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    Hyponatremia, falls and bone fractures: a systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.
    Endocrine Unit ", University of Florence, Florence, Italy.
    Objective: To perform a meta-analysis based on published studies that compared falls and bone fractures between patients with and without hyponatremia.

    Context: There is evidence suggesting that hyponatremia is associated with an increased risk of falls and bone fractures.

    Design: An extensive Medline, Embase and Cochrane search was performed to retrieve all studies published up to, April 30 2017, using the following words: "hyponatremia" or "hyponatraemia" AND "falls" and "bone fractures". Read More

    Implementation of an Urogynecology-Specific Enhanced Recovery After Surgery (ERAS) Pathway.
    Am J Obstet Gynecol 2018 Jun 15. Epub 2018 Jun 15.
    Department of Obstetrics, Gynecology and Reproductive Sciences of the University of Pittsburgh, Division of Urogynecology and Pelvic Reconstructive Surgery Magee-Womens Hospital of UPMC, Pittsburgh, PA.
    Objectives: ERAS protocols were developed for colorectal surgery to hasten post-op recovery. Variations of the protocol are being adopted for gynecologic procedures despite limited population and procedure-specific outcome data. Our objective was to evaluate if implementation of an ERAS pathway would facilitate reduced length of admission in an urogynecology population. Read More

    Physiology and Pathophysiology in Ultra-Marathon Running.
    Front Physiol 2018 1;9:634. Epub 2018 Jun 1.
    Exercise Physiology Laboratory, Nikaia, Greece.
    In this overview, we summarize the findings of the literature with regards to physiology and pathophysiology of ultra-marathon running. The number of ultra-marathon races and the number of official finishers considerably increased in the last decades especially due to the increased number of female and age-group runners. A typical ultra-marathoner is male, married, well-educated, and ~45 years old. Read More

    An updated assessment of morbidity and mortality following skull base surgical approaches.
    Clin Neurol Neurosurg 2018 Jun 10;171:109-115. Epub 2018 Jun 10.
    Department of Anesthesiology, University of California, San Diego, San Diego, CA, USA; Department of Medicine, Division of Biomedical Informatics, University of California, San Diego, San Diego, CA, USA. Electronic address:
    Objectives: Updated multi-institutional database studies assessing perioperative risk factors on 30-day morbidity and mortality after skull base surgeries are limited. We aim to identify perioperative risk factors and report the incidence of 30-day morbidity and mortality in adult patients after skull base surgery.

    Patients And Methods: We queried the 2007-2016 American College of Surgeons National Surgical Quality Improvement program database to identify patients who underwent anterior, middle, or posterior skull base surgery. Read More

    Schmidt’s syndrome: a difficult diagnosis in the Latin American context
    Rev Med Inst Mex Seguro Soc 2018 Mar-Apr;56(2):189-193
    Facultad de Ciencias de la Salud, Escuela de Medicina, Departamento de Investigación. Lima, Perú
    Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. Read More

    Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction.
    J Am Heart Assoc 2018 Jun 13;7(12). Epub 2018 Jun 13.
    Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA
    Background: The purpose of this study was to evaluate the relationship between serum sodium at the time of diagnosis and long term clinical outcomes in a large national cohort of patients with heart failure with preserved ejection fraction.

    Methods And Results: We studied 25 440 patients with heart failure with preserved ejection fraction treated at Veterans Affairs medical centers across the United States between 2002 and 2012. Serum sodium at the time of heart failure diagnosis was analyzed as a continuous variable and in categories as follows: low (115. Read More

    Carbamazepine adverse drug reactions.
    Expert Rev Clin Pharmacol 2018 Jun 19:1-14. Epub 2018 Jun 19.
    e Department of Biological Systems , Metropolitan Autonomous University , Coyoacán, Mexico City , Mexico.
    Introduction: Carbamazepine (CBZ) is used for the treatment of epilepsy and other neurological and psychiatric disorders. The occurrence of adverse reactions (ADRs) to CBZ can negatively impact the quality of life of patients, as well as increase health-care costs. Thus, knowledge of CBZ-induced ADRs is important to achieve safer treatment outcomes. Read More

    [Canine hypoadrenocorticism - an update on pathogenesis, diagnosis and treatment].
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Jun 13;46(3):163-175. Epub 2018 Jun 13.
    Canine hypoadrenocorticism (HoAC) results from a loss of functional adrenal cortex, the most common etiology of which is an immune-mediated destruction leading to an inadequate production of glucocorticoids and mineralocorticoids. The term "atypical" HoAC is used for a subgroup of dogs with either an isolated glucocorticoid deficiency or a combined glucocorticoid and mineralocorticoid deficiency but normal electrolytes. Dogs with HoAC can present with a large variety of clinical signs, ranging from shaking, weakness, and mild gastrointestinal signs to seizures, hypovolemic shock, and collapse. Read More

    Editor's Choice-Diuretic resistance in acute heart failure.
    Eur Heart J Acute Cardiovasc Care 2018 Jun;7(4):379-389
    Department of Cardiology, Jessa Ziekenhuis, Belgium.
    Diuretic resistance is a powerful predictor of adverse outcome in acute heart failure (AHF), irrespectively of underlying glomerular filtration rate. Metrics of diuretic efficacy such as natriuresis, urine output, weight loss, net fluid balance, or fractional sodium excretion, differ in their risk for measurement error, convenience, and biological plausibility, which should be taken into account when interpreting their results. Loop diuretic resistance in AHF has multiple causes including altered drug pharmacokinetics, impaired renal perfusion and effective circulatory volume, neurohumoral activation, post-diuretic sodium retention, the braking phenomenon and functional as well as structural adaptations in the nephron. Read More

    Osmotic Demyelination Syndrome in an Adolescent with Neuromyelitis Optica.
    Int J MS Care 2018 May-Jun;20(3):142-144
    A 17-year-old girl presented with intractable vomiting due to area postrema involvement in the first presentation of seronegative neuromyelitis optica (NMO). During the course of her illness, she developed mild hyponatremia, and magnetic resonance imaging revealed abnormalities consistent with the co-occurrence of osmotic demyelination syndrome (ODS). This combination of imaging features is novel, and this case expands the spectrum of brain abnormalities seen in NMO and NMO spectrum disorders. Read More

    Histidine-Tryptophan-Ketoglutarate Solution versus Blood Cardioplegia in Cardiac Surgery: A Propensity-Score Matched Analysis.
    Heart Surg Forum 2018 05 11;21(3):E158-E164. Epub 2018 May 11.
    Department of Cardiovascular Surgery, Fundación CardioInfantil – Instituto de Cardiología, Universidad del Rosario, Bogotá, Colombia
    Background: Choosing a cardioplegic solution is a significant issue in modern cardiac surgery. Although different options are available, the optimal strategy for myocardial protection has not been established. The aim of this study was to compare intraoperative and postoperative effects of histidine-tryptophan-ketoglutarate (HTK) solution with those of standard blood cardioplegia with St Thomas No 2 solution. Read More

    Biocomputing for portable, resettable and quantitative point-of-care diagnostics: making glucose meter a logic-gate responsive device to many targets in clinical care.
    Angew Chem Int Ed Engl 2018 Jun 12. Epub 2018 Jun 12.
    University of Illinois, Chemistry, 600 South Mathews Ave., 61801, Urbana, UNITED STATES.
    While biocomputing is recognized to provide intelligent solution to complex biosensing projects, it remains challenging to transform biomolecular logic gates into a convenient, portable, resettable and quantitative sensing system for point-of-care (POC) diagnostics in a low-resource setting. To overcome these limitations, we herein report the first design and demonstration of biocomputing on personal glucose meters (PGM) by utilizing glucose and nicotinamide adenine dinucleotide as signal outputs, DNAzyme and protein enzymes as building blocks and demonstrating a general platform for installing logic-gate responses (YES, NOT, INHIBIT and OR) to a variety of biological species, such as cations (sodium), anions (citrate), organic metabolites (ADP, ATP) and enzymes (pyruvate kinase, alkaline phosphatase, alcohol dehydrogenases). A concatenated logical gate platform that is resettable is also demonstrated. Read More

    Relative adrenal insufficiency in cirrhotic patients with ascites (hepatoadrenal syndrome).
    Dig Liver Dis 2018 May 23. Epub 2018 May 23.
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
    Aim: Relative adrenal insufficiency (RAI) has been reported in critically ill patients with cirrhosis. We evaluated the prevalence of RAI and its relationship to clinical course in non-septic cirrhosis patients with ascites.

    Methods: The study included 66 consecutive non-septic cirrhosis patients with ascites. Read More

    Clinical characteristics of acute encephalopathy with acute brain swelling: A peculiar type of acute encephalopathy.
    Brain Dev 2018 Jun 7. Epub 2018 Jun 7.
    Department of Pediatrics, Aizenbashi Hospital, Osaka, Japan.
    Objectives: Acute encephalopathy has been observed with acute brain swelling (ABS) that is characterized by rapid progression to whole-brain swelling. The objective of this study was to describe the clinical characteristics of ABS.

    Methods: We encountered four patients with ABS and retrospectively investigated their clinical data with a medical chart review. Read More

    [TURP syndrome: about a case].
    Pan Afr Med J 2017 17;28:243. Epub 2017 Nov 17.
    Service de Réanimation Polyvalente A4, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.
    We report the case of a 78-year old patient, with no particular past medical history, who underwent transurethral resection of the prostate (50 g) under spinal anesthesia for benign hypertrophy. 90 minutes after the beginning of the procedure, the patient had nausea, vomiting, visual fog and bradycardia, suggesting TURP syndrome. Ionogramme objectified a serum sodium level of 118meq/L, hence the patient was treated with 3% hypertonic saline solution, with good evolution. Read More

    The Impact of Albumin Use on Resolution of Hyponatremia in Hospitalized Patients With Cirrhosis.
    Am J Gastroenterol 2018 Jun 8. Epub 2018 Jun 8.
    University of Pennsylvania, Philadelphia, PA, USA.
    Objectives: Hyponatremia is associated with poor outcomes in cirrhosis independent of MELD. While intravenous albumin has been used in small series, its role in hyponatremia is unclear. The aim of this study is to determine the effect of albumin therapy on hyponatremia. Read More

    Legionella Pneumonia Complicated with Acquired Fanconi Syndrome: A Case Report.
    Intern Med 2018 Jun 6. Epub 2018 Jun 6.
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Japan.
    Legionella pneumonia is occasionally accompanied by renal complications; however, the cause of this remains unknown. We herein report a 70-year-old Japanese man with Legionella pneumonia who presented with hyponatremia, hypophosphatemia, and hypouricemia. The levels of urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase were remarkably high, indicating severe renal tubular damage. Read More

    Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia.
    Clin J Am Soc Nephrol 2018 Jun 5. Epub 2018 Jun 5.
    Department of Nephrology, Geisinger Medical Center, Danville, Pennsylvania; and
    Background And Objectives: Rapid correction of severe hyponatremia can result in serious neurologic complications, including osmotic demyelination. Few data exist on incidence and risk factors of rapid correction or osmotic demyelination.

    Design, Setting, Participants, & Measurements: In a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017, we examined the incidence and risk factors of rapid correction and osmotic demyelination. Read More

    A case series study of hypopituitarism in older patients with and without gastrointestinal symptoms.
    Postgrad Med 2018 Jun 4:1-6. Epub 2018 Jun 4.
    c Department of Endocrinology , First Affiliated Hospital of Dalian Medical University , Dalian , China.
    Objectives: Some older individuals who present with gastrointestinal symptoms as their chief complaint were ultimately diagnosed with hypopituitarism instead of gastrointestinal diseases. The aim of this study was to find the characteristics of biochemical indicators in these patients so as to reduce early misdiagnosis.

    Methods: We conducted a retrospective review of 45 patients with hypopituitarism who were at least 60 years of age. Read More

    Hyponatremia associates with poor outcome in metastatic renal cell carcinoma patients treated with everolimus: prognostic impact.
    Acta Oncol 2018 Jun 4:1-6. Epub 2018 Jun 4.
    b Department of Oncology , Aarhus University Hospital , Palle , Denmark.
    Background: The prognostication of metastatic renal cell carcinoma (mRCC) is based on Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk classifications. Research has shown that hyponatremia is associated with worse prognosis in cancer. We analyzed the association of hyponatremia and outcome in everolimus-treated mRCC patients. Read More

    Analysis of clinical features and early warning indicators of death from severe fever with thrombocytopenia syndrome.
    Int J Infect Dis 2018 May 30. Epub 2018 May 30.
    Yantai Center for Disease Control and Prevention, Yantai, Shandong 264003, PR China. Electronic address:
    Objective: To understand clinical features of confirmed cases from severe fever with thrombocytopenia syndrome (SFTS) and to explore the early warning index of SFTS death.

    Methods: A retrospective case-control study at a single medical institution in Yantai. A total of 20 SFTS patients who died (death group) during January 2014 to December 2015and another 40 age- and gender-matched SFTS patients who survived (survivor group) were identified from the case records. Read More

    Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review.
    Chonnam Med J 2018 May 25;54(2):101-112. Epub 2018 May 25.
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
    Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies, including meta-analyses, naturalistic studies, and longer-term studies suggested that SSRIs and SNRIs are no less safe than TCAs. We focused on comparing the common side effects of TCAs with those of newer generation antidepressants including SSRIs, SNRIs, mirtazapine, and bupropion. Read More

    Choosing Wisely in pediatric anesthesia: An interpretation from the German Scientific Working Group of Paediatric Anaesthesia (WAKKA).
    Paediatr Anaesth 2018 May 30. Epub 2018 May 30.
    Clinic for Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
    Inspired by the Choosing Wisely initiative, a group of pediatric anesthesiologists representing the German Working Group on Paediatric Anaesthesia (WAKKA) coined and agreed upon 10 concise positive ("dos") or negative ("don'ts") evidence-based recommendations. (i) In infants and children with robust indications for surgical, interventional, or diagnostic procedures, anesthesia or sedation should not be avoided or delayed due to the potential neurotoxicity associated with the exposure to anesthetics. (ii) In children without relevant preexisting illnesses (ie, ASA status I/II) who are scheduled for elective minor or medium-risk surgical procedures, no routine blood tests should be performed. Read More

    Mechanistic Target of Rapamycin (mTOR): Integrating Growth Factor and Nutrient Signaling in the Collecting Duct.
    Am J Physiol Renal Physiol 2018 May 30. Epub 2018 May 30.
    Medicine, Georgetown University, United States.
    The renal collecting duct and other post-macula densa sites are the primary tubular regions for fine-tuning of electrolyte homeostasis in the body. A role for the mechanistic target of rapamycin (mTOR), a serine-threonine kinase, has recently been appreciated as playing a central role in this regulation. mTOR exists in two distinct multi-protein functional complexes, i. Read More

    Pitfalls in SIADH-diagnosed hyponatraemia: Report of two cases.
    Neth J Med 2018 May;76(4):190-193
    Department of Internal Medicine, OLVG-West, Amsterdam, the Netherlands.
    In the majority of hospitalised patients with hyponatraemia, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the primary cause. Before considering SIADH, adrenal, thyroid and pituitary insufficiency should be ruled out. However, the evaluation of these contains potential pitfalls which could lead to incorrect diagnosing of SIADH. Read More

    Randomized, phase I/II study of gemcitabine plus IGF-1R antagonist (MK-0646) versus gemcitabine plus erlotinib with and without MK-0646 for advanced pancreatic adenocarcinoma.
    J Hematol Oncol 2018 May 30;11(1):71. Epub 2018 May 30.
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX, 77030, USA.
    Background: Binding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates downstream signals that activate PI3K/Akt/mTOR and MEK/Erk pathways, which stimulate cancer cell proliferation and induce drug resistance. Cross talk between IGF-1R and epidermal growth factor receptor (EGFR) mediates resistance to anti-EGFR agents. We studied safety, tolerability, and outcomes of MK-0646, IGF-1 monoclonal antibody, in combination with gemcitabine (G) ± erlotinib (E) in metastatic pancreatic cancer. Read More

    Strength in Numbers: A Team-Based Approach to Managing Patients with Hyponatremia.
    Am J Med 2018 May 24. Epub 2018 May 24.
    Nurse Practitioner, Nashville General Hospital Heart and Vascular Center, Instructor, Vanderbilt University School of Nursing, Nashville, TN.
    This virtual patient panel provides learners with real-world application of best practices among various members of the healthcare team in the management of patients with hyponatremia. A patient case is provided, followed by discussion among the team members to provide insight and context to why particular courses of action were chosen. (Online access: https://courses. Read More

    Outcomes Following Transsphenoidal Pituitary Surgery in the Elderly: A Retrospective Single-Center Review.
    Oper Neurosurg (Hagerstown) 2018 May 24. Epub 2018 May 24.
    Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California.
    Background: Transsphenoidal surgery (TSS) for pituitary adenomas (PAs) is performed on elderly patients with increasing frequency. More research is necessary to assess the risk factors that are associated with TSS in an aging population.

    Objective: To perform a retrospective study on postoperative safety outcomes following TSS in the elderly population stratified by decade of life. Read More

    Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India.
    J Trop Pediatr 2018 May 23. Epub 2018 May 23.
    Department of Pediatric Medicine, Institute of Postgraduate Medical Education & Research (I.P.G.M.E.& R.), 244, AJC Bose Road, 700020 Kolkata, India.
    Objective: The aim of this study was to assess the clinico-laboratory parameters, complications and therapeutic responses in children with scrub typhus in Eastern India.

    Materials And Methods: In this prospective, observational study, all children (age, <12 years) with suspected scrub typhus with a compatible clinical scenario were enrolled consecutively over six months. Cases confirmed by means of a positive IgM serology or a positive Weil-Felix reaction (OXK = 1/80 or above) were administered enteral doxycycline (4. Read More

    [Clinical research on perioperative restrictive fluid therapy combined with preoperative urination training in total hip arthroplasty].
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Nov;31(11):1295-1299
    Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,
    Objective: To evaluate the effectiveness and safety of restrictive fluid therapy combined with preoperative urination training during perioperative period in an enhanced recovery after surgery (ERAS) program for primary total hip arthroplasty (THA).

    Methods: A retrospective study were conducted in 73 patients who underwent unilateral THA with liberal intravenous fluid therapy on the day of surgery between April 2015 and March 2016 (control group) and in 70 patients with restrictive fluid therapy and preoperative urination training between November 2016 and April 2017 (trial group). There was no significant difference in gender, age, weight, height, body mass index, primary disease, and complications between 2 groups ( >0. Read More

    Strongyloides Hyperinfection and Miliary Tuberculosis Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Malnourished Patient.
    Cureus 2018 Mar 20;10(3):e2349. Epub 2018 Mar 20.
    Chair, Department of Medicine, Maimonides Medical Center.
    Strongyloides stercoralis (S. stercoralis) is an intestinal nematode endemic to tropical regions. An accelerated infection, known as a hyperinfection, occurs in immunocompromised patients, most commonly those treated chronically with glucocorticoids or those who have human T cell leukemia virus-1 (HTLV-1) infection. Read More

    Successful treatment by tolvaptan of the syndrome of inappropriate antidiuretic hormone secretion that may be associated with chemotherapy-induced tumour lysis in a patient with small-cell lung carcinoma.
    Respirol Case Rep 2018 Apr 26;6(3):e00296. Epub 2018 Jan 26.
    Second Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.
    Here, we report the case of a patient with small-cell lung carcinoma (SCLC) who developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This syndrome may be associated with chemotherapy-induced tumour lysis. Our patient was successfully treated with tolvaptan. Read More

    Antidiuretic hormone release associated with increased intracranial pressure independent of plasma osmolality.
    Brain Behav 2018 Jun 23;8(6):e01005. Epub 2018 May 23.
    Saint James School of Medicine-Anguilla, The Valley, Anguilla, British West Indies.
    Objective: Introduce and evaluate a new model which explains the release of brain antidiuretic hormone (ADH) independent of plasma osmolality.

    Methods: Systematic review and critical analysis of the professional literature.

    Results: Primary electronic database searches using key terms revealed 57,432 hits. Read More

    Endocrinopathy-induced euvolemic hyponatremia.
    Intern Emerg Med 2018 May 22. Epub 2018 May 22.
    Medicine A, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St, 49100, Petah-Tikva, Israel.
    Euvolemic hyponatremia results from either the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hypothyroidism, or adrenal insufficiency. Furthermore, the criteria for diagnosis of SIADH entail the exclusion of hypothyroidism and hypoadrenalism. We aim to assess the yield of euvolemic hyponatremia workup focusing on underlying endocrinopathies in a real-world setting. Read More

    Prevalence of electrolyte disturbances in perinatal asphyxia: a prospective study.
    Ital J Pediatr 2018 May 21;44(1):56. Epub 2018 May 21.
    Department of Pediatrics and Adolescent Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal.
    Background: Birth asphyxia is defined as the presence of hypoxia, hypercapnia, and acidosis leading the newborn to systemic disturbances probably electrolyte disturbance also. Knowledge of these electrolyte disturbances is very valuable as it can be an important parameter affecting perinatal morbidity, mortality and ongoing management.

    Methods: Serum sodium, potassium and ionized calcium of asphyxiated term newborn were sent within one hour of birth as per the inclusion criteria. Read More

    [Predictive significance of disturbed water-salt homeostasis in decompensated chronic heart failure patients].
    Kardiologiia 2018 SApr(S4):10-21
    State Budgetary Institution of Health Care, "Municipal Clinical Hospital #24 of the Moscow Department of Health Care".
    Aim: To estimate association between disorders of salt-water homeostasis on admision and the remote one-year prognosis for patients hospitalized with decompensated CHF NYHA FC III-IV.

    Materials And Methods: This prospective study was based on clinical amnestic data and results of one-year follow-up of 111 consecutive patients admitted for decompensation of CHF to the State Clinical Hospital No. 24 in January 2015‑February 2016. Read More

    The Efficacy and Safety of Long-term Pirfenidone Therapy in Patients with Idiopathic Pulmonary Fibrosis.
    Intern Med 2018 May 18. Epub 2018 May 18.
    Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan.
    Objective Pirfenidone (PFD) is often used for years, but the efficacy and safety of long-term PFD therapy in patients with idiopathic pulmonary fibrosis (IPF) are not fully understood. Methods and Patients We retrospectively evaluated 46 patients with IPF who received PFD between February 2009 and August 2014. The efficacy and safety of PFD therapy were compared between 2 groups: long-term therapy patients who received PFD for over 1 year (group L, n=30, 65%) and short-term therapy patients who could not receive PFD for more than 1 year due to worsening of their condition or side effects (group S, n=16, 35%). Read More

    Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke's cleft cysts.
    J Neurosurg 2018 May 18:1-7. Epub 2018 May 18.
    Department of Neurological Surgery, and.
    OBJECTIVE Rathke's cleft cysts (RCCs) are benign epithelial lesions of the sellar region typically treated via a transsphenoidal approach with cyst fenestration and drainage. At present, there is limited evidence to guide patient selection for operative treatment. Furthermore, there is minimal literature describing factors contributing to cyst recurrence. Read More

    [Antidepressive agents and hyponatremia: A literature review and a case/non-case study in the French Pharmacovigilance database].
    Therapie 2018 Mar 1. Epub 2018 Mar 1.
    Département de pharmacologie médicale, université Lille Nord-de-France, 59045 Lille cedex, France.
    Objective: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. Read More

    Potential role of peroxisome proliferator activated receptor gamma activation on serum visfatin and trace elements in high fat diet induced type 2 diabetes mellitus.
    Life Sci 2018 Jul 14;205:164-175. Epub 2018 May 14.
    Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.
    Aims: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin.

    Materials And Methods: Wistar rats were categorized into five groups. Read More

    Pathogenesis of cerebral edema in patients with acute renal and liver failure and the role of the nephrologist in the management.
    Curr Opin Nephrol Hypertens 2018 Jul;27(4):289-297
    Divisions of Nephrology and Critical Care Medicine, Department of Internal Medicine, UT Southwestern, Dallas, Texas, USA.
    Purpose Of Review: Acute liver failure (ALF) is a severe and complex illness and one of the most daunting conditions managed in the ICU. Because the renal care is intertwined with multiple disciplines, the aim of this review is to examine the multifactorial pathogenesis of cerebral edema in ALF, covering basic established facts as well as recent advances in our understanding of this condition.

    Recent Findings: Acetaminophen remains the most common cause of ALF in the United States and many European countries. Read More

    Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses.
    J Vet Intern Med 2018 May 17. Epub 2018 May 17.
    Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
    Background: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics.

    Objectives: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse.

    Animals: Six healthy adult mares. Read More

    2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes.
    Phys Sportsmed 2018 May 28:1-6. Epub 2018 May 28.
    b Department of Cardiology, Bispebjerg and Frederiksberg Hospitals , University of Copenhagen , Copenhagen , Denmark.
    Objectives: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion.

    Methods: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline [Formula: see text]Omax 48 ± 5 ml·kg·min) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Read More

    Sodium levels during hospitalization with acute myocardial infarction are markers of in-hospital mortality: Soroka acute myocardial infarction II (SAMI-II) project.
    Clin Res Cardiol 2018 May 15. Epub 2018 May 15.
    Cardiology Department, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
    Objective: Abnormalities in sodium homeostasis are common in hospitalized patients. Hyponatremia upon admission is a poor prognostic marker in acute myocardial infarction (AMI) patients. However, little is known about the association between changes in sodium levels and in-hospital mortality. Read More

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