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    1 OF 254

    Hyponatremia Is Associated with Worse Outcomes from Fall Injuries in the Elderly.
    Int J Environ Res Public Health 2017 Apr 26;14(5). Epub 2017 Apr 26.
    Division of Trauma Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niao-Song District, Kaohsiung City 833, Taiwan.
    Background: Hyponatremia has been proposed as a contributor to falls in the elderly, which have become a major global issue with the aging of the population. This study aimed to assess the clinical presentation and outcomes of elderly patients with hyponatremia admitted due to fall injuries in a Level I trauma center. Methods: We retrospectively reviewed data obtained from the Trauma Registry System for trauma admissions from January 2009 through December 2014. Read More

    Osmotic Demyelination Syndrome due to Severe Hyponatremia Mimicking Hypoxic Encephalopathy.
    Fortschr Neurol Psychiatr 2017 Apr 24;85(4):212-215. Epub 2017 Apr 24.
    Neurologie, Sankt Katharinen Krankenhaus, Frankfurt am Main.
    Hyponatremia and its rapid correction is a well-known cause of osmotic demyelination most commonly affecting the pons. We report on a case of severe hyponatremia likely due to psychogenic polydipsia resulting in hypotonic hyperhydration with resulting cortical laminar necrosis on initial imaging, mimicking hypoxic brain damage. Pontine myelinolysis became apparent on follow-up imaging, illustrating the diagnostic challenges of extrapontine manifestations of severe hyponatremia. Read More

    Transurethral Resection of the Prostate, Bladder Explosion and Hyponatremic Encephalopathy: A Rare Case Report of Malpractice.
    Open Med (Wars) 2017 Jan 31;12:50-57. Epub 2017 Mar 31.
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy.
    We present an original case report of a bladder explosion during a TURP intervention for benign prostatic hypertrophy, that was brought on by the absorption of about 5 liters of glycine 1.5% and then onset of a severe hyponatremia. The quick and inappropriate correction of this electrolyte imbalance led the onset of encephalopathy and the death of the patient. Read More

    Carbonic anhydrase XII functions in health and disease.
    Gene 2017 Apr 19. Epub 2017 Apr 19.
    Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
    Human CAXII was initially identified as a cancer marker in different cancers and tumors. Expression of CAXII is regulated by hypoxia and estrogen receptors. CAXII expression has been also detected in several tissues, whereas in cancer and tumor tissues its expression is several fold higher. Read More

    Phosphate imbalance in patients with heart failure.
    Heart Fail Rev 2017 Apr 22. Epub 2017 Apr 22.
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10, Ioannina, Greece.
    Patients with heart failure often exhibit electrolyte abnormalities, such as hyponatremia or hypokalemia/hyperkalemia. Although not as common as the other electrolyte disturbances observed in patients with heart failure, phosphate imbalance is also of high importance in this population. The aim of this review is to present the mechanisms of low or high phosphate serum levels in patients with heart failure and its role in the pathogenesis and progression of heart dysfunction. Read More

    Vasopressin and Vasopressin Antagonists in Heart Failure.
    Handb Exp Pharmacol 2017 Apr 22. Epub 2017 Apr 22.
    Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Despite the introduction of multiple new pharmacological agents over the past three decades in the field of heart failure (HF), overall prognosis remains poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy. Elevated levels of arginine vasopressin (AVP), a peptide hormone produced in the hypothalamus, play a role in development of hyponatremia, and AVP and its surrogate, copeptin, are related to changes in osmolality, hemodynamics, neuro-hormones as well as in overall outcome in HF patients. Read More

    Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort.
    BMC Infect Dis 2017 Apr 20;17(1):295. Epub 2017 Apr 20.
    Department of Infectious Diseases, Northwick Park Hospital, Northwest London Teaching Hospitals NHS Trust, London, UK.
    Background: Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary tuberculosis and the associations and predictive ability of admission blood tests with clinical outcomes. Read More

    [Non-Convulsive Status Epilepticus Caused by Hyponatremia in an Elderly Woman: A Case Report].
    Brain Nerve 2017 Apr;69(4):489-492
    Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center.
    We report the case of a 67-year-old woman with non-convulsive status epilepticus (NCSE) due to hyponatremia. She had a history of psychogenic polydipsia but not epilepsy. She was admitted to our hospital with dysbulia. Read More

    Prevention of the Osmotic Demyelination Syndrome after Liver Transplantation: A Multidisciplinary Perspective.
    Am J Transplant 2017 Apr 19. Epub 2017 Apr 19.
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
    The osmotic demyelination syndrome (ODS) is a serious neurologic condition that occurs in the setting of rapid correction of hyponatremia. It presents with protean manifestations, from encephalopathy to the "locked-in" syndrome. ODS can complicate liver transplantation (LT), and its incidence may increase with the inclusion of serum sodium as a factor in the Model for End-Stage Liver Disease score. Read More

    Thiazide-Associated Hyponatremia, Report of the Hyponatremia Registry: An Observational Multicenter International Study.
    Am J Nephrol 2017 Apr 19;45(5):420-430. Epub 2017 Apr 19.
    Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne, Germany.
    Background: Hyponatremia is a frequent and potentially life-threatening adverse side effect of thiazide diuretics. This sub-analysis of the Hyponatremia Registry database focuses on current management practices of thiazide-associated hyponatremia (TAH) and compares differences between TAH and syndrome of inappropriate antidiuretic hormone secretion (SIADH).

    Methods: We analyzed 477 patients from 225 US and EU sites with euvolemic hyponatremia ([Na+] ≤130 mEq/L) who were receiving a thiazide diuretic. Read More

    Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS.
    J Clin Virol 2017 Mar 31;91:25-30. Epub 2017 Mar 31.
    Department of Infectious Diseases, University Hospital Center "Mother Theresa", Tirana, Albania.
    Background: Hemorrhagic fever with renal syndrome (HFRS) is a rodent borne zoonosis, caused by the members of the family Bunyaviridae, genus Hantavirus. The main clinical features of the infection by this virus family are fever, thrombocytopenia and acute kidney injury.

    Objective: The aim of our study was to identify, for the first time, characteristic features of HFRS in the Albanian population. Read More

    Clinical and radiological spectrum of intracranial tuberculosis: A hospital based study in Northeast India.
    Indian J Tuberc 2017 Apr 16;64(2):109-118. Epub 2016 Dec 16.
    Senior Resident, Department of Neurology, Gauhati Medical College and Hospital, Indrapur, Guwahati, India.
    Central nervous system tuberculosis (TB) is the most severe extra pulmonary TB having a high mortality and morbidity.

    Objective: To study the various clinical, biochemical, and radiological spectrum of intracranial TB.

    Materials And Method: Ninety-three patients were enrolled in this prospective study after ethical clearance and consent from August 2013 to May 2015. Read More

    Incidence and Predictors of Advanced Liver Fibrosis by a Validated Serum Biomarker in Liver Transplant Recipients.
    Can J Gastroenterol Hepatol 2017 19;2017:4381864. Epub 2017 Mar 19.
    Division of Gastroenterology and Hepatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
    Background and Aims. Serum fibrosis biomarkers have shown good accuracy in the liver transplant (LT) population. We employed a simple serum biomarker to elucidate incidence and predictors of advanced fibrosis after LT over a long follow-up period. Read More

    Hyponatremia and Hypotonic Intravenous Fluids Are Associated With Unfavorable Outcomes of Bronchiolitis Admissions.
    Hosp Pediatr 2017 Apr 13. Epub 2017 Apr 13.
    Division of Pediatric Critical Care, Rainbow Babies & Children's Hospital, Cleveland, Ohio.
    Objectives: Hyponatremia has been associated with unfavorable outcomes when present at admission in children with bronchiolitis. Delayed hyponatremia may be a modifiable risk factor for severe disease that is influenced by intravenous fluid (IVF) tonicity. We hypothesized that both hyponatremia and prescription of severely hypotonic IVF are associated with unfavorable outcomes, and that prescription of severely hypotonic IVF is associated with subsequent hyponatremia. Read More

    Autoimmune hemolytic anemia associated with babesiosis.
    Biomark Res 2017 8;5:14. Epub 2017 Apr 8.
    Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
    Background: Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is known to be caused by parasitic and viral infections but has not been well characterized. Read More

    Anesthetic Management of Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) in a High-Risk Pregnancy: A Case Report.
    A A Case Rep 2017 Apr 10. Epub 2017 Apr 10.
    From the *Department of Anesthesiology, University of Toronto; and †Department of Anesthesia and Pain Management, Mount Sinai Hospital, Toronto, Ontario, Canada.
    MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and stroke-like symptoms) is a rare and complex mitochondrial disorder. We present the in-hospital course of a 36-year-old gravida 2, para 0 with MELAS syndrome and severe preeclampsia, complicated by hyponatremia, hyperkalemia, and diabetes. A retained placenta with postpartum hemorrhage required urgent instrumental delivery under spinal anesthesia, transfusion, and intensive care unit admission for pulmonary edema, effusions, and atelectasis. Read More

    Diagnosis of myxedema coma complicated by renal failure: a case report.
    Clin Case Rep 2017 Apr 21;5(4):399-402. Epub 2017 Feb 21.
    Department of General Medicine Himi Municipal Hospital Kanazawa Medical University 31-9 Saiwai-cho Himi Toyama Japan.
    Myxedema coma, caused by severe lack of thyroid hormone, is characterized by deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. We describe an 84-year-old woman who presented with renal failure and new onset severe hypothyroidism leading to challenges in the recognition of myxedema coma. Read More

    A Study of Hyponatremia in Acute Encephalitis Syndrome: A Prospective Study From a Tertiary Care Center in India.
    J Intensive Care Med 2017 Jan 1:885066617701422. Epub 2017 Jan 1.
    1 Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Purpose: To evaluate the frequency and causes of hyponatremia in acute encephalitis syndrome (AES) and its effect on outcome.

    Patients And Methods: Consecutive patients with AES were subjected to neurological evaluation including Glasgow Coma Scale, focal weakness, movement disorder, and reflex changes. The etiology of AES was based on blood and cerebrospinal fluid enzyme-linked immunosorbent assay and polymerase chain reaction. Read More

    Syndrome of inappropriate antidiuretic hormone secretion associated with seronegative neuromyelitis optica spectrum disorder.
    Kidney Res Clin Pract 2017 Mar 31;36(1):100-104. Epub 2017 Mar 31.
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
    The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum disorders are rare. NMO is a demyelinating disorder characterized by optic neuritis and transverse myelitis. Read More

    Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis.
    Case Rep Neurol Med 2017 14;2017:1471096. Epub 2017 Mar 14.
    Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA; Illinois Neurological Institute, OSF St. Francis Medical Center, Peoria, IL, USA.
    Central pontine myelinolysis (CPM) is an acute demyelinating neurological disorder affecting primarily the central pons and is frequently associated with rapid correction of hyponatremia. Common clinical manifestations of CPM include spastic quadriparesis, dysarthria, pseudobulbar palsy, and encephalopathy of various degrees; however, coma, "locked-in" syndrome, or death can occur in most severe cases. Rarely, CPM presents with neuropsychiatric manifestations, such as personality changes, acute psychosis, paranoia, hallucinations, or catatonia, typically associated with additional injury to the brain, described as extrapontine myelinolysis (EPM). Read More

    Pitfalls in Interventional Pain Medicine: Hyponatremia after DDAVP for a Patient with Von Willebrand Disease Undergoing an Epidural Steroid Injection.
    Case Rep Anesthesiol 2017 14;2017:6467090. Epub 2017 Mar 14.
    Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
    Desmopressin (DDAVP), a synthetic analog of vasopressin, has been used in patients with von Willebrand disease (VWD), mild hemophilia A, and platelet dysfunction to reduce the risk of bleeding associated with surgical and interventional procedures. We report the case of a patient with VWD presenting with a bulging disc and radicular pain that underwent transforaminal epidural steroid injections. Her course was complicated with the interval development of headaches and dizziness symptomatic of moderate hyponatremia, likely due to excessive fluid intake. Read More

    Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.
    Oncotarget 2017 Mar 25. Epub 2017 Mar 25.
    Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
    Purpose: To investigate the safety, activity, and potential biomarkers of response to olaparib and carboplatin combination in sporadic triple negative breast cancer (TNBC).

    Experimental Design: Metastatic or recurrent TNBC patients with no germline BRCA mutation or with BRCAPro scores <10% and a negative family history were eligible. A 3+3 dose escalation tested olaparib capsules (400mg bid, days1-7) with carboplatin AUC3-5 on day1 or 2 every 21 days, ≤ 8 cycles, with olaparib 400mg bid maintenance. Read More

    Reoperation and readmission after clipping of an unruptured intracranial aneurysm: a National Surgical Quality Improvement Program analysis.
    J Neurosurg 2017 Apr 7:1-12. Epub 2017 Apr 7.
    Department of Neurosurgery, Cushing Neurosurgical Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    OBJECTIVE Although reoperation and readmission have been used as quality metrics, there are limited data evaluating the rate of, reasons for, and predictors of reoperation and readmission after microsurgical clipping of unruptured aneurysms. METHODS Adult patients who underwent craniotomy for clipping of an unruptured aneurysm electively were extracted from the prospective National Surgical Quality Improvement Program registry (2011-2014). Multivariable logistic regression and recursive partitioning analysis evaluated the independent predictors of nonroutine hospital discharge, unplanned 30-day reoperation, and readmission. Read More

    Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.
    Kidney Int 2017 Apr 3. Epub 2017 Apr 3.
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA. Electronic address:
    The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it facilitates sodium (re)absorption and proton secretion. The importance of NHE3 in the kidney for sodium chloride homeostasis, relative to the intestine, is unknown. Constitutive tubule-specific NHE3 knockout mice (NHE3(loxloxCre)) did not show significant differences compared to control mice in body weight, blood pH or bicarbonate and plasma sodium, potassium, or aldosterone levels. Read More

    Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Amyotrophic Lateral Sclerosis in a Patient Developing Carbon Dioxide Narcosis.
    Intern Med 2017 1;56(7):797-803. Epub 2017 Apr 1.
    Department of Internal Medicine, Osaka Red Cross Hospital, Japan.
    We report a rare case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with amyotrophic lateral sclerosis (ALS). A 69-year-old man was admitted to our hospital with sustained hyponatremia. Hyposmolality with elevated urinary osmolality and sodium excretion was observed, which indicated SIADH. Read More

    Hyponatraemia and congestive heart failure refractory to diuretic treatment. Utility of tolvaptan.
    Rev Clin Esp 2017 Mar 31. Epub 2017 Mar 31.
    Servicio de Cardiología, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
    Heart failure (HF) is currently one of the most significant healthcare problems in Spain and has a continuously increasing prevalence. Advances in our understanding of the various biological responses that promote cardiac remodelling and pulmonary venous congestion constitute the basis of current treatment. This article, prepared by members of the HF groups of the Spanish Society of Cardiology and the Spanish Society of Internal Medicine, discusses the current therapeutic strategies for patients with congestion refractory to diuretic treatment. Read More

    Incidence of Adverse Events During Peripheral Administration of Sodium Chloride 3.
    J Intensive Care Med 2017 Jan 1:885066617702590. Epub 2017 Jan 1.
    1 Department of Pharmacy, New York University Langone Medical Center, New York, NY, USA.
    Purpose: Traditionally, sodium chloride 3% has been administered via a central venous line (CVL) because of the perceived risk of infiltration and tissue injury due to its high osmolarity. In clinical practice, sodium chloride 3% is commonly administered through peripheral venous catheters (PVCs) given the necessity of timely administration. However, there is no published data on the safety of administering sodium chloride 3% through PVCs in the adult population. Read More

    Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan.
    J Infect Dev Ctries 2017 Mar 31;11(3):242-246. Epub 2017 Mar 31.
    Faculty of Medicine, Mutah University, Karak, Jordan.
    Introduction: The aim of this study was to describe the epidemiological patterns of Mediterranean spotted fever (MSF) as well as its treatment and outcomes in children in south Jordan.

    Methodology: A retrospective observational study was conducted from June 2013 to December 2015. Data regarding demographics, clinical presentation, laboratory findings, treatment, and outcomes were collected. Read More

    Therapeutic efficacy of nutritional support by percutaneous endoscopic gastrostomy in critically ill patients: A self-control clinical trial.
    Pak J Med Sci 2017 Jan-Feb;33(1):75-80
    Yi-Qun Hu Departments of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian, China.
    Background & Objective: Percutaneous endoscopic gastrostomy (PEG) is a procedure to provide enteral nutrition for critically ill patients. It is commonly used in clinical practice; however, the widespread use of PEG is controversial. Our objective was to evaluate the therapeutic effect of nutritional support by PEG in these critically ill patients. Read More

    Getting to the heart of hypopituitarism.
    Clin Med (Lond) 2017 Apr;17(2):140-142
    St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.
    A 53-year-old woman was diagnosed with hypopituitarism following an acute presentation with cardiac tamponade and hyponatraemia, having recently been investigated for a pericardial effusion. Secondary hypothyroidism is a rare cause of pericardial effusion and tamponade, but an important differential to consider. Management requires appropriate hormone replacement and, critically, a low threshold for commencing stress dose steroids. Read More

    Model for End-Stage Liver Disease-Sodium Score: The Evolution in the Prioritization of Liver Transplantation.
    Clin Liver Dis 2017 May;21(2):275-287
    Division of Gastroenterology, Hepatology and Nutrition, McGovern Medical School, University of Texas Health Science Center at Houston, 6400 Fannin Street, MSB 4.234, Houston, TX 77030, USA. Electronic address:
    The adoption of the model of end-stage liver disease (MELD) score as surrogate marker of liver disease severity has been the greatest change in liver allocation. Since its implementation, waiting time has lost significance. The MELD score calculation was later modified to reflect the contribution of hyponatremia in the estimation of mortality risk. Read More

    Prediction of diuretic response to tolvaptan by a simple, readily available spot urine Na/K ratio.
    PLoS One 2017 31;12(3):e0174649. Epub 2017 Mar 31.
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
    Background: Tolvaptan is vasopressin type 2 receptor antagonist that inhibits water reabsorption. It is used in combination with standard diuretics to treat ascites unresponsive to standard diuretic therapy or hyponatremia because of liver cirrhosis. This study evaluated the effectiveness and safety of tolvaptan in clinical practice and aimed to determine the factors related to its effectiveness. Read More

    Heterogeneous impact of body mass index on in-hospital mortality in acute heart failure syndromes: An analysis from the ATTEND Registry.
    Eur Heart J Acute Cardiovasc Care 2017 Mar 1:2048872617703061. Epub 2017 Mar 1.
    1 Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan.
    Background: Although the obesity paradox may vary depending upon clinical background factors such as age, gender, aetiology of heart failure and comorbidities, the reasons underlying the heterogeneous impact of body mass index (BMI) on in-hospital cardiac mortality under various conditions in patients with acute heart failure syndromes (AHFSs) remain unclear.

    Methods: Among 4617 hospitalised patients with AHFSs enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, the patient characteristics and in-hospital cardiac mortality rates in those with low BMI (BMI <25 kg/m(2), n = 3263) were compared to those with high BMI (BMI ⩾25 kg/m(2), n = 1354).

    Results: Compared to the high-BMI group, the low-BMI group was significantly older, less likely to be male and to have hypertensive or idiopathic dilated aetiologies and more likely to have valvular aetiologies and a history of prior hospitalisation for AHFS. Read More

    Confusion, Faciobrachial Dystonic Seizures, and Critical Hyponatremia in a Patient with Voltage-Gated Potassium Channel Encephalitis.
    Korean J Fam Med 2017 Mar 22;38(2):99-101. Epub 2017 Mar 22.
    Department of Internal Medicine, Redcliffe Hospital, Redcliffe, Queensland, Australia.
    Autoimmune limbic encephalitis is a rare cause of encephalitic disease. It is associated with various target antigens and is difficult to diagnose, and experience with its treatment is limited. This case report describes a 69-year-old man, who presented with life-threatening hyponatremia and confusion, following several months of gradually worsening faciobrachial dystonic seizures. Read More

    NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality.
    J Am Soc Nephrol 2017 Mar 30. Epub 2017 Mar 30.
    Due to the number of contributing authors, the affiliations are listed in the supplemental material.
    Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at P<5. Read More

    Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia: study protocol for a randomized controlled trial (SALSA trial).
    Trials 2017 Mar 29;18(1):147. Epub 2017 Mar 29.
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
    Background: Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered as a continuous infusion or a bolus injection has been found to date. Therefore, in the current study, we will evaluate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia. Read More

    Syndrome of inappropriate antidiuretic hormone secretion induced by the phytotherapy Harpagophytum procumbers: case report.
    J Bras Nefrol 2017 Mar;39(1):79-81
    Hospital Universitário Gaffrée e Guinle, Brazil.
    Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the inability of antidiuretic hormone (ADH) suppression, compromising the mechanisms of water excretion and urinary concentration. It manifests as hyponatremia and its symptoms, especially neurological. There are many causes that trigger such disease, notably: central nervous system disorders, malignant neoplasm, drugs and others. Read More

    Clinical characteristics of children with hemolytic uremic syndrome in Hangzhou, China.
    World J Pediatr 2017 Apr 28;13(2):183-185. Epub 2017 Mar 28.
    Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
    Background: Hemolytic uremic syndrome (HUS) is a main cause of acute renal failure in children. This study aimed to analyze the clinical characteristics of HUS.

    Methods: A retrospective analysis was performed in 46 children with sporadic HUS. Read More

    Treatment of Cirrhosis-Associated Hyponatremia with Midodrine and Octreotide.
    Front Med (Lausanne) 2017 14;4:17. Epub 2017 Mar 14.
    David Geffen School of Medicine at UCLA , Los Angeles, CA , USA.
    Background: Hyponatremia in the setting of cirrhosis is a common electrolyte disorder with few therapeutic options. The free water retention is due to non-osmotic vasopressin secretion resulting from the cirrhosis-associated splanchnic vasodilatation. Therefore, vasoconstrictive therapy may correct this electrolyte abnormality. Read More

    Hyponatremia secondary to acute urinary retention.
    Saudi J Kidney Dis Transpl 2017 Mar-Apr;28(2):392-395
    Department of General Medicine, St. Martha's Hospital, Bengaluru, Karnataka, India.
    Acute urinary retention is a rare cause of hyponatremia. Symptomatic acute hyponatremia is of grave medical concern and needs to be managed aggressively. In our two cases with acute urinary retention, a simple bladder catheterization and drainage of urine followed by conservative management resulted in complete resolution of symptoms and normalization of sodium levels. Read More

    Hypothyroidism and Hyponatremia: Rather Coincidence Than Causality.
    Thyroid 2017 Apr 19. Epub 2017 Apr 19.
    1 Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna, Austria .
    Background: Hypothyroidism is referred to be a rare but possible cause of hyponatremia. However, there is only poor evidence supporting this association. Since hyponatremia and hypothyroidism are both common conditions themselves, co-occurrence does not have to be causal. Read More

    Home-based drainage of refractory ascites by a permanent-tunneled peritoneal catheter can safely replace large-volume paracentesis.
    Eur J Gastroenterol Hepatol 2017 May;29(5):539-546
    aDepartment of Gastroenterology, Hepatology and Endocrinology bInstitute for Medical Microbiology and Hospital Epidemiology, Hannover cGerman Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Braunschweig, Germany dInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover.
    Background And Aim: Refractory ascites has a poor prognosis. Recurrent large-volume paracentesis is the current standard of care; however, it results in circulatory dysfunction and renal dysfunction, and hospitalization is commonly required. Transjugular intrahepatic portosystemic shunt placement is not an option in a substantial number of patients because of contraindications. Read More

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