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    1 OF 161

    Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study.
    Chin J Cancer Res 2017 Jun;29(3):223-230
    Department of Head and Neck Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.
    Objective: The American Thyroid Association (ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma (MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.

    Methods: A total of 73 patients from 22 families were screened as rearranged during transfection (RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Read More

    Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial.
    Int J Surg 2017 Jul 18;45:29-34. Epub 2017 Jul 18.
    Department of Surgery, Minia University Hospital, Egypt.
    Background: Due to high recurrence rate after subtotal thyroidectomy, most of centers have shifted to total thyroidectomy as a surgical treatment for benign multinodular goiter (BMNG), but serious complications, as laryngeal nerve affection & hypocalcaemia, are still present. This study aimed to evaluate treatment of BMNG using intra-capsular total thyroid enucleation in comparison to standard total thyroidectomy.

    Patients &methods: This is a prospective randomized controlled clinical trial conducted in a hospital in the period from December 2009 to December 2015. Read More

    Transoral endoscopic thyroidectomy vestibular approach (TOETVA): indications, techniques and results.
    Surg Endosc 2017 Jul 17. Epub 2017 Jul 17.
    Department of Otolaryngology Head Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.
    Introduction: The Transoral Neck Surgery (TONS) Study Group was established at the 1st International Thyroid NOTES Conference in February 2016 with the intention of standardizing and refining thyroid NOTES techniques, including both transoral endoscopic and robotic thyroidectomy approaches. Herein, the authors report the modification of indications, preparation, and step-by-step explanations for operative techniques, as well as results and postoperative care for transoral endoscopic thyroidectomy vestibular approach (TOETVA).

    Methods: Between February 2015 and December 2015, a total of 200 patients comprising 8 males (4%) and 192 females (96%) underwent TOETVA using 3 laparoscopic ports inserted at the oral vestibule. Read More

    Recent Developments for Introducing a Hexafluoroisopropanol Unit into the Vitamin D Side Chain.
    J Steroid Biochem Mol Biol 2017 Jul 14. Epub 2017 Jul 14.
    Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan; AMED-CREST, AMED, Japan. Electronic address:
    Among numerous studies on synthetic approaches to and the biological activities of vitamin D analogues, we herein focused on falecalcitriol, an analogue of calcitriol (1α,25-dihydroxyvitamin D3), in which a 26,26,26,27,27,27-hexafluoroisopropanol unit has been introduced into the side chain. Falecalcitriol was designed to escape from the metabolism of CYP24A1 and has been used as a drug to treat secondary hypoparathyroidism since 2001. Its metabolite, the 23-hydroxy form, retains biological activity and resistants to further metabolism. Read More

    Thyroid Surgery: To Drain or Not to Drain, That Is the Problem - A Randomized Clinical Trial.
    ORL J Otorhinolaryngol Relat Spec 2017 Jul 15;79(4):202-211. Epub 2017 Jul 15.
    Department of Surgery, University of L'Aquila, L'Aquila, Italy.
    Purpose: We conducted a prospective, randomized study to evaluate the necessity of drainage after thyroid surgery.

    Methods: The patients (n = 215) were randomly assigned to be treated with suction drains (group 1; n = 108) or not (group 2; n = 107).

    Results: The postoperative pain scores were significantly lower in the non-drained group than in the drained group of patients at postoperative days 0 and at 1. Read More

    [Risk factors' analysis of transient and permanent hypoparathyroidism after thyroidectomy].
    Clin Ter 2017 Jul-Aug;168(4):e271-e277
    Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone", Palermo - Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche, Università degli Studi di Palermo, Italia.
    Aims: This review evaluates those main risk factors that can affect patients undergoing thyroidectomy, to reach a better pre- and post-operative management of transient and permanent hypoparathyroidism.

    Discussion: The transient hypoparathyroidism is a potentially severe complication of thyroidectomy, including a wide range of signs and symptoms that persists for a few weeks. The definitive hypoparathyroidism occurs when a medical treatment is necessary over 12 months. Read More

    [Endocrinology, what's new in 2016].
    Rev Med Suisse 2017 Jan;13(544-545):45-48
    Service d'endocrinologie, diabétologie, nutrition et hypertension, Département des spécialités de médecine, HUG, 1211 Genève 14.
    The European Society of Endocrinology has published this year a series of guidelines for hypoparathyroidism, the management of adrenal incidentalomas as well as for the long-term follow-up of patients operated on for a phaeochromocytoma/paraganglioma (PPGL). For hypoparathyroidism, guidelines insist on screening for chronic complications and monitoring treatment with calcium and vitamin D; the use of recombinant PTH may provide new opportunities for the future. Concerning adrenal incidentalomas, the panel of the guidelines primarily recommends non contrast CT for the evaluation of the risk of malignancy. Read More

    Delayed diagnosis of 22q11 deletion syndrome due to late onset hypocalcemia in a 11-year-old girl with imperforated anus.
    Ann Pediatr Endocrinol Metab 2017 Jun 28;22(2):133-138. Epub 2017 Jun 28.
    Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Neonatal hypocalcemia and congenital heart defects has been known as the first clinical manifestation of the chromosome 22q11.2 deletion syndrome (22q11DS). However, because of its wide clinical spectrum, diagnosis of 22q11DS can be delayed in children without classic symptoms. Read More

    Peripheral Neuropathy, Episodic Rhabdomyolysis, and Hypoparathyroidism in a Patient with Mitochondrial Trifunctional Protein Deficiency.
    JIMD Rep 2017 Jul 7. Epub 2017 Jul 7.
    Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands.
    A combination of unexplained peripheral neuropathy, hypoparathyroidism, and the inability to cope with metabolic stress could point to a rare inborn error of metabolism, such as mitochondrial trifunctional protein (MTP) deficiency.Here, we describe a 20-year-old woman who was known since childhood with axonal motor sensory polyneuropathy of unknown origin. She presented with progressive dyspnoea, and increased muscle weakness, preceded by 6 days of fever, vomiting, and diarrhoea. Read More

    [Oral diseases in auto-immune polyendocrine syndrome type 1].
    Presse Med 2017 Jul 3. Epub 2017 Jul 3.
    Polyclinique Aguilera, 21, rue de l'Estagnas, 64200 Biarritz, France.
    Auto-immune polyendocrine syndrome type 1 (APS1) also called Auto-immune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare monogenic childhood-onset auto-immune disease. This autosomal recessive disorder is caused by mutations in the auto-immune regulator (AIRE) gene, and leads to autoimmunity targeting peripheral tissues. There is a wide variability in clinical phenotypes in patients with APSI, with auto-immune endocrine and non-endocrine disorders, and chronic mucocutaneous candidiasis. Read More

    A Prospective Study on Role of Supplemental Oral Calcium and Vitamin D in Prevention of Postthyroidectomy Hypocalcemia.
    Indian J Endocrinol Metab 2017 Jul-Aug;21(4):498-503
    Department of Endocrine Surgery, Madras Medical College, Chennai, Tamil Nadu, India.
    Background: Postoperative transient hypocalcemia is sequelae of total thyroidectomy (TT), which is observed in up to 50% of patients. Routine oral calcium and Vitamin D supplementation have been proposed to prevent symptomatic hypocalcemia preventing morbidity and facilitating early discharge.

    Patients And Methods: A total of 208 patients with nontoxic benign thyroid disorders, undergoing TT, were serially randomized into four groups: Group A (no supplements were given), Group B (oral calcium - 2 g/day given), Group C (calcium and calcitriol - 1 mcg/day are given), and Group D (calcium, calcitriol, and cholecalciferol - 60,000 IU/day are given). Read More

    Hypothyroidism associated with parathyroid disorders.
    Best Pract Res Clin Endocrinol Metab 2017 Mar 15;31(2):161-173. Epub 2017 Apr 15.
    Endocrinology Service, Department of Biomedical Sciences, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Electronic address:
    Hypothyroidism may occur in association with congenital parathyroid disorders determining parathyroid hormone insufficiency, which is characterized by hypocalcemia and concomitant inappropriately low secretion of parathormone (PTH). The association is often due to loss of function of genes common to thyroid and parathyroid glands embryonic development. Hypothyroidism associated with hypoparathyroidism is generally mild and not associated with goiter; moreover, it is usually part of a multisystemic involvement not restricted to endocrine function as occurs in patients with 22q11 microdeletion/DiGeorge syndrome, the most frequent disorders. Read More

    How to avoid and to manage post-operative complications in thyroid surgery.
    Updates Surg 2017 Jun 23;69(2):211-215. Epub 2017 Jun 23.
    Endocrinesurgery Unit, "Policlinico-Vittorio Emanuele" Hospital, University of Catania, Via Santa Sofia 78, Catania, Italy.
    Complications of thyroidectomy are hypoparathyroidism, recurrent laryngeal nerve palsy, and hemorrhage. These complications have a low incidence. Hypoparathyroidism is the most frequent complication of total thyroidectomy. Read More

    A Case of "Late" Postsurgical Hypoparathyroidism.
    Case Rep Endocrinol 2017 31;2017:3962951. Epub 2017 May 31.
    Department of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, SP, Brazil.
    Introduction: Postsurgical hypoparathyroidism normally occurs a short time after thyroid surgery in form of two clinical syndromes of different etiology and prognosis. The first is transitory and might spontaneously recover within a few weeks or months. The second is permanent and needs a definitive treatment. Read More

    To assess the effects of parathyroidectomy (TPTX versus TPTX+AT) for Secondary Hyperparathyroidism in chronic renal failure: A meta-analysis.
    Int J Surg 2017 Jun 17. Epub 2017 Jun 17.
    Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China.
    Background: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT. Read More

    [Algorithms based on medico-administrative data in the field of endocrine, nutritional and metabolic diseases, especially diabetes].
    Rev Epidemiol Sante Publique 2017 Jun 15. Epub 2017 Jun 15.
    Caisse nationale d'assurance maladie des travailleurs salariés, 75020 Paris, France.
    Background: Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field.

    Methods: Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described. Read More

    Incidence of parathyroid disorders in Indian adult male population: A 25-year follow-up study.
    Clin Endocrinol (Oxf) 2017 Jun 15. Epub 2017 Jun 15.
    Department Pediatrics, Army Hospital (Research and Referral), Delhi, India.
    Context And Objective: Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration. Read More

    Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients.
    J Visc Surg 2017 Jun 8. Epub 2017 Jun 8.
    Service de chirurgie digestive et viscérale, hôpital Trousseau, avenue de la République, 37170 Chambray-lès-Tours, France.
    Total thyroidectomy for substernal goiter occasionally requires a sternotomy associated with a cervical incision. We sought to analyze the postoperative complications of thyroidectomy for substernal goiters in our center and more precisely the complications related to the sternotomy. All patients who underwent total thyroidectomy for substernal goiter in our center between 2007 and 2016 were reviewed retrospectively. Read More

    Long-term outcomes of central neck dissection for cN0 papillary thyroid carcinoma.
    Am J Otolaryngol 2017 Jun 7. Epub 2017 Jun 7.
    Otolaryngology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy.
    Objective: The risk-benefit ratio of central neck dissection (CND) in patients affected by papillary thyroid carcinoma (PTC) without clinical or ultrasonographic (US) evidence of neck lymph node metastasis (cN0) is currently debated. The aim of this study was to evaluate long-term outcome of CND on locoregional recurrence, distant metastasis, survival, and postoperative complications in a large series of patients with cN0-PTC.

    Study Design: Observational retrospective controlled study. Read More

    Impact of genotype on endocrinal complications of Children with Alpha-thalassemia in China.
    Sci Rep 2017 Jun 7;7(1):2948. Epub 2017 Jun 7.
    Department of Clinical Laboratory, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China.
    Alpha-thalassemia occurs with high frenquency in China. Four common α-globin gene deletion mutations (-SEA, -α3.7, and -α4. Read More

    Recurrent laryngeal nerve injury and hypoparathyroidism rates in reoperative thyroid surgery.
    Turk J Surg 2017 1;33(1):14-17. Epub 2017 Mar 1.
    General Practitoner, Boatni Health Center, Benghazi, Libya.
    Objective: Reoperative thyroid surgery is rare and has a high complication rate. This retrospective cohort study was performed to determine the recurrent laryngeal nerve injury and hypoparathyroidism rates after reoperative thyroid surgery in two university hospitals in Benghazi, Libya.

    Material And Methods: All consecutive patients who underwent reoperative thyroid surgery between January 2002 and July 2014 were included retrospectively. Read More

    Teaching NeuroImages: Fahr syndrome caused by hypoparathyroidism.
    Neurology 2017 Jun;88(23):e233
    From the Department of Internal Medicine (E.D., V.S.-J., N.A.H., A.L.B.), Hôpital Universitaire de Mirebalais, Haiti; Departments of Internal Medicine (N.A.H.) and Neurology (A.L.B.), Brigham and Women's Hospital; and Harvard Medical School (N.A.H., A.L.B.), Boston, MA.

    GAD antibody-associated limbic encephalitis in a young woman with APECED.
    Endocrinol Diabetes Metab Case Rep 2017 25;2017. Epub 2017 May 25.
    Max Planck Institute of Psychiatry, Clinical Neuroendocrinology Group, MunichGermany.
    The autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a genetic disorder caused by a mutation in the autoimmune regulator (AIRE) gene. Immune deficiency, hypoparathyroidism and Addison's disease due to autoimmune dysfunction are the major clinical signs of APECED. We report on a 21-year-old female APECED patient with two inactivating mutations in the AIRE gene. Read More

    Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene.
    Intern Med 2017 1;56(11):1393-1397. Epub 2017 Jun 1.
    Division of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
    Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disease caused by GATA3 mutations. Although several cases with variable renal features have been reported, the presence of histological changes within the glomeruli in adult patients is unclear. We herein report an adult case of HDR syndrome with a novel p. Read More

    Efficacy of Teriparatide in Patients with Hypoparathyroidism: A Prospective, Open-label Study.
    Indian J Endocrinol Metab 2017 May-Jun;21(3):415-418
    Department of Endocrinology, Army Hospital (R and R), New Delhi, India.
    Context: Conventional treatment of hypoparathyroidism with calcium, Vitamin D analogs, and thiazide diuretics is often suboptimal, and these patients have poor quality of life. Teriparatide (parathyroid hormone 1-34 [PTH (1-34)]), an amide of PTH, is widely available for the use in osteoporosis; however, its use in hypoparathyroidism is limited.

    Aims: The aim of this study is to evaluate the efficacy of PTH (1-34) in the treatment of patients with hypoparathyroidism. Read More

    Long-term treatment-related morbidity in differentiated thyroid cancer: a systematic review of the literature.
    Pragmat Obs Res 2017 16;8:57-67. Epub 2017 May 16.
    Department of Oncology and Metabolism.
    Background: Differentiated thyroid cancer (DTC) occurs in relatively young patients and is associated with a good prognosis and long survival. The management of this disease involves thyroidectomy, radioiodine therapy, and long-term thyroid-stimulating hormone suppression therapy (THST). The long-term effects of the treatment and the interaction between subclinical hyperthyroidism and long-term hypoparathyroidism are poorly understood. Read More

    Harefuah 2017 Mar(3):167-170
    Department of Surgery, Hillel Yaffe Medical Center, Hadera.
    Introduction: The indications and methods of parathyroid autotransplantation in children and adults are reviewed, with special emphasis on the methods of immediate transplantation and delayed autotransplantation after cryopreservation. Parathyroid autotransplantation is performed during surgery when all four parathyroid glands have been intentionally resected in parathyroid hyperplasia, or when all four glands were inadvertently damaged during total thyroidectomy, or recurrent neck surgery. When parathyroid damage is suspected during thyroid or extensive neck surgery, cryopreservation of a parathyroid gland is performed. Read More

    A new mutation site in the AIRE gene causes autoimmune polyendocrine syndrome type 1.
    Immunogenetics 2017 May 24. Epub 2017 May 24.
    Department of Endocrinology, China Three Gorges University & Yichang Central People's Hospital, Yi Ling Road 181, Yichang, 443003, China.
    Autoimmune polyendocrine syndrome type 1 (APS-1, OMIM 2403000) is a rare autosomal recessive disease that is caused by autoimmune regulator (AIRE). The main symptoms of APS-1 are chronic mucocutaneous candidiasis, autoimmune adrenocortical insufficiency (Addison's disease) and hypoparathyroidism. We collected APS-1 cases and analysed them. Read More

    Analysis of factors affecting the development of hypocalcaemia after multinodular goitre surgery.
    Pol Przegl Chir 2017 Apr;89(2):26-30
    3 University Reaserch Hospital named after professor Kornel Gibiński of the Medical Univeristy of Silesia in Katowice, Ward of Alimentary Canal Surgery, Ward supervisor prof. Paweł lampe.
    Introduction: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. Read More

    Safety and Cost-Effectiveness in Thyroidectomy Using the HARMONIC Scalpel Compared to Traditional Hemostasis: A Controlled Clinical Assay.
    Surg Technol Int 2017 Jul;30:141-147
    General Surgery Department, Neck Surgery Clinic Hospital General de México OD, México D.F., México.
    Introduction: The aim of this clinical control trial is to analyze the cost-effectiveness and to understand the efficacy of the HARMONIC FOCUS®+ (Ethicon Inc., Somerville, New Jersey) scalpel as the only system to cut and coagulate in thyroidectomy.

    Materials And Methods: One hundered patients of the thyroid clinic of the Mexico City General Hospital were included. Read More

    A Novel De novo GATA-binding Protein 3 Mutation in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome.
    Chin Med J (Engl) 2017 Jun;130(11):1378-1380
    Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

    Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases.
    J Hum Genet 2017 May 18. Epub 2017 May 18.
    Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan.
    Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder of mitochondrial fatty-acid oxidation. Isolated long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is often reported in Caucasian countries due to a common mutation. However, the molecular and clinical basis of complete TFP deficiency has not been extensively reported. Read More

    Treatment of severe hypocalcaemia due to osteoblastic metastases in a patient with post-thyroidectomy hypoparathyroidism with (153)Sm-EDTMP.
    BMJ Case Rep 2017 May 16;2017. Epub 2017 May 16.
    National and Kapodistrian University of Athens - Faculty of Medicine, , Athens, Greece.
    Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with (153)Sm. Read More

    Timing and extension of lymphadenectomy in medullary thyroid carcinoma: A case series from a single institution.
    Int J Surg 2017 May;41 Suppl 1:S70-S74
    University of Perugia, Medical School, Endocrine Surgery Unit, S. Maria University Hospital, Terni, Italy. Electronic address:
    Background: Medullary thyroid carcinoma is an aggressive tumor and presents with significant morbidity and mortality and a high rate of lymph node metastases. The combination of total thyroidectomy and cervical lymphadenectomy is the essential treatment for those patients presenting with cervical lymph node metastases.

    Materials And Methods: A retrospective analysis of 117 patients operated for medullary thyroid carcinoma over a period of 15 years at a single institution. Read More

    Concurrent endocrine and other surgical procedures: an institutional experience.
    J Surg Res 2017 May 22;211:107-113. Epub 2016 Dec 22.
    Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin Milwaukee, WI. Electronic address:
    Inroduction: The number of endocrine procedures, specifically parathyroidectomy, thyroidectomy, and adrenalectomy, being performed is increasing. There is a paucity of literature on the feasibility of combining these procedures with other surgical procedures. Therefore, the aim of this study was to determine the effect of performing concurrent surgical procedures on postoperative outcomes. Read More

    Superior parathyroid gland approach to the recurrent laryngeal nerve.
    Head Neck 2017 Jul 11;39(7):1287-1290. Epub 2017 May 11.
    Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: The superior parathyroid gland is known to be almost constant in its location under the false thyroid capsule. Could it be a landmark to point to the site of incision of the false thyroid capsule and find the plane of the recurrent laryngeal nerve (RLN) during thyroidectomy?

    Methods: The study included 48 patients with benign goiter scheduled for hemithyroidectomy or total thyroidectomy; there were 16 cases of solitary thyroid nodules, 27 cases of multinodular goiter, and 5 cases of toxic goiter.

    Results: This study included 80 lobectomies. Read More

    Screening for Thyroid Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
    JAMA 2017 05;317(18):1888-1903
    Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Research Affiliates Evidence-based Practice Center, Seattle, Washington.
    Importance: The incidence of detected thyroid cancer cases has been increasing in the United States since 1975. The majority of thyroid cancers are differentiated cancers with excellent prognosis and long-term survival.

    Objective: To systematically review the benefits and harms associated with thyroid cancer screening and treatment of early thyroid cancer in asymptomatic adults to inform the US Preventive Services Task Force. Read More

    Epidemiology, management and outcomes of Graves' disease-real life data.
    Endocrine 2017 Jun 6;56(3):568-578. Epub 2017 May 6.
    Endocrine Surgery Unit, Directorate of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Purpose: Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surgery in Graves' disease. Read More

    Robotic thyroidectomy and parathyroidectomy: An initial experience with retroauricular approach.
    Head Neck 2017 Aug 5;39(8):1568-1572. Epub 2017 May 5.
    Division of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana.
    Background: New approaches for robotic-assisted thyroidectomy were recently described. The purpose of this study was to present the report of our initial experience using a retroauricular approach for thyroid and parathyroid surgeries.

    Methods: This is a prospective study that was conducted under institutional review board approval and all surgeries were performed by a single surgeon at a North American academic institution. Read More

    Population-Based Assessment of Complications following Surgery for Thyroid Cancer.
    J Clin Endocrinol Metab 2017 Apr 28. Epub 2017 Apr 28.
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
    Context: As thyroid cancer incidence rises, more patients undergo thyroid surgery. Although post-operative complication rates have been reported in single institution studies, population-based data is limited.

    Objective: Determine thyroid cancer surgery complication rates and identify at-risk populations. Read More

    Childhood Polyarthritis As Early Manifestation of Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy Syndrome.
    Front Immunol 2017 18;8:377. Epub 2017 Apr 18.
    Division of Pediatric Rheumatology, Penn State Children's Hospital, Hershey, PA, USA.
    Autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) is a rare disorder of immune dysregulation caused by mutations in the autoimmune regulator (AIRE) gene. Individuals affected with APECED develop a clinical syndrome characterized by ectodermal abnormalities, autoantibody production, and organ-specific autoimmune manifestations. Inflammatory arthritis is usually not described as a part of the syndrome, and only sporadic cases are reported. Read More

    Optimal extent of prophylactic central neck dissection for papillary thyroid carcinoma: Comparison of unilateral versus bilateral central neck dissection.
    Asian J Surg 2017 Apr 25. Epub 2017 Apr 25.
    Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Republic of Korea. Electronic address:
    Objective: The aim of the study was to determine the optimal extent of prophylactic central neck dissection (pCND) in papillary thyroid carcinoma (PTC).

    Materials And Methods: We studied 384 patients with clinically node-negative unilateral PTC who had undergone total thyroidectomy with pCND. Of these, 169 patients underwent unilateral pCND, and 215, bilateral pCND. Read More

    [Fahr syndrome secondary to primary hypoparathyroidism: about a case].
    Pan Afr Med J 2017 4;26. Epub 2017 Jan 4.
    Service de Biochimie-Toxicologie, Hôpital Militaire Moulay Ismail Meknès, Maroc.
    Fahr syndrome is a rare anatomo-clinic disease whose most common cause is primary or postoperative hypoparathyroidism. It is characterized by bilateral and symmetrical intracerebral calcifications located in the central gray nuclei, most often associated with phosphocalcium metabolism disorders. We here report the case of a 54-year old patient who had been treated for primary hypoparathyroidism for 20 years, presenting with amnesic disorders revealing Fahr syndrome secondary to hypoparathyroidism. Read More

    22q11.2 deletion syndrome lowers seizure threshold in adult patients without epilepsy.
    Epilepsia 2017 Jun 27;58(6):1095-1101. Epub 2017 Apr 27.
    Division of Neurology, Department of Medicine, Toronto Western Hospital, Krembil Neuroscience Centre, University of Toronto, Toronto, Ontario, Canada.
    Objective: Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. Read More

    Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study.
    Endocr Connect 2017 Jul 26;6(5):289-296. Epub 2017 Apr 26.
    Departments of EndocrinologySanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Objective: Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder characterized by progressive organ-specific autoimmunity. There is scant information on APS1 in ethnic groups other than European Caucasians. We studied clinical aspects and autoimmune regulator (AIRE) gene mutations in a cohort of Indian APS1 patients. Read More

    Endocrine Complications of Surgical Treatment of Thyroid Cancer: An Update.
    Exp Clin Endocrinol Diabetes 2017 Apr 25. Epub 2017 Apr 25.
    Department of Endocrinology. Hospital Ramón y Cajal, Madrid (Spain).
    Postoperative hypoparathyroidism (HypoPT) and hypothyroidism (HypoT) are the main endocrine complications after the surgical treatment for thyroid cancer. Postsurgical HypoPT can be transient, protracted or permanent. Its frequency varies according to the underlying cervical pathology, surgical technique, and mainly the experience of the surgeon. Read More

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