13,734 results match your criteria Hyponatremia


Successful management of severe hyponatremia in CKD-VD: In a cost limited setting.

Hemodial Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Patients with end stage renal disease (ESRD) and severe hyponatremia always pose a challenge to manage. It is necessary to correct biochemical parameters, advanced azotemia, and fluid overload with conventional haemodialysis (HD) but it may correct serum sodium (Na) rapidly resulting in neurological complications like seizures and osmotic demyelination syndrome. Continuous renal replacement therapy (CRRT) is an ideal modality to manage such patients. Read More

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http://dx.doi.org/10.1111/hdi.12716DOI Listing
February 2019

[The clinical importance of hyponatremia].

Orv Hetil 2019 Feb;160(8):314-319

II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6725.

Hyponatremia is a most common disorder of electrolytes encountered in everyday clinical practice. Although many cases are mild and relatively asymptomatic, hyponatremia is nonetheless important clinically because of the potential for substantial morbidity and mortality. Despite the knowledge of hyponatremia since the mid-20th century, this common disorder remains incompletely understood in many basic areas because of its causation by multiple etiologies with differing pathophysiological mechanisms. Read More

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http://dx.doi.org/10.1556/650.2019.31318DOI Listing
February 2019

Osmotic Demyelination Syndrome - Evolution of Extrapontine Before Pontine Myelinolysis on Magnetic Resonance Imaging.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):126-135

Department of Internal Medicine, Max Super Speciality Hospital, New Delhi, India.

Osmotic demyelination syndrome is a rare entity characterized by noninflammatory demyelination afflicting the central pons, basal ganglia, thalami, peripheral cortex, and hippocampi. Histopathologically, there is a destruction of myelin sheaths sparing the underlying neuronal axons due to the susceptibility of oligodendrocytes to rapid osmotic shifts often encountered in chronically debilitated patients. We present the temporal progression of signal abnormalities on sequential magnetic resonance imaging (MRI) scans in a middle-aged male initially presenting with altered mental status due to severe hyponatremia and subsequently developing rigidity, diagnosed as osmotic demyelination syndrome based on typical imaging findings and supportive laboratory parameters. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_240_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337981PMC
February 2019

Minimal/Covert Hepatic Encephalopathy - Impact of Comorbid Conditions.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):109-111. Epub 2018 Sep 17.

Clinic for Neurology, Hannover Medical School, Hannover, Germany.

Mild cognitive dysfunction as in minimal or covert hepatic encephalopathy (HE) can be found in a variety of metabolic disturbances, several neurological diseases, and even older age. Because liver cirrhosis usually is accompanied by one or the other of these, a differentiation between HE and cognitive decline because of comorbidities is difficult. Somehow discriminating is the impairment of motor speed and accuracy, which is more prominent in HE than in any of the comorbidities. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363959PMC
September 2018

Be aware of the effects of glucocorticoids on SIADH: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14295

Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Guangdong Province, China.

Rationale: Hyponatremia is one of the most common electrolyte disorders in clinic. Due to the complicated etiology and the nonspecific clinical manifestations, the diagnosis of hyponatremia is a complicated process. A variety of clinical disorders can cause inappropriately increased antidiuretic hormone (ADH) secretion, leading to inappropriate water retention and consequent hyponatremia. Read More

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http://dx.doi.org/10.1097/MD.0000000000014295DOI Listing
February 2019

Acute Severe Hyponatremia as a Serious Health Implication of Herbal Detox Regimens.

Cureus 2018 Dec 6;10(12):e3697. Epub 2018 Dec 6.

Internal Medicine, University of Kentucky School of Medicine, Lexington, USA.

Hyponatremia is a serious health problem and can cause substantial morbidity and mortality as a result of osmotically induced cerebral edema if left untreated. Also, inappropriate rapid correction of chronic cases of hyponatremia can lead to osmotic demyelination with neurological impairment and death as consequences. It is defined as a serum sodium concentration less than 135 mmol/L. Read More

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http://dx.doi.org/10.7759/cureus.3697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368431PMC
December 2018

[A case of cerebral salt wasting syndrome caused by minor head injury].

Nihon Ronen Igakkai Zasshi 2019 ;56(1):67-73

Department of Internal Medicine, Sankoukai Miyazaki Hospital.

An 80-year-old woman who was hospitalized due to small subarachnoid hemorrhaging caused by a bruise in the left temporal region of the brain. Nausea/vomiting and malaise appeared after dinner on the fourth day of the illness. Head computed tomography showed that the post-traumatic status was almost normal; however, the sodium ion (Na) level was 114 mEq/L, indicating severe hyponatremia. Read More

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http://dx.doi.org/10.3143/geriatrics.56.67DOI Listing
January 2019

Iatrogenic Takotsubo Cardiomyopathy Secondary to Norepinephrine by Continuous Infusion for Shock.

Eur J Case Rep Intern Med 2018 26;5(7):000894. Epub 2018 Jul 26.

Serviço de Medicina 1, Hospital do Espírito Santo Évora EPE, Évora, Portugal.

Takotsubo cardiomyopathy is a condition characterized by transient left ventricular systolic and diastolic dysfunction, with a possible direct causal role of catecholamine in its pathophysiology. We present a case of a woman with shock and adrenal insufficiency in whom Takotsubo cardiomyopathy developed after treatment with norepinephrine. This case confirms the direct causal role of catecholamine in the pathophysiology of Takotsubo cardiomyopathy. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/894
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http://dx.doi.org/10.12890/2018_000894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346780PMC
July 2018
1 Read

Electrolyte Disorders as Triggers for Takotsubo Cardiomyopathy.

Eur J Case Rep Intern Med 2018 24;5(4):000760. Epub 2018 Apr 24.

Internal Medicine Department, Brugmann University Hospital, Brussels, Belgium.

A 56-year-old woman presented with cognitive impairment, confusion and slowed speech, muscle cramps and peripheral paraesthesia preceded by vomiting. Blood tests revealed severe hypokalaemia, hyponatremia, hypomagnesemia and hypocalcaemia. Following a diagnosis of Takotsubo cardiomyopathy based on ultrasonography, the patient was treated with electrolyte supplementation and recovered within 48h. Read More

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http://dx.doi.org/10.12890/2018_000760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346755PMC

Serum sodium level variability as a prognosticator in older adults.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):632-638

a School of Medicine and Dentistry , University of Aberdeen , Aberdeen , UK.

Our aim was to explore biological variation of serum sodium levels as a method of quantifying health risk in older adults. We investigated whether dynamic changes in serum sodium levels could provide additional prognostic information to standard predictors of mortality in older people. Analysis of routinely collected clinical datasets containing information on demographics, hospitalisation, biochemistry, haematology and physical function for Dundee in-patient rehabilitation services, between 1999 and 2011. Read More

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http://dx.doi.org/10.1080/00365513.2018.1543893DOI Listing
February 2019

Hyponatremia Is Associated With Increased Osteoporosis and Bone Fractures in Patients With Diabetes With Matched Glycemic Control.

J Endocr Soc 2019 Feb 4;3(2):411-426. Epub 2019 Jan 4.

Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, District of Columbia.

Context: Patients with diabetes mellitus are at increased risk for bone fragility fracture secondary to multiple mechanisms. Hyperglycemia can induce true dilutional hyponatremia. Hyponatremia is associated with gait instability, osteoporosis, and increased falls and bone fractures, and studies suggest that compromised bone quality with hyponatremia may be independent of plasma osmolality. Read More

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http://dx.doi.org/10.1210/js.2018-00320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364625PMC
February 2019
1 Read

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
2 Reads

Higher Diuretic Requirements in Acute Heart Failure With Admission Hyponatraemia Versus Normonatraemia.

Heart Lung Circ 2019 Jan 28. Epub 2019 Jan 28.

Division of Cardiovascular Medicine, Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, KY, USA.

Background: Diuretic requirements in patients with acute decompensated heart failure (ADHF) and hyponatraemia versus normonatraemia on admission has not been previously explored.

Methods: The Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial dataset was utilised to examine the characteristics and diuretic requirements of patients with ADHF with hyponatraemia or normonatraemia on admission.

Results: Patients with ADHF and admission hyponatraemia (n = 103, average Na 130. Read More

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http://dx.doi.org/10.1016/j.hlc.2018.12.014DOI Listing
January 2019
2 Reads

Wilderness Neurology.

Semin Neurol 2019 Feb 11;39(1):137-148. Epub 2019 Feb 11.

Division of Emergency Medicine, Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont.

The study of wilderness medicine is within the scope of medical care in the austere environment and addresses medicine as practiced in the setting of delayed access to definitive medical care, hostile environment, limited equipment, and inherent risks to the patient and/or rescuers. Part of this topic includes the care of patients with neurologic illness and/or injury.We will address the five most important skills of a wilderness medicine professional: decision making, prevention, preparation, protocol development, and education by applying the principles to select common neurologic problems that occur in the extended environment: traumatic brain injury, dehydration, hyponatremia, heat illness, hypothermia, spine injury, and lightning injury. Read More

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http://dx.doi.org/10.1055/s-0038-1676994DOI Listing
February 2019
2 Reads

Hyponatremia could identify patients with intrabdominal sepsis and anastomotic leak after colorectal surgery: a systematic review of the literature.

Updates Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Colorectal Surgery, Chelsea and Westminster Hospital, 369 Fulham Rd, London, SW10 9NH, UK.

Anastomotic leak (AL) is a serious post-operative complication in colorectal surgery. It can lead to devastating morbidity and mortality. Clinicians usually depend on a combination of clinical, biochemical and radiological findings to diagnose this problem. Read More

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http://dx.doi.org/10.1007/s13304-019-00627-2DOI Listing
February 2019
1 Read

Emphysematous Pyelonephritis Following Ureterovesical Reimplantation for Congenital Obstructive Megaureter. Pediatric Case Report and Review of the Literature.

Front Pediatr 2019 24;7. Epub 2019 Jan 24.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing infection of the kidney. To date, very few cases of EPN have been described in the pediatric age. The first case of EPN in a toddler occurring after ureterovesical reimplantation for congenital obstructive megaureter is reported with a literature review. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00002/
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http://dx.doi.org/10.3389/fped.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354553PMC
January 2019
7 Reads

Bortezomib-induced hyponatremia: tolvaptan therapy permits continuation of lenalidomide, bortezomib and dexamethasone therapy in relapsed myeloma.

Exp Hematol Oncol 2019 1;8. Epub 2019 Feb 1.

1Academic Department of Haematology, Coleman Byrne Unit, Beaumont Hospital/RCSI Medical School, Dublin 9, Ireland.

The development of hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) is well recognised in multiple myeloma (MM). SIADH, due to either MM or Bortezomib can be hazardous as severe hyponatremia may develop if large volumes of hypotonic intravenous fluid are used as an adjunct to chemotherapy. We report a case of Bortezomib-induced SIADH, in whom the use of tolvaptan, a vasopressin receptor-2 antagonist, permitted the continuation of triple combination anti-MM therapy with lenalidomide, Bortezomib and dexamethasone (RVD) in a female with aggressive disease, without the development of hyponatremia. Read More

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http://dx.doi.org/10.1186/s40164-019-0128-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359864PMC
February 2019
1 Read

Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review.

BMC Neurol 2019 Feb 7;19(1):19. Epub 2019 Feb 7.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Background: Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturbances and hyponatremia. Antibody-LGI 1 autoimmune encephalitis (anti-LGI1 AE) has increasingly been recognized as a primary autoimmune disorder with favorable prognosis and response to treatment.

Case Presentation: Herein, we reported a male patient presenting as rapidly progressive dementia and hyponatremia. Read More

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http://dx.doi.org/10.1186/s12883-019-1251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366039PMC
February 2019
1 Read
2.040 Impact Factor

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
2 Reads

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer.

Invest New Drugs 2019 Feb 6. Epub 2019 Feb 6.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 353 E 68th St, New York, NY, 10065, USA.

Background Antibody drug conjugates (ADC) offer the potential of maximizing efficacy while minimizing systemic toxicity. ASG-5ME, an SLC44A4-targeting antibody carrying monomethyl auristatin E (MMAE), a microtubule-disrupting agent, was investigated in men with metastatic castration resistant prostate cancer. Methods The primary objective of this phase I study was to determine maximum tolerated dose (MTD) and recommended phase II dose. Read More

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http://dx.doi.org/10.1007/s10637-019-00731-5DOI Listing
February 2019
1 Read

Hyponatremia Presenting with Recurrent Mania.

Cureus 2018 Nov 28;10(11):e3645. Epub 2018 Nov 28.

Psychiatry, Frederick Memorial Hospital, Clear Spring, USA.

Primary psychogenic polydipsia (PPD) is a chronic, relapsing condition in which there is a disturbance in thirst control primarily due to an underlying disorder such as a psychogenic condition. It is characterized by an increase of fluid intake along with excretion of excessive amounts of dilute urine exceeding 40 to 50 mL/kg of body weight. PPD is typically seen in patients with schizophrenic symptoms due to elevated levels of dopamine that stimulate the thirst center or in patients with a psychiatric history receiving anticholinergic drugs. Read More

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https://www.cureus.com/articles/15871-hyponatremia-presentin
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http://dx.doi.org/10.7759/cureus.3645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351112PMC
November 2018
4 Reads

Delayed postoperative hyponatremia after endoscopic transsphenoidal surgery for pituitary adenoma.

Acta Neurochir (Wien) 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-0914, Japan.

Background: Hyponatremia generally occurs after transsphenoidal surgery (TSS) in a delayed fashion. Most patients with delayed postoperative hyponatremia (DPH) are asymptomatic or only express non-specific symptoms; consequently, DPH is associated with prolonged hospitalization. No consensus has been reached on which patients are at greatest risk of developing DPH. Read More

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http://dx.doi.org/10.1007/s00701-019-03818-3DOI Listing
February 2019
2 Reads

[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):105-113

Burdenko Neurosurgical Institute, Moscow, Russia.

The use of endoscopic technique has significantly extended the indications for surgery using the transsphenoidal approach. Currently, more than 90% of pituitary adenomas are operated on transsphenoidally. Transnasal removal of giant pituitary adenomas has become possible. Read More

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http://dx.doi.org/10.17116/neiro201882061105DOI Listing
January 2018
1 Read

THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

Division of Endocrinology and Metabolism, Georgetown University.

Objective: Hyponatremia decreases bone mineral density and a major risk factor for fragility fractures. Objectives of our systematic review and meta-analysis were to analyze the overall effects of hyponatremia on bone fractures, osteoporosis and mortality.

Methods: We extracted data from MEDLINE®, Cochrane Central, and EMBASE 1960-2017 and conference abstracts from 2007-2017. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0499
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http://dx.doi.org/10.4158/EP-2018-0499DOI Listing
January 2019
3 Reads

Impact of drugs on venous thromboembolism risk in surgical patients.

Eur J Clin Pharmacol 2019 Feb 5. Epub 2019 Feb 5.

Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1104, Ljubljana, Slovenia.

Purpose: This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE).

Results: Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Read More

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http://link.springer.com/10.1007/s00228-019-02636-x
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http://dx.doi.org/10.1007/s00228-019-02636-xDOI Listing
February 2019
4 Reads

Intravenous infusion of glucose 5% despite sodium mixed, is main contributor of acquired hyponatremia in adult polyvalent medicine service: Case control study.

Nephrol Ther 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal medicine and medical specialties, University of Health sciences of Libreville, Allée de Compiègne 3rd floor, apartment 13, 37000 Tours, France.

Background: Acquired hyponatremia is a life threatening event. Intravenous infusion of a mixture of 5% glucose and sodium solute is mainly used, but its contribution in the occurrence of acquired hyponatremia in adult, is under-investigated outside intensive care unit.

Objective: To evaluate the place of intravenous infusion of a mixture of 5% glucose and sodium in predicting acquired hyponatremia in adult polyvalent medicine service. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183065
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http://dx.doi.org/10.1016/j.nephro.2018.10.004DOI Listing
February 2019
5 Reads

Neonatal Hyponatremia in the Setting of Untreated Progressive Hydrocephalus: Case Report.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatric Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: Hyponatremia in the neonatal population is an uncommon occurrence and can be associated with significant increase in morbidity and mortality. In the neonatal population, it is typically associated with an excess of antidiuretic hormone (ADH) and rarely has been found to be associated with hydrocephalus short of being caused by the subsequent treatment of hydrocephalus.

Case: Description: We present a case report of a patient with neonatal hydrocephalus, secondary to intraventricular hemorrhage in the setting of prematurity, treated at our institution, in whom sodium levels reached a nadir as head circumference peaked and subsequent treatment of hydrocephalus resolved the associated hyponatremia. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.124DOI Listing
February 2019
1 Read

Impact of restricting fluid and sodium intake in term asphyxiated newborns treated with hypothermia.

J Matern Fetal Neonatal Med 2019 Feb 3:1-221. Epub 2019 Feb 3.

a Division of Newborn Medicine , Department of Pediatrics , McGill University , Montreal , Canada.

Aim: To study the consequences of restricting fluid and sodium intake in asphyxiated newborns treated with hypothermia.

Methods: We conducted a retrospective cohort study of asphyxiated newborns treated with hypothermia from 2009 to 2015. The fluid, parenteral nutrition and sodium as well as the urine produced per day were calculated. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1578747DOI Listing
February 2019
3 Reads

A loss of consciousness in a teenage girl with anorexia nervosa, due to polydipsia: case report and a minireview.

Eat Weight Disord 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics, Allergology and Gastroenterology, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University of Toruń, M. Curie Skłodowskiej 9, 85-094, Bydgoszcz, Poland.

Purpose: Anorexia nervosa is a chronic disease which may result in various complications. In pediatric clinical practice, it is common to observe complications related to progressive cachexia caused by malnutrition; however, cases of severe complications, like electrolyte disorders, which represent a direct threat to life, due to polydipsia, are rarely observed. The purpose of this study is to highlight that excessive drinking is of primary importance in anorexia nervosa patients, as it can result in severe medical complications, including increased risk of death. Read More

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http://link.springer.com/10.1007/s40519-018-00636-x
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http://dx.doi.org/10.1007/s40519-018-00636-xDOI Listing
February 2019
4 Reads

Anxiolytic treatment but not anxiety itself causes hyponatremia among anxious patients.

Medicine (Baltimore) 2019 Feb;98(5):e14334

Internal Medicine D, The Chaim Sheba Medical Center, Tel-Hashomer.

The aim of the study was to define whether anxiety itself or only the treatment with anxiolytic medication is risk factor for hyponatremia and overhydration.A case-control study of patients with a diagnosis of anxiety who received a selective serotonin reuptake inhibitor (SSRI). Serum sodium, urea to creatinine ratio, and odds ratio (OR) of hyponatremia and overhydration before initiation of treatment were compared to those of a control group of participants. Read More

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http://dx.doi.org/10.1097/MD.0000000000014334DOI Listing
February 2019
2 Reads

Congenital adrenal hyperplasia with salt-wasting crisis and arrhythmia: a case study.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Paediatrics, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

We report a case of a 10-day-old male infant who presented to the emergency department with severe electrolyte imbalance and life-threatening arrhythmia. The parents reported a 3-day history of poor feeding and lethargy. On examination, he was bradycardic (heart rate of 65 beats/min) with signs of dehydration. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22756
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http://dx.doi.org/10.1136/bcr-2018-227565DOI Listing
January 2019
20 Reads

Tolvaptan Use to Treat SIADH in a Child.

J Pediatr Pharmacol Ther 2018 Nov-Dec;23(6):494-498

Hyponatremia is one of the most common electrolyte abnormalities encountered in the clinical setting in hospitalized patients. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the leading cause of hyponatremia in most of these cases. While fluid restriction, hypertonic saline infusion, diuretics, and the treatment of underlying conditions constitute the first line of treatment of SIADH, in refractory cases, and especially for pediatric patients, there seems not to be any other choice for treatment. Read More

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http://www.jppt.org/doi/10.5863/1551-6776-23.6.494
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http://dx.doi.org/10.5863/1551-6776-23.6.494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336180PMC
January 2019
4 Reads

Hypocalcaemia and hyponatraemia masquerading the diagnosis of Gitelman syndrome.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Medicine, Kasturba Medical College Mangalore Affiliated to Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Gitelman syndrome is the most common renal tubulopathy, recently exhibiting a dramatic rise of incidence in Asia.A 50-year-old woman presented with vomiting, fatigue and quadriparesis. Physical examination revealed a positive Trousseau sign , hypotonia and areflexia. Read More

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http://dx.doi.org/10.1136/bcr-2018-227886DOI Listing
January 2019
1 Read

Predictors of ischemic bowel in patients with incarcerated hernias.

Hernia 2019 Jan 28. Epub 2019 Jan 28.

Division of Trauma, Surgical Critical Care and Acute Care Surgery, Department of Surgery, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA, 90502, USA.

Purpose: Diagnosing intestinal strangulation in the setting of incarcerated hernias remains challenging. Hyponatremia has been identified as a predictor of necrotizing soft tissue infections and gangrenous cholecystitis. We hypothesized that hyponatremia could predict bowel ischemia in patients with incarcerated hernias. Read More

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http://dx.doi.org/10.1007/s10029-019-01884-1DOI Listing
January 2019
1 Read

New fluid therapy protocol in acute burn from a tertiary burn care centre.

Burns 2019 Jan 24. Epub 2019 Jan 24.

Department of Burns, Plastic and Maxillofacial Surgery, Vardhaman Mahaveer Medical College and Safdarjang Hospital, New Delhi, 110 029, India.

Background: Ringer lactate is the main fluid for resuscitation of acute burns. However it is not a complete fluid alone, as it does not take care of sugar and electrolyte balance adequately. This study has been carried out to compare the use of Ringer lactate (RL) alone and combination of RL with Dextrose Normal Saline (DNS) as fluid replacement therapy in acute burn. Read More

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http://dx.doi.org/10.1016/j.burns.2018.03.011DOI Listing
January 2019
1 Read

High-Density Lipoprotein Cholesterol and Hyponatremia: An Unsolved Gordian Knot.

Am J Med 2019 Feb;132(2):e47-e48

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183096
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http://dx.doi.org/10.1016/j.amjmed.2018.10.010DOI Listing
February 2019
3 Reads

[Follow-up observation on short-term efficacy of low dose tolvaptan in the management of cirrhotic hyponatremia].

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):62-64

Department of Gastroenterology, Henan Province People's Hospital, Zhengzhou 450003, China.

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.01.014DOI Listing
January 2019
1 Read

The prognostic effects of hyponatremia and hyperchloremia on postoperative NSCLC patients.

Curr Probl Cancer 2019 Jan 17. Epub 2019 Jan 17.

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, PR China; Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, PR China. Electronic address:

Electrolytic disorders are common in lung cancer patients. But the association between serum electrolytes levels and survival in patients undergoing lung cancer resections for non-small-cell lung cancer (NSCLC) has been poorly investigated. A retrospective study was conducted on consecutive postoperative NSCLC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01470272183027
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http://dx.doi.org/10.1016/j.currproblcancer.2018.12.006DOI Listing
January 2019
11 Reads
1.000 Impact Factor

"A comparative study of bolus dose of hypertonic saline, mannitol and mannitol plus glycerol combination in patients with severe traumatic brain injury".

World Neurosurg 2019 Jan 23. Epub 2019 Jan 23.

Senior Consultant, Department of Neurosurgery, Aurobindo Hospital, Indore, Madhya Pradesh, India. 452010.

Introduction: This prospective randomized controlled study (RCT) compared the efficacy of an equiosmolar and isovolumetric dose of 3 % hypertonic saline, 20 % mannitol and 10 % mannitol plus 10 % glycerol combination in reducing the raised Intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI).

Methods: 120 patients of severe traumatic brain injury with increased ICP were randomized to receive an equiosmolar and isovolumetric dose of 3 % hypertonic saline, 20 % mannitol and 10 % mannitol plus 10 % glycerol combination at a defined infusion rate, which was stopped when ICP was < 15 mmHg.

Results: Total 120 patients with severe traumatic brain injury (aged >18 years, GCS ≤8 and had sustained elevated ICP of >20 mm Hg for more than 5 minutes) were randomized during the study. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.051DOI Listing
January 2019
3 Reads

Serotonin Syndrome with Atypical Hypernatremia.

Cureus 2018 Nov 19;10(11):e3616. Epub 2018 Nov 19.

Internal Medicine, West Virginia School of Osteopathic Medicine, Lewisburg, USA.

The incidence of serotonin syndrome in the United States is rising yearly. Providers should be aware of the useful diagnostic criteria and have a low threshold for utilizing such criteria to prevent increased morbidity and mortality. In this case, a 64-year-old female with a complex past medical history presented to the emergency department with an altered mental status after being found poorly responsive by her husband. Read More

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http://dx.doi.org/10.7759/cureus.3616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340410PMC
November 2018
1 Read

Practical document on the management of hyponatremia in critically ill patients.

Med Intensiva 2019 Jan 21. Epub 2019 Jan 21.

Unidad de Cuidados Intensivos, Hospital Regional Universitario Carlos Haya, Málaga, España.

Hyponatremia is the most prevalent electrolyte disorder in Intensive Care Units. It is associated with an increase in morbidity, mortality and hospital stay. The majority of the published studies are observational, retrospective and do not include critical patients; hence it is difficult to draw definitive conclusions. Read More

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http://dx.doi.org/10.1016/j.medin.2018.12.002DOI Listing
January 2019
1 Read

Ad libitum water consumption prevents exercise-associated hyponatremia and protects against dehydration in soldiers performing a 40-km route-march.

Mil Med Res 2019 01 25;6(1). Epub 2019 Jan 25.

Division of Kinesiology, Wayne State University, Detroit, MI, USA.

Background: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia (EAH) during prolonged exercise. The aim of this study was to determine the incidence of EAH within the broader context of fluid regulation among soldiers performing a 40-km route-march ingesting water ad libitum.

Methods: Twenty-eight healthy male soldiers participated in this observational trial. Read More

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http://dx.doi.org/10.1186/s40779-019-0192-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346586PMC
January 2019
2 Reads

Trametinib Toxicities in Patients With Low-grade Gliomas and Diabetes Insipidus: Related Findings?

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Division of Haematology/Oncology.

Low-grade gliomas (LGG) represent the most common form of primary central nervous system tumor arising in childhood. There is growing evidence to support the role of the mitogen-activated protein kinase pathway in driving tumor growth and MEK inhibitors are being investigated in clinical trials for refractory and unresectable LGGs. As MEK inhibitors progress through clinical trials, drug toxicities have been identified. Read More

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http://Insights.ovid.com/crossref?an=00043426-900000000-9764
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http://dx.doi.org/10.1097/MPH.0000000000001427DOI Listing
January 2019
8 Reads

Fluids and hyperosmolar agents in neurocritical care: an update.

Curr Opin Crit Care 2019 Jan 22. Epub 2019 Jan 22.

Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery Johns Hopkins School of Medicine, Baltimore Maryland. USA.

Purpose Of Review: To discuss recent updates in fluid management and use of hyperosmolar therapy in neurocritical care.

Recent Findings: Maintaining euvolemia with crystalloids seems to be the recommended fluid resuscitation for neurocritical care patients. Buffered crystalloids have been shown to reduce hyperchloremia in patients with subarachnoid hemorrhage without causing hyponatremia or hypo-osmolality. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000585DOI Listing
January 2019
1 Read

Cytomegalovirus infection in Systemic Lupus Erythematosus: report of four cases challenging the management of the disease, and literature review.

Lupus 2019 Jan 24:961203319825570. Epub 2019 Jan 24.

Rheumatology Unit, Azienda Ospedaliera San Camillo - Forlanini, Rome, Italy.

Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and laboratory characteristics. Our data suggest that lupus patients presenting with symptoms such as fever, diarrhea, and respiratory symptoms, alone or in combination, and laboratory evidence of leukopenia, elevated transaminases, and hyponatremia, especially in the setting of recent immunosuppressive treatments, should be screened for CMV. Read More

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http://dx.doi.org/10.1177/0961203319825570DOI Listing
January 2019
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Epidemiology of Exertional Heat Illnesses in National Collegiate Athletic Association Athletes During the 2009-2010 Through 2014-2015 Academic Years.

J Athl Train 2019 Jan 22. Epub 2019 Jan 22.

Department of Exercise and Sport Science, University of North Carolina at Chapel Hill.

Context: Exertional heat illnesses (EHIs) among football athletes have been widely researched, but data examining all collegiate sports are limited.

Objective: To describe the epidemiology of EHI in 25 National Collegiate Athletic Association (NCAA) sports.

Design: Descriptive epidemiology study. Read More

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http://dx.doi.org/10.4085/1062-6050-504-17DOI Listing
January 2019
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Hyponatremia at discharge is associated with adverse prognosis in acute heart failure syndromes with preserved ejection fraction: a report from the JASPER registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 22:2048872618822459. Epub 2019 Jan 22.

2 Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Japan.

Introduction:: Hyponatremia predicts adverse prognosis in patients with heart failure in particular with reduced ejection fraction. In contrast, it has recently been reported that hyponatremia on admission is not a predictor of post-discharge mortality in patients with heart failure with preserved ejection fraction. We investigated the prognostic impact of hyponatremia at discharge in patients with heart failure with preserved ejection fraction and its clinical characteristics. Read More

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http://dx.doi.org/10.1177/2048872618822459DOI Listing
January 2019
3 Reads

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Feb 18;20(2):282-296. Epub 2019 Jan 18.

Kindai University, Osaka-Sayama, Japan.

Background: Patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations have poor prognosis. We aimed to establish the efficacy of ramucirumab in patients with advanced hepatocellular carcinoma and α-fetoprotein concentrations of 400 ng/mL or higher.

Methods: REACH-2 was a randomised, double-blind, placebo-controlled, phase 3 trial done at 92 hospitals, clinics, and medical centres in 20 countries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183093
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http://dx.doi.org/10.1016/S1470-2045(18)30937-9DOI Listing
February 2019
12 Reads

Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan.

J Microbiol Immunol Infect 2019 Jan 8. Epub 2019 Jan 8.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan. Electronic address:

Background: Peritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure of PD, shift to hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.10.013DOI Listing
January 2019
1 Read

Hyponatraemia in patients with community acquired pneumonia; prevalence and etiology, and natural history of siad.

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Academic Departments of Endocrinology, Chemical Pathology, Beaumont Hospital, RCSI Medical School.

Objective: Hyponatraemia is common in community acquired pneumonia (CAP) and is associated with increased mortality. The mechanism of hyponatraemia in CAP is not completely understood and treatment is therefore ill-defined. We aimed to define the causation of hyponatraemia in CAP. Read More

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http://doi.wiley.com/10.1111/cen.13937
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http://dx.doi.org/10.1111/cen.13937DOI Listing
January 2019
4 Reads