14,680 results match your criteria Hyponatremia


Deferasirox-induced liver injury and Fanconi syndrome in a beta-thalassemia major male.

BMJ Case Rep 2020 Jul 9;13(7). Epub 2020 Jul 9.

Gastroenterology and Hepatology Department, Northern Health, Epping, Victoria, Australia.

A 33-year-old male presenting with subacute abdominal pain was found to have hyperbilirubinaemia, hypokalaemia and hyponatraemia. This was in the setting of transitioning between deferasirox iron chelator formulations, from dispersible tablets to film-coated tablets for ongoing treatment of chronic iron overload secondary to transfusion requirement for beta-thalassemia major. A liver biopsy demonstrated acute cholestasis with patchy confluent hepatocellular necrosis and mild to moderate microvesicular steatosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-234542DOI Listing

SGLT-2 Inhibitors to Treat Hyponatremia Associated with SIADH: A Novel Indication?

Am J Nephrol 2020 Jul 9:1-3. Epub 2020 Jul 9.

IIS-Fundacion Jimenez Diaz, School of Medicine, University Autonoma of Madrid, FRIAT and REDINREN, Madrid, Spain.

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http://dx.doi.org/10.1159/000509082DOI Listing

A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors.

MAbs 2020 Jan-Dec;12(1):1773751

Department of Oncology, St. Jude Children's Research Hospital , Memphis, TN, USA.

Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m daily for 4 days in children with recurrent/refractory neuroblastoma. We report additional results of a Phase 1 trial to determine the MTD and safety profile of hu14. Read More

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http://dx.doi.org/10.1080/19420862.2020.1773751DOI Listing

Follow-Up of Brain Single-Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI) in a Case of Seizure Caused by Osmotic Demyelination Syndrome.

Am J Case Rep 2020 Jul 9;21:e923406. Epub 2020 Jul 9.

Department of Radiology, Chosun University Hospital, Gwangju, South Korea.

BACKGROUND Osmotic demyelination syndrome (ODS) is an uncommon neurological disorder. Until the mid-1980s, the mortality rate was 90-100%, but more than half of patients now have a good prognosis. Early suspicion of ODS is important. Read More

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http://dx.doi.org/10.12659/AJCR.923406DOI Listing

Feasibility of Citrate Dialysis in Hyponatremia: A Case Series.

Blood Purif 2020 Jul 8:1-6. Epub 2020 Jul 8.

ICU Department, Brugmann University Hospital, Brussels, Belgium.

Background: Correcting hyponatremia too quickly can lead to osmotic demyelination syndrome. During citrate dialysis, a significant sodium load is brought to the prefilter. We reviewed the impact of this sodium load on the evolution of sodium levels in patients undergoing continuous renal replacement therapy with citrate anticoagulation. Read More

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http://dx.doi.org/10.1159/000509024DOI Listing

Atypical Presentation of COVID-19 in an Older Adult: Lethargy and Vomiting from Severe Hypovolemic Hyponatremia.

Geriatr Gerontol Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Geriatric Medicine, Changi General Hospital, Singapore.

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http://dx.doi.org/10.1111/ggi.13990DOI Listing

Hepatocellular Carcinoma With Tumor Thrombus to the Hepatic Veins and the Right Atrium: A Case Report and Review Exploring Various Presentations and Treatment Options.

Cureus 2020 Jun 2;12(6):e8405. Epub 2020 Jun 2.

Internal Medicine, Legacy Health, Portland, USA.

Hepatocellular carcinoma (HCC) is a leading cause of cancer and cancer-related deaths in the world. Some of the risk factors for the development of HCC include Hepatitis B virus (HBV), Hepatitis C virus (HCV), chronic alcoholism, autoimmune hepatitis, among others. One manifestation of HCC includes tumor thrombus (TT) to the right atrium (RA), which occurs in 0. Read More

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http://dx.doi.org/10.7759/cureus.8405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331928PMC

The Role of Hyponatraemia Before Surgery in Patients With Radical Resected Pancreatic Cancer.

Clin Med Insights Oncol 2020 26;14:1179554920936605. Epub 2020 Jun 26.

Vita-Salute San Raffaele University, Milan, Italy.

Objectives: Hyponatraemia represents a negative prognostic factor in patients with cancer. The aim of this study was to assess, for the first time, the role of hyponatraemia in patients undergoing radical surgery for pancreatic ductal adenocarcinoma.

Methods: A total of 89 patients with stage I-III pancreatic ductal adenocarcinoma underwent radical surgery between November 2012 and October 2014. Read More

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http://dx.doi.org/10.1177/1179554920936605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322821PMC

In-hospital resource utilization, worsening heart failure, and factors associated with length of hospital stay in patients with hospitalized heart failure: A Japanese database cohort study.

J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Medical Division, Novartis Pharma K.K., Tokyo, Japan.

Background: Our objective was to characterize cases of hospitalized heart failure (HHF) focusing on in-hospital resource utilization (particularly furosemide doses) and worsening heart failure (WHF), and identify which factors are associated with the length of stay (LOS).

Methods: Cases of HHF (≥20 years), excluding those undergoing surgical procedures and in-hospital deaths, were retrieved from the Japanese Diagnosis Procedure Combination database (April 2012 to March 2016). WHF was defined using eight components, including up-titration of intravenous drugs and non-pharmacological management. Read More

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http://dx.doi.org/10.1016/j.jjcc.2020.05.010DOI Listing

A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome.

Scand J Gastroenterol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of GI surgery, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure.

Aim: To evaluate the effect of terlipressin and albumin combination in various clinical outcomes in Hepatorenal Syndrome patients It was a prospective study involving 50 patients with HRS. The effectiveness parameters of the treatments were: confirmed HRS reversal, Recurrence of HRS within 90 days of treatment and mortality rate up to 90 days. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786851DOI Listing

Impact of Rhabdomyolysis on outcomes of hospitalizations for heat stroke in the United States.

Hosp Pract (1995) 2020 Jul 7. Epub 2020 Jul 7.

Department of Military and Community Medicine, Phramongkutklao College of Medicine , Bangkok, Thailand.

Background: The objective of this study was to evaluate the predictors and associated outcomes of rhabdomyolysis in admitted patients for heat stroke in the United States.

Methods: The National Inpatient Sample was utilized to identify hospitalized patients with a primary diagnosis of heat stroke from the years 2003-2014. Rhabdomyolysis was identified using hospital diagnosis code. Read More

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http://dx.doi.org/10.1080/21548331.2020.1792214DOI Listing

COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult.

Am J Emerg Med 2020 Jun 25. Epub 2020 Jun 25.

Division of Rheumatology, Maimonides Medical Center, Brooklyn, NY, United States of America. Electronic address:

Recent reports have described a secondary Multisystem Inflammatory Syndrome in Children (MIS-C) after a prior COVID-19 infection that often has features of Kawasaki disease (KD). Here, we report the case of a 36-year-old woman who presented to the emergency department hypotensive and tachycardic after 1 week of fevers, abdominal pain, vomiting and diarrhea, and was found to have the classic phenotype of complete Kawasaki's Disease including nonexudative conjunctivitis, cracked lips, edema of the hands and feet, palmar erythema, a diffuse maculopapular rash, and cervical lymphadenopathy. Initial laboratory studies were significant for hyponatremia, elevated liver function tests including direct hyperbilirubinemia, and leukocytosis with neutrophilia. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.06.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315983PMC

Sex Differences in Clinical Characteristics and 1- and 10-Year Mortality Among Patients Hospitalized With Acute Heart Failure.

Am J Med Sci 2020 May 27. Epub 2020 May 27.

The Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sakler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: The impact of sex on mortality in patients with acute heart failure (AHF) is unresolved. We aimed to investigate the impact of sex on both short- and long-term mortality outcomes after hospitalization for AHF.

Methods: We analyzed data of 2,328 patients with AHF who were enrolled in the multicenter national survey in Israel between March and April 2003 and followed up until December 2014. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.05.028DOI Listing

Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts.

Medicine (Baltimore) 2020 Jul;99(27):e20931

Department of Internal Medicine C, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Various psychotropic drugs may affect the hematological and biochemical profiles of plasma and its metabolism. Carbamazepine, the most well-known psychotropic drug, can cause substantial hyponatremia. Methylphenidate, a piperidine derivative structurally related to amphetamines, acts as a central nervous system stimulant. Read More

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http://dx.doi.org/10.1097/MD.0000000000020931DOI Listing

[Clinical features and outcomes in relapsing and monophasic patients with anti-leucine-rich glioma-inactivated 1 encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1947-1951

Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To analyze the differences of clinical characteristics and outcomes between relapsing and monophasic patients with anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis. Medical records of confirmed anti-LGI1 encephalitic patients who underwent immunotherapy were retrospectively collected from January 2015 to January 2019 in the first affiliated hospital of Zhengzhou University. Clinical data, treatment methods, duration of treatment and outcomes were analyzed between the relapsing and monophasic groups. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200330-01001DOI Listing

[A case of colchicine poisoning complicated with extra pontine myelinolysis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Jun;38(6):461-462

Department of Emergency, The First Hospital of Jilin University, Jilin 130021, China.

To analyze the clinical presentation and the treatment process of one case of colchicine poisoning complicated with extra pontine myelinolysis and discuss its pathogenesis. Increasing the attention of hyponatremia caused by colchicine poisoning is of great significance for improving the prognosis and quality of life of patients. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190918-00384DOI Listing

Risk factors associated with 30-day hospital readmission after carotid endarterectomy.

Vascular 2020 Jul 5:1708538120937955. Epub 2020 Jul 5.

Division of Vascular Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.

Objective: The current study evaluated all-cause 30-day readmissions after carotid endarterectomy.

Methods: Patients undergoing carotid endarterectomy were selected from the Cerner Health Facts® database using ICD-9-CM procedure codes from their index admission. Readmission within 30 days of discharge was determined. Read More

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http://dx.doi.org/10.1177/1708538120937955DOI Listing

[Long-term effects of dibenzazepines on metabolic parameters: retrospective comparison of carbamazepine, oxcarbazepine and eslicarbazepine acetate in the real world].

Rev Neurol 2020 Jul;71(2):54-60

Hospital del Mar, Barcelona, España.

Introduction: Although carbamazepine (CBZ) has strong enzyme-inducing properties, oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) are thought to have a milder effect. These drugs are known to have effects on lipid metabolism and may cause hyponatremia and changes in blood cell counts and liver function tests.

Aim: To compare the long-term effects of three antiepileptic drugs (CBZ, OXC and ESL) on these variables. Read More

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http://dx.doi.org/10.33588/rn.7102.2019207DOI Listing

STAR mutations causing non‑classical lipoid adrenal hyperplasia manifested as familial glucocorticoid deficiency.

Mol Med Rep 2020 Aug 7;22(2):681-686. Epub 2020 May 7.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterized by single cortisol deficiency but normal aldosterone and renin levels. Beginning from the discovery of the disease to that of the pathogenic genes over a period of 30 years, the development of gene detection technology has identified a large number of FGD‑related genes. Despite the fact that the genetic defect underlying this disease is known for approximately 70% of the patients diagnosed with FGD, there are still several unknown factors causing it. Read More

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http://dx.doi.org/10.3892/mmr.2020.11140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339677PMC

Hyponatraemia and cerebral oedema due to a modafinil overdose.

BMJ Case Rep 2020 Jul 5;13(7). Epub 2020 Jul 5.

Brain Injury Rehabilitation Unit, North Bristol NHS Trust, Bristol, Avon, UK.

Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology and management of overdose. We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. Read More

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http://dx.doi.org/10.1136/bcr-2020-234530DOI Listing

The association between hyponatraemia and long-term functional outcome in patients with aneurysmal subarachnoid haemorrhage: A single centre prospective cohort study.

J Clin Neurosci 2020 Jul 1. Epub 2020 Jul 1.

Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia; Division of Critical Care, The George Institute for Global Health, University of New South Wales, Sydney, Australia. Electronic address:

To assess the association between hyponatraemia and long-term functional outcome and other relevant outcomes in patients with aneurysmal subarachnoid haemorrhage (aSAH) we conducted a prospective cohort study in a Neurosciences Intensive Care Unit (ICU) in Sydney, Australia. The primary exposure variable was hyponatraemia (Na <135 mmol/L). The primary outcome was favourable outcome, a score of 5-8 on the extended Glasgow Outcome Score (GOSe) at 12 months. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.06.003DOI Listing

A Case of Persistent Muscle Cramps in an American Football Player With Cystic Fibrosis.

Cureus 2020 Jun 14;12(6):e8621. Epub 2020 Jun 14.

Family and Community Medicine/Orthopedics and Rehabilitation, Penn State Health/College of Medicine, Hershey, USA.

Exercised-associated muscle cramp (EAMC) is a common occurrence in sports medicine. We highlight a 17-year-old male high-school football player with a history of cystic fibrosis and hyponatremic seizure, who presented for recurrent EAMC. After establishing an appropriate electrolyte replacement and hydration plan, he was able to complete his season with minimal symptoms. Read More

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http://dx.doi.org/10.7759/cureus.8621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325396PMC

Intensive care unit-acquired hyponatremia in critically ill medical patients.

J Transl Med 2020 Jul 2;18(1):268. Epub 2020 Jul 2.

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The aim of this study is to investigate the incidence of ICU-acquired hyponatremia, the risk factors associated with its development, and its impact on outcomes in critically ill medical patients.

Methods: We conducted a retrospective cohort study based on the prospective registry of all critically ill patients admitted to the medical ICU from January 2015 to December 2018. Read More

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http://dx.doi.org/10.1186/s12967-020-02443-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333267PMC

Impact of salt substitute and stepwise reduction of salt supply on blood pressure in residents in senior residential facilities: Design and rationale of the DECIDE-Salt trial.

Am Heart J 2020 May 30;226:198-205. Epub 2020 May 30.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China; Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China. Electronic address:

Background: High sodium intake has been considered as the leading dietary risk factor for deaths and disability-adjusted life-years among older adults. High-quality randomized trials to evaluate the effects of practical sodium reduction strategies are needed.

Methods: The study is a cluster randomized trial with a 2 × 2 factorial design conducted in 48 senior residential facilities in northern China. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.013DOI Listing

Third time's a charm: diagnosis of herpes simplex encephalitis after two negative polymerase chain reaction results.

Heliyon 2020 Jun 23;6(6):e04247. Epub 2020 Jun 23.

Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Introduction: Polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) is a sensitive and specific method in diagnosing herpes simplex virus (HSV) encephalitis. However there are increasing reports of false negative HSV PCR.

Case Description: We present a patient in the 9 decade of life with abnormal behavior and focal seizures with MRI showing a right temporal T2 hyperintense non-enhancing lesion with electrographic evidence of right lateralized periodic discharges. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322049PMC

A case of rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone.

Respir Med Case Rep 2020 17;30:101136. Epub 2020 Jun 17.

Department of Pathology, Yamanashi Prefectural Central Hospital, Japan.

A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322342PMC

The Curious Story of Cerebral Salt Wasting: Fact or Fiction?

Clin J Am Soc Nephrol 2020 Jul 1. Epub 2020 Jul 1.

Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC

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http://dx.doi.org/10.2215/CJN.00070120DOI Listing

The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications.

Clin Microbiol Rev 2020 Sep 1;33(4). Epub 2020 Jul 1.

Human Metabolomics, North-West University, Potchefstroom, North West, South Africa.

SUMMARYClinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe reactions, such as irreversible lung damage and, eventually, death, depending on disease progression. In addition to its clinical presentation, TB has been associated with several other disease-induced systemic complications, such as hyponatremia and glucose intolerance. Here, we provide an overview of the known, although ill-described, underlying biochemical mechanisms responsible for the clinical and systemic presentations associated with this disease and discuss novel hypotheses recently generated by various omics technologies. Read More

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http://dx.doi.org/10.1128/CMR.00036-20DOI Listing
September 2020

Comparative Analysis of Clinical and Biochemical Profile of Exertional Heat Related Illness Among Cadets in a Military Training Centre in South India: A Single Centre Experience.

J Assoc Physicians India 2020 Apr;68(4):29-31

Senior Advisor Medicine and Oncology, Command Hospital, Bengaluru, Karnataka.

Background: Heat-related illnesses includes a range of manifestation starting from minor illness like heat rashes/ heat cramps to more complicated illness like heat exhaustion and the most severe heat stroke. Often derangements in biochemical parameters including metabolic acidosis, respiratory alkalosis, electrolytes, transminitis and renal dysfunction are noticed in patients with heat stroke. Objective: The present study was an attempt to compare the clinical and changes in biochemical parameters in exertional heat exhaustion and heat stroke patients among cadets from a military training centre admitted to an Armed forces hospital in South India. Read More

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Efficacy of Goreisan in Preventing Transurethral Resection Syndrome in Transurethral Resection of the Prostate: A Randomized-Controlled Study.

J Altern Complement Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Anesthesiology, Osaka Medical College, Osaka, Japan.

Nonconductive irrigation fluids used during transurethral resection (TUR) of the prostate can cause fluid overload and dilutional hyponatremia. TUR syndrome is generally defined as serum sodium at or below 125 mmol/L with cardiovascular and neurologic symptoms. The aim of this study was to evaluate the effects of Goreisan, a traditional Japanese Kampo medicine, on serum sodium levels and the occurrence of TUR syndrome in patients undergoing TUR of the prostate. Read More

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http://dx.doi.org/10.1089/acm.2019.0269DOI Listing

Isolated second-phase diabetes insipidus post-transsphenoidal surgery.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Diabetes and Endocrinology, Mater Dei Hospital, Msida, Malta.

A 57-year-old woman presented with severe lethargy, dizziness and nausea 1 week after transsphenoidal resection of a growth hormone secreting pituitary adenoma. She was found to have severe hyponatremia of 115 mmol/L. Importantly, she was neurologically intact and clinically euvolaemic. Read More

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http://dx.doi.org/10.1136/bcr-2020-235499DOI Listing

Duloxetine Induced Hyponatremia.

Turk Psikiyatri Derg 2019 ;30(4):287-289

Hyponatremia can be asymptomatic or have a wide range of clinical presentations such as headaches, muscle cramps, nausea, seizures, coma, cerebral edema and may even result in death. Despite it has been suggested that duloxetine has a relatively less risk of hyponatraemia, the number of case reports are increasing. A 45- year old female patient with complaints of fear, anxiety, sleeplessness and headache was started on duloxetine (30 mg/day). Read More

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January 2019

Compromised regulation of the rat brain parenchymal arterioles in vasopressin-associated acute hyponatremia.

Microcirculation 2020 Jun 30. Epub 2020 Jun 30.

Laboratory of Experimental and Clinical Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

Objective: In this study, we examined the effect of acute hyponatremia associated with vasopressin (AVP) on the responses of the isolated rat's middle cerebral arteries (MCAs) and parenchymal arterioles (PAs) to acidosis, nitric oxide donor (SNAP) and to endothelium-dependent vasodilator adenosine triphosphate (ATP).

Methods: The studies were performed on isolated, perfused and pressurized MCAs and PAs in control conditions and during AVP-associated hyponatremia. Hyponatremia was induced in vitro by lowering Na concentration from 144 to 121 mM in intra- and extravascular fluid in the presence of AVP. Read More

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http://dx.doi.org/10.1111/micc.12644DOI Listing

Endocrine and Metabolic Manifestations of Snakebite Envenoming.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Department of Endocrinology, Manipal Hospital, New Delhi, India.

Snake envenoming is a neglected, public health problem in tropical and subtropical regions. Local tissue necrosis, neurotoxic, and hemo-vasculotoxic effects are well-recognized features, whereas the endocrine and metabolic derangements are not as well known. In addition to contributing to morbidity, some of these manifestations can be potentially life-threatening if not recognized early. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0161DOI Listing

Colonic obstruction in a tetraplegic patient: a common symptom from an uncommon cause.

Spinal Cord Ser Cases 2020 Jun 29;6(1):53. Epub 2020 Jun 29.

Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Introduction: It is difficult to diagnose an acute abdomen condition in people with spinal cord injury due to abnormal sensation below the injured level and multiple co-morbidities. These issues can mislead the exact diagnosis and delay proper treatment.

Case Presentation: A 57-year-old male with C4 AIS C tetraplegia developed nausea and vomiting, abdominal distension and feeding intolerance. Read More

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http://dx.doi.org/10.1038/s41394-020-0305-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324610PMC

[Some practical issues in the management of patients with decompensated liver cirrhosis].

Ter Arkh 2019 Aug 15;91(8):148-154. Epub 2019 Aug 15.

Sechenov First Moscow State Medical University (Sechenov University).

The natural course of cirrhosis is characterized by a shift from a compensated stage without clinical manifestations to a subsequent decompensated stage, which is characterized by the development of obvious clinical symptoms, the most frequent of which are ascites, bleeding from varicose veins, bacterial infections, encephalopathy. The articles and reviews of recent years emphasize the importance of etiotropic treatment of liver cirrhosis at any stage, including the final one. In addition, pathogenetic and symptomatic therapy aimed at treating complications of cirrhosis of the liver: ascites, dilution hyponatremia, gastrointestinal bleeding, bacterial infections, and kidney damage comes to the forefront at the stage of decompensation, which allows the patient to be on the waiting list for liver transplantation. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000391DOI Listing

Neurobrucellosis Presented by Cerebral Salt Wasting.

Cureus 2020 May 25;12(5):e8275. Epub 2020 May 25.

Internal Disease, Batman District State Hospital, Batman, TUR.

This case reported here was a 27-year-old female patient, and she had no chronic disease other than hypothyroidism. She was brought to the ER with complaints of fever, chills, weakness, and hyponatremia. She has been diagnosed with brucellosis using a serum tube agglutination test (STAT). Read More

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http://dx.doi.org/10.7759/cureus.8275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314369PMC

Point-of-care ultrasound to evaluate volume status in severe hyponatremia.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Department of Internal Medicine, Prisma Health, Greenville, South Carolina, USA

A 51-year-old man was hospitalised for severe hyponatremia. Initial history and physical examination suggested hypovolemia, and he was treated with normal saline at 100 mL/hour. After several days, his hyponatremia failed to improve, and then worsened without resolution of presenting ataxia and fatigue. Read More

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http://dx.doi.org/10.1136/bcr-2020-235304DOI Listing

Rare case of pseudohypoaldosteronism in a neonate secondary to congenital hydrometrocolpos.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Department of Paediatrics and Neonatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Pseudohypoaldosteronism (PHA) due to obstructive uropathy, urinary tract infections and congenital urogenital malformations has been reported in the literature; however, there are no reports of PHA associated with hydrometrocolpos due to a common urogenital tract. Hydrometrocolpos is a condition resulting in distension of the vagina and uterus due to accumulation of secretions (other than blood), caused by increased oestrogenic stimulation and vaginal outflow obstruction. We report on a neonatal case of PHA caused by recurrent hydrometrocolpos presenting with vomiting and poor weight gain. Read More

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http://dx.doi.org/10.1136/bcr-2020-234813DOI Listing

Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report.

J Med Case Rep 2020 Jun 29;14(1):83. Epub 2020 Jun 29.

Department of Internal Medicine, Diakonessenhuis, Bosboomstraat 1., 3582, K.E., Utrecht, The Netherlands.

Background: Hyponatremia is the most common electrolyte disorder. Thiazides, antidepressants, antipsychotic drugs, and antiepileptic drugs are well-known causes of hyponatremia. Proton pump inhibitor use is a rare cause of hyponatremia and, when reported, it is due to one specific proton pump inhibitor, mostly omeprazole. Read More

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http://dx.doi.org/10.1186/s13256-020-02423-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322854PMC

Transient hyponatremia of prematurity caused by mild Bartter syndrome type II: a case report.

BMC Pediatr 2020 Jun 26;20(1):311. Epub 2020 Jun 26.

Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON, N6A5C1, Canada.

Background: Bartter syndrome subtypes are a group of rare renal tubular diseases characterized by impaired salt reabsorption in the tubule, specifically the thick ascending limb of Henle's loop. Clinically, they are characterized by the association of hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, increased levels of plasma renin and aldosterone, low blood pressure and vascular resistance to angiotensin II. Bartter syndrome type II is caused by mutations in the renal outer medullary potassium channel (ROMK) gene (KCNJ1), can present in the newborn period and typically requires lifelong therapy. Read More

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http://dx.doi.org/10.1186/s12887-020-02214-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318402PMC

Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial.

Lancet Haematol 2020 Jul;7(7):e511-e522

Hospital Universitario La Paz, Madrid, Spain.

Background: Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer with a median overall survival of less than 6 months. We aimed to assess the response to single-agent selinexor, an oral selective inhibitor of nuclear export, in patients with relapsed or refractory DLBCL who had no therapeutic options of potential clinical benefit.

Methods: SADAL was a multicentre, multinational, open-label, phase 2b study done in 59 sites in 19 countries. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30120-4DOI Listing

Estimation of homeostatic dysregulation and frailty using biomarker variability: a principal component analysis of hemodialysis patients.

Sci Rep 2020 Jun 25;10(1):10314. Epub 2020 Jun 25.

Division of Nephrology, Yuai Clinic, Hakuyukai Medical Corporation, Saitama-City, Saitama, Japan.

Increased intraindividual variability in several biological parameters is associated with aspects of frailty and may reflect impaired physiological regulation. As frailty involves a cumulative decline in multiple physiological systems, we aimed to estimate the overall regulatory capacity by applying a principal component analysis to such variability. The variability of 20 blood-based parameters was evaluated as the log-transformed coefficient of variation (LCV) for one year's worth of data from 580 hemodialysis patients. Read More

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http://dx.doi.org/10.1038/s41598-020-66861-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316742PMC

Diabetes insipidus and syndrome of inappropriate antidiuresis (SIADH) after pituitary surgery: incidence and risk factors.

Neurosurg Rev 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Electrolyte disorders are relatively frequent and potentially serious complications after pituitary surgery. Both DI (diabetes insipidus) and SIADH (syndrome of inappropriate antidiuresis) can complicate and prolong hospital and intensive care unit stay, and the latter may even be preventable. We aim to assess the incidence of both electrolyte disorders and their risk factors. Read More

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http://dx.doi.org/10.1007/s10143-020-01340-0DOI Listing

Risk Factors Associated With Long-Term Hospitalization in Patients With COVID-19: A Single-Centered, Retrospective Study.

Front Med (Lausanne) 2020 9;7:315. Epub 2020 Jun 9.

BE and Phase i Clinical Trial Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.

The coronavirus disease 19 (COVID-19) pandemic has become a global threat. Few studies have explored the risk factors for the recovery time of patients with COVID-19. This study aimed to explore risk factors associated with long-term hospitalization in patients with COVID-19. Read More

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http://dx.doi.org/10.3389/fmed.2020.00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296106PMC

Olanzapine-Induced Hyponatremia Presenting with Seizure Requiring Intensive Care Unit Admission.

Cureus 2020 May 20;12(5):e8212. Epub 2020 May 20.

Psychiatry, John P. and Kathrine G. McGovern Medical School at University of Texas Health Science Center, Houston, USA.

Rapid-onset hyponatremia is a rare, but potential, complication of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with a syndrome of inappropriate anti-diuretic hormone secretion (SIADH). Psychogenic polydipsia is a separate cause of hyponatremia, which is also seen in the psychiatric population, particularly in schizophrenia, and must be differentiated from SIADH. Read More

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http://dx.doi.org/10.7759/cureus.8212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305579PMC

Osmotic Demyelination Syndrome Despite Appropriate Hyponatremia Correction.

Cureus 2020 May 20;12(5):e8209. Epub 2020 May 20.

Radiology, St. Barnabas Hospital Health System, Albert Einstein College of Medicine, Bronx, USA.

Acute demyelination of the pons or extrapontine areas results in an osmotic demyelination syndrome (ODS), previously referred to as central pontine myelinolysis (CPM) or extra pontine myelinolysis (EPM). It is caused by osmotic dysregulation in the brain. Multiple risk factors have been known to contribute to these osmotic disturbances. Read More

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http://dx.doi.org/10.7759/cureus.8209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305570PMC

Challenges in the diagnostics and management of hydrochlorothiazide-induced severe hyponatremia in a habitual beer drinker.

Acta Med Litu 2020 ;27(1):39-44

Centre of Toxicology, Republican Vilnius University Hospital, Faculty of Medicine, Vilnius University, Clinic of Anaesthesiology and Intensive Care, Vilnius, Lithuania.

Introduction: Beer potomania is a syndrome of severe hyponatremia caused by excessive beer consumption. The risk of hyponatremia increases in the case of a combination of beer potomania and the use of thiazide diuretics.

Case Report: A55-year-old male patient with the anamnesis of a long-lasting alcohol use disorder was presented to the emergency department after seizures accompanied by an impaired mental status. Read More

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http://dx.doi.org/10.6001/actamedica.v27i1.4265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305805PMC
January 2020

In Reply to 'Treatment Outcomes in Syndrome of Inappropriate Antidiuresis: Improvements in Hyponatremia May Reflect Successful Treatment or Resolution of the Underlying Cause'.

Am J Kidney Dis 2020 Jun 20. Epub 2020 Jun 20.

Pharmacoepidemiology and Statistics Research Center (PESRC), Faculty of Pharmacy, Chiang Mai University, Thailand.

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http://dx.doi.org/10.1053/j.ajkd.2020.06.003DOI Listing