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J Am Coll Nutr 2020 Jul 10:1-9. Epub 2020 Jul 10.

Think Healthy Group, Washington, DC, USA.

Background: In December 2019, the viral pandemic of respiratory illness caused by COVID-19 began sweeping its way across the globe. Several aspects of this infectious disease mimic metabolic events shown to occur during latent subclinical magnesium deficiency. Hypomagnesemia is a relatively common clinical occurrence that often goes unrecognized since magnesium levels are rarely monitored in the clinical setting. Read More

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Internal Medicine, Ako City Hospital, Ako, Hyogo, Japan.

A 72-year-old Japanese man treated with omeprazole for 11 years was admitted due to loss of consciousness and muscle weakness. Wolff-Parkinson-White syndrome-induced tachycardia was considered as the cause of syncope. His blood examination revealed rhabdomyolysis, hypokalaemia, hypomagnesaemia, hypocalcaemia, hyperlactacidaemia, hyperammonaemia and high-anion-gap metabolic acidosis. Read More

Anticancer Drugs 2020 Jul 3. Epub 2020 Jul 3.

Division of Hematology, Oncology and Tumor Immunology (CCM), Department of Medicine, Charité - Universitaetsmedizin Berlin, Berlin.

Magnesium wasting is a frequent side effect of epidermal growth factor receptor (EGFR)-antibody treatment as magnesium-absorption mechanisms are dependent on EGFR signaling. EGFR-inhibition results in decreased renal reabsorption. There is evidence that hypomagnesemia during cetuximab treatment correlates with response. Read More

BMC Nephrol 2020 Jul 6;21(1):256. Epub 2020 Jul 6.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.

Background: Renal loss of potassium (K) and magnesium (Mg) in salt losing tubulopathies (SLT) leads to significantly reduced Quality of Life (QoL) and higher risks of cardiac arrhythmia. The normalization of K is currently the most widely accepted treatment target, however in even excellently designed RCTs the increase of K was only mild and rarely normalized. These findings question the role of K as the ideal marker of potassium homeostasis in SLT. Read More

Nephrol Ther 2020 Jul 1. Epub 2020 Jul 1.

Département de génétique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Centre de Référence de maladies rénales rares de l'enfant et de l'adulte (MARHEA), Paris, France.

Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartter syndrome is defined by polyhydramnios and an infantile polyuria with severe dehydration whereas classic Bartter syndrome appears during childhood or adulthood. Read More

Acta Myol 2020 Mar 1;39(1):36-39. Epub 2020 Mar 1.

Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Italy.

Mutations of the main voltage-gated K channel members Kv1.1 are linked to several clinical conditions, such as periodic ataxia type 1, myokymia and seizure disorders. Due to their role in active magnesium reabsorption through the renal distal convoluted tubule segment, mutations in the gene encoding for Kv1. Read More

Turk Psikiyatri Derg 2020 ;31(1):69-73

Anorexia nervosa is a disorder that is characterized by excessive preoccupation with body weight and shape, and conscious attempts to stay in low weight due to fear of weight gain. Vomiting, one of the METHODS used by anorexia nervosa patients to stay in low weight, is one of the most important causes of hypokalemia. Diuretics and diarrhea are other common causes of hypokalemia. Read More

J Vet Intern Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Clinical Studies-New Bolton Center (Luethy, Stefanovski, Sweeney), School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Background: Small ruminants presented to tertiary care facilities commonly suffer from severe protein-calorie malnutrition. Some of these patients require parenteral nutrition (PN; amino acids and dextrose with or without lipids) during hospitalization. Refeeding syndrome, a potentially fatal shift of electrolytes seen in malnourished patients during refeeding, may occur. Read More

Nutrients 2020 Jun 19;12(6). Epub 2020 Jun 19.

Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.

Dysmagnesemia is a serious disturbance of microelement homeostasis. The aim of this study was to analyze the distribution of serum magnesium concentrations in hospitalized patients according to gender, age, and result of hospitalization. The study was conducted from February 2018 to January 2019 at the Central Clinical Hospital in Warsaw. Read More

Cureus 2020 May 18;12(5):e8191. Epub 2020 May 18.

Internal Medicine, Brooke Army Medical Center, Fort Sam Houston, USA.

Hypomagnesemia has been associated with a variety of abnormalities, including neurological, cardiac and secondary electrolyte abnormalities. We present the case of a 77-year-old male who presented to the emergency department with tremor and difficulty walking and was found to have severe hypomagnesemia necessitating hospital admission. After thorough workup, the patient's hospital course concluded that the profound hypomagnesemia was secondary to proton pump inhibitor use. Read More

JPEN J Parenter Enteral Nutr 2020 Jun 22. Epub 2020 Jun 22.

The Ohio State University, Division of Trauma, Critical Care, and Burn, Department of Surgery, Columbus, OH, USA.

Background: Initiation of parenteral nutrition (PN) after a period of starvation can be complicated by refeeding syndrome (RFS). RFSs is associated with electrolyte abnormalities including hypomagnesemia, hyponatremia, and most commonly hypophosphatemia. Risk factors associated with the development of RFS include recent weight loss, low BMI, and electrolyte deficiencies, however, these associations are not strong. Read More

Am J Cardiol 2020 May 15. Epub 2020 May 15.

Department of Medicine, Section of Cardiac Electrophysiology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. Electronic address:

Electrolyte abnormalities are a known trigger for ventricular arrhythmia, and patients with heart disease on diuretic therapy may be at higher risk for electrolyte depletion. Our aim was to determine the prevalence of electrolyte depletion in patients presenting to the hospital with sustained ventricular tachycardia or ventricular fibrillation (VT/VF) versus heart failure, and identify risk factors for electrolyte depletion. Consecutive admissions to a tertiary care hospital for VT/VF were identified between July 2016 and October 2018 using the electronic medical record and compared with an equal number of consecutive admissions for heart failure (CHF). Read More

Circ J 2020 Jun 18. Epub 2020 Jun 18.

Department of Pathophysiology, Oita University School of Medicine.

Background: Mechanisms for QT interval prolongation and cardiac arrhythmogenesis in hypomagnesemia are poorly understood. This study investigated the potential molecular mechanism for QT prolongation caused by magnesium (Mg) deficiency in rats by using the patch clamp technique and molecular biology.Methods and Results:Male Wistar rats were fed an Mg-free diet or a normal diet for up to 12 weeks. Read More

Front Oncol 2020 27;10:817. Epub 2020 May 27.

Biocubafarma, Havana, Cuba.

EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3-4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Read More

Breast Cancer Res Treat 2020 Aug 10;182(3):719-726. Epub 2020 Jun 10.

Department of Medical Oncology, Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Purpose: Cisplatin, an effective medication for metastatic breast cancer (MBC), is recommended to be applied at the dose of 75 mg/m on day 1 every 3 weeks. However, the 75 mg/m schedule is often associated with a variety of side effects (such as vomiting and kidney toxicity), and time-consuming hydration treatment is usually needed. Divided dose (25 mg/m on day 1-3) without hydration is an alternative. Read More

Int Urol Nephrol 2020 Jun 8. Epub 2020 Jun 8.

Division of Nephrology, Department of Internal Medicine, Selcuk University Faculty of Medicine, Konya, Turkey.

Purpose: An inverse association was shown between serum magnesium levels and anemia in the general population. However, limited information is available about the association between serum magnesium level and anemia in the patient population with chronic kidney disease. We aimed to investigate the relationship between hypomagnesemia and anemia in pre-dialysis patients with chronic kidney disease stage 3-5. Read More

Ann Palliat Med 2020 May;9(3):1134-1143

Beijing Xiaotangshan Hospital Medical Laboratory, Beijing 102211, China.

Background: In recent years, the concentration of magnesium in dialysis patients has drawn an increasing amount of attention. Both hemodialysis and peritoneal dialysis may affect magnesium metabolism, but studies in this area are very limited. This study aimed to investigate the serum magnesium concentrations in hemodialysis patients and examine the factors related to the serum magnesium concentration, and to explore the effect of hemodialysis with conventional hemodialysis solution (magnesium ion concentration 0. Read More

Nutrients 2020 Jun 2;12(6). Epub 2020 Jun 2.

La Isla Network, 1441 L Street NW, Washington, DC 20005, USA.

Background: Chronic kidney disease of non-traditional origin (CKDnt) is common among Mesoamerican sugarcane workers. Recurrent heat stress and dehydration is a leading hypothesis. Evidence indicate a key role of inflammation. Read More

Cureus 2020 Apr 27;12(4):e7854. Epub 2020 Apr 27.

Nephrology, University of Florida Health, Gainesville, USA.

We report a patient who presented with anxiety, hyperventilation, perioral paresthesia, and tingling in the fingers associated with hypomagnesemia, hypocalcemia, and hypokalemia. We discuss the possible mechanistic basis for sequence of events that may have led to this presentation. Read More

J Vet Med Sci 2020 May 25. Epub 2020 May 25.

Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University.

This study was performed to confirm the alterations of blood and urine parameters in artificially induced hypocalcemic cows. For a 2 х 2 cross-over design, four non-pregnant, non-lactating Holstein Friesian cows (622.5 ± 63. Read More

J Biol Chem 2020 May 21. Epub 2020 May 21.

University of Toronto, Canada.

Type 2 diabetes (T2D) is a chronic metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance. Among individuals with T2D, approximately 30% exhibit hypomagnesemia. Hypomagnesemia has been linked to insulin resistance through reduced tyrosine kinase activity of the insulin receptor; however, its impact on pancreatic β-cell function is unknown. Read More

Acta Biomed 2020 May 11;91(2):365-372. Epub 2020 May 11.

University of Parma.

Background: Posterior reversible encephalopathy (PRES) is a rare syndrome characterized by headache, confusion, seizures, visual changes and white matter edema at radiological imaging. Its pathophysiology is not clarified and different causes, including uncontrolled hypertension, eclampsia, chemotherapy and hypomagnesemia have been suggested.

Case Report: A woman affected by stage IV breast cancer with lower extremity deep vein thrombosis treated with low-molecular-weight-heparin, currently in therapy with Palbociclib/Fulvestrant (antiCDK4 and 6/estrogen receptor antagonist) but previously treated with several other chemotherapy lines (including VEGF inhibitor bevacizumab), was admitted to our Internal Medicine department because of ascites and abdominal pain. Read More

Clin Transplant 2020 May 14:e13902. Epub 2020 May 14.

Heart Failure and Heart Transplant Program, CardioThoracic and Vascular Department, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Background: Patients with advanced heart failure undergoing heart transplant (HTx) or left ventricular assist device (LVAD) implant are at high risk of magnesium deficiency, that may favor development of diabetes. We aimed to comparatively assess prevalence and correlates of hypomagnesemia during cardiac rehabilitation between 51 HTx and 46 LVAD recipients.

Methods And Results: We measured serum magnesium and correlated it to clinical and laboratory findings upon admission (T ) and at discharge (T2) from cardiac rehabilitation. Read More

Gan To Kagaku Ryoho 2020 Apr;47(4):605-608

Dept. of Pharmacy, Shizuoka Cancer Center.

The efficacy of magnesium oxide(MgO)when taken daily as a laxative for hypomagnesemia and renal dysfunction due to cisplatin(CDDP)administration is not clear. It is known that the efficacy of MgO is suppressed when used in combination with antacids, such as proton pump inhibitors. Therefore, we conducted a retrospective analysis of the effects of MgO and antacid administration on serum Mg levels and renal function(estimated glomerular filtration rate: eGFR)in CDDP-treated patients. Read More

Pediatr Nephrol 2020 May 10. Epub 2020 May 10.

Department of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.

Background: Hypomagnesemia in patients with congenital anomalies of the kidneys and urinary tract or autosomal dominant tubulointerstitial kidney disease is highly suggestive of HNF1B-associated disease. Intriguingly, the frequency of low serum Mg (sMg) level varies and is lower in children than in adults with HNF1B mutations that could be partially due to application of inaccurate normal limit of sMg, irrespective of age and gender. We aimed to re-assess cross-sectionally and longitudinally the frequency of hypomagnesemia in HNF1B disease by using locally derived reference values of sMg. Read More

Biol Trace Elem Res 2020 May 6. Epub 2020 May 6.

Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, ul. Jordana 19, 41-808, Zabrze, Poland.

Occupational exposure to lead is one of the important hazards to human global population. Lead interferes with divalent cations, such as calcium, magnesium, and iron. Magnesium is the fourth most common mineral in the human body and a cofactor in more than 325 enzymes. Read More

J Pediatr Orthop B 2020 May 2. Epub 2020 May 2.

Orthopedic Department, UPR Medical Sciences Campus, San Juan.

Adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF) usually require surveillance in the pediatric ICU (PICU). Some reports have documented evidence of hypomagnesemia following PSF at PICU. Little has been studied about relationship between AIS and postoperative serum magnesium (Mg+2) levels. Read More

Endocrinol Diabetes Metab Case Rep 2020 May 5;2020. Epub 2020 May 5.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Summary: Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder (OMIM# 602014) characterized by profound hypomagnesemia associated with hypocalcemia. It is caused by mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6). It usually presents with neurological symptoms in the first months of life. Read More

Leuk Lymphoma 2020 May 2:1-3. Epub 2020 May 2.

Division of Hematology Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Cureus 2020 Mar 26;12(3):e7426. Epub 2020 Mar 26.

Internal Medicine, University College of Medicine, University of Lahore, Lahore, PAK.

Background Among the dialysis population, left ventricular hypertrophy (LVH) is becoming a major cause of cardiovascular death, mainly due to myocardial infarction, heart failure, and arrhythmias. Electrocardiography (ECG) is a cheap and easily available test to detect the presence of left ventricular hypertrophy. The basic purpose of this study was to assess the frequency of left ventricular hypertrophy among the maintenance hemodialysis patients by applying different voltage criteria for the diagnosis of LVH and its relationship with various biophysical and biochemical parameters. Read More

Exp Hematol Oncol 2020 20;9. Epub 2020 Apr 20.

3Sarah Cannon Research Institute at HealthONE, Denver, CO USA.

Background: Angiogenesis and activation of the epidermal growth factor (EGFR) pathway play an essential role in tumor proliferation and metastasis. Targeting angiogenesis or EGFR alone does not yield adequate tumor control in most solid tumors. Overcoming intrinsic and/or acquired resistance may need a doublet or triplet therapy strategy. Read More

Int J Mol Sci 2020 Apr 17;21(8). Epub 2020 Apr 17.

Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA.

Mutations in the gene, which encodes voltage-gated Kv1.1 potassium channel α-subunits, cause a variety of human diseases, complicating simple genotype-phenotype correlations in patients. mutations are primarily associated with a rare neurological movement disorder known as episodic ataxia type 1 (EA1). Read More

Kidney Dis (Basel) 2020 Mar 11;6(2):109-118. Epub 2019 Dec 11.

Department of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Background: The relationship between magnesium and mortality in hemodialysis patients has been evaluated in several prospective studies, but few have assessed the risk of all-cause mortality in elderly hemodialysis patients. The aim of this study was to evaluate the association between magnesium levels and the risk of cardiovascular and overall mortality in elderly maintenance hemodialysis patients.

Methods: This was a retrospective study, and patients undergoing maintenance hemodialysis were screened for eligibility at a single dialysis center between July and December 2016. Read More

Int J Endocrinol Metab 2020 Jan 14;18(1):e97292. Epub 2020 Jan 14.

Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Serum magnesium (Mg) status in kidney transplant recipients has been a center of attention in the past few years. Current evidence suggests an association between pre-transplant hypomagnesemia and post-transplant hyperglycemia.

Objective: The purpose of this study was to assess the associations of pre-transplant magnesemia with blood glucose disturbances within 6 months post-kidney transplantation. Read More

J Clin Res Pediatr Endocrinol 2020 04 17. Epub 2020 Apr 17.

Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Department of Pediatrics, Ankara, Turkey.

Background: Hypomagnesemia is a rare cause of seizures in childhood. But should be in mind in recurrent and intractable seizures and hypocalcemia the communities where consanguineous marriages are common. Familial hypomagnesemia with secondary hypocalcemia is a rare genetic cause of hypomagnesemia due to the variant in the transient receptor potential melastatin 6 genes. Read More

Reumatismo 2020 Apr 10;72(1):67-70. Epub 2020 Apr 10.

Unit of Rheumatology, Università di Modena e Reggio Emilia, Modena.

Gitelman syndrome (GS) is an inherited salt-wasting tubulopathy characterized by hypocalciuria, hypokalemia, hypomagnesemia and metabolic alkalosis, due to inactivating mutations in the SLC12A3 gene. Symptoms may be systemic, neurological, cardiovascular, ophthalmological or musculoskeletal. We describe a 70 year-old patient affected by recurrent arthralgias, hypoesthesia and hyposthenia in all 4 limbs and severe hypokalemia, complicated by atrial flutter. Read More

Nutrients 2020 Apr 8;12(4). Epub 2020 Apr 8.

Department of Physiology, School of Pharmacy, University of Granada, 18071 Granada, Spain.

Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize the biases derived from diet measurement, more objective biomarkers of magnesium status have been proposed. Read More

Front Vet Sci 2020 17;7:97. Epub 2020 Mar 17.

Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.

Clinical safety data for the use of gastroprotectants in hospitalized ruminants is lacking. In human patients, multiple adverse effects are possible from the use of pantoprazole including hematologic and electrolyte abnormalities as well as anaphylaxis and edema. The medical records of all hospitalized cattle, goats, and sheep administered pantoprazole over an ~5-year period were retrospectively analyzed for adverse effects. Read More

J Obstet Gynaecol Can 2020 Jun 29;42(6):750-756. Epub 2020 Mar 29.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Mount Sinai Hospital, Toronto, ON; Department of Medicine, University of Toronto, Toronto, ON; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.

Objective: We sought to describe the maternal, fetal, and neonatal outcomes of primary hyperparathyroidism in a contemporary setting through a retrospective case series conducted in a tertiary referral centre focused on women diagnosed with primary hyperparathyroidism prior to conception, in the antepartum period, or within 6 weeks postpartum.

Methods: A retrospective chart review was conducted and data were abstracted to case report forms. Summary statistics are reported. Read More

Am J Cardiol 2020 May 5;125(10):1517-1523. Epub 2020 Mar 5.

Heart Transplantation Unit, Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Israel. Electronic address:

Hypomagnesemia is commonly observed in heart transplant (HT) recipients receiving calcineurin inhibitors. Since low serum magnesium (s-Mg) has been implicated in the progression of atherosclerosis, potentially leading to worsening coronary heart disease, arrhythmias and sudden death, we investigated the association between s-Mg and HT outcomes. Between 2002 and 2017, 150 HT patients assessed for s-Mg were divided into high (≥1. Read More

World J Gastroenterol 2020 Mar;26(11):1142-1155

Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.

Background: The exact mechanism of proton pump inhibitors (PPIs)-induced hypomagnesemia (PPIH) is largely unknown. Previous studies proposed that PPIH is a consequence of intestinal Mg malabsorption. However, the mechanism of PPIs-suppressed intestinal Mg absorption is under debate. Read More

Blood Rev 2020 Mar 27:100676. Epub 2020 Mar 27.

Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

Magnesium is an important element that has essential roles in the regulation of cell growth, division, and differentiation. Mounting evidence in the literature suggests an association between hypomagnesemia and all-cause mortality. In addition, epidemiologic studies have demonstrated that a diet poor in magnesium increases the risk of developing cancer, highlighting its importance in the field of hematology and oncology. Read More

Indian Pediatr 2020 May 12;57(5):415-419. Epub 2020 Mar 12.

Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Objective: To study the etiological profile and patterns of clinical presentation of nephrocalcinosis.

Methods: In this observational study, patients 18 years or younger, referred to the pediatric nephrology clinic with nephrocalcinosis were evaluated for etiology. Symptoms/signs at presentation, estimated glomerular filtration rate (eGFR) at presentation and follow-up, and growth parameters were recorded. Read More

Hosp Pharm 2020 Apr 2;55(2):84. Epub 2020 Jan 2.

WakeMed Health & Hospitals, Raleigh, NC, USA.

Hosp Pharm 2020 Apr 18;55(2):82-83. Epub 2019 Dec 18.

The University of Texas MD Anderson Cancer Center, Houston, USA.

Seizure 2020 May 20;78:172-173. Epub 2020 Mar 20.

Department of Life Sciences, National Natural Science Foundation of China, Beijing, China. Electronic address:

Genes (Basel) 2020 03 10;11(3). Epub 2020 Mar 10.

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.

Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial cells. In the mammalian kidney, every tubular segment express a specific set of claudins that give to that segment unique properties regarding permeability and selectivity of the paracellular pathway. So far, 3 claudins (10b, 16 and 19) have been causally traced to rare human syndromes: variants of cause HELIX syndrome and variants of or cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Read More

Adv Chronic Kidney Dis 2020 01;27(1):56-66

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation. Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities can plague kidney transplant recipients. By 10 years, virtually all allografts will have evidence of CNI nephrotoxicity. Read More

Invest New Drugs 2020 Mar 7. Epub 2020 Mar 7.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB, Groningen, the Netherlands.

Background Metformin use is associated with reduced cancer risk in epidemiological studies and has preclinical anti-cancer activity in ovarian cancer models. The primary objective of this phase I study was to determine the recommended phase II dose (RP2D) of metformin in combination with carboplatin/paclitaxel in patients with ovarian cancer. Secondary objectives were to describe safety and pharmacokinetics. Read More

Parkinsonism Relat Disord 2020 03 2;72:80-81. Epub 2020 Mar 2.

Department of Neurology, ASL To4, Ivrea, Italy.