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    Segmental pigmentation disorder: A rare form of cutaneous dyspigmentation.
    Caspian J Intern Med 2017 ;8(3):223-225
    Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Segmental pigmentation disorder (SegPD) is a rare type of cutaneous dyspigmentation. This hereditary disorder, first described some 20 years ago, is characterized by hypo and hyperpigmented patches on the trunk, extremities and less likely on the face and neck. These lesions are considered as a type of checkerboard pattern. Read More

    Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report.
    BMC Res Notes 2017 Sep 18;10(1):487. Epub 2017 Sep 18.
    Laboratoire Commun de Biologie et de Génétique Moléculaires, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France.
    Background: Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy are rare chronic liver disorders. Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution of the coproporphyrin isomers I and III in the urine. Intrahepatic cholestatic jaundice of pregnancy presents as pruritus, abnormal liver biochemistry and increased serum bile acids. Read More

    A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in PSENEN.
    Br J Dermatol 2017 Sep 18. Epub 2017 Sep 18.
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Dowling-Degos disease, featuring reticulate pigmentation, and familial hidradenitis suppurativa share many clinical features including autosomal dominant inheritance, flexural location and follicular defects. The co-existence of the two disorders was recently found to result from mutations in PSENEN, encoding protein presenilin enhancer gamma-secretase subunit. Here we report 4 additional families of Jewish Ashkenazi origin who presented with clinical features characteristic of both disorders. Read More

    The State of Ethnic Dermatology in Canada.
    J Cutan Med Surg 2017 Sep/Oct;21(5):464-466
    2 Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
    Approximately 30% of Canadians will be members of a visible minority by 2031. When dermatology became an independent medical discipline in the late 18th and early 19th centuries, most residents of Canada and the United States were of Northern European descent. Morphology and descriptions of dermatoses are based on patients with light skin. Read More

    Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique.
    J Am Acad Dermatol 2017 Oct;77(4):591-605
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Postinflammatory hyperpigmentation (PIH) commonly occurs after various endogenous and exogenous stimuli, especially in dark-skinned individuals. PIH is one of the most common complications of procedures performed using laser and other light sources. The severity of PIH is determined by the inherent skin color, degree and depth of inflammation, degree of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition. Read More

    Misuse of Topical Corticosteroids for Cosmetic Purpose in Antananarivo, Madagascar.
    Biomed Res Int 2017 21;2017:9637083. Epub 2017 Aug 21.
    Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.
    This cross-sectional study was conducted in Antananarivo, Madagascar, from June to September 2012. We aim to evaluate the misuse of TC on the face for cosmetic purpose and the adverse effects due to its application. A questionnaire-based analysis was done among females who use topical corticosteroids on the face for cosmetic purpose. Read More

    Seasonally-induced alterations of some facial signs in Caucasian women. Impact of a daily application of a photo-protective product.
    Int J Cosmet Sci 2017 Sep 8. Epub 2017 Sep 8.
    L'Oréal Research and Innovation, Chevilly-Larue, France.
    Objectives: These were two-fold: i) to record through standardized pictures, the possible changes in 14 facial signs induced, in a 6-month period, by the periodical shift from winter to summer in a group of 42 Caucasian women residing in Paris and ii) to appraise the preventive effects of a strong photo-protective product, daily applied to their face by an additional group (N=40) of women of same age-range and presenting same severities of facial signs in winter.

    Methods: Facial signs (structural and pigmentation-related) were graded in blind by a panel of 12 experts from photographs taken under standard conditions. Grading was performed under specific scales as previously published. Read More

    New Approach for the Derivation of Melanocytes from Induced Pluripotent Stem (Ips) Cells.
    J Invest Dermatol 2017 Sep 5. Epub 2017 Sep 5.
    Institute of Dermatology & Cutaneous Sciences, Sapporo, JAPAN.
    Induced pluripotent stem (iPS) cells have the ability to differentiate into multiple cell types in the body and have an unlimited growth potential. However, iPS cell-derived melanocytes produced by existing protocols have significant limitations in developing novel strategies for regenerative medicine and cell therapies of pigmentation disorders in humans, because they involve culture in media containing fetal bovine serum (FBS) and non-physiologic agents. In this study, we established a new in vitro approach to generate iPS cell-derived human melanocytes which have higher proliferation rates and increased melanin production compared to melanocytes prepared by previously reported approaches. Read More

    Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
    Int J Mol Sci 2017 Sep 7;18(9). Epub 2017 Sep 7.
    Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.
    N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells. Read More

    Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism.
    Food Res Int 2017 Oct 4;100(Pt 1):226-233. Epub 2017 Jul 4.
    State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China; New Zealand Institute of Natural Medicine Research, 8 Ha Crescent, Auckland 2104, New Zealand.
    Quercetin, a flavonoid compound, was found to inhibit both monophenolase and diphenolase activities of tyrosinase, and its inhibition against diphenolase activity was in a reversible and competitive manner with an IC50 value of (3.08±0.74)×10(-5)molL(-1). Read More

    The Standardized Extract of Juniperus communis Alleviates Hyperpigmentation in Vivo HRM-2 Hairless Mice and in Vitro Murine B16 Melanoma Cells.
    Biol Pharm Bull 2017 ;40(9):1381-1388
    College of Pharmacy, Pusan National University.
    In European folk medicine, the fruits of Juniperus communis are used in the treatment of skin-related disorders such as skin infection, itching, and psoriasis. Previously, we reported that the EtOAc fraction of J. communis (EAJC) contained tyrosinase inhibition properties in vitro non-cellular experiment. Read More

    Review of applications of microneedling in dermatology.
    Clin Cosmet Investig Dermatol 2017 8;10:289-298. Epub 2017 Aug 8.
    George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
    Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. Read More

    Melanocytes sense blue light and regulate pigmentation through the Opsin3.
    J Invest Dermatol 2017 Aug 22. Epub 2017 Aug 22.
    INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), team 12, Nice, France; Department of Dermatology, University hospital of Nice, France. Electronic address:
    The shorter wavelengths of the visible light have been recently reported to induce a long-lasting hyperpigmentation but only in melano-competent individuals. Here, we provide evidence demonstrating that opsin 3 (OPN3) is the key sensor in melanocytes responsible for hyperpigmentation induced by the shorter wavelengths of the visible light. The melanogenesis induced through OPN3 is calcium-dependent and further activates CAMKII followed by CREB, ERK, and p38 leading to the phosphorylation of MITF and ultimately to the increase of the melanogenesis enzymes: tyrosinase and dopachrome tautomerase (DCT). Read More

    Eyelash Trichomegaly: A Rare Presenting Feature of Systemic Lupus Erythematosus.
    Int J Trichology 2017 Apr-Jun;9(2):79-81
    Department of Dermatology, Venereology and Leprology, SHKM GMC, Nalhar, Haryana, India.
    An increase in length, curling, pigmentation, or thickness of eyelashes is termed eyelash trichomegaly. It may be inherited as an isolated trait or as a feature of a congenital syndrome such as Oliver-McFarlane syndrome or oculocutaneous albinism. Acquired conditions associated with eyelash trichomegaly include HIV infection, connective tissue disorders, and the administration of drugs such as cyclosporine and topical latanoprost. Read More

    Predictors of Sensitivity to Perceptual Learning in Children With Infantile Nystagmus.
    Invest Ophthalmol Vis Sci 2017 Aug;58(10):4162-4172
    Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Cognitive Neuroscience Department, Nijmegen, The Netherlands.
    Purpose: To identify predictors of sensitivity to perceptual learning on a computerized, near-threshold letter discrimination task in children with infantile nystagmus (idiopathic IN: n = 18; oculocutaneous albinism accompanied by IN: n = 18).

    Methods: Children were divided into two age-, acuity-, and diagnosis-matched training groups: a crowded (n = 18) and an uncrowded training group (n = 18). Training consisted of 10 sessions spread out over 5 weeks (grand total of 3500 trials). Read More

    New data on hyperpigmentation disorders.
    J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 5:18-21
    Department of Dermatology, Santo Amaro University Medical School, Santo Amaro, Brazil.
    Recently visible light (VL) and vascularization triggered by infrared light (IR) play a role in hyperpigmentation disorders of the skin. The aim of this article is to provide an update on the aetiology of hyperpigmentation disorders and means of prevention against UV, visible (VL) and infrared light (IR). The author conducted a literature review of the most recent data about hyperpigmentation disorders and means of prevention and protection. Read More

    The association between XPG polymorphisms and cancer susceptibility: Evidence from observational studies.
    Medicine (Baltimore) 2017 Aug;96(32):e7467
    aDepartment of Pathology, Jining No. 1 People's Hospital, Jining, Shandong bDepartment of Pathology, Changhai Hospital, Second Military Medical University, Shanghai cDepartment of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong dZhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, Wenzhou, Zhejiang eMolecular Epidemiology Laboratory, Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang fDepartment of Cardio-Thoracic Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.
    Background: Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. Read More

    Unusual Father-to-Daughter Transmission of Incontinentia Pigmenti Due to Mosaicism in IP Males.
    Pediatrics 2017 Sep 9;140(3). Epub 2017 Aug 9.
    Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," IGB-CNR, Naples, Italy;
    Incontinentia pigmenti (IP; Online Mendelian Inheritance in Man catalog #308300) is an X-linked dominant ectodermal disorder caused by mutations of the inhibitor of κ polypeptide gene enchancer in B cells, kinase γ (IKBKG)/ nuclear factor κB, essential modulator (NEMO) gene. Hemizygous IKBKG/NEMO loss-of-function (LoF) mutations are lethal in males, thus patients are female, and the disease is always transmitted from an IP-affected mother to her daughter. We present 2 families with father-to-daughter transmission of IP and provide for the first time molecular evidence that the combination of somatic and germ-line mosaicism for IKBKG/NEMO loss of function mutations in IP males resulted in the transmission of the disease to a female child. Read More

    Frictional Dermatosis in a Courier Driver.
    Open Access Maced J Med Sci 2017 Jul 20;5(4):541-542. Epub 2017 Jul 20.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Universitá Degli Studi "G. Marconi", Rome, Italy.
    Frictional hypermelanosis is an uncommon finding in Caucasians. We report the unusual case of 56-year-old male courier driver who developed linear and patchy hypermelanosis of the back caused by the driver's seat. Histology has included other pathologies. Read More

    Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells.
    Sci Rep 2017 Aug 4;7(1):7272. Epub 2017 Aug 4.
    Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
    In response to various types of injury, melanocyte stem cells (McSCs) located in the bulge of hair follicles can regenerate mature melanocytes for hair and skin pigmentation. How McSCs respond to injury, however, remains largely unknown. Here we show that after epilation of mice, McSCs regenerate follicular and epidermal melanocytes, resulting in skin and hair hyperpigmentation. Read More

    Vitiligo: Mechanistic insights lead to novel treatments.
    J Allergy Clin Immunol 2017 Sep 1;140(3):654-662. Epub 2017 Aug 1.
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Mass.
    Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting melanocyte regeneration. Recent basic and translational research studies have significantly improved our understanding of disease pathogenesis, which is now leading to emerging treatment strategies based on targeted therapy. Read More

    Autoimmune encephalitis associated with vitiligo?
    J Neuroimmunol 2017 Sep 7;310:14-16. Epub 2017 Jun 7.
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
    The autoimmune encephalitis can develop with or without an underlying tumor. For tumor-negative autoimmune encephalitis, the causes are still largely unknown. Here we presented three patients with autoimmune encephalitis accompanied with vitiligo. Read More

    Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.
    Molecules 2017 Aug 4;22(8). Epub 2017 Aug 4.
    Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, Urumqi 830011, China.
    Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Read More

    Beneficial Effect of Low Fluence 1,064 nm Q-Switched Neodymium:Yttrium-Aluminum-Garnet Laser in the Treatment of Senile Lentigo.
    Ann Dermatol 2017 Aug 21;29(4):427-432. Epub 2017 Jun 21.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo.

    Objective: To investigate the beneficial effect of low fluence 1,064 nm QS Nd:YAG laser in the treatment of senile lentigo on the face. Read More

    A single base deletion in the SLC45A2 gene in a Bullmastiff with oculocutaneous albinism.
    Anim Genet 2017 Oct 24;48(5):619-621. Epub 2017 Jul 24.
    Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.
    Oculocutaneous albinism type 4 (OCA4) in humans and similar phenotypes in many animal species are caused by variants in the SLC45A2 gene, encoding a putative sugar transporter. In dog, two independent SLC45A2 variants are known that cause oculocutaneous albinism in Doberman Pinschers and several small dog breeds respectively. For the present study, we investigated a Bullmastiff with oculocutaneous albinism. Read More

    [Clinical and genetic aspects of albinism].
    Presse Med 2017 Jul - Aug;46(7-8 Pt 1):648-654. Epub 2017 Jul 19.
    CHU de Bordeaux, service de dermatologie, 33076 Bordeaux, France.
    Albinism is a genetic disease affecting 1/17,000 person worldwide. It constitutes the second cause of congenital loss of visual acuity after optic atrophy. Albinism is heterogeneous both at the clinical and genetic levels. Read More

    Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis.
    Oecologia 2017 Jul 20. Epub 2017 Jul 20.
    Icelandic Institute of Natural History, Garðabær, Iceland.
    Melanins form the basis of animal pigmentation. When the sulphurated form of melanin, termed pheomelanin, is synthesized, the sulfhydryl group of cysteine is incorporated to the pigment structure. This may constrain physiological performance because it consumes the most important intracellular antioxidant (i. Read More

    Melasma: an Up-to-Date Comprehensive Review.
    Dermatol Ther (Heidelb) 2017 Jul 19. Epub 2017 Jul 19.
    Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
    Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Read More

    Iris Freckles a Potential Biomarker for Chronic Sun Damage.
    Invest Ophthalmol Vis Sci 2017 May;58(6):BIO174-BIO179
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Purpose: To investigate the role of sunlight exposure in iris freckles formation.

    Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Read More

    Precise role of dermal fibroblasts on melanocyte pigmentation.
    J Dermatol Sci 2017 Jul 1. Epub 2017 Jul 1.
    Engineering and Cutaneous Biology Laboratory, UMR 1098, University of Bourgogne Franche-Comté, Besançon, France; Department of Dermatology, University Hospital, Besançon, France.
    Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes. Read More

    Organ-sparing surgery for large cell calcifying Sertoli cell tumour in a patient with Carney complex.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
    Carney complex is a rare genetic disease characterised by a complex of myxomas, spotty pigmentation and endocrine overactivity. At diagnosis, about one-third of male patients presents with testicular tumours, namely large cell calcifying Sertoli cell tumours, which are often multicentric and/or bilateral and have a low malignant potential. Although radical orchiectomy is the gold standard for the treatment of testicular neoplasms, a conservative approach with partial orchiectomy or tumourectomy may be the best treatment option for these patients, allowing the preservation of endocrine function, fertility and body image. Read More

    Common and uncommon adverse cutaneous reactions to erlotinib: a study of 20 Chinese patients with cancer.
    Cutan Ocul Toxicol 2017 Aug 7:1-4. Epub 2017 Aug 7.
    d Department of Dermatology , the First Affiliated Hospital of Sun Yat-sen University , Guangzhou , P. R. China.
    Objective: This study presented common lesions with systemic toxicities and uncommon adverse cutaneous reactions such as anaphylactic dermatitis in patients undergoing treatment with erlotinib for the benefit of practicing dermatologists and oncologists.

    Methods: Adverse cutaneous reactions associated with erlotinib were reported in 20 Chinese patients with cancer.

    Results: Adverse cutaneous reactions reported included six cases of anaphylactic dermatitis, 12 cases of acneiform rash, nine cases of xerosis, five cases of nail changes and four cases of hair changes. Read More

    Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin.
    J Photochem Photobiol B 2017 Aug 29;173:551-559. Epub 2017 Jun 29.
    Department of Health Care & Science, Jeonju University, Jeonju 55069, Republic of Korea; Research Institute, Ato Q&A Corporation, Jeonju 55069, Republic of Korea. Electronic address:
    Humans have become exposed to another form of a trait which is ultraviolet B (UVB) radiation reaching the earth's surface. This has become a major source of oxidative stress that ultimately leads to inflammation, DNA damage, photoaging and pigmentation disorders etc. Although several studies have shown the photo-protective role of different grape parts like the fruits and seeds, little or no data demonstrating the in vivo photo-protective role of grape stem, which is the most discarded part of the grape are available. Read More

    Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells.
    Arch Pharm Res 2017 Jul 10;40(7):807-817. Epub 2017 Jul 10.
    College of Pharmacy, Chungbuk National University, 1 Chungdae, Seowon, Cheongju, Chungbuk, 28644, South Korea.
    Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz. Read More

    Adrenal crisis in metastatic breast cancer.
    BMJ Case Rep 2017 Jul 6;2017. Epub 2017 Jul 6.
    Interne I: Internistische Onkologie, Hämatologie u. Gastroenterologie, Ordensklinikum Linz Krankenhaus d. Barmherzigen Schwestern Linz Betriebs GmbH, Linz, Austria.
    A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment. Read More

    Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution.
    J Cosmet Dermatol 2017 Jul 3. Epub 2017 Jul 3.
    Arterra Bioscience srl, Napoli, Italy.
    Background: Skin whitening products, used for ages by Asian people for cultural and esthetic purposes, are very popular nowadays in Western countries as well, where the need to inhibit skin spots after sun exposure has become not only a cosmetic but also a health-related issue. Thus, the development of effective and safe depigmenting agents derived from natural products gets continuous attention by cosmetic brands and consumers.

    Objectives: The aim of this study was to determine the effects of two preparations, obtained from the hairy root cultures of the species Brassica rapa, on melanogenesis and the expression of the extracellular matrix proteins involved in a correct pigment distribution. Read More

    Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
    Angew Chem Int Ed Engl 2017 Aug 17;56(33):9812-9815. Epub 2017 Jul 17.
    Laboratory of Biophysical Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
    Tyrosinase-related protein 1 (TYRP1) is one of three tyrosinase-like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair. Difficulties with producing these enzymes in pure form have hampered the understanding of their activity and the effect of mutations that cause albinism and pigmentation disorders. Herein we show that the typical tyrosinase-like subdomain of TYRP1 contains two zinc ions in the active site instead of copper ions as found in tyrosinases, which explains why TYRP1 does not exhibit tyrosinase redox activity. Read More

    Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efficacy and Healthcare Resource Utilization for Seven Key Indications.
    Adv Ther 2017 Jun 28. Epub 2017 Jun 28.
    Mallinckrodt Pharmaceuticals Inc., Hampton, NJ, USA.
    Introduction: Repository corticotropin injection (RCI; H.P. Acthar(®) Gel; Mallinckrodt Pharmaceuticals Inc. Read More

    Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
    Arch Endocrinol Metab 2017 Jun 26. Epub 2017 Jun 26.
    Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
    Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Read More

    Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.
    Tumour Biol 2017 Jun;39(6):1010428317705131
    1 Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China.
    Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. Read More

    S100B: Correlation with Active Vitiligo Depigmentation.
    J Invest Dermatol 2017 Jul;137(7):1408-1410
    Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:
    Vitiligo, the most common depigmenting disorder, is caused by immune destruction of melanocytes by cytotoxic CD8(+) T cells. One weakness in vitiligo management is the lack of an assessment method for active depigmentation. Beginning with reports about increased S100B levels in different inflammatory and tissue damage processes, Speeckaert et al. Read More

    Clinical evaluation of the efficacy and safety of combined bipolar radiofrequency and optical energies vs. optical energy alone for the treatment of aging hands.
    Lasers Med Sci 2017 Aug 23;32(6):1387-1392. Epub 2017 Jun 23.
    Verner Clinic Tel Aviv, 39 Jerusalem St., POB 39, 55423, Kiriat Ono, Israel.
    Different treatment modalities are used for the treatment and esthetic improvement of aging hands. This study evaluated the efficacy and safety of a novel technology, which combines bipolar radio frequency (RF) and optical energies for the cosmetic treatment of aging hands. The objective of the study was to assess the efficacy, safety, tolerability, and patient satisfaction of combined bipolar radiofrequency and optical energies vs. Read More

    A reporter mouse model for in vivo tracing and in vitro molecular studies of melanocytic lineage cells and their diseases.
    Biol Open 2017 Aug 15;6(8):1219-1228. Epub 2017 Aug 15.
    Dept. of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Alterations in melanocytic lineage cells give rise to a plethora of distinct human diseases, including neurocristopathies, cutaneous pigmentation disorders, loss of vision and hearing, and melanoma. Understanding the ontogeny and biology of melanocytic cells, as well as how they interact with their surrounding environment, are key steps in the development of therapies for diseases that involve this cell lineage. Efforts to culture and characterize primary melanocytes from normal or genetically engineered mouse models have at times yielded contrasting observations. Read More

    Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism.
    Invest Ophthalmol Vis Sci 2017 Jun;58(7):3118-3126
    Pharmaceutical Chemistry I, PharmaCenter Bonn, University of Bonn, Bonn, Germany.
    Purpose: GPR143 regulates melanosome biogenesis and organelle size in pigment cells. The mechanisms underlying receptor function remain unclear. G protein-coupled receptors (GPCRs) are excellent pharmacologic targets; thus, we developed and applied a screening approach to identify potential GPR143 ligands and chemical modulators. Read More

    Gene therapy decreases seizures in a model of Incontinentia pigmenti.
    Ann Neurol 2017 Jul;82(1):93-104
    Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
    Objective: Incontinentia pigmenti (IP) is a genetic disease leading to severe neurological symptoms, such as epileptic seizures, but no specific treatment is available. IP is caused by pathogenic variants that inactivate the Nemo gene. Replacing Nemo through gene therapy might provide therapeutic benefits. Read More

    Isolation and Characterization of Isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo.
    Evid Based Complement Alternat Med 2017 24;2017:1401279. Epub 2017 May 24.
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
    Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. Read More

    Current and emerging treatments for vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):17-29
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Read More

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