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    Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis.
    Oecologia 2017 Jul 20. Epub 2017 Jul 20.
    Icelandic Institute of Natural History, Garðabær, Iceland.
    Melanins form the basis of animal pigmentation. When the sulphurated form of melanin, termed pheomelanin, is synthesized, the sulfhydryl group of cysteine is incorporated to the pigment structure. This may constrain physiological performance because it consumes the most important intracellular antioxidant (i. Read More

    Melasma: an Up-to-Date Comprehensive Review.
    Dermatol Ther (Heidelb) 2017 Jul 19. Epub 2017 Jul 19.
    Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
    Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Read More

    Precise role of dermal fibroblasts on melanocyte pigmentation.
    J Dermatol Sci 2017 Jul 1. Epub 2017 Jul 1.
    Engineering and Cutaneous Biology Laboratory, UMR 1098, University of Bourgogne Franche-Comté, Besançon, France; Department of Dermatology, University Hospital, Besançon, France.
    Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes. Read More

    Organ-sparing surgery for large cell calcifying Sertoli cell tumour in a patient with Carney complex.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
    Carney complex is a rare genetic disease characterised by a complex of myxomas, spotty pigmentation and endocrine overactivity. At diagnosis, about one-third of male patients presents with testicular tumours, namely large cell calcifying Sertoli cell tumours, which are often multicentric and/or bilateral and have a low malignant potential. Although radical orchiectomy is the gold standard for the treatment of testicular neoplasms, a conservative approach with partial orchiectomy or tumourectomy may be the best treatment option for these patients, allowing the preservation of endocrine function, fertility and body image. Read More

    Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin.
    J Photochem Photobiol B 2017 Jun 29;173:551-559. Epub 2017 Jun 29.
    Department of Health Care & Science, Jeonju University, Jeonju 55069, Republic of Korea; Research Institute, Ato Q&A Corporation, Jeonju 55069, Republic of Korea. Electronic address:
    Humans have become exposed to another form of a trait which is ultraviolet B (UVB) radiation reaching the earth's surface. This has become a major source of oxidative stress that ultimately leads to inflammation, DNA damage, photoaging and pigmentation disorders etc. Although several studies have shown the photo-protective role of different grape parts like the fruits and seeds, little or no data demonstrating the in vivo photo-protective role of grape stem, which is the most discarded part of the grape are available. Read More

    Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells.
    Arch Pharm Res 2017 Jul 10. Epub 2017 Jul 10.
    College of Pharmacy, Chungbuk National University, 1 Chungdae, Seowon, Cheongju, Chungbuk, 28644, South Korea.
    Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz. Read More

    Adrenal crisis in metastatic breast cancer.
    BMJ Case Rep 2017 Jul 6;2017. Epub 2017 Jul 6.
    Interne I: Internistische Onkologie, Hämatologie u. Gastroenterologie, Ordensklinikum Linz Krankenhaus d. Barmherzigen Schwestern Linz Betriebs GmbH, Linz, Austria.
    A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment. Read More

    Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution.
    J Cosmet Dermatol 2017 Jul 3. Epub 2017 Jul 3.
    Arterra Bioscience srl, Napoli, Italy.
    Background: Skin whitening products, used for ages by Asian people for cultural and esthetic purposes, are very popular nowadays in Western countries as well, where the need to inhibit skin spots after sun exposure has become not only a cosmetic but also a health-related issue. Thus, the development of effective and safe depigmenting agents derived from natural products gets continuous attention by cosmetic brands and consumers.

    Objectives: The aim of this study was to determine the effects of two preparations, obtained from the hairy root cultures of the species Brassica rapa, on melanogenesis and the expression of the extracellular matrix proteins involved in a correct pigment distribution. Read More

    Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
    Angew Chem Int Ed Engl 2017 Jun 29. Epub 2017 Jun 29.
    Laboratory of Biophysical Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
    Tyrosinase-related protein 1 (TYRP1) is one of three tyrosinase-like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair. Difficulties with producing these enzymes in pure form have hampered the understanding of their activity and the effect of mutations that cause albinism and pigmentation disorders. Herein we show that the typical tyrosinase-like subdomain of TYRP1 contains two zinc ions in the active site instead of copper ions as found in tyrosinases, which explains why TYRP1 does not exhibit tyrosinase redox activity. Read More

    Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efficacy and Healthcare Resource Utilization for Seven Key Indications.
    Adv Ther 2017 Jun 28. Epub 2017 Jun 28.
    Mallinckrodt Pharmaceuticals Inc., Hampton, NJ, USA.
    Introduction: Repository corticotropin injection (RCI; H.P. Acthar(®) Gel; Mallinckrodt Pharmaceuticals Inc. Read More

    Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
    Arch Endocrinol Metab 2017 Jun 26. Epub 2017 Jun 26.
    Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
    Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Read More

    Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.
    Tumour Biol 2017 Jun;39(6):1010428317705131
    1 Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China.
    Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. Read More

    Clinical evaluation of the efficacy and safety of combined bipolar radiofrequency and optical energies vs. optical energy alone for the treatment of aging hands.
    Lasers Med Sci 2017 Jun 23. Epub 2017 Jun 23.
    Verner Clinic Tel Aviv, 39 Jerusalem St., POB 39, 55423, Kiriat Ono, Israel.
    Different treatment modalities are used for the treatment and esthetic improvement of aging hands. This study evaluated the efficacy and safety of a novel technology, which combines bipolar radio frequency (RF) and optical energies for the cosmetic treatment of aging hands. The objective of the study was to assess the efficacy, safety, tolerability, and patient satisfaction of combined bipolar radiofrequency and optical energies vs. Read More

    A reporter mouse model for in vivo tracing and in vitro molecular studies of melanocytic lineage cells and their diseases.
    Biol Open 2017 Jun 22. Epub 2017 Jun 22.
    Dept. of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Alterations in melanocytic lineage cells give rise to a plethora of distinct human diseases, including neurocristopathies, cutaneous pigmentation disorders, loss of vision and hearing, as well as melanoma. Understanding the ontogeny and biology of melanocytic cells, as well as how they interact with their surrounding environment, are key steps in the development of therapies for diseases that involve this cell lineage. Efforts to culture and characterize primary melanocytes from normal or genetically engineered mouse models have at times yielded contrasting observations. Read More

    Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism.
    Invest Ophthalmol Vis Sci 2017 Jun;58(7):3118-3126
    Pharmaceutical Chemistry I, PharmaCenter Bonn, University of Bonn, Bonn, Germany.
    Purpose: GPR143 regulates melanosome biogenesis and organelle size in pigment cells. The mechanisms underlying receptor function remain unclear. G protein-coupled receptors (GPCRs) are excellent pharmacologic targets; thus, we developed and applied a screening approach to identify potential GPR143 ligands and chemical modulators. Read More

    Isolation and Characterization of Isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo.
    Evid Based Complement Alternat Med 2017 24;2017:1401279. Epub 2017 May 24.
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
    Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. Read More

    Current and emerging treatments for vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):17-29
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Read More

    New discoveries in the pathogenesis and classification of vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):1-13
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Read More

    Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.
    Bioorg Med Chem Lett 2017 Aug 3;27(15):3374-3377. Epub 2017 Jun 3.
    College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address:
    We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. Read More

    [Overlap syndrome. LEOPARD and neurofibromatosis. A case report].
    Rev Med Inst Mex Seguro Soc 2017 Jul-Aug;55(4):540-543
    Servicio de Terapia Intensiva, Hospital General de Zona 30 "Iztacalco", Instituto Mexicano del Seguro Social, Ciudad de México, México.
    We expose a clinical case of a 43-year-old patient who was attended at the Dermatology service in a general hospital of the Instituto Mexicano del Seguro Social, with a disseminated pattern of lentigines, psychomotor retardation and electrocardiographic abnormalities. Afterwards, we made an analysis of the literature. Read More

    Pigmentation - more than one master?
    Pigment Cell Melanoma Res 2017 Jun 5. Epub 2017 Jun 5.
    Vertebrate pigmentation is a process directed by various transcriptional regulators, that drive the specification of melanoblasts from neural crest cells, their proliferation and migration, and terminal differentiation into melanocytes, culminating in the generation of pigment and it's distribution to surrounding keratinocytes. The transcription factor MITF has been coined the "master regulator" of melanocyte development (reviewed in (Steingrímsson, Copeland and Jenkins, 2004)), as it drives both the specification and differentiation of melanocytes. It is associated with pigmentation disorders in human, and Mitf mutant mice have a varying degree of pigmentation defects. Read More

    Dermoscopy in the Evaluation of Nail Disorders.
    Skin Appendage Disord 2017 May 8;3(2):70-82. Epub 2017 Mar 8.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. Read More

    Acetazolamide inhibits the level of tyrosinase and melanin: An enzyme kinetic, in vitro, in vivo and in silico studies.
    Chem Biodivers 2017 May 29. Epub 2017 May 29.
    Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro 56, Gongju, Chungnam, 32588, Republic of Korea.
    Melanin is the major factor that determines skin color and protects from ultraviolet radiation. In present study we evaluated the anti-melanogenesis effect of acetazolamide (ACZ) using four different approaches: enzyme kinetic, in vitro, in vivo and in silico. ACZ demonstrated significant inhibitory activity (IC50 7. Read More

    Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study.
    Br J Dermatol 2017 May 27. Epub 2017 May 27.
    Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
    Herein we describe the usefulness of a successful combination of dermoscopy and in vivo RCM for the early diagnosis of 3 AM in 2 OCA patients OCA is a group of rare autosomal recessive disorders of pigmentation. It consists in the absence or reduction of melanin in the skin, hair, and eyes due to a partial or total deficit in the activity of tyrosinase(TYR)(1) or other related genes(2,3) . Those patients are at higher risk of non melanoma skin cancer, while still debated is their increased risk of melanoma, in particular amelanotic(4) . Read More

    37th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2016 Annual Meeting.
    Am J Med Genet A 2017 May 24:2007-2073. Epub 2017 May 24.
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
    The 37th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred on September 9th-14th, 2016 at the University of California-Los Angeles Conference Center in Lake Arrowhead, CA. The Workshop, which honors the legacy of David W. Read More

    Vitiligo: Not Simply a Skin Disease.
    Skinmed 2017 1;15(2):125-127. Epub 2017 Apr 1.
    Department of Dermatology, Robert Wood Johnson Medical School, Rutgers University, Somerset, NJ.
    Melanocytes, the cells responsible for skin pigmentation, are present in other parts of the body, such as the ocular, auditory, nervous, and cardiac systems. Within these systems, their roles serve a different purpose than their classical counterparts in skin as pigment cells. Such roles include cell turnover in retinal pigment epithelium, maintenance of balance and prevention of environmental damage in the auditory neuroepithelium, role-playing as dendritic cells within the leptomeninges, and prevention of oxidative damage in adipose tissue. Read More

    Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study.
    Medicine (Baltimore) 2017 May;96(19):e6897
    aDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing bSuzhou NanoMED skincare Inc, Suzhou, China.
    To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0. Read More

    Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11.
    Int J Pediatr Otorhinolaryngol 2017 Jun 17;97:228-234. Epub 2017 Apr 17.
    Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
    Existing literature only reports a few patients with Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) who underwent cochlear implantation (CI). The present study describes four NS patients and one NSML patient with a PTPN11 mutation. They all had severe to profound hearing loss, and they received a CI. Read More

    From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag.
    Ther Adv Hematol 2017 May 1;8(5):159-174. Epub 2017 Feb 1.
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.
    Thrombopoietin (TPO) is the most potent cytokine stimulating thrombopoiesis. Therapy with exogenous TPO is limited by the formation of antibodies cross-reacting with endogenous TPO. Mimetics of TPO are compounds with no antigenic similarity to TPO. Read More

    From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.
    Cell Calcium 2017 Apr 23. Epub 2017 Apr 23.
    Munich Center for Integrated Protein Science CIPSM, Center for Drug Research, Ludwig-Maximilians-Universität, München, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Germany. Electronic address:
    What do lysosomal storage disorders such as mucolipidosis type IV have in common with Ebola, cancer cell migration, or LDL-cholesterol trafficking? LDL-cholesterol, certain bacterial toxins and viruses, growth factors, receptors, integrins, macromolecules destined for degradation or secretion are all sorted and transported via the endolysosomal system (ES). There are several pathways known in the ES, e.g. Read More

    Impact of Vitiligo on Quality of Life.
    Actas Dermosifiliogr 2017 Apr 26. Epub 2017 Apr 26.
    Centro Dermatológico Dr. Ladislao de la Pascua, Secretaría de Salud de la Ciudad de México, Ciudad de México, México.
    Introduction And Objective: Vitiligo is a chronic autoimmune skin disease caused by the destruction of melanocytes. Although quality of life (QOL) in vitiligo has been studied in different countries, it has not yet been investigated in Mexico. The aim of this study was to assess the QOL of Mexican patients with vitiligo. Read More

    Cases of primary malignant melanoma and melanocytosis of the esophagus observed by magnifying endoscopy: Application to differential diagnosis: case series.
    Medicine (Baltimore) 2017 Apr;96(17):e6701
    aDepartment of Medical Oncology bDepartment of Hematology, Sapporo Medical University School of Medicine, Sapporo cDepartment of Gastroenterology and Oncology, University of Tokushima, Tokushima, Japan.
    Rationale: Primary malignant melanoma of the esophagus (PMME) is a rare disease with an extremely poor prognosis. In contrast, melanocytosis is a benign condition defined as melanocytic proliferation with melanin deposition. PMME is often accompanied by melanocytosis, but differentiating between them is difficult because of their similar appearance. Read More

    Peutz-Jeghers syndrome with intermittent upper intestinal obstruction: A case report and review of the literature.
    Medicine (Baltimore) 2017 Apr;96(17):e6538
    aDepartment of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China bDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic syndrome characterized by a unique type of gastrointestinal hamartomatous polyp associated with oral and anal mucocutaneous pigmentations. Peutz-Jeghers polyps occur most numerously in the small intestine but frequently in the colon and stomach, only a few cases have been reported in the duodenum.

    Patient Concern: A further family history survey discovered 10 out of 14 members of the family (in 4 generations) had mucocutaneous pigmentations, but many of them were living in rural areas where they had no access to specialized medical services, so none were checked with endoscopy for polyps of hamartoma. Read More

    1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.
    Drug Discov Ther 2017 May 24;11(2):104-109. Epub 2017 Apr 24.
    PAK Research Center (Office).
    Artepillin C (ARC) and caffeic acid (CA) are among the major anti-cancer ingredients of propolis, and block the oncogenic/melanogenic/ageing kinase PAK1. However, mainly due to their COOH moiety, cell-permeability of these herbal compounds is rather limited. Thus, in this study, in an attempt to increase their cell-permeability without any significant loss of their water-solubility, we have esterized both ARC and CA with the water-soluble 1,2,3-triazolyl alcohol through Click Chemistry. Read More

    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Jul;43(7):911-919
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study.
    Lasers Med Sci 2017 Jul 20;32(5):1063-1069. Epub 2017 Apr 20.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, or laser toning, has yielded favorable outcomes in various benign pigmented disorders. However, the exact mechanism of action of laser toning has not been fully elucidated. We sought to determine the inhibitory effect of laser toning on melanogenesis and to assess how laser passes influence the outcomes. Read More

    Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum.
    Intern Med 2017 15;56(8):979-982. Epub 2017 Apr 15.
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
    Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly intrastrand DNA cross-links, and sensitivity to CDDP depends on the DNA repair system. Several in vitro studies have suggested that treatment with CDDP may cause enhanced adverse events as well as anti-tumor activity in cancer patients with XP. Read More

    Unilateral Pigmented Paravenous Retinochoroidal Atrophy Associated With Presumed Ocular Tuberculosis.
    Ophthalmic Surg Lasers Imaging Retina 2017 Apr;48(4):345-349
    This report describes a case of unilateral pigmented paravenous retinochoroidal atrophy (PPRCA) in a patient with low-grade unilateral intermediate uveitis. A 31-year-old woman, previously diagnosed with intermediate uveitis in the right eye (OD) presented to the clinic. Best-corrected visual acuity was 20/20 OD. Read More

    Focal Scalp Hair Heterochromia in an Infant.
    Sultan Qaboos Univ Med J 2017 Feb 30;17(1):e116-e118. Epub 2017 Mar 30.
    Department of Dermatology, Saham Hospital, Saham, Oman.
    Hair heterochromia involves the presence of two different non-artificially induced colours of hair in the same individual which can be due to either iron deficiency anaemia, genetic mutations or mosaicism. We report a six-month old male infant who presented to the Department of Dermatology, Saham Hospital, Saham, Oman, in 2013 with focal scalp hair heterochromia without any detectable underlying abnormalities. The area of heterochromia was still noticeable at a one-year follow-up. Read More

    [Pigmentations of the oral cavity].
    Presse Med 2017 Mar 12;46(3):303-319. Epub 2017 Apr 12.
    Institut universitaire du cancer, Toulouse Oncopole 1, oncodermatologie et consultation pluridisciplinaire de pathologies buccales, avenue Irène-Joliot-Curie, 31100 Toulouse, France.
    Buccal mucosa color is explained by hemoglobin in the vessels and melanin in the epithelium. Abnormal presence of melanin pigments (hypermelaninosis, hypermelanocytosis), hematic pigments (hemoglobin, hemosiderin, iron) but also some exogenous circonstancies explain pigmented lesions (figure 1). These lesions could be localized (single lesions), multifocal (multiple lesions) or diffused. Read More

    Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report.
    Medicine (Baltimore) 2017 Apr;96(15):e6470
    aDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University bDepartment of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
    Rationale: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.

    Patient Concerns: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. Read More

    Surgical suturing-induced melanocytic nevi. A new type of eruptive melanocytic nevi?
    J Dermatol Case Rep 2016 Nov 30;10(3):49-52. Epub 2016 Nov 30.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" University General Hospital, 1 Rimini str, 12462, Chaidari, Athens, Greece.
    Background: Nevogenesis is a complex process involving several pathogenetic mechanisms, including genetic factors, hormonal influences and UV-radiation. Trauma has been described as a triggering factor for an alternative pathway of nevogenesis. Eruptive melanocytic nevi (EMN), related either to immunosuppression or to blistering disorders, represent a special type of nevi probably induced by the disruption of the dermo-epidermal junction and consequent proliferation of quiescent pigment cells during re-epithelization. Read More

    Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice.
    Biochem Biophys Res Commun 2017 May 7;487(1):62-67. Epub 2017 Apr 7.
    Department of Zoology, Savitribai Phule Pune University, Pune 411007, India. Electronic address:
    Geraniin is a hydrolysable tannin, widely present in many plant species, specifically used in traditional medicines. It has been shown to exhibit strong antioxidant activity in vitro. This study was performed to investigate hepatoprotective activity of geraniin against carbon tetrachloride (CCl4) induced damage in Swiss albino mice. Read More

    UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes.
    J Invest Dermatol 2017 Aug 6;137(8):1757-1765. Epub 2017 Apr 6.
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Deparment of Biomedical Science, Seoul National University Graduate School, Seoul, Republic of Korea. Electronic address:
    Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is involved in many signaling pathways via the ubiquitin-proteasome system. UCHL1 is expressed in the human skin and serves as a neuronal marker; however, its functions in melanogenesis remain unknown. Here, we investigated the role of UCHL1 in melanogenesis and elucidated the underlying mechanism using human melanocytes. Read More

    Pigmented and albino rats differ in their responses to moderate, acute and reversible intraocular pressure elevation.
    Doc Ophthalmol 2017 Jun 7;134(3):205-219. Epub 2017 Apr 7.
    School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
    Purpose: To compare the electrophysiological and morphological responses to acute, moderately elevated intraocular pressure (IOP) in Sprague-Dawley (SD), Long-Evans (LE) and Brown Norway (BN) rat eyes.

    Methods: Eleven-week-old SD (n = 5), LE (n = 5) and BN (n = 5) rats were used. Scotopic threshold responses (STRs), Maxwellian flash electroretinograms (ERGs) or ultrahigh-resolution optical coherence tomography (UHR-OCT) images of the rat retinas were collected from both eyes before, during and after IOP elevation of one eye. Read More

    Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.
    J Clin Diagn Res 2017 Feb 1;11(2):FD01-FD02. Epub 2017 Feb 1.
    Post Graduate Trainee, Department of Pharmacology, Institute of Post Graduate Medical Education and Research , Kolkata, West Bengal, India .
    Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire antibiotic resistance. Read More

    Dermatologic Features of Classic Movie Villains: The Face of Evil.
    JAMA Dermatol 2017 Jun;153(6):559-564
    Department of Dermatology, The University of Texas Medical Branch, Galveston.
    Importance: Dichotomous dermatologic depictions of heroes and villains in movies have been used since the silent film age.

    Objective: To evaluate the hero-villain skin dichotomy in film by (1) identifying dermatologic findings of the all-time top 10 American film villains, (2) comparing these dermatologic findings to the all-time top 10 American film heroes quantitatively and qualitatively, and (3) analyzing dermatologic portrayals of film villains in depth.

    Design, Setting, And Participants: In this cross-sectional study, dermatologic findings for film heroes and villains in mainstream media were identified and compared quantitatively using a χ2 test with α < . Read More

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