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    1 OF 684

    An unusual presentation of primary cutaneous amyloidosis.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.
    Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. Read More

    Natural options for management of melasma, a review.
    J Cosmet Laser Ther 2018 Feb 20:1-12. Epub 2018 Feb 20.
    a Laser Research Centre, Faculty of Health Sciences , University of Johannesburg , Doornfontein , South Africa.
    A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. Read More

    Coumestrol Confers Partial Resistance in Soybean Plants Against Cercospora Leaf Blight.
    Phytopathology 2018 Feb 16. Epub 2018 Feb 16.
    Louisiana State Univ, Plant Pathology , 302 Life Sciences Bldg , Baton Rouge, Louisiana, United States , 70803 ;
    Although previous research showed that the purple symptom of Cercospora leaf blight (CLB) is associated with lower biomass of Cercospora cf. flagellaris and lower concentrations of cercosporin, a reactive oxygen species producer, as compared to blighted leaves, the hypothesis that the purple symptom is a plant reaction to the pathogen has never been tested. In this study, we demonstrated that high levels of coumestrol (COU) were associated with purple symptoms of CLB and that COU has strong antioxidant activity. Read More

    Mucocutaneous Manifestations in Patients with Chronic Kidney Disease: A Cross-sectional Study.
    Indian Dermatol Online J 2018 Jan-Feb;9(1):20-26
    Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Himachal Pradesh, India.
    Background: Chronic kidney disease (CKD)-associated mucocutaneous manifestations significantly impair the quality of life but often remain understudied. They may also vary across regions, socioeconomic and nutritional status, and racial differences.

    Objectives: To study the patterns of mucocutaneous disorders and their prevalence in CKD patients irrespective of clinical stage or dialysis status. Read More

    TRP‑2 mediates coat color pigmentation in sheep skin.
    Mol Med Rep 2018 Feb 6. Epub 2018 Feb 6.
    College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi 030801, P.R. China.
    Tyrosinase‑related protein 2 (TRP‑2) is one of the most important members of the tyrosinase family, and is a key enzyme involved in melanin biosynthesis. In the present study, a skin transcriptome profile, immunohistochemistry, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to investigate TRP‑2 expression in sheep with different coat colors, namely, black, white and black‑white. TRP‑2 was overexpressed in melanocytes in order to study the effect of TRP‑2 on melanin production. Read More

    Dietary intake of glucono-δ-lactone attenuates skin inflammation and contributes to maintaining skin condition.
    Food Funct 2018 Feb 12. Epub 2018 Feb 12.
    Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.
    Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e. Read More

    Pigmentation Disorders: Diagnosis and Management.
    Am Fam Physician 2017 Dec;96(12):797-804
    Norton Audobon Hospital, Louisville, KY, USA.
    Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

    Health Survey of Adults with Neurofibromatosis 1 Compared to Population Study Controls.
    J Genet Couns 2018 Feb 10. Epub 2018 Feb 10.
    Frambu Resource Centre for Rare Disorders, Sandbakkvn 18, Siggerud, Norway.
    Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies have shown impaired health-related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non-clinical NF1 samples. Read More

    Cerebellar ataxia-dominant phenotype in patients with ERCC4 mutations.
    J Hum Genet 2018 Feb 5. Epub 2018 Feb 5.
    Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Autosomal recessive cerebellar ataxias (ARCAs) are clinically and genetically heterogeneous neurological disorders. Through whole-exome sequencing of Japanese ARCA patients, we identified three index patients from unrelated families who had biallelic mutations in ERCC4. ERCC4 mutations have been known to cause xeroderma pigmentosum complementation group F (XP-F), Cockayne syndrome, and Fanconi anemia phenotypes. Read More

    Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin.
    Eur J Cell Biol 2018 Jan 26. Epub 2018 Jan 26.
    Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil; Department of Biology, University of Virginia, Charlottesville, VA, USA. Electronic address:
    The mammalian skin has a photosensitive system comprised by several opsins, including rhodopsin (OPN2) and melanopsin (OPN4). Recently, our group showed that UVA (4.4 kJ/m) leads to immediate pigment darkening (IPD) in murine normal and malignant melanocytes. Read More

    Influence of Visible Light on Cutaneous Hyperchromias: Clinical Efficacy of Broad Spectrum Sunscreens.
    Photodermatol Photoimmunol Photomed 2018 Jan 30. Epub 2018 Jan 30.
    Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo.
    Introduction: Cutaneous hyperchromias are disorders of skin pigmentation involving increased melanin production and its irregular accumulation in skin cells. The use of sunscreens is fundamental for the control of hyperchromias by reducing the stimulation of pigmentation, since melanin synthesis is mainly stimulated by solar radiation. Many studies have demonstrated that visible light can induce significant skin damage. Read More

    Xeroderma Pigmentosum - Facts and Perspectives.
    Anticancer Res 2018 02;38(2):1159-1164
    Clinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany
    Ultraviolet (UV)-induced DNA lesions are almost exclusively removed by the nucleotide excision repair (NER) pathway, which is essential for prevention of skin cancer development. Patients with xeroderma pigmentosum (XP) are extremely sun sensitive due to a genetic defect in components of the NER cascade. They present with first signs of premature skin aging at an early age, with a considerably increased risk of developing UV-induced skin cancer. Read More

    Upregulation ofby Phenolic Compounds-RichTreatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes.
    Biomed Res Int 2017 21;2017:8303671. Epub 2017 Nov 21.
    Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba City 305-8572, Japan.
    Melanin provides inherent protection against skin cancer by absorbing broad-spectrum radiant energy of UV radiation. Cutaneous malignant melanoma incidence has recently been observed to increase and the frequency is closely associated with the skin color, highlighting the importance of skin pigmentation. Here, we showed how melanin biosynthesis is enhanced by treatment with phenolic compounds-rich(CYM) in B16 murine melanoma cells and human epidermal melanocytes (HEM). Read More

    Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin.
    Br J Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.
    Vitiligo is the most common pigmentation disorder, with a worldwide prevalence of 1%. The loss of melanocytes from the skin is the main clinical feature of patients with vitiligo, resulting in depigmentation macules. Vitiligo has been classified into two major forms: non-segmental vitiligo (NSV) and segmental vitiligo (SV). Read More

    Actual state of knowledge in the field of diseases related with defective nucleotide excision repair.
    Life Sci 2018 Feb 2;195:6-18. Epub 2018 Jan 2.
    Food Science Department, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
    Xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome (CS) are rare genetic diseases characterized by a large range of clinical symptoms. However, they are all associated with defects in nucleotide excision repair (NER), the system responsible for removing bulky DNA lesions such as those generated by UV light: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone photoproducts (6-4 PPs). Over the past years, detailed structural and biochemical information on NER-associated proteins has emerged. Read More

    Oral mucosa lesions and gingival bleeding can indicate the progression of liver disease in children and adolescents aged two to 18 years.
    Acta Paediatr 2018 Jan 3. Epub 2018 Jan 3.
    Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children's Memorial Health Institute, Warsaw, Poland.
    Aim: This study assessed correlations between systemic disturbances of paediatric chronic liver diseases (CLD) and oral symptoms in subjects aged 2-18 years.

    Methods: It was carried out during outpatient appointments at the Children's Memorial Health Institute, Warsaw, Poland, from 2010 to 2015 and comprised 52 CLD patients with a mean age of 12.3 ± 4. Read More

    Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients.
    J Photochem Photobiol B 2018 Jan 6;178:577-583. Epub 2017 Dec 6.
    Department of Dermato-venerology, Bispebjerg University Hospital, 2400 Copenhagen, Denmark.
    Importance: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.

    Objectives: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines. Read More

    A Novel Generalized Lipodystrophy-associated Progeroid Syndrome due to recurrent heterozygous LMNA p.T10I Mutation.
    J Clin Endocrinol Metab 2017 Dec 15. Epub 2017 Dec 15.
    Center for Human Nutrition, Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
    Background: Lamin A/C (LMNA) gene mutations cause a heterogeneous group of progeroid disorders including Hutchinson-Gilford progeria syndrome (HGPS), mandibuloacral dysplasia, and atypical progeroid syndrome (APS). Five of the 31 previously reported APS patients harbored a recurrent de novo heterozygous LMNA p.T10I mutation. Read More

    Congenital longitudinal melanonychia: a case report.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):119-120
    Department of Dermatology, University Medical Centre, Maribor, Slovenia.
    Congenital longitudinal melanonychia is rarely seen in Caucasians and poses a diagnostic dilemma. It is characterized by the presence of hyperpigmented brown or black streaks visible in the nail plate. We present the case of 20-month-old boy with congenital longitudinal melanonychia, the diagnostic procedure, and management. Read More

    Deletion 21pterq22.11: Report of a Patient with Dysmorphic Features, Hypertonia, and Café-au-Lait Macules and Review of the Literature.
    Cytogenet Genome Res 2017 20;153(2):81-85. Epub 2017 Dec 20.
    Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.
    Partial monosomy 21 results in a great variability of clinical features that may be associated with the size and location of the deletion. In this study, we report a 22-month-old girl who showed a 45,XX,add(12)(p13)dn,-21 karyotype. The final cytogenomic result was 45,XX,der(12)t(12;21)(p13;q22. Read More

    Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function.
    Ophthalmic Surg Lasers Imaging Retina 2017 Dec;48(12):1016-1020
    The authors report the first case, to their knowledge, of failed pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD) repair in a patient with ocular albinism (OA). The failure of PR to spontaneously resolve the subretinal fluid and reattach the retina in this case is suggestive of a deficiency in subretinal fluid reabsorption by the retinal pigment epithelium (RPE). These findings suggest that in cases of RRD in OA, primary PR should be avoided since this procedure relies on an adequately functioning RPE pump to reabsorb subretinal fluid prior to laser retinopexy. Read More

    Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature.
    Am J Case Rep 2017 Dec 18;18:1347-1350. Epub 2017 Dec 18.
    Department of Hematology/Oncology, Cleveland Clinic Florida, Maroone Cancer Center, Weston, FL, USA.
    BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Read More

    A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8591
    aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. Read More

    A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8466
    aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
    Rationale: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.

    Patient Concerns: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. Read More

    Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets.
    J Pathol 2018 Mar 5;244(3):358-366. Epub 2018 Feb 5.
    Bio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, PR China.
    Oral mucosal melanoma (OMM) is a rare and aggressive subtype of melanoma with little known about its pathogenesis or carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers of tumor formation. For the first time, we describe the comprehensive mutational profile of OMM. Read More

    In vivo toxic effects of 4-methoxy-5-hydroxy-canthin-6-one in zebrafish embryos via copper dyshomeostasis and oxidative stress.
    Comp Biochem Physiol C Toxicol Pharmacol 2018 Jan 5;204:79-87. Epub 2017 Dec 5.
    State Key Laboratory of Innovative Natural Medicines and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, Jiangxi, China.
    Dysfunction of copper homeostasis can lead to a host of disorders, which might be toxic sometimes. 4-Methoxy-5-hydroxy-canthin-6-one (CAN) is one of the major constituents from Picrasma quassioides and responsible for its therapeutic effects. In this work, we evaluated the toxic effect of CAN (7. Read More

    Clinical and Genetic Review of Hereditary Acral Reticulate Pigmentary Disorders.
    Dermatol Res Pract 2017 23;2017:3518568. Epub 2017 Oct 23.
    Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired disorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content. This review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica hereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura. Read More

    Homeopathic Treatment of Vitiligo: A Report of Fourteen Cases.
    Am J Case Rep 2017 Dec 2;18:1276-1283. Epub 2017 Dec 2.
    International Academy of Classical Homeopathy, Alonissos, Greece.
    BACKGROUND Vitiligo, also known as leukoderma, is an autoimmune skin condition that results in the loss of melanin pigment. Vitiligo is not a rare condition but is difficult to treat and is associated with psychological distress. CASE REPORT A series of 14 cases of vitiligo are presented that were treated with individualized homeopathic remedies that were based on plant, animal, or mineral compounds. Read More

    Familial progressive hyper- and hypopigmentation: a report on a Chinese family and evidence for genetic heterogeneity.
    An Bras Dermatol 2017 May-Jun;92(3):329-333
    Department of Dermatology, Qilu Hospital of Shandong University - Jinan, Shandong Sheng, China.
    Background: Familial progressive hyper- and hypopigmentation (FPHH) is a rare genodermatosis that is characterized by diffuse hyper- and hypopigmented spots on the skin and mucous membranes. It is caused by a pathogenic mutation of the KITLG gene.

    Objectives: To investigate the clinical features and mutation of the KITLG gene in a Chinese family with FPHH. Read More

    Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo.
    An Bras Dermatol 2017 May-Jun;92(3):312-318
    Private clinic - Belo Horizonte (MG), Brazil.
    Background: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases.

    Objectives: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. Read More

    [Common variable immune deficiency lately revealed by gastrointestinal problems: about a case].
    Pan Afr Med J 2017 20;28:48. Epub 2017 Sep 20.
    Service d'Hépato-Gastro-Entérologie, CHU Ibn Rochd, Casablanca, Maroc.
    Common Variable Immune Deficiency (CVID) is rare. It is a constitutional deficit of humoral immunity characterized by recurrent bacterial infections and by increased frequency of tumors, autoimmune or granulomatous diseases. Gastrointestinal manifestations are very variable and sometimes reveal common variable immune deficiency. Read More

    Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
    BMC Med Genet 2017 11 15;18(1):130. Epub 2017 Nov 15.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd, Shanghai, 200433, China.
    Background: Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer.

    Case Presentation: We reported an isolated PJS patient who died of colon cancer, whose blood sample was collected together with all the available family members'. The entire coding region of the STK11 gene was amplified by PCR and analyzed by Sanger sequencing, through which, a novel mutation, c. Read More

    Methoxsalen-induced macular toxicity.
    Indian J Ophthalmol 2017 Nov;65(11):1243-1245
    Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as psoriasis and vitiligo. Methoxsalen has been shown to be associated with premature cataract formation by forming adducts with lens proteins following oral administration and subsequent UVA exposure. Hence, the use of UV-filtering glasses is recommended during PUVA therapy sessions. Read More

    Latanoprost-induced Skin Depigmentation.
    J Glaucoma 2017 Nov;26(11):e246-e248
    Department of Ophthalmology, University of California Irvine School of Medicine.
    Latanoprost, and other prostaglandin analogs, have been previously associated with increased pigmentary reactions on the periocular skin. Here, we present a patient with paradoxical depigmentation of periocular skin within 1 year of latanoprost use in both eyes. This report is the first to document such an association, and clinicians should be aware of this adverse effect and monitor for signs accordingly. Read More

    Odorants could elicit repair processes in melanized neuronal and skin cells.
    Neural Regen Res 2017 Sep;12(9):1401-1404
    Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
    The expression of ectopic olfactory receptors (ORs) in melanized cells, such as the human brain nigrostriatal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson's disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through α-synuclein expression is also highlighted. Read More

    Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases.
    PLoS One 2017 31;12(10):e0186668. Epub 2017 Oct 31.
    Department of Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
    Backgrounds And Aims: The association of melanosis coli with the development of colorectal polyps remains uncertain.

    Methods: From a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neoplasm with grades and distribution of melanosis coli were analyzed. Read More

    Restoration of skin pigmentation after deep partial or full-thickness burn injury.
    Adv Drug Deliv Rev 2018 Jan 24;123:155-164. Epub 2017 Oct 24.
    Burns and Reconstructive Surgery Unit, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia.
    Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. Read More

    Evaluation of the anterior chamber angle in pseudoexfoliation syndrome.
    Adv Clin Exp Med 2017 Aug;26(5):795-801
    Department and Clinic of Ophthalmology, Wroclaw Medical University, Poland.
    Background: Pseudoexfoliation syndrome (PEX) is the most frequently identifiable cause of secondary open-angle glaucoma, known as pseudoexfoliation glaucoma. The exact pathophysiology and etiology of PEX and associated glaucoma remains obscure.

    Objectives: The purpose of this study was to determine the differences in the morphology of the anterior chamber angle in people with pseudoexfoliation syndrome and pseudoexfoliation glaucoma compared to a control group. Read More

    Considerations When Treating Cosmetic Concerns in Men of Color.
    Dermatol Surg 2017 Nov;43 Suppl 2:S140-S150
    *Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC; †Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC; ‡Department of Dermatology, Georgetown University School of Medicine, Washington, DC; §Division of Dermatology, University of California, Los Angeles, California.
    Background: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population.

    Objective: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. Read More

    The importance of genetic testing as demonstrated by two cases of-associated retinal generation misdiagnosed as LCA.
    Mol Vis 2017 10;23:695-706. Epub 2017 Oct 10.
    Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
    Purpose: To describe in detail cases with an initial diagnosis of Leber congenital amaurosis that were later found to have a hemizygous mutation in thegene.

    Methods: The patients underwent a detailed ophthalmological evaluation and full-field electroretinography (ERG). Selective targeted capture and whole-exome next-generation sequencing (NGS) were used to find the disease-causing mutations. Read More

    Defining the actinic keratosis field: a literature review and discussion.
    J Eur Acad Dermatol Venereol 2017 Oct 21. Epub 2017 Oct 21.
    Dermatology Unit, Virgen Macarena University Hospital, Seville, Spain.
    Despite the chronic and increasingly prevalent nature of actinic keratosis (AK) and existing evidence supporting assessment of the entire cancerization field during clinical management, a standardized definition of the AK field to aid in the understanding and characterization of the disease is lacking. The objective of this review was to present and appraise the available evidence describing the AK cancerization field, with the aim of determining a precise definition of the AK field in terms of its molecular (including genetic and immunological), histological and clinical characteristics. Eight European dermatologists collaborated to conduct a review and expert appraisal of articles detailing the characteristics of the AK field. Read More

    Effects of a non-cyclodextrin cyclic carbohydrate on mouse melanoma cells: Characterization of a new type of hypopigmenting sugar.
    PLoS One 2017 18;12(10):e0186640. Epub 2017 Oct 18.
    R&D Center, Hayashibara Co., Ltd., Okayama, Japan.
    Cyclic nigerosyl nigerose (CNN) is a cyclic tetrasaccharide that exhibits properties distinct from other conventional cyclodextrins. Herein, we demonstrate that treatment of B16 melanoma with CNN results in a dose-dependent decrease in melanin synthesis, even under conditions that stimulate melanin synthesis, without significant cytotoxity. The effects of CNN were prolonged for more than 27 days, and were gradually reversed following removal of CNN. Read More

    Morphologic and Elemental Analysis of Primary Melanosis of the Dentate Nucleus: Review and Correlation With Neuromelanin.
    J Neuropathol Exp Neurol 2017 Nov;76(11):949-956
    Department of Pathology, School of Medicine, University of South Florida-Morsani, Tampa, Florida; Medical College of Georgia, Augusta University, Augusta, Georgia.
    Primary melanosis of the dentate nucleus is a rarely described entity with neither known cause nor definitive clinicopathologic correlation. We revisit this previously reported phenomenon by presenting one such case with a review of the pathology as well as additional investigations including elemental analysis by energy-dispersive X-ray, immunohistochemistry and electron microscopy. The lesion presented macroscopically as a sharply defined, black pigmentation that was restricted to the dentate nucleus of the cerebellum. Read More

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