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    1 OF 261

    Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood-brain barrier disruption in a murine model of osmotic demyelination syndrome.
    Glia 2017 Nov 23. Epub 2017 Nov 23.
    URPhyM - NARILIS, Université de Namur, Namur, Belgium.
    The osmotic demyelination syndrome (ODS) is a non-primary inflammatory disorder of the central nervous system myelin that is often associated with a precipitous rise of serum sodium concentration. To investigate the physiopathology of ODS in vivo, we generated a novel murine model based on the abrupt correction of chronic hyponatremia. Accordingly, ODS mice developed impairments in brainstem auditory evoked potentials and in grip strength. Read More

    Association between borderline dysnatremia and mortality insight into a new data mining approach.
    BMC Med Inform Decis Mak 2017 Nov 22;17(1):152. Epub 2017 Nov 22.
    Division of Geriatrics, Hôpital Européen G. Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Background: Even small variations of serum sodium concentration may be associated with mortality. Our objective was to confirm the impact of borderline dysnatremia for patients admitted to hospital on in-hospital mortality using real life care data from our electronic health record (EHR) and a phenome-wide association analysis (PheWAS).

    Methods: Retrospective observational study based on patient data admitted to Hôpital Européen George Pompidou, between 01/01/2008 and 31/06/2014; including 45,834 patients with serum sodium determinations on admission. Read More

    The use of crystalloids in traumatic brain injury.
    Anaesthesiol Intensive Ther 2017 Nov 22. Epub 2017 Nov 22.
    Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Poland.
    Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypo- and hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. Read More

    Association of serum sodium and risk of all-cause mortality in patients with chronic kidney disease: A meta-analysis and sysematic review.
    Sci Rep 2017 Nov 21;7(1):15949. Epub 2017 Nov 21.
    Department of Nephrology, The First Hospital of Jilin University, 130021, Changchun, China.
    Studies on the association of dysnatraemia with all-cause mortality risk in chronic kidney disease (CKD) patients have yielded inconsistent results. This meta-analysis aimed to evaluate the association of hyponatremia or hypernatremia with all-cause mortality risk in CKD patients. An electronic literature search was performed in Web of Science, Pubmed and Embase databases from inception to March 2017 for available observational studies evaluating the association of dysnatraemia with all-cause mortality risk in CKD patients. Read More

    The impact of aneurysm location on incidence and etiology of hyponatremia following subarachnoid hemorrhage.
    World Neurosurg 2017 Nov 18. Epub 2017 Nov 18.
    Background: Hyponatremia is the most common electrolyte abnormality in patients with aneurysmal subarachnoid hemorrhage (aSAH). The syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt wasting (CSW) are the most common etiologies. Whether or not the location of the ruptured aneurysm is associated with the etiology of hyponatremia is unknown. Read More

    [Perioperative Intravenous Fluid Therapy in Children].
    Anasthesiol Intensivmed Notfallmed Schmerzther 2017 Nov 20;52(11-12):799-804. Epub 2017 Nov 20.
    The objective of this consensus-based S1 Guideline for perioperative fluid therapy in children is to maintain or re-establish the child's homeostasis. Therefore, the perioperative fasting times should be as short as possible to prevent patient discomfort, dehydration, and ketoacidosis. For the intraoperative background infusion a physiologically composed balanced isotonic electrolyte solution (BS) with 1 - 2. Read More

    Mycoplasma pneumoniae-associated encephalitis complicated by cerebral salt wasting syndrome.
    Clin Case Rep 2017 Nov 26;5(11):1830-1833. Epub 2017 Sep 26.
    Department of PediatricsCathay General HospitalTaipeiTaiwan.
    Cerebral salt wasting syndrome can occur in children with encephalitis. Clinicians should be aware of hyponatremia in patients who develop polyuria with the signs of dehydration and deteriorated consciousness. Furthermore, patients who present with status epilepticus or who are suspected to have high intracranial pressure may have an increased risk of cerebral salt wasting syndrome. Read More

    Amiodarone-Induced Hyponatremia Masked by Tolvaptan in a Patient with an Implantable Left Ventricular Assist Device.
    Int Heart J 2017 Nov 17. Epub 2017 Nov 17.
    Second Department of Internal Medicine, University of Toyama.
    A 43-year-old man was referred to our hospital in June 2014 because of severe heart failure. He was diagnosed with familial dilated cardiomyopathy and was administered oral tolvaptan and amiodarone for atrial and ventricular tachycardia. Since up-titration of carvedilol had failed and he was dependent on dobutamine, a left ventricular assist device (LVAD) was implanted. Read More

    Sodium variability is associated with increased mortality in severe burn injury.
    Burns Trauma 2017 6;5:34. Epub 2017 Nov 6.
    Department of Surgery, Division of Burn Surgery, University of California Davis, 2425 Stockton Blvd. Suite 718, Sacramento, CA 95817 USA.
    Background: Dysnatremias are associated with increased mortality in critically ill patients. Hypernatremia in burn patients is also associated with poor survival. Based on these findings, we hypothesized that high plasma sodium variability is a marker for increased mortality in severely burn-injured patients. Read More

    A Prospective Randomized Study Comparing Unipolar Versus Bipolar Hysteroscopic Myomectomy in Infertile Women.
    J Hum Reprod Sci 2017 Jul-Sep;10(3):185-193
    Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
    Study Objective: To compare the operative and reproductive outcome of hysteroscopic myomectomy using unipolar resectoscope versus bipolar resectoscope in patients with infertility and menorrhagia.

    Design: Randomized, prospective, parallel, comparative, single-blinded study.

    Design Classification: Canadian Task Force classification I. Read More

    Localized Pontine Uptake in Fluorine-18-Fuorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Case of Hyponatremia: A Case Report and Review of Literature.
    Indian J Nucl Med 2017 Oct-Dec;32(4):333-335
    Department of Nuclear Medicine, Apollo Hospitals, Chennai, Tamil Nadu, India.
    A rare acquired demyelinating lesion of the pons central pontine myelinolysis (CPM) typically occurs after rapid correction of hyponatremia. There is disruption of blood-brain barrier due to osmotic stress allowing access for inflammatory mediators in extravascular brain tissue, which most likely attracts glial cells of the brain, attracts macrophages, and activates astrocytes. We present a case of female with a known history of inflammatory bowel disease who presented with altered sensorium and hyponatremia. Read More

    A case report of hyponatremia after surgery for Conn's adenoma.
    J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317740240
    1 Department of Medical Sciences, University of Trieste, Italy.
    Primary aldosteronism (PA), also known as Conn's syndrome, is a frequent cause of secondary hypertension. If PA is due to a documented unilateral adrenal adenoma, adrenalectomy is the treatment of choice. Endocrine Society guidelines suggest monitoring potassium after adrenalectomy, while there is no mention of sodium disorders after surgery. Read More

    Central Pontine Myelinolysis After Living-Donor Liver Transplant: A Report of 2 Cases.
    Exp Clin Transplant 2017 Nov 15. Epub 2017 Nov 15.
    From the Department of Nursing, Changhua Christian Hospital, Changhua, Taiwan.
    Here, we present 2 patients who developed central pontine myelinolysis after living-donor liver transplant. Both patients had abnormal sodium level before living-donor liver transplant. Patient 1 presented with severe hyponatremia on admission. Read More

    Electrolytes imbalance caused by amikacin in patients receiving multi drug resistance- tuberculosis treatment at Hazara region Kpk, Pakistan.
    Tuberk Toraks 2017 Sep;65(3):193-201
    Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan.
    Introduction: Multi drug resistance-tuberculosis (MDR-TB) is considered amongst one of the fatal medical and public health issue. Greater frequency of adverse reactions has been observed using 2nd line antituberculosis drugs, which rises the rate of morbidity. Hypokalemia and hyponatremia are common in patients receiving MDR-TB treatment. Read More

    Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
    J Crit Care 2017 Nov 8. Epub 2017 Nov 8.
    Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. Electronic address:
    Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Read More

    Decompensated Cirrhosis and Fluid Resuscitation.
    Surg Clin North Am 2017 Dec 5;97(6):1419-1424. Epub 2017 Oct 5.
    Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:
    The critically ill patient with decompensated cirrhosis has a unique physiology and alterations in albumin that need to be understood to properly resuscitate them and minimize morbidity and mortality. Little data exist on specific resuscitation of the patient with cirrhosis compared with those patients without liver disease. The effectiveness of albumin administration compared with saline administration in common settings, such as large-volume paracentesis, can be extrapolated to the care of the general surgical patient but further studies in this area are warranted. Read More

    Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study.
    Am J Nephrol 2017 Nov 7;46(5):417-426. Epub 2017 Nov 7.
    Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
    Background: Tolvaptan increases free water clearance (aquaresis) and thereby improves hyponatremia. Although hyponatremia on admission is common in patients with congestive heart failure (CHF), little is known regarding the response to tolvaptan in those who also have chronic kidney disease (CKD) with or without hyponatremia. The aim of this subanalysis was to investigate the differences in treatment response between normo- and hyponatremia patients with CHF and CKD stages G3b-5. Read More

    Extracellular volume depletion and resultant hypotonic hyponatremia: A novel translational approach.
    Math Biosci 2017 Nov 10;295:62-66. Epub 2017 Nov 10.
    Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:
    Although several methods currently exist to determine that a person is hypovolemic, it often remains very challenging to accurately estimate the effective circulating volume or amount of intravascular volume depletion in a non-controlled setting. This depletion of intravascular volume can have many causes and is frequently accompanied by hypotonic hyponatremia as a result of hypovolemia-induced release of arginine vasopressin (AVP) from the posterior pituitary gland. Here, we derive a novel, comprehensible equation that provides a theoretical insight into the complex interrelationship between the degree of isotonic volume depletion and the resultant change in plasma sodium concentration. Read More

    High aldosterone and cortisol levels in salt wasting congenital adrenal hyperplasia: a clinical conundrum.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    Background: Salt wasting syndrome (hyponatremia, hyperkalemia, dehydration, metabolic acidosis) in early infancy could be caused by either mineralocorticoid deficiency as in congenital adrenal hyperplasia (CAH) and adrenal insufficiency or mineralocorticoid resistance as in pseudohypoaldosteronism (PHA). In salt wasting CAH, serum aldosterone and cortisol levels are expected to be low. Cross reactivity between high levels of adrenal steroid precursors and aldosterone has recently been reported resulting in elevated aldosterone levels in CAH, leading to difficulty in differentiating between CAH and PHA. Read More

    [Syndrome of inappropriate antidiuresis and the current management of hyponatremia].
    Vnitr Lek 2017 ;63(9):593-597
    Hyponatremia defined as serum sodium lower than 135 mmol/L is the most common electrolyte abnormality in outpatients and also in hospitalized patients. It has been documented that hyponatremia is associated with significantly higher morbidity, mortality and longer hospitalization stay. Hyponatremia is manifested by variety of symptoms, from mild up to life threatening conditions. Read More

    Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
    Swiss Med Wkly 2017 Nov 9;147:w14514. Epub 2017 Nov 9.
    Endocrinology, Diabetology and Metabolism, University Hospital Basel, Switzerland / Department of Clinical Research, University Hospital Basel, Switzerland.
    Primary polydipsia (PP) has been defined as excessive intake of fluids. However, the pathogenesis of PP remains unexplored. Different theories include a dysfunction in the thirst mechanism, involvement of the hippocampus, stress-reducing behaviour and lesion occurrences in specific areas of the brain. Read More

    In-patient Tolvaptan use in SIADH: care audit, therapy observation and outcome analysis.
    BMC Endocr Disord 2017 Nov 6;17(1):69. Epub 2017 Nov 6.
    Department of Endocrinology & Diabetes, Queen Alexandra Hospital Portsmouth, Portsmouth, PO6 3LY, UK.
    Background: Indications for use of tolvaptan in SIADH-associated hyponatraemia remain controversial. We audited our local guidelines for Tolvaptan use in this situation to review treatment implications including drug safety, hospital admission episode analysis (episodes of liver toxicity, CNS myelinolysis, sodium-related re-admission rates), morbidity; mortality and underlying aetiologies.

    Methods: We report a retrospective case series analysis of on-going treatment outcomes (case-note review) for 31 patients (age 73. Read More

    Association between postoperative hyponatremia and renal prognosis in major urologic surgery.
    Oncotarget 2017 Oct 18;8(45):79935-79947. Epub 2017 Aug 18.
    Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
    Recent evidence for the clinical significance of postoperative hyponatremia after urologic surgeries remains scarce. We examined the incidence, risk factors, and outcomes of electrolyte imbalance in urologic surgery. Patients with newly developed hyponatremia, defined as a sodium level lower than 135 mEq/L within 7 days after surgery, were included in our study group. Read More

    Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.
    Oncotarget 2017 Oct 25;8(45):79175-79187. Epub 2017 Mar 25.
    Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
    Purpose: To investigate the safety, activity, and potential biomarkers of response to olaparib and carboplatin combination in sporadic triple negative breast cancer (TNBC). EXPERIMENTAL DESIGN: Metastatic or recurrent TNBC patients with no germline BRCA mutation or with BRCAPro scores <10% and a negative family history were eligible. A 3+3 dose escalation tested olaparib capsules (400mg bid, days1-7) with carboplatin AUC3-5 on day1 or 2 every 21 days, ≤ 8 cycles, with olaparib 400mg bid maintenance. Read More

    N-terminal pro-B-type Natriuretic Peptide in three different mechanisms of dysnatremia onset after a child's craniopharyngioma surgery.
    • Authors:
    Neuro Endocrinol Lett 2017 Oct 6;38(5):321-324. Epub 2017 Oct 6.
    Craniopharyngioma, due to its sellar location, can be perioperatively complicated by different types of dysnatremia. We present a rare postoperative onset of a combination of three different mechanisms of dysnatremia with N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) and renal function parameters in a boy with a good outcome after craniopharyngioma surgery: 1/ Central diabetes insipidus (CDI) onset immediately after the operation, hypernatremia with peak serum sodium (SNa) 158 mmol/l) caused by free water polyuria (electrolyte-free water clearance, EWC 0.104 ml/s), NT-proBNP 350 pg/ml; 2/ cerebral salt wasting (CSW) onset on day 7, hyponatremia (SNa 128 mmol/l) with hypoosmolality (measured serum osmolality, SOsm 265 mmol/kg) caused by natriuresis (sodium - daily output 605 mmol/day, fractional excretion 0. Read More

    Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study.
    Respir Res 2017 Nov 3;18(1):184. Epub 2017 Nov 3.
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
    Background: Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not clear.

    Method: We determined copeptin and NT-proBNP concentrations at hospital admission in 314 patients with acute dyspnea who were categorized by diagnosis. Survival was registered after a median follow-up of 816 days, and the prognostic and diagnostic properties of copeptin and NT-proBNP were analyzed in acute HF (n = 143) and AECOPD (n = 84) separately. Read More

    Is Central Pontine Myelinolysis Reversible?
    WMJ 2016 12;115(6):326-8
    Central pontine myelinolysis (CPM) is a rare phenomenon that causes significant morbidity and mortality. Active therapeutic interventions for CPM can have a positive impact on recovery and overall prognosis. This case represents a 34-year-old white man with a chronic history of alcohol abuse who had Parkinsonian symptoms 13 days after rapid correction of his serum sodium in the hospital. Read More

    Primary hypothyroidism and isolated ACTH deficiency induced by nivolumab therapy: Case report and review.
    Medicine (Baltimore) 2017 Nov;96(44):e8426
    aDepartment of Endocrinology, Huashan Hospital North bDepartment of Endocrinology, Huashan Hospital, Fudan University, Shanghai, China.
    Rationale: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system.

    Patient Concerns: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Read More

    Effect of Menstrual Cycle on Acute Intermittent Porphyria.
    Child Neurol Open 2017 Jan-Dec;4:2329048X17736170. Epub 2017 Oct 18.
    Department of Clinical Medicine-Hematology, Universidade Federal de Pernambuco, Recife, Brazil.
    A 16-year-old female who was attended as an outpatient reported localized, acute abdominal pain with vomiting, symmetrical motor weakness, and burning sensation in both arms and legs. Her medical history showed irrational behavior, repeated admissions at the emergency units of many other reference hospitals, where she had been investigated for celiac disease and treated with analgesics for pain events. Her clinical condition remained unchanged despite the use of many oral analgesics. Read More

    Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review.
    Wellcome Open Res 2017 28;2:66. Epub 2017 Sep 28.
    KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya.
    Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral rehydration solution (ORS) for SAM), which has lower sodium (45mmols/l) and higher potassium (40mmols/l) content than old WHO ORS. The composition of ReSoMal was designed specifically to address theoretical risks of sodium overload and potential under-treatment of severe hypokalaemia with rehydration using standard ORS. Read More

    The prevalence and mortality of hyponatremia is seriously underestimated in Chinese general medical patients: an observational retrospective study.
    BMC Nephrol 2017 Oct 31;18(1):328. Epub 2017 Oct 31.
    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Shuaifuyan, Wangfujing St, Beijing, 100730, China.
    Background: Hyponatremia (serum sodium concentration < 135 mmol/L) is the most common electrolyte abnormality and is a predictor of the mortality of hospitalized patients in Western countries. However, hyponatremia data are lacking in Asian countries. Here we evaluate the epidemiology and mortality of hyponatremia in general medical hospitalized patients in China. Read More

    Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment.
    J Clin Med 2017 Oct 31;6(11). Epub 2017 Oct 31.
    Department of Endocrinology and Metabolism, International University of Health and Welfare Hospital, Nasushiobara 329-2763, Tochigi, Japan.
    Exaggerated release of arginine vasopressin (AVP) is profoundly involved in impaired water excretion and related hyponatremia. Such disorders underlie syndromes of inappropriate secretion of antidiuretic hormone (SIADH) and edematous diseases, such as congestive heart failure and decompensated liver cirrhosis. All the causes are fundamentally from non-endocrine diseases. Read More

    Pathophysiology of Hyponatremia in Children.
    Front Pediatr 2017 16;5:213. Epub 2017 Oct 16.
    Second Faculty of Medicine, Department of Pediatrics, Motol University Hospital, Charles University in Prague, Praha, Czechia.
    Hyponatremia is a common electrolyte disorder in children. It is generally defined as plasma sodium of less than 135 mmol/l. Sodium homeostasis is essential for maintaining intravascular volume and is tightly linked to water balance. Read More

    Hyponatraemia and its prognosis in acute heart failure is related to right ventricular dysfunction.
    Heart 2017 Oct 27. Epub 2017 Oct 27.
    Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
    Objectives: Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. Read More

    Cerebral Salt-Wasting Syndrome: Diagnosis by Urine Sodium Excretion.
    Am J Med Sci 2017 Oct 20;354(4):350-354. Epub 2017 May 20.
    Department of Medicine, University of California San Francisco, San Francisco, California.
    Background: Cerebral salt-wasting syndrome (CSWS) was initially described over 60 years ago in hyponatremic patients with a cerebral lesion. However, the diagnostic criteria for CSWS have not been fully established. Thus, when hyponatremia is observed in patients with CSWS, they may be misdiagnosed as having the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Read More

    Effects of eslicarbazepine acetate on lipid profile and sodium levels in patients with epilepsy.
    Seizure 2017 Oct 3;53:1-3. Epub 2017 Oct 3.
    Department of Science of Health, School of Medicine and Surgery, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
    Purpose: Several studies have demonstrated that treatment with enzyme-inducing antiepileptic drugs is associated with increased serum lipid levels. Eslicarbazepine acetate (ESL) is a novel antiepileptic drug specifically designed with the objective to identify carbamazepine and oxcarbazepine analogues with favorable pharmacodynamic and pharmacokinetic profiles. The present study aimed to assess the changes in lipid profile and sodium levels in patients with epilepsy taking ESL as adjunctive therapy. Read More

    Proposing a validated clinical app predicting hospitalization cost for extracranial-intracranial bypass surgery.
    PLoS One 2017 27;12(10):e0186758. Epub 2017 Oct 27.
    Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Los Angeles, United States of America.
    Object: United States healthcare reforms are focused on curtailing rising expenditures. In neurosurgical domain, limited or no data exists identifying potential modifiable targets associated with high-hospitalization cost for cerebrovascular procedures such as extracranial-intracranial (ECIC) bypass. Our study objective was to develop a predictive model of initial cost for patients undergoing bypass surgery. Read More

    Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis.
    Aust Vet J 2017 Nov;95(11):444-447
    Veterinary Teaching Hospital "Mario Modenato", Department of Veterinary Sciences, University of Pisa, via Livornese Lato monte, San Piero a Grado, 56122 Pisa, Italy.
    Objective: To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice.

    Design: Retrospective study between January 2010 and December 2013.

    Methods: The diagnosis of AP was based on clinical signs and an abnormal SNAP® cPL™ test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Read More

    A practical method for prevention of readmission for symptomatic hyponatremia following transsphenoidal surgery.
    Pituitary 2017 Oct 26. Epub 2017 Oct 26.
    Pituitary/Neuroendocrine Center, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA, USA.
    Introduction: Patients undergoing transsphenoidal pituitary surgery (TSS) are at risk for several serious complications, including the syndrome of inappropriate antidiuretic hormone and subsequent hyponatremia.

    Objective: In this study, we examined the effect of 1 week of post-discharge fluid restriction to 1.0 L daily on rates of post-operative readmission for hyponatremia. Read More

    Unusual Complication of Multidrug Resistant Tuberculosis.
    Case Rep Nephrol 2017 18;2017:6835813. Epub 2017 Sep 18.
    Division of Medicine, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai 400 012, India.
    Introduction: Capreomycin is a second-line drug often used for multidrug-resistant tuberculosis which can result in nephrotoxic effects similar to other aminoglycosides. We describe a case of capreomycin induced Bartter-like syndrome with hypocalcemic tetany.

    Case Report: 23-year-old female patient presented with carpopedal spasms and tingling sensations in hands. Read More

    Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding.
    Gastroenterol Res Pract 2017 17;2017:7610374. Epub 2017 Sep 17.
    Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
    Objectives: Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. Read More

    A non-randomized, open-label, single-arm, Phase 2 study of emibetuzumab in Asian patients with MET diagnostic positive, advanced gastric cancer.
    Cancer Chemother Pharmacol 2017 Dec 25;80(6):1197-1207. Epub 2017 Oct 25.
    National Cancer Center Hospital East, 5-1, Kashiwanoha 6-chome, Kashiwa, Chiba, 277-8577, Japan.
    Purpose: Mesenchymal-epithelial transition factor (MET) is expressed in gastric cancer and associated with poor clinical outcomes. We assessed activity, safety, and pharmacokinetics of emibetuzumab, a bivalent monoclonal anti-MET antibody that blocks ligand-dependent and ligand-independent MET signaling.

    Methods: This non-randomized, single-arm, Phase 2 study enrolled Asian patients with MET diagnostic positive advanced gastric adenocarcinoma. Read More

    A phase I study of the SRC kinase inhibitor dasatinib with trastuzumab and paclitaxel as first line therapy for patients with HER2-overexpressing advanced breast cancer. GEICAM/2010-04 study.
    Oncotarget 2017 Sep 14;8(42):73144-73153. Epub 2017 Apr 14.
    Department of Medical Oncology, Fundación Onkologikoa, Donostia, Gipuzkoa, Spain.
    The anti-HER2 antibody trastuzumab have shown clinical activity in combination with chemotherapy in different breast cancer settings. However, most of patients treated with this antibody progress after a period of treatment. Activation of the kinase SRC has been linked with resistance to trastuzumab in several preclinical studies. Read More

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