35,262 results match your criteria Hypomelanosis of Ito


Successful Treatment of Freckles by Alex Trivantage Laser Wavelight 755 nm in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):287-290. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Objectives: This study aims to evaluate the effectiveness of Alex Trivantage laser wavelength 755 nm (ATL) in the treatment of freckles at Hanoi Hospital of Dermatology and Venereology, Vietnam.

Patients And Methods: A group of 30 patients with freckles were treated by ATL (Alex Trivantage-Candela Co America) with spots size 3 mm, wavelength 755 mm, and energy 5-6 j/cm. All the patients were treated 2 times with 4-weeks interval. Read More

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http://dx.doi.org/10.3889/oamjms.2019.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364722PMC
January 2019

Evolution of the Picosecond Laser: A Review of Literature.

Dermatol Surg 2019 Feb;45(2):183-194

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.

Background: Picosecond pulse duration lasers (PS) have altered the field of dermatology. PS were initially used in tattoo removal, to optimize efficacy and reduce side effects with nanosecond domain lasers. More recently, they have been demonstrated to be effective in the treatment of pigmentary disorders, acne scarring, and photoaging. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001697DOI Listing
February 2019
2 Reads

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression.

Nat Commun 2019 01 23;10(1):391. Epub 2019 Jan 23.

Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, 80045, CO, USA.

Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean 34. Read More

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http://dx.doi.org/10.1038/s41467-019-08337-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344500PMC
January 2019
1 Read
10.742 Impact Factor

Prevalence of hypovitaminosis D in India & way forward.

Indian J Med Res 2018 Nov;148(5):548-556

Centre for Promotion of Nutrition Research and Training with Special Focus on North East, Tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

Deficiency of vitamin D or hypovitaminosis D is widespread irrespective of age, gender, race and geography and has emerged as an important area of research. Vitamin D deficiency may lead to osteoporosis (osteomalacia in adults and rickets in children) along with calcium deficiency. Its deficiency is linked with low bone mass, weakness of muscles and increased risk of fracture. Read More

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http://www.ijmr.org.in/text.asp?2018/148/5/548/249984
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http://dx.doi.org/10.4103/ijmr.IJMR_1807_18DOI Listing
November 2018
3 Reads

An herbal H2 blocker in melasma treatment.

Curr Drug Discov Technol 2019 Jan 21. Epub 2019 Jan 21.

Health center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Melasma is a skin pigmentation disorder that remains resistant to available therapies. The exact cause of melasma is unknown. Histamine is an inflammatory factor. Read More

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http://dx.doi.org/10.2174/1570163816666190121145653DOI Listing
January 2019

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
4 Reads

Pigmentation Disorders in the Elderly.

Drugs Aging 2019 Mar;36(3):235-245

Division of Dermatology, Dell Medical School, University of Texas at Austin, 1400 N. I-35, Suite C2.470, Austin, TX, 78701, USA.

Aging skin is subject to morphological change due to both intrinsic (skin tone, genetics, endogenous hormones) and extrinsic (chronic sun exposure, medications, exogenous pigments) factors. The broad spectrum of transformation includes both hypo- and hyperpigmentation. Although cutaneous pigmentary disorders are common in younger individuals, certain disorders are more prevalent in the geriatric population. Read More

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http://dx.doi.org/10.1007/s40266-018-00633-wDOI Listing

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report.

BMC Gastroenterol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten genetic subtypes of this autosomal recessive condition have been described to date. Some patients with Hermansky-Pudlak syndrome type 1, 4, or 6 develop Crohn's-like inflammatory bowel disease at any age including early childhood, but most often in adolescence or young adulthood. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0929-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329123PMC
January 2019
10 Reads

Mushroom Tyrosinase-Based Enzyme Inhibition Assays Are Not Suitable for Bioactivity-Guided Fractionation of Extracts.

J Nat Prod 2019 Jan 10;82(1):136-147. Epub 2019 Jan 10.

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI) , University of Innsbruck , Innrain 80/82 , 6020 Innsbruck , Austria.

Tyrosinase (Tyr) catalyzes the rate-limiting step of melanogenesis in human skin and is thus the main target for treating pigmentation disorders today. This has led to an increased research interest in Tyr inhibitors during the last decades, with a frequent focus on polyphenols. In the early stages of drug discovery, it is typical to avoid the high costs of human Tyr by using the more economic mushroom tyrosinase (mh-Tyr). Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00847DOI Listing
January 2019
1 Read

A closer look at the role of the dermatologist in championing total women's health through the dermatology gateway.

Authors:
P E Grimes

Int J Womens Dermatol 2018 Dec 15;4(4):189-192. Epub 2018 Nov 15.

Women's Dermatologic Society, Milwaukee, Wisconsin.

New data collected by the Women's Dermatologic Society (WDS) through a membership survey conducted in August 2018 reflect the key role of the dermatologist in championing the overall health of the total woman through the dermatology gateway. These meaningful results provide a first-ever metric glimpse into the myriad systemic/internal diseases, disorders, and conditions that WDS dermatologists detect and diagnose in female dermatology patients and the wide scope of our collaborations with other physician specialists to manage complex, underlying medical conditions. Insightful perspectives from medical and health experts outside of dermatology address the importance of teamwork, reaffirm the unique role that dermatologists play on the medical team, and underscore the vital importance of our proclivity toward collaboration, the latter of which is shown to be significant according to the WDS data. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322156PMC
December 2018

Was the Last Ice Age dusty climate instrumental in spreading of the three "Celtic" diseases (hemochromatosis, cystic fibrosis and palmar fibromatosis)?

Authors:
Sven Kurbel

Med Hypotheses 2019 Jan 20;122:134-138. Epub 2018 Nov 20.

Faculty of Dental Medicine and Health Osijek, Crkvena 21, HR-31000 Osijek, Croatia; Polyclinic Aviva, Nemetova 2, Zagreb, Croatia. Electronic address:

Cystic fibrosis, hereditary hemochromatosis and palmar fibromatosis are often described as "Celtic", based on their contemporary prevalence. The former two are among genetically defined disorders that seem to provide survival advantages to heterozygote individuals, while severe health problems happen in homozygote mutation carriers. Although palmar fibromatosis has no defined mutations, its prevalence has been linked to the prevalence of Y-Chromosome Haplogroup I that expanded after the Last Ice Age, thus making th distribution of all three "Celtic" diseases dependent on the global climate from 40 to 8 Kya. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.11.006DOI Listing
January 2019
2 Reads

Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma.

Medicine (Baltimore) 2018 Dec;97(52):e13810

Skin Cancer Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola.

Rationale: The introduction of immune check-point inhibitors (ICIs) in the treatment of solid neoplasms is associated with the need to know and manage a new type of side effects that are commonly defined immune-mediated adverse events. Dermatologic immune-mediated adverse events are relatively common. Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs in particular in patients with malignant melanoma, probably due to a common autoimmune mechanism against both melanoma cells and normal melanocytes. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314787PMC
December 2018
3 Reads

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):6067-6073

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, United States.

Purpose: Complete deficiency of microphthalmia transcription factor (MITF) in Mitfmi-vga9/mi-vga9 mice is associated with microphthalmia, retinal dysplasia, and albinism. We investigated the ability of dopachrome tautomerase (DCT) promoter-mediated inducible ectopic expression of Mitf-M to rescue these phenotypic abnormalities.

Methods: A new mouse line was created with doxycycline-inducible ectopic Mitf-M expression on an Mitf-deficient Mitfmi-vga9 background (DMV mouse). Read More

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http://dx.doi.org/10.1167/iovs.18-25186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314104PMC
December 2018
1 Read

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging

J Drugs Dermatol 2018 Dec;17(12):1310-1315

Objective: To evaluate the safety and efficacy of ISDINCEUTICS Melaclear® serum (Barcelona, Spain) on skin brightness, skin quality, and signs of facial aging. Design: This was a single-center, observational, open label, prospective clinical study. Ten healthy females (ages 30-70) with moderate signs of facial aging and moderate photodamage (hyperpigmentation and/or sun spots) were enrolled. Read More

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December 2018
11 Reads

[Friction melanosis and mode of dress].

Pan Afr Med J 2018 17;30:215. Epub 2018 Jul 17.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

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http://www.panafrican-med-journal.com/content/article/30/215
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http://dx.doi.org/10.11604/pamj.2018.30.215.16239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294982PMC
January 2019
1 Read

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
7 Reads

Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis.

Int J Mol Med 2019 Feb 11;43(2):1105-1113. Epub 2018 Dec 11.

Cell and Matrix Research Institute, Kyungpook National University‑Center for Nonlinear Dynamics, School of Life Sciences, Brain Korea 21 Plus Kyungpook National University Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.

Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono‑ and di‑methylated ninth lysine of histone 3 and belongs to the Jumonji domain‑containing group of demethylases. Kdm3a serves roles during various biological and pathophysiological processes, including spermatogenesis and metabolism, determination of sex, androgen receptor‑mediated transcription and embryonic carcinoma cell differentiation. In the present study, physiological functions of Kdm3a were evaluated during embryogenesis of Xenopus laevis. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4024DOI Listing
February 2019

Biology of human melanocyte development, Piebaldism, and Waardenburg syndrome.

Pediatr Dermatol 2019 Jan 18;36(1):72-84. Epub 2018 Dec 18.

University of Florida College of Medicine, Gainesville, Florida.

Melanocyte development is orchestrated by a complex interconnecting regulatory network of genes and synergistic interactions. Piebaldism and Waardenburg syndrome are neurocristopathies that arise from mutations in genes involved in this complex network. Our understanding of melanocyte development, Piebaldism, and Waardenburg syndrome has improved dramatically over the past decade. Read More

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http://dx.doi.org/10.1111/pde.13713DOI Listing
January 2019

A case report: Co-occurrence of Wilson disease and oculocutaneous albinism in a Chinese patient.

Medicine (Baltimore) 2018 Dec;97(50):e13744

The Affiliated Hospital of the Neurology Institute of Anhui University of Chinese Medicine, Hefei, Anhui, China.

Rationale: Both Wilson disease (WD) and Oculocutaneous Albinism (OCA) are rare autosomal recessive disorders that are caused by mutations on chromosome 13 and chromosome 11, respectively. Here, we report on a patient with coexisting WD and OCA, initially presenting episodes of tremors.

Patient Concerns: WD is a disorder of copper metabolism. Read More

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http://dx.doi.org/10.1097/MD.0000000000013744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320091PMC
December 2018
2 Reads

KIT as a therapeutic target for non-oncological diseases.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-HM, Marseille, France. Electronic address:

KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01637258183023
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http://dx.doi.org/10.1016/j.pharmthera.2018.12.008DOI Listing
December 2018
7 Reads

Dermoscopic pre- and posttreatment evaluation in patients with androgenetic alopecia on platelet-rich plasma-A prospective study.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Dermatology, Venereology and Leprosy, A. J. Institute of Medical Sciences, Mangalore, India.

Background: Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders.

Objectives: To evaluate and study the role of dermoscopy in patients with androgenetic alopecia (AGA) pre- and posttreatment with platelet-rich plasma (PRP). Read More

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http://dx.doi.org/10.1111/jocd.12845DOI Listing
December 2018
2 Reads

Identification of a novel mutation in X-linked ocular albinism with marked intrafamilial phenotypic variability.

J Genet 2018 12;97(5):1479-1484

Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea.

Ocular albinism type 1 (OA1) is an X-linked inherited disease characterized by impaired visual acuity, congenital nystagmus, foveal hypoplasia, hypopigmentation of iris and fundus. It is caused by mutations in the G protein-coupled receptor143 () gene. The genetic characteristics of OA1 have not been well defined in Asians. Read More

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December 2018
4 Reads

MIG Th1 chemokine in Vitiligo.

Authors:
G Elia

Clin Ter 2018 Nov-Dec;169(6):e303-e307

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The importance of the Type-1 helper immune response in the development of Vitiligo (Vit), and of chemokine receptor (CXCR)3 receptor and its chemokine monokine induced by interferon (IFN)-γ(MIG) has been shown by several studies. MIG/ interferon (IFN)-γ-inducible protein 10 (IP10) /CXCR3 axis mediated T-cell recruitment into the skin in Vit is an early event in the progression of the disease. MIG and IP10 circulating levels are increased in progressive Vit. Read More

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http://dx.doi.org/10.7417/CT.2018.2098DOI Listing
January 2019
6 Reads

Transverse melanonychia in a child receiving chemotherapy.

Pediatr Dermatol 2019 Jan 12;36(1):e60-e61. Epub 2018 Dec 12.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Transverse melanonychia is a rare finding often secondary to chemotherapy, orally ingested medications, or other iatrogenic interventions. A 19-month-old boy with hemophagocytic lymphohistiocytosis treated with biweekly etoposide and dexamethasone developed transverse bands of pigment in all toenail and fingernail units consistent with transverse melanonychia. We review the literature for reported cases of transverse melanonychia and summarize suspected etiologies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13721
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http://dx.doi.org/10.1111/pde.13721DOI Listing
January 2019
9 Reads
1.520 Impact Factor

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310574PMC
December 2018
5 Reads

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate and keep quiescence to control and coordinate tissue homeostasis, repair and regeneration. Read More

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http://dx.doi.org/10.1111/exd.13856DOI Listing
December 2018
14 Reads

The different roles of 5-HT1A/2A receptors in fluoxetine ameliorated pigmentation of C57BL/6 mouse skin in response to stress.

J Dermatol Sci 2018 Dec 25;92(3):222-229. Epub 2018 Oct 25.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Background: 5-HT1A receptor was participated in fluoxetine induced melanogenesis in melanocytes and in normal C57BL/6 mice, but we know little about whether other 5-HT receptors are involved in regulation of fluoxetine promotes pigmentation.

Objective: To investigate the role of 5-HT receptors in regulation of fluoxetine ameliorates chronic unpredictable mild stress (CUMS) and chronic restraint stress (CRS) induce hypopigmentation in C57BL/6 mice.

Methods: CUMS and CRS were used to induce depigmentation in mice and evaluate the effect of fluoxetine. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.002DOI Listing
December 2018
1 Read

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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http://dx.doi.org/10.1111/hdi.12689DOI Listing
December 2018
4 Reads

The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients.

Pediatr Dermatol 2019 Jan 5;36(1):e53-e55. Epub 2018 Dec 5.

Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. Read More

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http://dx.doi.org/10.1111/pde.13726DOI Listing
January 2019
4 Reads

Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation.

Biol Res 2018 Nov 29;51(1):54. Epub 2018 Nov 29.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulatory effects of sericin have been known for decades. However, the therapeutic effects of sericin on hyperpigmentation disorders have not been well documented. Read More

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http://dx.doi.org/10.1186/s40659-018-0204-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262948PMC
November 2018
9 Reads

Evaluation of skin expression profiles of patients with vitiligo treated with narrow-band UVB therapy by targeted RNA-seq.

An Bras Dermatol 2018 Nov/Dec;93(6):843-851

Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.

Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment.

Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256230PMC
February 2019
7 Reads

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model.

Dev Dyn 2019 Feb 18;248(2):153-161. Epub 2018 Dec 18.

Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbors many favorable constructive traits (i. Read More

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http://doi.wiley.com/10.1002/dvdy.4
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http://dx.doi.org/10.1002/dvdy.4DOI Listing
February 2019
9 Reads

Possible hints and pitfalls in diagnosing Peutz-Jeghers syndrome.

J Pediatr Endocrinol Metab 2018 Dec;31(12):1381-1386

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Background Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal polyposis, mucocutaneous pigmentation and cancer predisposition. Patients with PJS can develop large calcifying Sertoli cell tumors (LCSTs). Case presentation A patient presented at 3 years of age with delayed development, hypermobility and later also with tall stature and advanced bone age. Read More

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http://www.degruyter.com/view/j/jpem.ahead-of-print/jpem-201
Publisher Site
http://dx.doi.org/10.1515/jpem-2018-0265DOI Listing
December 2018
13 Reads

The Inhibition of Melanogenesis Via the PKA and ERK Signaling Pathways by Extract in B16F10 Melanoma Cells and Artificial Human Skin Equivalents.

J Microbiol Biotechnol 2018 Dec;28(12):2121-2132

Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul 05029, Republic of Korea.

Abnormal melanin synthesis results in several hyperpigmentary disorders such as freckles, melanoderma, age spots, and other related conditions. In this study, we investigated the antimelanogenic effects of an extract from the microalgae (CE) and potential mechanisms responsible for its inhibitory effect in B16F10, normal human epidermal melanocyte cells, and human skin-equivalent models. The CE extract showed significant dose-dependent inhibitory effects on α-melanocyte-stimulating, hormone-induced melanin synthesis in cells. Read More

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http://dx.doi.org/10.4014/jmb.1810.10008DOI Listing
December 2018
8 Reads

Sub-lethal effects induced by a mixture of different pharmaceutical drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw, 1802) (Anura, ranidae) tadpoles.

Environ Sci Pollut Res Int 2019 Jan 8;26(1):600-616. Epub 2018 Nov 8.

Post-Graduation Program in Conservation of Cerrado Natural Resources - Biological Research Laboratory, Goiano Federal Institute-Urutaí Campus, Urutaí, GO, Brazil.

The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a "drug mix" (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of different medication classes (antibiotic, anti-inflammatory, antidepressant, anxiolytic, analgesic, and antacid drugs)-at environmentally relevant concentrations-may change their oral morphology, trigger behavioral disorders, and have mutagenic effects on erythrocyte cells. Read More

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http://link.springer.com/10.1007/s11356-018-3656-9
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http://dx.doi.org/10.1007/s11356-018-3656-9DOI Listing
January 2019
13 Reads

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment.

Int J Nanomedicine 2018 15;13:6465-6479. Epub 2018 Oct 15.

Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia,

Introduction: Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation. In this study, KMO was formulated in an oil-in-water nanoemulsion as a carrier for better penetration into the skin.

Methods: The nanoemulsion was prepared by using high and low energy emulsification technique. Read More

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http://dx.doi.org/10.2147/IJN.S171532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198893PMC
December 2018
8 Reads

Stimulation of melanin synthesis in melanoma cells by cold plasma.

Biol Chem 2018 Dec;400(1):101-109

Department Plasma Life Science, Leibniz-Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, D-17489 Greifswald, Germany.

Skin color is derived from epidermal melanocytes that contain specialized organelles in which melanin is formed. The formation of melanin is a well-orchestrated process, and reactive oxygen species (ROS) play a role in numerous enzymatic conversions, such as the reactions catalyzed by tyrosinase and tyrosine hydroxylase. Currently, there is ample evidence that cold plasma exerts biological effects on cells through the impact of ROS and reactive nitrogen species (RNS). Read More

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http://www.degruyter.com/view/j/bchm.ahead-of-print/hsz-2018
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http://dx.doi.org/10.1515/hsz-2018-0223DOI Listing
December 2018
20 Reads

[Cervico-occipital junction malformation and vitiligo].

Pan Afr Med J 2018 20;30:146. Epub 2018 Jun 20.

Departement of Dermatology, Military Hospital My Ismail, Meknes, Morocco.

Vitiligo is a relatively common multifactorial polygenetic dermatosis (0.5%-2% of general population) characterized by segmental or nonsegmental cutaneous depigmentation. Chiari malformation is a congenital cervico-occipital junction disease characterized by a migration of a part of the cerebellum through the foramen magnum. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.146.15610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201618PMC
November 2018
5 Reads

Otological surgery in paediatric photosensitive patients.

Int J Pediatr Otorhinolaryngol 2018 Dec 15;115:175-176. Epub 2018 Sep 15.

Great Ormond Street Hospital, London, UK.

There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183045
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http://dx.doi.org/10.1016/j.ijporl.2018.09.001DOI Listing
December 2018
12 Reads

Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.

Bioorg Med Chem 2018 Nov 19;26(21):5672-5681. Epub 2018 Oct 19.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, South Korea. Electronic address:

Pigmentation disorders are attributed to excessive melanin which can be produced by tyrosinase. Therefore, tyrosinase is supposed to be a vital target for the treatment of disorders associated with overpigmentation. Based on our previous findings that an (E)-β-phenyl-α,β-unsaturated carbonyl scaffold can play a key role in the inhibition of tyrosinase activity, and the fact that cinnamic acid is a safe natural substance with a scaffolded structure, it was speculated that appropriate cinnamic acid derivatives may exhibit potent tyrosinase inhibitory activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183146
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http://dx.doi.org/10.1016/j.bmc.2018.10.014DOI Listing
November 2018
14 Reads

Treatment of Moderate Acne Vulgaris in Fitzpatrick Skin Type V or VI: Efficacy and Tolerability of Fixed Combination Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% Gel.

J Drugs Dermatol 2018 Oct;17(10):1107-1112

Background: Acne vulgaris (acne) is the most common skin disease in patients who have darker skin with most frequent sequelae of post inflammatory hyperpigmentation (PIH).

Methods: Open label study in 20 patients (mean age 32 years) with Fitzpatrick Skin Type V or VI and with moderate facial acne treated with clindamycin phosphate 1.2%/benzoyl peroxide 3. Read More

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October 2018
11 Reads

Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians.

Lasers Surg Med 2019 Jan 25;51(1):14-22. Epub 2018 Oct 25.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background And Objectives: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars. Read More

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http://doi.wiley.com/10.1002/lsm.23028
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http://dx.doi.org/10.1002/lsm.23028DOI Listing
January 2019
26 Reads

Differential corneal involvement in xeroderma pigmentosum.

Authors:
Sunita Chaurasia

Indian J Ophthalmol 2018 Nov;66(11):1623

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_667_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213660PMC
November 2018

Corneal edema in xeroderma pigmentosa.

Authors:
Sunita Chaurasia

Indian J Ophthalmol 2018 Nov;66(11):1622

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_469_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213657PMC
November 2018

Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.

Eur J Med Chem 2019 Jan 15;161:78-92. Epub 2018 Oct 15.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, 46241, South Korea. Electronic address:

Of the three enzymes that regulate the biosynthesis of melanin, tyrosinase and its related proteins TYRP-1 and TYRP-2, tyrosinase is the most important because of its ability to limit the rate of melanin production in melanocytes. For treating skin pigmentation disorders caused by an excess of melanin, the inhibition of tyrosinase enzyme is by far the most established strategy. Cinnamic acid is a safe natural product with an (E)-β-phenyl-α,β-unsaturated carbonyl motif that we have previously shown to play an important role in high tyrosinase inhibition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183088
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http://dx.doi.org/10.1016/j.ejmech.2018.10.025DOI Listing
January 2019
14 Reads

[Scleroatrophic extragenital lichen and inflammatory vitiligo in children: a rare association].

Pan Afr Med J 2018 29;30:75. Epub 2018 May 29.

Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN SINA, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions evolving over 6 months. Read More

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http://www.panafrican-med-journal.com/content/article/30/75/
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http://dx.doi.org/10.11604/pamj.2018.30.75.13954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191275PMC
October 2018
9 Reads

Identification of a Homozygous Missense Mutation in the TYR Gene in a Chinese Family with OCA1.

Curr Med Sci 2018 Oct 20;38(5):932-936. Epub 2018 Oct 20.

Department of Laboratory Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China.

Oculocutaneous albinism (OCA) is an autosomal recessive pigmentation abnormality, characterized by variable hair, skin, and ocular hypopigmentation. OCA1 is the most frequent subtype of OCA, caused by mutations in the tyrosinase gene (TYR). In this study, we investigated the genetic mutation of a Chinese family with a female OCA patient who came for genetic counseling before pregnancy. Read More

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http://dx.doi.org/10.1007/s11596-018-1965-3DOI Listing
October 2018
1 Read