16,206 results match your criteria Hyponatremia


Recovery in Stroke Patients Treated With Fluoxetine Versus Placebo: A Pooled Analysis of 7165 Patients.

Neurologist 2022 Jul 1. Epub 2022 Jul 1.

Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Stroke is a major cause of disability and death. Stroke recovery outcomes range from functional impairment to disability. This study was designed to compare the recovery results of stroke patients treated with fluoxetine to those treated with placebo. Read More

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A Case of Leishmaniasis Infantum Kala-Azar in an Immunocompetent 49-Year-Old Man.

Cureus 2022 May 29;14(5):e25442. Epub 2022 May 29.

Department of Internal Medicine, NCH Healthcare System, Naples, USA.

An immunocompetent 45-year-old Cuban-American man presented with worsening knee pain and swelling despite antibiotic therapy. On physical examination, the patient was ill-appearing, cachectic, with a protuberant abdomen and massive splenomegaly. In addition, he had a 10 cm area of peripheral hyperemia with central necrosis in the medial left knee that was non-tender and non-fluctuant. Read More

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Hypernatremia is associated with poor long-term neurological outcomes in out-of-hospital cardiac arrest survivors.

Am J Emerg Med 2022 Jun 20;59:30-36. Epub 2022 Jun 20.

Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.

Background: Brain oedema after cardiac arrest is strongly associated with poor neurological outcomes. Excessive sodium supplementation may increase serum osmolarity and facilitate brain oedema development in cardiac arrest survivors. We aimed to investigate the association of serum sodium levels with long-term neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors. Read More

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Diagnosis and Management of Central Diabetes Insipidus in Adults.

J Clin Endocrinol Metab 2022 Jun 30. Epub 2022 Jun 30.

Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland.

Central diabetes insipidus (CDI) is a clinical syndrome which results from loss or impaired function of vasopressinergic neurones in the hypothalamus/posterior pituitary, resulting in impaired synthesis and/or secretion of arginine vasopressin (AVP). AVP deficiency leads to the inability to concentrate urine and excessive renal water losses, resulting in a clinical syndrome of hypotonic polyuria with compensatory thirst. CDI is caused by diverse aetiologies, although it typically develops due to neoplastic, traumatic or autoimmune destruction of AVP synthesizing/secreting neurones. Read More

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Machine-learning Models Predict 30-Day Mortality, Cardiovascular Complications, and Respiratory Complications After Aseptic Revision Total Joint Arthroplasty.

Clin Orthop Relat Res 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopaedic Surgery, Bone and Joint Sports Medicine Center, Naval Medical Center Portsmouth, Portsmouth, VA, USA.

Background: Aseptic revision THA and TKA are associated with an increased risk of adverse outcomes compared with primary THA and TKA. Understanding the risk profiles for patients undergoing aseptic revision THA or TKA may provide an opportunity to decrease the risk of postsurgical complications. There are risk stratification tools for postoperative complications after aseptic revision TKA or THA; however, current tools only include nonmodifiable risk factors, such as medical comorbidities, and do not include modifiable risk factors. Read More

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[Clinical features and influencing factors of long-term prognosis in patients with tuberculous meningitis].

Zhonghua Nei Ke Za Zhi 2022 Jul;61(7):764-770

State Key Laboratory of Complex Severe and Rare Diseases, Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Centre for Tuberculosis Research, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the clinical features and influencing factors of long-term prognosis of tuberculous meningitis(TBM), and to provide a recommendation for treatment and early intervention of TBM. Clinical data of TBM patients were retrospectively collected at Peking Union Medical College Hospital from January 2014 to December 2021. Patients who were followed-up more than one year were divided into two groups according to modified Rankin Scale (mRS). Read More

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Refractory Hypernatremia and Osmotic Demyelination Syndrome After Liver Transplantation: A Case Report.

Transplant Proc 2022 Jun 24. Epub 2022 Jun 24.

Liver Transplant Division, Federal District Institute of Cardiology, Brasília, Brazil.

Osmotic demyelination syndrome is an uncommon neurologic condition, characterized by noninflammatory demyelination involving the pons and other areas of the central nervous system. As chronic hyponatremia is frequently associated with cirrhosis, patients undergoing liver transplantation are at an increased risk for developing this condition. We report the case of a patient who developed refractory hypernatremia and osmotic demyelination syndrome after liver transplantation. Read More

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Association of proton pump inhibitor use and significant hyponatremia-a US population-based case-control study.

Proc (Bayl Univ Med Cent) 2022 22;35(4):434-436. Epub 2022 Apr 22.

Division of Nephrology, Department of Medicine, University of South Alabama, Mobile, Alabama.

Hyponatremia is the most common electrolyte abnormality encountered in clinical practice. Several medications are associated with hyponatremia. Proton pump inhibitors were reported to cause hyponatremia in one large Swedish population-based study and small observational studies or case reports. Read More

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Safety of linezolid, rifampicin, and clindamycin combination therapy in patients with prosthetic joint infection.

Drug Discov Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, Tokyo, Japan.

We investigated adverse events in patients with prosthetic joint infections receiving combination therapy with linezolid, rifampicin, and clindamycin for ≥ 7 days. Twenty-two patients were evaluated. The combination therapy was administered for 15. Read More

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Neuroleptic malignant syndrome in a case of extra-pontine myelinolysis: On the horns of dilemma.

Drug Discov Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of Medicine, All India Institute of Medical Sciences, Delhi, India.

Osmotic demyelination syndrome (ODS) and neuroleptic malignant syndrome (NMS) lead to severe neurological sequalae. Though currently thought to be different syndromes, literature suggests a relation between the two. We present the case of a 45-year-old male who was found to have chronic severe hyponatremia and underwent rapid correction of sodium and developed parkinsonism features. Read More

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Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France.

Pathogens 2022 Jun 17;11(6). Epub 2022 Jun 17.

Centre de Recherche Saint-Antoine, CRSA, Inserm, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Sorbonne Université, 75012 Paris, France.

Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. Read More

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Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports.

Neuropsychopharmacol Rep 2022 Jun 22. Epub 2022 Jun 22.

Department of Psychiatry, Dokkyo Medical University, School of Medicine, Shimotsuga-gun, Japan.

Background: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain.

Case Presentation: The patients were an 83-year-old Japanese male and a 71-year-old Japanese female. Several years earlier, they complained of pain. Read More

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Symptomatic absorption of normal saline during transurethral resection of the prostate: a case report.

JA Clin Rep 2022 Jun 21;8(1):43. Epub 2022 Jun 21.

Department of Anesthesiology, Osaka City University Graduate School of Medicine, 1-5-7 Asahimachi, Abeno-ku, Osaka, 545-8586, Japan.

Background: Transurethral resection of the prostate (TUR-P) could incidentally cause hyponatremia, known as TUR syndrome due to intravascular absorption of non-electrolytic irrigation fluid. Recently, normal saline has been used as an irrigation fluid in a new system named TURis (TUR in saline) to prevent TUR syndrome. However, rapid massive absorption of normal saline can also cause other systemic adverse events. Read More

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Metagenomic next-generation sequencing for the diagnosis of Chlamydia psittaci pneumonia.

Clin Respir J 2022 Jun 20. Epub 2022 Jun 20.

Department of Pulmonary and Critical Care Medicine, Yueyang Central Hospital, Yueyang, Hunan, China.

The aim of this study was to investigate the clinical characteristics of Chlamydia psittaci pneumonia and evaluate the diagnostic value of Metagenomic Next-Generation Sequencing (mNGS). A total of 44 patients diagnosed with Chlamydia psittaci pneumonia using mNGS were retrospectively analysed. The demographic and clinical features, laboratory data, imaging findings and clinical outcomes were collected. Read More

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Non-ST-Segment Elevation Myocardial Infarction Shortly After Starting Steroid Replacement Therapy in a Patient With Adrenal Insufficiency.

Cureus 2022 May 16;14(5):e25061. Epub 2022 May 16.

Clinical Medicine, QU Health, Qatar University, Doha, QAT.

Adrenal insufficiency is a rare disorder that results from etiological factors affecting either the hypothalamic-pituitary axis or the adrenal gland itself. Studies have associated an inherently increased risk of cardiovascular events with this condition. It is treated with exogenous steroid supplementation. Read More

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Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology.

Intern Med J 2022 Jun 19. Epub 2022 Jun 19.

Neurological Intervention & Imaging Service of WA (NIISwa), Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia.

Background: Osmotic demyelination syndrome (ODS) is non inflammatory demyelination in response to an osmotic challenge. It can be pontine or extrapontine in presentation AIM: Retrospective review of cases involving ODS and define the spectrum of causes, risk factors, clinical and radiological presentations, and functional outcomes.

Results: The study utilized data from 15 patients with a mean age of 53. Read More

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The association of hyponatremia and clinical outcomes in patients with acute myocardial infarction: a cross-sectional study.

BMC Cardiovasc Disord 2022 Jun 18;22(1):276. Epub 2022 Jun 18.

Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.

Introduction: Hyponatremia is a common electrolyte abnormality that has been associated with poor outcomes in several conditions including acute myocardial infarction (AMI). However, those studies were performed in the era before percutaneous coronary intervention (PCI), focused mostly on ST-elevation myocardial infarction (STEMI), and sodium levels up to 72 h of admission. The purpose of this study was to identify the association between hyponatremia and clinical outcomes in patients with acute myocardial infarction. Read More

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Syndrome of inappropriate secretion of antidiuretic hormone as an initial sign of primary central nervous system lymphomas in the hypothalamus.

Acta Neurol Belg 2022 Jun 18. Epub 2022 Jun 18.

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Primary central nervous system lymphoma (PCNSL) rarely originates in the hypothalamus. Hypothalamic PCNSL can present with various symptoms specific to dysfunction of the hypothalamus, including consciousness disturbance, cognitive impairment, hypopituitarism, and diabetes insipidus (DI). However, it remains unclear whether syndrome of inappropriate secretion of antidiuretic hormone (SIADH) can present as an initial sign of hypothalamic PCNSL. Read More

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Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion.

Sci Rep 2022 Jun 17;12(1):10266. Epub 2022 Jun 17.

Endocrinology and Nutrition Department, San Juan University Hospital, Alicante, Spain.

The aim of this work is to examine our experience in the use of urea in patients with SIADH. Observational retrospective analysis of 48 patients with SIADH that have been treated with urea in a third-level hospital. Pre-post analysis of serum sodium levels. Read More

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Vasopressin-Induced Hyponatremia in Infants Following Cardiovascular Surgery.

Ann Pharmacother 2022 Jun 17:10600280221103576. Epub 2022 Jun 17.

Department of Pharmacy: Clinical and Administrative Sciences, The University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.

Background: Vasopressin is increasingly used in infants following cardiac surgery. Hyponatremia is a noted adverse event, but incidence and risk factors remain undefined.

Objective: The primary objective was to identify the incidence of vasopressin-induced hyponatremia. Read More

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Effects of sodium-glucose cotransporter 2 inhibitors and aldosterone antagonists, in addition to renin-angiotensin system antagonists on major adverse kidney outcomes in patients with type 2 diabetes and chronic kidney disease: a systematic review and network meta-analysis.

Diabetes Obes Metab 2022 Jun 16. Epub 2022 Jun 16.

Department of Endocrinology and Metabolism, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning Province, P.R.China.

Background: This study aimed to compare the efficacy of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, non-steroidal mineralocorticoid receptor antagonist (MRA), selective aldosterone antagonist, and non-selective aldosterone antagonist on top of renin-angiotensin system (RAS) blockade in reducing kidney-specific composite events, cardiovascular outcomes, and other events of special interest in participants with type 2 diabetes (T2D) and chronic kidney disease (CKD).

Methods: PubMed, EMBASE, and CENTRAL were searched for studies published up to January 20, 2022. Randomized clinical trials enrolling participants with T2D and CKD were included, for which SGLT-2 inhibitors, non-steroidal MRA, selective aldosterone antagonist, and non-selsective aldosterone antagonists were compared with either each other, or placebo or no treatment. Read More

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Electrolyte Abnormalities Associated With the Use of Atezolizumab - A Systematic Review.

J Community Hosp Intern Med Perspect 2022 12;12(2):35-44. Epub 2022 Apr 12.

Department of Internal Medicine, McLaren Flint Michigan State University, Flint, MI, USA.

Background And Objectives: In recent years, immune-checkpoint inhibitors (ICIs) particularly atezolizumab is on the rise in treating advanced malignancies. With its increased clinical use, various electrolyte abnormalities have been reported in the literature. In this review, we have addressed the question of significant electrolyte abnormalities associated with atezolizumab. Read More

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Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone Associated With Varicella Infection In Children.

Pediatr Infect Dis J 2022 Jun 6. Epub 2022 Jun 6.

From the Department of Pediatric Infectious Diseases, Hangzhou Children's Hospital, Hangzhou, China.

A 9-year-old girl with remarkable hyponatremia was diagnosed with SIADH that was likely secondary to varicella. Under appropriate treatment, her serum sodium returned to the normal level. There was no evidence of hyponatremia at a 3-month follow-up. Read More

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Hyponatremia is a Powerful Predictor of Poor Prognosis in Left Ventricular Assist Device Patients.

ASAIO J 2022 Jun 13. Epub 2022 Jun 13.

From the Department of Medicine, Division of Cardiology, Northwestern University, Chicago, Illinois.

Serum sodium is an established prognostic marker in heart failure (HF) patients and is associated with an increased risk of morbidity and mortality. We sought to study the prognostic value of serum sodium in left ventricular assist device (LVAD) patients and whether hyponatremia reflects worsening HF or an alternative mechanism. We identified HF patients that underwent LVAD implantation between 2008 and 2019. Read More

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Indications for ordering thyroid-stimulating hormone in noncritically ill adult inpatients-A Delphi consensus recommendation.

J Hosp Med 2022 Jun 13. Epub 2022 Jun 13.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: Thyroid-stimulating hormone (TSH) is ordered commonly among inpatients, but the possibility of nonthyroidal illness syndrome challenges interpretation.

Objective: Our objective was to obtain Canadian consensus on appropriate indications for ordering TSH in the first 48 h following presentation of a noncritically ill internal medicine patient.

Design, Setting And Participants: Canadian endocrinologists with inpatient expertise were invited via snowball sampling to an online 3-round Delphi study. Read More

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Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series.

SAGE Open Med Case Rep 2022 7;10:2050313X221102289. Epub 2022 Jun 7.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Drexel University College of Medicine and St. Christopher's Hospital for Children, Philadelphia, PA, USA.

Treatment of neonates with persistent pulmonary hypertension of newborn includes optimization of ventilatory support, use of pulmonary vasodilators, and/or inotropic support. If refractory to this management, some may require extracorporeal membrane oxygenation. We describe a case series of 10 neonates with refractory persistent pulmonary hypertension of newborn treated with vasopressin in a single tertiary center. Read More

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Safety of Contemporary Carotid Artery Stenting and Associated Risk Factors for Treatment of Carotid Artery Stenosis.

World Neurosurg 2022 Jun 9. Epub 2022 Jun 9.

Department of Neurosurgery, Baylor Scott & White Health, Scott and White Medical Center, Temple, Texas, USA; Department of Surgery, Texas A&M University College of Medicine, Temple, Texas, USA.

Background: The prevalence of carotid artery atherosclerosis and stroke is increasing. Carotid artery stenting (CAS), which treats carotid artery stenosis and prevents strokes, has benefited from advances in techniques and technology. In this study, we aimed to identify significant risk factors for major complications following contemporary CAS. Read More

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Observational Study of the Association between Hyponatremia and Rhabdomyolysis in Patients Presenting to Hospital.

J Clin Med 2022 Jun 5;11(11). Epub 2022 Jun 5.

Department of General Medicine, Monash Health, Clayton, VIC 3168, Australia.

Hyponatremia may be a risk factor for rhabdomyolysis, but the association is not well defined and may be confounded by other variables. The aims of this study were to determine the prevalence and strength of the association between hyponatremia and rhabdomyolysis and to profile patients with hyponatremia. In a cross-sectional study of 870 adults admitted to hospital with rhabdomyolysis and a median peak creatine kinase of 4064 U/L (interquartile range, 1921-12,002 U/L), glucose-corrected serum sodium levels at presentation showed a U-shape relationship to log peak creatine kinase. Read More

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