Search Our Scientific Publications & Authors

Langenbecks Arch Surg 2021 Jun 9. Epub 2021 Jun 9.

Getting It Right First Time Programme, NHS England and NHS Improvement, 1 Lower Marsh, London, SE1 7NT, UK.

Purpose: The delivery of surgical care in England has seen a momentum towards centralisation within larger volume hospitals and surgical teams. The aim of this study was to investigate outcomes in England in relationship to hospital and surgeon annual volumes for total thyroidectomy.

Methods: Data were extracted from the Hospital Episodes Statistics (HES) database for England. Read More

Front Surg 2021 21;8:668498. Epub 2021 May 21.

Department of General Surgery, School of Medicine, Ruijin Hospital/Lu Wan Branch, Shanghai Jiaotong University, Shanghai, China.

To analyze the risk factors of hypoparathyroidism after total thyroidectomy. Clinical data of patients who undergo total thyroidectomy in the Luwan Branch of Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University was collected from January 2015 to December 2018, retrospectively. Logistic regression was used to analyze the risk factors associated with transient and long-term hypoparathyroidism. Read More

Front Neurol 2021 20;12:679164. Epub 2021 May 20.

Department of Paediatrics, St Mary's Hospital, Kurume, Fukuoka, Japan.

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare autosomal recessive disorder caused by a mutation in the autoimmune regulator gene. Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy typically exhibit hypoparathyroidism, adrenocortical failure, and chronic mucocutaneous candidiasis. There are only a few case reports of autoimmune encephalitis during autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, but not as an initial manifestation. Read More

Surgery 2021 Jun 2. Epub 2021 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Although there are several publications on the new transoral robotic thyroidectomy technique, few have thoroughly reviewed its associated complications. This study analyzed the causes and prevention of transoral robotic thyroidectomy-specific complications and presented preventive measures.

Methods: The medical records of patients who underwent transoral robotic thyroidectomy performed by a single surgeon between March 1, 2009 and April 30, 2019 were retrospectively analyzed. Read More

Sci Rep 2021 Jun 4;11(1):11876. Epub 2021 Jun 4.

Department of General Surgery, Yıldırım Beyazıt University School of Medicine, Çankaya, Ankara, Turkey.

We aimed to investigate the prevalence of postoperative hypoparathyroidism (PoH), the relevant factors, and predictors of transient or permanent hypoparathyroidism. The files of 352 patients who underwent bilateral total thyroidectomy alone or with central lymph node dissection and/or lateral neck dissection between June 1, 2019, and November 30, 2019, were retrospectively evaluated. Also, calcium and parathyroid hormone levels measured preoperatively and 4-6 h after surgery, follow-up examination results, and time to resolution of transient PoH were recorded. Read More

Clin Case Rep 2021 May 5;9(5):e03669. Epub 2021 May 5.

Internal Medicine Hospital Senhora da Oliveira Guimarães Portugal.

Neuroimaging scan and calcium/phosphorus metabolism evaluation should be considered in patients with new onset of neuropsychiatric symptoms, to provide an earliest detection of pathological and metabolic alterations, such as Fahr's syndrome. Read More

Ital J Pediatr 2021 Jun 2;47(1):126. Epub 2021 Jun 2.

Endocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome Type 1 is a rare autosomal recessive syndrome. The disorder is caused by mutations in the AIRE (AutoImmune Regulator) gene. According to the classic criteria, clinical diagnosis requires the presence of at least two of three main components: chronic mucocutaneous candidiasis, hypoparathyroidism and primary adrenal insufficiency. Read More

Thyroid 2021 Jun 3. Epub 2021 Jun 3.

Vanderbilt University, 5718, Vanderbilt Biophotonics Center, Nashville, Tennessee, United States.

Background: Accurate assessment of parathyroid gland vascularity is important during thyroidectomy to preserve the function of parathyroid glands and prevent postoperative hypocalcemia. Laser speckle contrast imaging (LSCI) has been shown to be accurate in detecting differences in parathyroid vascularity. In this surgeon-blinded prognostic study, we evaluate the relationship between intraoperative LSCI measurements and postoperative outcomes of thyroidectomy patients. Read More

Pediatr Transplant 2021 Jun 2:e14048. Epub 2021 Jun 2.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

APS-1 is an extremely rare, autosomal recessive condition that often presents with candidiasis, adrenal insufficiency, and hypoparathyroidism. This condition is associated with autoimmune hepatitis in less than 20% of cases, and there have only been a few reports of children with the condition who developed ALF. We present a unique case of an infant with APS-1 who developed ALF and subsequently required liver transplantation. Read More

Biomedicines 2021 May 5;9(5). Epub 2021 May 5.

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 08003 Barcelona, Catalonia, Spain.

Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Read More

Clin Chem 2021 Jun;67(6):827

Department of Pathology, Oregon Health & Science University, Mailcode HRC-9, Portland.

Mol Cytogenet 2021 May 28;14(1):29. Epub 2021 May 28.

Department of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Chazhong Road 20, Taijiang District, Fuzhou, 350004, Fujian, China.

Background: Terminal deletion of chromosome 10p is a rare chromosomal abnormality. We report a neonatal case with a large deletion of 10p15.3p13 diagnosed early because of severe clinical manifestations. Read More

Front Endocrinol (Lausanne) 2021 10;12:677986. Epub 2021 May 10.

Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Objective: The association between metastasis to the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) and cN0 papillary thyroid carcinoma (PTC) located in the thyroid isthmus remains unknown; therefore, our goal was to analyze the characteristics of LN-prRLN metastasis of cN0 PTCs of the thyroid isthmus and determine its potential predictors.

Patients And Methods: This retrospective study included patients who underwent bilateral central neck dissection between January 2018 and January 2021. The specimen was divided into five groups of prelaryngeal lymph node (LN), pretracheal LN, left paratracheal LN, lymph node anterior to the right recurrent laryngeal nerve (LN-arRLN), and LN-prRLN. Read More

JAAD Case Rep 2021 Jun 23;12:40-45. Epub 2021 Mar 23.

University of Rennes 1, Rennes, France.

Osteoporos Int 2021 May 22. Epub 2021 May 22.

National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

In this meta-analysis, we analyzed 7 observational studies for assessing the fracture risk in patients with hypoparathyroidism (hypoPT). We found that the risk of vertebral fractures is increased by almost 2-fold, especially those with nonsurgical hypoPT.

Purpose: Patients with hypoPT have higher bone mineral density than age- and sex-matched controls. Read More

Updates Surg 2021 May 20. Epub 2021 May 20.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, 22110, Jordan.

The purpose is to delineate the clinico-pathologic features of papillary thyroid carcinoma (PTC) occurring in a background of Hashimoto's thyroiditis (HT). A retrospective analysis of consecutive PTC patients who underwent surgery at an academic center between Jan. 2010 and Jan. Read More

Minerva Endocrinol (Torino) 2021 05 20. Epub 2021 May 20.

Department of Medicine, Division of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA -

Hypoparathyroidism is a rare disorder characterized by hypocalcemia and deficient or absent levels of parathyroid hormone. The consequences of chronic hypoparathyroidism involve classic target organs of parathyroid hormone, namely the skeleton and the kidneys. In this article, we focus on the abnormalities in bone quality that are associated with hypoparathyroidism. Read More

J Clin Res Pediatr Endocrinol 2021 05 20. Epub 2021 May 20.

Umraniye Training and Research Hospital, Department of Pediatrics, Division of Neonatology, Istanbul, Turkey.

Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency (VDD), often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of VDD in LNH in Turkey and to describe the characteristics of affected newborns.

Methods: Conducted in a cross-sectional design with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Read More

Probl Endokrinol (Mosk) 2021 Feb 9;67(2):20-27. Epub 2021 Feb 9.

N.N. Blokhin National Medical Research Center of Oncology.

The exponential rise in the use of immune checkpoint inhibitors (Ipilimumab, Nivolumab, Pembrolizumab, Atezolizumab, Durvalumab, and Avelumab) as the new standard for cancer treatment increase the incidence the immune-related adverse events due to immune activation. Endocrine immune-related adverse events are the third most commonly reported. Thyroid gland is most susceptible to autoimmune dysfunctions from immune checkpoint inhibitors and associated with the use of anti-PD-1 monoclonal antibodies. Read More

J Endocrinol Invest 2021 May 18. Epub 2021 May 18.

FIRS Laboratories RSR Ltd, Cardiff, UK.

Background: Autoimmune Polyglandular Syndrome type 1 (APS-1) is a rare recessive inherited disease, caused by AutoImmune Regulator (AIRE) gene mutations and characterized by three major manifestations: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism (CH) and Addison's disease (AD).

Methods: Autoimmune conditions and associated autoantibodies (Abs) were analyzed in 158 Italian patients (103 females and 55 males; F/M 1.9/1) at the onset and during a follow-up of 23. Read More

J Clin Immunol 2021 May 18. Epub 2021 May 18.

Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.

Background: Children with complete DiGeorge anomaly (cDGA) have congenital athymia plus a myriad of other challenging clinical conditions. The term cDGA encompasses children with congenital athymia secondary to 22q11.2DS, CHARGE syndrome (coloboma, heart defects, choanal atresia, growth or mental retardation, genital abnormalities, and ear abnormalities and/or deafness), and other genetic abnormalities. Read More

Biomed Opt Express 2021 Apr 10;12(4):1999-2014. Epub 2021 Mar 10.

School of Optics and Photonics, Beijing Institute of Technology, 100081 Beijing, China.

The identification and preservation of parathyroid glands (PGs) is a major issue in thyroidectomy. The PG is particularly difficult to distinguish from the surrounding tissues. Accidental damage or removal of the PG may result in temporary or permanent postoperative hypoparathyroidism and hypocalcemia. Read More

Front Endocrinol (Lausanne) 2021 30;12:657991. Epub 2021 Apr 30.

Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Background: Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels. We aimed to describe the combined effects of 25-hydroxy vitamin D (25(OH)D), glomerular filtration rate (GFR) and age on serum PTH levels across the whole clinical spectrum.

Methods: We retrieved from our endocrinology center database all PTH measurement between 2012 and 2020 for which a simultaneous measurement of serum 25(OH)D, calcium and creatinine was available. Read More

Contrast Media Mol Imaging 2021 26;2021:6652315. Epub 2021 Apr 26.

Department of General Surgery, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang, China.

Purpose: The purpose of this study was to find the clinical significance and methods of using CN in endoscopic treatment for PTC.

Materials And Methods: A total of 108 cases were randomly enrolled and divided into two groups, with 50 cases in the CN injection group who were injected with CN and 58 cases in the control group with no CN injection. All cases were analyzed with the size of carcinoma, the number of lymph node, and parathyroid gland injury. Read More

Mol Cell Endocrinol 2021 Jul 11;531:111311. Epub 2021 May 11.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Via Lamarmora 5, 20122, Milan, Italy. Electronic address:

Parathyroid hormone (PTH), which is primarily regulated by extracellular calcium changes, controls calcium and phosphate homeostasis. Different diseases are derived from PTH deficiency (hypoparathyroidism), excess (hyperparathyroidism) and resistance (pseudohypoparathyroidism, PHP). Pseudohypoparathyroidism was historically classified into subtypes according to the presence or not of inherited PTH resistance associated or not with features of Albright's hereditary osteodystrophy and deep and progressive ectopic ossifications. Read More

Eur J Case Rep Intern Med 2021 9;8(4):002411. Epub 2021 Apr 9.

Department of Internal Medicine, Reinier de Graaf Gasthuis, Delft, The Netherlands.

22q11.2 deletion syndrome typically presents with congenital cardiac anomalies, immunodeficiencies and hypoparathyroidism. However, clinical findings vary greatly. Read More

Mov Disord Clin Pract 2021 May 3;8(4):600-603. Epub 2021 Apr 3.

Center for Parkinson's Disease and Movement Disorders Clinic Vikram Hospitals Bangalore India.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Endocrinology and Metabolism, Dokkyo Medical University, Tochigi 321-0293, Japan.

Chromosome 22q11.2 deletion syndrome is a multisystem genetic disorder that presents with hypocalcemia due to congenital hypoparathyroidism; cardiovascular, renal, and facial anomalies; and skeletal defects. This syndrome is also associated with an increased risk of autoimmune disease. Read More

JBMR Plus 2021 May 6;5(5):e10441. Epub 2021 May 6.

Endocrine Unit, Department of Medicine Massachusetts General Hospital, Harvard Medical School Boston MA USA.

Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), and long-acting PTH (LA-PTH) show distinct biologic effects with respect to skeletal and mineral metabolism endpoints, the mechanistic basis for these clinically-important differences remains incompletely understood. Previous work has revealed that differential signaling kinetics and receptor conformation engagement between different PTH1R peptide ligands. Read More

PLoS Med 2021 May 10;18(5):e1003603. Epub 2021 May 10.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Increased risk of miscarriage has been reported for women with specific chronic health conditions. A broader investigation of chronic diseases and miscarriage risk may uncover patterns across categories of illness. The objective of this study was to study the risk of miscarriage according to various preexisting chronic diseases. Read More