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    CENTRAL DIABETES INSIPIDUS: CLINICAL CHARACTERISTICS AND LONG-TERM COURSE IN A LARGE COHORT OF ADULTS.
    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Reset Osmostat: The Result of Chronic Desmopressin Abuse?
    Am J Kidney Dis 2017 Feb 17. Epub 2017 Feb 17.
    Section of Nephrology, Division of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL. Electronic address:
    A reset osmostat as a cause of hyponatremia can be found in a variety of clinical settings, including pulmonary and neurologic diseases, as well as in physiologic circumstances such as pregnancy. This teaching case describes a 72-year-old white man with a long-standing history of self-medicating with desmopressin acetate (DDAVP) who presented with profound hyponatremia. On discontinuation of DDAVP treatment, he was found to have a reset osmostat. Read More

    Syndrome of inappropriate antidiuretic hormone secretion following irinotecan-cisplatin administration as a treatment for recurrent ovarian clear cell carcinoma.
    Obstet Gynecol Sci 2017 Jan 19;60(1):115-117. Epub 2017 Jan 19.
    Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
    Syndrome of inappropriate antidiuretic hormone secretion (SIADH) has various causes including central nervous system disorders, pulmonary and endocrine diseases, paraneoplastic syndromes, and use of certain drugs. SIADH induced by chemotherapy with irinotecan-cisplatin is not a common complication. Here, we review a case of SIADH after treatment with irinotecan-cisplatin. Read More

    Demographical and clinicopathological characteristics in heart failure and outcome predictors: a prospective, observational study.
    ESC Heart Fail 2017 Feb 7;4(1):16-22. Epub 2016 Oct 7.
    Department of Cardiology Government Medical College Calicut India.
    Aims: The aims of the study were to study the demographical and clinicopathological characteristics of patients presenting with heart failure and evaluate the 1 year outcomes and to identify risk predictors if any.

    Methods And Results: A prospective observational study was conducted in consecutive patients of systolic heart failure. The study was divided into two parts-an initial 6 month enrolment phase followed up for 1 year for major adverse cardiovascular events. Read More

    Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on (18)F-FDG PET/CT.
    World J Nucl Med 2017 Jan-Mar;16(1):56-58
    Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Denmark.
    Case report describing the finding of central pontine myelinolysis (CPM) using combined fluorine-18 ( (18)F)-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The patient was a known alcoholic who, during admission was under treatment for hyponatremia, showed a significant decline in both motor and cognitive function. Combined (18)F-FDG PET/CT showed localized FDG uptake in the pons, consistent with the finding of CPM observed on magnetic resonance imaging (MRI). Read More

    A systematic review of known interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans.
    Clin Endocrinol (Oxf) 2017 Feb 18. Epub 2017 Feb 18.
    Health Economics & Outcomes Research, Otsuka Pharmaceutical Europe Ltd, UK.
    International and national guidelines on the treatment of chronic non-hypovolaemic hypotonic hyponatraemia differ; therefore we have undertaken this systematic review and meta-analysis to investigate the efficacy and safety of interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia. Following registration of the review protocol with PROSPERO, systematic literature searches were conducted to identify randomised and quasi-randomised controlled trials assessing any degree of fluid restriction or any drug treatment with the aim of increasing serum sodium concentration in patients with chronic non-hypovolaemic hypotonic hyponatraemia. Where appropriate, outcome data were synthesised in a meta-analysis. Read More

    [Hyponatremia and its etiology in pediatric patients admitted to the emergency room].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S64-S70
    Servicio de Cardiología Pediátrica, Hospital de Pediatría, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
    Background: The importance of hyponatremia is underestimated despite it is a frequent alteration in a hospital environment. Usually no cause is investigated and it is treated as an isolated data. The aim was to determine the prevalence and etiology of hyponatremia in pediatric patients. Read More

    Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH).
    Intern Med 2017 15;56(4):429-433. Epub 2017 Feb 15.
    Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
    A 76-year-old woman was diagnosed with lung tuberculosis. On the second day of anti-tuberculosis treatment, she became unconscious and developed status epilepticus accompanied by hyponatremia. The hyponatremia was caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Read More

    Tolvaptan treatment for severe neonatal autosomal-dominant polycystic kidney disease.
    Pediatr Nephrol 2017 Feb 13. Epub 2017 Feb 13.
    Radiology Department, Southampton Children's Hospital, Southampton, UK.
    Background: Severe neonatal autosomal-dominant polycystic kidney disease (ADPKD) is rare and easily confused with recessive PKD. Managing such infants is difficult and often unsuccessful.

    Case Diagnosis/treatment: A female infant with massive renal enlargement, respiratory compromise and hyponatraemia was treated with the arginine vasopressin receptor 2 antagonist tolvaptan. Read More

    Hyponatremia and cyst growth in neonatal polycystic kidney disease: a case for aquaretics?
    Pediatr Nephrol 2017 Feb 13. Epub 2017 Feb 13.
    Centre for Nephrology, University College London, London, UK.
    Hyponatremia is a common complication in neonatal polycystic kidney disease and is thought to be due to water retention. Aquaretics are drugs that promote free water excretion by blocking the arginine vasopressin receptor type 2 (AVPR2) in the collecting duct and thus impair urinary concentration. AVPR2 is also a key stimulant for cyclic AMP production in the collecting duct and in this way promotes cyst proliferation and pathologic kidney growth in autosomal dominant polycystic kidney disease (ADPKD). Read More

    Cerebral Salt-Wasting Syndrome Caused by Minor Head Injury.
    Case Rep Emerg Med 2017 17;2017:8692017. Epub 2017 Jan 17.
    Department of Neurosurgery, Tsurumi Neurosurgery, Koga, Ibaraki, Japan.
    A 34-year-old woman was admitted to hospital after sustaining a head injury in a motor vehicle accident (day 1). No signs of neurological deficit, skull fracture, brain contusion, or intracranial bleeding were evident. She was discharged without symptoms on day 4. Read More

    Cardiorenal Anemia Syndrome and Survival among Heart Failure Patients in Tanzania: A Prospective Cohort Study.
    BMC Cardiovasc Disord 2017 Feb 14;17(1):59. Epub 2017 Feb 14.
    Muhimbili University of Health and Allied Sciences, P.O Box 65001, Dar es Salaam, Tanzania.
    Background: Cardiorenal anemia syndrome (CRAS) is an evolving global epidemic associated with increased morbimortality and cost of care. The management of patients with CRAS remains a challenging undertaking worldwide and the lack of evidence-based clinical guidelines adds to the challenge. We aimed to explore the prevalence and survival rates of heart failure patients with CRAS in Tanzania. Read More

    Neurologic manifestations of major electrolyte abnormalities.
    Handb Clin Neurol 2017 ;141:705-713
    Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:
    The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Read More

    Effects of tolvaptan in patients with chronic kidney disease and chronic heart failure.
    Clin Exp Nephrol 2017 Feb 11. Epub 2017 Feb 11.
    Yokohama Rosai Hospital, Yokohama, Japan.
    Background: Tolvaptan, a vasopressin V2 receptor blocker, has a diuretic effect for patients with heart failure. However, there were a few data concerning the effects of tolvaptan in patients with chronic kidney disease (CKD).

    Methods: We retrospectively analyzed 21 patients with chronic heart failure and CKD. Read More

    Vasospasm after Craniopharyngioma surgery: Can we prevent it?
    World Neurosurg 2017 Feb 8. Epub 2017 Feb 8.
    Dept of Endocrinology, PGIMER, Chandigarh, India.
    Background: Vasospasm following craniopharyngioma surgery, though rare, has been reported. Hypotheses regarding possible causative factors including major vessel handling during surgery and tumour cyst fluid spillage do not explain vasospasm occurring in the late post operative period. We have attempted to look into the probable pathogenic mechanisms of this complication and measures to prevent it. Read More

    Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
    BMJ Case Rep 2017 Feb 10;2017. Epub 2017 Feb 10.
    Ross University School of Medicine, North Brunswick, New Jersey, USA.
    This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin. Villous adenomas are benign neoplasms with a high incidence of becoming malignant. A small percentage of villous adenomas are known to cause depletion syndrome, also referred to as the McKittrick-Wheelock syndrome, a condition characterised by secretory diarrhoea, dehydration, hyponatremia, hypokalaemia, hypochloraemia, metabolic acidosis and acute renal failure. Read More

    Hyponatremia - A rare complication of Gitelman's syndrome.
    Indian J Nephrol 2017 Jan-Feb;27(1):74-77
    Division of Nephrology, Georgetown University/Washington Hospital Center, Washington, DC 20010, USA.
    Gitelman's syndrome (GS) is a rare autosomal recessive disorder caused by mutations in thiazide-sensitive NaCl cotransporter. We report a 49-year-old, normotensive lady with prolonged hypokalemia since her 20s who was diagnosed with GS at our renal clinic. During follow-up, she was found to have mild, asymptomatic, euvolemic hyponatremia with low serum uric acid, inappropriately high urine osmolality and sodium consistent with syndrome of inappropriate antidiuretic hormone-like presentation. Read More

    Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.
    Neurology 2017 Feb 8. Epub 2017 Feb 8.
    From the Departments of Neurology (M.C.C., E.H.K., A.L.H., J.C.P., D.R.B., A.V., B.R., M.D., F.M.C., P.N.), Pediatrics (E.H.K., A.L.H.), and Anesthesiology-Critical Care Medicine (R.G.G.), Neurosurgery and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (S.H.), Mayo Clinic, Rochester, MN; Neuroscience Institute (M.K., E.C.H., D.D., T.S.), Queen's Medical Center, Honolulu, HI; Department of Neurology (B.B.), Loyola University Health System, Maywood, IL; Institute for Clinical and Translational Research (B.H.-B.), Johns Hopkins University, Baltimore, MD; and Department of Neurology (P.W.K.), Johns Hopkins Bayview Medical Center, Baltimore, MD.
    Objective: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults.

    Methods: We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Read More

    [Severe multifactorial hyponatremia].
    G Ital Nefrol 2017 Jan-Feb;34(1)
    Hyponatremia is the most common electrolyte disorder observed in hospitalized patients. The most severe forms are neurological and potentially fatal emergencies; yet increased morbidity, length of hospital stay and costs associated with less severe forms are aspects of major concern. Nephrologists are frequently consulted regarding the therapeutic management and the key pathophysiological issues of hyponatremia, as this latter aspect represents a true challenge in an emergency setting. Read More

    Diagnosis and Treatment of Hyponatremia: Compilation of the Guidelines.
    J Am Soc Nephrol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands.
    Hyponatremia is a common water balance disorder that often poses a diagnostic or therapeutic challenge. Therefore, guidelines were developed by professional organizations, one from within the United States (2013) and one from within Europe (2014). This review discusses the diagnosis and treatment of hyponatremia, comparing the two guidelines and highlighting recent developments. Read More

    "Bowel prep hyponatremia" - a state of acute water intoxication facilitated by low dietary solute intake: case report and literature review.
    BMC Nephrol 2017 Feb 7;18(1):54. Epub 2017 Feb 7.
    Fourth Department of Medicine, Section of Nephrology, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600, Wels, Austria.
    Background: Symptomatic hyponatremia is considered a rare complication of oral bowel preparation for colonoscopy. The pathophysiology underlying this phenomenon has been widely regarded as a mere sequela of excessive arginine vasopressin (AVP) release.

    Case Presentation: This case describes a 61-year old woman who developed acute hyponatremic encephalopathy when preparing for elective outpatient lower endoscopy. Read More

    Medication Induced SIADH: Distribution and Characterization According to Medication Class.
    Br J Clin Pharmacol 2017 Feb 7. Epub 2017 Feb 7.
    Medicine A, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
    Aims: To determine the distribution of aetiologies for drug induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) in hospitalized patients, and to characterize them according to the different drug groups.

    Methods: A single centre retrospective study including all patients diagnosed with SIADH in a large community hospital and tertiary centre between 1.1. Read More

    Systemic Complications Following Aneurysmal Subarachnoid Hemorrhage.
    Curr Neurol Neurosci Rep 2017 Jan;17(1)
    Department of Neurology, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL, 60153, USA.
    Many systemic complications follow aneurysmal subarachnoid hemorrhage and are primarily due to sympathetic nervous system activation. These complications play an important role in the overall outcome of patients. The purpose of this review is to provide an update on the diagnosis, pathophysiology, and management of systemic complications specifically associated with aneurysmal subarachnoid hemorrhage. Read More

    A Quick Reference on Hyponatremia.
    Vet Clin North Am Small Anim Pract 2017 Mar;47(2):213-217
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA. Electronic address:
    The article focuses on causes of hyponatremia, including hypovolemia, diabetes mellitus and others. Hypovolemia is a major cause of hyponatremia in veterinary medicine. Hypovolemia causes a decrease in effective circulating volume, triggering antidiuretic hormone (ADH) secretion and free water retention, and develops after gastrointestinal losses, renal losses, hemorrhagic shock, hypoadrenocorticism, and other causes of hypovolemia. Read More

    Cushing's Syndrome Presenting with Hyponatremia.
    Clin Lab 2016 Jul;62(7):1353-1355
    We present a case of Cushing's syndrome that presented with hyponatremia. A 64-year-old obese woman presented to the hospital emergency service complaining of a high fever, hypertension, and generalized oedema. During the examination, the patient suddenly became confused and lost consciousness. Read More

    Severe hyponatremia and repeated intestinal resections for intestinal dysmotility mimicking congenital aganglionic megacolon due to delay in the diagnosis of congenital hypothyroidism.
    Ann Pediatr Endocrinol Metab 2016 Dec 31;21(4):230-234. Epub 2016 Dec 31.
    Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Congenital hypothyroidism (CH) may present with nonspecific signs and symptoms, though, majority of infants can be asymptomatic. Therefore, understimation and delay in diagnosis may result in severe complications. A 5-month-old female admitted to our clinic with the history of repeated surgical operations due to the diagnosis of congenital aganglionic megacolon. Read More

    Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors.
    Invest New Drugs 2017 Feb 4. Epub 2017 Feb 4.
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
    Purpose Macrophage-stimulating 1-receptor (RON) is expressed on macrophages, epithelial cells, and a variety of tumors. Narnatumab (IMC-RON8; LY3012219) is a neutralizing monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP). This study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and efficacy of narnatumab in patients with advanced solid tumors. Read More

    Craniopharyngioma presenting with severe hyponatremia, hyponatremia-induced myopathy, and panhypopituitarism: a case report.
    J Med Case Rep 2017 Feb 5;11(1):31. Epub 2017 Feb 5.
    University Medical Unit, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.
    Background: Craniopharyngiomas are rare intracranial tumors commonly presenting with neurological symptoms. Reports of severe hyponatremia as a presenting manifestation of a craniopharyngioma and hyponatremia-induced myopathy are rare. We report the case of a patient with craniopharyngioma presenting with severe hyponatremia, panhypopituitarism, and hyponatremia-induced myopathy. Read More

    CJD mimics and chameleons.
    Pract Neurol 2017 Feb 2. Epub 2017 Feb 2.
    NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
    Rapidly progressive dementia mimicking Creutzfeldt-Jakob disease (CJD) is a relatively rare presentation but a rewarding one to become familiar with, as the potential diagnoses range from the universally fatal to the completely reversible. Patients require urgent decisions about assessment and investigation and have quickly evolving needs for treatments and support, through symptom management and end-of-life care in most cases. We have based this pragmatic review on the experiences of a specialist prion referral centre in the UK, which, unsurprisingly, is strongly biased towards seeing patients with CJD. Read More

    Preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients.
    Medicine (Baltimore) 2017 Feb;96(5):e6004
    aDepartment of Nuclear Medicine, Chonnam National University Hospital bDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital cDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Hospital dDepartment of Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.
    The aim of this study was to evaluate whether the preparation for radioactive iodine (RAI) therapy by thyroid hormone withdrawal (THW) or a low-iodine diet (LID) can be risk factors for the development of hyponatremia in patients with differentiated thyroid cancer after thyroidectomy.We retrospectively reviewed the medical records and laboratory findings of 326 patients who underwent preparation for RAI therapy after thyroidectomy from 2012 to 2014. Demographic and clinical variables including the method of thyrotropin stimulation and duration of LID were assessed. Read More

    Pseudomonas aeruginosa-Associated Diarrheal Diseases in Children.
    Pediatr Infect Dis J 2017 Jan 31. Epub 2017 Jan 31.
    *Department of Pediatrics, St. Paul's Hospital, Taoyuan, Taiwan; †Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; ‡School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan; and §Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
    Background: The gastrointestinal tract is not the common infection site of Pseudomonas aeruginosa. The role of P. aeruginosa as a causative agent for diarrhea in children without pre-existing disease is controversial. Read More

    Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist.
    Case Rep Pediatr 2017 9;2017:3757423. Epub 2017 Jan 9.
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    Chronic hyponatremia is very rare in children and is often seen in the setting of congestive heart failure or liver failure in adults. Here, we report an 8-year-old child with hypothalamic glioma who presented with severe hyponatremia. Initial management consisted of fluid restriction. Read More

    Complications in mechanically ventilated patients of Guillain-Barre syndrome and their prognostic value.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):68-73
    Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
    Introduction: The spectrum of various complications in critically ill Guillain-Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their significance in the prognosis and mortality.

    Materials And Methods: Retrospective case record analysis of all consecutive mechanically ventilated patients of GBS in neurology Intensive Care Unit (ICU) of a tertiary care institute for 10 years was done. Read More

    Efficacy of conivaptan and hypertonic (3%) saline in treating hyponatremia due to syndrome of inappropriate antidiuretic hormone in a tertiary Intensive Care Unit.
    Indian J Crit Care Med 2016 Dec;20(12):714-718
    Department of Intensive Care, Intensive Care Unit, Columbia Asia Referral Hospital, Bengaluru, Karnataka, India.
    Background: Hyponatremia is one of the most common electrolyte abnormalities encountered in clinical practice and has a significant impact on morbidity and mortality in hospitalized patients. The optimal management of hyponatremia is still evolving. Over the last decade, vaptans have been increasingly used in clinical practice with promising results. Read More

    Syncope: Outcomes and Conditions Associated with Hospitalization.
    Am J Med 2017 Jan 29. Epub 2017 Jan 29.
    University of Iowa Hospitals and Clinics. Iowa City, IA.
    Purpose: Syncope is a perplexing problem for which hospital admission and readmission are contemplated but outcomes remain uncertain. Our purpose was to determine the incidence of admissions and readmissions for syncope and compare associated conditions, in-hospital outcomes and resource utilization.

    Methods: The 2005-2011 California Statewide Inpatient Database was utilized. Read More

    Why do team-sport athletes drink fluid in excess when exercising in cool conditions?
    Appl Physiol Nutr Metab 2017 Mar 10;42(3):271-277. Epub 2016 Nov 10.
    Institute of Sport, Physical Activity and Leisure, G05 Carnegie Hall, Headingley Campus, Leeds Beckett University, Leeds, W. Yorkshire, United Kingdom LS6 3QS.
    This study assessed the potential physiological and perceptual drivers of fluid intake and thirst sensation during intermittent exercise. Ten male rugby players (17 ± 1 years, stature: 179.1 ± 4. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    [Takotsubo cardiomyopathy recurrence in patient with chronic kidney disease: case report and literature review].
    G Ital Nefrol 2016 Nov-Dec;33(6)
    Takotsubo cardiomyopathy (CT) is a syndrome characterized by an acute and transient left ventricular dysfunction, electrocardiographic abnormalities suggestive of acute coronary syndrome, chest pain and/or dyspnea, left ventricular mid-apical segments akinesia and normal coronary angiography. It is mainly observed in postmenopausal women after an intense physical or mental stress. The course is usually favourable but sometimes severe complications occur. Read More

    [Analysis of 5-Fluorouracil and Leucovorin Combined with Weekly Paclitaxel in Advanced Gastric Cancer].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1951-1953
    Dept. of Surgery, Kaizuka City Hospital.
    Purpose: Advanced gastric cancer patients with malignant ascites cannot tolerate S-1 plus cisplatin-containing therapy. The good toxicity profile of the FLTAX regimen(5-fluorouracil[5-FU]and Leucovorin[l-LV]combined with weekly paclitaxel) might make it a viable alternative treatment for these patients. We retrospectively evaluated the efficacy and safety of FLTAX in advanced gastric cancer patients. Read More

    An Addison disease revealed with a serious hyponatremia.
    Ann Biol Clin (Paris) 2017 Feb;75(1):87-91
    Laboratoire.
    We present the case of an Addison's disease revealed by a serious hyponatremia. The serum concentration of ACTH and 21-hydroxylase antibodies were increased and lead to the diagnosis. The cortisol blood level was lowered but required to take into account the stress induced by the hospitalisation of the patient. Read More

    Early oxytocin inhibition of salt intake after furosemide treatment in rats?
    Physiol Behav 2017 Jan 25;173:34-41. Epub 2017 Jan 25.
    Oklahoma State University - Center for Health Sciences, Tulsa, OK 74107, United States. Electronic address:
    Body fluid homeostasis requires a complex suite of physiological and behavioral processes. Understanding of the role of the central nervous system (CNS) in integrating these processes has been advanced by research employing immunohistochemical techniques to assess responses to a variety of body fluid challenges. Such techniques have revealed sex/estrogen differences in CNS activation in response to hypotension and hypernatremia. Read More

    Seasonal variations of hyponatremia in the emergency department: Age-related changes.
    Am J Emerg Med 2017 Jan 15. Epub 2017 Jan 15.
    Department of Medical, Surgical, Neurological, Metabolic and Geriatrics Sciences, University of Campania "L. Vanvitelli", Italy.
    Study Objective: We investigated seasonal prevalence of hyponatremia in the emergency department (ED).

    Design: A cross-sectional study using clinical chart review.

    Setting: University Hospital ED, with approximately 28 000 patient visits a year. Read More

    Temporal evolution of the trident and piglet signs of osmotic demyelination syndrome.
    J Neurol Sci 2017 Feb 7;373:268-273. Epub 2017 Jan 7.
    Department of Neurology & Neurotherapeurics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, United States.. Electronic address:
    Central pontine myelinolysis (CPM) is a potentially-devastating complication of rapid osmolar shifts, classically attributed to overlyaggressive correction of chronic hyponatremia. Magnetic resonance imaging (MRI) allowed earlier diagnosis of CPM, but most importantly, it has revealed that the odds of good functional recovery are surprisingly high. A trident shaped pontine lesion is a typical finding in CPM (the trident sign). Read More

    Impact of Ultrafiltration on Serum Sodium Homeostasis and its Clinical Implication in Patients With Acute Heart Failure, Congestion, and Worsening Renal Function.
    Circ Heart Fail 2017 Feb;10(2):e003603
    From the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH (T.K., Y.-H.K., W.H.W.T.); Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (J.L.G.); and Cardiovascular Division, Department of Internal Medicine, Korea University Ansan Hospital, Ansan-si, Republic of Korea (Y.-H.K.).
    Background: The relationship between changes in serum sodium with clinical events in acute heart failure patients using different decongestive events has not been investigated. This study aimed to describe changes in serum sodium levels during decongestion therapy in patients receiving stepped pharmacological therapy versus ultrafiltration.

    Methods And Results: We studied 188 patients who were enrolled in the CARRESS-HF trial (Cardiorenal Rescue Study in Acute Decompensated Heart Failure). Read More

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