15,388 results match your criteria Hyponatremia


COVID-19: A Potential Cause of Non-convulsive Status Epilepticus.

Cureus 2021 May 15;13(5):e15041. Epub 2021 May 15.

Anesthesia and Critical Care, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences, Casablanca, MAR.

Coronavirus disease 2019 (COVID-19) has been described as being primarily responsible for respiratory symptoms. Although several case reports have shown the importance of neurological manifestations, only a few have reported non-convulsive status epilepticus (NCSE) as the first manifestation of COVID-19 infection. Here, we report the case of a 30-year-old male patient with no past medical history who was admitted with altered consciousness. Read More

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Minor Head Injury Might Cause Treatable Dementia Due to Severe Hyponatremia.

Innov Clin Neurosci 2021 Jan-Mar;18(1-3):47-48. Epub 2021 Jan 1.

Dr. Nagamine is with the Sunlight Brain Research Center in Hofu, Yamaguchi, Japan.

There are several conditions of treatable dementia. Among these, hyponatremia can cause transitory modification of cognitive functions. We treated a patient with cognitive decline after minor head injury who developed severe hyponatremia due to central salt wasting syndrome (CSWS). Read More

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January 2021

Hyponatremia and Liver Transplantation: A Narrative Review.

J Cardiothorac Vasc Anesth 2021 May 23. Epub 2021 May 23.

Department of Anesthesiology and Perioperative Medicine, Penn State Health, Milton S. Hershey Medical Center/Penn State College of Medicine, Hershey, PA.

Hyponatremia is a common electrolyte disorder in patients with end-stage liver disease (ESLD) and is associated with increased mortality on the liver transplantation (LT) waiting list. The impact of hyponatremia on outcomes after LT is unclear. Ninety-day and one-year mortality may be increased, but the data are conflicting. Read More

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Brugada Pattern Phenocopy Induced by Diabetic Ketoacidosis.

Cureus 2021 May 16;13(5):e15066. Epub 2021 May 16.

Interventional Cardiology, Unity Health, Searcy, USA.

Brugada syndrome is a congenital cardiac channelopathy characterized by ST-segment elevation (≥2 mm) and subsequent inverted T wave in a minimum of two right precordial leads (Brugada type 1 ECG [electrocardiogram] pattern) on ECG. Brugada syndrome is estimated to be responsible for 4%-12% of all sudden cardiac deaths and up to 20% in patients with structurally normal hearts. Development of a temporary Brugada pattern, known as Brugada phenocopy, has been observed in individuals presenting with reversible underlying conditions such as hyperkalemia, hyponatremia, acidosis, ischemia, and pulmonary embolism, among others. Read More

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A cross-sectional survey of knowledge pertaining to IV fluid therapy and hyponatraemia among nurses working at emergency departments in Denmark.

Int Emerg Nurs 2021 Jun 14;57:101010. Epub 2021 Jun 14.

Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands; Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: Inappropriate fluid therapy may induce or worsen existing hyponatraemia with potentially life-threatening consequences. Nurses have an important role in assisting physicians in IV fluid prescribing. However, research is lacking in Denmark about nurses' knowledge pertaining to IV fluid therapy and hyponatraemia. Read More

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Osmotic Demyelination Syndrome: Clinical, Neuroimaging Characteristics, and Outcomes in a Series of 18 Cases.

Biomed Res Int 2021 28;2021:9944632. Epub 2021 May 28.

Department of Hematopathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang, China.

Objective: To investigate the etiology, clinical as well as neuroimaging characteristics, and outcomes after proper treatment in a series of 18 patients with osmotic demyelination syndrome.

Methods: Medical records, including video records, of 18 patients with osmotic demyelination syndrome were retrospectively examined. Demographic and clinical information, imaging results, plans of management, and outcomes during the follow-up period were collected and analyzed. Read More

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Central diabetes insipidus and pain medications - a risky combination.

Clin Diabetes Endocrinol 2021 Jun 16;7(1):11. Epub 2021 Jun 16.

Division of Endocrinology and Metabolism, Department of Pediatrics, Dalhousie University and IWK Health Centre, 5850/5980 University Avenue, Halifax, NS, B3K6R8, Canada.

Background: Central Diabetes Insipidus (CDI) results from decreased production of antidiuretic hormone (ADH) leading to an inability to concentrate urine. CDI is treated with desmopressin (DDAVP). Rarely reported in the literature, opioids and non-steroidal anti-inflammatories (NSAIDs) can induce hyponatremia in individuals treated for CDI. Read More

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Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town.

Ital J Pediatr 2021 Jun 16;47(1):138. Epub 2021 Jun 16.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Introduction: Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease due to the peripheral resistance to aldosterone. Its clinical spectrum includes neonatal salt loss syndrome with hyponatremia and hypochloraemia, hyperkalemia, metabolic acidosis and increased plasmatic levels of aldosterone. Two genetically distinct forms of disease, renal and systemic, have been described, showing a wide clinical expressivity. Read More

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Hyponatremia in heart failure: not just 135 to 145.

J Basic Clin Physiol Pharmacol 2021 Jun 17. Epub 2021 Jun 17.

Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

One of the most frequent in-hospital electrolyte disturbances is hyponatremia. Hyponatremia in heart failure (HF) is mainly associated with hypervolemia resulting from activation of baroreceptor-mediated hormones, such as arginine vasopressin (AVP), renin-angiotensin-aldosterone system, and catecholamines. Various electrolyte imbalance can occur as heart failure progress. Read More

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Diaphragma sellae sinking can predict the onset of hyponatremia after transsphenoidal surgery for pituitary adenomas.

J Endocrinol Invest 2021 Jun 14. Epub 2021 Jun 14.

Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.

Purpose: Sinking of the diaphragma sellae (DS) may stretch the pituitary stalk, which in turn impairs neurohypophyseal function; thus, it may play a role in the development of postoperative hyponatremia. We aimed to assess the factors influencing the development of hyponatremia after transsphenoidal surgery (TSS) for pituitary adenomas and analyze the effect of DS sinking on hyponatremia.

Methods: After applying the inclusion and exclusion criteria, we retrospectively analyzed the clinical data of patients with pituitary adenoma who underwent TSS. Read More

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Extreme Hyponatremia: Can We Go below the Analytical Range?

J Appl Lab Med 2021 Jun 14. Epub 2021 Jun 14.

Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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Dysnatremia and 6-Month Functional Outcomes in Critically Ill Patients With Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.

Crit Care Explor 2021 Jun 8;3(6):e0445. Epub 2021 Jun 8.

The Alfred Hospital, Melbourne, VIC, Australia.

Objectives: To investigate the association between plasma sodium concentrations and 6-month neurologic outcome in critically ill patients with aneurysmal subarachnoid hemorrhage.

Design: Prospective cohort study.

Setting: Eleven ICUs in Australia and New Zealand. Read More

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Relevance of maternal sodium level for preeclampsia-associated adverse pregnancy outcomes.

Pregnancy Hypertens 2021 May 29;25:110-115. Epub 2021 May 29.

Department of Obstetrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objective: To evaluate maternal sodium levels in women with preeclampsia (PE) or at high risk for preeclampsia and their relevance for severe PE-associated adverse pregnancy outcome and remaining pregnancy duration.

Study Design: In a retrospective cohort of 198 patients presenting with signs and symptoms of preeclampsia (PE), we investigated maternal sodium level and the sFlt-1/PlGF-ratio within 14 days prior to delivery.

Main Outcome Measures: In total, 88 patients (44. Read More

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Tolvaptan in the Management of Acute Euvolemic Hyponatremia After Transsphenoidal Surgery: A Retrospective Single-Center Analysis.

Front Endocrinol (Lausanne) 2021 24;12:689887. Epub 2021 May 24.

Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Introduction: Syndrome of inappropriate antidiuresis (SIAD) can be a complication of hypothalamus-pituitary surgery. The use of tolvaptan in this setting is not well established, hence the primary aim of this study was to assess the sodium correction rates attained with tolvaptan compared with standard treatments (fluid restriction and/or hypertonic saline). Furthermore, we compared the length of hospital stay in the two treatment groups and investigated the occurrence of overcorrection and side effects including osmotic demyelination syndrome. Read More

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COVID-19 Infection and Acute Kidney Injury: Cause or Complication?

Blood Purif 2021 Jun 9:1-4. Epub 2021 Jun 9.

San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.

Management of COVID-19 infection is the trend topic in the scientific community and case identification is a key step to contain the pandemic. While pneumonia and acute respiratory distress syndrome represent the typical severe manifestations of the disease, atypical presentations pose significant diagnostic and therapeutic challenges for physicians, especially when diagnostic tests are repeatedly negative. Clinical picture of COVID-19 patients is often complicated by bacterial infections or thrombotic events. Read More

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Fluoxetine for Stroke: A Mixed Bag of Outcomes.

J Clin Psychiatry 2021 Jun 8;82(3). Epub 2021 Jun 8.

Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Stroke is the leading neurologic cause of burden operationalized in terms of disability-adjusted life-years. After stroke, motor deficits, cognitive deficits, and depression cause loss of independence, disability, decreased functioning, and reduced quality of life; these persist into the long term. There are theoretical grounds to consider that, through neuroplasticity and other mechanisms, such impairments can be prevented or attenuated by the early introduction of a selective serotonin reuptake inhibitor such as fluoxetine. Read More

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[Hyponatremia in children with liver cirrhosis: Treatment strategies].

Andes Pediatr 2021 Feb 22;92(1):117-121. Epub 2021 Feb 22.

Departamento de Gastroenterología y Nutrición, Instituto Nacional de Pediatría, Ciudad de México, México.

Hyponatremia is a common hydroelectrolytic disorder in pediatric patients with advanced cirrhosis. This complication is related to the alteration in the renal capacity to eliminate free water with solutes such as sodium, which leads to disproportionate water retention, a condition known as dilutional hyponatremia. The main pathogenic factors are the non-osmotic secretion of antidiuretic hormone and the activation of the renin-angiotensin-aldosterone axis and the sympathetic nervous system. Read More

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February 2021

Successful Treatment of Pulmonary Edema Caused by Transurethral Resection of the Prostate Syndrome.

Res Rep Urol 2021 1;13:297-301. Epub 2021 Jun 1.

Department of Anesthesiology and Pain Medicine - 108 Military Central Hospital, Hanoi, Vietnam.

Background: Transurethral resection of the prostate (TURP) syndrome is a complication of transurethral resection of the prostate procedure. The incidence of TURP syndrome ranges from 0.78% to 1. Read More

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Addison's disease as a primary manifestation of extrapulmonary tuberculosis; A case report.

Indian J Tuberc 2021 Jul 6;68(3):405-407. Epub 2020 Aug 6.

Postgraduate Institute of Medicine, University of Colombo, Sri Lanka.

Tuberculosis remains an important public health problem globally. Addison's disease due to bilateral adrenal Tuberculosis as the primary manifestation of Extrapulmonary Tuberculosis is a very rare clinical entity. Previously healthy 52 years old male presented with increasing darkening of the skin, dizziness, loss of weight, loss of appetite, generalized weakness for one year and diarrhoea, vomiting for 3 months. Read More

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From hypotonic maintenance fluid to severe hyponatremia: a case report.

J Med Case Rep 2021 Jun 7;15(1):315. Epub 2021 Jun 7.

Pediatric Intensive Care Unit, CHU de Caen, 14000, Caen, France.

Background: The principles for maintenance intravenous fluid prescription in children were developed in the 1950s. These guidelines based on the use of hypotonic solutions have been challenged regularly for they seem to be associated with an increased risk of hospital-acquired hyponatremia.

Case Presentation: We report the case of a 4-week-old Caucasian child admitted for acute bronchiolitis who received hypotonic maintenance fluids and developed severe hyponatremia (94 mmol/L) with hyponatremic encephalopathy. Read More

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A Case report: Co-occurrence of IMAGe syndrome and Rhabdomyosarcoma.

Cancer Genet 2021 May 26;256-257:100-105. Epub 2021 May 26.

Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, Poland. Electronic address:

IMAGe syndrome is a rare congenital disorder, presenting with intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita and genital anomalies (in males). So far only 17 individuals have been diagnosed molecularly with IMAGe syndrome, this patient is the first case of an individual diagnosed with IMAGe and concurrent rhabdomyosarcoma. The patient was born at 30 weeks' gestation and received treatment for hyponatremia and hyperkalemia. Read More

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Hyponatremia is an independent predictor of emergency department revisits in acute exacerbation of COPD.

Clin Respir J 2021 Jun 7. Epub 2021 Jun 7.

Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital Health Sciences University, Istanbul, Turkey.

Introduction: Hyponatremia is shown to prolong hospitalization and increase mortality. The role of hyponatremia in chronic obstructive pulmonary disease is widely studied with a focus on hospitalized patients.

Objectives: To investigate whether hyponatremia increases the probability of re-exacerbations in non-hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Read More

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Development of Inappropriate Vasopressin Secretion in Association With Lumbar Cerebrospinal Fluid Drainage in an Adult With Traumatic Basilar Skull Fracture.

Authors:
Jane Rhyu Run Yu

AACE Clin Case Rep 2021 Mar-Apr;7(2):124-126. Epub 2020 Dec 28.

University of California Los Angeles (UCLA), Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, Los Angeles, California.

Objective: Hyponatremia associated with cerebrospinal fluid (CSF) drainage is primarily limited to pediatric patients. Only 1 case in an adult, after pituitary surgery, has been described. We present the first adult case, to our knowledge, of lumbar CSF drainage associated with the syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with a traumatic basilar skull fracture. Read More

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December 2020

Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish.

Front Vet Sci 2021 19;8:679970. Epub 2021 May 19.

Department of Ecology and Diseases of Zoo Animals, Game, Fish and Bees, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czechia.

Significant mortalities associated with emerging viral diseases are challenging the economy of common carp aquaculture. As such, there is an increased need to disentangle how infected fish cope with progressive disease pathology and lose the ability for homeostatic maintenance of key physiological parameters. A natural carp edema virus (CEV) infection outbreak at a carp fish farm provided an opportunity to examine diseased and healthy carp in the same storage pond, thereby contributing to our better understanding of CEV disease pathophysiology. Read More

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Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone.

Case Rep Pediatr 2021 12;2021:9920817. Epub 2021 May 12.

University of Health Sciences, Gulhane School of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey.

The use of tolvaptan to treat both euvolemic and hypervolemic hyponatremia has rapidly increased in recent years. However, data on its effects on children, especially newborns and infants, are limited. Here, we present a newborn who developed syndrome of inappropriate secretion of antidiuretic hormone following an intracranial hematoma drainage operation who was unresponsive to conventional treatments. Read More

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Maintenance fluid management in pediatrics: Current practice and quality improvement achievements.

Curr Probl Pediatr Adolesc Health Care 2021 Jun 3:100996. Epub 2021 Jun 3.

Dayton Children's Hospital, Boonshoft School of Medicine at Wright State University, United States.

The long-standing use of hypotonic fluids in pediatric maintenance fluids has been challenged in recent years due to concerns over iatrogenic hyponatremia causing morbidity and mortality. Newer research has highlighted the safety of isotonic fluid alternatives. The American Academy of Pediatrics published an evidenced-based Clinical Practice Guideline in December of 2018 (Feld et al. Read More

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Effects of copper on an omnivorous (Astyanax altiparanae) and a carnivorous fish (Hoplias malabaricus): A comparative approach.

Aquat Toxicol 2021 May 25;237:105874. Epub 2021 May 25.

Department of Physiological Sciences, State University of Londrina (UEL), Londrina, Paraná, Brazil. Electronic address:

Copper is an essential metal for life. However, in excess, it can lead to osmoregulatory disorders and oxidative stress in fish and these effects appear to be species specific. In order to evaluate the effects of copper and to compare the sensitivity of two Neotropical fishes that co-occur in nature as prey (Astyaynax altiparanae) and predator (Hoplias malabaricus), the fish were exposed to three concentrations of Cu (5 μg L, 10 μg L, and 20 μg L) for 96 h. Read More

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Osmotic demyelination syndrome and thoughts on its prevention.

J Nephrol 2021 Jun 5. Epub 2021 Jun 5.

Department of Nephrology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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BNP and NT-proBNP concentrations in paired cerebrospinal fluid and plasma samples of patients with traumatic brain injury.

J Surg Res 2021 Jun 1;266:353-360. Epub 2021 Jun 1.

Department of Neurosurgery, Jinshan Hospital of Fudan University, Shanghai, China. Electronic address:

Background: The aim of this study was to investigate the secretion patterns of brain natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP) after traumatic brain injury (TBI) and to analyze the source of them in cerebrospinal fluid (CSF).

Materials And Methods: We synchronously measured BNP and NT-proBNP concentrations in paired CSF and plasma samples from 22 moderate to severe TBI patients and 40 healthy control patients. The CSF and/or plasma ratio of albumin (Q) was calculated daily. Read More

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Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):508-510

Montefiore Nyack Hospital, Nyack, New York, United States.

Chronic ingestion of licorice is known to cause numerous metabolic and electrolyte disturbances. Severe hyponatremia, hypertension, and hypokalemia as well as metabolic alkalosis are amongst the most common consequences of chronic ingestion resulting in an apparent mineralocorticoid excess (AME). Treatment predominantly consists of cessation of licorice ingestion, potassium replenishment and aldosterone antagonists. Read More

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