13,843 results match your criteria Hyponatremia


Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis (SIAD).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel, Switzerland.

Copeptin is secreted in an equimolar amount to arginine vasopressin (AVP) but can easily be measured in plasma or serum with a sandwich immunoassay. The main stimuli for copeptin are similar to AVP, i.e. Read More

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http://dx.doi.org/10.1111/cen.13991DOI Listing

Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease.

Med Sci (Basel) 2019 Apr 18;7(4). Epub 2019 Apr 18.

Department of Pediatric Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 99191-91778, Iran.

The present study was performed to evaluate the clinical symptoms and cardiovascular complications in patients with typical and atypical Kawasaki disease (KD). This retrospective study was conducted on the medical records of 176 patients with KD for three years. The study population was divided into two groups of typical and atypical based on the KD clinical criteria. Read More

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http://dx.doi.org/10.3390/medsci7040063DOI Listing

Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine.

Korean J Pediatr 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.

Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported to be rare. The aim of this study was to investigate the rate and types of hematologic side effects of OXC. Read More

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http://dx.doi.org/10.3345/kjp.2019.00017DOI Listing

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing
March 2019
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The unmasking of hidden severe hyponatremia after long-term combination therapy in exacerbated bipolar patients: a case series.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.

Hyponatremia is occasionally unmasked in psychiatric patients during hospitalization after routine blood and urinary tests, and correlates in most cases with an inappropriate secretion of antidiuretic hormone, mainly due to iatrogenic factors. Only a few studies have regarded the combination of psychotropic drugs as triggers of chronic, asymptomatic hyponatremia in bipolar patients, who require to be hospitalized because of the exacerbation of their mental illness. We presented three clinical cases of patients affected by a long-term psychiatric disorder and under polypharmacotherapy for several months. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000265DOI Listing
April 2019
1 Read

Tension hydrothorax secondary to small cell lung cancer.

Respirol Case Rep 2019 Jul 6;7(5):e00420. Epub 2019 Apr 6.

Department of Surgery Dartmouth Hitchcock Medical Center Lebanon New Hampshire USA.

Malignant tension hydrothorax is rare. Here we present a malignant tension hydrothorax secondary to small cell lung cancer (SCLC). To our knowledge, this is the first report of this entity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcr2.420
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http://dx.doi.org/10.1002/rcr2.420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451749PMC
July 2019
2 Reads

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing
April 2019
1 Read

Hyponatremia in the perioperative period: When and how to correct.

Clin Liver Dis (Hoboken) 2017 May 26;9(5):111-114. Epub 2017 May 26.

Department of Anesthesia and Critical Care Medicine Mayo Clinic.

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http://doi.wiley.com/10.1002/cld.630
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http://dx.doi.org/10.1002/cld.630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467151PMC
May 2017
2 Reads

Predictors of outcomes in patients with ascites, hyponatremia, and renal failure.

Clin Liver Dis (Hoboken) 2013 Jun 21;2(3):132-135. Epub 2013 Jun 21.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN.

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http://dx.doi.org/10.1002/cld.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448637PMC

Hypervolemic hyponatremia: Clinical significance and management.

Clin Liver Dis (Hoboken) 2013 Jun 21;2(3):109-112. Epub 2013 Jun 21.

Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1002/cld.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448632PMC
June 2013
1 Read

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
2 Reads

A-scan ultrasonography to detect intracranial hypertension in patients with hyponatremia.

Am J Emerg Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1016/j.ajem.2019.04.009DOI Listing

A comparison of simple reaction times in psychotic inpatients with and without hyponatremia.

Schizophr Res 2019 Apr 13. Epub 2019 Apr 13.

Translational Neuroscience, Conshohocken, PA 19428, USA; Drexel University College of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.schres.2019.04.001DOI Listing

Clinical characteristics of autoimmune GFAP astrocytopathy.

J Neuroimmunol 2019 Apr 9;332:91-98. Epub 2019 Apr 9.

Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

The clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy remain to be elucidated. We describe here the clinical features of 14 patients with GFAP astrocytopathy confirmed by detection of GFAP-IgG in cerebrospinal fluid (CSF). The novel findings of this study are as follows. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.004DOI Listing
April 2019
1 Read

A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome.

Iran J Kidney Dis 2019 Mar;13(2):132-133

University of Health Sciences, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

McKittrick-Wheelock syndrome is a rare complication of rectosigmoid villous adenoma leading to secretory diarrhea, prerenal acute kidney injury and severe fluid and electrolyte imbalances. There are about 50 cases reported in literature. We represent a case of 71 year-old patient with persistant chronic diarrhea, prerenal azotemia, severe hypokalemia, and hyponatremia. Read More

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March 2019
2 Reads

Pathogenesis and clinical features of the acute hepatic porphyrias (AHPs).

Mol Genet Metab 2019 Mar 6. Epub 2019 Mar 6.

Section on Gastroenterology & Hepatology, Wake Forest University School of Medicine/NC Baptist Hospital, Winston-Salem, NC 27157, United States of America.

The acute hepatic porphyrias include four disorders: acute intermittent porphyria [AIP], hereditary coproporphyria [HCP], variegate porphyria [VP], and the rare porphyria due to severe deficiency of ALA dehydratase [ADP]. In the USA, AIP is the most severe and most often symptomatic. AIP, HCP, and VP are due to autosomal dominant genetic abnormalities, in which missense, nonsense, or other mutations of genes of normal hepatic heme biosynthesis, in concert with other environmental, nutritional, hormonal and genetic factors, may lead to a critical deficiency of heme, the end-product of the pathway, in a small but critical 'regulatory pool' within hepatocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192193008
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http://dx.doi.org/10.1016/j.ymgme.2019.03.002DOI Listing
March 2019
2 Reads

Pediatric Emergency Medicine Simulation Curriculum: Hyponatremic Seizures.

MedEdPORTAL 2016 Nov 10;12:10498. Epub 2016 Nov 10.

Co-Director of Pediatric Emergency Medicine Simulation, Seattle Children's Hospital; Associate Professor of Emergency Medicine, University of Washington School of Medicine.

Introduction: Seizures are a common complaint in the pediatric emergency department. Effective care of this potentially life-threatening medical emergency requires the ability to stabilize the patient while simultaneously identifying and treating the underlying cause. This simulation-based curriculum involves the identification and management of a generalized seizure in a 4-month-old infant secondary to hyponatremia. Read More

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https://www.mededportal.org/publication/10498
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http://dx.doi.org/10.15766/mep_2374-8265.10498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440407PMC
November 2016
2 Reads

Hyponatremia secondary to severe atopic dermatitis in early infancy.

Pediatr Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: Infants with atopic dermatitis who developed hyponatremia and hyperkalemia with raised aldosterone level have been repeatedly described in Japanese domestic literatures. However, similar reports from other countries are scarce.

Methods: Including our experiences, we collected reports of atopic dermatitis complicated with hyponatremia (≤130 mEq/L), written either in English or in Japanese, to delineate the characteristics and to elucidate the pathophysiology of this condition. Read More

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http://dx.doi.org/10.1111/ped.13865DOI Listing
April 2019
3 Reads

Risk Analysis of Perioperative Death in Lung Transplant Patients With Severe Idiopathic Pulmonary Hypertension.

Transplant Proc 2019 Apr 8;51(3):875-879. Epub 2019 Jan 8.

Department of Lung Transplantation, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China. Electronic address:

Objective: To investigate the risk factors for perioperative mortality in patients with severe idiopathic pulmonary hypertension (IPAH) undergoing lung transplantation (LTx).

Methods: Twenty-two IPAH patients were included in the study and were divided 2 groups: a case group with early death post LTx (n = 5, 22.7%) and the remaining 17 recipients (87. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.024DOI Listing
April 2019
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Association of Hyponatraemia and Antidepressant Drugs: A Pharmacovigilance-Pharmacodynamic Assessment Through an Analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS) Database.

CNS Drugs 2019 Apr 11. Epub 2019 Apr 11.

Pharmacovigilance Service, Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences L. Sacco, "Luigi Sacco" University Hospital, University of Milan ASST Fatebenefratelli-Sacco, Via G. B. Grassi, 74, 20157, Milan, Italy.

Background: Hyponatraemia induced by antidepressant drugs is a rare but potentially life-threatening adverse reaction. Whether it is associated with all or only some antidepressant drugs is still unclear. This needs to be clarified to guide antidepressant therapies, especially in patients with electrolytic imbalances. Read More

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http://dx.doi.org/10.1007/s40263-019-00631-5DOI Listing

Symptomatic Hyperglycemia in a Patient with Dialysis Ascites.

Am J Med Sci 2019 Feb 27. Epub 2019 Feb 27.

Division of Nephrology, Department of Medicine; Research Service, Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico. Electronic address:

An anuric woman with ascites rapidly developed extreme hyperglycemia and seizures after hemodialysis. During development of hyperglycemia, the decrease in serum sodium concentration (Δ[Na]) was nearly twice the value predicted by a formula accounting for the degree of hyperglycemia and the intracellular-to-extracellular volume ratio. The prediction assumed that ascitic fluid is part of the extracellular volume. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.016DOI Listing
February 2019
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Plasma electrolyte imbalance in pediatric kidney transplant recipients.

Pediatr Transplant 2019 Apr 11:e13411. Epub 2019 Apr 11.

Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background: In current practice, pediatric kidney transplant recipients receive large volumes of intravenous fluid intraoperatively to establish allograft perfusion, and further fluid to replace urinary and insensible losses postoperatively. Acute electrolyte imbalance can result, with potential for neurological sequelae. We aimed to determine the incidence and severity of postoperative plasma electrolyte imbalance in pediatric kidney transplant recipients managed with the current standard intravenous crystalloid regimen. Read More

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http://dx.doi.org/10.1111/petr.13411DOI Listing
April 2019
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Mediterranean spotted fever in the elderly: a prospective cohort study.

Eur J Clin Microbiol Infect Dis 2019 Apr 11. Epub 2019 Apr 11.

Infectious Diseases Unit, Internal Medicine Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Ctra. Torrebonica s/n, 08227, Terrassa, Spain.

The objective of this study is to evaluate the characteristics and outcome of elderly patients with Mediterranean spotted fever (MSF). This study was a prospective observational cohort study of all adult cases with confirmed MSF treated in a teaching hospital (1984-2015) to compare the characteristics of elderly patients (> 65 years) with younger adults. We identified 263 adult patients with MSF, and 53 (20. Read More

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http://dx.doi.org/10.1007/s10096-019-03558-3DOI Listing
April 2019
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Hyponatremia Following a Marathon, A Multifactorial Case with over Infusion of Fluids.

Curr Sports Med Rep 2019 Apr;18(4):115-117

Heller Institute of Medical Research, Sheba Medical Center, Ramat Gan, ISRAEL.

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http://dx.doi.org/10.1249/JSR.0000000000000580DOI Listing
April 2019
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Albumin in Cirrhosis: More Than a Colloid.

Curr Treat Options Gastroenterol 2019 Apr 9. Epub 2019 Apr 9.

Division of Nephrology (Kidney-Liver Program), Department of Medicine, University of Washington, 356521, 1959 NE Pacific Street, Seattle, WA, 98195-6521, USA.

Purpose Of Review: Albumin has repeatedly been shown to be beneficial in treating patients with decompensated cirrhosis. We reviewed the medical literature regarding indications for the use of intravenous albumin in cirrhosis, with particular focus on the ways in which albumin can help mitigate hepatorenal physiology.

Recent Findings: Albumin has long been used as the preferred agent for volume expansion in patients with decompensated cirrhosis. Read More

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http://dx.doi.org/10.1007/s11938-019-00227-4DOI Listing
April 2019
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Association of Hyponatremia and Risk of Short- and Long-Term Mortality in Patients with Stroke: A Systematic Review and Meta-Analysis.

J Stroke Cerebrovasc Dis 2019 Apr 6. Epub 2019 Apr 6.

Department of Neurology, Aviation General Hospital, Beijing, China. Electronic address:

Background: Hyponatremia is the most common electrolyte disorder in the clinic practice and it is closely related to the prognosis of various diseases. Studies reported that hyponatremia increased the risk of stroke mortality while yielded inconsistent findings during the follow-up period. Thus, a systematic review and meta-analysis to assess the relationship between hyponatremia and the short-term (within 90 days) and long-term (more than 1 year) prognosis of stroke patients was conducted. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.021DOI Listing
April 2019
1 Read

Improvement of hyponatremia in cirrhosis is associated with improved complex information processing.

J Gastroenterol Hepatol 2019 Apr 9. Epub 2019 Apr 9.

Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), and Centro de Investigaciones en Red Hepatologia y Digestivas (CIBEReHD), Barcelona, Spain.

Background And Aim: Hyponatremia, a cause of brain dysfunction and risk factor for hepatic encephalopathy, is frequent in patients with advanced cirrhosis and ascites. The interdependence of liver failure and hyponatremia makes it difficult to separate the effects of each on cognitive function. The objective was to assess whether an increase in plasma sodium in patients with cirrhosis and ascites leads to an improvement in cognitive function. Read More

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http://dx.doi.org/10.1111/jgh.14683DOI Listing
April 2019
1 Read

GNAS: A New Nephrogenic Cause of Inappropriate Antidiuresis.

J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Department of Renal Medicine, University College London, London, United Kingdom; and.

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http://dx.doi.org/10.1681/ASN.2019020143DOI Listing
April 2019
1 Read

Transient pseudohypoaldosteronism: a potentially severe condition affecting infants with urinary tract malformation.

J Pediatr Urol 2019 Mar 9. Epub 2019 Mar 9.

Department of Pediatric Urology, CHU Amiens, France.

Background: Secondary pseudohypoaldosteronism (S-PHA) is a life-threatening condition affecting young children with urinary tract malformation (UTM).

Objective: The aim of the study was to highlight the diagnosis of S-PHA in children with UTM and propose appropriate management.

Study Design: The authors retrospectively reviewed cases of S-PHA related to UTM observed at the institution and searched the PubMed® database to review the literature. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.002DOI Listing
March 2019
1 Read

Treatment of gynecomastia with prednisone: case report and literature review.

J Int Med Res 2019 Apr 8:300060519840896. Epub 2019 Apr 8.

contributed equally to this work.

This study aimed to report a unique case of primary adrenal insufficiency that was accompanied by painful gynecomastia, which was resolved by treatment with prednisone. Enlargement of the left breast with continuous weakness and generalized nausea in a male was discovered 3 months before admission. Magnetic resonance imaging of the brain was normal 1 month before presentation. Read More

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http://dx.doi.org/10.1177/0300060519840896DOI Listing
April 2019
5 Reads

Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.

Med Pharm Rep 2019 Jan 15;92(1):36-42. Epub 2019 Jan 15.

Internal Medicine Department, Pt. BD Sharma PGIMS, Rohtak, India.

Introduction: Scrub typhus is an acute febrile illness caused by . It is characterised by fever, rash, myalgia and diffuse lymphadenopathy. Most common complications are sepsis, shock, acute respiratory distress syndrome (ARDS), hepatitis, pre renal azotemia and multi organ dysfunction syndrome (MODS). Read More

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http://dx.doi.org/10.15386/cjmed-1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448495PMC
January 2019
4 Reads

Mirror writing after perimesencephalic subarachnoid haemorrhage.

J Clin Neurosci 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, University of Melbourne, Victoria, Australia.

We report a case of a right-handed Caucasian woman who developed mirror writing following a non-aneurysmal, non-traumatic subarachnoid haemorrhage. The patient was unaware of having this phenomenon, and it was detected by clinical staff when the patient was writing a card to a family member. Serial imaging has ruled out a stroke as well as an underlying vascular abnormality. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.039DOI Listing
April 2019
1 Read

A Healthy Toddler With Fever and Lethargy.

Pediatrics 2019 Apr 5. Epub 2019 Apr 5.

Division of Hospital Medicine and

A 21-month-old previously healthy girl presented to the emergency department initially with fever, rhinorrhea, and poor oral intake. She was subsequently discharged from the hospital on amoxicillin for treatment of acute otitis media but presented hours later on the same day with continued poor oral intake, decreased urine output, and lethargy. The patient was afebrile on examination without a focal source of infection or evidence of meningismus, but she was lethargic and minimally responsive to pain and had reduced strength in the upper and lower extremities. Read More

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http://dx.doi.org/10.1542/peds.2018-0412DOI Listing
April 2019
1 Read

A rare iatrogenic association of syndrome of inappropriate secretion of antidiuretic hormone, neuroleptic malignant syndrome and rhabdomyolysis.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz010. Epub 2019 Mar 29.

1U.O.C di Medicina Generale e Lungodegenza.

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered the prevalent cause of hyponatremia in hospitalized patients. Neuroleptic malign syndrome (NMS) is an idiosyncratic drug reaction showing fever, dysautonomia and rigidity with increased levels of Creatinine-phosphokinase (CPK) dependent on leakage of muscle contents into the circulation and defined as rhabdomyolysis. Although different diagnostic criteria for NMS have been established, it should be recognized that atypical presentations occur, particularly during treatment with atypical antipsychotics. Read More

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http://dx.doi.org/10.1093/omcr/omz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440259PMC
March 2019
2 Reads

Renal insufficiency in acute heart failure: old habits we need to let go?

Authors:
Gennaro Cice

Eur Heart J Suppl 2019 Mar 29;21(Suppl B):B38-B42. Epub 2019 Mar 29.

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Roma, Italy.

Heart failure and renal insufficiency often coexist in the same patient. Customarily, this condition is described as 'cardio-renal syndrome'. In this situation mortality increases significantly as the renal dysfunction worsen. Read More

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http://dx.doi.org/10.1093/eurheartj/suz027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439925PMC
March 2019
3 Reads

Small intestinal perforation due to a huge gastrointestinal stromal tumor in a kidney transplant recipient: a case report and literature review.

BMC Nephrol 2019 Apr 3;20(1):120. Epub 2019 Apr 3.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant recipient with perforation of small intestine.

Case Presentation: A 64-year-old male presented at our hospital with right colic pain; he had received an ABO incompatible kidney transplant 6 years earlier and was treated with cyclosporine, mycophenolate mofetil, and methylprednisolone. Read More

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http://dx.doi.org/10.1186/s12882-019-1310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448240PMC
April 2019
3 Reads

Nutrition for Ultramarathon Running: Trail, Track, and Road.

Int J Sport Nutr Exerc Metab 2019 Mar 3;29(2):130-140. Epub 2019 Apr 3.

4 Veteran Affairs Northern California Health Care System.

Ultramarathon running events and participation numbers have increased progressively over the past three decades. Besides the exertion of prolonged running with or without a loaded pack, such events are often associated with challenging topography, environmental conditions, acute transient lifestyle discomforts, and/or event-related health complications. These factors create a scenario for greater nutritional needs, while predisposing ultramarathon runners to multiple nutritional intake barriers. Read More

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http://dx.doi.org/10.1123/ijsnem.2018-0255DOI Listing
March 2019
2 Reads

Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 30;93:149-160. Epub 2019 Mar 30.

Department of Psychology & Health Research Centre, University of Almería, Almería, Spain. Electronic address:

Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulnerability to developing compulsive-like drinking in SIP. Adult male Wistar rats were first trained in a spatial-discrimination serial reversal-learning task and in a reinforcer devaluation task to measure behavioral flexibility and habit formation, respectively. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.03.016DOI Listing
March 2019
2 Reads

Evaluation of Hyponatremia in Ischemic Stroke Patients in a Tertiary Care Hospital of Karachi, Pakistan.

Cureus 2019 Jan 21;11(1):e3926. Epub 2019 Jan 21.

Internal Medicine, Dow University of Health Sciences, Karachi, USA.

Introduction Electrolyte disturbances are commonly found in acute stroke settings. Hypernatremia, hyponatremia and hypokalemia are the commonest types of electrolyte disturbances. Data on electrolyte changes in neurological disorders like stroke is insufficient in Asia. Read More

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http://dx.doi.org/10.7759/cureus.3926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433087PMC
January 2019
2 Reads

Hyponatremia secondary to transient renal salt wasting (TRSW): A not so uncommon observation in the elderly
.

Clin Nephrol 2019 Apr 2. Epub 2019 Apr 2.

Aims: We attempted to classify 115 consecutive nonedematous hyponatremic patients according to their history and saline responsiveness. We hereby describe 6 out of them presenting a transient renal salt wasting (TRSW) state of unknown origin.

Materials And Methods: Six patients with an initial SNa of 126 ± 3 mEq/L were included in the study. Read More

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http://dx.doi.org/10.5414/CN109472DOI Listing
April 2019
1 Read

Hyponatremia Due to Secondary Adrenal Insufficiency.

Authors:
Anuj Sarma

J Assoc Physicians India 2019 Jan;67(1):85-86

Anaesthesist, Critical Care Specialist, Postdoctoral Diploma in Cardiology, Downtown Hospital, Guwahati, Assam.

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January 2019
2 Reads

Dysnatremia in extremely low birth weight infants is associated with multiple adverse outcomes.

J Perinatol 2019 Apr 1. Epub 2019 Apr 1.

Pediatrix Medical Group, San Antonio, TX, USA.

Objective: The objective of this study is to discern patterns of serum sodium in a broad cohort of extremely low birth weight (ELBW) infants and associate those patterns with hospital outcomes.

Study Design: Retrospective cohort study of ELBW infants from 323 neonatal intensive care units (NICUs) discharged from 2004 to 2014. We included patients who survived at least 7 days and had daily sodium levels available, and categorized infants by their minimum and maximum sodium levels. Read More

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http://dx.doi.org/10.1038/s41372-019-0359-0DOI Listing
April 2019
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Misconceptions and Barriers to the Use of Hypertonic Saline to Treat Hyponatremic Encephalopathy.

Front Med (Lausanne) 2019 15;6:47. Epub 2019 Mar 15.

Division of Nephrology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Hyponatremic encephalopathy is a potentially life-threatening condition with a high associated morbidity and mortality. It can be difficult to diagnose as the presenting symptoms can be non-specific and do not always correlate with the degree of hyponatremia. It can rapidly progress leading to death from transtentorial herniation. Read More

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http://dx.doi.org/10.3389/fmed.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428704PMC
March 2019
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Difficult-to-treat Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient with Secondary Central Nervous System Lymphoma.

Cureus 2019 Jan 17;11(1):e3905. Epub 2019 Jan 17.

Internal Medicine, Peterborough City Hospital, Peterborough, GBR.

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is defined as hyponatremia with inappropriately concentrated urine in a euvolemic patient. SIADH is associated with a wide spectrum of clinical conditions. In the hospital, hyponatremia carries significant mortality with a prolonged duration of inpatient stay. Read More

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http://dx.doi.org/10.7759/cureus.3905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426639PMC
January 2019
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Perioperative fluid management in children: can we sum it all up now?

Curr Opin Anaesthesiol 2019 Mar 28. Epub 2019 Mar 28.

Clinic of Anaesthesiology, KRH Klinikum Robert Koch, Gehrden, Germany.

Purpose Of Review: The composition and type of intravenous fluids during paediatric anaesthesia have been subjects of debates for decades. Errors in perioperative fluid management in children may lead to serious complications and a negative outcome. Therefore, in this review, historical and recent developments and recommendations for perioperative fluid management in children are presented, based on physiology and focused on safety and efficacy. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000727DOI Listing
March 2019
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Effect of Tolvaptan on the Prognosis in Patients with Hepatic Ascites.

Hepatol Res 2019 Mar 27. Epub 2019 Mar 27.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Aim: Despite accumulating evidence concerning the efficacy of tolvaptan in the treatment of body fluid retention or hyponatremia, the effect of tolvaptan on the prognosis of patients with hepatic ascites has not been fully investigated.

Methods: A total of 628 patients with hepatic ascites who were treated with diuretics (furosemide, spironolactone, or tolvaptan) between 2007 and 2017 were enrolled and divided into two groups: one in which patients received tolvaptan (original tolvaptan group, n=278) and the other in which they did not (original control group, n=350). The cumulative survival rates between the groups were compared and the factors associated with survival in patients with hepatic ascites were identified using a Cox regression analysis. Read More

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http://dx.doi.org/10.1111/hepr.13337DOI Listing
March 2019
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Contribution of geriatric model to the management of an epileptic seizure or epilepsy.

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):21-24

Centre de gériatrie, Pavillon Bottard et CMRR Paris-Sud, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France, DHU FAST, Sorbonne-Université, Paris, France.

Epileptic seizures and epilepsy appear frequent in the elderly. The diagnosis is often more difficult and therapeutic decisions are often debated. In this context, the implementation of a rigorous analysis and reasoning to correctly determine the various components at the origin of the epileptic seizure is fundamental. Read More

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http://dx.doi.org/10.1684/pnv.2019.0791DOI Listing
March 2019
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Multimorbidity and epilepsia in the elderly.

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):13-19

Pôle hospitalo-universitaire de gérontologie clinique, CHU Nantes, France.

Epilepsia is a frequent disease in the elderly. Most of the time seizures are the consequence of another or other comorbidities and they are generally partial. Causal pathologies are either cerebral or general. Read More

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http://dx.doi.org/10.1684/pnv.2019.0780DOI Listing
March 2019
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Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study.

Jpn J Clin Oncol 2019 Mar 27. Epub 2019 Mar 27.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Objectives: We conducted a Phase I/II study of carboplatin, S-1 and concurrent thoracic radiotherapy (TRT) for elderly patients (71 years or older) with unresectable stage III non-small cell lung cancer (NSCLC).

Materials And Methods: Patients received carboplatin (AUC 3-5) on Day 1 and S-1 (30-40 mg/m2 two times daily) on Days 1-14, every 2 weeks, for up to four cycles, plus concurrent TRT at a total dose of 60 Gy. The primary endpoint for the Phase II study was the 1-year progression-free survival (PFS) rate. Read More

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http://dx.doi.org/10.1093/jjco/hyz039DOI Listing
March 2019
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Medication and medical diagnosis as risk factors for falls in older hospitalized patients.

Eur J Clin Pharmacol 2019 Mar 26. Epub 2019 Mar 26.

Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, An der Lutter 24, 37075, Göttingen, Germany.

Objective: To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients.

Design: Matched case-control study.

Setting: Large regional hospital in a mid-sized German city. Read More

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http://dx.doi.org/10.1007/s00228-019-02668-3DOI Listing
March 2019
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