8,657 results match your criteria Hypoparathyroidism


Microencapsulated Parathyroid Allotransplantation in the Omental Tissue.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.

Background: Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathormone level. Conventional treatment requires life-long medication, and daily drug usage has some side-effects. To avoid this circumstance, transplantation is an alternative and curative option. Read More

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http://dx.doi.org/10.1111/aor.13475DOI Listing

Aluminum toxicity to bone: A multisystem effect?

Authors:
Gordon L Klein

Osteoporos Sarcopenia 2019 Mar 15;5(1):2-5. Epub 2019 Feb 15.

Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX, USA.

Aluminum (Al) is the third most abundant element in the earth's crust and is omnipresent in our environment, including our food. However, with normal renal function, oral and enteral ingestion of substances contaminated with Al, such as antacids and infant formulae, do not cause problems. The intestine, skin, and respiratory tract are barriers to Al entry into the blood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055255183017
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http://dx.doi.org/10.1016/j.afos.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453153PMC
March 2019
2 Reads

Preoperative charcoal suspension tattoo for the detection of differentiated thyroid cancer recurrence.

Mol Clin Oncol 2019 May 15;10(5):524-530. Epub 2019 Mar 15.

Department of Pathology, Santa Maria delle Croci Hospital, AUSL of Romagna, I-48121 Ravenna, Italy.

Recurrent differentiated thyroid carcinoma can easily be detected by means of ultrasound (US) and thyroglobulin, and often requires further surgical intervention. Revision surgery is often a technical challenge with significant risk of complications, considering the altered anatomy, with a possibility of leaving behind residual neoplasm. Preoperative US-guided tattooing localization has been introduced to reduce and prevent these potential problems during revision surgery. Read More

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http://dx.doi.org/10.3892/mco.2019.1826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466997PMC
May 2019
1 Read

HLA Class I Expression Changes in Different Types of Cultured Parathyroid Cells.

Exp Clin Transplant 2019 Apr 17. Epub 2019 Apr 17.

From the Experimental Research Center, Bezmialem Vakif University, Istanbul, Turkey.

Objectives: Tissue-specific immunogenicity can be characterized by the determination of human leukocyte antigens (HLA). Parathyroid hyperplasia tissue cells are presumed to have the ability to lose HLA class I expression profile during cultivation, whereas healthy parathyroid cells are presumed to already express HLA class I molecules at low levels. However, there are conflicting results about the expression of HLA class I antigens. Read More

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http://www.ectrx.org/detail/epub/1/1/1/0/801/0
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http://dx.doi.org/10.6002/ect.2018.0388DOI Listing
April 2019
1 Read

Correction to: Hypoparathyroidism After Total Thyroidectomy: Importance of the Intraoperative Management of the Parathyroid Glands.

World J Surg 2019 Apr 15. Epub 2019 Apr 15.

Service of Endocrine and Advanced Laparoscopic Surgery/Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, 14000, Mexico City, Mexico.

In the original version of the article, the last three column headings in Table 3 were mislabeled. The original article has been corrected. Following is the corrected table. Read More

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http://dx.doi.org/10.1007/s00268-019-05002-1DOI Listing
April 2019
1 Read

Preventive Effect of Dexamethasone Therapy on the Transient Hypoparathyroidism through Total Thyroidectomy.

Iran J Otorhinolaryngol 2019 Mar;31(103):73-80

Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: This study aimed to investigate whether pre-operative dexamethasone could ameliorate transient hypoparathyroidism outcome through total thyroidectomy.

Materials And Methods: This randomized clinical trial study was conducted on 128 patients underwent total thyroidectomy from March 2014 to April 2015. Patients were randomly assigned to two groups of experimental receiving 8 mg IV of intravenous dexamethasone (n=45) 45 min before skin incision treatment and control (n=83). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449529PMC
March 2019
1 Read

Structure and dynamics of the active human parathyroid hormone receptor-1.

Science 2019 04;364(6436):148-153

Department of Pathology of Sir Run Run Shaw Hospital and Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.

The parathyroid hormone receptor-1 (PTH1R) is a class B G protein-coupled receptor central to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. Here we report the cryo-electron microscopy structure of human PTH1R bound to a long-acting PTH analog and the stimulatory G protein. The bound peptide adopts an extended helix with its amino terminus inserted deeply into the receptor transmembrane domain (TMD), which leads to partial unwinding of the carboxyl terminus of transmembrane helix 6 and induces a sharp kink at the middle of this helix to allow the receptor to couple with G protein. Read More

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http://dx.doi.org/10.1126/science.aav7942DOI Listing
April 2019
1 Read
31.477 Impact Factor

[Risk factors for hypoparathyroidism after thyroidectomy].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):315-321

Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the risk factors for hypoparathyroidism after thyroidectomy.
 Methods: Clinical data of 492 patients, who underwent thyroidectomy from April 2015 to December 2016 from Xiangya Hospital of Central South University, were studied retrospectively. Chi-square test and multivariable logistic regression were performed to find the risk factors for postoperative hypoparathyroidism. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.03.013DOI Listing
March 2019
1 Read

Current Practice of Surgery for Benign Goitre-An Analysis of the Prospective DGAV StuDoQ|Thyroid Registry.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Department of Visceral-, Vascular and Endocrine Surgery, University Medical Centre Halle, 06120 Halle, Germany.

Background: To evaluate the current indications, resection strategies and short-term outcomes of surgery for benign goitre in a country with endemic goitre.

Methods: Data of patients who underwent surgery for benign goitre were retrieved from the prospective StuDoQ/Thyroid registry and retrospectively analysed regarding the patient's demographics, indications for surgery, surgical procedures, histology, and perioperative outcomes.

Results: In a 15-month period, 12,888 patients from 83 departments underwent thyroid resections for benign conditions. Read More

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http://dx.doi.org/10.3390/jcm8040477DOI Listing
April 2019
1 Read

Routine low-dose calcium supplementation after thyroidectomy does not reduce the rate of symptomatic hypocalcemia: a prospective randomized trial.

Ann Surg Treat Res 2019 Apr 28;96(4):177-184. Epub 2019 Mar 28.

Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea.

Purpose: Routine supplementation of high-dose calcium significantly decreased the risk of postoperative symptomatic hypocalcemia after thyroidectomy. However, there is an ongoing debate about whether the same results can be achieved with low-dose calcium supplementation.

Methods: Patients (n = 138) who underwent total thyroidectomy for thyroid cancer were 1:1 randomly assigned to receive oral supplements of 1,500 mg/day elemental calcium and 1,000 IU/day cholecalciferol for 2 weeks or no supplementation. Read More

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http://dx.doi.org/10.4174/astr.2019.96.4.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444042PMC
April 2019
3 Reads

Complications after reoperative thyroid surgery: retrospective evaluation of 152 consecutive cases.

Updates Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgical Sciences, University of Cagliari, Cittadella Universitaria, SS554, Bivio Sestu, 09042, Monserrato, CA, Italy.

Reoperative thyroid surgery is an uncommon procedure that is indicated in recurrent benign or malignant disease. It is associated with a high complication rate, especially of hypoparathyroidism and recurrent nerve palsy. We retrospectively reviewed our series of patients on whom reoperative thyroid surgery was performed and we compared this group with patients who underwent primary thyroidectomies. Read More

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http://dx.doi.org/10.1007/s13304-019-00647-yDOI Listing
April 2019
2 Reads

Parathyroid Diseases.

Authors:
Scott A Sullivan

Clin Obstet Gynecol 2019 Jun;62(2):347-358

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Although uncommon in pregnancy, parathyroid dysfunction may produce significant perinatal and maternal morbidity and mortality. The prevalence of hyperparathyroidism is 0.5%. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000447DOI Listing
June 2019
1 Read

Hypoparathyroidism After Total Thyroidectomy: Importance of the Intraoperative Management of the Parathyroid Glands.

World J Surg 2019 Mar 27. Epub 2019 Mar 27.

Service of Endocrine and Advanced Laparoscopic Surgery/Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, 14000, Mexico City, Mexico.

Background: Total thyroidectomy is the most common surgical procedure for the treatment of thyroid diseases. Postoperative hypocalcemia/hypoparathyroidism is the most frequent complication after total thyroidectomy. The aim of this study was to evaluate the rate of postoperative hypocalcemia and permanent hypoparathyroidism after total thyroidectomy in order to identify potential risk factors and to evaluate the impact of parathyroid autotransplantation. Read More

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http://dx.doi.org/10.1007/s00268-019-04987-zDOI Listing
March 2019
1 Read

[Surgical management of hyperthyroidism: about 60 cases].

Pan Afr Med J 2018 20;31:43. Epub 2018 Sep 20.

Service d'Oto-Rhino-Laryngologie, Hôpital Militaire Avicenne, Marrakech, Maroc.

Hyperthyroidism includes several diseases characterized by high level of circulating thyroid hormones. Thyroidectomy is one of the main treatment options. We conducted a retrospective study to evaluate the epidemiological, clinical, therapeutic, evolutionary features of patients who had undergone surgery for hyperthyroidism in the ENT Department at the Avicenne Military Hospital in Marrakech. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.43.16695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430848PMC
April 2019
1 Read

Effects of Supplemental Perioperative Oxygen in Preventing Transient Hypoparathyroidism After Total Thyroidectomy.

Cureus 2018 Oct 11;10(10):e3440. Epub 2018 Oct 11.

Surgery, Holy Family Hospital, Rawalpindi, PAK.

Background Thyroidectomy is one of the most common endocrine procedures performed worldwide. Post-operative hypocalcemia is a troublesome complication of thyroid surgery. Few studies have considered the role of supplemental oxygen in preventing postoperative hypocalcemia in patients undergoing thyroidectomy. Read More

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http://dx.doi.org/10.7759/cureus.3440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433448PMC
October 2018
1 Read

Primary immunodeficiencies in adults.

Authors:
Jiří Litzman

Vnitr Lek 2019 ;65(2):109-116

In contrast to general opinion, the issue of primary immunodeficiency is far from just a pediatric medicine; a large number of patients with primary immunodefciencies are not only treated, but also diagnosed in adulthood. The most important manifestation of these diseases are serious, unusual or ill-treatable infections. Some primary immune deficiency diseases manifest themselves in adulthood - mainly common variable immunodeficiency (CVID) and Goods syndrome (hypogammaglobulinemia with thymoma). Read More

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January 2019
1 Read

Quantitative Assessment of the Learning Curve for Robotic Thyroid Surgery.

J Clin Med 2019 Mar 22;8(3). Epub 2019 Mar 22.

Department of Surgery, Ewha Womans University Medical Center, 1071 Anyangcheon-ro, Yangcheon-Gu, Seoul 07985, Korea.

With the increased utilization of robot thyroidectomy in recent years, surgical proficiency is the paramount consideration. However, there is no single perfect or ideal method for measuring surgical proficiency. In this study, we evaluated the learning curve of robotic thyroidectomy using various parameters. Read More

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http://dx.doi.org/10.3390/jcm8030402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463185PMC
March 2019
1 Read

Surgical management of pediatric thyroid disease: Complication rates after thyroidectomy at the Children's Hospital of Philadelphia high-volume Pediatric Thyroid Center.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: Recent studies suggest improved outcomes for children undergoing thyroidectomy at high-volume pediatric surgery centers. We present outcomes after thyroid surgery at a single center and advocate for referral to high-volume centers for multidisciplinary management of these children.

Methods: Medical records were reviewed for all pediatric patients undergoing thyroid surgery at a single institution from 2009 through 2017. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.009DOI Listing
February 2019
1 Read

Could the Less-Than Subtotal Parathyroidectomy Be an Option for Treating Young Patients With Multiple Endocrine Neoplasia Type 1-Related Hyperparathyroidism?

Front Endocrinol (Lausanne) 2019 7;10:123. Epub 2019 Mar 7.

Endocrine Genetics Unit (LIM-25), Endocrinology Division, Hospital das Clinicas, University of Sao Paulo School of Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

The surgical treatment of primary hyperparathyroidism (HPT) in patients with multiple endocrine neoplasia type 1 (MEN1) has evolved due the concern of permanent hypoparathyroidism. As the diagnosis has increased, the extent of operation has decreased. Most MEN1 patients requiring parathyroidectomy are younger than 50 years and they pose a difficult balance to achieve between persistent HPT and life-long hypoparathyroidism. Read More

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http://dx.doi.org/10.3389/fendo.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417394PMC
March 2019
2 Reads

Superior parathyroid blood supply safety in thyroid cancer surgery: A randomized controlled trial.

Int J Surg 2019 Apr 12;64:33-39. Epub 2019 Mar 12.

Department of ICU, Jining No. 1 People's Hospital, No. 6, Jiankang Road, Jiningy, 272011, Shandong, People's Republic of China. Electronic address:

Background: To evaluate the clinical value of a technique protecting blood supply to the superior parathyroid during surgery for thyroid cancer.

Materials And Methods: The observation group comprised 113 patients admitted to our hospital during the period from January 1, 2016 to December 31, 2016, who were diagnosed with thyroid cancer and treated by surgery using a technique protecting blood supply to the superior parathyroid. The control group comprised 113 patients diagnosed with thyroid cancer who were treated by surgery using the conventional technique. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.019DOI Listing

CRYOPRESERVATION OF PARATHYROID TISSUE: A WHITE PAPER ON ESTABLISHING A LOCAL SERVICE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

Andrology Laboratory and Sperm Bank, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland.

Objectives: Preservation of parathyroid function is one of the primary tenets of endocrine surgery. For patients with thyroid disease, an inadvertently compromised parathyroid gland is routinely auto transplanted into the neck at the time of surgery. By contrast for patients with parathyroid disease secondary to hyperplasia, the timing of auto transplantation needs to be further considered in order to balance the risks between persistent disease and permanent hypocalcaemia. Read More

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http://dx.doi.org/10.4158/EP-2018-0547DOI Listing
March 2019
7 Reads

Stratifying the risk factors for hypoparathyroidism after total thyroidectomy. A single Center study.

Ann Ital Chir 2019 ;90:21-30

Background: Post-operative hypoparathyroidism is a complication in patients who undergo thyroid surgery. Our study aimed to evaluate the incidence and causes of post-operative transient and permanent hypoparathyroidism in patients undergoing thyroid surgery.

Materials And Methods: The data of 933 consecutive patients who underwent total thyroidectomy in a single center were retrospectively evaluated. Read More

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January 2019
2 Reads

A prospective follow-up study on completion thyroidectomy for well-differentiated thyroid cancer. A single-center report.

Ann Ital Chir 2019 ;90:14-20

Background: Completion thyroidectomy (cT) becomes a choice after any type of less than total thyroid surgery, when a "total" would have been indicated on primary intervention if malignancy diagnosis had been available. The study main aim is to define predictive factors of malignancy in the thyroid remnant and to assess the morbidity risk after cT according to the type of initial intervention.

Material And Method: Sixty-three patients on whom cT was performed were finally included with 61 surgeries performed in our department. Read More

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January 2019
1 Read

Transoral endoscopic thyroidectomy using vestibular approach: A single center experience.

J Postgrad Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Seth GS Medical College, Parel, Mumbai, Maharashtra, India.

Background: Thyroid Natural Orifice Transluminal Endoscopic Surgery (NOTES) or transoral endoscopic thyroidectomy using vestibular approach is a recent advance embraced by the surgical community because of its potential for a scar-free thyroidectomy. In this article, we present our initial experience with this technique.

Materials And Methods: We used a three-port technique through the oral vestibule, one 10 mm port for the laparoscope and two additional 5 mm ports for the endoscopic instruments required. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_117_18DOI Listing
March 2019
2 Reads

Age-Related Trends of Patients Undergoing Thyroidectomy: Analysis of US Inpatient Data from 2005 to 2013.

Otolaryngol Head Neck Surg 2019 Mar 29;160(3):457-464. Epub 2019 Jan 29.

1 Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Objectives: As the country ages, thyroidectomies can be expected to be performed more frequently among the elderly. In this study, we stratified patients by age to explore demographics and complications of patients undergoing thyroidectomy.

Study Design: Retrospective study with a national database. Read More

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http://dx.doi.org/10.1177/0194599818825455DOI Listing
March 2019
4 Reads

Routine bilateral neck exploration and four-gland dissection remains unnecessary in modern parathyroid surgery.

Laryngoscope Investig Otolaryngol 2019 Feb 28;4(1):188-192. Epub 2018 Nov 28.

Department of Otolaryngology-Head and Neck Surgery Augusta University Augusta Georgia.

Objective: Recent advances in preoperative imaging techniques and intraoperative parathyroid hormone (ioPTH) assays have made single-gland, minimally invasive parathyroidectomy (MIP) the preferred treatment option for most patients with primary hyperparathyroidism (pHPT). Despite this evolution, a recommendation for bilateral neck exploration (BNE) with four-gland dissection in all patients has recently been advocated by a parathyroid surgical group. The current study compares the long-term outcomes of MIP with those of conventional BNE with four-gland dissection in patients with pHPT. Read More

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http://dx.doi.org/10.1002/lio2.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383449PMC
February 2019
3 Reads

The role of thymus preservation in parathyroid gland function and surgical completeness after bilateral central lymph node dissection for papillary thyroid cancer: A randomized controlled study.

Int J Surg 2019 Feb 26;65:1-6. Epub 2019 Feb 26.

Department of General Surgery of Changzheng Hospital Affiliated to Second Military Medical University, 200003, Shanghai, China. Electronic address:

Background: The clinical value of thymus preservation during thyroid carcinoma surgery remains unclear. The aim of this study is to explore the role of bilateral thymus preservation in parathyroid glands (PGs) function and surgical completeness in total thyroidectomy (TT) with bilateral central lymph node dissection (CLND).

Materials And Methods: Fifty-four consecutive patients who underwent TT and bilateral CLND were assigned to the thymus preservation (TP) group (n = 27) and the bilateral thymectomy (BT) group (n = 27). Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.013DOI Listing
February 2019
3 Reads

[Wnt signaling and bone metabolic diseases.]

Clin Calcium 2019;29(3):329-336

Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Wnt signaling is known to be involved in metabolic bone disorders. Serum levels of sclerostin, a bone-specific protein that inhibits Wnt signaling, have been investigated in a variety of metabolic bone disorders. Serum sclerostin levels are positively correlated with bone mineral density in patients with osteoporosis. Read More

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http://dx.doi.org/10.20837/4201903329DOI Listing
January 2019
1 Read

Is calcium supplementation always needed in patients with hypoparathyroidism?

Clin Endocrinol (Oxf) 2019 Feb 23. Epub 2019 Feb 23.

The Royal Victoria Infirmary, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Oral calcium salts are recommended for the treatment of chronic hypoparathyroidism (HypoPT), although dosimetry is variable between individual patients and clinicians. However, patient feedback on calcium salts can be negative, particularly due to gastrointestinal side effects and hypercalciuria-related complications. We begin with a clinical case of a HypoPT patient taking oral calcium salts following thyroid surgery, who requested support in reducing her dose of these with a view to stopping entirely. Read More

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http://dx.doi.org/10.1111/cen.13955DOI Listing
February 2019
2 Reads

Three cases of transient neonatal pseudohypoparathyroidism.

Sudan J Paediatr 2018 ;18(2):42-47

Department of Clinical Biochemistry, Klatovy Hospital, Klatovy, Czech Republic.

Neonatal hypocalcemia is defined as serum calcium (S-Ca) < 2.0 mmol/l in full-term newborns and <1.75 mmol/l in preterm newborns. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=289314
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http://dx.doi.org/10.24911/SJP.106-1516889879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378568PMC
January 2018
8 Reads

[Risk Factors for Permanent Postoperative Hypoparathyreoidism].

Zentralbl Chir 2019 Feb 22. Epub 2019 Feb 22.

Klinik für Allgemein- u. Viszeralchirurgie mit Sektion Proktologie, Raphaelsklinik Münster, Deutschland.

Background: Permanent postoperative hypoparathyreoidism remains the most frequent complication after total thyreoidectomy with severe long-term morbidity, impairment of quality of life and economic implications.

Objective: Identification of risk factors for permanent postoperative hypoparathyreoidism.

Material And Methods: 420 patients received total thyreoidectomy in our endocrine centre between 08/2012 und 08/2014, of whom 382 were included in the study. Read More

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http://dx.doi.org/10.1055/a-0837-1013DOI Listing
February 2019

Experience of thyroid surgery at tertiary referral centers in Jazan Hospitals, Saudi Arabia.

Interv Med Appl Sci 2018 Dec;10(4):198-201

Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Prince Mohammed bin Nasser Hospital, Jazan, Saudi Arabia.

Background: Benign multinodular goiter (BMNG) is a common disease of the thyroid gland with palpable thyroid nodules that may be detected in 0.8%-1.5% of men and 5. Read More

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http://dx.doi.org/10.1556/1646.10.2018.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376351PMC
December 2018
1 Read

Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma.

J Immunother Cancer 2019 Feb 21;7(1):52. Epub 2019 Feb 21.

Department of Internal Medicine, Division of Medical Oncology, Basel, Switzerland.

Background: Treatment with a combination of PD-1 and CTLA-4 targeted checkpoint inhibition has improved outcome of melanoma patients and led to durable remissions but is also associated with significant toxicities. Endocrinopathies such as thyroiditis and hypophysitis are often seen, but other, rarer disturbances have also been described. Endocrinopathies affecting the parathyroid gland are rarely reported and no clear pathomechanism has been proposed. Read More

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http://dx.doi.org/10.1186/s40425-019-0528-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385398PMC
February 2019
1 Read

Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review.

Endocrine 2019 Apr 20;64(1):176-183. Epub 2019 Feb 20.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Purpose: The reported incidence of post surgical hypoparathyroidism (HypoPT) varies greatly. Previous research suggests that the definition of HypoPT is not consistent in the literature. We therefore conducted a systematic review to investigate how HypoPT is defined and whether this definition, as well as the selected threshold for hypocalcemia affects the incidence. Read More

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http://dx.doi.org/10.1007/s12020-019-01858-4DOI Listing
April 2019
1 Read

Calcium management challenges in a macrosomic child with subcutaneous fat necrosis.

BMJ Case Rep 2019 Feb 19;12(2). Epub 2019 Feb 19.

Paediatric Dermatology, KK Women's and Children's Hospital, Singapore.

We present a case that illustrates the fluctuations in calcium levels to be expected while managing an infant with maternal gestational diabetes mellitus who also develops subcutaneous fat necrosis (SCFN). There is initial hypocalcaemia due to functional hypoparathyroidism, requiring judicious calcium replacement. But with increased extrarenal production of 1,25-dihydroxyvitamin D due to granulomatous inflammation of subcutaneous adipose tissue, hypercalcaemia ensues. Read More

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http://dx.doi.org/10.1136/bcr-2018-227141DOI Listing
February 2019
7 Reads

Quality of Life in Hypoparathyroidism Improves with rhPTH(1-84) Throughout 8 Years of Therapy.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Context: Treatment with calcium and vitamin D does not improve reduced quality of life (QoL) in hypoparathyroidism. rhPTH(1-84) therapy improves QoL metrics for up to 5 years. Data on QoL beyond this 5-yr time point are not available. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
Publisher Site
http://dx.doi.org/10.1210/jc.2018-02430DOI Listing
February 2019
22 Reads

Psychometric evaluation of the hypoparathyroidism symptom diary.

Patient Relat Outcome Meas 2019 29;10:25-36. Epub 2019 Jan 29.

RTI Health Solutions, Ann Arbor, MI, USA.

Purpose: To conduct an initial psychometric evaluation of the reliability and validity of the Hypoparathyroidism Symptom Diary (HPT-SD).

Patients And Methods: Data were collected during a cross-sectional, observational study. Participants with self-reported hypoparathyroidism (HPT) completed the HPT-SD, the Functional Assessment in Cancer Therapy-Cognitive Function (FACT-Cog), the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), and the Hospital Anxiety and Depression Scale (HADS) measures. Read More

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http://dx.doi.org/10.2147/PROM.S179310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357884PMC
January 2019
12 Reads

Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019
8 Reads

Robotic transoral thyroidectomy: Total thyroidectomy and ipsilateral central neck dissection with da Vinci Xi Surgical System.

Head Neck 2019 May 13;41(5):1536-1540. Epub 2019 Feb 13.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Transoral approach for thyroidectomy draws attention recently among the thyroid surgeons, with the merits of cosmetic outcomes and minimal flap dissection. The aim of this study is to demonstrate the details and the steps of transoral robotic thyroidectomy.

Methods: We made three incisions in the gingival-buccal sulcus for three 8-mm intraoral ports: one inverted U-shaped 1-cm midline incision approximately 2 cm above the frenulum, and two 0. Read More

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http://dx.doi.org/10.1002/hed.25661DOI Listing

Posterior reversible encephalopathy syndrome due to hypercalcaemia: a rare cause.

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2017-223415DOI Listing
February 2019
13 Reads

New advances of ICG angiography in parathyroid identification.

Authors:
Hao Jin Min Cui

Endocr Metab Immune Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

The Second Department of General Surgery, Zhuhai People's Hospital, No. 79 of Kangning Road, Xiangzhou District, Zhuhai City, Guangdong Province, 519000. China.

Objective: For surgeons, locating the parathyroid in thyroidectomy and parathyroidectomy is critical since the parathyroid plays an important role in calcium balance. The fluorescence of the parathyroid has already been found by researchers and the angiography equipment detecting the fluorescence of the parathyroid with indocyanine green has been widely applied. Using the indocyanine green angiography and looking at the actual fluorescence of in vivo and in vitro tissues, it was possible to identify the thyroid, parathyroid, lymph nodes and fat tissues during the surgical procedure. Read More

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http://dx.doi.org/10.2174/1871530319666190206212456DOI Listing
February 2019
11 Reads

Pharyngeal pouch: comparison of surgical treatment with botulinum toxin injection to the cricopharyngeus.

Authors:
K Lau M G Watson

J Laryngol Otol 2019 Feb 6;133(2):125-128. Epub 2019 Feb 6.

Department of ENT,Doncaster Royal Infirmary,UK.

Background: Pharyngeal pouch surgical treatments can be carried out via an endoscopic or open approach. Injection of botulinum toxin into the cricopharyngeus was first described as an alternative treatment to the more invasive surgical procedures performed for cricopharyngeal dysfunction. It has not been previously described as a treatment option for pharyngeal pouch. Read More

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http://dx.doi.org/10.1017/S0022215119000124DOI Listing
February 2019
10 Reads

Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 5:194599819829052. Epub 2019 Feb 5.

1 Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.

Objective: The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies. Read More

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http://dx.doi.org/10.1177/0194599819829052DOI Listing
February 2019
2 Reads

Parathyroid autotransplantation at a novel site for better evaluation of the grafted gland function: study protocol for a prospective, randomized controlled trial.

Trials 2019 Jan 31;20(1):96. Epub 2019 Jan 31.

Department of Thyroid and Breast Surgery, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, China.

Background: Hypoparathyroidism is one of the most common complications encountered in thyroidectomy. In addition to parathyroid in-situ preservation, parathyroid autotransplantation (PA) is another important remedial method for patients whose parathyroid glands have been removed. However, an accurate evaluation method for the function of a transplanted parathyroid is lacking. Read More

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http://dx.doi.org/10.1186/s13063-019-3195-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357396PMC
January 2019
1 Read
2.117 Impact Factor

[Application of carbon nano-particles in total thyroidectomy combined with lymphadenectomy in area Ⅵ].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):28-32

Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To evaluate the effects of staining with carbon nanoparticles on the identification of parathyroid glands and lymph nodes during thyroid carcinoma surgery combined with lymphadenectomy. A total of 194 patients with papillary thyroid carcinoma who underwent thyroidectomy combined with lymphadenectomy from April 2016 to January 2018 were reviewed. Of them 104 cases were injected with carbon nanoparticles in operation area (nanocarbon group) and other 90 cases without the injection of carbon nanoparticles were as control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.007DOI Listing
January 2019

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports.

Clin Diabetes Endocrinol 2019 22;5. Epub 2019 Jan 22.

1Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.

Background: Since 2011 six immune checkpoint inhibitors (ICI) have been approved to treat patients with many advanced solid tumor and hematological malignancies to improve their prognosis. Case reports of their endocrine immune-related adverse events [irAEs]) are increasingly published as more real-world patients with these malignancies are treated with these drugs. They alert physicians of a drug's AEs (which may change during a drug's life cycle) and contribute to post-marketing safety surveillance. Read More

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https://clindiabetesendo.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s40842-018-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343255PMC
January 2019
10 Reads

Scarless neck thyroidectomy using bilateral axillo-breast approach: Initial impressions after introduction in a specialized unit and a review of the literature.

Cir Esp 2019 Feb 26;97(2):81-88. Epub 2019 Jan 26.

Department of Surgery, Mount Sinai Hospital, New York, NY, USA.

Introduction: The extracervical approach for thyroidectomy remains widely unknown in our country. Its main aim is to avoid a cervical scar while maintaining the same safety profile of conventional thyroidectomy. The objective is to communicate our experience after the first 15 cases using the endoscopic bilateral axillo-breast approach (BABA) and to review critical points described in literature. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.11.006DOI Listing
February 2019
3 Reads

Clinical presentation and management of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 12 28;32(6):927-939. Epub 2018 Sep 28.

Department of Surgery and Translational Medicine, University of Florence, Bone Metabolic Diseases Unit, University Hospital of Florence, Italy. Electronic address:

The clinical manifestations of hypoparathyroidism are variable and can involve almost any organ system. The main clinical features of the hypoparathyroidism are typically signs or symptoms due to neuromuscular irritability owing to low serum calcium level. In addition to hypocalcemia, hyperphosphatemia can contribute to long-term complications, including extra-skeletal calcifications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183010
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http://dx.doi.org/10.1016/j.beem.2018.09.007DOI Listing
December 2018
9 Reads