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    Hypokalemia associated with pseudo-Cushing's syndrome and magnesium deficiency induced by chronic alcohol abuse.
    CEN Case Rep 2018 Feb 15. Epub 2018 Feb 15.
    Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
    Hypokalemia and hypomagnesemia are frequently observed in patients with chronic alcoholism. However, the involvement of deranged cortisol regulation in patients with those conditions has not been reported. A 63-year-old Japanese male with chronic alcoholism was referred to the Department of Diabetes, Endocrinology and Metabolism for examination and treatment of hypokalemic periodic paralysis. Read More

    Analysis of patients with hypomagnesemia using the Japanese Adverse Drug Event Report database (JADER).
    J Pharm Pharm Sci 2018 ;21(1):46-53
    Department of Practical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
    Purpose: In order to clarify the occurrence of hypomagnesemia in Japan, we conducted a database search and analysis using the Japanese Adverse Drug Event Report database (JADER).

    Methods: Among the cases recorded in JADER between April 2004 and December 2015, we targeted "hypomagnesemia" and analyzed the patients' backgrounds, drug involvement, other adverse events reported with hypomagnesemia, the time of hypomagnesemia onset, outcomes, and year when reported. For drugs with three or more reports, the signal index was calculated using the Reporting Odds Ratio (ROR) method. Read More

    Analysis of the necessity of serum electrolyte monitoring for up to eight weeks after the completion of anti-epidermal growth factor receptor antibody administration.
    • Authors:
    Pharmazie 2016 Jul;71(7):402-407
    Electrolyte disturbances are a known side effect of cetuximab (cmab) and panitumumab (pmab) administration and monitoring is recommended during and for at least 8 weeks after pmab administration. However, the recommended duration of electrolyte monitoring is not stated on the cmab package insert in the EU or Japan and no previous studies have investigated the appropriate monitoring period for cmab and pmab. We retrospectively investigated electrolyte levels in 16 cmab-treated patients and 7 pmab-treated patients between 1 June 2009 and 31 December 2014. Read More

    Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients.
    Pediatr Transplant 2018 Feb 7. Epub 2018 Feb 7.
    Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Universidad Austral, Pilar, Argentina.
    Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for NE after LT in pediatric and adult recipients. A single-center cohort study, including all LT between 2001 and 2013, was performed. Read More

    Proton Pump Inhibitors: Review of Emerging Concerns.
    Mayo Clin Proc 2018 Feb;93(2):240-246
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address:
    First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache. Read More

    In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques.
    J Pharm Anal 2017 Oct 22;7(5):332-337. Epub 2017 Mar 22.
    Trivedi Science Research Laboratory Pvt. Ltd., Bhopal 462026, Madhya Pradesh, India.
    Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on solid state propertiesphysicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like PXRD, PSA, FT-IR, UV-Vis spectroscopy, TGA/DTG, and DSC. Magnesium gluconate was found to be crystalline in nature along with the crystallite size ranging from 14. Read More

    Two mutations in the thiazide-sensitive NaCl co-transporter gene in a Romanian Gitelman syndrome patient: case report.
    Ther Clin Risk Manag 2018 22;14:149-155. Epub 2018 Jan 22.
    Department of Functional Sciences.
    Background: Gitelman syndrome (GS) is considered as the most common renal tubular disorder, and we report the first Romanian patient with GS confirmed at molecular level and diagnosed according to genetic testing.

    Patient And Methods: This paper describes the case of a 27-year-old woman admitted with severe hypokalemia, slight hypomagnesemia, hypocalcemia, hypocalciuria, metabolic alkalosis, hyperreninemia, low blood pressure, limb muscle weakness, marked fatigue and palpitations. Family history revealed a consanguineous family with autosomal-recessive transmission of GS with two cases over five generations. Read More

    Hypomagnesemia and clinical benefits of anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer: a systematic review and meta-analysis.
    Sci Rep 2018 Feb 1;8(1):2047. Epub 2018 Feb 1.
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Hypomagnesemia is a recognized side-effect of cetuximab- or panitumumab-based chemotherapy for metastatic colorectal cancer (mCRC). The clinical relevance of hypomagnesemia is under debate. Thus, a systematic review and meta-analysis of retrospective studies and randomized clinical trials (RCTs) comparing hypomagnesemia with normal magnesium levels in wild-type KRAS mCRC was performed. Read More

    A novel compound heterozygous variant of the SLC12A3 gene in Gitelman syndrome pedigree.
    BMC Med Genet 2018 Jan 29;19(1):17. Epub 2018 Jan 29.
    Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, 3 East Qing Chun Road, Zhejiang, Hangzhou, 310016, China.
    Background: Gitelman syndrome (GS) is an autosomal recessive disorder caused by genic mutations of SLC12A3 (Solute carrier family 12 member 3), which encodes the Na-Cl cotransporter (NCC), and presents with characteristic metabolic abnormalities, including hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. In this study, we report a case of a GS pedigree, including analysis of GS-associated gene mutations.

    Methods: We performed next-generation sequencing analysis and Sanger sequencing to explore the SLC12A3 mutations in a GS pedigree that included a 35-year-old female patient with GS and five family members within three generations. Read More

    Coexistence of Gitelman Syndrome and Hypertrophic Cardiomyopathy in a Pregnant Woman.
    Acta Cardiol Sin 2018 Jan;34(1):92-95
    Faculty of Medicine, Department of Cardiology, Yıldırım Beyazıt University, Ankara, Turkey.
    Gitelman syndrome (GS) is transmitted as an autosomal recessive trait and characterized by hypokalemic metabolic alkalosis in combination with significant hypomagnesemia and low urinary calcium excretion. The symptoms and severity of the disease can vary greatly from one person to another and can range from mild to severe. Sudden cardiac arrest has been reported occasionally as well. Read More

    Serum Total Magnesium Level and its Correlation with Symptom Control in Children with Mild Persistent Asthma.
    Indian J Pediatr 2018 Jan 19. Epub 2018 Jan 19.
    Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Objectives: To determine the prevalence of hypomagnesemia in children with mild persistent asthma and to correlate the serum magnesium levels with symptom control in the above children.

    Methods: It was a cross sectional study carried out from 1st April 2015 to 31st July 2016 at the department of Pediatrics, JIPMER Hospital. Participants included six to 12-y-old children with mild persistent asthma registered at childhood asthma clinic. Read More

    Effect of Short Hydration on Cisplatin-Induced Nephrotoxicity in Cancer Patients: A Retrospective Study.
    Int J Hematol Oncol Stem Cell Res 2017 Oct;11(4):262-267
    Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    The aim of this study was to evaluate the protective role of short hydration against nephrotoxicity induced by cisplatin (CDDP).Twenty-two patients (13 men and 9 women) under CDDP therapy were enrolled in this retrospective study between 2009 and 2014. The CDDP was given in 500 ml of isotonic solution, and before and after CDDP administration, the patients received 10mEq potassium chloride15% and 1gr magnesium sulfate in 1000 ml isotonic saline. Read More

    Extracorporeal membrane oxygenation combined with continuous renal replacement therapy in cutaneous burn and inhalation injury caused by hydrofluoric acid and nitric acid.
    Medicine (Baltimore) 2017 Dec;96(48):e8972
    Department of Critical Care Medicine, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
    Rationale: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. Read More

    Magnesium deficiency affects HNF1β expression in rat liver in vivo and in vitro.
    Magnes Res 2017 Aug;30(3):98-105
    PEPITE EA4267, laboratoire de toxicologie cellulaire, Université Bourgogne-Franche-Comté, 25000 Besançon, France.
    Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor that is involved in embryonic development and tissue-specific gene expression in several organs, including the kidney and the liver. HNF1β mutations are associated with hypomagnesemia and renal magnesium wasting; however, to date, the exact molecular mechanism involved in this regulation is unclear. Furthermore, it is not known whether the Mg concentration could per se participate to this regulation by modifying HNF1β expression. Read More

    Trifluoroacetic acid: Three times the fluoride, three times the toxicity?
    Am J Emerg Med 2017 Dec 12. Epub 2017 Dec 12.
    Division of Medical Toxicology, University of California San Diego, San Diego, CA 92103, USA; Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103, USA.
    Trifluoroacetic acid (TFAA) is a carboxylic acid, similar to acetic acid, used industrially and in laboratories. There is a paucity of data regarding exposure and the concern is that toxicity may mimic that of hydrofluoric acid (HF), causing electrolyte abnormalities, dysrhythmia, and cardiac arrest. We report a case of a 27-year-old male that presents with a dermal exposure to TFAA. Read More

    Prevalence of Hypocalcemia in Seizures in Infancy.
    Indian J Pediatr 2017 Dec 16. Epub 2017 Dec 16.
    KLE University, Belgaum, Karnataka, India.
    A one-year prospective study on developmentally normal children between 1-mo to 2-y with seizures was done to study the prevalence of hypocalcemia. The contribution of hypovitaminosis-D to hypocalcemia was also studied. Of 78 infants (51 boys) enrolled, 18 (23. Read More

    Serum Magnesium Abnormality and Influencing Factors of Serum Magnesium Level in Peritoneal Dialysis Patients: A Single-Center Study in Northern China.
    Blood Purif 2017 Dec 14;45(1-3):110-117. Epub 2017 Dec 14.
    Background/aims: Both hypomagnesemia and hypermagnesemia have been associated with cardiovascular diseases, bone diseases, and mortality in dialysis patients. We aimed to investigate the prevalence of and influencing factors for abnormal serum Mg levels in patients on peritoneal dialysis (PD).

    Methods: A cross-sectional study in Peking University People's Hospital recorded the demographic information, clinical characteristics, and laboratory data. Read More

    Xanthogranulomatous pyelonephritis in a paediatric cohort (1963-2016): Outcomes from a large single-center series.
    J Pediatr Urol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Surgery, Division of Paediatric Urology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland.
    Background: Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. Read More

    Georgian Med News 2017 Nov(272):118-127
    Republic of Kazakhstan, Semey State Medical University, Department of aftergraduated and additional education.
    The frequency of the combination of congenital heart defects (CHD) and connective tissue dysplasia remains poorly understood. And connective tissue dysplasia enhance severity the clinical of CHD. The aim of the study was to conduct a clinical and laboratory analysis of combinations of congenital heart defects and connective tissue dysplasia in children of Semey and to determine the risk for the development of these pathologies. Read More

    Adverse events of proton pump inhibitors: potential mechanisms.
    Curr Drug Metab 2017 Dec 7. Epub 2017 Dec 7.
    Department of Clinical and Experimental Medicine, University of Messina. Italy.
    Objective: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of proton pump inhibitors (PPIs).

    Methods: A Pubmed search was performed, and 207 studies concerning the relationship between use of PPIs and cardiovascular diseases, kidney impairment, nutritional disorders, fractures, infections, functional decline, and mortality were selected and reviewed.

    Results: PPIs may cause potentially harmful effects by several mechanisms, including endothelial dysfunction, hypomagnesemia, drug interactions, reduced absorption of selected nutrients, increased gastric microbiota and small intestine bacterial overgrowth, reduced immune response, tubular-interstitial inflammation, increased bone turnover, accumulation of amyloid in the brain. Read More

    What is the long term acid inhibitor treatment in gastroesophageal reflux disease? What are the potential problems related to long term acid inhibitor treatment in gastroesophageal reflux disease? How should these cases be followed?
    Turk J Gastroenterol 2017 12;28(Suppl 1):S57-S60
    Division of Rheumatology, Department of Internal Medicine, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
    The meta-analyses of observational studies (OBS) showed the risk of any fracture and hip fracture slightly increased with proton pump inhibitor (PPI) treatment depending on the dose and regardless of time. This was not observed with histamine-2 receptor antagonists (H2RA). The risk of bacterial overgrowth and spontaneous bacterial peritonitis were increased with PPI therapy, but not with H2RA. Read More

    Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs.
    Kidney Blood Press Res 2017 27;42(6):974-982. Epub 2017 Nov 27.
    Background/aims: Maternal hypercholesterolemia is a risk factor to renal injury in rat pups at adulthood, especially if they feed a cholesterol-enriched diet after weaning. However, the renal function of male pups of dams with hypercholesterolemia (PH) that were fed a regular chow from weaning to adulthood needs investigation, particularly those exposed to an adverse risk such as nicotine.

    Methods: We evaluated the renal function of PH animals and we compared the data with those found in male pups of control dams (PC) at 3- and 6-month-old by inulin clearance. Read More

    Hypermagnesuria in Humans Following Acute Intravenous Administration of Digoxin
    Nephron 2017 10 30. Epub 2017 Oct 30.
    Department of Medicine E, Sheba Medical Center, Ramat Gan, Israel
    Background: Hypomagnesemia is a known predisposing condition for the appearance of digitalis toxicity. The detection of a genetic form of Mg urinary wasting with hypomagnesemia being caused by a mutation in the γ subunit (FXYD2) of the Na,K-ATPase, the pharmacological target of Digoxin, prompted us to investigate whether Digoxin administration increases urinary Mg excretion.

    Methods: Two groups of subjects, with rapid atrial fibrillation, received intravenous Digoxin (n = 9) or verapamil (n = 8), for heart rate control. Read More

    Digoxin and Hypermagnesuria.
    Nephron 2017 11 23. Epub 2017 Nov 23.
    Department of Clinical and experimental Medicine, Section of Nephrology, University of Catania, Catania, Italy.
    In a recent issue of Nephron, Abu-Amer et al.[ref 1] reported the presence of hypermagnesuria in patients following acute intravenous administration of digoxin and suggested that the Na+/K+-ATPase γ-subunit, which is the pharmacological target of digoxin, can play a role in this process. Hypermagnesuria induced by digoxin may have important clinical consequences, particularly in the presence of inherited and acquired conditions associated with hypermagnesuria and hypomagnesemia. Read More

    Is hungry bone syndrome a cause of postoperative hypocalcemia after total thyroidectomy in thyrotoxicosis? A prospective study with bone mineral density correlation.
    Surgery 2018 Feb 14;163(2):367-372. Epub 2017 Nov 14.
    Department of Endocrine Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.
    Background: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. Read More

    A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure.
    Sci Rep 2017 Nov 15;7(1):15623. Epub 2017 Nov 15.
    Rutgers-Robert Wood Johnson Medical School, Deptartment of Pharmacology, Piscataway, 08854, USA.
    In humans, germline mutations in Trpm6 cause autosomal dominant hypomagnesemia with secondary hypocalcemia disorder. Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally results in early embryonic lethality and neural tube closure defects. To define the mechanisms by which TRPM6 influences neural tube closure, we functionally characterized the role of TRPM6 during early embryogenesis in Xenopus laevis. Read More

    Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.
    Kidney Int 2017 Nov 10. Epub 2017 Nov 10.
    Institute of Physiology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Electronic address:
    The tight junction proteins claudin-10 and -16 are crucial for the paracellular reabsorption of cations along the thick ascending limb of Henle's loop in the kidney. In patients, mutations in CLDN16 cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis, while mutations in CLDN10 impair kidney function. Mice lacking claudin-16 display magnesium and calcium wasting, whereas absence of claudin-10 results in hypermagnesemia and interstitial nephrocalcinosis. Read More

    Chronic use of proton pump inhibitors, adverse events and potential biological mechanisms: A translational analysis.
    Therapie 2017 Oct 14. Epub 2017 Oct 14.
    Regional pharmacovigilance centre of Marseille Provence Corse, department of clinical pharmacology and pharmacovigilance, Assistance publique-Hôpitaux de Marseille, 270, boulevard Sainte-Marguerite, 13009 Marseille, France; CNRS 7289, neurosciences institute Timone, Aix-Marseille university, 13009 Marseille, France. Electronic address:
    Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI are usually considered as safe, there is a growing concern for a range of adverse effects of chronic PPI therapy often in the absence of appropriate indications. We propose, after a summary of renal, cardiovascular and neurological complications (dementia, chronic kidney disease, myocardial infarction and stroke), an integrative overview of the potential biological mechanisms involved. Read More

    Prevention of Chemotherapy-Induced Nephrotoxicity in Children with Cancer.
    Int J Prev Med 2017 5;8:76. Epub 2017 Oct 5.
    Department of Pediatrics, Division of Nephrology, Rush University Medical Center, Chicago, Illinois, USA.
    Children with cancer treated with cytotoxic drugs are frequently at risk of developing renal dysfunction. The cytotoxic drugs that are widely used for cancer treatment in children are cisplatin (CPL), ifosfamide (IFO), carboplatin, and methotrexate (MTX). Mechanisms of anticancer drug-induced renal disorders are different and include acute kidney injury (AKI), tubulointerstitial disease, vascular damage, hemolytic uremic syndrome (HUS), and intrarenal obstruction. Read More

    A Population-Based Study of the Epidemiology of Chronic Hypoparathyroidism.
    J Bone Miner Res 2017 Oct 31. Epub 2017 Oct 31.
    Department of Medicine, University of Dundee, Dundee, UK.
    There are very few reports on the epidemiology of chronic hypoparathyroidism. A population-based study was undertaken to describe the prevalence and incidence of hypoparathyroidism in Tayside, Scotland. Data on biochemistry, hospital admissions, prescribing, and death records in Tayside, Scotland, from 1988 to 2015 were linked electronically. Read More

    Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication.
    World J Gastroenterol 2017 Oct;23(37):6907-6910
    Department of Gastroenterology, Zealand University Hospital, 4600 Køge, Denmark.
    Magnesium deficiency can cause a variety of symptoms, including potentially life-threatening complications such as seizures, cardiac arrhythmias and secondary electrolyte disturbances. Hypomagnesemia can be a serious adverse effect to proton pump inhibitor (PPI) therapy, which is worrying due to the widespread use of PPIs. Current evidence suggest that the mechanism of PPI induced hypomagnesemia is impaired intestinal magnesium absorption. Read More

    Secondary Hyperparathyroidism in Heart Failure.
    Am J Med Sci 2017 Oct 2;354(4):335-338. Epub 2017 Mar 2.
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:
    Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Caand Mgwasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Caoverloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Read More

    Unusual Complication of Multidrug Resistant Tuberculosis.
    Case Rep Nephrol 2017 18;2017:6835813. Epub 2017 Sep 18.
    Division of Medicine, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai 400 012, India.
    Introduction: Capreomycin is a second-line drug often used for multidrug-resistant tuberculosis which can result in nephrotoxic effects similar to other aminoglycosides. We describe a case of capreomycin induced Bartter-like syndrome with hypocalcemic tetany.

    Case Report: 23-year-old female patient presented with carpopedal spasms and tingling sensations in hands. Read More

    A Case of Renal Tubular Acidosis with Sjogren's Syndrome Showing Paradoxical Block of PTH Due to Severe Hypomagnesemia.
    Indian J Clin Biochem 2017 Oct 18;32(4):496-499. Epub 2016 Dec 18.
    Sundaram Medical Foundation, Dr. Rangarajan Memorial Hospital, 9C, IV Avenue, Shanthi Colony, Anna Nagar, Chennai, 600040 India.
    Distal renal tubular acidosis (RTA) manifests either as Complete/Classical form or Incomplete/Latent Form. Distal RTA causes normal anion gap metabolic acidosis and hypokalemia. Interstitial Nephritis is the most frequent renal manifestation of Sjogren's, which presents as Distal RTA in 25-40% of patients with Sjogren's syndrome. Read More

    Micronutrients Drift During Daily and Weekly Iron Supplementation in Non-anaemic and Anaemic Pregnancy.
    Indian J Clin Biochem 2017 Oct 17;32(4):473-479. Epub 2017 Jan 17.
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
    Aims: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum. Read More

    Incidence of hyperglycemia and diabetes and association with electrolyte abnormalities in pediatric solid organ transplant recipients.
    Nephrol Dial Transplant 2017 Sep;32(9):1579-1586
    Department of Pediatrics, Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, ON, Canada.
    Background: Posttransplant hyperglycemia is an important predictor of new-onset diabetes after transplantation, and both are associated with significant morbidity and mortality. Precise estimates of posttransplant hyperglycemia and diabetes in children are unknown. Low magnesium and potassium levels may also lead to diabetes after transplantation, with limited evidence in children. Read More

    Comparison between serum magnesium levels of asphyxiated neonates and normal cases.
    Med J Islam Repub Iran 2017 9;31:19. Epub 2017 Mar 9.
    Ali-Asghar Children's Hospital, Iran University of Medical Science, Tehran, Iran.
    Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magnesium in neonates with and without asphyxia. Read More

    A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8147
    aDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University bDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
    Rationale: Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

    Patient Concerns: A 62-year-old woman with short-bowel syndrome related with multiple resections of small intestines due to Crohn disease received regular intravenous administration of saccharated ferric oxide. Read More

    Durable complete remission following anti-EGFR antibodies in recurrent metastatic colorectal cancer.
    J Oncol Pharm Pract 2017 Jan 1:1078155217730130. Epub 2017 Jan 1.
    4 Department of Pharmacy, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
    In this case report, we describe a patient who remains in complete remission two years after the discontinuation of anti-EGFR monotherapy as a third-line treatment, accompanied by persistent severe hypomagnesemia. A 45-year-old Caucasian woman with mCRC started chemotherapy with weekly cetuximab. After ten months of treatment, the therapy was stopped because the patient had persistent grade III hypomagnesemia despite amiloride, oral, and intravenous magnesium. Read More

    Effect of Magnesium Supplement on Pregnancy Outcomes: A Randomized Control Trial.
    Adv Biomed Res 2017 31;6:109. Epub 2017 Aug 31.
    Department of Obstetrics and Gynecology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Magnesium (Mg) is an essential mineral required to regulate body temperature, nucleic acid, and protein synthesis with an important role in maintaining nerve and muscle cell electrical potentials. It may reduce fetal growth restriction and preeclampsia as well as increase birth weight. This study aimed to assess the effects of consuming Mg supplementation during pregnancy on pregnancy outcomes. Read More

    Hypertension and cardiac arrhythmias: a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).
    Europace 2017 Jun;19(6):891-911
    University of Wisconsin, Clinical Science Center, Madison, USA.
    Hypertension is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease, stroke, peripheral artery disease and chronic renal insufficiency. Hypertensive heart disease can manifest as many cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in hypertensive patients, especially in those with left ventricular hypertrophy (LVH) or HF. Read More

    [Expert consensus for the diagnosis and treatment of patients with Gitelman syndrome].
    • Authors:
    Zhonghua Nei Ke Za Zhi 2017 Sep;56(9):712-716
    Gitelman syndrome (GS) is an autosomal recessive, salt-losing tubulopathy caused by inactivating mutations in the123 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is characterized by hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. GS is one of the most common inherited renal tubulopathy with a prevalence estimated at about one to ten per 40 000 people. Read More

    Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial.
    Ann Transplant 2017 Aug 29;22:524-531. Epub 2017 Aug 29.
    Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
    BACKGROUND Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and in transplant recipients. We aimed to assess whether magnesium improves insulin secretion and glycemic control after transplantation in prevalent hypomagnesemic kidney transplant recipients. Read More

    Inherited, not acquired, Gitelman syndrome in a patient with Sjögren's syndrome: importance of genetic testing to distinguish the two forms.
    CEN Case Rep 2017 Nov 17;6(2):180-184. Epub 2017 Aug 17.
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Gitelman syndrome (GS) is an autosomal recessive, salt-losing renal tubulopathy caused by mutations in the SLC12A3 gene; however, it can also be acquired in patients with autoimmune disease, especially in those with Sjögren's syndrome. Differentiating between the inherited and acquired forms of GS is clinically difficult. We report a case of inherited, not acquired, GS in a patient with Sjögren's syndrome. Read More

    Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.
    Cell Commun Signal 2017 Aug 15;15(1):30. Epub 2017 Aug 15.
    Center for Biomedical Research, The Queen's Medical Center, John A. Burns School of Medicine, University of Hawaii, 1301 Punchbowl St., Honolulu, HI, 96813, USA.
    Background: Magnesium (Mg) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mghomeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. Read More

    Proton Pump Inhibitors: More Indigestion than Relief?
    Indian J Nephrol 2017 Jul-Aug;27(4):249-257
    Department of Medicine, Division of Nephrology, The Ottawa Hospital, Ottawa, Canada.
    Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also been recently reported. Read More

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