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    37th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2016 Annual Meeting.
    Am J Med Genet A 2017 May 24. Epub 2017 May 24.
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
    The 37th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred on September 9th-14th, 2016 at the University of California-Los Angeles Conference Center in Lake Arrowhead, CA. The Workshop, which honors the legacy of David W. Read More

    Vitiligo: Not Simply a Skin Disease.
    Skinmed 2017 1;15(2):125-127. Epub 2017 Apr 1.
    Department of Dermatology, Robert Wood Johnson Medical School, Rutgers University, Somerset, NJ.
    Melanocytes, the cells responsible for skin pigmentation, are present in other parts of the body, such as the ocular, auditory, nervous, and cardiac systems. Within these systems, their roles serve a different purpose than their classical counterparts in skin as pigment cells. Such roles include cell turnover in retinal pigment epithelium, maintenance of balance and prevention of environmental damage in the auditory neuroepithelium, role-playing as dendritic cells within the leptomeninges, and prevention of oxidative damage in adipose tissue. Read More

    From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag.
    Ther Adv Hematol 2017 May 1;8(5):159-174. Epub 2017 Feb 1.
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.
    Thrombopoietin (TPO) is the most potent cytokine stimulating thrombopoiesis. Therapy with exogenous TPO is limited by the formation of antibodies cross-reacting with endogenous TPO. Mimetics of TPO are compounds with no antigenic similarity to TPO. Read More

    From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.
    Cell Calcium 2017 Apr 23. Epub 2017 Apr 23.
    Munich Center for Integrated Protein Science CIPSM, Center for Drug Research, Ludwig-Maximilians-Universität, München, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Germany. Electronic address:
    What do lysosomal storage disorders such as mucolipidosis type IV have in common with Ebola, cancer cell migration, or LDL-cholesterol trafficking? LDL-cholesterol, certain bacterial toxins and viruses, growth factors, receptors, integrins, macromolecules destined for degradation or secretion are all sorted and transported via the endolysosomal system (ES). There are several pathways known in the ES, e.g. Read More

    Impact of Vitiligo on Quality of Life.
    Actas Dermosifiliogr 2017 Apr 26. Epub 2017 Apr 26.
    Centro Dermatológico Dr. Ladislao de la Pascua, Secretaría de Salud de la Ciudad de México, Ciudad de México, México.
    Introduction And Objective: Vitiligo is a chronic autoimmune skin disease caused by the destruction of melanocytes. Although quality of life (QOL) in vitiligo has been studied in different countries, it has not yet been investigated in Mexico. The aim of this study was to assess the QOL of Mexican patients with vitiligo. Read More

    1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.
    Drug Discov Ther 2017 Apr 24. Epub 2017 Apr 24.
    PAK Research Center (Office).
    Artepillin C (ARC) and caffeic acid (CA) are among the major anti-cancer ingredients of propolis, and block the oncogenic/melanogenic/ageing kinase PAK1. However, mainly due to their COOH moiety, cell-permeability of these herbal compounds is rather limited. Thus, in this study, in an attempt to increase their cell-permeability without any significant loss of their water-solubility, we have esterized both ARC and CA with the water-soluble 1,2,3-triazolyl alcohol through Click Chemistry. Read More

    Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study.
    Lasers Med Sci 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, or laser toning, has yielded favorable outcomes in various benign pigmented disorders. However, the exact mechanism of action of laser toning has not been fully elucidated. We sought to determine the inhibitory effect of laser toning on melanogenesis and to assess how laser passes influence the outcomes. Read More

    Unilateral Pigmented Paravenous Retinochoroidal Atrophy Associated With Presumed Ocular Tuberculosis.
    Ophthalmic Surg Lasers Imaging Retina 2017 Apr;48(4):345-349
    This report describes a case of unilateral pigmented paravenous retinochoroidal atrophy (PPRCA) in a patient with low-grade unilateral intermediate uveitis. A 31-year-old woman, previously diagnosed with intermediate uveitis in the right eye (OD) presented to the clinic. Best-corrected visual acuity was 20/20 OD. Read More

    Focal Scalp Hair Heterochromia in an Infant.
    Sultan Qaboos Univ Med J 2017 Feb 30;17(1):e116-e118. Epub 2017 Mar 30.
    Department of Dermatology, Saham Hospital, Saham, Oman.
    Hair heterochromia involves the presence of two different non-artificially induced colours of hair in the same individual which can be due to either iron deficiency anaemia, genetic mutations or mosaicism. We report a six-month old male infant who presented to the Department of Dermatology, Saham Hospital, Saham, Oman, in 2013 with focal scalp hair heterochromia without any detectable underlying abnormalities. The area of heterochromia was still noticeable at a one-year follow-up. Read More

    Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report.
    Medicine (Baltimore) 2017 Apr;96(15):e6470
    aDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University bDepartment of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
    Rationale: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.

    Patient Concerns: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. Read More

    Surgical suturing-induced melanocytic nevi. A new type of eruptive melanocytic nevi?
    J Dermatol Case Rep 2016 Nov 30;10(3):49-52. Epub 2016 Nov 30.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" University General Hospital, 1 Rimini str, 12462, Chaidari, Athens, Greece.
    Background: Nevogenesis is a complex process involving several pathogenetic mechanisms, including genetic factors, hormonal influences and UV-radiation. Trauma has been described as a triggering factor for an alternative pathway of nevogenesis. Eruptive melanocytic nevi (EMN), related either to immunosuppression or to blistering disorders, represent a special type of nevi probably induced by the disruption of the dermo-epidermal junction and consequent proliferation of quiescent pigment cells during re-epithelization. Read More

    UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes.
    J Invest Dermatol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Dermatology, Seoul National University College of Medicine; Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University; Deparment of Biomedical Science, Seoul National University Graduate School, Seoul, Republic of Korea. Electronic address:
    Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is involved in many signaling pathways via the ubiquitin-proteasome system. UCHL1 is expressed in the human skin and serves as a neuronal marker; however, its functions in melanogenesis remain unknown. Here, we investigated the role of UCHL1 in melanogenesis, and elucidated the underlying mechanism using human melanocytes. Read More

    Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.
    J Clin Diagn Res 2017 Feb 1;11(2):FD01-FD02. Epub 2017 Feb 1.
    Post Graduate Trainee, Department of Pharmacology, Institute of Post Graduate Medical Education and Research , Kolkata, West Bengal, India .
    Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire antibiotic resistance. Read More

    Genetic and Histopathologic Inter-Tumor Heterogeneity in Primary Aldosteronism.
    J Clin Endocrinol Metab 2017 Mar 24. Epub 2017 Mar 24.
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, RFB 287, 02115 Boston, MA, USA.
    Context: Whether primary aldosteronism (PA) is the consequence of a monoclonal or multiclonal process is unclear.

    Case Description: A 48-year-old man with severe bilateral PA refractory to medical therapy underwent unilateral adrenalectomy of the dominant adrenal. Although computed tomography (CT) showed three left-sided cortical nodules, post-surgical histopathology and genetic analysis revealed five different adrenocortical adenomas. Read More

    The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
    Int J Mol Med 2017 Feb 9. Epub 2017 Feb 9.
    Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan, R.O.C.
    Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. Read More

    Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle.
    Stem Cells Int 2017 27;2017:2857478. Epub 2017 Feb 27.
    Department of Cell Biology, Third Military Medical University, Chongqing 400038, China; Chongqing Stem Cell Therapy Engineering Technical Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
    Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-related protein 4 (sFRP4) is preferentially expressed in the skin epidermal cells rather than in melanocytes. Read More

    Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
    Molecules 2017 Mar 23;22(4). Epub 2017 Mar 23.
    Division of Pharmacognosy and Natural Product Chemistry, Department of Pharmacy, National & Kapodistrian University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece.
    In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts from Greek plants for potential tyrosinase inhibitive properties. Read More

    Cutaneous Mastocytosis With Atypical Mast Cells in a 7-Year-Old Girl.
    Am J Dermatopathol 2017 Apr;39(4):310-312
    *Department of Dermatology, Complejo Hospitalario Universitario Insular Materno-Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain;†Department of Pathology and Dermatology, Wake Forest Baptist Health, Winston-Salem, NC; and‡Department of Pathology, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain.
    Cutaneous mastocytosis is defined by the presence of mast cells within the skin in the absence of other criteria for the diagnosis of systemic mastocytosis. Mast cells are characterized by an abundant granular cytoplasm and a round to oval or spindle-shaped nuclei. The presence of mast cells with bilobed and multilobed nuclei in cutaneous mastocytosis is a rare phenomenon and has been rarely reported in the literature. Read More

    Depigmentation Therapies for Vitiligo.
    Dermatol Clin 2017 Apr;35(2):219-227
    Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard #650, Los Angeles, CA 90036, USA.
    The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal skin may be a better choice. Candidates for depigmentation therapy should be carefully screened and patient education is essential. Read More

    Anti-cryptococcal activity of ethanol crude extract and hexane fraction from Ocimum basilicum var. Maria bonita: mechanisms of action and synergism with amphotericin B and Ocimum basilicum essential oil.
    Pharm Biol 2017 Dec;55(1):1380-1388
    a Department of General Microbiology , Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
    Context: Ocimum basilicum L. (Lamiaceae) has been used in folk medicine to treat headaches, kidney disorders, and intestinal worms.

    Objective: This study evaluates the anti-cryptococcal activity of ethanol crude extract and hexane fraction obtained from O. Read More

    Identification of two novel mutations in the SLC45A2 gene in a Hungarian pedigree affected by unusual OCA type 4.
    BMC Med Genet 2017 Mar 15;18(1):27. Epub 2017 Mar 15.
    Department of Medical Genetics, University of Szeged, 6 Somogyi Bela Street, 6720, Szeged, Hungary.
    Background: Oculocutaneous albinism (OCA) is a clinically and genetically heterogenic group of pigmentation abnormalities. OCA type IV (OCA4, OMIM 606574) develops due to homozygous or compound heterozygous mutations in the solute carrier family 45, member 2 (SLC45A2) gene. This gene encodes a membrane-associated transport protein, which regulates tyrosinase activity and, thus, melanin content by changing melanosomal pH and disrupting the incorporation of copper into tyrosinase. Read More

    [Piebaldism: a pigmentary anomaly to recognize: about a case and review of the literature].
    Pan Afr Med J 2016 14;25:155. Epub 2016 Nov 14.
    Service des Urgences Médicales Pédiatriques, Hôpital d'Enfants Rabat, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    Piebaldism is a rare autosomal dominant disorder characterized by an abnormal congenital skin pigmentation causing hypopigmented areas. It is due to an abnormal melanocytes development. It usually affects only the skin, but it may be associated with other anomalies or confused with other differential diagnoses. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity.
    J Am Acad Dermatol 2017 May 1;76(5):847-855.e5. Epub 2017 Mar 1.
    Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:
    Background: Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies.

    Objective: To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and healthy subjects.

    Methods: Patient skin was sampled via a modified suction-blister technique, allowing for minimally invasive, objective assessment of cytokines and T-cell infiltrates in the interstitial skin fluid. Read More

    Clinical markers of vitiligo activity.
    J Am Acad Dermatol 2017 May 27;76(5):856-862. Epub 2017 Feb 27.
    Pigmentary Disorders Outpatient Clinic, Hospital Saint-André, Bordeaux, France.
    Background: Current modalities of understanding disease state (active/stable) are limited when considering treatment of vitiligo.

    Objective: We sought to develop a rapid, accurate, and noninvasive assessment of vitiligo state.

    Methods: In daylight and Wood's light examinations, 2 common clinical types of vitiligo were identified as amelanotic with sharply demarcated borders and hypomelanotic with poorly defined borders. Read More

    Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea.
    J Am Acad Dermatol 2017 May 24;76(5):871-878. Epub 2017 Feb 24.
    Department of Dermatology, College of Medicine, Nowon Eulji Medical Center, Eulji University, Seoul, Korea. Electronic address:
    Background: Associations between vitiligo and thyroid diseases have been reported repeatedly.

    Objective: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database.

    Methods: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. Read More

    DETAILED RETINAL IMAGING IN CARRIERS OF OCULAR ALBINISM.
    Retina 2017 Feb 23. Epub 2017 Feb 23.
    *University College London Institute of Ophthalmology, University College London, London, United Kingdom; †Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom; ‡Section of Ophthalmology & Neuroscience, Leeds Institute of Biomedical & Clinical Sciences, St James' University Hospital, Leeds, United Kingdom; §NIHR BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom; ¶Department of Haematology, University of Cambridge, NHS Blood and Transplant Centre, Cambridge, United Kingdom; **Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; and ††Department of Ophthalmology, University of California San Francisco Medical School, San Francisco, California.
    Background: Albinism refers to a group of disorders primarily characterized by hypopigmentation. Affected individuals usually manifest both ocular and cutaneous features of the disease, but occasionally hair and skin pigmentation may appear normal. This is the case in ocular albinism, an X chromosome linked disorder resulting from mutation of GPR143. Read More

    A novel mutation in the STK11 gene causes heritable Peutz-Jeghers syndrome - a case report.
    BMC Med Genet 2017 Feb 23;18(1):19. Epub 2017 Feb 23.
    Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74 Zhongshan 2 Road, Guangzhou, 510080, China.
    Background: Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. STK11 has been identified as a causative gene for this disease.

    Case Presentation: Herein we report a Chinese Han kindred with PJS. Read More

    Disruption of the Photoreceptor Inner Segment-Outer Segment Junction in a 6-Year-Old Girl with Joubert Syndrome.
    Neuroophthalmology 2017 Feb 19;41(1):19-23. Epub 2016 Oct 19.
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP) , Kodaira, Tokyo, Japan.
    Joubert syndrome (JS) is a spectrum of genetic disorders characterised by cerebellar and brainstem malformation called "molar tooth sign", resulting in hypotonia, developmental delay, and intellectual disability. Here we describe a young female JS patient with "salt-and-pepper" fundus and inner segment-outer segment junction (IS/OS line) discontinuity, with a lack of external limiting membrane. Ocular coherence tomography (OCT) detected blurred external retinal layers in the macula centre. Read More

    Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo.
    Skin Pharmacol Physiol 2017 22;30(1):42-45. Epub 2017 Feb 22.
    Department of Surgery/Dermatology, Carol Davila University, Bucharest, Romania.
    Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Read More

    Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study.
    J Am Acad Dermatol 2017 May 16;76(5):841-846.e2. Epub 2017 Feb 16.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders.

    Objective: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. Read More

    The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo.
    J Am Acad Dermatol 2017 May 16;76(5):879-888. Epub 2017 Feb 16.
    Department of Dermatology, Cairo University, Kasr Al Aini Hospital, Cairo, Egypt.
    Background: Treatment of vitiligo with narrowband ultraviolet B light (NBUVB) is an important component of the current standard of care. However, there are no consistent guidelines regarding the dosing and administration of NBUVB in vitiligo, reflected by varied treatment practices around the world.

    Objective: To create phototherapy recommendations to facilitate clinical management and identify areas requiring future research. Read More

    Reduced immunohistochemical expression of adhesion molecules in vitiligo skin biopsies.
    Pathol Res Pract 2017 Mar 30;213(3):199-204. Epub 2016 Dec 30.
    Experimental Pathology Laboratory, School of Medicine, Pontifical Catholic University of Paraná, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, CEP 80215-901, Brazil.
    Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epidermis of vitiligo and non lesional vitiligo skin. Sixty-six specimens of lesional and non lesional skin from 33 volunteers with vitiligo were evaluated by immunohistochemistry using anti-beta-catenin, anti-E-cadherin, anti-laminin, anti-beta1 integrin, anti-collagen IV, anti-ICAM-1 and anti-VCAM-1 antibodies. Biopsies of vitiligo skin demonstrated a significant reduction in the expression of laminin and integrin. Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    Influence of Pregnancy on Vitiligo Activity.
    J Clin Aesthet Dermatol 2016 Dec 1;9(12):21-25. Epub 2016 Dec 1.
    Department of Dermatology, Loyola University, Stritch School of Medicine, Maywood, Illinois.
    Background: Vitiligo vulgaris, an acquired disease related to autoimmune activity directed against melanocytes, is a common disorder of pigmentation affecting up to one percent of the population. Several autoimmune disorders are reported to improve during pregnancy-a state of relative immunosuppression. Objectives: To assess self-reported changes in vitiligo disease activity that occurred during pregnancy. Read More

    The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
    Int J Mol Med 2017 Mar 9;39(3):595-602. Epub 2017 Feb 9.
    Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan, R.O.C.
    Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Translucent Appearance of Middle Cerebral Artery Bifurcation Aneurysms Is Risk Factor for Intraoperative Aneurysm Rupture During Clipping.
    World Neurosurg 2017 May 9;101:149-154. Epub 2017 Feb 9.
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases, Beijing, P. R. China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P. R. China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, P. R. China. Electronic address:
    Introduction: The rupture rate of unruptured intracranial aneurysms is influenced by certain angioarchitectural and hemodynamic characteristics. Recently the translucent appearance of aneurysms was described as a possible risk factor for aneurysm rupture. In this study, we investigate the intraoperative rupture risk of surgically clipped unruptured translucent aneurysms (TAs). Read More

    The synergistic effect of maltose enhances the anti-melanogenic activity of acarbose.
    Arch Dermatol Res 2017 Apr 9;309(3):217-223. Epub 2017 Feb 9.
    AmorePacific Corporation R&D Center, Yongin, Gyeonggi-do, 446-729, South Korea.
    Melanocytes play an important role in maintaining epidermal homeostasis by producing melanin and protecting the skin from harmful environmental factors. However, excessive up- or down-regulation of melanin production often causes hyper- or hypo-pigmented disorders, respectively, which affect the patient's quality of life. Therefore, various strategies for modulating melanin levels have been developed by the pharmaceutical and cosmetic industries. Read More

    Assessment of skin pigmentation by confocal microscopy: Influence of solar exposure and protection habits on cutaneous hyperchromias.
    J Cosmet Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Background: Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in the different types of hyperpigmentations need better elucidation.

    Objective: To assess the influence of solar exposure and protection habits on the pattern of skin pigmentation using reflectance confocal microscopy (RCM). Read More

    Effect of Procedural-Related Variables on Melanocyte-Keratinocyte Suspension Transplantation in Nonsegmental Stable Vitiligo: A Clinical and Immunocytochemical Study.
    Dermatol Surg 2017 Feb;43(2):226-235
    Departments of *Dermatology, †Histology, and ‡Clinical Pathology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cario, Egypt.
    Background: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables.

    Objective: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. Read More

    Ultrathin Skin Grafting in Resistant Stable Vitiligo: A Follow-up Study of 8 Years in 370 Patients.
    Dermatol Surg 2017 Feb;43(2):218-225
    *All authors are affiliated with the CUTIS Institute of Dermatology, Srinagar, India.
    Background: Ultrathin skin grafting (UTSG) is a tissue grafting technique used in resistant stable vitiligo.

    Objective: To assess long-term follow-up results achieved with UTSG in vitiligo.

    Methods: Over a span of 8 years, a total of 415 patients with stable vitiligo were treated with UTSG at the authors' institute. Read More

    Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.
    Am J Hum Genet 2017 Feb;100(2):364-370
    St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, UK; Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee DD1 5EH, UK. Electronic address:
    SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in an Arab-Israeli pedigree mapped the gene to an approximately 25 cM locus on chromosome 1q24-q32. By using whole-exome sequencing in a further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members. Read More

    JAK inhibitors in dermatology: The promise of a new drug class.
    J Am Acad Dermatol 2017 Apr 28;76(4):736-744. Epub 2017 Jan 28.
    Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. Electronic address:
    New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven by soluble inflammatory mediators, which rely on JAK-STAT signaling, and inhibition of this pathway using JAK inhibitors might be a useful therapeutic strategy for these diseases. Read More

    Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression.
    J Invest Dermatol 2017 May 26;137(5):1126-1134. Epub 2017 Jan 26.
    Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:
    Generalized nonsegmental vitiligo is often associated with the activation of melanocyte-specific autoimmunity. Because chemokines play an important role in the maintenance of immune responses, we examined chemotactic signatures in cultured vitiligo melanocytes and skin samples of early (≤2 months) and advanced (≥6 months) vitiligo. Analysis showed that melanocytes in early lesions have altered expression of several chemotaxis-associated molecules, including elevated secretion of CXCL12 and CCL5. Read More

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