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    2647 results match your criteria Hypomagnesemia

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    Is hungry bone syndrome a cause of postoperative hypocalcemia after total thyroidectomy in thyrotoxicosis? A prospective study with bone mineral density correlation.
    Surgery 2017 Nov 14. Epub 2017 Nov 14.
    Department of Endocrine Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.
    Background: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. Read More

    A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure.
    Sci Rep 2017 Nov 15;7(1):15623. Epub 2017 Nov 15.
    Rutgers-Robert Wood Johnson Medical School, Deptartment of Pharmacology, Piscataway, 08854, USA.
    In humans, germline mutations in Trpm6 cause autosomal dominant hypomagnesemia with secondary hypocalcemia disorder. Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally results in early embryonic lethality and neural tube closure defects. To define the mechanisms by which TRPM6 influences neural tube closure, we functionally characterized the role of TRPM6 during early embryogenesis in Xenopus laevis. Read More

    Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.
    Kidney Int 2017 Nov 10. Epub 2017 Nov 10.
    Institute of Physiology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Electronic address:
    The tight junction proteins claudin-10 and -16 are crucial for the paracellular reabsorption of cations along the thick ascending limb of Henle's loop in the kidney. In patients, mutations in CLDN16 cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis, while mutations in CLDN10 impair kidney function. Mice lacking claudin-16 display magnesium and calcium wasting, whereas absence of claudin-10 results in hypermagnesemia and interstitial nephrocalcinosis. Read More

    Chronic use of proton pump inhibitors, adverse events and potential biological mechanisms: A translational analysis.
    Therapie 2017 Oct 14. Epub 2017 Oct 14.
    Regional pharmacovigilance centre of Marseille Provence Corse, department of clinical pharmacology and pharmacovigilance, Assistance publique-Hôpitaux de Marseille, 270, boulevard Sainte-Marguerite, 13009 Marseille, France; CNRS 7289, neurosciences institute Timone, Aix-Marseille university, 13009 Marseille, France. Electronic address:
    Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI are usually considered as safe, there is a growing concern for a range of adverse effects of chronic PPI therapy often in the absence of appropriate indications. We propose, after a summary of renal, cardiovascular and neurological complications (dementia, chronic kidney disease, myocardial infarction and stroke), an integrative overview of the potential biological mechanisms involved. Read More

    Prevention of Chemotherapy-Induced Nephrotoxicity in Children with Cancer.
    Int J Prev Med 2017 5;8:76. Epub 2017 Oct 5.
    Department of Pediatrics, Division of Nephrology, Rush University Medical Center, Chicago, Illinois, USA.
    Children with cancer treated with cytotoxic drugs are frequently at risk of developing renal dysfunction. The cytotoxic drugs that are widely used for cancer treatment in children are cisplatin (CPL), ifosfamide (IFO), carboplatin, and methotrexate (MTX). Mechanisms of anticancer drug-induced renal disorders are different and include acute kidney injury (AKI), tubulointerstitial disease, vascular damage, hemolytic uremic syndrome (HUS), and intrarenal obstruction. Read More

    Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication.
    World J Gastroenterol 2017 Oct;23(37):6907-6910
    Department of Gastroenterology, Zealand University Hospital, 4600 Køge, Denmark.
    Magnesium deficiency can cause a variety of symptoms, including potentially life-threatening complications such as seizures, cardiac arrhythmias and secondary electrolyte disturbances. Hypomagnesemia can be a serious adverse effect to proton pump inhibitor (PPI) therapy, which is worrying due to the widespread use of PPIs. Current evidence suggest that the mechanism of PPI induced hypomagnesemia is impaired intestinal magnesium absorption. Read More

    Secondary Hyperparathyroidism in Heart Failure.
    Am J Med Sci 2017 Oct 2;354(4):335-338. Epub 2017 Mar 2.
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:
    Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca(2+) and Mg(2+) wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca(2+) overloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Read More

    Unusual Complication of Multidrug Resistant Tuberculosis.
    Case Rep Nephrol 2017 18;2017:6835813. Epub 2017 Sep 18.
    Division of Medicine, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai 400 012, India.
    Introduction: Capreomycin is a second-line drug often used for multidrug-resistant tuberculosis which can result in nephrotoxic effects similar to other aminoglycosides. We describe a case of capreomycin induced Bartter-like syndrome with hypocalcemic tetany.

    Case Report: 23-year-old female patient presented with carpopedal spasms and tingling sensations in hands. Read More

    A Case of Renal Tubular Acidosis with Sjogren's Syndrome Showing Paradoxical Block of PTH Due to Severe Hypomagnesemia.
    Indian J Clin Biochem 2017 Oct 18;32(4):496-499. Epub 2016 Dec 18.
    Sundaram Medical Foundation, Dr. Rangarajan Memorial Hospital, 9C, IV Avenue, Shanthi Colony, Anna Nagar, Chennai, 600040 India.
    Distal renal tubular acidosis (RTA) manifests either as Complete/Classical form or Incomplete/Latent Form. Distal RTA causes normal anion gap metabolic acidosis and hypokalemia. Interstitial Nephritis is the most frequent renal manifestation of Sjogren's, which presents as Distal RTA in 25-40% of patients with Sjogren's syndrome. Read More

    Micronutrients Drift During Daily and Weekly Iron Supplementation in Non-anaemic and Anaemic Pregnancy.
    Indian J Clin Biochem 2017 Oct 17;32(4):473-479. Epub 2017 Jan 17.
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
    Aims: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum. Read More

    Incidence of hyperglycemia and diabetes and association with electrolyte abnormalities in pediatric solid organ transplant recipients.
    Nephrol Dial Transplant 2017 Sep;32(9):1579-1586
    Department of Pediatrics, Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, ON, Canada.
    Background: Posttransplant hyperglycemia is an important predictor of new-onset diabetes after transplantation, and both are associated with significant morbidity and mortality. Precise estimates of posttransplant hyperglycemia and diabetes in children are unknown. Low magnesium and potassium levels may also lead to diabetes after transplantation, with limited evidence in children. Read More

    Comparison between serum magnesium levels of asphyxiated neonates and normal cases.
    Med J Islam Repub Iran 2017 9;31:19. Epub 2017 Mar 9.
    Ali-Asghar Children's Hospital, Iran University of Medical Science, Tehran, Iran.
    Background: Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magnesium in neonates with and without asphyxia. Read More

    A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8147
    aDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University bDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
    Rationale: Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

    Patient Concerns: A 62-year-old woman with short-bowel syndrome related with multiple resections of small intestines due to Crohn disease received regular intravenous administration of saccharated ferric oxide. Read More

    Durable complete remission following anti-EGFR antibodies in recurrent metastatic colorectal cancer.
    J Oncol Pharm Pract 2017 Jan 1:1078155217730130. Epub 2017 Jan 1.
    4 Department of Pharmacy, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
    In this case report, we describe a patient who remains in complete remission two years after the discontinuation of anti-EGFR monotherapy as a third-line treatment, accompanied by persistent severe hypomagnesemia. A 45-year-old Caucasian woman with mCRC started chemotherapy with weekly cetuximab. After ten months of treatment, the therapy was stopped because the patient had persistent grade III hypomagnesemia despite amiloride, oral, and intravenous magnesium. Read More

    Effect of Magnesium Supplement on Pregnancy Outcomes: A Randomized Control Trial.
    Adv Biomed Res 2017 31;6:109. Epub 2017 Aug 31.
    Department of Obstetrics and Gynecology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Magnesium (Mg) is an essential mineral required to regulate body temperature, nucleic acid, and protein synthesis with an important role in maintaining nerve and muscle cell electrical potentials. It may reduce fetal growth restriction and preeclampsia as well as increase birth weight. This study aimed to assess the effects of consuming Mg supplementation during pregnancy on pregnancy outcomes. Read More


    Hypertension and cardiac arrhythmias: a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).
    Europace 2017 Jun;19(6):891-911
    University of Wisconsin, Clinical Science Center, Madison, USA.
    Hypertension is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease, stroke, peripheral artery disease and chronic renal insufficiency. Hypertensive heart disease can manifest as many cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in hypertensive patients, especially in those with left ventricular hypertrophy (LVH) or HF. Read More

    [Expert consensus for the diagnosis and treatment of patients with Gitelman syndrome].
    • Authors:
    Zhonghua Nei Ke Za Zhi 2017 Sep;56(9):712-716
    Gitelman syndrome (GS) is an autosomal recessive, salt-losing tubulopathy caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is characterized by hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. GS is one of the most common inherited renal tubulopathy with a prevalence estimated at about one to ten per 40 000 people. Read More

    Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial.
    Ann Transplant 2017 Aug 29;22:524-531. Epub 2017 Aug 29.
    Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
    BACKGROUND Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and in transplant recipients. We aimed to assess whether magnesium improves insulin secretion and glycemic control after transplantation in prevalent hypomagnesemic kidney transplant recipients. Read More

    Inherited, not acquired, Gitelman syndrome in a patient with Sjögren's syndrome: importance of genetic testing to distinguish the two forms.
    CEN Case Rep 2017 Nov 17;6(2):180-184. Epub 2017 Aug 17.
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Gitelman syndrome (GS) is an autosomal recessive, salt-losing renal tubulopathy caused by mutations in the SLC12A3 gene; however, it can also be acquired in patients with autoimmune disease, especially in those with Sjögren's syndrome. Differentiating between the inherited and acquired forms of GS is clinically difficult. We report a case of inherited, not acquired, GS in a patient with Sjögren's syndrome. Read More

    Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.
    Cell Commun Signal 2017 Aug 15;15(1):30. Epub 2017 Aug 15.
    Center for Biomedical Research, The Queen's Medical Center, John A. Burns School of Medicine, University of Hawaii, 1301 Punchbowl St., Honolulu, HI, 96813, USA.
    Background: Magnesium (Mg(2+)) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg(2+) homeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. Read More

    Proton Pump Inhibitors: More Indigestion than Relief?
    Indian J Nephrol 2017 Jul-Aug;27(4):249-257
    Department of Medicine, Division of Nephrology, The Ottawa Hospital, Ottawa, Canada.
    Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also been recently reported. Read More

    Gitelman syndrome: an analysis of the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities.
    Int Urol Nephrol 2017 Jul 25. Epub 2017 Jul 25.
    Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece.
    Gitelman syndrome is the most common inherited tubular disease resulting from mutations of the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter in the early distal convoluted tubules. The review presents the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities observed in patients with Gitelman syndrome. The syndrome is usually characterized by hypokalemic metabolic alkalosis in combination with hypomagnesemia and hypocalciuria. Read More

    The effects of zoledronic acid on ECG: a prospective study on patients with bone metastatic cancer.
    Clin Cases Miner Bone Metab 2017 Jan-Apr;14(1):35-39. Epub 2017 May 30.
    Bulent Ecevit University, Zonguldak, Turkey.
    Introduction: There are controversial results in the risk of atrial fibrillation as well as arrhythmogenic potential of bis-phosphonates.

    Method: 37 patients and 40 healthy controls were evaluated prospectively with regard to the cardiac side effects related to the use of zoledronic acid (ZA) and its effects on electrocardiography (ECG) parameters.

    Result: As the basal ECG results of the patients diagnosed with cancer compared with the control group, it was determined that QT maximum was significantly lower, QT minimum was significantly higher. Read More

    Peptide Receptor Radionuclide Therapy-Induced Gitelman-like Syndrome.
    Am J Kidney Dis 2017 Nov 21;70(5):725-728. Epub 2017 Jul 21.
    Emergency Department, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
    Peptide receptor radionuclide therapy (PRRT) is a molecular-targeted therapy in which a somatostatin analogue (a small peptide) is coupled with a radioligand so that the radiation dose is selectively administered to somatostatin receptor-expressing metastasized neuroendocrine tumors, particularly gastroenteropancreatic. Reported toxicities include myelotoxicity and nephrotoxicity, the latter manifesting as decreased kidney function, often developing months to years after treatment completion. We present a case of PRRT-induced kidney toxicity manifesting as a severe Gitelman-like tubulopathy with preserved kidney function. Read More

    Biological agents in gastrointestinal cancers: adverse effects and their management.
    J Gastrointest Oncol 2017 Jun;8(3):485-498
    Division of Hematology/Oncology, Springfield Clinic Cancer Center, Springfield, Illinois, USA.
    Biological therapy comprises agents that by virtue of their unique mechanisms of action, are able to specifically incite a response against or target malignant cells. They differ from conventional chemotherapy with regard to mechanisms of action, indications and side effect profile. Biologic agents have revolutionized therapy for a number of malignancies. Read More

    Electrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management.
    Cancer Chemother Pharmacol 2017 Nov 20;80(5):895-907. Epub 2017 Jul 20.
    Walter Reed National Military Medical Center, 8901 Wisconsin Ave, Bethesda, MD, 20889, USA.
    Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia, hypocalcemia and hyponatremia. The corpus of literature on these dyselectrolytemias is large; the objective of this review is to synthesize the literature and summarize the mechanisms responsible for these particular electrolyte disturbances in the context of platinum-based treatment as well as to present the clinical manifestations and current management strategies for oncologists and primary care physicians, since the latter are increasingly called on to provide care for cancer patients with medical comorbidities. Correct diagnosis and effective treatment are essential to improved patient outcomes. Read More

    TETANY WITH HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPOCALCEMIA AS INITIAL PRESENTATION OF CELIAC DISEASE.
    Gastroenterol Nurs 2017 Jul 19. Epub 2017 Jul 19.
    Emrah Posul, MD, Department of Gastroenterology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Guray Can, MD, Department of Gastroenterology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Vildan Tekelioglu, MD, Department of Internal Medicine, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Bulent Yilmaz, MD, Department of Gastroenterology, Bolu Izzet Baysal State Hospital, Bolu, Turkey. Ugur Korkmaz, MD, is Associate Professor, Department of Gastroenterology, Bolu Izzet Baysal State Hospital, Bolu, Turkey. Gulzade Ozyalvacli, MD, is Assistant Professor, Department of Pathology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Asuman Kilitci, MD, Department of Pathology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Mevlut Kurt, MD, is Associate Professor, Department of Gastroenterology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

    Hypomagnesemia and cause-specific mortality in hemodialysis patients: 5-year follow-up analysis.
    Int J Artif Organs 2017 Oct 1;40(10):542-549. Epub 2017 Jul 1.
    University Clinic of Nephrology, Saints Cyril and Methodius University, Skopje - Republic of Macedonia.
    Introduction: The aim of this prospective study was to evaluate the association between serum magnesium (Mg) and mortality, in particular the cause-specific mortality of Mg and other risk factors in hemodialysis (HD) patients.

    Methods: We studied a cohort of 185 HD patients receiving thrice-weekly HD treatment, on a dialysate Mg concentration of 0.5 mmol/L. Read More

    Effectiveness and Safety of Magnesium Replacement in Critically Ill Patients Admitted to the Medical Intensive Care Unit in an Academic Medical Center: A Retrospective, Cohort Study.
    J Intensive Care Med 2017 Jan 1:885066617720631. Epub 2017 Jan 1.
    3 Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Chicago, IL, USA.
    Background: "Rules of thumb" for the replacement of electrolytes, including magnesium, in critical care settings are used, despite minimal empirical validation of their ability to achieve a target serum concentration. This study's purpose was to evaluate the effectiveness and safety surrounding magnesium replacement in medically, critically ill patients with mild-to-moderate hypomagnesemia.

    Methods: This was a single-center, retrospective, observational evaluation of episodes of intravenous magnesium replacement ordered for patients with mild-to-moderate hypomagnesemia (1. Read More

    Is endothelin gene polymorphism associated with postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting?
    Ann Card Anaesth 2017 Jul-Sep;20(3):341-347
    Department of Biostatistics, All Institute of Medical Sciences, New Delhi, India.
    Background: The mechanism of development of atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG) has not been clearly defined, and the involvement of multiple factors such as advanced age, withdrawal of β-blockers, inadequate atrial protection, and electrolyte imbalance, particularly hypomagnesemia has been documented by several authors. Despite all the available pharmacologic prophylaxis, incidence of AF still remains high in this group of patients. This unexplained cause could be genetic inheritance of endothelin-1 (ET-1) gene which is thought to have a pro-arrhythmogenic effect. Read More

    [Magnesium in daily practice].
    Rev Med Suisse 2016 Oct;12(535):1761-1765
    Service de médecine interne générale, Département de médecine interne, réhabilitation et gériatrie, HUG, 1211 Genève 14.
    The magnesium is the 4th cation in the human body behind sodium, potassium and calcium. It is often referred to as the forgotten cation of modern medicine because of a lack of knowledge about its physiology and its potential medical use. Recent medical literature has shown renewed interest for the magnesium with publications about its role in diversified fields from prevention of muscular cramps, cardiovascular risk factors prevention trough to neuroprotection in stroke. Read More

    Phase II Trial of Sorafenib in Combination with Capecitabine in Patients with Hepatocellular Carcinoma: INST 08-20.
    Oncologist 2017 Oct 7;22(10):1158-e116. Epub 2017 Jul 7.
    Department of Hematology/oncology, University of New Mexico, Albuquerque, New Mexico, USA.
    Lessons Learned: There continues to be a lack of systemic options for advanced hepatocellular carcinoma (HCC); sorafenib and, very recently, regorafenib are the only approved options. There exists a potential to combine sorafenib with chemotherapeutic agents shown to be active in HCC, such as capecitabine, safely.Good tumor response was observed, with objective improvement in a few patients seldom seen by single agent sorafenib; however, because of the limited number of patients, meaningful conclusions on survival cannot be drawn. Read More

    Ionized magnesium in plasma and erythrocytes for the assessment of low magnesium status in alcohol dependent patients.
    Drug Alcohol Depend 2017 Sep 24;178:271-276. Epub 2017 Jun 24.
    Department of Psychiatry, Medical University of Warsaw, Poland.
    Background: Studies on the homeostasis of magnesium in alcohol-dependent patients have often been characterized by low hypomagnesemia detection rates. This may be due to the fact that the content of magnesium in blood serum constitutes only 1% of the average magnesium level within the human body. However, the concentration of ionized magnesium is more physiologically important and makes up 67% of the total magnesium within a human organism. Read More

    Long-lasting response to oral therapy in a young male with monogenic diabetes as part of HNF1B-related disease.
    Endocrinol Diabetes Metab Case Rep 2017 23;2017. Epub 2017 Jun 23.
    Endocrinologists in Complejo Hospitalario Universitario de Albacete, Castilla La ManchaSpain.
    Mutations in hepatocyte nuclear factor 1β gene (HNF1B) are responsible for a multisystemic syndrome where monogenic diabetes (classically known as MODY 5) and renal anomalies, mostly cysts, are the most characteristic findings. Urogenital malformations, altered liver function tests, hypomagnesemia or hyperuricemia and gout are also part of the syndrome. Diabetes in these patients usually requires early insulinization. Read More

    Magnesium Counteracts Vascular Calcification: Passive Interference or Active Modulation?
    Arterioscler Thromb Vasc Biol 2017 Aug 29;37(8):1431-1445. Epub 2017 Jun 29.
    From the Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands (A.D.t.B., J.H.F.d.B.); Cardiovascular Division, BHF Centre of Research Excellence, James Black Centre, King's College, London, United Kingdom (C.M.S.); and Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom (J.H.F.d.B.).
    Over the last decade, an increasing number of studies report a close relationship between serum magnesium concentration and cardiovascular disease risk in the general population. In end-stage renal disease, an association was found between serum magnesium and survival. Hypomagnesemia was identified as a strong predictor for cardiovascular disease in these patients. Read More

    Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia.
    Case Rep Cardiol 2017 5;2017:6250312. Epub 2017 Jun 5.
    Heart & Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.
    Magnesium is the second most common intracellular cation and serves as an important metabolic cofactor to over 300 enzymatic reactions throughout the human body. Among its various roles, magnesium modulates calcium entry and release from sarcoplasmic reticulum and regulates ATP pumps in myocytes and neurons, thereby regulating cardiac and neuronal excitability. Therefore, deficiency of this essential mineral may result in serious cardiovascular and neurologic derangements. Read More

    A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis.
    N Engl J Med 2017 06;376(24):2329-2340
    From Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit (T.L., N.T.T., T.P.T., N.T.H., H.B.L., H.T.N., H.F.L.W., J.N.D., J.F., G.T., M.W.), and the Hospital for Tropical Diseases (N.T.K.C., N.L.N.T., N.V.V.C.), Ho Chi Minh City, the National Hospital for Tropical Diseases (N.V.K., N.T.L.) and Bach Mai Hospital (P.T.T.T., D.D.C.), Hanoi, Viet Tiep Hospital, Hai Phong (P.T.H.P., V.H.V.), and Vietnam-Sweden Uong Bi Hospital, Quang Ninh (D.T.H.H., V.V.T.) - all in Vietnam; the Centre for Tropical Medicine and Global Health (T.L., J.N.D., G.T., M.W.), and the Worldwide Antimalarial Resistance Network (L.M.), University of Oxford, Oxford, United Kingdom; the Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands (H.F.L.W.); and the Hawaii Center for AIDS, University of Hawaii at Manoa, Honolulu (T.L., C.S.).
    Background: Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-related death in South and Southeast Asia. Guidelines recommend initial treatment with amphotericin B deoxycholate, but this drug has substantial side effects, a high cost, and limited availability. Itraconazole is available in oral form, is associated with fewer unacceptable side effects than amphotericin, and is widely used in place of amphotericin; however, clinical trials comparing these two treatments are lacking. Read More

    Clinical aspects of magnesium physiology in patients on dialysis.
    Semin Dial 2017 Sep 13;30(5):438-445. Epub 2017 Jun 13.
    Division of Nephrology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
    Magnesium balance is infrequently discussed in the dialysis population, and the clinical consequences of derangements in magnesium homeostasis are incompletely understood. There is an association between hypomagnesemia and adverse outcomes including increases in cardiovascular disease and mortality, while elevated magnesium levels have also been linked with complications such as osteomalacia. In this review, we discuss the features of magnesium physiology relevant to dialysis patients and provide an updated summary of the literature linking magnesium derangements with bone disease, cardiovascular disease, sudden cardiac death, and mortality. Read More

    Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis.
    Front Physiol 2017 24;8:326. Epub 2017 May 24.
    Laboratory Orofacial Pathologies, Imaging and Biotherapies, Dental School, Paris Descartes University, Sorbonne Paris CitéParis, France.
    Claudins are a family of proteins that forms paracellular barriers and pores determining tight junctions (TJ) permeability. Claudin-16 and -19 are pore forming TJ proteins allowing calcium and magnesium reabsorption in the thick ascending limb of Henle's loop (TAL). Loss-of-function mutations in the encoding genes, initially identified to cause Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC), were recently shown to be also involved in Amelogenesis Imperfecta (AI). Read More

    Multicenter Phase II Study of Panitumumab in Platinum Pretreated, Advanced Head and Neck Squamous Cell Cancer.
    Oncologist 2017 Jul 7;22(7):782-e70. Epub 2017 Jun 7.
    Oncology Institute of Southern Switzerland, San Giovanni Hospital, Bellinzona, Switzerland.
    Lessons Learned: Panitumumab shows activity in terms of disease control rate and preventing disease progression but not for tumor shrinkage in head and neck squamous cell cancer for second-line treatment. Epidermal growth factor receptor (EGFR) copy number gain, a property of tumor cells that theoretically could identify patients more likely to experience disease response, was common among patients having disease control.Our trial, given the lower toxicity with an every-2-week schedule, provides guidance for future trials, for example, in combinations of immune therapies and anti-EGFR-antibodies. Read More

    Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.
    Kidney Int 2017 Nov 31;92(5):1145-1156. Epub 2017 May 31.
    Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, Netherlands. Electronic address:
    Hepatocyte nuclear factor 1 homeobox B (HNF1β) is an essential transcription factor for the development and functioning of the kidney. Mutations in HNF1β cause autosomal dominant tubulointerstitial kidney disease characterized by renal cysts and maturity-onset diabetes of the young (MODY). Moreover, these patients suffer from a severe electrolyte phenotype consisting of hypomagnesemia and hypokalemia. Read More

    Pharmacoepidemiology of tacrolimus in pediatric liver transplantation.
    Pediatr Transplant 2017 Aug 2;21(5). Epub 2017 Jun 2.
    Liver Transplantation, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina.
    AEs during immunosuppressive treatment with tacrolimus are very common. We retrospectively evaluated FK safety and efficacy in a large pediatric liver transplant cohort in Latin America. During 2-year follow-up, we analyzed data from patients who underwent liver transplantation over the period 2010-2012 and recorded FK exposure, AEs, and AR episodes. Read More

    Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman.
    Br J Clin Pharmacol 2017 Sep 31;83(9):2120-2122. Epub 2017 May 31.
    Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.
    In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c. Read More

    Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria.
    Indian J Endocrinol Metab 2017 May-Jun;21(3):439-442
    Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
    Background: Magnesium (Mg) is the 4(th) most common mineral and the 2(nd) most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states.

    Aim: The aim of this study was to study the patterns and correlates of serum Mg in cohorts of type 2 diabetic patients in Nigeria. Read More

    Hypomagnesemia predicts postoperative biochemical hypocalcemia after thyroidectomy.
    BMC Surg 2017 May 25;17(1):62. Epub 2017 May 25.
    Department of Thyroid & Parathyroid surgery, West China Hospital, Sichuan University, Guoxue Alley 37#, Chengdu, Sichuan, 610041, People's Republic of China.
    Background: To investigate the role of magnesium in biochemical and symptomatic hypocalcemia, a retrospective study was conducted.

    Methods: Less-than-total thyroidectomy patients were excluded from the final analysis. Identified the risk factors of biochemical and symptomatic hypocalcemia, and investigated the correlation by logistic regression and correlation test respectively. Read More

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