35,064 results match your criteria Hypomelanosis of Ito


KIT as a therapeutic target for non-oncological diseases.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-, HM, Marseille, France.. Electronic address:

KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01637258183023
Publisher Site
http://dx.doi.org/10.1016/j.pharmthera.2018.12.008DOI Listing
December 2018
1 Read

Dermoscopic pre- and posttreatment evaluation in patients with androgenetic alopecia on platelet-rich plasma-A prospective study.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Dermatology, Venereology and Leprosy, A. J. Institute of Medical Sciences, Mangalore, India.

Background: Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders.

Objectives: To evaluate and study the role of dermoscopy in patients with androgenetic alopecia (AGA) pre- and posttreatment with platelet-rich plasma (PRP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12845DOI Listing
December 2018

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13856DOI Listing
December 2018
2 Reads

The different roles of 5-HT1A/2A receptors in fluoxetine ameliorated pigmentation of C57BL/6 mouse skin in response to stress.

J Dermatol Sci 2018 Oct 25. Epub 2018 Oct 25.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Background: 5-HT1A receptor was participated in fluoxetine induced melanogenesis in melanocytes and in normal C57BL/6 mice, but we know little about whether other 5-HT receptors are involved in regulation of fluoxetine promotes pigmentation.

Objective: To investigate the role of 5-HT receptors in regulation of fluoxetine ameliorates chronic unpredictable mild stress (CUMS) and chronic restraint stress (CRS) induce hypopigmentation in C57BL/6 mice.

Methods: CUMS and CRS were used to induce depigmentation in mice and evaluate the effect of fluoxetine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2018.10.002DOI Listing
October 2018

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hdi.12689DOI Listing
December 2018
4 Reads

Craniofacial skeleton of Mexican tetra (Astyanax mexicanus): As a bone disease model.

Dev Dyn 2018 Nov 19. Epub 2018 Nov 19.

Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E0W2, Canada.

A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbours many favourable constructive traits (i. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dvdy.4
Publisher Site
http://dx.doi.org/10.1002/dvdy.4DOI Listing
November 2018
4 Reads

Possible hints and pitfalls in diagnosing Peutz-Jeghers syndrome.

J Pediatr Endocrinol Metab 2018 Dec;31(12):1381-1386

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Background Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal polyposis, mucocutaneous pigmentation and cancer predisposition. Patients with PJS can develop large calcifying Sertoli cell tumors (LCSTs). Case presentation A patient presented at 3 years of age with delayed development, hypermobility and later also with tall stature and advanced bone age. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/jpem.ahead-of-print/jpem-201
Publisher Site
http://dx.doi.org/10.1515/jpem-2018-0265DOI Listing
December 2018
9 Reads

The inhibition of melanogenesis via the PKA and ERK signaling pathways by extract in B16F10 melanoma cells and artificial human skin equivalents.

J Microbiol Biotechnol 2018 Nov 2. Epub 2018 Nov 2.

Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul, Republic of Korea.

Abnormal melanin synthesis results in several hyperpigmentary disorders such as freckles, melanoderma, age spots, and other hyperpigmentation syndromes. In this study, we investigated the anti-melanogenic effects of an extract from the microalgae (CE) and potential mechanisms responsible for its inhibitory effect in B16F10, normal human epidermal melanocyte cells, and human skin-equivalent models. The CE extract showed significant dose-dependent inhibitory effects on α-melanocyte-stimulating hormone-induced melanin synthesis in cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4014/jmb.1810.10008DOI Listing
November 2018
4 Reads

Sub-lethal effects induced by a mixture of different pharmaceutical drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw, 1802) (Anura, ranidae) tadpoles.

Environ Sci Pollut Res Int 2018 Nov 8. Epub 2018 Nov 8.

Post-Graduation Program in Conservation of Cerrado Natural Resources - Biological Research Laboratory, Goiano Federal Institute-Urutaí Campus, Urutaí, GO, Brazil.

The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a "drug mix" (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of different medication classes (antibiotic, anti-inflammatory, antidepressant, anxiolytic, analgesic, and antacid drugs)-at environmentally relevant concentrations-may change their oral morphology, trigger behavioral disorders, and have mutagenic effects on erythrocyte cells. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11356-018-3656-9
Publisher Site
http://dx.doi.org/10.1007/s11356-018-3656-9DOI Listing
November 2018
7 Reads

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment.

Int J Nanomedicine 2018 15;13:6465-6479. Epub 2018 Oct 15.

Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia,

Introduction: Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation. In this study, KMO was formulated in an oil-in-water nanoemulsion as a carrier for better penetration into the skin.

Methods: The nanoemulsion was prepared by using high and low energy emulsification technique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S171532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198893PMC
December 2018
4 Reads

Stimulation of melanin synthesis in melanoma cells by cold plasma.

Biol Chem 2018 Dec;400(1):101-109

Department Plasma Life Science, Leibniz-Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, D-17489 Greifswald, Germany.

Skin color is derived from epidermal melanocytes that contain specialized organelles in which melanin is formed. The formation of melanin is a well-orchestrated process, and reactive oxygen species (ROS) play a role in numerous enzymatic conversions, such as the reactions catalyzed by tyrosinase and tyrosine hydroxylase. Currently, there is ample evidence that cold plasma exerts biological effects on cells through the impact of ROS and reactive nitrogen species (RNS). Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/bchm.ahead-of-print/hsz-2018
Publisher Site
http://dx.doi.org/10.1515/hsz-2018-0223DOI Listing
December 2018
11 Reads

[Cervico-occipital junction malformation and vitiligo].

Pan Afr Med J 2018 20;30:146. Epub 2018 Jun 20.

Departement of Dermatology, Military Hospital My Ismail, Meknes, Morocco.

Vitiligo is a relatively common multifactorial polygenetic dermatosis (0.5%-2% of general population) characterized by segmental or nonsegmental cutaneous depigmentation. Chiari malformation is a congenital cervico-occipital junction disease characterized by a migration of a part of the cerebellum through the foramen magnum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.30.146.15610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201618PMC
November 2018
5 Reads

Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.

Bioorg Med Chem 2018 Nov 19;26(21):5672-5681. Epub 2018 Oct 19.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, South Korea. Electronic address:

Pigmentation disorders are attributed to excessive melanin which can be produced by tyrosinase. Therefore, tyrosinase is supposed to be a vital target for the treatment of disorders associated with overpigmentation. Based on our previous findings that an (E)-β-phenyl-α,β-unsaturated carbonyl scaffold can play a key role in the inhibition of tyrosinase activity, and the fact that cinnamic acid is a safe natural substance with a scaffolded structure, it was speculated that appropriate cinnamic acid derivatives may exhibit potent tyrosinase inhibitory activity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896183146
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2018.10.014DOI Listing
November 2018
7 Reads

Treatment of Moderate Acne Vulgaris in Fitzpatrick Skin Type V or VI: Efficacy and Tolerability of Fixed Combination Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% Gel.

J Drugs Dermatol 2018 Oct;17(10):1107-1112

Background: Acne vulgaris (acne) is the most common skin disease in patients who have darker skin with most frequent sequelae of post inflammatory hyperpigmentation (PIH).

Methods: Open label study in 20 patients (mean age 32 years) with Fitzpatrick Skin Type V or VI and with moderate facial acne treated with clindamycin phosphate 1.2%/benzoyl peroxide 3. Read More

View Article

Download full-text PDF

Source
October 2018
7 Reads

Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians.

Lasers Surg Med 2018 Oct 25. Epub 2018 Oct 25.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background And Objectives: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/lsm.23028
Publisher Site
http://dx.doi.org/10.1002/lsm.23028DOI Listing
October 2018
15 Reads

Differential corneal involvement in xeroderma pigmentosum.

Authors:
Sunita Chaurasia

Indian J Ophthalmol 2018 Nov;66(11):1623

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijo.IJO_667_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213660PMC
November 2018

Corneal edema in xeroderma pigmentosa.

Authors:
Sunita Chaurasia

Indian J Ophthalmol 2018 Nov;66(11):1622

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijo.IJO_469_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213657PMC
November 2018

Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.

Eur J Med Chem 2019 Jan 15;161:78-92. Epub 2018 Oct 15.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, 46241, South Korea. Electronic address:

Of the three enzymes that regulate the biosynthesis of melanin, tyrosinase and its related proteins TYRP-1 and TYRP-2, tyrosinase is the most important because of its ability to limit the rate of melanin production in melanocytes. For treating skin pigmentation disorders caused by an excess of melanin, the inhibition of tyrosinase enzyme is by far the most established strategy. Cinnamic acid is a safe natural product with an (E)-β-phenyl-α,β-unsaturated carbonyl motif that we have previously shown to play an important role in high tyrosinase inhibition. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02235234183088
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2018.10.025DOI Listing
January 2019
9 Reads

[Scleroatrophic extragenital lichen and inflammatory vitiligo in children: a rare association].

Pan Afr Med J 2018 29;30:75. Epub 2018 May 29.

Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN SINA, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions evolving over 6 months. Read More

View Article

Download full-text PDF

Source
http://www.panafrican-med-journal.com/content/article/30/75/
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.75.13954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191275PMC
October 2018
4 Reads

A curated gene list for expanding the horizons of pigmentation biology.

Pigment Cell Melanoma Res 2018 Oct 19. Epub 2018 Oct 19.

Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Over the past century, studies of human pigmentary disorders along with mouse and zebrafish models have shed light on the many cellular functions associated with visible pigment phenotypes. This has led to numerous genes annotated with the ontology term "pigmentation" in independent human, mouse, and zebrafish databases. Comparisons among these datasets revealed that each is individually incomplete in documenting all genes involved in integument-based pigmentation phenotypes. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pcmr.12743
Publisher Site
http://dx.doi.org/10.1111/pcmr.12743DOI Listing
October 2018
5 Reads

Usefulness of the skin biopsy as a tool in the diagnosis of silvery hair syndrome.

Pediatr Dermatol 2018 Nov 18;35(6):780-783. Epub 2018 Oct 18.

Department of Dermatology, National Institute of Pediatrics, Mexico City, Mexico.

Background/objectives: Silvery hair syndrome is a rare, autosomal-recessive entity characterized by silvery gray hair, eyebrows, and eyelashes and may be associated or not with immunologic or neurologic alterations. Two main types have been recognized: Chediak-Higashi syndrome and Griscelli syndrome. Hair shaft examination under light microscopy has been a useful tool to differentiate Chediak-Higashi syndrome from Griscelli syndrome, although distribution of melanin varies according to hair color related to ethnicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13624DOI Listing
November 2018
1 Read

Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish ().

Int J Mol Sci 2018 Oct 17;19(10). Epub 2018 Oct 17.

Department of Medical Biotechnology (BK21 Plus Team), Dongguk University, Goyang-si 10326, Korea.

Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effects of pulsed electromagnetic fields (PEMFs) on the pigmentation of zebrafish () in vivo. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1422-0067/19/10/3211
Publisher Site
http://dx.doi.org/10.3390/ijms19103211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214121PMC
October 2018
3 Reads

CCN proteins as potential actionable targets in scleroderma.

Exp Dermatol 2018 Oct 17. Epub 2018 Oct 17.

University of Bordeaux, Inserm, BMGIC, UMR1035, Bordeaux, France.

Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic targets. CCN proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3 and WISP1-2-3 as CCN4-5-6) are a family of secreted matricellular proteins implicated in major cellular processes such as cell growth, migration, differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13806DOI Listing
October 2018
11 Reads

Effects of six compounds with different chemical structures on melanogenesis.

Chin J Nat Med 2018 Oct;16(10):766-773

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D, piperine, and 6-benzylaminopurine. We determined their effectiveness, toxicity, and mechanism of action for stimulating pigmentation in B16F10 melanoma cells and in a zebrafish model. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18755364183011
Publisher Site
http://dx.doi.org/10.1016/S1875-5364(18)30116-XDOI Listing
October 2018
7 Reads

Hyperpigmented Macule on the Palm and Diminished Sensation.

JAMA 2018 Nov;320(19):2029-2030

Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, Michigan.

View Article

Download full-text PDF

Source
http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
Publisher Site
http://dx.doi.org/10.1001/jama.2018.14701DOI Listing
November 2018
1 Read

The triennial International Pigment Cell Conference (IPCC).

J Transl Med 2018 Oct 3;16(1):252. Epub 2018 Oct 3.

Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 5200 North Lake Road, Merced, CA, 95343, USA.

The International Federation of Pigment Cell Societies (IFPCS) held its XXIII triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in August 2017. The goal of the summit was to provide a venue promoting a vibrant interchange among leading basic and clinical researchers working on leading-edge aspects of melanocyte biology and disease. The philosophy of the meeting, entitled Breakthroughs in Pigment Cell and Melanoma Research, was to deliver a comprehensive program in an inclusive environment fostering scientific exchange and building new academic bridges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12967-018-1609-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169034PMC
October 2018
2 Reads

Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo.

Theranostics 2018 9;8(17):4620-4632. Epub 2018 Sep 9.

Department of Dermatology, Ajou University School of Medicine, Suwon, 443-721, Korea.

Cutaneous ageing is an important extrinsic process that modifies the pigmentary system. Because cellular senescence is a fundamental ageing mechanism, we examined the role of senescent cells in ageing pigmentation. Biopsies obtained from senile lentigo and perilesional normal skin were assayed for a marker of cellular senescence, p16. Read More

View Article

Download full-text PDF

Source
http://www.thno.org/v08p4620.htm
Publisher Site
http://dx.doi.org/10.7150/thno.26975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160768PMC
September 2018
8 Reads

Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbits.

EBioMedicine 2018 Oct 28;36:517-525. Epub 2018 Sep 28.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun 130062, China. Electronic address:

Background: Oculocutaneous albinism (OCA) is a group of autosomal recessive disorders characterized by reduced melanin that are caused by mutations in the gene encoding tyrosinase (TYR), which is the rate-limiting enzyme in the production of the pigment melanin. Many studies or meta-analyses have suggested an association between the TYR T373K SNP and OCA1, but there is limited biochemical and genetic evidence to support this association.

Methods: We overexpressed TYR-WT and TYR-T373K mutants on HK293T cells and tested the changes of melanin production and tyrosinase activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2018.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197749PMC
October 2018

Evaluation of supportive and barrier-protective skin care products in the daily prevention and treatment of cutaneous toxicity during systemic chemotherapy.

Onco Targets Ther 2018 17;11:5865-5872. Epub 2018 Sep 17.

La Roche-Posay Dermatological Laboratory, Levallois-Perret, France,

Introduction: The purpose of this multicenter, prospective, observational, open-label study was to evaluate the use and tolerability of dermo-cosmetic products in preventing skin reactions associated with cancer treatments.

Patients And Methods: A 12-product kit was supplied to patients before chemotherapy began and was to be used throughout the treatment phase. Cutaneous adverse events were evaluated at each treatment session. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/evaluation-of-supportive-and-barri
Publisher Site
http://dx.doi.org/10.2147/OTT.S155438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149940PMC
September 2018
4 Reads

Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages.

Chemosphere 2019 Jan 19;214:184-194. Epub 2018 Sep 19.

College of Sciences, China Agricultural University, Beijing, People's Republic of China. Electronic address:

The agricultural use of succinate dehydrogenase inhibitor (SDHI) fungicides has increased dramatically in the US and Europe. As the SDHI fungicides, boscalid, flutolanil and thifluzamide had been reported to induce a series of toxic effects on zebrafish. However, the toxic effects of penthiopyrad on zebrafish have not been reported yet. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535183177
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2018.09.117DOI Listing
January 2019
6 Reads

Vitamin B Deficiency Induces Imbalance in Melanocytes Homeostasis-A Cellular Basis of Hypocobalaminemia Pigmentary Manifestations.

Int J Mol Sci 2018 Sep 19;19(9). Epub 2018 Sep 19.

Department of Pharmaceutical Chemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Vitamin B deficiency causes significant changes in cellular metabolism leading to various clinical symptoms, such as hematological, psychiatric, and neurological disorders. We hypothesize that skin pigmentation disorders may be a diagnostically important manifestation of vitamin B deficiency, however the cellular and molecular mechanisms underlying these effects remain unknown. The aim of this study was to examine the effect of vitamin B deficiency on melanocytes homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19092845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163934PMC
September 2018

Approach to Skin Lightening in Patients With Melasma.

Authors:
Philip R Cohen

J Drugs Dermatol 2018 Sep;17(9):1018

I read with interest the informative article by Spencer et al1 that describes the efficacious use as a novel skin lightening agent (LumaPro-C) for the treatment of patients with melasma. Read More

View Article

Download full-text PDF

Source
September 2018
2 Reads

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.

J Drugs Dermatol 2018 Sep;17(9):970-973

Introduction: Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent, moisturizer, and an aid for wound healing. In this study, we explore the efficacy of topical EGF in the treatment of melasma. Read More

View Article

Download full-text PDF

Source
September 2018
32 Reads

Managing Seborrheic Keratosis: Evolving Strategies and Optimal Therapeutic Outcomes.

J Drugs Dermatol 2018 Sep;17(9):933-940

Seborrheic keratosis (SK) is the most common skin tumor seen by dermatologists in everyday practice. Although the lesions are mostly benign, many patients still elect to have asymptomatic SK removed. The historical standards of treatment are cryosurgery and electrocautery, two surgical options that are effective at lesion removal but have high rates of postoperative adverse events such as treatment-site scarring and pigmentary alterations. Read More

View Article

Download full-text PDF

Source
September 2018
5 Reads

Unilateral retinoblastoma with contralateral isolated choroidal Melanocytosis: case report of an unexpected presentation.

BMC Ophthalmol 2018 Sep 17;18(1):251. Epub 2018 Sep 17.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Congenital ocular melanocytosis has been shown to be extremely uncommon in studies of numerous infants and children with retinoblastoma and disorders such as retinopathy of prematurity.

Case Presentation: A 33-month-old Caucasian boy presented with a solid white predominantly endophytic retinoblastoma filling most of the nasal aspect of the fundus and extensive vitreous seeding. Fundus exam of the contralateral eye showed a broad-based flat melanotic area of the choroid extending from the subfoveal region to the ora serrata temporally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-018-0916-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142679PMC
September 2018
1 Read

Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics.

Med Sci Monit 2018 Sep 16;24:6489-6497. Epub 2018 Sep 16.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).

BACKGROUND Multiple studies have implicated a role for CD8+T cell-mediated immune response to autoantigens in vitiligo. However, the antigen-specific T lymphocyte reactivity against the peptide epitopes is diverse among different world populations. This study aimed to identify the risk HLA-A allele in vitiligo and study CD8+ T cell reactivity to 5 autoantigenic peptides in Han Chinese populations, and to analyze the association of CD8+ T cell reactivity with disease characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.910515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154310PMC
September 2018

Unilateral cataract associated with eyelid ash-leaf macule in tuberous sclerosis complex.

BMJ Case Rep 2018 Sep 15;2018. Epub 2018 Sep 15.

Department of Ophthalmology, JIPMER, Puducherry, India.

A 9-month-old male child with tuberous sclerosis complex presented with ash-leaf macules on the left periocular region and ipsilateral dense cataract. Fundus showed retinal astrocytic hamartomas. This case is reported for unilaterality of congenital cataract on the same side of eyelid ash-leaf macule in tuberous sclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-224923DOI Listing
September 2018
8 Reads

Characterization of sulfuretin as a depigmenting agent.

Fundam Clin Pharmacol 2018 Sep 14. Epub 2018 Sep 14.

Qingdao Municipal Hospital, No. 21 Anhui Road, Qingdao, 266011, China.

Sulfuretin is a major flavonoid found in Rhus verniciflua and carries anti-oxidative and anti-inflammatory properties, but its potential use in the control of skin pigmentation is unknown. The purpose of the present study was to elucidate sulfuretin as a new active compound inhibiting melanogenesis and the underlying mechanism. The effects of sulfuretin on melanin production, tyrosinase activity, cAMP level, and MITF expression were examined in murine melanoma B16 cells challenged with forskolin or α-MSH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/fcp.12414DOI Listing
September 2018

Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact.

Int J Mol Sci 2018 Sep 8;19(9). Epub 2018 Sep 8.

L'Oréal Research and Innovation, 1 avenue Eugène Schueller, 93601 Aulnay-sous-Bois, France.

Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting from constitutive pigmentation variability. This paper will review the characterization of skin pigmentation diversity with a focus on the most recent data on the genetic basis of skin pigmentation, and the various methodologies for skin color assessment. Then, melanocyte activity and amount, type and distribution of melanins, which are the main drivers for skin pigmentation, are described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19092668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163216PMC
September 2018
1 Read

Trichoscopy in Hair Shaft Disorders.

Dermatol Clin 2018 Oct 16;36(4):421-430. Epub 2018 Aug 16.

Department of Dermatology, Medical University of Warsaw, Pawinskiego 5, 02-106, Warszawa, Poland.

Trichoscopy allows analyzing the structure and size of growing hair shafts in their natural environment in children and adults. The method replaces light microscopy, which requires pulling of multiple hairs for investigation. In monilethrix, trichoscopy shows uniform elliptical nodosities with intermittent constrictions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
Publisher Site
http://dx.doi.org/10.1016/j.det.2018.05.009DOI Listing
October 2018
13 Reads

Yellow nail syndrome with chylothorax after coronary artery bypass grafting.

J Cardiothorac Surg 2018 Sep 11;13(1):93. Epub 2018 Sep 11.

Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Background: Yellow nail syndrome is a rare condition considered secondary to functional anomalies of lymphatic drainage. Yellow nail syndrome is diagnosed through the triad of intrathoracic findings (30% being pleural effusions), nail discoloration, and lymphedema, with any two features sufficient for diagnosis. We report the second case of post-operative yellow nail syndrome. Read More

View Article

Download full-text PDF

Source
https://cardiothoracicsurgery.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s13019-018-0784-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131875PMC
September 2018
4 Reads

Progression of retinal pigmentation mimicking unilateral retinitis pigmentosa after bilateral pars planitis: a case report.

BMC Ophthalmol 2018 Sep 10;18(1):242. Epub 2018 Sep 10.

Department of Ophthalmology, Hospital de la Santa Creu i de Sant Pau, Barcelona, Spain.

Background: To report our findings in a young patient with unilateral retinitis pigmentosa (RP)-like appearance who developed pigmentary changes in his left retina after an episode of bilateral pars planitis.

Case Presentation: A 17-year-old man presented with 6 months of blurry vision in both eyes. He was diagnosed with bilateral pars planitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-018-0814-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131731PMC
September 2018
1 Read

Evaluating age-related changes of some facial signs among men of four different ethnic groups.

Int J Cosmet Sci 2018 Oct;40(5):502-515

RB Consult, Bievres, France.

Background: The alterations of some facial characteristics, with age, in men of different ethnic groups are a scarcely studied topic.

Objective: To illustrate and grade, among men of four different ethnic descents (Asians, African-Americans, Caucasians, Indians), aged 18-80 year, the changes in the severity of some facial signs occurring with age.

Methods: Digital Photographs (full face, profile, 45°) of 1058 subjects were taken under standard conditions of lightning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ics.12492DOI Listing
October 2018
1 Read

Use of vismodegib for the treatment of multiple basal cell carcinomas in a patient with xeroderma pigmentosum.

Pediatr Dermatol 2018 Nov 3;35(6):e334-e336. Epub 2018 Sep 3.

1st University Department of Dermatology - Venereology, "Andreas Sygros" Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

A female patient with xeroderma pigmentosum and multiple basal cell carcinomas was treated with a hedgehog pathway inhibitor (vismodegib), which successfully treated the majority of her basal cell carcinomas while preventing the appearance of new lesions. The sum diameter of lesions showed a 61% decrease after 16.5 months of treatment, although after 18. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13610DOI Listing
November 2018
1 Read

Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation.

Transplant Proc 2018 Sep 11;50(7):2176-2178. Epub 2018 Apr 11.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders.

Material And Methods: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes. The study comprised standard case taking and physical examination of the patient, including detailed intraoral and extraoral stomatological examinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.04.003DOI Listing
September 2018
11 Reads

A global consensus statement on ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis.

Int J Dermatol 2018 Sep 3. Epub 2018 Sep 3.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation are several acquired macular hyperpigmentation disorders of uncertain etiology described in literature. Most of the published studies on these disorders are not exactly comparable, as there are no clear definitions and different regions in the world describe similar conditions under different names. A consensus on the terminology of various morphologies of acquired macular pigmentation of uncertain etiology was a long-felt need. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14189DOI Listing
September 2018
18 Reads
1.230 Impact Factor

Terminal osseous dysplasia presenting with intracytoplasmic inclusion bodies in digital fibromas.

Pediatr Dermatol 2018 Nov 31;35(6):e353-e356. Epub 2018 Aug 31.

Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

Terminal osseous dysplasia is a rare, X-linked syndrome, presumptively embryonic lethal in males, which has recently been described with highly characteristic skin findings. The presence of intracytoplasmic inclusion bodies in fibroblasts has been considered an exclusive finding of infantile digital fibromatosis. This is the first report documenting digital fibromas with intracytoplasmic inclusion bodies in a classic case of terminal osseous dysplasia. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pde.13656
Publisher Site
http://dx.doi.org/10.1111/pde.13656DOI Listing
November 2018
3 Reads

Phylloid terminal hair nevus: A unique clinical entity.

Pediatr Dermatol 2018 Nov 28;35(6):e404-e405. Epub 2018 Aug 28.

Department of Dermatology, Columbia University Medical Center, New York, New York.

We present a case of an otherwise healthy infant with a localized patch of phylloid hypopigmentation bordered by terminal hairs on the back. We believe that this is a unique clinical entity and propose the term "phylloid terminal hair nevus." We believe that this is a localized form of phylloid hypomelanosis that is not associated with extracutaneous abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13616DOI Listing
November 2018

Short stature and growth hormone deficiency: unexpected manifestations of McCune-Albright syndrome.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Radiology, Princess Marina Hospital, Gaborone, Botswana.

McCune-Albright syndrome (MAS) is a rare disease characterised by triad of monostotic or polyostotic fibrous dysplasia, café au-lait skin spots and a variety of endocrine disorders; precocious puberty (PP) being the most common presenting symptom in female patients. Hyperfunction endocrinopathies including hyperthyroidism, growth hormone excess and cortisol excess are typical presentations in MAS. We present a case of 21-year-old woman with clinical and radiological characteristics of MAS triad; she presented with short stature which was attributed to both growth hormone deficiency and PP. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22570
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-225709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119388PMC
August 2018
8 Reads