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Endocr J 2022 Jun 25. Epub 2022 Jun 25.

Diagnostic Pathology, Kuma Hospital, Kobe 650-0011, Japan.

Hypoparathyroidism is a major complication of thyroid surgery. To avoid this complication, visual identification of the parathyroid glands is essential. However, its effectiveness depends heavily on the surgeon's expertise. Read More

J Endocrinol Invest 2022 Jun 25. Epub 2022 Jun 25.

University Hospital of Pisa, Endocrine Unit 2, Pisa, Italy.

Purpose: Hypoparathyroidism (HypoPT) is a rare endocrine disease and conventional therapy is based on calcium and vitamin D analogues. Conventional therapy does not restore calcium homeostasis and patients complain with neuropsychological symptoms, which have been evaluated with nonspecific self-administered questionnaires. This study aims to evaluate cognitive functions of patients with chronic post-surgical (PS)-HypoPT compared to a control population, using a standardized neuropsychological approach and evaluating the relationship with serum calcium (Alb-Ca). Read More

Scand J Surg 2022 Apr-Jun;111(2):14574969221107282

Erasmus MC Cancer Institute Department of Surgical Oncology and Gastrointestinal Surgery P.O. 2040 Rotterdam 3000 The Netherlands.

Background And Objective: The reported incidence of persistent hypoparathyroidism varies widely, and consensus on a definition is lacking. The objective was to evaluate the real-life incidence of persistent hypoparathyroidism by investigating a new pragmatic definition.

Methods: This retrospective multicenter cohort study evaluated the effect of different definitions for persistent hypoparathyroidism on the incidence of hypoparathyroidism. Read More

Thyroid 2022 Jun 23. Epub 2022 Jun 23.

University Hospital Munster, 39069, Department of Nuclear Medicine, Munster, Nordrhein-Westfalen, Germany;

Background: Despite an excellent survival rate, impairments are recognized in quality of life and emotional wellbeing of differentiated thyroid cancer (DTC) survivors. Predictors for anxiety and depression in DTC patients are not well characterized.

Objective: To identify predictors for anxiety and depression in DTC survivors. Read More

Surg Endosc 2022 Jun 22. Epub 2022 Jun 22.

Department of Minimally Invasive Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, 510120, People's Republic of China.

Background: Recent years there have been witnessed considerable advances in endoscopic selective lateral neck dissection (LND). However, dissection of lymph nodes at level IV and level VI via the chest approach is inherently challenging. In this study, we used combined trans-oral and chest approach for endoscopic thyroidectomy in patients with cT1-2N1bM0 papillary thyroid carcinoma (PTC). Read More

N Z Med J 2022 Feb 4;135(1549):43-49. Epub 2022 Feb 4.

FRACS, Breast, Endocrine, Laparoscopic and Melanoma Surgeon, Department of General Surgery, Waitematā DHB, Auckland.

Aim: To describe indications and outcomes of total thyroidectomy for Graves' disease in a large New Zealand endocrine surgery unit, and to compare these results to international studies.

Methods: We analysed a prospectively collected database to describe the indications and outcomes of surgery for Graves' disease between December 2001 and January 2021.

Results: Among 64 patients who underwent total thyroidectomy at our tertiary centre for Graves' hyperthyroidism, Graves' ophthalmopathy and patient preference/aversion to radioactive iodine were the most common indications for surgery. Read More

Horm Res Paediatr 2022 Jun 20. Epub 2022 Jun 20.

Introduction: Transient or permanent hypoparathyroidism is one of the most well-known complications of total thyroidectomy and may lead to symptomatic hypocalcaemia. In children treatment of post-thyroidectomy hypocalcaemia usually consists of postoperative calcium and/or vitamin D supplementation. In 2013 we implemented prophylactic pre-thyroidectomy calcitriol supplementation for all children undergoing total thyroidectomy at the Amsterdam UMC. Read More

Sci Rep 2022 Jun 17;12(1):10211. Epub 2022 Jun 17.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Autosomal dominant mutations in FAM111A are causative for Kenny-Caffey syndrome type 2. Patients with Kenny-Caffey syndrome suffer from severe growth retardation, skeletal dysplasia, hypoparathyroidism, hypocalcaemia, hyperphosphataemia and hypomagnesaemia. While recent studies have reported FAM111A to function in antiviral response and DNA replication, its role in regulating electrolyte homeostasis remains unknown. Read More

Adv Ther 2022 Jun 11. Epub 2022 Jun 11.

Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.

Introduction: Patients with chronic hypoparathyroidism are at increased risk of cardiovascular disease. This study evaluated the risk of developing cardiovascular conditions over a period of 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1-84), rhPTH(1-84), compared with a historical control cohort of patients not treated with rhPTH(1-84).

Methods: This retrospective cohort study comprised patients with chronic hypoparathyroidism treated with rhPTH(1-84) in the REPLACE (NCT00732615), RELAY (NCT01268098), and RACE (NCT01297309) clinical trials, and controls selected from the IBM Explorys electronic medical record database (January 2007-August 2019) who did not receive parathyroid hormone but who had enrollment criteria similar to those for the clinical trials. Read More

Autoimmun Rev 2022 Jun 9;21(8):103135. Epub 2022 Jun 9.

Semey Medical University, Semey, Kazakhstan; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan.

Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive hereditary pathology that develops with endocrine and non-endocrine manifestations in childhood. The classic triad of APS-1 includes chronic candidiasis of the skin and mucous membranes, adrenal insufficiency, and hypoparathyroidism. APS-1 is often accompanied by hypogonadism, type 1 diabetes, autoimmune thyroiditis, vitiligo, alopecia, asplenia, pneumonitis, gastritis, pernicious anemia, and intestinal dysfunction, nephritis, and hepatitis. Read More

Front Endocrinol (Lausanne) 2022 24;13:850235. Epub 2022 May 24.

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Thyroidectomy for massive goiters is challenging because of the increased risk of tracheomalacia, combined sternotomy, postoperative morbidity, and mortality, whereas studies investigating the clinicopathologic characteristics, postoperative morbidities, and surgical outcomes of massive goiters are limited.

Methods: Patients with goiters undergoing thyroid surgery between 2009 and 2019 were retrospectively reviewed. A total of 227 patients were enrolled and divided into massive goiter group and large goiter group according to the weight of the goiter. Read More

J Clin Med 2022 Jun 3;11(11). Epub 2022 Jun 3.

Department of Endocrine Surgery, Endocrine Center Stuttgart, Diakonie-Klinikum Stuttgart, 70176 Stuttgart, Germany.

Background: Postsurgical hypoparathyroidism (PH) is the most common side effect of bilateral thyroid resections. Data regarding the time course of recovery from PH are currently unavailable. Therefore, a detailed analysis of the time course of PH recovery and conditions associated with rapid recovery was conducted. Read More

J Clin Med 2022 Jun 1;11(11). Epub 2022 Jun 1.

Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.

Growing evidence shows that arterial stiffness measurement provides important prognostic information and improves clinical stratification of cardiovascular risk. Thyroid and parathyroid diseases are endocrine diseases with a relevant cardiovascular burden. The objective of this review was to consider the relationship between arterial stiffness and thyroid and parathyroid diseases in human clinical studies. Read More

Methods Mol Biol 2022 ;2534:57-78

Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Cervical lymph node metastasis is frequent in patients with papillary thyroid carcinoma. In addition to the extent of thyroidectomy, the need as well as the extent of concomitant lymphadenectomy has been a subject of controversy and debate. The central compartment is the most frequent site of metastasis followed by the lateral compartment although skip metastasis in the lateral compartment can occur. Read More

Exp Biol Med (Maywood) 2022 Jun 6:15353702221097087. Epub 2022 Jun 6.

Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Delivering the parathyroid hormone (PTH) gene has been attempted preclinically in a handful of studies, but delivering full-length PTH (1-84) using adeno-associated viral (AAV) vectors has not. Given the difficulty in achieving therapeutic levels of secreted proteins using gene therapy, this study seeks to determine the feasibility of doing so with PTH. An AAV vector was used to deliver human PTH driven by a strong promoter. Read More

Cureus 2022 Apr 27;14(4):e24521. Epub 2022 Apr 27.

Endocrinology, State University of New York Downstate Medical Center, Brooklyn, USA.

Unlike hyperparathyroidism, hypoparathyroidism is rarely encountered in clinical practice. Usually, it results from surgical resection, an autoimmune phenomenon, or an infiltrative process. Under certain circumstances, one may encounter a genetic etiology of hypoparathyroidism, often combined with myriad other syndromic manifestations. Read More

J Bone Miner Metab 2022 May 31. Epub 2022 May 31.

Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Introduction: Despite the high prevalence of hypocalcemia in patients with COVID-19, very limited studies have been designed to evaluate etiologies of this disorder. This study was designed to evaluate the status of serum parameters involved in calcium metabolism in patients with COVID-19 and hypocalcemia.

Materials And Methods: This cross-sectional study was conducted on 123 hospitalized patients with COVID-19. Read More

Ann Med Surg (Lond) 2022 May 5;77:103572. Epub 2022 Apr 5.

College of Medicine, University of Sulaimani, Sulaimani, Kurdistan, Iraq.

Introduction: In both pediatric and adult populations, hypocalcemia-induced heart failure is an extremely rare presentation. The aim of the current study is to report a case of reversible heart failure caused by severe hypocalcemia resulting from hypoparathyroidism, which was resolved by correcting the serum calcium level.

Case Report: A 29-year-old female presented with orthopnea, dyspnea on mild exertion, and bilateral lower limb swelling. Read More

BMJ Case Rep 2022 May 20;15(5). Epub 2022 May 20.

Diabetes & Endocrinology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Genetic causes of hypocalcaemia can be overlooked in patients who present without apparent syndromic features. One relatively common but under-recognised genetic disorder is DiGeorge syndrome, which is often diagnosed in childhood but rarely in adulthood. Its enigmatic diagnosis can be attributed to its broad heterogeneous clinical presentation, such as the absence of cardiac abnormalities with only subtly abnormal facies. Read More

Int Arch Otorhinolaryngol 2022 Apr 23;26(2):e219-e225. Epub 2021 Aug 23.

Department of Surgery, Shalamar Medical and Dental College, Lahore, Pakistan.

 Total thyroidectomy remains highly technical, with a significant risk of recurrent laryngeal nerve (RLN) compromise and hypoparathyroidism. After identifying RLN, at the level of the ligament of Berry, local factors may compel the surgeon to either dissect along the nerve or the thyroid capsule.  The objective of the present study is to compare these two approaches in terms of outcomes and complication rates. Read More

J Taibah Univ Med Sci 2022 Apr 28;17(2):214-219. Epub 2021 Aug 28.

National & Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, 2nd Otolaryngology Department, Athens, Greece.

Objectives: Hypocalcaemia and hypoparathyroidism are the most frequent complications of total thyroidectomy that may result in the need for lifelong calcium supplementation. This study aims to investigate the impact of incidental parathyroidectomy on short- and long-term hypocalcaemia.

Methods: This retrospective study was conducted on patients who underwent total thyroidectomy with or without central neck dissection between March 2016 to May 2018. Read More

J Endocrinol Invest 2022 May 19. Epub 2022 May 19.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, 110029, India.

Purpose: Patients with hypoparathyroidism are at risk of vertebral fractures (VFs) despite high bone mineral density (BMD). We investigated this paradox by assessing trabecular bone score (TBS) and hip structural analysis (HSA) in non-surgical chronic hypoparathyroidism (cHypoPT) with and without VFs.

Methods: 152 cHypoPT patients (age 40. Read More

Endocr Connect 2022 May 1. Epub 2022 May 1.

D Lourenço Junior, Endocrine Genetics Unit (LIM-25), Endocrinology Division (Hospital das Clinicas) and Endocrine Oncology Division, Institute of Cancer of the State of São Paulo (ICESP), Universidade de São Paulo Hospital das Clínicas, Sao Paulo, Brazil.

Background: Potential influences of the parathyroidectomy (PTx) on quality of life (QoL) in multiple endocrine neoplasia type 1-related primary hyperparathyroidism (HPT/MEN1) are unknown.

Method: Short Form 36 Health Survey Questionnaire was prospectively applied in 30 HPT/MEN1 patients submitted to PTx (20, subtotal; 10, total with autograft), before, 6 and 12 months (mo.) after surgery. Read More

Forensic Sci Int 2022 Jul 2;336:111323. Epub 2022 May 2.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China; Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

Thymic hypoplasia is a primary cellular immunodeficiency that causes susceptibility to serious infections leading to sudden death in infants. Some genetic disorders in humans could result in the evident permanent hypoplasia or occasional aplasia of the thymus at birth. However, determining the genetic etiology of thymic hypoplasia is challenging for the sudden infant death due to primary cellular immunodeficiency. Read More

Cogn Res Princ Implic 2022 05 15;7(1):45. Epub 2022 May 15.

Experimental Psychology, Justus Liebig University, Giessen, Germany.

During the COVID-19 pandemic, the wearing of face masks became mandatory in public areas or at workplaces in many countries. While offering protection, the coverage of large parts of our face (nose, mouth and chin) may have consequences for face recognition. This seems especially important in the context of contact tracing which can require memory of familiar and unfamiliar contacts and whether they were wearing a mask. Read More

Nutrients 2022 Apr 26;14(9). Epub 2022 Apr 26.

Center of Excellence of Bariatric Surgery of the Italian Society of Obesity Surgery and Metabolic Disease (SICOB), Unit of General and Emergency Surgery, University Hospital San Giovanni di Dio e Ruggid'Aragona, P.O. Gaetano FucitoMercato San Severino, 84085 Salerno, Italy.

Background: Hypoparathyroidism-related hypocalcemia is a common complication after total thyroidectomy (TT), particularly if there is a history of prior bariatric surgery. However, it is still unknown if it is the surgery timing or the type of bariatric intervention that increases the risk of developing this complication.

Methods: We compared the risk of hypocalcemia (serum calcium levels < 8 mg/dL) and hypoparathyroidism (both transient and permanent) between patients with restrictive procedures (LSG and GB) and patients without a history of obesity surgery in the immediate post-operative period and after 12 months. Read More

Endocr Rev 2022 05;43(3):583-609

Department of Diabetes and Endocrinology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Mitochondrial diseases are a group of common inherited diseases causing disruption of oxidative phosphorylation. Some patients with mitochondrial disease have endocrine manifestations, with diabetes mellitus being predominant but also include hypogonadism, hypoadrenalism, and hypoparathyroidism. There have been major developments in mitochondrial disease over the past decade that have major implications for all patients. Read More

Arch Endocrinol Metab 2022 May 12. Epub 2022 May 12.

Istanbul University, Istanbul Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey.

Dilated cardiomyopathy (DCM) is characterized by systolic dysfunction and is usually idiopathic. A rare cause of reversible DCM is hypocalcemia. Calcium plays a key role in myocardial contraction. Read More

BJS Open 2022 05;6(3)

Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland.

CMAJ 2022 May;194(18):E661-E662

Département de médecine, Université de Toronto, Toronto, Ont.