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    12857 results match your criteria Hyponatremia

    1 OF 258

    Clinical signs, profound acidemia, hypoglycemia, and hypernatremia are predictive of mortality in 1,400 critically ill neonatal calves with diarrhea.
    PLoS One 2017 17;12(8):e0182938. Epub 2017 Aug 17.
    College of Veterinary Medicine, University of Illinois, Urbana-Champaign, Illinois, United States of America.
    Profound acidemia impairs cellular and organ function and consequently should be associated with an increased risk of mortality in critically ill humans and animals. Neonatal diarrhea in calves can result in potentially serious metabolic derangements including profound acidemia due to strong ion (metabolic) acidosis, hyper-D-lactatemia, hyper-L-lactatemia, azotemia, hypoglycemia, hyperkalemia and hyponatremia. The aim of this retrospective study was to assess the prognostic relevance of clinical and laboratory findings in 1,400 critically ill neonatal calves with diarrhea admitted to a veterinary teaching hospital. Read More

    Fatal Cerebral Edema, Seizures, and Hyponatremia After Trazodone Overdose.
    Clin Neuropharmacol 2017 Aug 14. Epub 2017 Aug 14.
    Department of Neurology, Geisinger Medical Center, Danville, PA.
    Trazodone is a serotonin antagonist and reuptake inhibitor that is widely used for the treatment of depression and insomnia. Fatal overdose is rare and usually occurs when combined with other drugs or alcohol. Only a few lethal cases of pure trazodone overdose have been reported, all attributed to cardiotoxicity. Read More

    Current Issues in Intravenous Fluid Use in Hospitalized Children.
    Rev Recent Clin Trials 2017 Aug 16. Epub 2017 Aug 16.
    Division of General Pediatrics and Adolescent Medicine, Julie Byerley, MD, University of North Carolina and NC Children's Hospital, Chapel Hill, NC. United States.
    Background: Fluid and electrolyte therapy is an important component in the care of the hospitalized child. Previous pediatric guidelines have followed the Holliday-Segar method of calculating and delivering maintenance IV fluids, using hypotonic fluids in maintenance therapy. However, research demonstrates that hypotonic fluids can lead to iatrogenic hyponatremia and that isotonic fluid is a safer alternative. Read More

    Evaluation of hyponatraemia in lung cancer patients: A U.K. teaching hospital experience.
    J Clin Oncol 2015 Oct;33(29_suppl):197
    Birmingham Heartlands Hospital, Birmingham, United Kingdom.
    197 Background: Hyponatraemia, defined as a serum Na < 135mEq/L, is the commonest electrolyte abnormality in oncology practice. We describe the demographics, oncological management and response of hyponatraemia to oncological treatment modalities in our patient group.

    Methods: We retrospectively analysed serum sodium levels in lung cancer patients admitted to a teaching hospital in the UK between 2007 and 2013. Read More

    Efficacy and safety of pazopanib as a subsequent treatment after failure of other targeted agents in patients with metastatic renal cell carcinoma (mRCC).
    J Clin Oncol 2012 Feb;30(5_suppl):415
    Karmanos Cancer Institute, Wayne State University, Detroit, MI; John D. Dingell VA Medical Center, Detroit, MI.
    415 Background: Pazopanib is an oral tyrosine kinase inhibitor and is currently approved for treatment of patients with advanced or mRCC in the first-line, or second-line setting, after progression on cytokine therapy. No reports of efficacy and safety are available post targeted therapy. We conducted a retrospective analysis of cases receiving pazopanib after failure of other targeted agents. Read More

    Correlation of pathologic findings after brief neoadjuvant sorafenib with results of dynamic-contrast enhanced (DCE) and diffusion-weighted magnetic resonance imaging (DW-MRI) in patients with locally advanced or metastatic clear cell renal cell carcinoma (RCC).
    J Clin Oncol 2013 Feb;31(6_suppl):466
    Feinberg School of Medicine, Northwestern University, Chicago, IL.
    466 Background: Many pts receiving tyrosine kinase inhibitors for RCC manifest stable disease as their best response by RECIST criteria. We hypothesized that tumor necrosis by DCE and DW-MRI after brief treatment with neoS may correlate with pathologic findings. We investigated in a pilot study whether these MRI changes may serve as an imaging biomarker predictive of clinical outcome. Read More

    A phase Ib trial of mushroom powder in biochemically recurrent, hormone-naive prostate cancer.
    J Clin Oncol 2013 Feb;31(6_suppl):142
    City of Hope, Duarte, CA.
    142 Background: Biochemically recurrent prostate cancer (PC) is a common presentation of relapse after primary local therapies. Strategies to delay disease progression and defer initiation of androgen deprivation therapy and associated side effects are needed. White button mushroom (WBM, Agaricus bisporus) extract suppresses prostate cancer tumor growth in animals, and prior human experience indicates favorable toxicity profile. Read More

    Assessment of knowledge of vincristine toxicities in outpatient pediatric hematology/oncology nurses: An educational intervention.
    J Clin Oncol 2013 Nov;31(31_suppl):231
    Childrens Hospital Los Angeles, Los Angeles, CA.
    231 Background: Vincristine (VCR) is a chemotherapeutic agent with a unique neurological side effect profile and is integral to the treatment of many pediatric hematological and solid malignancies. Side effects requiring VCR dose modification include peripheral neuropathies, intestinal ileus, cranial nerve abnormalities, hyponatremia and seizures. In our institution, orders for weekly VCR are written in advance by oncologists and administered by outpatient nurses independent of a provider physical examination. Read More

    Syndrome of inappropriate anti-diuresis induces volume-dependent hypercalciuria.
    Osteoporos Int 2017 Aug 15. Epub 2017 Aug 15.
    CHU de Rangueil, Service des Explorations Fonctionnelles Physiologiques, 1, Avenue du Professeur Jean Poulhès-TSA 50032, 310599, Toulouse Cedex, France.
    Hyponatremia is associated with bone demineralization. We hypothesized that, during hyponatremia, calciuria and calcium balance depend on volemic status. We evaluated calciuria in patients with hyponatremia, secondary to SIAD or hypovolemia. Read More

    Evaluation of Adrenal Function in Nonhospitalized Patients with Cirrhosis.
    Can J Gastroenterol Hepatol 2017 24;2017:2354253. Epub 2017 Jul 24.
    Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Patients with cirrhosis and advancing hepatic insufficiency may show various degrees of other organ malfunction, including brain, kidney, and lung. Several studies have also shown a high prevalence of adrenal insufficiency in cirrhotic patients that may cause hemodynamic instability.

    Materials And Methods: In this study we prospectively evaluated adrenal function in a population of nonhospitalized cirrhotic patients. Read More

    [Hyponatremia: Differential Diagnosis and Treatment].
    Dtsch Med Wochenschr 2017 Aug 15;142(16):1231-1247. Epub 2017 Aug 15.
    Hyponatremia is the most common electrolyte abnormality seen in hospitalized patients, with up to 30 % having a plasma sodium concentration below 135 mmol/l. It is now clear that the clinical problem extends beyond the neurological symptoms, which can be explained by intracerebral osmotic fluid shifts and brain edema. Instead, chronic hyponatremia is associated with impaired gait stability and an increased risk of bone fragility fractures. Read More

    Prevalence of Hyponatremia in Patients with Elderly Hip Fracture: A Two-year Study.
    Med Princ Pract 2017 Aug 14. Epub 2017 Aug 14.
    Objective: This study investigated the prevalence of hyponatremia in elderly patients (≥ 65 years) with hip fractures.

    Subjects And Methods: All records containing clinical and laboratory information of the 334 elderly patients admitted with hip fractures to the San Giovanni di Dio e Ruggi d'Aragona Hospital of Salerno (Italy) during 2014 and 2015 were retrieved from the hospital database. Patients were divided into 4 different groups, according to sex and type of hip fracture. Read More

    Electrolytes: Oral Electrolyte Solutions.
    FP Essent 2017 Aug;459:35-38
    Fort Belvoir Community Hospital, 9300 DeWitt Loop, Fort Belvoir, VA 22060.
    Oral electrolyte solutions are used widely for rehydration in diarrheal illness and to maintain hydration during vigorous exercise. In diarrheal illness, an oral rehydration solution (ORS) typically is preferred over intravenous fluids except for patients with severe dehydration. The preferred ORS is one similar to the glucose-containing reduced osmolarity World Health Organization ORS. Read More

    Electrolytes: Sodium Disorders.
    FP Essent 2017 Aug;459:11-20
    Womack Army Medical Center, 2817 Reilly Road, Fort Bragg, NC 28310.
    Sodium disorders (ie, hyponatremia, hypernatremia) are common electrolyte disturbances in clinical medicine and are associated with increased rates of morbidity and mortality. Etiologies of hyponatremia are classified into four categories. The first is pseudohyponatremia, in which the sodium level is low due to hyperproteinemia, hyperlipidemia, or hyperglycemia. Read More

    Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis.
    J Small Anim Pract 2017 Aug 14. Epub 2017 Aug 14.
    Clinic for Small Animals, Freie Universität Berlin, Oertzenweg 19b, D-14163 Berlin.
    Objective: To report clinical, laboratory and diagnostic imaging features and prognostic factors in dogs with leptospirosis from North-East Germany.

    Materials And Methods: Medical records of dogs diagnosed with leptospirosis from 2006 to 2013 were evaluated retrospectively.

    Results: The study included 99 dogs. Read More

    Differences in Associations of Antidepressants and Hospitalization Due to Hyponatremia.
    Am J Med 2017 Aug 10. Epub 2017 Aug 10.
    Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. Electronic address:
    Background Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are important as a cause for hyponatremia. However, most studies have focused on the effect on sodium levels regardless of clinical symptoms or been too small to be able to discriminate between the effects of specific antidepressant drugs. The objective of the present study was to investigate the association between different groups of antidepressants and the risk of hospitalisation due to hyponatremia. Read More

    Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody.
    Mult Scler 2017 Aug 1:1352458517726593. Epub 2017 Aug 1.
    Department of Paediatric Neurology, Great Ormond Street Hospital for Children, London, UK.
    The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. Read More

    A mechanism based approach to management of children with end-stage liver disease.
    Expert Rev Gastroenterol Hepatol 2017 Aug 14. Epub 2017 Aug 14.
    a Pediatric Transplant Hepatology, Organ Transplant and Hepatobiliary Surgery , King Abdulaziz Specialized Children's Hospital , Riyadh.
    Introduction: Due to parallel advances in surgical and acute care disciplines, liver transplantation (LT) has revolutionized the outlook for children with end-stage liver disease (ESLD). Contrary to advances in technical aspects of LT and the peri-operative care, pre-transplant management of ESLD remains quite a formidable challenge. Areas covered: This review provides mechanisms based management strategies to address common complications of ESLD including malnutrition, amended metabolic pathways, gastrointestinal dysfunction, and development of ascites. Read More

    Low-dose tolvaptan PK/PD: comparison of patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion to healthy adults.
    Eur J Clin Pharmacol 2017 Aug 12. Epub 2017 Aug 12.
    Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.
    Purpose: Tolvaptan (TLV) is indicated to treat hyponatremia due to syndrome of inappropriate diuretic hormone (SIADH) in Europe. Treatment is to be initiated at 15 mg QD but post-approval reporting indicates increasing use of 7.5 mg as the starting dose. Read More

    Tetraparesia: an unusual presentation of disseminated tuberculosis.
    BMJ Case Rep 2017 Aug 10;2017. Epub 2017 Aug 10.
    Department of Internal Medicine, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.
    A 48-year-old man with a 4 months history of asthenia, anorexia, 10 kg weight loss and 1 month of hematuria and dysuria was admitted to another hospital for sudden muscular weakness. He was found to have areflexic tetraparesis and was referred to our hospital.On admission, he was bradycardic, tachypneic, with flaccid tetraplegia. Read More

    Physiological Mechanisms of Water and Electrolyte Disturbances Following Transsphenoidal Pituitary Surgery.
    World Neurosurg 2017 Aug 7. Epub 2017 Aug 7.
    University of Mississippi Medical Center, Department of Physiology and Biophysics, Center for Computational Medicine, Jackson, Mississippi, USA. Electronic address:
    Background: Disturbances in water and electrolyte homeostasis are common following transsphenoidal surgery. These disorders are variable and unpredictable, increasing patient risk and complicating postsurgical treatment. Clinically, it is generally accepted that damage to the pituitary is the etiology, but the mechanisms behind the response variability and underlying pathophysiology remains unknown. Read More

    Associations between hyponatraemia, volume depletion and the risk of falls in US hospitalised patients: a case-control study.
    BMJ Open 2017 Aug 7;7(8):e017045. Epub 2017 Aug 7.
    Clinical and Translational Science Institute, University of Florida, Gainesville, Florida, USA.
    Objective: We aimed to determine if abnormal laboratory values which may indicate volume depletion are associated with increased odds of experiencing a hospital-acquired fall.

    Design: Matched case-control study.

    Setting: Four hospitals located in the Southeast USA. Read More

    Albumin Use in Patients With Cirrhosis in France: Results of the "ALBU-LIVE" Survey: A Case for Better EASL Guidelines Diffusion and/or Revision.
    J Clin Gastroenterol 2017 Aug 4. Epub 2017 Aug 4.
    *Service d'Hépato-gastroentérologie, de Nutrition et d'Alcoologie, GHPSO, Creil †Service d'Hépato-gastroentérologie, Centre Hospitalier de Gonesse, Gonesse ‡Service d'Hépato-gastroentérologie, CHRU La Cavale Blanche, Brest §Service d'Hépatologie, CHRU Jean Minjoz, Besançon ∥Service d'Hépato-gastroentérologie, CHU, Caen ¶Service d'Hépatologie, CHRU, Lille #Service d'Hépatologie, CHU Cochin §§Service d'Hépatologie, CHU Pitié-Salpêtrière ‡‡‡Service d'Hépatologie, CHU Saint-Antoine ∥∥∥Service d'Hépato-gastroentérologie, CHU Tenon, Paris **Service d'Hépato-gastroentérologie, Centre Hospitalier, Tourcoing ††Service d'Hépatologie, Centre Hépatobiliaire, Villejuif ‡‡Service d'Hépato-gastroentérologie †††Service de Médecine Interne, CHU, Toulouse ∥∥Service d'Hépatologie, CHU Beaujon, Clichy-la-Garenne ¶¶Service d'Hépato-gastroentérologie, Centre Hospitalier, Montfermeil ##Service d'Hépato-gastroentérologie, Centre Hospitalier, Lagny-sur-Marne ***Service d'Hépatologie, CHU, Reims §§§Service d'Hépato-gastroentérologie, Centre Hospitalier, Saint-Denis ¶¶¶Service d'Hépato-gastroentérologie, CHU, Clermont-Ferrand ###Cabinet médical, Montpellier ****Service d'Hépato-gastroentérologie, CHU, Grenoble ††††Service d'Hépato-gastroentérologie, CHU, Pessac ‡‡‡‡Service d'Hépato-gastroentérologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
    Introduction: The use of human albumin for the management of cirrhosis has increased. Recommendations have been published for therapeutic paracentesis (TP), spontaneous bacterial peritonitis (SBP), and type 1 hepatorenal syndrome (HRS). The goal of this survey was to assess the prescription practices of French hepatogastroenterologists. Read More

    Recrudescence of Deficits After Stroke: Clinical and Imaging Phenotype, Triggers, and Risk Factors.
    JAMA Neurol 2017 Aug 7. Epub 2017 Aug 7.
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.
    Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon.

    Objective: To investigate the clinical features, triggers, and risk factors for PSR.

    Design, Setting, And Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. Read More

    Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.
    J Clin Invest 2017 Aug 7. Epub 2017 Aug 7.
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, United Kingdom.
    Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse effect, is poorly understood. Here, we have studied the phenotypic and genetic characteristics of patients hospitalized with TIH. In a cohort of 109 TIH patients, those with severe TIH displayed an extended phenotype of intravascular volume expansion, increased free water reabsorption, urinary prostaglandin E2 excretion, and reduced excretion of serum chloride, magnesium, zinc, and antidiuretic hormone. Read More

    Managing hyponatraemia secondary to primary polydipsia: beware too rapid correction of hyponatraemia.
    Intern Med J 2017 Aug;47(8):956-959
    Diabetes and Endocrinology Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
    We describe three cases of severe hyponatraemia in the setting of primary polydipsia that were managed in our centre in 2016. Despite receiving different solute loads, large volume diuresis and rapid correction of serum sodium occurred in all cases. Given the potentially catastrophic consequence of osmotic demyelination, we highlight the judicious use of desmopressin and hypotonic fluid infusion to mitigate sodium overcorrection in this setting. Read More

    Morvan syndrome: a rare cause of syndrome of inappropriate antidiuretic hormone secretion.
    Clujul Med 2017 15;90(3):353-355. Epub 2017 Jul 15.
    Department of Internal Medicine, Gulhane Training and Research Hospital, Ankara, Turkey.
    The syndrome of inappropriate antidiuretic hormone secretion (SIADH) accounts for an important part of hyponatremia cases. The causes of SIADH can be detected almost always. As a rare disorder, Morvan Syndrome can be defined by the sum of peripheral nerve hyperexcitability, autonomic instability and neuropsychiatric features. Read More

    Exercise-Associated Hyponatremia, Hypernatremia, and Hydration Status in Multistage Ultramarathons.
    Wilderness Environ Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA (Dr Rundell).
    Objective: Dysnatremia and altered hydration status are potentially serious conditions that have not been well studied in multistage ultramarathons. The purpose of this study was to assess the incidence and prevalence of exercise-associated hyponatremia (EAH) (Na(+) <135 mmol·L(-1)) and hypernatremia (Na(+) >145 mmol·L(-1)) and hydration status during a multistage ultramarathon.

    Methods: This study involved a prospective observational cohort study of runners competing in a 250-km (155-mile) multistage ultramarathon (in the Jordan, Atacama, or Gobi Desert). Read More

    Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.
    Cancer Chemother Pharmacol 2017 Aug 4. Epub 2017 Aug 4.
    Centre for Physiology and Pharmacology, Institute of Pharmacology, Medizinische Universität Wien, Währingerstraße 13A, 1090, Vienna, Austria.
    Purpose: Small-molecule inhibitors of heat-shock protein 90 (HSP90) have been under development as chemotherapeutic agents. The adverse events reported from early clinical trials included hyponatremia. Given the limited number of patients enrolled, the number of hyponatremia incidents was remarkable and repeatedly, the event was judged as severe. Read More

    Current Management of Hyponatremia in Acute Heart Failure: A Report From the Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia (HN Registry).
    J Am Heart Assoc 2017 Aug 3;6(8). Epub 2017 Aug 3.
    The University of Texas at Austin College of Pharmacy, Hutto, TX.
    Background: Hyponatremia (HN) occurs commonly in patients with acute heart failure and confers a worse prognosis. Current HN treatment varies widely, with no consensus. This study recorded treatment practices currently used for patients hospitalized with acute heart failure and HN. Read More

    Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review.
    Intern Med 2017 1;56(15):1993-1999. Epub 2017 Aug 1.
    Department of Emergency and Critical Care Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
    A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. Read More

    A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer.
    Gastric Cancer 2017 Aug 1. Epub 2017 Aug 1.
    Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
    Background: A combination of S-1 and cisplatin is recognized as one of the standard first-line chemotherapy regimens for patients with advanced gastric cancer. However, demographic analyses of pivotal phase III studies have showed that only a minority of treated patients were aged 76 years or older. The purpose of this phase II study was to evaluate the safety and efficacy of combination therapy with S-1 and cisplatin in elderly patients with chemotherapy-naive advanced gastric cancer. Read More

    Use and safety of antiepileptic drugs in psychiatric inpatients-data from the AMSP study.
    Eur Arch Psychiatry Clin Neurosci 2017 Aug 1. Epub 2017 Aug 1.
    Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
    The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%. Read More

    Performance of Disease-Specific Scoring Models in Intensive Care Patients with Severe Liver Diseases.
    J Clin Diagn Res 2017 Jun 1;11(6):OC12-OC16. Epub 2017 Jun 1.
    Lecturer, Department of Biostatistics, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
    Introduction: Egypt has the highest prevalence of Hepatitis C Virus (HCV) in the world, estimated nationally at 14.7%. HCV treatment consumes 20% ($80 million) of Egypt's annual health budget. Read More

    Hyponatremia in refractory congestive heart failure patients treated with icodextrin-based peritoneal dialysis: A case series.
    Nefrologia 2017 Jul 28. Epub 2017 Jul 28.
    Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel-Hashomer, Israel.
    Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed to be a good option for fluid removal in such patients. Read More

    Dietary Approaches in the Management of Diabetic Patients with Kidney Disease.
    Nutrients 2017 Jul 31;9(8). Epub 2017 Jul 31.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, School of Medicine, Orange, CA 92868, USA.
    Chronic kidney disease (CKD) is one of the most prevalent complications of diabetes, and patients with diabetic kidney disease (DKD) have a substantially higher risk of cardiovascular disease and death compared to their non-diabetic CKD counterparts. In addition to pharmacologic management strategies, nutritional and dietary interventions in DKD are an essential aspect of management with the potential for ameliorating kidney function decline and preventing the development of other end-organ complications. Among DKD patients with non-dialysis dependent CKD, expert panels recommend lower dietary protein intake of 0. Read More

    [Serious adverse drug reactions with tramadol reported to the French pharmacovigilance database between 2011 and 2015].
    Therapie 2017 Jun 29. Epub 2017 Jun 29.
    Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, faculté de médecine, CHU, 37, allées Jules-Guesde, 31000 Toulouse, France; Laboratoire de pharmacologie médicale et clinique, faculté de médecine, 31000 Toulouse, France.
    Background: Tramadol is an opioid and a serotonin reuptake inhibitor drug. It is approved for moderate to severe pain in adults. The aim of this study was to assess tramadol safety through a national pharmacovigilance study in France since dextropropoxyphen withdrawal in 2011. Read More

    Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.
    Drug Saf 2017 Jul 27. Epub 2017 Jul 27.
    Department of Research and Development, BIAL-Portela & Cª, S.A., 4745-457, Coronado (S. Romão e S. Mamede), Portugal.
    Introduction: Eslicarbazepine acetate was first approved in the European Union in 2009 as adjunctive therapy in adults with partial-onset seizures with or without secondary generalization.

    Objective: The objective of this study was to review the safety profile of eslicarbazepine acetate analyzing the data from several clinical studies to 6 years of post-marketing surveillance.

    Methods: We used a post-hoc pooled safety analysis of four phase III, double-blind, randomized, placebo-controlled studies (BIA-2093-301, -302, -303, -304) of eslicarbazepine acetate as add-on therapy in adults. Read More

    Corrigendum to "Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist".
    Case Rep Pediatr 2017 2;2017:8132129. Epub 2017 Jul 2.
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    [This corrects the article DOI: 10.1155/2017/3757423.]. Read More

    Prediction of potentially avoidable readmission risk in a division of general internal medicine.
    Swiss Med Wkly 2017 Jul 27;147:w14470. Epub 2017 Jul 27.
    Centre Hospitalier Universitaire Vaudois.
    Introduction: The 30-day post-discharge readmission rate is a quality indicator that may reflect suboptimal care. The computerised algorithm SQLape® can retrospectively identify a potentially avoidable readmission (PARA) with high sensitivity and specificity. We retrospectively analysed the hospital stays of patients readmitted to the Department of Internal Medicine of the CHUV (Centre Hospitalier Universitaire Vaudois) in order to quantify the proportion of PARAs and derive a risk prediction model. Read More

    Gitelman syndrome: an analysis of the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities.
    Int Urol Nephrol 2017 Jul 25. Epub 2017 Jul 25.
    Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece.
    Gitelman syndrome is the most common inherited tubular disease resulting from mutations of the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter in the early distal convoluted tubules. The review presents the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities observed in patients with Gitelman syndrome. The syndrome is usually characterized by hypokalemic metabolic alkalosis in combination with hypomagnesemia and hypocalciuria. Read More

    Acute severe diarrhoea and hyponatremia after zoledronic acid infusion: an acute phase reaction.
    Clin Cases Miner Bone Metab 2017 Jan-Apr;14(1):101-104. Epub 2017 May 30.
    Division of Endocrinology and Diabetes, Medanta-The Medicity, Sector 38, Gurgaon, Haryana, India.
    Zoledronic acid (ZA), an intravenous aminobisphosphonate, is prescribed widely for postmenopausal osteoporosis. It is a relatively safe drug but may cause adverse effects including acute phase reaction. Oral non-aminobisphosphonates are known to cause diarrhoea that is usually mild and self-limited. Read More

    Clinical Characteristics and Prognosis of Elderly Small Cell Lung Cancer Patients Complicated with Hyponatremia: A Retrospective Analysis.
    Anticancer Res 2017 Aug;37(8):4681-4686
    Department of Oncology, Yantai Yuhuangding Hospital, Affiliated with Medical College of Qingdao University, Yantai, P.R. China
    Aim: This study was designed to evaluate the clinical characteristics and prognosis of elderly small cell lung cancer (SCLC) patients complicated with hyponatremia, thus providing increased attention for appropriate intervention and improving outcomes in symptomatic subjects.

    Patients And Methods: The clinical data of 320 patients with SCLC in the Yuhuangding Hospital from March 1st, 2006, to March 1st, 2012, were studied retrospectively. The prognosis and possible association with hyponatremia was investigated. Read More

    Management of cirrhotic ascites in children. Review and recommendations. Part 1: Pathophysiology, diagnostic evaluation, hospitalization criteria, treatment, nutritional management.
    Arch Argent Pediatr 2017 Aug;115(4):385-390
    CHU-Sainte Justine, Montreal, Canadá.
    Ascites is a major complication of cirrhosis. There are several evidence-based articles and guidelines for the management of adults, but few data have been published in relation to children. In the case of pediatric patients with cirrhotic ascites (PPCA), the following questions are raised: How are the clinical assessment and ancillary tests performed? When is ascites considered refractory? How is it treated? Should fresh plasma and platelets be infused before abdominal paracentesis to prevent bleeding? What are the hospitalization criteria? What are the indicated treatments? What complications can patients develop? When and how should hyponatremia be treated? What are the diagnostic criteria for spontaneous bacterial peritonitis? How is it treated? What is hepatorenal syndrome? How is it treated? When should albumin be infused? When should fluid intake be restricted? The recommendations made here are based on pathophysiology and suggest the preferred approach to its diagnostic and therapeutic aspects, and preventive care. Read More

    Increased Risk of Drug-Induced Hyponatremia during High Temperatures.
    Int J Environ Res Public Health 2017 Jul 22;14(7). Epub 2017 Jul 22.
    Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå 901 85, Sweden.
    Purpose: To investigate the relationship between outdoor temperature in Sweden and the reporting of drug-induced hyponatremia to the Medical Products Agency (MPA).

    Methods: All individual adverse drug reactions (ADR) reported to MPA from 1 January 2010 to 31 October 2013 of suspected drug-induced hyponatremia and random controls were identified. Reports where the ADR had been assessed as having at least a possible relation to the suspected drug were included. Read More

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