a three-generation Chinese family with HDR syndrome and analyzing auditory phenotypes in all familial HDR syndrome cases.

    Methods: Three affected family members underwent otologic examinations, biochemistry tests, and other clinical evaluations. Read More

    The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study.
    Langenbecks Arch Surg 2017 Mar 15. Epub 2017 Mar 15.
    Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery, Policlinico "P. Giaccone", University of Palermo, Via L. Giuffré 5, 90100, Palermo, Italy.
    Purpose: Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors.

    Methods: A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Read More

    Unintentional parathyroidectomy during total thyroidectomy surgery: A single surgeon's experience.
    Medicine (Baltimore) 2017 Mar;96(11):e6411
    aDepartment of Head Neck, First Affiliated Hospital of Zhengzhou University bDepartment of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China.
    In this study, we investigated incidental parathyroidectomy during total thyroidectomy surgery that required central lymph node dissection and the potential risk factors. Patients requiring total thyroidectomy and tracheoesophageal groove node dissection were enrolled in the study from January 2013 to June 2015 and we obtained all medical information, including pathology reports. Furthermore, we recorded the parathyroid hormone level in all patients prior to operation and then 3 further times: 1 day, 1 week, and 3 months after surgery. Read More

    Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis.
    Onco Targets Ther 2017 27;10:1247-1260. Epub 2017 Feb 27.
    Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China.
    Purpose: To investigate whether carbon nanoparticles (CNs) are helpful in identifying lymph nodes and metastatic lymph nodes and in parathyroid protection during thyroid cancer surgery.

    Methods: English and Chinese literature in PubMed, Cochrane Database of Systematic Reviews, EMBASE,, China Biology Medicine Database, China National Knowledge Infrastructure, China Master's and Doctoral Theses Full-Text Database, Wanfang database, and Cqvip database were searched (till March 22, 2016). Read More

    Preoperative ultrasound-guided carbon nanoparticles localization for metastatic lymph nodes in papillary thyroid carcinoma during reoperation: A retrospective cohort study.
    Medicine (Baltimore) 2017 Mar;96(10):e6285
    aDepartment of Thyroid & Parathyroid Surgery bDepartment of Ultrasound, West China Hospital cWest China School of Stomotology, Sichuan University, Chengdu, PR China.
    Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective cohort study enrolled 52 patients who were diagnosed with lymph node metastasis by histopathology and underwent reoperation from October 2015 to February 2016. Read More

    Hypoparathyroidism after thyroidectomy: prevention, assessment and management.
    Curr Opin Otolaryngol Head Neck Surg 2017 Apr;25(2):142-146
    aDepartment of Head and Neck Surgery, Hospital das Clínicas, São Paulo School of Medicine, São Paulo. Chairman, Department of Head and Neck Surgery, Hospital Ana Costa, Santos and Irmandade da Santa Casa de Misericórdia, SantosbDepartment of Head and Neck Surgery, Hospital das Clínicas, São Paulo School of Medicine, São PaulocDepartment of Head and Neck Surgery, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil.; Institution: Department of Head and Neck Surgery, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil.
    Purpose Of Review: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy and it can cause significant morbidity and increased costs. Its incidence varies from 30% to 60%.

    Recent Findings: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism. Read More

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