15,562 results match your criteria Hypokalemia

Severe Hypokalemia and Metabolic Alkalosis Caused by Licorice Discovered During the Treatment of Intraoperative Hypoxemia.

Cureus 2022 May 28;14(5):e25432. Epub 2022 May 28.

Department of Anesthesiology, Kameda Medical Center, Kamogawa, JPN.

One of the causes of preoperative hypokalemia is the prolonged use of herbal medicines, especially licorice. Licorice can induce pseudo-aldosteronism, hypertension, metabolic alkalosis, and hypokalemia. An 87-year-old woman with a history of knee osteoarthritis was scheduled to undergo a total knee arthroplasty (TKA) under spinal anesthesia. Read More

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A Novel Frame-Shift Mutation in Identified in a Chinese Family Characterized by Early-Onset Hypertension.

Front Cardiovasc Med 2022 14;9:896564. Epub 2022 Jun 14.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Liddle syndrome is a form of monogenic hypertension caused by mutations in the three homologous subunits of the epithelial sodium channels (ENaCs), α, β, and γ. It is characterized by early-onset refractory hypertension, hypokalemia, low renin activity, and hypoaldosteronism. In this study, we report a novel frame-shift mutation in responsible for Liddle syndrome in a Chinese family. Read More

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Treatment Prediction in the ICU Setting Using a Partitioned, Sequential Deep Time Series Analysis.

Stud Health Technol Inform 2022 Jun;295:360-361

Department of Software and Information Systems Engineering (SISE).

We developed a neural network architecture to evaluate the patient's state using temporal data, patient's demographics and comorbidities. We examined the model's ability to predict both a binary medication-treatment decision and its specific dose in three common scenarios: hypokalemia, hypoglycemia and hypotension. We partition the common 12-hours horizon window into three sub-windows, examining how patterns of treatment evolve following a key clinical event or state. Read More

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Hypokalemic Quadriparesis As Initial Presentation of Secondary Sjogren Syndrome With Associated Autoimmune Thyroiditis: A Case Report.

Cureus 2022 May 27;14(5):e25420. Epub 2022 May 27.

Internal Medicine, Holy Family Hospital, Rawalpindi, PAK.

Sjögren's syndrome is an autoimmune disorder typically presenting as dry mouth and eyes (sicca syndrome). However, the disease can involve any organ, complicating diagnosis. Renal involvement may manifest as distal renal tubular acidosis, leading to hypokalemia. Read More

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[Genotype-phenotype analysis and prognosis in children with primary distal renal tubular acidosis].

Zhonghua Er Ke Za Zhi 2022 Jul;60(7):700-705

Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

The purpose of this study was to investigate the relationship between genotypes and clinical phenotypes of primary distal renal tubular acidosis (dRTA) in children. Clinical information, genetic testing information and follow-up data (until March 2021) of children with dRTA from Children's Hospital of Chongqing Medical University (from January 2010 to December 2020) were analyzed retrospectively. According to different pathogenic genes, patients were divided into SLC4A1 gene and ATP6V0A4+ATP6V1B1 gene groups. Read More

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Phase I Trial of a Novel Anti-HER2 Antibody-Drug Conjugate, ARX788, for the Treatment of HER2-Positive Metastatic Breast Cancer.

Clin Cancer Res 2022 Jun 29:OF1-OF10. Epub 2022 Jun 29.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibody. Herein, we present the results of a phase I study of the safety, pharmacokinetics, and antitumor activity of ARX788 in patients with HER2-positive metastatic breast cancer (MBC).

Patients And Methods: Patients with HER2-positive MBC received ARX788 at doses of 0. Read More

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Exposure-safety relationship for acyclovir in the treatment of neonatal herpes simplex virus disease.

Early Hum Dev 2022 Jun 22;170:105616. Epub 2022 Jun 22.

Department of Pediatrics, Duke University School of Medicine, Durham, NC, United States of America. Electronic address:

Background: Neonatal herpes simplex virus (HSV) disease has been treated with high-dose (20 mg/kg/dose) acyclovir since 1991.

Aims: Determine the safety of acyclovir in infants with neonatal HSV treated with high-dose acyclovir; examine the association between acyclovir dose and exposure with adverse events (AEs).

Study Design: We obtained demographic information and acyclovir dosing via medical records. Read More

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Ambulatory fludrocortisone suppression test in the diagnosis of primary aldosteronism: safety, accuracy and cost-effectiveness.

Clin Endocrinol (Oxf) 2022 Jun 27. Epub 2022 Jun 27.

Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.

Objective: The aims of this study were to explore if the ambulatory FST was safe, accurate, and cost-effective.

Context: The diagnosis of primary aldosteronism (PA) remains time-consuming and complex. The fludrocortisone suppression test (FST) is used to confirm PA, but it is an in-patient test due to potentially serious complications such as hypokalemia. Read More

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Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge.

BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Internal Medicine, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.

Acute-onset quadriparesis is not only debilitating and a grave concern for the patient but also perturbs the clinician as it demands early diagnosis and prompt management to prevent catastrophic outcome due to respiratory failure. Guillain-Barré syndrome (GBS) and hypokalaemia are notorious causes of acute-onset lower motor neuron (LMN) quadriparesis and warrant a rapid evaluation to necessitate early management. However, coexistence of these two entities is extremely rare and may pose a diagnostic and therapeutic challenge and mandates exclusion of either condition to avoid a poor outcome. Read More

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Case Report: Fanconi-Bickel Syndrome in a Chinese Girl With Diabetes and Severe Hypokalemia.

Front Pediatr 2022 9;10:897636. Epub 2022 Jun 9.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive carbohydrate metabolism disorder. The main symptoms of FBS are hepatomegaly, nephropathy, postprandial hyperglycemia, fasting hypoglycemia, and growth retardation. Hypokalemia is a rare clinical feature in patients with FBS. Read More

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Childbirth with epidural analgesia in a pregnant woman with hypokalemic periodic paralysis.

Rev Esp Anestesiol Reanim (Engl Ed) 2022 Jun 23. Epub 2022 Jun 23.

Servicio de Urgencias, Hospital Obispo Polanco, Teruel, Spain.

Familial hypokalaemic periodic paralysis (FHPP) is an uncommon genetic disease characterized by muscle weakness associated with hypokalaemia. Episodes are precipitated by drugs, stress, metabolic diseases, hypothermia or infection. We report the case of a 38-year-old pregnant women with FHPP who underwent epidural analgesia for labour. Read More

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Fanconi syndrome in an elderly patient with membranous nephropathy during treatment with the immunosuppressant mizoribine.

CEN Case Rep 2022 Jun 24. Epub 2022 Jun 24.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

We report on an 80-year-old man diagnosed with Fanconi syndrome induced by mizoribine after 4 weeks of administration to treat membranous nephropathy. Mizoribine is an oral immunosuppressant that inhibits inosine monophosphate dehydrogenase and is widely used in Japan for the treatment of autoimmune diseases and nephrotic syndrome, as well as after renal transplantation. Acquired Fanconi syndrome is often caused by drugs (antibacterial, antiviral, anticancer, and anticonvulsant drugs) and is sometimes caused by autoimmune diseases, monoclonal light chain-associated diseases, or heavy metal poisoning. Read More

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Cisplatin-induced nephrotoxicity in childhood cancer: comparison between two countries.

Pediatr Nephrol 2022 Jun 24. Epub 2022 Jun 24.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Background: Various definitions used to describe cisplatin nephrotoxicity potentially lead to differences in determination of risk factors. This study evaluated incidence of kidney injury according to commonly used and alternative definitions in two cohorts of children who received cisplatin.

Methods: This retrospective cohort study included children from Vancouver, Canada (one center), and Mexico City, Mexico (two centers), treated with cisplatin for a variety of solid tumors. Read More

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Role of glucocorticoid receptor mutations in hypertension and adrenal gland hyperplasia.

Pflugers Arch 2022 Jun 22. Epub 2022 Jun 22.

National Center of Competence in Research, Kidney.CH, CH-1011, Lausanne, Switzerland.

Hypertension is one of the leading causes of premature death in humans and exhibits a complex aetiology including environmental and genetic factors. Mutations within the glucocorticoid receptor (GR) can cause glucocorticoid resistance, which is characterized by several clinical features like hypercortisolism, hypokalaemia, adrenal hyperplasia and hypertension. Altered glucocorticoid receptor signalling further affects sodium and potassium homeostasis as well as blood pressure regulation and cell proliferation and differentiation that influence organ development and function. Read More

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Higher parenteral electrolyte intakes in preterm infants during first week of life: Effects on electrolyte imbalances.

J Pediatr Gastroenterol Nutr 2022 Jun 20. Epub 2022 Jun 20.

Department of Clinical Sciences, Pediatrics, Umeå University, SE-901 85 Umeå, Sweden.

Objectives: This study aimed to investigate the effects of a higher intake of electrolytes from parenteral nutrition (PN) on plasma electrolyte concentrations in very low birth weight (VLBW, <1500 g) infants.

Methods: This was a single-centre cohort study including all VLBW infants born before (n=81) and after (n=53) the implementation of a concentrated PN regimen. Daily nutritional intakes and plasma concentrations of sodium, chloride, potassium, phosphate, and calcium were collected from clinical charts. Read More

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Liddle syndrome misdiagnosed as primary aldosteronism is caused by inaccurate aldosterone-rennin detection while a novel mutation is discovered.

Blood Press 2022 12;31(1):139-145

Department of Endocrinology, Shanghai Public Health Clinical Center, Shanghai, China.

Purpose: Through describing the confusing misdiagnosis process of Liddle syndrome, we try to reveal the importance of accurate aldosterone-renin detection and a genetic test for Liddle syndrome.

Methods: We found a family of hypertension and hypokalaemia with the proband of a 21-year-old female who had been misdiagnosed as primary aldosteronism (PA). She presented with high aldosterone and low renin levels. Read More

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December 2022

Genetic Heterogeneity in Bartter Syndrome: Clinical and Practical Importance.

Front Pediatr 2022 3;10:908655. Epub 2022 Jun 3.

Department of Medical Genetics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Bartter syndrome (BS) is a rare tubulopathy that causes polyuria, hypokalemia, hypochloremic metabolic alkalosis, and normotensive hyperreninemic hyperaldosteronism. It is characterized by locus, clinical, and allelic heterogeneity. Types 1-4 of BS are inherited according to an autosomal recessive pattern, while type 5, which is transient, is X linked. Read More

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Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology.

Intern Med J 2022 Jun 19. Epub 2022 Jun 19.

Neurological Intervention & Imaging Service of WA (NIISwa), Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia.

Background: Osmotic demyelination syndrome (ODS) is non inflammatory demyelination in response to an osmotic challenge. It can be pontine or extrapontine in presentation AIM: Retrospective review of cases involving ODS and define the spectrum of causes, risk factors, clinical and radiological presentations, and functional outcomes.

Results: The study utilized data from 15 patients with a mean age of 53. Read More

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Clinical Course of Patients with Bartter Syndrome.

Iran J Kidney Dis 2022 May;16(3):162-170

1Intrdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Brazil.

Introduction: Bartter syndrome (BS) is a salt losing tubulopathy due to impairment of the transport mechanisms at the thick ascending limb of the Henle's loop. The aim of this study was to report the clinical course of patients with BS.

Methods: Patients with BS were followed from 1996 to 2020 and enrolled to a systematic protocol to confirm primary BS by evaluating the metabolic derangements, nephrolithiasis and nephrocalcinosis. Read More

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Colistin-induced Bartter-like Syndrome: Ponder before Treatment!

Indian J Crit Care Med 2022 Feb;26(2):239-243

Department of Nephrology, Safdarjung Hospital and Vardhman Mahavir Medical College, New Delhi, India.

Bartter-like syndrome (BLS) is a constellation of biochemical abnormalities which include metabolic alkalosis, hypokalemia, hypocalcemia, hypomagnesemia with normal kidney function. BLS is a very rare syndrome and can be induced by certain diseases, antibiotics, diuretics, and antineoplastic drugs. Colistin is a polymicrobial bactericidal drug and currently re-emerged as the only salvation therapy against multidrug resistant bacilli especially in critically ill patients at intensive care units. Read More

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February 2022

Electrolyte Abnormalities Associated With the Use of Atezolizumab - A Systematic Review.

J Community Hosp Intern Med Perspect 2022 12;12(2):35-44. Epub 2022 Apr 12.

Department of Internal Medicine, McLaren Flint Michigan State University, Flint, MI, USA.

Background And Objectives: In recent years, immune-checkpoint inhibitors (ICIs) particularly atezolizumab is on the rise in treating advanced malignancies. With its increased clinical use, various electrolyte abnormalities have been reported in the literature. In this review, we have addressed the question of significant electrolyte abnormalities associated with atezolizumab. Read More

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Case Report: Primary Aldosteronism and Subclinical Cushing Syndrome in a 49-Year-Old Woman With Hypertension Plus Hypokalaemia.

Front Cardiovasc Med 2022 30;9:911333. Epub 2022 May 30.

Department of Cardiology, Peking University First Hospital, Beijing, China.

Background: Coexisting primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS) caused by bilateral adrenocortical adenomas have occasionally been reported. Precise diagnosis and treatment of the disease pose a challenge to clinicians due to its atypical clinical manifestations and laboratory findings.

Case Summary: A 49-year-old woman was admitted to our hospital due to fatigue, increased nocturia and refractory hypertension. Read More

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Conn's Syndrome: An Unusual Cause of Periodic Paralysis.

Cureus 2022 May 10;14(5):e24880. Epub 2022 May 10.

Internal Medicine, Hospital Beatriz Ângelo, Loures, PRT.

Primary hyperaldosteronism, also known as Conn's syndrome, is characterized by an independent and excessive aldosterone production in the adrenal cortex, causing hypernatremia, arterial hypertension, and, in some cases, potentially severe hypokalemia can occur. We report a case of a 45-year-old Caucasian woman, with a history of obesity and hypertension, who presented to the emergency room with a four-week evolution history of myalgia and ascending muscle weakness eventually resulting in tetraparesis. The initial blood analysis showed severe hypokalemia (1. Read More

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A novel mutation of gene causing Gitelman syndrome.

SAGE Open Med Case Rep 2022 7;10:2050313X221102294. Epub 2022 Jun 7.

Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

A 48-year-old patient with a history of diabetes mellitus, presented to a surgical ward with abdominal pain. She was found to have hypokalemia. Her younger sister had passed away due to sudden cardiac death at the age of 25 years. Read More

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Vaping tetrahydrocannabinol unmasks Brugada pattern and induces ventricular fibrillation in Brugada syndrome: a case report.

Eur Heart J Case Rep 2022 Jun 6;6(6):ytac200. Epub 2022 Jun 6.

Department of Cardiology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Background: Fever, alcohol, and sodium channel blockers can unmask Brugada pattern and may also induce arrhythmias in Brugada syndrome. We report a case of unmasked Type-1 Brugada pattern presenting with ventricular fibrillation that was induced by a tetrahydrocannabinol vaping.

Case Summary: A 48-year-old male with a past medical history of hypertension treated with hydrochlorothiazide and back pain controlled with tetrahydrocannabinol vaping presented with sudden cardiac arrest from ventricular fibrillation, which was terminated with defibrillation. Read More

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Successful resolution of ectopic Cushing syndrome by minimally invasive thoracoscopic resection of the neuroendocrine tumor of the thymus: a rare case report.

BMC Surg 2022 Jun 11;22(1):226. Epub 2022 Jun 11.

Department of Thoracic Surgery, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.

Background: Ectopic Cushing syndrome (ECS) is a sporadic condition. Even uncommon is an ECS that derives from a carcinoid tumor of the thymus. These tumors may pose several diagnostic and therapeutic conundrums. Read More

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The role of routine laboratory tests after unilateral total knee arthroplasty.

BMC Musculoskelet Disord 2022 Jun 10;23(1):564. Epub 2022 Jun 10.

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Jiangxi, People's Republic of China.

Background: Recent studies suggest that routine laboratory tests are not required within 1 day after partial knee arthroplasty. In this study, we evaluated the utility of routine postoperative laboratory tests after initial unilateral total knee arthroplasty (TKA) in an Asian population. In addition, we explored risk factors associated with abnormal test results. Read More

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Treatment Outcomes Among Pregnant Patients With Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis.

JAMA Netw Open 2022 Jun 1;5(6):e2216527. Epub 2022 Jun 1.

Telethon Kids Institute, Nedlands, Western Australia, Australia.

Importance: The management of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes.

Objective: To systematically synthesize treatment outcomes and adverse events among pregnant patients with MDR-TB.

Data Sources: PubMed, Scopus, Web of Science, and ProQuest were searched from the inception of each database through August 31, 2021. Read More

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Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled.

Eur Heart J 2022 Jun 10. Epub 2022 Jun 10.

Baylor Heart and Vascular Institute Dallas, TX, USA.

Aims: Hyperkalaemia frequently leads to interruption and discontinuation of neurohormonal antagonists, which may worsen heart failure prognosis. Some studies suggested that sodium-glucose cotransporter 2 inhibitors reduce hyperkalaemia, an effect that may have important clinical implications. This analysis evaluates the effect of empagliflozin on the occurrence of hyper- and hypokalaemia in HF. Read More

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[A case of familial hypokalemia periodic palsysis with gene and pedigree analysis].

Zhonghua Nei Ke Za Zhi 2022 Jun;61(6):682-684

Department of Endocrinology,Hainan General Hospital, Haikou 570311, China.

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