2,860 results match your criteria Hypomagnesemia


Digenetic inheritance of SLC12A3 and CLCNKB genes in a Chinese girl with Gitelman syndrome.

BMC Pediatr 2019 Apr 18;19(1):114. Epub 2019 Apr 18.

The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Background: Gitelman syndrome (GS) is an autosomal recessive disorder and mild variant of classic Bartter syndrome. The latter is caused by defects in the genes CLCNKB and/or CLCNKA (chloride voltage-gated channel Ka and Kb). Patients with GS usually have loss-of-function mutations in SLC12A3. Read More

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http://dx.doi.org/10.1186/s12887-019-1498-3DOI Listing
April 2019
2 Reads

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing
April 2019
1 Read

Magnesium: The Forgotten Electrolyte-A Review on Hypomagnesemia.

Med Sci (Basel) 2019 Apr 4;7(4). Epub 2019 Apr 4.

USA.

Magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. It plays an important role in different organ systems at the cellular and enzymatic levels. Despite its importance, it still has not received the needed attention either in the medical literature or in clinical practice in comparison to other electrolytes like sodium, potassium, and calcium. Read More

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https://www.mdpi.com/2076-3271/7/4/56
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http://dx.doi.org/10.3390/medsci7040056DOI Listing
April 2019
1 Read

Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients.

Int Urol Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Division of Nephrology, Ichiyokai Harada Hospital, 7-10 Kairoyama-cho, Saeki-ku, Hiroshima, 731-5134, Japan.

Purpose: It is unclear whether hypomagnesemia is an independent risk factor or innocent bystander for mortality in maintenance hemodialysis (MHD) patients. Thus, we studied associations between hypomagnesemia and all-cause as well as cardiovascular (CV) mortality in MHD patients.

Methods: Baseline clinical characteristics and coronary artery calcium score (CACS) of 353 Japanese MHD patients were reviewed. Read More

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http://dx.doi.org/10.1007/s11255-019-02073-wDOI Listing
April 2019
1 Read

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review.

Molecules 2019 Apr 7;24(7). Epub 2019 Apr 7.

Chair and Department of Anatomy, Medical University of Lublin, 20-090 Lublin, Poland.

The aim of this paper was to review recent literature (from 2000 onwards) and summarize the newest findings on fluctuations in the concentration of some essential macro- and microelements in those patients with a history of chronic alcohol abuse. The focus was mainly on four elements which the authors found of particular interest: Iron, magnesium, copper, and manganese. After independently reviewing over 50 articles, the results were consistent with regard to iron and magnesium. Read More

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http://dx.doi.org/10.3390/molecules24071361DOI Listing
April 2019
1 Read

Serum Magnesium Levels and Mortality in Japanese Maintenance Hemodialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,

Background/aims: Although hypomagnesemia was found to be a risk for cardiovascular diseases in the general population, the relationship between serum magnesium (Mg) levels and prognosis of patients on maintenance hemodialysis (MHD) has not been extensively studied. This study sought to determine the relationship of serum Mg levels with aortic arch calcification (AoAC) and mortality in Japanese MHD patients.

Methods: We measured serum Mg levels in a cohort of 392 patients on MHD, classified the patients into 3 groups according to these levels, and followed their course for 4 years. Read More

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http://dx.doi.org/10.1159/000496659DOI Listing
April 2019
15 Reads

Hypomagnesemia and Survival in Patients with Ovarian Cancer Who Received Chemotherapy with Carboplatin.

Oncologist 2019 Apr 2. Epub 2019 Apr 2.

Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Hypomagnesemia is a known side effect of several antineoplastic agents, but its impact on outcomes of patients with cancer is not well understood. We examined whether magnesium abnormalities affect survival in patients with ovarian cancer who receive chemotherapy containing carboplatin.

Materials And Methods: We included patients with advanced ovarian cancer who had undergone surgery and chemotherapy between January 1, 2004, and December 31, 2014, at our institution. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0465DOI Listing
April 2019
4 Reads
4.865 Impact Factor

Acquired Gitelman Syndrome Associated with Systemic Sclerosis.

Cureus 2019 Jan 20;11(1):e3923. Epub 2019 Jan 20.

Internal Medicine, Einstein Medical Center, Philadelphia, USA.

Gitelman syndrome is an inherited renal disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria and metabolic alkalosis linked to the genes encoding the thiazide sensitive NaCl cotransporter (NCCT) located on the distal convoluted tubule of the kidney. It usually presents in late childhood or early adulthood with electrolyte abnormalities resembling chronic thiazide diuretic use. Acquired Gitelman syndrome is a very rare disorder mostly associated with Sjogren's syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430306PMC
January 2019
4 Reads

Does the use of proton pump inhibitors increase the risk of hypomagnesemia: An updated systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(13):e15011

Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing.

Background: Proton pump inhibitors (PPIs) are commonly used in the treatment of acid-related diseases; however, the association between the use of PPIs and potential risk of hypomagnesemia is controversial.

Methods: In the present study, databases including PubMed, EMBASE, MEDLINE, PsycINFO, CINAHL, the Cochrane Library, and 4 Chinese databases were searched since the inception until April 2018. Previous observational studies on the incidence of hypomagnesemia in individuals exposed to PPIs were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000015011DOI Listing
March 2019
4 Reads

Serum PTH reference values in an adult Brazilian population: implications for the diagnosis of hyperparathyroidism.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: To define serum parathyroid hormone (PTH) reference values in carefully selected subjects following the recommended pre-analytical guidelines.

Subjects And Methods: First, 676 adults who would be submitted to thyroidectomy were evaluated. Patients using interfering medications or with malabsorption syndrome, hypomagnesemia, hyper- or hypophosphatemia, hypo- or hypercalcemia, 25-hydroxyvitamin D < 30 ng/dL, estimated glomerular filtration rate < 60 mL/min/1. Read More

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http://dx.doi.org/10.20945/2359-3997000000117DOI Listing
March 2019
1 Read

A pediatric case of hypomagnesemia 1 (HOMG1) caused by novel compound heterozygous mutations in .

Hum Genome Var 2019 6;6:13. Epub 2019 Mar 6.

Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Kyoto, Japan.

Hypomagnesemia 1 (HOMG1) is an extremely rare disease with autosomal recessive inheritance that is caused by mutations in the transient receptor potential melastatin 6 gene (). Here, we describe a pediatric HOMG1 case with novel compound heterozygous mutations of (c.1483 C > T [p. Read More

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http://dx.doi.org/10.1038/s41439-019-0043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403217PMC
March 2019
1 Read

Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions.

Pediatr Nephrol 2019 Mar 22. Epub 2019 Mar 22.

Faculty of Medicine, Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Hypomagnesemia with secondary hypocalcemia is a rare autosomal recessive disorder which manifests in early infancy with generalized seizures, other symptoms of neuromuscular irritability, and growth disturbances. Homozygous mutations in the magnesium transporter gene, transient receptor potential melastatin 6 (TRPM6), cause the disease. Here, we present an 8-month-old Turkish boy with a novel mutation of TRPM6. Read More

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http://dx.doi.org/10.1007/s00467-019-04231-9DOI Listing
March 2019
4 Reads

Cyclosporine A trough concentrations are associated with acute GvHD after non-myeloablative allogeneic hematopoietic cell transplantation.

PLoS One 2019 21;14(3):e0213913. Epub 2019 Mar 21.

Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.

Low plasma CsA concentrations (<300-350 ng/mL) early following allogeneic hematopoietic stem cell transplantation (HSCT) is associated with an increased risk of developing acute graft-versus-host disease (aGvHD). Nevertheless, the current optimal target trough concentration for CsA following HSCT is considered to be 200-400 ng/mL. Here, we performed a retrospective analysis of a homogeneous group of 129 patients who received HSCT after non-myeloablative conditioning, and we analyzed the impact of CsA trough concentration measured during the first four weeks (CsA W1-4) on the incidence aGvHD, relapse-free survival (RFS), non-relapse mortality (NRM), overall survival (OS), and toxicity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213913PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428294PMC
March 2019
2 Reads

Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.

J Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China.

Background: Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive.

Methods: Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL). Read More

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http://dx.doi.org/10.1007/s40620-019-00601-6DOI Listing
March 2019
2 Reads

Gitelman Syndrome: A Rare Cause of Seizure Disorder and a Systematic Review.

Case Rep Med 2019 5;2019:4204907. Epub 2019 Feb 5.

Resident Physician, Abington Hospital-Jefferson Health, Abington, PA, USA.

Gitelman syndrome is one of the few inherited causes of metabolic alkalosis due to salt losing tubulopathy. It is caused by tubular defects at the level of distal convoluted tubules, mimicking a thiazide-like tumor. It usually presents in late childhood or in teenage as nonspecific weakness, fatigability, polyuria, and polydipsia but very rarely with seizures. Read More

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http://dx.doi.org/10.1155/2019/4204907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379858PMC
February 2019
1 Read

Hypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma.

Caspian J Intern Med 2019 ;10(1):111-117

Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain.

Background: Enteropathy-associated T-cell lymphoma (EATL) is a rare and aggressive type of extranodal T-cell lymphoma (TCL) arising in the gastrointestinal (GI) tract and represents 5-8% of all T-cell non-Hodgkin lymphomas (NHL) and 10-25% of primary intestinal lymphomas.

Case Presentation: We reported a 78-year-old woman presenting with severe hypocalcemia. Investigations confirmed vitamin D and iron deficiency as well as hypoalbuminemia. Read More

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http://dx.doi.org/10.22088/cjim.10.1.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386331PMC
January 2019
5 Reads

Renal phospholipidosis and impaired magnesium handling in high-fat-diet-fed mice.

FASEB J 2019 Mar 8:fj201801778RR. Epub 2019 Mar 8.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Hypomagnesemia (blood Mg concentration <0.7 mM) is a common electrolyte disorder in patients with type 2 diabetes (T2D), but the etiology remains largely unknown. In patients with T2D, reduced blood Mg levels are associated with an increased decline in renal function, independent of glycemic control and hypertension. Read More

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http://dx.doi.org/10.1096/fj.201801778RRDOI Listing
March 2019
3 Reads
5.043 Impact Factor

Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators.

Int J Mol Sci 2019 Mar 6;20(5). Epub 2019 Mar 6.

Center for Cooperative Research in Biosciences (CIC bioGUNE), Bizkaia Science and Technology Park Bld 800, 48160 Derio, Bizkaia, Spain.

The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. Read More

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http://dx.doi.org/10.3390/ijms20051135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429129PMC
March 2019
2 Reads

Low serum magnesium is associated with faster decline in kidney function: the Dallas Heart Study experience.

J Investig Med 2019 Mar 2. Epub 2019 Mar 2.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, Dallas, TX, USA.

Hypomagnesemia associates with inflammation and risk of diabetes and hypertension, which may contribute to kidney function decline. We hypothesized that low serum magnesium (SMg) levels independently associate with a significant decline in estimated glomerular filtration rate (eGFR). We analyzed SMg levels in 2056 participants from the Dallas Heart Study, a longitudinal, population-based, multiethnic, cohort study involving residents of Dallas County, Texas, USA. Read More

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http://dx.doi.org/10.1136/jim-2018-000966DOI Listing
March 2019
1 Read

Familial Hypomagnesemia, Hypercalciuria and Nephrocalcinosis with Novel Mutation.

Indian J Nephrol 2019 Jan-Feb;29(1):57-61

Department of Nephrology, Apollo Hospitals, Chennai, Tamil Nadu, India.

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder that is caused by mutation in genes coding for tight junction proteins claudin-16 and claudin-19. It is characterized by renal wasting of magnesium and calcium associated with the development of nephrocalcinosis and renal stones by early childhood. Most of them progress to end-stage renal failure by the second or third decade. Read More

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http://www.indianjnephrol.org/preprintarticle.asp?id=248822
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http://dx.doi.org/10.4103/ijn.IJN_323_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375017PMC
March 2019
6 Reads

Hypophosphatemia before endoscopic gastrostomy predicts higher mortality during the first week and first month post-gastrostomy: a risk marker of refeeding syndrome in gastrostomy-fed patients.

Nutr Hosp 2019 Apr;36(2):247-252

Gastroenterology Department. GENE - Artificial Feeding Team. Hospital Garcia de Orta.

Introduction: Introduction: starvation is usual in patients referred for endoscopic gastrostomy (PEG). A high risk of refeeding syndrome (RS) may contribute to poor prognosis. Objectives: this study aims to: a) evaluate serum phosphorus and magnesium when patients underwent PEG; b) determine the mortality rate during the first week and first month of enteral nutrition; and c) assess if hypophosphatemia or hypomagnesemia are associated with early mortality. Read More

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http://dx.doi.org/10.20960/nh.2251DOI Listing
April 2019
1 Read

Three cases of transient neonatal pseudohypoparathyroidism.

Sudan J Paediatr 2018 ;18(2):42-47

Department of Clinical Biochemistry, Klatovy Hospital, Klatovy, Czech Republic.

Neonatal hypocalcemia is defined as serum calcium (S-Ca) < 2.0 mmol/l in full-term newborns and <1.75 mmol/l in preterm newborns. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=289314
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http://dx.doi.org/10.24911/SJP.106-1516889879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378568PMC
January 2018
8 Reads

The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia in a National Cohort of Veteran Patients with HIV.

J Int Assoc Provid AIDS Care 2019 Jan-Dec;18:2325958218821652

4 Biostatistics Division, Department of Epidemiology & Biostatistics, University of South Carolina, Columbia, SC, USA.

Objectives:: To examine the risk of hypomagnesemia of HIV-positive patients adherent to proton pump inhibitors (PPIs).

Methods:: A cohort study utilizing the Veterans Affairs Informatics and Computing Infrastructure was conducted on patients with (1) a complete antiretroviral therapy, (2) a serum magnesium measure during the study period, and (3) adherent to PPIs. Statistical analyses evaluated baseline characteristics between cohorts and a Cox proportional hazards model evaluating the association of hypomagnesemia while adjusting for baseline covariates. Read More

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http://dx.doi.org/10.1177/2325958218821652DOI Listing
February 2019
1 Read

Gitelman syndrome presenting with cerebellar ataxia: a case report.

Acta Neurol Belg 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, School of Medicine, Izmir, Turkey.

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http://dx.doi.org/10.1007/s13760-019-01095-6DOI Listing
February 2019
1 Read

Electrolyte Disorders as Triggers for Takotsubo Cardiomyopathy.

Eur J Case Rep Intern Med 2018 24;5(4):000760. Epub 2018 Apr 24.

Internal Medicine Department, Brugmann University Hospital, Brussels, Belgium.

A 56-year-old woman presented with cognitive impairment, confusion and slowed speech, muscle cramps and peripheral paraesthesia preceded by vomiting. Blood tests revealed severe hypokalaemia, hyponatremia, hypomagnesemia and hypocalcaemia. Following a diagnosis of Takotsubo cardiomyopathy based on ultrasonography, the patient was treated with electrolyte supplementation and recovered within 48h. Read More

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http://dx.doi.org/10.12890/2018_000760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346755PMC
April 2018
1 Read

Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice.

Sci Rep 2019 Feb 11;9(1):1770. Epub 2019 Feb 11.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg) concentration <0.7 mmol/L). In T2D patients, treatment with metformin is associated with reduced blood Mg levels. Read More

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http://dx.doi.org/10.1038/s41598-018-38351-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370757PMC
February 2019
6 Reads

Doxorubicin Loaded Magnesium Oxide Nanoflakes as pH Dependent Carriers for Simultaneous Treatment of Cancer and Hypomagnesemia.

Nanomaterials (Basel) 2019 Feb 6;9(2). Epub 2019 Feb 6.

Department of Chemistry and Biochemistry, The University of Mississippi, University, MS 38677, USA.

Doxorubicin (DOX) is an anticancer drug commonly used in treating cancer; however, it has severe cytotoxicity effects. To overcome both the adverse effects of the drug and mineral deficiency (i.e. Read More

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http://dx.doi.org/10.3390/nano9020208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409820PMC
February 2019
2 Reads

Magnesium in addiction - a general view.

Authors:
Mihai Nechifor

Magnes Res 2018 Aug;31(3):90-98

Department of Pharmacology "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Addiction is a dysregulation of brain reward systems that progressively increases, resulting in compulsive drug use and loss of control over drug-taking. Addiction is a brain disease. There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine, alcohol, caffeine, and others). Read More

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http://dx.doi.org/10.1684/mrh.2018.0443DOI Listing
August 2018
7 Reads

The role of magnesium and zinc in depression: similarities and differences.

Magnes Res 2018 Aug;31(3):78-89

Laboratory of Trace Elements Neurobiology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland, Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688, Kraków, Poland.

Antidepressant therapy exhibits low clinical efficacy and produces a variety of unwanted side effects. Therefore, the search for more effective antidepressants is still in progress. Antidepressant properties of magnesium and zinc have been demonstrated in animal screen tests/models and clinical studies. Read More

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http://dx.doi.org/10.1684/mrh.2018.0442DOI Listing
August 2018
2 Reads

Clearance of Magnesium in Peritoneal Dialysis Patients: A Single-Center Study.

Blood Purif 2019 30;47 Suppl 1:1-7. Epub 2019 Jan 30.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This retrospective study aimed to investigate the clearance of magnesium (Mg) in peritoneal dialysis (PD) patients and its influencing factors.

Methods: The demographic information, clinical characteristics and laboratory data of the patients were collected. According to the corrected serum Mg (cS-Mg) concentration, patients were divided into 3 groups including hypomagnesemia (Mg2+ < 0. Read More

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http://dx.doi.org/10.1159/000496217DOI Listing
January 2019
2 Reads

Effects of diabetic ketoacidosis in the respiratory system.

World J Diabetes 2019 Jan;10(1):16-22

Division of Pulmonary, Critical Care and Sleep Medicine, Texas A and M University, Corpus Christy, TX 78412, United States.

Diabetes affects approximately 30 million persons in the United States. Diabetes ketoacidosis is one of the most serious and acute complications of diabetes. At the time of presentation and during treatment of diabetic ketoacidosis (DKA), several metabolic and electrolyte derangements can ultimately result in respiratory compromise. Read More

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http://dx.doi.org/10.4239/wjd.v10.i1.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347653PMC
January 2019
3 Reads

Total serum magnesium in cats with chronic kidney disease with nephrolithiasis.

J Feline Med Surg 2019 Jan 29:1098612X18823588. Epub 2019 Jan 29.

Internal Medicine, School of Veterinary Medicine and Animal Science/University of Sao Paulo, Sao Paulo, Brazil.

Objectives: Magnesium has been 'the forgotten ion' for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. Read More

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http://dx.doi.org/10.1177/1098612X18823588DOI Listing
January 2019
3 Reads

Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects.

Exp Cell Res 2019 Mar 25;376(2):210-220. Epub 2019 Jan 25.

Department of Oral Science, Graduate School of Medicine, Chiba University, 1-8- 1 Inohana, Chuo-ku, Chiba 260-8670, Japan; Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.

Cetuximab, an inhibitor of the epidermal growth factor receptor that is used widely to treat human cancers including oral squamous cell carcinoma (OSCC), has characteristic side effects of skin rash and hypomagnesemia. However, the mechanisms of and therapeutic agents for skin rashes and hypomagnesemia are still poorly understood. Our gene expression profiling analyses showed that cetuximab activates the p38 MAPK pathways in human skin cells (human keratinocyte cell line [HaCaT]) and inhibits c-Fos-related signals in human embryonic kidney cells (HEK293). Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.01.016DOI Listing

HNF1B nephropathy has a slow-progressive phenotype in childhood-with the exception of very early onset cases: results of the German Multicenter HNF1B Childhood Registry.

Pediatr Nephrol 2019 Jun 21;34(6):1065-1075. Epub 2019 Jan 21.

Pediatric Nephrology, University Children's Hospital Marburg, Baldingerstrasse 1, 35033, Marburg, Germany.

Background: HNF1B gene mutations are an important cause of bilateral (cystic) dysplasia in children, complicated by chronic renal insufficiency. The clinical variability, the absence of genotype-phenotype correlations, and limited long-term data render counseling of affected families difficult.

Methods: Longitudinal data of 62 children probands with genetically proven HNF1B nephropathy was obtained in a multicenter approach. Read More

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http://dx.doi.org/10.1007/s00467-018-4188-8DOI Listing
June 2019
23 Reads

Influence of oral magnesium-containing supplement and antacid administration on hypomagnesemia induced by panitumumab.

Cancer Chemother Pharmacol 2019 Apr 19;83(4):673-679. Epub 2019 Jan 19.

Department of Pharmacy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka Prefecture, 411-8777, Japan.

Purpose: Hypomagnesemia is a common side effect of panitumumab. The effect of magnesium-containing supplement as a laxative and concomitant antacid (proton pump inhibitor and histamine H antagonist) administration on panitumumab-induced hypomagnesemia was retrospectively investigated.

Methods: Patients with advanced or recurrent colorectal cancer who received panitumumab were included in this study. Read More

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http://dx.doi.org/10.1007/s00280-019-03772-yDOI Listing
April 2019
4 Reads

Phenotypic differences and similarities of monozygotic twins with maturity-onset diabetes of the young type 5.

J Diabetes Investig 2019 Jan 13. Epub 2019 Jan 13.

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Here, we report phenotypic differences and similarities of monozygotic twins with maturity-onset diabetes of the young type 5 harboring a partial deletion of chromosome 17q12. The proband and her twin sister manifested complete aplasia and marked hypoplasia, respectively, of the body and tail of the pancreas. Whereas both twins showed marked hypoplasia of the right kidney and multiple cysts in both kidneys, only the proband's sister showed hydronephrosis in the left kidney. Read More

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http://dx.doi.org/10.1111/jdi.13004DOI Listing
January 2019
2 Reads

Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review.

Case Rep Med 2018 29;2018:1980638. Epub 2018 Nov 29.

Department of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, Germany.

Background: Hypomagnesemia can cause various unspecific neurological complications, which can lead to diagnostic confusion. One of these complications is the posterior reversible encephalopathy syndrome (PRES), which is extremely uncommon and has been reported only twice in the English-language literature.

Case Presentation: We report the case of a 60-year-old man who presented with PRES involving only the cerebellar hemispheres and associated with hypomagnesemia. Read More

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https://www.hindawi.com/journals/crim/2018/1980638/
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http://dx.doi.org/10.1155/2018/1980638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304829PMC
November 2018
17 Reads

Perioperative magnesium levels in total thyroidectomy and relationship to hypocalcemia.

Head Neck 2019 Jan 10. Epub 2019 Jan 10.

Department of Otolaryngology - Head & Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.

Background: We have previously shown an association between hypomagnesemia and hypocalcemia after thyroidectomy. However, little is known regarding the trend in magnesium levels in the days after thyroidectomy. Our objective was to study this trend in magnesium levels after thyroidectomy. Read More

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http://dx.doi.org/10.1002/hed.25644DOI Listing
January 2019
10 Reads

Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, Minnesota.

In heart failure and type 2 diabetes mellitus (DM), the majority of patients have hypomagnesemia, and magnesium (Mg) supplementation has improved cardiac function and insulin resistance. Recently, we have shown that DM can cause cardiac diastolic dysfunction (DD). Therefore, we hypothesized that Mg supplementation would improve diastolic function in DM. Read More

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https://insight.jci.org/articles/view/123182
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http://dx.doi.org/10.1172/jci.insight.123182DOI Listing
January 2019
24 Reads

Subacute Gummy Vitamin Overdose as a Rare Manifestation of Child Neglect.

Pediatr Emerg Care 2019 Jan 7. Epub 2019 Jan 7.

We present a case of a 20-month-old girl who presented to the emergency department with anorexia, progressive weakness, and lethargy who was found to have severe hypercalcemia (20.7 mg/dL) and vitamin D hypervitaminosis. Further questioning revealed that this was secondary to a subacute toxic ingestion of "L'il Critters" calcium and vitamin D3 gummy vitamins that were being administered by the patient's mother multiple times a day for several weeks or even months. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001718DOI Listing
January 2019
15 Reads

Exonic CLDN16 mutations associated with familial hypomagnesemia with hypercalciuria and nephrocalcinosis can induce deleterious mRNA alterations.

BMC Med Genet 2019 Jan 8;20(1). Epub 2019 Jan 8.

Unidad de Investigación, Hospital Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010, Santa Cruz de Tenerife, Spain.

Background: Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis type 1 is an autosomal recessive disease characterized by excessive renal magnesium and calcium excretion, bilateral nephrocalcinosis, and progressive chronic renal failure. This rare disease is caused by mutations in CLDN16 that encodes claudin-16, a tight-junction protein involved in paracellular reabsorption of magnesium and calcium in the renal tubule. Most of these variants are located in exons and have been classified as missense mutations. Read More

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http://dx.doi.org/10.1186/s12881-018-0713-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325764PMC
January 2019
3 Reads

Clinical and Genetic Characteristics in Patients With Gitelman Syndrome.

Kidney Int Rep 2019 Jan 28;4(1):119-125. Epub 2018 Sep 28.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Introduction: Gitelman syndrome (GS) is a tubulopathy exhibited by salt loss. GS cases are most often diagnosed by chance blood test. Aside from that, some cases are also diagnosed from tetanic symptoms associated with hypokalemia and/or hypomagnesemia or short stature. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308995PMC
January 2019
6 Reads

The association between serum magnesium levels and community-acquired pneumonia 30-day mortality.

BMC Infect Dis 2018 Dec 27;18(1):698. Epub 2018 Dec 27.

The Rappaport's Faculty of Medicine, The Technion Institute, Haifa, Israel.

Background: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. Read More

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http://dx.doi.org/10.1186/s12879-018-3627-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307202PMC
December 2018
3 Reads

Pathogenesis and treatment of electrolyte problems post transplant.

Authors:
Erin Kim

Curr Opin Pediatr 2019 Apr;31(2):213-218

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Purpose Of Review: Electrolyte abnormalities posttransplant are common occurrences that can have significant short-term and long-term effects on graft outcome and patient quality of life. Understanding the pathophysiology of these electrolyte derangements can help guide management to optimize bone health and minimize cardiovascular disease. This review explores the pathogenesis of the most common postrenal transplant electrolytes abnormalities as well as current treatment options. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000715DOI Listing
April 2019
4 Reads

Recurrent seizure-triggered Takotsubo associated with hypokalemia and hypomagnesemia.

Authors:
Josef Finsterer

Seizure 2019 Feb 4;65:176. Epub 2018 Dec 4.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vterinary University of Vienna, Postfach 20, 1180, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.12.001DOI Listing
February 2019
4 Reads

Drug use is associated with lower plasma magnesium levels in geriatric outpatients; possible clinical relevance.

Clin Nutr 2018 Dec 6. Epub 2018 Dec 6.

Division of Human Nutrition and Health, Wageningen University and Research Centre, P.O. Box 17, 6700 AA Wageningen, the Netherlands; Nutrition & Healthcare Alliance, Willy Brandtlaan 10, 6716 RP Ede, the Netherlands. Electronic address:

Background: Hypomagnesemia has been associated with diabetes, cardiovascular disease, and other disorders. Drug use has been suggested as one of the risk factors for low magnesium (Mg) levels. In the elderly population, prone to polypharmacy and inadequate Mg intake, hypomagnesemia might be relevant. Read More

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http://dx.doi.org/10.1016/j.clnu.2018.11.018DOI Listing
December 2018
6 Reads
4.476 Impact Factor

Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

Gene 2019 Mar 18;689:227-234. Epub 2018 Dec 18.

Unidad de Investigacion, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. Electronic address:

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal-recessive renal tubular disorder characterized by excessive urinary losses of magnesium and calcium, bilateral nephrocalcinosis and progressive chronic renal failure in childhood or adolescence. The disease is caused by mutations in the tight-junction proteins claudin-16 and claudin-19 that are encoded by the CLDN16 and CLDN19 genes, respectively. Patients with CLDN19 mutations also are affected with severe ocular abnormalities. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.024DOI Listing
March 2019
3 Reads

Meta-analysis of the effects of anti-epidermal growth factor receptor on recurrent/metastatic head and neck squamous cell carcinoma.

Medicine (Baltimore) 2018 Dec;97(51):e13717

Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou.

Background: We performed a meta-analysis to compare the efficacy and safety of anti-epidermal growth factor receptor (EGFR) therapy and non-anti-EGFR therapy in recurrent/metastatic (RM) head and neck squamous cell carcinoma (HNSCC).

Methods: The Cochrane library, WanFang Data, PubMed, Medline, VIP, CBM, and EBSCO databases were searched for relevant studies. The objective response rate (ORR, defined as complete response or partial response according to RECTST version 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000013717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320165PMC
December 2018
3 Reads

A novel SLC12A3 homozygous c2039delG mutation in Gitelman syndrome with hypocalcemia.

BMC Nephrol 2018 Dec 17;19(1):362. Epub 2018 Dec 17.

The Endocrinology Department of the Third Xiangya Hospital, Central South University, Tongzipo Road, Changsha, 410013, China.

Background: Gitelman syndrome (GS) is a rare autosomal recessive renal tubular disease, caused by mutations in the SLC12A3 gene, which encodes the renal thiazide-sensitive Na/Cl cotransporter (NCCT) in the distal renal tubule.

Case Presentation: A 23-year-old woman was admitted with limb numbness, recurrent tetany and palpitation. Laboratory tests showed hypokalemic alkalosis, hypomagnesemia, hypocalcemia and secondary hyperaldosteronism, as well as hypocalciuria and transient decreased PTH. Read More

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http://dx.doi.org/10.1186/s12882-018-1163-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296056PMC
December 2018
3 Reads