34,472 results match your criteria Hypomelanosis of Ito


Non-plaque-induced gingival diseases.

J Periodontol 2018 Jun;89 Suppl 1:S28-S45

Department of Periodontology, University of Giessen, Giessen, Germany.

While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation. Read More

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June 2018
2 Reads

Non-plaque-induced gingival diseases.

J Clin Periodontol 2018 Jun;45 Suppl 20:S28-S43

Department of Periodontology, University of Giessen, Giessen, Germany.

While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation. Read More

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June 2018
1 Read

Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo.

Clin Exp Dermatol 2018 Jun 20. Epub 2018 Jun 20.

Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.

Background: Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders.

Aim: To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegmental vitiligo. Read More

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June 2018
1 Read

Analysis of genotype/phenotype correlations in Japanese patients with dyschromatosis symmetrica hereditaria.

Nagoya J Med Sci 2018 May;80(2):267-277

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Dyschromatosis symmetrica hereditaria (DSH) is one of the genetic pigmentation disorders and shows characteristic mixture of hyper- and hypo-pigmented small macules on the extremities. Heterozygous mutations in the adenosine deaminase acting on RNA1 gene () cause DSH. In the present study, we report five cases of DSH and identify a distinct known mutation in each patient. Read More

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May 2018
2 Reads

Classification of non-tumorous skin pigmentation disorders using voting based probabilistic linear discriminant analysis.

Comput Biol Med 2018 Jun 5;99:123-132. Epub 2018 Jun 5.

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore. Electronic address:

Non-tumorous skin pigmentation disorders can have a huge negative emotional impact on patients. The correct diagnosis of these disorders is essential for proper treatments to be instituted. In this paper, we present a computerized method for classifying five non-tumorous skin pigmentation disorders (i. Read More

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Traditional and ethnobotanical dermatology practices in Africa.

Clin Dermatol 2018 May - Jun;36(3):353-362. Epub 2018 Mar 10.

Department of Chemistry, Dedan Kimathi University of Technology, Nyeri, Kenya.

More than 80% of the global population depends on traditional medicine for their basic primary health care needs. Africa has a well-established history of botanicals use. These include a vast array of compounds that can be used to treat various skin-related conditions. Read More

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Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes.

Sci Rep 2018 Jun 14;8(1):9112. Epub 2018 Jun 14.

CECS, I-Stem, Corbeil-Essonnes, 91100, France.

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that leads to premature aging. In this study, we used induced pluripotent stem cells to investigate the hypopigmentation phenotypes observed in patients with progeria. Accordingly, two iPS cell lines were derived from cells from HGPS patients and differentiated into melanocytes. Read More

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Macrophage activation syndrome associated with griscelli syndrome type 2: case report and review of literature.

Pan Afr Med J 2018 25;29:75. Epub 2018 Jan 25.

Center for Hematology and Oncology Paediatrics, Children's hospital, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.

Macrophage activation syndrome (MAS) is a severe and potentially fatal life-threatening condition associated with excessive activation and expansion of T cells with macrophages and a high expression of cytokines, resulting in an uncontrolled inflammatory response, with high levels of macrophage colony-stimulating factor and causing multiorgan damage. This syndrome is classified into primary (genetic/familial) or secondary forms to several etiologies, such as infections, neoplasias mainly hemopathies or autoimmune diseases. It is characterised clinically by unremitting high fever, pancytopaenia, hepatosplenomegaly, hepatic dysfunction, encephalopathy, coagulation abnormalities and sharply increased levels of ferritin. Read More

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June 2018
3 Reads

Bimatoprost in Dermatology.

Indian Dermatol Online J 2018 May-Jun;9(3):224-228

Department of Skin and V.D, Patna Medical College and Hospital, Patna, Bihar, India.

Bimatoprost is a prostamide analogue used for treatment of glaucoma in ophthalmology. Surprisingly, the side effects such as increased pigmentation of eyelids and hypertrichosis in patients being treated with prostaglandin analogues for glaucoma have opened new areas of application in various dermatological disorders such as alopecia mainly affecting eyelashes, eyebrows, and vitiligo. Read More

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Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male.

Ann Dermatol 2018 Jun 23;30(3):342-344. Epub 2018 Apr 23.

Department of Dermatology, Ewha Womans University School of Medicine, Seoul, Korea.

Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history of hypertension and had never taken angiotensin converting enzyme inhibitors. Read More

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June 2018
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Decreased choroidal thickness in vitiligo patients.

BMC Ophthalmol 2018 May 29;18(1):126. Epub 2018 May 29.

Department of Dermatology and Venerology, Kirikkale University Faculty of Medicine, Yenisehir District, Tahsin Duru Avenue, No:14, Yahsihan, Kirikkale, Turkey.

Background: Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness of patients with and without vitiligo using optical coherence tomography (OCT). Read More

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Effect of Fixed Metallic Oral Appliances on Oral Health.

Authors:
Ahmad Alnazzawi

J Int Soc Prev Community Dent 2018 Mar-Apr;8(2):93-98. Epub 2018 Apr 24.

Department of Substitutive Dental Sciences, College of Dentistry, Taibah University Madinah, KSA.

There is a substantial proportion of the population using fixed metallic oral appliances, such as crowns and bridges, which are composed of various dental alloys. These restorations may be associated with a number of effects on oral health with variable degrees of severity, to review potential effects of using fixed metallic oral appliances, fabricated from various alloys. The MEDLINE/PubMed database was searched using certain combinations of keywords related to the topic. Read More

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Beginning at the ends: telomeres and human disease.

Authors:
Sharon A Savage

F1000Res 2018 1;7. Epub 2018 May 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Studies of rare and common illnesses have led to remarkable progress in the understanding of the role of telomeres (nucleoprotein complexes at chromosome ends essential for chromosomal integrity) in human disease. Telomere biology disorders encompass a growing spectrum of conditions caused by rare pathogenic germline variants in genes encoding essential aspects of telomere function. Dyskeratosis congenita, a disorder at the severe end of this spectrum, typically presents in childhood with the classic triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia, accompanied by a very high risk of bone marrow failure, cancer, pulmonary fibrosis, and other medical problems. Read More

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Heterozygous missense variants of LMX1A lead to nonsyndromic hearing impairment and vestibular dysfunction.

Hum Genet 2018 May 12. Epub 2018 May 12.

Department of Otorhinolaryngology, Hearing and Genes, Radboud University Medical Center, Internal Postal Code 377, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Unraveling the causes and pathomechanisms of progressive disorders is essential for the development of therapeutic strategies. Here, we identified heterozygous pathogenic missense variants of LMX1A in two families of Dutch origin with progressive nonsyndromic hearing impairment (HI), using whole exome sequencing. One variant, c. Read More

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May 2018
3 Reads

High-fluence 1064-nm Q-Switched Nd:YAG laser: Safe and effective treatment of café-au-lait macules in Asian patients.

J Cosmet Dermatol 2018 Jun 3;17(3):380-384. Epub 2018 May 3.

Choice Dermatology Clinic, Pyeongchon, Korea.

Objectives: Café-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Read More

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Macrophage migration inhibitory factor as an incriminating agent in vitiligo.

An Bras Dermatol 2018 Mar;93(2):191-196

Dermatology, Andrology and STDs department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.

Background: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. Read More

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March 2018
2 Reads

Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor.

An Bras Dermatol 2018 Mar;93(2):302-303

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Read More

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March 2018
2 Reads

Pigment dispersion syndrome and pigmentary glaucoma: a review and update.

Int Ophthalmol 2018 May 2. Epub 2018 May 2.

Pathology Centre-Histopathology, Queen Alexandra Hospital, School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK.

Introduction: Potential factors influencing stereopsis were investigated in patients with both refractive accommodative esotropia (RAE) and amblyopia. Pigment dispersion syndrome (PDS) is a condition where anomalous iridozonular contact leads to pigment dispersion throughout the anterior segment and the released pigment is abnormally deposited on various ocular structures.

Clinical Presentation: The clinical presentation of PDS is defined by the presence of pigmented cells on the corneal endothelium, an increase of pigmentation of the trabecular meshwork, and mid-periphery transillumination defects of the iris. Read More

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Complex phenotype of dyskeratosis congenita and mood dysregulation with novel homozygous RTEL1 and TPH1 variants.

Am J Med Genet A 2018 Jun 25;176(6):1432-1437. Epub 2018 Apr 25.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Rockville, Maryland.

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome caused by germline mutations in telomere biology genes. Patients have extremely short telomeres for their age and a complex phenotype including oral leukoplakia, abnormal skin pigmentation, and dysplastic nails in addition to bone marrow failure, pulmonary fibrosis, stenosis of the esophagus, lacrimal ducts and urethra, developmental anomalies, and high risk of cancer. We evaluated a patient with features of DC, mood dysregulation, diabetes, and lack of pubertal development. Read More

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June 2018
5 Reads

Iris Hypoplasia as the Presenting Sign of Retinoblastoma in a Child With a 13q Deletion.

J Pediatr Ophthalmol Strabismus 2018 Apr 23;55:e10-e13. Epub 2018 Apr 23.

Germline partial chromosomal deletions of the entire RB1 gene (13q deletions), account for 6% of the RB1 mutational spectrum. The authors report the rare case of one patient with suspected bilateral iris heterochromia who actually had iris hypoplasia (often masquerading as heterochromia) and bilateral retinoblastoma, due to 13q deletion syndrome. [J Pediatr Ophthalmol. Read More

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April 2018
5 Reads

Manifestations of hypomelanosis of Ito.

Pediatr Neonatol 2018 Apr 5. Epub 2018 Apr 5.

Department of Neurology, University of Kentucky, United States.

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April 2018
1 Read

Eyelash length for the diagnosis of atopic dermatitis and ichthyosis vulgaris in children-a case control study.

Eur J Pediatr 2018 Jun 19;177(6):955-960. Epub 2018 Apr 19.

Department of Dermatology, MVP's Dr. VasantraoPawar Medical College, Flat no. 11, Manomay Apartment, Savatanagar CIDCO, Nashik, Maharashtra, 422008, India.

Eyelash trichomegaly (ET) is increased length (≥ 12 mm), curling, pigmentation, or thickness of eyelashes. Among acquired causes, allergic diseases and atopic dermatitis (AD) have been found to be associated with eyelash trichomegaly especially in children; however, to date, this claim has not been studied in detail. To compare the eyelash lengths of AD and ichthyosis vulgaris (IV) patients with those of age- and sex-matched patients with unrelated skin disorders, we measured (with a digital Vernier caliper) and compared the eyelash lengths of AD (n = 58) and IV (n = 31) patients to those of age- and sex-matched patients with unrelated skin disorders (n = 178). Read More

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June 2018
6 Reads

Scleral Discoloration from Minocycline Treatment.

N Engl J Med 2018 Apr;378(16):1537

Case Western Reserve University School of Medicine, Cleveland, OH

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April 2018
1 Read

A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients.

An Bras Dermatol 2018 Jan-Feb;93(1):54-58

Department of Dermatology and Venereology, National Research Centre - Giza, Egypt.

Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results.

Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egyptian patients with generalized vitiligo.

Methods: This study included 122 vitiligo patients and 200 healthy controls that were age, and gender matched. Read More

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April 2018
2 Reads

Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.

F1000Res 2018 6;7:284. Epub 2018 Mar 6.

Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.

Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

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March 2018
5 Reads

Biochemical aspects of mammalian melanocytes and the emerging role of melanocyte stem cells in dermatological therapies.

Int J Health Sci (Qassim) 2018 Jan-Feb;12(1):69-76

Department of Biotechnology, Saifia Science College, Bhopal, Madhya Pradesh, India.

Skin color in animals is richer than human beings and is determined by different types of pigments. Melanin is the key pigment responsible for the diverse pigmentation found in animal and human skin, hair, and eyes. Melanin pigment is synthesized by melanocytes and is consecutively transferred to adjacent keratinocytes; here, it acts as an internal sunscreen to defend from ultraviolet (UV) damage. Read More

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Formulation of chitosan patch incorporating heartwood extract for improving hyperpigmentation.

J Cosmet Sci 2017 Jul/Aug;68(4):257-269

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000 Thailand (J.K., P.P., J.V.), and International Laboratories Corp. Ltd., Sadhupradist Road, Chongnonsi, Yannawa, Bangkok, 10120 Thailand (S.W.).

heartwood extract contains the bioactive compound artocarpin which exhibits melanogenesis inhibitory activity. However, the extract has poor solubility which affects the skin permeability of the compound. A chitosan hydrogel patch incorporating heartwood extract was formulated to enhance the delivery of an amount of artocarpin sufficient for depigmenting the skin. Read More

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Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Extract in the Treatment of Melasma in Asian Skin: A Pilot Study.

J Clin Aesthet Dermatol 2018 Mar 1;11(3):14-19. Epub 2018 Mar 1.

Drs. Goh, Chuah, and Thng are with the National Skin Centre in Singapore.

Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern (PLE), Fernblock (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Read More

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Mud-splattered fundus.

Indian J Ophthalmol 2018 04;66(4):573

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.

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April 2018
3 Reads

Prevalence of choroidal nevus and retinal pigment epithelial alterations in vitiligo patients.

Graefes Arch Clin Exp Ophthalmol 2018 May 16;256(5):927-933. Epub 2018 Mar 16.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Weizman 6, 6423906, Tel Aviv, Israel.

Purpose: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF).

Methods: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Read More

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May 2018
3 Reads

Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature.

World Neurosurg 2018 Jun 10;114:76-83. Epub 2018 Mar 10.

Department of Neurosurgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China. Electronic address:

Background: To explore the clinical characteristics of neurocutaneous melanosis (NCM) in adult patients to help improve diagnosis and treatment of this disease, we present a rare case of an adult patient suffering from NCM with malignant melanoma, as well as a review of the relevant Chinese and English literature.

Case Description: The patient reported here plus the patients identified in our literature review total 30 adults with NCM (20 males [66.7%] and 10 females [33. Read More

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Altered organization of the visual cortex in FHONDA syndrome.

Neuroimage 2018 Mar 8. Epub 2018 Mar 8.

Department of Ophthalmology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany. Electronic address:

A fundamental scheme in the organization of the early visual cortex is the retinotopic representation of the contralateral visual hemifield on each hemisphere. We determined the cortical organization in a novel congenital visual pathway disorder, FHONDA-syndrome, where the axons from the temporal retina abnormally cross to the contralateral hemisphere. Using ultra-high field fMRI at 7 T, the population receptive field (pRF) properties of the primary visual cortex were modeled for two affected individuals and two controls. Read More

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Pigmentary mosaicism: a review of original literature and recommendations for future handling.

Orphanet J Rare Dis 2018 Mar 5;13(1):39. Epub 2018 Mar 5.

Department of Dermatology and Allergy Centre, J.B. Winsløws Vej 4 , Entrance 142, 5000, Odense C, Denmark.

Background: Pigmentary mosaicism is a term that describes varied patterns of pigmentation in the skin caused by genetic heterogeneity of the skin cells. In a substantial number of cases, pigmentary mosaicism is observed alongside extracutaneous abnormalities typically involving the central nervous system and the musculoskeletal system. We have compiled information on previous cases of pigmentary mosaicism aiming to optimize the handling of patients with this condition. Read More

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March 2018
1 Read

Massive intussusception caused by a solitary Peutz-Jeghers type hamartomatous polyp.

Ann R Coll Surg Engl 2018 Apr 27;100(4):e91-e93. Epub 2018 Feb 27.

Surgical Department, General Hospital of Agrinio , Agrinio, Aitoloakarnania , Greece.

Intussusception is a rare cause of intestinal obstruction in adults and represents a diagnostic challenge for the surgeon. In the majority of cases, presenting symptoms are not specific, making preoperative diagnosis difficult. Several medical conditions may cause intestinal intussusception. Read More

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April 2018
8 Reads

Functional and cosmetic donor site morbidity of the radial forearm-free flap: comparison of two different coverage techniques.

Eur Arch Otorhinolaryngol 2018 May 26;275(5):1219-1225. Epub 2018 Feb 26.

Clinic of Otolaryngology, Head and Neck Surgery and Department of Head Medicine and Oral Health, University Hospital Leipzig, Liebigstr. 12, 04103, Leipzig, Germany.

Background: The use of the radial forearm-free flap is a well-established and reliable reconstruction method in head and neck surgery. Usually, the defect of the donor site is covered with full or split-thickness skin grafts. Since 09/2013, a direct closure of the radial forearm donor site has been performed at the ENT University Hospital Leipzig to avoid secondary donor site morbidity. Read More

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May 2018
2 Reads

Phytophotodermatitis related to carrot extract-containing sunscreen.

Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.

Department of Dermatology, University of California Davis, Sacramento, California, Department of Biological Sciences, California State University Sacramento, Sacramento, California.

Phytophotodermatitis is a clinical diagnosis from phototoxicity of the skin induced by contact with plants or their extracts. Phytophotodermatitis maypresent with burning, erythema, patches, plaques, vesicles, bullae, or hyperpigmented patches in welldemarcated and unusual shapes. Inquiring about occupation, hobbies, and plant or plant extract contact is essential to establishing the diagnosis. Read More

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January 2018
1 Read

An unusual presentation of primary cutaneous amyloidosis.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.

Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. Read More

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August 2017
1 Read

Congenital isolated leukonychia.

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

Department of Dermatology, Louisiana State University, New Orleans, Louisiana.

Congenital leukonychia is a rare nail disorder that may occur in isolation or in association with a number of syndromic disorders. In the following letter, we describe a case of isolated congenital true leukonychia to add to the current literature. This case is particularly unique in that it does not appear to be inherited in an autosomal dominant fashion, in contrast to the majority of reported cases. Read More

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July 2017
1 Read

A pediatric case of unusual melanocytic proliferation of the nail.

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

New York Medical College, Valhalla, New York.

Pigmentation of the nail plate, or melanonychia, is typically a benign condition caused by melanocyte activation. Although rare, melanonychia may be the initial presentation of melanoma, thus all cases require an in-depth examination. Evaluation in pediatric patients can prove especially difficult as benign cases have a higher prevalence of atypia compared to adults. Read More

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Natural options for management of melasma, a review.

J Cosmet Laser Ther 2018 Feb 20:1-12. Epub 2018 Feb 20.

a Laser Research Centre, Faculty of Health Sciences , University of Johannesburg , Doornfontein , South Africa.

A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. Read More

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February 2018
2 Reads

Mucocutaneous Manifestations in Patients with Chronic Kidney Disease: A Cross-sectional Study.

Indian Dermatol Online J 2018 Jan-Feb;9(1):20-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Himachal Pradesh, India.

Background: Chronic kidney disease (CKD)-associated mucocutaneous manifestations significantly impair the quality of life but often remain understudied. They may also vary across regions, socioeconomic and nutritional status, and racial differences.

Objectives: To study the patterns of mucocutaneous disorders and their prevalence in CKD patients irrespective of clinical stage or dialysis status. Read More

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February 2018
4 Reads

TRP‑2 mediates coat color pigmentation in sheep skin.

Mol Med Rep 2018 Apr 6;17(4):5869-5877. Epub 2018 Feb 6.

College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi 030801, P.R. China.

Tyrosinase‑related protein 2 (TRP‑2) is one of the most important members of the tyrosinase family, and is a key enzyme involved in melanin biosynthesis. In the present study, a skin transcriptome profile, immunohistochemistry, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to investigate TRP‑2 expression in sheep with different coat colors, namely, black, white and black‑white. TRP‑2 was overexpressed in melanocytes in order to study the effect of TRP‑2 on melanin production. Read More

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April 2018
1 Read

Dietary intake of glucono-δ-lactone attenuates skin inflammation and contributes to maintaining skin condition.

Food Funct 2018 Mar 12;9(3):1524-1531. Epub 2018 Feb 12.

Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.

Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e. Read More

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Pigmentation Disorders: Diagnosis and Management.

Am Fam Physician 2017 Dec;96(12):797-804

Norton Audobon Hospital, Louisville, KY, USA.

Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

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December 2017
10 Reads

Health Survey of Adults with Neurofibromatosis 1 Compared to Population Study Controls.

J Genet Couns 2018 Feb 10. Epub 2018 Feb 10.

Frambu Resource Centre for Rare Disorders, Sandbakkvn 18, Siggerud, Norway.

Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies have shown impaired health-related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non-clinical NF1 samples. Read More

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February 2018
2 Reads

[Identification of a novel STK11 gene mutation in a family affected with hereditary Peutz-Jeghers syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Feb;35(1):89-91

Unit 8, Department of Ontology Medicine, the Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China. Email:

OBJECTIVE To explore the genetic basis for a family affected with Peutz-Jeghers syndrome (PJS). METHODS Genomic DNA was extracted from peripheral blood and oral swab samples from the patient and her relatives. Next-generation sequencing (NGS) was used to analyze 106 target genes by capturing the exons and adjacent intronic regions. Read More

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February 2018
2 Reads

Cerebellar ataxia-dominant phenotype in patients with ERCC4 mutations.

J Hum Genet 2018 Apr 5;63(4):417-423. Epub 2018 Feb 5.

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Autosomal recessive cerebellar ataxias (ARCAs) are clinically and genetically heterogeneous neurological disorders. Through whole-exome sequencing of Japanese ARCA patients, we identified three index patients from unrelated families who had biallelic mutations in ERCC4. ERCC4 mutations have been known to cause xeroderma pigmentosum complementation group F (XP-F), Cockayne syndrome, and Fanconi anemia phenotypes. Read More

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April 2018
4 Reads

Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin.

Eur J Cell Biol 2018 Apr 1;97(3):150-162. Epub 2018 Feb 1.

Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil; Department of Biology, University of Virginia, Charlottesville, VA, USA. Electronic address:

The mammalian skin has a photosensitive system comprised by several opsins, including rhodopsin (OPN2) and melanopsin (OPN4). Recently, our group showed that UVA (4.4 kJ/m) leads to immediate pigment darkening (IPD) in murine normal and malignant melanocytes. Read More

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April 2018
2 Reads

Factors Affecting Dermatological Manifestations in Patients with End Stage Renal Disease.

J Coll Physicians Surg Pak 2018 Feb;28(2):98-102

Statistician, Government MAO College, Lahore.

Objective: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes.

Study Design: Cross-sectional observational study.

Place And Duration Of Study: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. Read More

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February 2018
3 Reads

Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad-spectrum sunscreens.

Photodermatol Photoimmunol Photomed 2018 Jan 30. Epub 2018 Jan 30.

Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Cutaneous hyperchromias are disorders of skin pigmentation involving increased melanin production and its irregular accumulation in skin cells. The use of sunscreens is fundamental for the control of hyperchromias by reducing the stimulation of pigmentation, as melanin synthesis is mainly stimulated by solar radiation. Many studies have demonstrated that visible light can induce significant skin damage. Read More

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January 2018
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