Search our Database of Scientific Publications and Authors

I’m looking for a

    7890 results match your criteria Hypoparathyroidism

    1 OF 158

    Association of Otolaryngology Resident Duty Hour Restrictions With Procedure-Specific Outcomes in Head and Neck Endocrine Surgery.
    JAMA Otolaryngol Head Neck Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Otolaryngology-Head & Neck Surgery, University of Tennessee Health Science Center, Memphis.
    Importance: Graduate medical education has undergone a transformation from traditional long work hours to a restricted plan to allow adequate rest for residents. The initial goal of this restriction is to improve patient outcomes.

    Objective: To determine whether duty hour restrictions had any impact on surgery-specific outcomes by analyzing complications following thyroid and parathyroid procedures performed before and after duty hour reform. Read More

    Perioperative determinants of transient hypocalcemia after pediatric total thyroidectomy.
    J Pediatr Surg 2017 Jan 27. Epub 2017 Jan 27.
    Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital and Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030. Electronic address:
    Purpose: We seek to identify risk factors associated with hypocalcemia after pediatric total thyroidectomy.

    Methods: We retrospectively reviewed patients younger than 21years undergoing total thyroidectomy between January 2002 and January 2016. We defined hypocalcemia as any serum calcium <8mg/dl or ionized calcium <1. Read More

    The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical Hypoparathyroidism-Related Hypocalcemia Refractory to Supplemental Therapy with High Doses of Oral Calcium.
    Front Endocrinol (Lausanne) 2017 26;8. Epub 2017 Jan 26.
    Biomedical Department of Internal and Specialist Medicine (DIBIMIS), Section of Endocrine-Metabolic Diseases, University of Palermo , Palermo , Italy.
    The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia. The aim of the study is to evaluate the biochemical mechanisms inducing hypocalcemia in a female patient with usual high consumption of cola drink and persistent hypocalcemia, who failed to respond to high doses of calcium and calcitriol supplementation. At baseline and after pentagastrin injection, gastric secretion (Gs) and duodenal secretion (Ds) samples were collected and calcium and total phosphorus (Ptot) concentrations were evaluated. Read More

    Site-Specific Difference of Bone Geometry Indices in Hypoparathyroid Patients.
    Endocrinol Metab (Seoul) 2017 Feb 8. Epub 2017 Feb 8.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Background: Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA). Read More

    Parathyroid reimplantation with PR-FaST technique in unselected patients during thyroidectomy. A case series with long term follow up confirming graft vitality and parathormone production.
    Int J Surg 2017 Feb 3;39:202-205. Epub 2017 Feb 3.
    Department of Surgery "P. Valdoni", Sapienza University, Rome, Italy.
    Introduction: Parathyroid damage or unintentional excision still affect thyroid surgery and may cause permanent hypoparathyroidism. The only way to recover the excised or ischemic gland functionality is still reimplantation. Many sites of reimplantation have been described, each of one showing both advantages and drawbacks. Read More

    Surgical safety analysis of retaining the glands in papillary thyroid microcarcinoma.
    Eur Rev Med Pharmacol Sci 2017 Jan;21(2):234-238
    The Third General Surgery, The Central Hospital of Zhumadian City, Zhumadian City, China.
    Objective: The objective of the present study was to analyze the surgical safety of retaining the glands in papillary thyroid microcarcinoma (mPTC).

    Patients And Methods: 156 cases of mPTC were retrospectively reviewed and divided into four groups according to the treatment: group A (conservative follow-up group, 30 cases), group B (total resection of unilateral gland combined with isthmic resection, 48 cases), group C (total resection of unilateral gland combined with subtotal resection of contralateral gland, 47 cases), and group D (total resection of bilateral glands, 31 cases). The average follow-up time was 34. Read More

    Afebrile Seizures as Initial Symptom of Hypocalcemia Secondary to Hypoparathyroidism.
    J Neurosci Rural Pract 2016 Dec;7(Suppl 1):S117-S119
    Department of Pediatric, General Hospital of Veroia, Pediatric Clinic, Veroia, Greece.
    Hypocalcemia is rare in childhood and caused, among other conditions, by hypoparathyroidism. DiGeorge syndrome is the most common cause of hypoparathyroidism in childhood. Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. Read More

    Status Dystonicus in a Child with Familial Idiopathic Hypoparathyroidism.
    Indian J Pediatr 2017 Feb 4. Epub 2017 Feb 4.
    Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
    Hypoparathyroidism leading to status dystonicus is rarely reported in literature. The authors present an 8-y-old girl with idiopathic familial hypoparathyroidism who presented with status dystonicus. She was managed successfully with midazolam infusion, calcium and vitamin D supplementation, and oral anti-dystonia drugs. Read More

    Early Predictors of Post - Thyroidectomy Hypoparathyroidism.
    Pol Przegl Chir 2016 Dec;88(6):305-314
    Thyroid surgery is the most commonly performed procedure in the field of endocrine surgery. Studies are still ongoing on the development of a single algorithm for diagnosis and care of patients at risk of postoperative hypoparathyroidism. The aim of the study was to determine the biochemical marker that would allow the most accurate diagnosis of patient groups at risk of developing hypoparathyroidism and to identify risk factors for this disorder. Read More

    Short stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene.
    Int J Pediatr Endocrinol 2017 25;2017. Epub 2017 Jan 25.
    0000 0004 0625 8600grid.410667.2Department of Endocrinology, Princess Margaret Hospital, Perth, Australia ; 0000 0004 1936 7910grid.1012.2School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia ; 0000 0004 0625 8600grid.410667.2Department of Endocrinology and Diabetes, Princess Margaret Hospital, Perth, Australia.
    Background: Hypoparathyroidism in children is a heterogeneous group with diverse genetic etiologies. To aid clinicians in the investigation and management of children with hypoparathyroidism, we describe the phenotype of a 6-year-old child with hypoparathyroidism and short stature diagnosed with Kenny-Caffey syndrome (KCS) Type 2 and the subsequent response to growth hormone (GH) treatment.

    Case Presentation: The proband presented in the neonatal period with hypocalcemic seizures secondary to hypoparathyroidism. Read More

    Review of Hypoparathyroidism.
    Front Endocrinol (Lausanne) 2016 16;7:172. Epub 2017 Jan 16.
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic , Rochester, MN , USA.
    Hypoparathyroidism is a rare endocrine disorder in which parathyroid hormone (PTH) production is abnormally low or absent, resulting in low serum calcium and increased serum phosphorus. The most common cause of hypoparathyroidism is parathyroid gland injury or inadvertent removal during thyroid surgery. Current treatments include supplementation with calcium and active vitamin D, with goal albumin-corrected serum calcium level in the low-normal range of 8-9 mg/dl. Read More

    Postoperative hypomagnesaemia is not associated with hypocalcemia in thyroid cancer patients undergoing total thyroidectomy plus central compartment neck dissection.
    Int J Surg 2017 Jan 24;39:192-196. Epub 2017 Jan 24.
    Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
    Background: The literature remains scarce and controversial regarding the association of hypomagnesaemia and hypocalcemia after total thyroidectomy. This study aims to assess this association in thyroid cancer patients underwent total thyroidectomy (TT) plus central compartment neck dissection (CCND).

    Method: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and June 2016 in a tertiary referral hospital. Read More

    Applying criteria of active surveillance to low-risk thyroid papillary cancer over a decade: How many surgeries and complications can be avoided?
    Thyroid 2017 Jan 26. Epub 2017 Jan 26.
    Duke, Radiology , Box 3808 , Durham, North Carolina, United States , 27710 ;
    Background: The 2015 American Thyroid Association guidelines acknowledged that "an active surveillance management approach can be considered as an alternative to immediate surgery" in patients with low risk papillary thyroid carcinoma (PTC). The aim of this study is to determine the proportion of PTC that would meet criteria for active surveillance and the surgeries and complications that could have been avoided.

    Methods: We retrospectively reviewed 681 patients with thyroid cancer who underwent thyroid surgery from 2003 to 2012. Read More

    Diseases associated with calcium-sensing receptor.
    Orphanet J Rare Dis 2017 Jan 25;12(1):19. Epub 2017 Jan 25.
    Service d'Endocrinologie et Métabolisme, Hôpital C Huriez Centre Hospitalo-universitaire de Lille, 1 rue Polonovski, 59 037, Lille Cedex, France.
    The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The diseases caused by an abnormality of the CaSR are genetically determined or are more rarely acquired. The genetic diseases consist of hyper- or hypocalcemia disorders. Read More

    Incidental parathyroidectomy during thyroidectomy increases the risk of postoperative hypocalcemia.
    Laryngoscope 2017 Jan 25. Epub 2017 Jan 25.
    Department of Surgery, Chang Gung Memorial Hospital Linkou Branch, Chang Gung University, Taoyuan, Taiwan.
    Objectives/hypothesis: The correlation between incidental parathyroidectomy (IP) during thyroidectomy and postoperative hypocalcemia remains controversial. Our aim was to investigate the incidence of IP, risk factors, and impact on patient outcomes.

    Study Design: Retrospective cohort study. Read More

    Applicability of rapid intraoperative parathyroid hormone assay through fine needle aspiration to identify parathyroid tissue in thyroid surgery.
    Exp Ther Med 2016 Dec 14;12(6):4072-4076. Epub 2016 Nov 14.
    Jilin Provincial Key Laboratory of Surgical Translational Medicine, Divison of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
    Hypoparathyroidism is a frequent and serious complication of thyroid surgery. Identification and preservation of the parathyroid glands are key factors in managing hypoparathyroidism. The aim of the present study was to investigate the efficacy of rapid intraoperative parathyroid hormone (rIO-PTH) assay levels through fine needle aspiration (FNA) in identifying parathyroids as a parameter in thyroid surgery. Read More

    Partial monosomy of 10p and duplication of another chromosome in two patients.
    Pediatr Int 2017 Jan;59(1):99-102
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    Partial monosomy of 10p is a rare chromosomal abnormality. Common features are hypoparathyroidism, deafness, renal anomalies, distinctive facies, and mental retardation, with phenotypic variability. We report two patients with chromosomal abnormalities identified on single-nucleotide polymorphism (SNP) array analysis. Read More

    Complications of Bilateral Neck Dissection in Thyroid Cancer From a Single High-Volume Center.
    JAMA Otolaryngol Head Neck Surg 2017 Jan 12. Epub 2017 Jan 12.
    Department of Otolaryngology-Head & Neck Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Importance: The morbidity of bilateral lateral neck dissection (BLND) for thyroid cancers has not been described in detail. This study delineates the specific complications arising from BLND for thyroid cancers at a single high-volume center.

    Objective: To determine the morbidity associated with BLNDs for differentiated thyroid cancers at our institution. Read More

    Autoimmune thyroiditis associated with Sanjad-Sakati syndrome: A call for regular thyroid screening.
    Sudan J Paediatr 2016 ;16(2):41-44
    Department of pediatrics, College of Medicine , King Khalid University Hospital, King Saud University, Riyadh , Saudi Arabia.
    Sanjad-Sakati Syndrome (SSS) is a rare autosomal recessive disorder characterized by congenital hypoparathyroidism, growth retardation and dysmorphism. Thyroid status of patients with SSS has not been widely explored. Therefore, we aimed to review the occurrence of autoimmune thyroiditis, which is commonly associated with other genetic disorders, in SSS. Read More

    A comparison of lobectomy and total thyroidectomy in patients with papillary thyroid microcarcinoma: a retrospective individual risk factor-matched cohort study.
    Eur J Endocrinol 2017 Apr 15;176(4):371-378. Epub 2017 Jan 15.
    Departments of Internal Medicine
    Objective: Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients.

    Design And Methods: In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Read More

    Failure of fragmented parathyroid gland autotransplantation to prevent permanent hypoparathyroidism after total thyroidectomy.
    Langenbecks Arch Surg 2017 Jan 7. Epub 2017 Jan 7.
    Endocrine Surgery Unit, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain.
    Purpose: Parathyroid autotransplantation during total thyroidectomy leads to higher rates of postoperative hypocalcaemia. It has been argued, however, that it prevents permanent hypoparathyroidism. The impact of autografted normal parathyroid gland fragments on long-term parathyroid status has not been assessed properly. Read More

    [Clinical characteristics of adult-onset primary hypoparathyroidism: a retrospective analysis of 200 cases].
    Zhonghua Nei Ke Za Zhi 2017 Jan;56(1):19-23
    Key Laboratory of Endocrinology of National Health And Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To study the clinical characteristics of primary hypoparathyroidism in adults. Methods: The clinical data of 200 cases with adult-onset primary hypoparathyroidism in Peking Union Medical College Hospital during December 1987 to December 2015 were collected and analyzed retrospectively. Among them, 128 cases were followed up for a median period of 3 years. Read More

    The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation.
    Sci Rep 2017 Jan 4;7:39856. Epub 2017 Jan 4.
    Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
    Differentiated neurons and glia are acquired from immature precursors via transcriptional controls exerted by factors such as proteins in the family of Glial Cells Missing (Gcm). Mammalian Gcm proteins mediate neural stem cell induction, placenta and parathyroid development, whereas Drosophila Gcm proteins act as a key switch to determine neuronal and glial cell fates and regulate hemocyte development. The present study reports a hypoparathyroidism-associated mutation R59L that alters Drosophila Gcm (Gcm) protein stability, rendering it unstable, and hyperubiquitinated via the ubiquitin-proteasome system (UPS). Read More

    A prospective cohort study of novel functional types of parathyroid glands in thyroidectomy: In situ preservation or auto-transplantation?
    Medicine (Baltimore) 2016 Dec;95(52):e5810
    Department of Thyroid and Breast Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China.
    The best method of preventing hypoparathyroidism after thyroidectomy is to keep parathyroid glands in situ. However, hypoparathyroidism still regularly occurs with the existing parathyroid classification system, and the incidence of permanent hypoparathyroidism has not been reduced. We created a novel system for classifying parathyroid glands that can guide parathyroid preservation in thyroidectomy. Read More

    A Quick Reference on Hypocalcemia.
    Vet Clin North Am Small Anim Pract 2017 Mar 22;47(2):249-256. Epub 2016 Dec 22.
    The Ohio State University, 317 West 6th Avenue, Columbus, OH 43201, USA. Electronic address:
    Primary hypoparathyroidism should be considered in dogs with vague signs, including tremors, facial rubbing, and seizures. Ionized hypocalcemia should be considered in dogs with protein-losing enteropathy, especially lymphangiectasia caused by hypovitaminosis D. Ionized hypocalcemia typically occurs only in advanced chronic kidney disease. Read More

    The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study.
    Calcif Tissue Int 2017 Mar 24;100(3):278-285. Epub 2016 Dec 24.
    Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
    Hypoparathyroidism is a rare endocrine disorder, but few studies have focused on the epidemiology and hospital management of the disease and none has been performed in Italy. We investigated the prevalence of different forms of hypoparathyroidism among hospitalized patients in Italy during an 8-year period. This study is designed as a retrospective register-based study. Read More

    Application of carbon nanoparticles accelerates the rapid recovery of parathyroid function during thyroid carcinoma surgery with central lymph node dissection: A retrospective cohort study.
    Int J Surg 2016 Oct 27. Epub 2016 Oct 27.
    Department of General Surgery, Changzheng Hospital affiliated to The Second Military Medical University, Shanghai 200003, China. Electronic address:
    Background And Objectives: The aim of this study was to evaluate the efficacy of carbon nanoparticles in identifying lymph nodes and promoting parathyroid gland function recovery after thyroid carcinoma surgery along with central lymph node dissection.

    Methods: A total of 231 patients who underwent thyroid carcinoma surgery combined with central lymph node dissection were divided into two groups: the CN group (intraoperative carbon nanoparticles injections) and the control group (no injection). Datas were collected respectively on the pre-operative, 1(st), 7(th) and 30(th) postoperative days and monthly thereafter. Read More

    The deceptive concept of hypoparathyroidism and recurrence after parathyroidectomy in dialysis patients: are we offering a Procrustean bed to some patients?
    Rev Col Bras Cir 2016 Sep-Oct;43(5):327-333
    Department of Internal Medicine, Faculty of Medicine, University of Sao Paulo, São Paulo, SP, Brazil.
    Objective:: to analyze the frequency of hypoparathyroidism and of its recurrence after parathyroidectomy in dialysis patients according to different existing classifications.

    Methods:: we conducted a retrospective study of 107 consecutive dialysis patients undergoing total parathyroidectomy with immediate autograft in a tertiary hospital from 2006 to 2010. We studied the changes in PTH levels in the postoperative period over time. Read More

    Computed tomography anomalies associated with isolated hypoparathyroidism.
    Clin Case Rep 2016 Dec 15;4(12):1205-1206. Epub 2016 Oct 15.
    Department of Internal Medicine Yamatotakada Municipal Hospital Yamatotakada-Shi Nara-Ken Japan.
    Hypocalcemia due to chronic hypoparathyroidism presents with nonspecific symptoms. However, if untreated, hypocalcemia may affect neurological, cognitive, muscular, and cardiac function. Computed tomography (CT) findings may confirm a diagnosis of chronic hypoparathyroidism. Read More

    Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require antiepileptic drugs.
    Childs Nerv Syst 2016 Dec 12. Epub 2016 Dec 12.
    Department of Pediatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
    Objective: Patients with hypoparathyroidism exhibit metabolic disorders (hypocalcemia) and brain structural abnormalities (brain calcifications). Currently, studies have determined whether antiepileptic drug (AED) treatment is required for epileptic seizures in children with hypoparathyroidism.

    Method: This study aims to evaluate the data of two medical centers in Beijing based on the diagnosis of epileptic seizures as the first symptom of hypoparathyroidism in children. Read More

    Short-Term PTH(1-34) Therapy in Children to Correct Severe Hypocalcemia and Hyperphosphatemia due to Hypoparathyroidism: Two Case Studies.
    Case Rep Endocrinol 2016 13;2016:6838626. Epub 2016 Nov 13.
    Pediatric Endocrinology, University of Minnesota, Minneapolis, MN, USA.
    The standard treatment of hypoparathyroidism is to control hypocalcemia using calcitriol and calcium supplementation. However, in severe cases this approach is insufficient, and the risks of intravenous (i.v. Read More

    Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism.
    Int J Endocrinol Metab 2016 Jul 17;14(3):e38440. Epub 2016 Aug 17.
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage-Hansensgade 2, Aarhus C, Denmark.
    Background: Muscles and bones are interconnected. Recent studies suggest that undercarboxylated osteocalcin from bone may affect muscle mass and strength. There are, however, no prospective human data on this relationship. Read More

    Therapeutic Effects of Bipolar Coagulation Forceps on Open Thyroid Surgery.
    Rev Invest Clin 2016 Sep-Oct;68(5):256-261
    Department of Thyroid Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.
    Background: The aim was to compare the therapeutic effects of bipolar coagulation forceps, harmonic scalpel, and conventional thyroidectomy on open thyroid surgery.

    Methods: A total of 527 patients who received open thyroid surgery in the Affiliated Drum Tower Hospital of Nanjing University Medical School between February 2013 and February 2016 were randomly divided into three groups: bipolar coagulation forceps, harmonic scalpel, and conventional thyroidectomy. There were no statistically significant differences in gender, age, disease constituents or mass diameter between the three groups. Read More

    Brown tumor of the jaw after pregnancy and lactation in a MEN1 patient.
    Endocrinol Diabetes Metab Case Rep 2016 16;2016. Epub 2016 Nov 16.
    Department of Endocrinology.
    : Skeletal manifestations of primary hyperparathyroidism (pHPT) include brown tumors (BT), which are osteoclastic focal lesions often localized in the jaws. Brown tumors are a rare manifestation of pHTP in Europe and USA; however, they are frequent in developing countries, probably related to vitamin D deficiency and longer duration and severity of disease. In the majority of cases, the removal of the parathyroid adenoma is enough for the bone to remineralize, but other cases require surgery. Read More

    Pattern of calcium and parathyroid hormone normalization at 12-months follow-up after parathyroid operation.
    Surgery 2016 Nov 29. Epub 2016 Nov 29.
    Department of Endocrine Surgery Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH. Electronic address:
    Background: At 12 months after a parathyroid operation, we expect cured patients to have biochemical profiles similar to those of healthy individuals. The aim of the current study was to compare the biochemical characteristics patients at 12 months after parathyroidectomy for primary sporadic hyperparathyroidism with those of healthy controls.

    Methods: A total of 547 patients who underwent parathyroid neck operation for primary sporadic hyperparathyroidism from 2000-2014 were analyzed. Read More

    Early onset brain calcifications secondary to hypoparathyroidism in a boy with syncopal-like symptomatology.
    Acta Neurol Belg 2016 Dec 1. Epub 2016 Dec 1.
    Unit for severe disabilities of developmental age and young adults (Developmental Neurology and Neurorehabilitation), Scientific Institute I.R.C.C.S. "Eugenio Medea", "La Nostra Famiglia", Ex Complesso Ospedaliero "A. Di Summa"-Piazza "A. Di Summa", Brindisi Research Centre, 72100, Brindisi, Italy.

    Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications.
    Arch Endocrinol Metab 2016 Nov-Dec;60(6):532-536. Epub 2016 Nov 24.
    Serviço de Endocrinologia e Metabologia do Paraná (SEMPR), Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
    Objectives: To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities.

    Materials And Methods: Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG).

    Results: Fifty-five patients were identified, 42 females and 13 males; mean age of 44. Read More

    Intermittent neural monitoring of the recurrent laryngeal nerve in surgery for recurrent goiter.
    Gland Surg 2016 Oct;5(5):481-489
    Department of Endocrine Surgery, 3rd Chair of General Surgery, Jagiellonian University Medical College, Krakow, Poland.
    Reoperative thyroid surgery is still challenging even for skilled surgeons, and is associated with a higher incidence of complications, such as hypoparathyroidism and recurrent laryngeal nerve (RLN) palsy. Displacement of the RLN, scar tissue from previous neck surgery and difficulty in maintaining good hemostasis are risk factors in reoperations. The prevalence of RLN injury in reoperative thyroid surgery ranges as high as 12. Read More

    Can we consider immediate complications after thyroidectomy as a quality metric of operation?
    Surgery 2017 Jan 17;161(1):156-165. Epub 2016 Nov 17.
    Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Lyon, France; Assistance Publique-Hôpitaux de Paris, Hôpital la Pitié-Salpêtrière, Service de Chirurgie Générale, Viscérale et Endocrinienne, Paris, Assistance Publique-Hôpitaux de Marseille, CHU la Conception, France.
    Background: Permanent recurrent laryngeal nerve palsy and hypoparathyroidism are 2 major complications after thyroid operation. Assuming that the rate of immediate complications can predict the permanent complication rate, some authors consider these complications as a valid metric for assessing the performance of individual surgeons. This study aimed to determine the correlation between rates of immediate and permanent complications after thyroidectomy at the surgeon level. Read More

    Normohormonal primary hyperparathyroidism is a distinct form of primary hyperparathyroidism.
    Surgery 2017 Jan 17;161(1):62-69. Epub 2016 Nov 17.
    Department of Surgery, Endocrine Surgery Research Program, University of Chicago, Chicago, IL.
    Background: Normohormonal primary hyperparathyroidism presents diagnostic and intraoperative challenges, and current literature is conflicting about management. We aim to better define normohormonal primary hyperparathyroidism in order to improve the care for these patients.

    Methods: In the study, 516 consecutive patients undergoing parathyroidectomy for primary hyperparathyroidism were divided into 2 groups: classic primary hyperparathyroidism (classic primary hyperparathyroidism, increased serum levels of calcium, and parathyroid hormone) and normohormonal primary hyperparathyroidism (hypercalcemia, normal serum levels of parathyroid hormone). Read More

    Enhanced identification and functional protective role of carbon nanoparticles on parathyroid in thyroid cancer surgery: A retrospective Chinese population study.
    Medicine (Baltimore) 2016 Nov;95(46):e5148
    aThe Fourth Department of General Surgery, the Second Affiliated Hospital, Harbin Medical University, Harbin bDepartment of Oncology and Thoracic Surgery, Affiliated Hospital of Shaanxi, University of Chinese Medicine, Xiaan cDepartment of Head and Neck Surgery, the Cancer Hospital of Chinese Academy of Medical Sciences, Chaoyang District, Beijing, China.
    The aim of this study was to determine the effects of nanocarbon particles in combination with meticulous capsular dissection on enhancing the identification and protecting the function of parathyroid glands in thyroid cancer surgery.The data of 97 patients with papillary thyroid tumors diagnosed and treated at the Second Affiliated Hospital, Harbin Medical University between January 2014 and February 2015 were reviewed. Data regarding the sex, age, calcium and parathyroid hormone (PTH) levels, tumor size, multifocality, T stage, and extrathyroid invasion were collected. Read More

    Neuropsychiatric phenotype in a child with pseudohypoparathyroidism.
    J Pediatr Neurosci 2016 Jul-Sep;11(3):267-270
    Department of Pediatrics, Pediatric Endocrinology and Rare Diseases Unit, S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
    Pseudohypoparathyroidism (PHP) is a rare heterogeneous genetic disease characterized by end-organ resistance to parathyroid hormone. In adulthood, heterogeneous neurological and psychiatric disorders have been reported which are associated with hypoparathyroidism in general and with PHP in particular, while for childhood, data are scanty. We report a case of a boy with PHP type 1b, in whom neurological signs at the onset prevailed, characterized by tic-like dyskinesias associated with a series of heterogeneous not well-defined neurological and behavioral features, describing the diagnostic work-up performed and the follow-up. Read More

    Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.
    Nat Commun 2016 Nov 18;7:13384. Epub 2016 Nov 18.
    Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
    Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we show that PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. Read More

    Early prediction of post-thyroidectomy hypocalcemia by early parathyroid hormone measurement.
    Ann Ital Chir 2016 ;87:417-421
    Aim: Hypoparathyroidism is the most common complication of total thyroidectomy (TT). Postthyroidectomy hypocalcemia occurs 24 to 48 hours after the operation. It prolongs the length of hospital stay, even though transient in most cases. Read More

    Hypocalcemia after thyroidectomy in patients with a history of bariatric surgery.
    Surg Obes Relat Dis 2016 Sep 28. Epub 2016 Sep 28.
    Department of General and Endocrine Surgery, Hospital Pitié Salpêtrière, APHP, Paris, France. Electronic address:
    Background: Hypocalcemia is a common complication after total thyroidectomy. Previous bariatric surgery could be a higher factor risk for hypocalcemia due to alterations in calcium absorption and vitamin D deficiency.

    Objectives: To evaluate incidence and factors involved in the risk of hypocalcemia (transient and permanent) and the postoperative outcomes of these patients after total thyroidectomy. Read More

    Serum 1,25-dihydroxyvitamin D as a biomarker of the absence of hypercalciuria in postsurgical hypoparathyroidism.
    J Clin Endocrinol Metab 2016 Nov 4:jc20162987. Epub 2016 Nov 4.
    2 Diabetes Research and Metabolism Unit, Institut de Recerca Hospital Universitari Vall d'Hebron (VHIR), Barcelona, Spain.
    Context: Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment which can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable.

    Objective: To find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism under treatment with oral calcium and calcitriol supplements. Read More

    1 OF 158