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    Experiences with Continuous Venovenous Hemofiltration using 18mmol/L predilution Citrate anticoagulation and a Phosphate Containing Replacement Solution.
    Indian J Crit Care Med 2017 Jan;21(1):11-16
    Department of Intensive Care, Intensive Care Unit, Queen Elizabeth Hospital, Kowloon, Hong Kong.
    Context: Regional citrate anticoagulation for continuous renal replacement therapy is associated with a longer filter-life, less bleeding events and improved mortality. Problems associated with using Prismocitrate 10/2 solution in continuous renal replacement therapy, include hypomagnesemia, hypophosphatemia and the need for additional bicarbonate infusion.

    Aims: This study uses the new Prismocitrate 18/0 solution for improved buffer balance and Phoxilium solution for a more favourable electrolyte profile. Read More

    Neurologic manifestations of major electrolyte abnormalities.
    Handb Clin Neurol 2017 ;141:705-713
    Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:
    The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    [Review: UPDATE on magnesium metabolism].
    G Ital Nefrol 2016 Nov-Dec;33(6)
    Magnesium is the second intracellular cation and the fourth most abundant mineral in the body. Low levels of magnesium have been associated with insulin resistance and type-2 diabetes mellitus, asthma, osteoporosis and chronic kidney disease (CKD). The use of proton pump inhibitors (PPIs) represents the most common cause of hypomagnesemia. Read More

    [Gitelman´s syndrome as common cause of hypokalemia and hypomagnesemia].
    Vnitr Lek 2016 ;62(Supplementum 6):78-83
    The Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis and presence of hypocalciuria and hypomagnesemia. It is one of the most common congenital "salt-wasting" tubulo-pathies, where the impairment of function of the Na+-Cl- cotransporter (NCCT) in the distal convoluted tubule is primary and hypokalemia secondary. Hypomagnesemia is caused by the impairment of magnesium reabsorption through TRPM6 channel which is located just by NCCT. Read More

    Systematic Review and Meta-Analysis of Patiromer and Sodium Zirconium Cyclosilicate: A New Armamentarium for the Treatment of Hyperkalemia.
    Pharmacotherapy 2017 Jan 25. Epub 2017 Jan 25.
    Department of Biostatistics, School of Public Health and Health Professions, University at Buffalo.
    Objective: To compare and contrast the efficacy and safety of patiromer and sodium zirconium cyclosilicate (ZS-9) in the treatment of hyperkalemia.

    Design: A systematic review and meta-analysis of phase II and III clinical trial data was completed.

    Patients Or Participants: Eight studies (2 phase II and 4 phase III trials with 2 subgroup analyses) were included in the qualitative analysis whereas six studies (2 phase II and 4 phase III trials) were included in the meta-analysis. Read More

    A case of chronic hypomagnesemia in a cancer survivor.
    Hosp Pract (1995) 2017 Feb 6:1-7. Epub 2017 Feb 6.
    a Hospital Medicine Unit, Massachusetts General Hospital , Boston , MA , USA ​​.
    Objectives: Hypomagnesemia is common among hospitalized patients, particularly those who are critically ill. It can be associated with a number of potentially life-threatening cardiovascular, neurological and behavioral manifestations. As opposed to acute, chronic hypomagnesemia is often underdiagnosed and underreported and as such may pose a diagnostic and therapeutic problem. Read More

    Proton pump inhibitor use for 12 months is not associated with changes in serum magnesium levels: a prospective open label comparative study.
    Turk J Gastroenterol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Pharmacology, Prishtina University School of Medicine, Prishtina, Kosovo.
    Background/aims: Proton pump inhibitors (PPIs) are a widely used class of drugs because of a generally acceptable safety profile. Among recently raised safety issues of the long-term use of PPIs is the increased risk of developing hypomagnesemia. As there have been very few prospective studies measuring serum magnesium levels before and after PPI therapy, we aimed to prospectively assess the potential association between PPI therapy for 12 months and the risk of hypomagnesemia as well as the incidence of new-onset hypomagnesemia during the study. Read More

    Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review.
    Int J Physiol Pathophysiol Pharmacol 2016 25;8(4):169-174. Epub 2016 Dec 25.
    Discipline of Medicine, The University of Adelaide, Royal Adelaide Hospital Adelaide, South Australia 5000, Australia.
    Proton pump inhibitor (PPI)-induced hypomagnesaemia is a rare but serious adverse effect of a widely prescribed medication. It has become an increasingly recognised complication since 2006, with the U.S. Read More

    Renal Infiltration by Diffuse Large B-Cell Lymphoma as a Rare Cause of Fanconi's Syndrome: A Case Report.
    Cureus 2016 Nov 30;8(11):e904. Epub 2016 Nov 30.
    Histopathology, Shifa International Hospital, Islamabad, Pakistan.
    We report the case of a 16-year-old female patient with a known history of coeliac disease, who presented with the complaints of diarrhea, vomiting and generalized body weakness. On examination, she was found to have dehydration, decreased power in all her limbs, cervical lymphadenopathy and hepatosplenomegaly. Investigations showed severe hypokalemia, hyponatremia, hypomagnesemia, hypoglycemia and mildly enlarged kidneys on ultrasonography. Read More

    Outcomes of an inpatient refeeding protocol in youth with anorexia nervosa: Rady Children's Hospital San Diego/University of California, San Diego.
    J Eat Disord 2017 3;5. Epub 2017 Jan 3.
    Division of Academic General Pediatrics and Community Health, Department of Pediatrics, University of California, San Diego School of Medicine and Rady Children's Hospital of San Diego, 7910 Frost Street, Suite 300, San Diego, CA 92123 USA ; 9500 Gilman Drive, MC 0874, La Jolla, CA 92093 USA.
    Background: Current guidelines for nutritional rehabilitation in hospitalized restrictive eating disorder patients recommend a cautious approach to refeeding. Several studies suggest that higher calorie diets may be safe and effective, but have traditionally excluded severely malnourished patients. The goal of this study was to evaluate the safety of a higher calorie nutritional rehabilitation protocol (NRP) in a broad sample of inpatients with restrictive eating disorders, including those who were severely malnourished. Read More

    The Incidence of Cisplatin-induced Hypomagnesemia in Cervical Cancer Patients Receiving Cisplatin Alone.
    Yakugaku Zasshi 2017 ;137(1):79-82
    Departments of Pharmacy, Aichi Medical University Hospital.
     Hypomagnesemia is one side effect in patients receiving cisplatin. However, there are few reports of cisplatin-induced hypomagnesemia in Japan. We retrospectively investigated the incidence of hypomagnesemia and nephrotoxicity in patients undergoing radiation therapy who were treated with cisplatin alone (dosage: 40 mg/m(2), administration interval: 1 week) for cervical cancer. Read More

    Bedaquiline in the multidrug-resistant tuberculosis treatment: Belarus experience.
    Int J Mycobacteriol 2016 Dec 23;5 Suppl 1:S62-S63. Epub 2016 Nov 23.
    Centre for Examinations and Tests in Health Care, Minsk, Belarus.
    Background/objective: Outcomes of treatment for multidrug-resistant tuberculosis (MDR-TB) remain poor worldwide. Among patients with MDR-TB in Belarus who started treatment in 2012, only 54% completed it successfully, with treatment failure reported in 22% of the patients; additionally, 11% died and 13% were lost to follow-up or remained unevaluated. In Belarus, to improve outcomes, bedaquiline was introduced in MDR-TB treatment in June 2015. Read More

    Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients.
    Pediatr Nephrol 2016 Dec 30. Epub 2016 Dec 30.
    Great Ormond Street Hospital for Children, London, WC1N 3JH, UK.
    Background: New-onset diabetes after transplantation (NODAT) is a significant co-morbidity following kidney transplantation. Lower post-transplant serum magnesium levels have been found to be an independent risk factor for NODAT in adult kidney transplant recipients.

    Methods: We undertook a retrospective analysis of risk factors for NODAT in pediatric renal transplant recipients at our institution with the aim of determining if hypomagnesemia confers a significant risk of developing NODAT in this patient population. Read More

    Renal function of cyclin M2 Mg2+ transporter maintains blood pressure.
    J Hypertens 2017 Mar;35(3):585-592
    Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
    Objectives: Epidemiological studies have shown that magnesium intake/excretion is inversely correlated with blood pressure (BP), and artificial supplementation of magnesium was able to prevent hypertension. However, there has been no molecular genetic study showing the importance of magnesium homeostasis in BP regulation.

    Methods: We analyzed magnesium content and BP of mice lacking genes encoding cyclin M (CNNM) Mg transporter family proteins. Read More

    A novel mutation of CLCNKB in a Korean patient of mixed phenotype of Bartter-Gitelman syndrome.
    Korean J Pediatr 2016 Nov 30;59(Suppl 1):S103-S106. Epub 2016 Nov 30.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Bartter syndrome (BS) is an inherited renal tubular disorder characterized by low or normal blood pressure, hypokalemic metabolic alkalosis, and hyperreninemic hyperaldosteronism. Type III BS is caused by loss-of-function mutations in CLCNKB encoding basolateral ClC-Kb. The clinical phenotype of patients with CLCNKB mutations has been known to be highly variable, and cases that are difficult to categorize as type III BS or other hereditary tubulopathies, such as Gitelman syndrome, have been rarely reported. Read More

    A Quick Reference on Hypocalcemia.
    Vet Clin North Am Small Anim Pract 2017 Mar 22;47(2):249-256. Epub 2016 Dec 22.
    The Ohio State University, 317 West 6th Avenue, Columbus, OH 43201, USA. Electronic address:
    Primary hypoparathyroidism should be considered in dogs with vague signs, including tremors, facial rubbing, and seizures. Ionized hypocalcemia should be considered in dogs with protein-losing enteropathy, especially lymphangiectasia caused by hypovitaminosis D. Ionized hypocalcemia typically occurs only in advanced chronic kidney disease. Read More

    Risk factors for QTc-prolongation: systematic review of the evidence.
    Int J Clin Pharm 2017 Feb 23;39(1):16-25. Epub 2016 Dec 23.
    Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, O&N2, Box 521, 3000, Leuven, Belgium.
    Background QTc-interval prolongation has been associated with serious adverse events, such as Torsade de Pointes and sudden cardiac death. In the prevention of QTc-prolongation, special attention should go to high-risk patients. Aim of the review The aim of this review is to summarize and assess the evidence for different risk factors for QTc-prolongation (demographic factors, comorbidities, electrolytes, QTc-prolonging medication). Read More

    Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
    Kidney Int 2017 Jan;91(1):24-33
    Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Centre d'Investigation Clinique, Paris, France; Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte, Paris, France.
    Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is usually detected during adolescence or adulthood, either fortuitously or in association with mild or nonspecific symptoms or both. Read More

    The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis.
    Medicine (Baltimore) 2016 Dec;95(50):e5406
    aSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok bDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Ongkharak, Nakhon Nayok cDepartment of Family Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University dCardiology Unit, Department of Pediatrics, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand eDepartment of Internal Medicine "F", Assaf Harofeh Medical Center (Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel), Zerifin, Israel fCenter for Clinical Epidemiology and Biostatistics, The School of Medicine and Public Health, the University of Newcastle, Newcastle, NSW, Australia.
    Background: Low serum magnesium (Mg) has been independently shown to increase risk of heart failure (HF), but data on the association between serum Mg concentration and the outcome of patients with HF are conflicting. The purpose of this systematic review and meta-analysis was to estimate the prognostic effects of hypermagnesemia and hypomagnesemia on cardiovascular (CV) mortality and all-cause mortality (ACM) of patients with HF.

    Methods: Relevant studies were identified from Medline and Scopus databases. Read More

    Impact of sevelamer hydrochloride on serum magnesium concentrations in hemodialysis patients.
    Magnes Res 2016 Apr;29(4):184-190
    Department of Nephrology and Dialysis, H. N. Medic, 6-1-5, Atsubetsuchuo-5, Atsubetsu-ku, Sapporo 004-0055, Hokkaido, Japan.
    Serum Mg levels are elevated in patients with renal insufficiency: harmful effects of hypomagnesemia have been reported in patients receiving hemodialysis (HD). In this cross-sectional study, which included 86 HD patients (male : female = 56:30, age 68 ± 12 years), we examined the clinical factors associated with serum Mg levels, with a focus on sevelamer, a phosphate binder widely used to control the hyperphosphatemia of HD patients. The mean serum Mg concentration among our patients was 2. Read More

    Acquired Bartter syndrome following gentamicin therapy.
    Indian J Nephrol 2016 Nov-Dec;26(6):461-463
    Department of Microbiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh, India.
    Aminoglycoside nephrotoxicity may manifest as nonoliguric renal failure or tubular dysfunction, such as Fanconi-like syndrome, Bartter-like syndrome (BS), or distal renal tubular acidosis. We report a case who developed severe renal tubular dysfunction on the the 7(th) day of gentamicin therapy, resulting in metabolic alkalosis, refractory hypokalemia, hypocalcemia, hypomagnesemia, and polyuria. The patient was diagnosed as a case of transient BS associated with gentamicin exposure. Read More

    Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case-control study.
    Pharmacogenet Genomics 2017 Mar;27(3):83-88
    Departments of aPhysiology bGastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen cDepartment of Gastroenterology, Bernhoven Hospital, Uden dDepartment of Gastroenterology, Canisius-Wilhelmina-Hospital, Nijmegen, the Netherlands.
    Objective: Proton pump inhibitors (PPIs) are effective drugs for the treatment of gastric acid-related disorders. Serious adverse events are rare for PPIs, but recent data suggest that PPIs cause hypomagnesemia. The aim of this study was to estimate the frequency of PPI-induced hypomagnesemia and to define the risk factors for its development. Read More

    Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.
    J Cell Physiol 2016 Dec 7. Epub 2016 Dec 7.
    From the Laboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu, Japan.
    Anti-epidermal growth factor receptor (EGFR) drugs such as erlotinib and gefitinib cause a side effect of hypomagnesemia, but chemotherapy to treat this has not yet been developed. The transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of Mg(2+) in the renal tubule. We reported previously that the expression of TRPM6 is up-regulated by epidermal growth factor (EGF) in renal tubular epithelial NRK-52E and HEK293 cells. Read More

    Necitumumab for the treatment of squamous cell non-small cell lung cancer.
    J Oncol Pharm Pract 2016 Dec 2. Epub 2016 Dec 2.
    Department of Pharmacy, Levine Cancer Institute, 1021 Morehead Medical Drive, Charlotte, NC 28204, USA
    Non-small cell lung cancer is the most common form of lung cancer, accounting for about 85% of all cases and is further subdivided into adenocarcinoma, squamous cell, and large cell carcinoma. Necitumumab (Portrazza™, Eli Lilly and Company) is an anti-epidermal growth factor receptor monoclonal antibody approved for the first-line treatment of squamous cell non-small cell lung cancer in combination with cisplatin and gemcitabine. The safety and efficacy of necitumumab has been evaluated in two-phase III clinical trials, one demonstrating a lack of efficacy in non-squamous non-small cell lung cancer and another demonstrating improvement in overall survival and progression-free survival in squamous cell non-small cell lung cancer. Read More

    Inherited and acquired disorders of magnesium homeostasis.
    Curr Opin Pediatr 2016 Nov 30. Epub 2016 Nov 30.
    Division of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
    Purpose Of Review: Magnesium (Mg) imbalances are frequently overlooked. Hypermagnesemia usually occurs in preeclamptic women after Mg therapy or in end-stage renal disease patients, whereas hypomagnesemia is more common with a prevalence of up to 15% in the general population. Increasing evidence points toward a role for mild-to-moderate chronic hypomagnesemia in the pathogenesis of hypertension, type 2 diabetes mellitus, and metabolic syndrome. Read More

    Calcium pyrophosphate deposition disease and associated medical co-morbidities: A national cross-sectional study of us veterans.
    Arthritis Care Res (Hoboken) 2016 Nov 29. Epub 2016 Nov 29.
    Division of Rheumatology, Department of Medicine, University of Wisconsin, Madison and the William S Middleton VA Medical Center, Madison, WI, 53705.
    Objective: Calcium pyrophosphate crystal deposition disease (CPDD) is a common cause of acute and chronic arthritis, yet there are few large epidemiologic studies of CPDD. We sought to characterize CPDD in the national Veterans Affairs (VA) population.

    Methods: Patients with International Classification of Diseases, ninth revision (ICD-9) codes for CPDD seen at any VA medical center from 2010 through 2014 were matched by age and gender with control patients without CPDD, using data from the Department of Veterans Affairs Corporate Data Warehouse. Read More

    Frequency and Associated Factors of Amphotericin B Nephrotoxicity in Hospitalized Patients in Hematology-Oncology Wards in the Southwest of Iran.
    Nephrourol Mon 2016 Sep 3;8(5):e39581. Epub 2016 Jul 3.
    Nephrology-Urology Research Center, Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran.
    Background: Nephrotoxicity is the most clinically significant adverse reaction of amphotericin B. Different aspects of amphotericin B (AmB) nephrotoxicity have not been studied well in our population.

    Objectives: The purpose of this study was to assess the frequency, time onset, and possible associated factors of AmB nephrotoxicity in hospitalized patients in hematology-oncology wards in the southwest of Iran. Read More

    Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile.
    Medicine (Baltimore) 2016 Nov;95(47):e5166
    aDepartment of Pediatrics bDepartment of Clinical Pathology, Zagazig University, Egypt.
    Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency, having 25% to 39% prevalence. This deficit could be associated with the development of late diabetic complications, especially macroangiopathy.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assess its relation to glycemic control and lipid profile. Read More

    Reckless administration of QT interval-prolonging agents in elderly patients with drug-induced torsade de pointes.
    Z Gerontol Geriatr 2016 Nov 22. Epub 2016 Nov 22.
    Department of Internal Medicine and Geriatrics D, Sheba Medical Center, 5265601, Tel-Hashomer, Israel.
    A systematic review was conducted for all published case reports on drug-induced torsade de pointes (TdP) in elderly (≥80 years) patients to study if the administration of the offending agent was reckless. Overall, 61 reports on drug-induced TdP in patients aged 80-97 years were included in the analysis. Non-modifiable risk factors for drug-induced TdP (e. Read More

    Serum Magnesium and Mortality in Maintenance Hemodialysis Patients.
    Blood Purif 2016 Nov 23;43(1-3):31-36. Epub 2016 Nov 23.
    Department of Blood Purification, Chao-Yang Hospital, Capital Medical University, Beijing, China.
    Background And Aim: The study aimed to investigate the potential contributing effect of serum magnesium on mortality in maintenance hemodialysis (MHD) patients.

    Methods: The patients receiving regular MHD in March 2013 were involved. Baseline data including clinical data, anthropometrics and biochemical measurement were collected. Read More

    New SLC12A3 disease causative mutation of Gitelman's syndrome.
    World J Nephrol 2016 Nov;5(6):551-555
    Teresa Grillone, Francesco Bombardiere, Marco Flavio Michele Vismara, Fernanda Fabiani, Nicola Perrotti, Rodolfo Iuliano, Emma Colao, Medical Genetics Unit of "Mater Domini" University Hospital, University of Catanzaro, 88100 Catanzaro, Italy.
    Gitelman's syndrome (GS) is a salt-losing tubulopathy with an autosomal recessive inheritance caused by mutations of SLC12A3, which encodes for the thiazide-sensitive NaCl cotransporter. In this study we report a new mutation of SLC12A3 found in two brothers affected by GS. Hypokalemia, hypocalciuria and hyper-reninemia were present in both patients while hypomagnesemia was detected only in one. Read More

    Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats.
    Pflugers Arch 2016 Nov 19;468(11-12):1809-1821. Epub 2016 Nov 19.
    Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand.
    Hypomagnesemia is the most concerned side effect of proton pump inhibitors (PPIs) in chronic users. However, the mechanism of PPIs-induced systemic Mg(2+) deficit is currently unclear. The present study aimed to elucidate the direct effect of short-term and long-term PPIs administrations on whole body Mg(2+) homeostasis and duodenal Mg(2+) absorption in rats. Read More

    Phase II study of panitumumab and paclitaxel as first-line treatment in recurrent or metastatic head and neck cancer. TTCC-2009-03/VECTITAX study.
    Oral Oncol 2016 Nov 8;62:54-59. Epub 2016 Oct 8.
    Medical Oncology Service, Hospital Universitario Salamanca-IBSAL, Salamanca, Spain. Electronic address:
    Objective: To evaluate the activity and safety profile of panitumumab in combination with paclitaxel in patients with recurrent or metastatic SCCHN.

    Materials And Methods: The VECTITAX phase II, open-label, multicenter study included patients with confirmed metastatic and/or recurrent SCCHN deemed to be untreatable by surgery or radiotherapy and ECOG PS=0-1. All patients received paclitaxel (80mg/m(2)/week) and panitumumab (6mg/kg/2weeks) until disease progression or unacceptable toxicity. Read More

    Utility of optical coherence tomography in a case of bilateral congenital macular coloboma.
    Indian J Ophthalmol 2016 Sep;64(9):683-685
    Department of Nursing, Catholic University of Murcia, Murcia, Spain.
    Macular coloboma is a congenital defect of the retina and choroid in the macular region. It may appear due to an intrauterine inflammation or a developmental abnormality. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a result of malformation of the renal tubule. Read More

    Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.
    Magnes Res 2016 Apr;29(4):146-153
    Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067 Durango, Dgo. Mexico.
    A growing body of evidence shows the effect of magnesium on serum glucose, HDL-cholesterol, and triglycerides levels, as well as on blood pressure, which strongly suggests that magnesium might play an important role in metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type 2 diabetes. We performed a systematic review of clinical evidence derived from randomized, double-blind, controlled clinical trials, regarding the efficacy of magnesium supplementation on the components of MetS. Using the electronic databases of Medline, Embase, and the Cochrane Controlled Trials Register up to May 2016, we looked for randomized controlled trials focused on the effects of oral magnesium supplementation on insulin sensitivity, glucose, triglyceride and HDL-cholesterol levels, as well as its effects on high blood pressure, irrespective of the magnesium salt used, and with a duration of at least four weeks. Read More

    Incidence of hypophosphatemia in advanced cancer patients: a recent report from a single institution.
    Int J Clin Oncol 2016 Nov 10. Epub 2016 Nov 10.
    Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita, Japan.
    Background: Recent approval of molecular-targeted agents has contributed to improving the therapeutic outcomes of advanced cancer patients. However, they result in unusual adverse events that rarely occur with cytotoxic agents, such as hypertension, hypomagnesemia, and an acne-like rash. Although hypophosphatemia can be induced by various agents, some kinds of molecular-targeted agents are known to induce it. Read More

    Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity.
    Pulm Med 2016 12;2016:1643717. Epub 2016 Oct 12.
    Department of Biochemistry, Pramukhswami Medical College, Karamsad, Gujarat, India.
    Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Read More

    Serum phosphate and magnesium in children recovering from severe acute undernutrition in Ethiopia: an observational study.
    BMC Pediatr 2016 Nov 5;16(1):178. Epub 2016 Nov 5.
    Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, DK-1958, Denmark.
    Background: Children with severe acute malnutrition (SAM) have increased requirements for phosphorus and magnesium during recovery. If requirements are not met, the children may develop refeeding hypophosphatemia and hypomagnesemia. However, little is known about the effect of current therapeutic diets (F-75 and F-100) on serum phosphate (S-phosphate) and magnesium (S-magnesium) in children with SAM. Read More

    Hypomagnesemia in the ICU - Does Correction Matter?
    J Assoc Physicians India 2016 Nov;64(11):15-19
    Professor and Head of the Dept. of General Medicine, Bangalore Baptist Hospital, Bangalore, Karnataka.
    Background: Magnesium is a cation that is constantly being rediscovered. A number of studies have linked low magnesium levels to poor outcome of critically ill patients. Despite this hypomagnesemia continues to be under-recognized and uncorrected. Read More

    Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer.
    Ann Oncol 2016 Nov;27(11):2124-2130
    Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.
    Background: MUC16 is a tumor-specific antigen overexpressed in ovarian (OC) and pancreatic (PC) cancers. The antibody-drug conjugate (ADC), DMUC5754A, contains the humanized anti-MUC16 monoclonal antibody conjugated to the microtubule-disrupting agent, monomethyl auristatin E (MMAE).

    Patients And Methods: This phase I study evaluated safety, pharmacokinetics (PK), and pharmacodynamics of DMUC5754A given every 3 weeks (Q3W, 0. Read More

    Effects of Intraoperative Magnesium Sulfate Administration on Postoperative Tramadol Requirement in Liver Transplantation: A Prospective, Double-Blind Study.
    Transplant Proc 2016 Oct;48(8):2742-2746
    Department of Transplantation, Atasehir Memorial Hospital, Istanbul, Turkey.
    Background: Magnesium is an N-methyl-d-aspartate receptor blocker and is known to have analgesic effect. Hypomagnesemia can often be seen in liver transplantation and may be associated with higher morbidity and mortality. The objective of this study was to investigate the effects of intraoperative magnesium sulfate administration on postoperative tramadol requirement in liver transplant patients. Read More

    Cryptic exon activation in SLC12A3 in Gitelman syndrome.
    J Hum Genet 2017 Feb 27;62(2):335-337. Epub 2016 Oct 27.
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
    Gitelman syndrome (GS) is an autosomal recessive renal tubulopathy characterized by hypokalemic metabolic alkalosis with hypocalciuria and hypomagnesemia. GS clinical symptoms range from mild weakness to muscular cramps, paralysis or even sudden death as a result of cardiac arrhythmia. GS is caused by loss-of-function mutations in the solute carrier family 12 member 3 (SLC12A3) gene, but molecular mechanisms underlying such a wide range of symptoms are poorly understood. Read More

    A novel homozygous mutation in the solute carrier family 12 member 3 gene in a Chinese family with Gitelman syndrome.
    Braz J Med Biol Res 2016 Oct 24;49(11):e5261. Epub 2016 Oct 24.
    Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Loss of function of mutated solute carrier family 12 member 3 (SLC12A3) gene is the most frequent etiology for Gitelman syndrome (GS), which is mainly manifested by hypokalemia, hypomagnesemia and hypocalciuria. We report the genetic characteristics of one suspicious Chinese GS pedigree by gene sequencing. Complete sequencing analysis of the SLC12A3 gene revealed that both the proband and his elder sister had a novel homozygous SLC12A3 mutation: c. Read More

    Association of Serum Magnesium on Mortality in Patients Admitted to the Intensive Cardiac Care Unit.
    Am J Med 2017 Feb 14;130(2):229.e5-229.e13. Epub 2016 Sep 14.
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn. Electronic address:
    Background: Although electrolyte disturbances may affect cardiac action potential, little is known about the association between serum magnesium and corrected QT (QTc) interval as well as clinical outcomes.

    Methods: A consecutive 8498 patients admitted to the Mayo Clinic Hospital-Rochester cardiac care unit (CCU) from January 1, 2004 through December 31, 2013 with 2 or more documented serum magnesium levels, were studied to test the hypothesis that serum magnesium levels are associated with in-hospital mortality, sudden cardiac death, and QTc interval.

    Results: Patients were 67 ± 15 years; 62. Read More

    Modification of Total Magnesium level in pregnant Saudi Women developing gestational diabetes mellitus.
    Diabetes Metab Syndr 2016 Oct - Dec;10(4):183-185. Epub 2016 Jun 8.
    Maternity and Alhasa, Saudi Arabia.
    Background: The aim of our study is to measure total Magnesium in pregnant women screened for GDM and to compare total magnesium between whom were diagnosed having GDM and those having normal pregnancy.

    Methods: Our study is a prospective study involved 99 pregnant women referred to Maternity and Child Hospital Al Ahsa (Kingdom of Saudi Arabia) for 100g Oral Glucose Tolerance test. All included pregnant women were in their 24-28 weeks of gestation with free past medical history and were free for any medicine. Read More

    Determinants of hypomagnesemia in patients with type 2 diabetes mellitus.
    Eur J Endocrinol 2017 Jan 5;176(1):11-19. Epub 2016 Oct 5.
    Departments of Physiology
    Background: Hypomagnesemia (plasma magnesium (Mg(2+)) concentration <0.7 mmol/L) has been described in patients with type 2 diabetes. Polypharmacy is inevitable when treating a complex disease such as type 2 diabetes and could explain disturbances in the plasma Mg(2+) concentration. Read More

    Genetic parameters of subclinical macromineral disorders and major clinical diseases in postparturient Holstein cows.
    J Dairy Sci 2016 Nov 7;99(11):8901-8914. Epub 2016 Sep 7.
    Department of Animal Production, Faculty of Veterinary Medicine, Box 393, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. Electronic address:
    The main objective of this study was to assess the genetic parameters of subclinical disorders associated with subclinical hypocalcemia, hypophosphatemia, subclinical hypomagnesemia, hypokalemia, and hyperphosphatemia, as well as major clinical diseases after calving in Holstein cows. The secondary objective was to estimate the associated genetic and phenotypic correlations among these subclinical and clinical conditions after calving in Holstein cows. The study was conducted in 9dairy herds located in Northern Greece. Read More

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