13,824 results match your criteria Hypokalemia


Novel SLCO2A1compound heterozygous mutation causing primary hypertrophic osteoarthropathy with Bartter-like hypokalemia in a Chinese family.

J Endocrinol Invest 2019 Apr 19. Epub 2019 Apr 19.

Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, 100730, China.

Purpose: Primary hypertrophic osteoarthropathy (PHO) is an inherited disease characterized by digital clubbing, periostosis and pachydermia with defects in the degradation of prostaglandin E2 (PGE2). Mutations in SLCO2A1 gene-encoding prostaglandin transporter (PGT) resulted in PHO, autosomal recessive 2 (PHOAR2). The spectrum of mutations and variable clinical complications of PHOAR2 has been delineated. Read More

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http://dx.doi.org/10.1007/s40618-019-01048-zDOI Listing

Therapeutic Challenges in Management of Severe Acidosis and Profound Hypokalemia in Pediatric Diabetic Ketoacidosis.

Glob Pediatr Health 2019 8;6:2333794X19840364. Epub 2019 Apr 8.

Beaumont Health System, Royal Oak, MI, USA.

Profound hypokalemia in the presence of diabetic ketoacidosis (DKA) is life-threatening condition predisposing patients to cardiac arrhythmias and potentially death. Rarely do patients present with profound hypokalemia (serum K level <2.5 mEq/L). Read More

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http://journals.sagepub.com/doi/10.1177/2333794X19840364
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http://dx.doi.org/10.1177/2333794X19840364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454640PMC
April 2019
1 Read

Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.

Biomed Res Int 2019 13;2019:9721781. Epub 2019 Mar 13.

Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater than 10-fold elevation of 24-hour urinary free cortisol level. Read More

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http://dx.doi.org/10.1155/2019/9721781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436364PMC

Digenetic inheritance of SLC12A3 and CLCNKB genes in a Chinese girl with Gitelman syndrome.

BMC Pediatr 2019 Apr 18;19(1):114. Epub 2019 Apr 18.

The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Background: Gitelman syndrome (GS) is an autosomal recessive disorder and mild variant of classic Bartter syndrome. The latter is caused by defects in the genes CLCNKB and/or CLCNKA (chloride voltage-gated channel Ka and Kb). Patients with GS usually have loss-of-function mutations in SLC12A3. Read More

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http://dx.doi.org/10.1186/s12887-019-1498-3DOI Listing
April 2019
2 Reads

[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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April 2019
2 Reads

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing
April 2019
1 Read

Barbiturate-induced dyskalaemia in patients with traumatic brain injury patient.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Nerancy Neuro-Intensive Care Unit, University of Virginia, Charlottesville, Virginia, USA.

A young man with severe traumatic brain injury and refractory intracranial hypertension was treated with a barbiturate coma. A rare side effect of barbiturates is dyskalaemia. The dyskalaemia presented with acute hypokalaemia that quickly became hyperkalaemia. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22811
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http://dx.doi.org/10.1136/bcr-2018-228119DOI Listing
April 2019
1 Read

A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome.

Iran J Kidney Dis 2019 Mar;13(2):132-133

University of Health Sciences, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

McKittrick-Wheelock syndrome is a rare complication of rectosigmoid villous adenoma leading to secretory diarrhea, prerenal acute kidney injury and severe fluid and electrolyte imbalances. There are about 50 cases reported in literature. We represent a case of 71 year-old patient with persistant chronic diarrhea, prerenal azotemia, severe hypokalemia, and hyponatremia. Read More

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March 2019
2 Reads

Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial.

Lancet Oncol 2019 Apr 12. Epub 2019 Apr 12.

BC Cancer Agency-Vancouver Centre, Vancouver, BC, Canada.

Background: In the interim analyses of the LATITUDE study, the addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT) led to a significant improvement in overall survival and radiographic progression-free survival compared with placebos plus ADT in men with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (mCSPC). Here, we present long-term survival outcomes and safety of abiraterone acetate plus prednisone and ADT from the final analysis of the LATITUDE study.

Methods: This is a multicentre, randomised, double-blind, phase 3 trial done at 235 sites in 34 countries. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30082-8DOI Listing
April 2019
1 Read

A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.

Am J Hypertens 2019 Apr 12. Epub 2019 Apr 12.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Liddle syndrome (LS) is an autosomal dominant disorder caused by single-gene mutations of the epithelial sodium channel (ENaC). It is characterized by early onset hypertension, spontaneous hypokalemia and low plasma renin and aldosterone concentrations. In this study, we reported an LS pedigree with normokalemia resulting from a novel SCNN1G frameshift mutation. Read More

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http://dx.doi.org/10.1093/ajh/hpz053DOI Listing
April 2019
2 Reads

MST3 (Mammalian Ste20 Kinase 3) is involved in ENaC-mediated hypertension.

Am J Physiol Renal Physiol 2019 Apr 10. Epub 2019 Apr 10.

school of pharmacy, China medical university, Taichung, Taiwan, Taiwan.

Liddle syndrome is an inherited form of human hypertension caused by increasing ENaC (epithelial sodium channel) expression. Increased Na retention through ENaC with subsequent volume expansion causes hypertension. In addition to ENaC, NKCC (Na-K-Cl cotransporter) and NCC (Na-Cl symporter) are responsible for Na reabsorption in the kidneys. Read More

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http://dx.doi.org/10.1152/ajprenal.00455.2018DOI Listing
April 2019
4 Reads

Thyrotoxic periodic paralysis with ventricular tachycardia.

J Electrocardiol 2019 Apr 4;54:93-95. Epub 2019 Apr 4.

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

A 47-year-old man presented to our emergency department (ED) with limbs weakness for 2 h. His heart rate was 127 beats per minute and blood pressure was 95/49 mm Hg. He found weakness of limbs after 4-h sleep. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.04.001DOI Listing
April 2019
2 Reads

Development and evaluation of taste masked dry syrup formulation of potassium chloride.

AAPS Open 2019 22;5(1). Epub 2019 Jan 22.

3Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii Hilo, 200 W. Kawili Street, Hilo, HI 96720 USA.

Potassium chloride (KCl) syrup is widely used for the oral treatment of the hypokalemia. However, it is associated with unacceptable taste. In the present study, we sought to develop a palatable and easy to reconstitute KCl dry syrup as a commercially viable alternative to currently available KCl syrup. Read More

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http://dx.doi.org/10.1186/s41120-019-0030-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421559PMC
January 2019
1 Read

Systematic review of the clinical outcomes of mineralocorticoid receptor antagonist treatment versus adrenalectomy in patients with primary aldosteronism.

Hypertens Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Yufu City, Oita, 879-5593, Japan.

Primary aldosteronism (PA) is the most common cause of secondary hypertension. The aim of this study was to review the clinical outcomes after mineralocorticoid receptor (MR) antagonist treatment versus adrenalectomy treatment in patients with PA. Relevant medical literature from PubMed, the Cochrane Library, and the ICHUSHI database from 1985 to August 2017 was reviewed. Read More

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http://dx.doi.org/10.1038/s41440-019-0244-4DOI Listing
April 2019
1 Read

Effectiveness and safety of electrical cardioversion for acute-onset atrial fibrillation in the emergency department: a real-world 10-year single center experience.

Clin Exp Emerg Med 2019 Mar 28;6(1):64-69. Epub 2019 Mar 28.

Emergency Department, University Hospital of Parma, Parma, Italy.

Objective: Despite limited evidence, electrical cardioversion of acute-onset atrial fibrillation (AAF) is widely performed in the emergency department (ED). The aim of this study was to describe the effectiveness and safety of electrical cardioversion of AAF performed by emergency physicians in the ED.

Methods: All episodes of AAF electrically cardioverted in the ED were retrieved from the database for a 10-year period. Read More

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http://dx.doi.org/10.15441/ceem.17.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453693PMC
March 2019
2 Reads

Partial Fanconi Syndrome Induced by Ifosfamide.

Cureus 2019 Jan 23;11(1):e3947. Epub 2019 Jan 23.

Internal Medicine, Kettering Medical Center, Dayton, USA.

Several commonly used chemotherapeutic agents, antibiotics, antivirals, and antiepileptic medications can cause partial or full Fanconi syndrome, disorders which can generally be described as transport defects in the proximal renal tubule, associated with non-anion gap metabolic acidosis. Fanconi syndrome is underreported and therefore often missed in the clinical setting. Herein, we present a case report that details the course of a 64-year-old female with a history of stage IV undifferentiated pleomorphic sarcoma who after her sixth chemotherapeutic cycle (adriamycin, ifosfamide, and mesna) developed severe hypokalemia, hypophosphatemia, and proteinuria without glycosuria, eventually diagnosed with partial Fanconi syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433442PMC
January 2019
1 Read

Evaluation of Hyponatremia in Ischemic Stroke Patients in a Tertiary Care Hospital of Karachi, Pakistan.

Cureus 2019 Jan 21;11(1):e3926. Epub 2019 Jan 21.

Internal Medicine, Dow University of Health Sciences, Karachi, USA.

Introduction Electrolyte disturbances are commonly found in acute stroke settings. Hypernatremia, hyponatremia and hypokalemia are the commonest types of electrolyte disturbances. Data on electrolyte changes in neurological disorders like stroke is insufficient in Asia. Read More

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http://dx.doi.org/10.7759/cureus.3926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433087PMC
January 2019
2 Reads

Benign Acute Childhood Myositis: A Benign Disease that Mimics More Severe Neuromuscular Disorder.

J Pediatr Neurosci 2018 Oct-Dec;13(4):404-409

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Context: Proximal lower limb weakness presenting acutely with or without preceding fever is a strong mimic of Guillain-Barré syndrome (GBS). Benign acute childhood myositis (BACM) forms an important differential diagnosis in such cases.

Aim: To characterize the clinical and laboratory findings of patients with BACM for better understanding of the disease. Read More

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http://dx.doi.org/10.4103/JPN.JPN_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413614PMC
April 2019
8 Reads

Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia.

Authors:
Yu Du Yi Mou Jin Liu

Exp Ther Med 2019 Apr 21;17(4):3222-3232. Epub 2019 Feb 21.

Department of Anesthesia and Intensive Care, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Stringent regulations have been established for the intravenous administration of potassium to avoid hyperkalemia in the clinic. The standard approach, however, often does not work well for treating severe hypokalemia. In the present study, a rabbit model of hyperkalemia was used to develop an tailored rapid potassium supplementation strategy and the effectiveness and safety of this new strategy were assessed. Read More

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http://dx.doi.org/10.3892/etm.2019.7292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434384PMC
April 2019
2 Reads

Acquired Gitelman Syndrome Associated with Systemic Sclerosis.

Cureus 2019 Jan 20;11(1):e3923. Epub 2019 Jan 20.

Internal Medicine, Einstein Medical Center, Philadelphia, USA.

Gitelman syndrome is an inherited renal disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria and metabolic alkalosis linked to the genes encoding the thiazide sensitive NaCl cotransporter (NCCT) located on the distal convoluted tubule of the kidney. It usually presents in late childhood or early adulthood with electrolyte abnormalities resembling chronic thiazide diuretic use. Acquired Gitelman syndrome is a very rare disorder mostly associated with Sjogren's syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430306PMC
January 2019
4 Reads

Clinical and Etiological Spectrum of Hypokalemic Periodic Paralysis in a Tertiary Care Hospital in Pakistan.

Cureus 2019 Jan 19;11(1):e3921. Epub 2019 Jan 19.

Nephrology, Tulane University School of Medicine, New Orleans, USA.

Introduction Hypokalemic periodic paralysis (HPP) is characterized by muscle weakness secondary to low serum potassium levels. It may be primary in origin or there may be secondary causes like thyrotoxic periodic paralysis, renal or suprarenal causes, or non-renal causes like gastroenteritis. Aim To study the etiology, clinical manifestations, and outcome after therapy of patients with hypokalemic paralysis. Read More

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http://dx.doi.org/10.7759/cureus.3921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426562PMC
January 2019
2 Reads

A family with Liddle's syndrome caused by a new c.1721 deletion mutation in the epithelial sodium channel β-subunit.

Exp Ther Med 2019 Apr 13;17(4):2777-2784. Epub 2019 Feb 13.

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China.

A 19-year-old male with early refractory hypertension, hypokalemia, serum potassium level of 3.4 mmol/l and hypoaldosteronemia was indicated in the present study. According to the results of laboratory tests and examinations, the patient was suspected of having Liddle's syndrome (LS). Read More

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http://dx.doi.org/10.3892/etm.2019.7270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425271PMC
April 2019
1 Read

[Corticosurrenaloma: an exceptional cause of primary hyperaldosteronism].

Pan Afr Med J 2018 27;31:60. Epub 2018 Sep 27.

Service d'Endocrinologie et Médecine Interne, Hôpital Tahar Sfar, Mahdia, Tunisie.

Corticosurrenaloma is a rare malignant tumor of the adrenal gland that often secretes corticosteroids, sex steroids and precursors. Aldosterone-producing corticosurrenaloma is very rare, accounting for 1 case/10million inhabitants. We report the case of a 38-year old man presenting with severe arterial hypertension associated with deep hypokalaemia (2. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.60.16973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431414PMC
April 2019
1 Read

Avoiding the Need for Bowel Anastomosis during Pelvic Exenteration-Urinary Sigmoid or Descending Colon Conduit-Short and Long Term Complications.

Urology 2019 Mar 25. Epub 2019 Mar 25.

Department of Urology, Emory University School of Medicine, Atlanta, GA; Winship Cancer Institute, Emory Healthcare, Atlanta, GA.

Objective: To educate surgeons of distal colon urinary diversion as an alternative to ileal conduit. To assess peri-operative outcomes of distal colon conduit in pelvic exenteration including conduit-related, gastrointestinal, infectious, metabolic, and wound complications within 30 days, 31-89 days, and greater than 90 days from the time of surgery.

Materials & Methods: Forty-one patients who underwent distal colon urinary diversion for malignancy, fistula, or neurogenic bladder were identified in our IRB approved database from 1/2005 - 7/2017 RESULTS: Twenty-six (63. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193030
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http://dx.doi.org/10.1016/j.urology.2019.03.015DOI Listing
March 2019
6 Reads

Hyperkalemia Is Associated With Increased Mortality Among Unselected Cardiac Intensive Care Unit Patients.

J Am Heart Assoc 2019 Apr;8(7):e011814

3 Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mayo Clinic Rochester MN.

Background Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit ( CICU ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected CICU patients. Methods and Results We retrospectively reviewed a historical cohort of 9681 CICU patients admitted from January 2007 to December 2015. Read More

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http://dx.doi.org/10.1161/JAHA.118.011814DOI Listing
April 2019
4 Reads

The outcome of two pregnancies in a patient with Gitelman syndrome: case report and review of the literature.

J Matern Fetal Neonatal Med 2019 Mar 28:1-3. Epub 2019 Mar 28.

a Department of Obstetrics and Gynecology , Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University , Fuzhou , China.

We report a case of a 30-year-old woman who was first found to have a persistently low serum potassium level at 26 years of age during her first pregnancy. Genetic test of SLC12A3 confirmed Gitelman syndrome. The patient remained asymptomatic and had two deliveries following spontaneous labor. Read More

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http://dx.doi.org/10.1080/14767058.2019.1598359DOI Listing
March 2019
2 Reads

Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.

Ectopic ACTH syndrome (EAS) due to a prostate small cell carcinoma (SCC) is very rare with only 26 cases reported to date and has a poor prognosis. We here describe another case of this disorder that was clinically typical based on prior reports as it showed hypercortisolemia and severe hypokalemia with multiple metastasis. However, our current case of prostate SCC causing EAS is the first to display negative immunostaining for ACTH despite detectable POMC mRNA expression in the primary lesion. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0563DOI Listing

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.

Int J Endocrinol 2019 19;2019:7159696. Epub 2019 Feb 19.

Key Laboratory of Endocrinology of National Health Commission of People's Republic of China, Beijing 100730, China.

Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China.

Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Read More

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http://dx.doi.org/10.1155/2019/7159696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399544PMC
February 2019
2 Reads
1.515 Impact Factor

[Accidentally diagnosed distal renal tubular acidosis with nephrocalcinosis - a case report].

Pol Merkur Lekarski 2019 Mar;46(273):146-148

Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.

Distal renal tubular acidosis is a defect of acidification of urine in distal tubule. Full-blown form is characterized by polyuria, growth deficiency, nephrolithiasis or nephrocalcinosis. Mutations in genes encoding Cl-/HCO3 - exchanger (autosomal dominant) or H+-ATPase (autosomal recessive) are the most frequent in children. Read More

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March 2019
1 Read

Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms.

Semin Diagn Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, United States. Electronic address:

Neuroendocrine paraneoplastic syndromes (PNS) consist of metabolic disorders that accompany benign and malignant neoplasms but remain unrelated to mass effects or invasion by the primary tumor or its metastases. The underlying pathogenesis responsible for PNS usual clinical presentation rely on aberrant production of protein hormones, proteins and other substances by the tumor. Prompt recognition of characteristic signs and symptoms combined with serological identification of key substances may result in early diagnosis of PNS and its underlying malignancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570193002
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http://dx.doi.org/10.1053/j.semdp.2019.03.002DOI Listing
March 2019
10 Reads

Clinical, laboratory and ultrasonographic findings in 87 cows with type-4 abomasal ulcer.

BMC Vet Res 2019 Mar 25;15(1):100. Epub 2019 Mar 25.

Department of Farm Animals, Vetsuisse-Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057, Zurich, Switzerland.

Background: This study evaluated the clinical, laboratory, ultrasonographic and pathological findings in 87 cows aged 2 to 10 years (4.5 ± 1.5 years) with type-4 abomasal ulcer. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-019-1844-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434897PMC
March 2019
4 Reads

Reversible iatrogenic paraparesis secondary to masked hypokalaemia in thrombocytosis-associated pseudohyperkalaemia.

BMJ Case Rep 2019 Mar 22;12(3). Epub 2019 Mar 22.

Sanz Medical Centre, Laniado Hospital, Netanya, Israel.

An elderly patient who presented with recent recurrent falls was admitted, reporting inability to stand and recent acute diarrhoeal illness. Paraparesis was diagnosed but extensive investigations did not elucidate its cause. He had atherosclerotic cardiac and vascular disease, diabetes, hypertension, chronic kidney disease and pancreatectomy/splenectomy for a lesion that turned out to be benign. Read More

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http://dx.doi.org/10.1136/bcr-2018-228058DOI Listing
March 2019
1 Read

Dengue fever presenting as quadriparesis due to hypokalaemia: a rare presentation.

BMJ Case Rep 2019 Mar 23;12(3). Epub 2019 Mar 23.

Medicine, Aga Khan University, Karachi, Pakistan.

Dengue is one of the leading causes of arthropod borne viral haemorrhagic fever. Majority of the times, it clinically manifests as fever, arthralgia and rash; however, we present a case of a young man who presented with progressively increasing weakness of all four limbs. Initial investigations showed low potassium, hence he was managed as hypokalaemic periodic paralysis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227981DOI Listing
March 2019
2 Reads

Hypokalemic Periodic Paralysis- the importance of patient education.

Rom J Intern Med 2019 Jan 1. Epub 2019 Jan 1.

Division of Community Internal Medicine, Mayo Clinic, San Pablo Rd, Jacksonville, Florida, USA.

Hypokalemic periodic paralysis (HOKPP) is a rare neuromuscular disorder caused by altered transport of cellular potassium that leads to significant muscle weakness of the extremities. Paralytic attacks are induced by a drop in the serum potassium level and have been associated with specific triggers. This case describes a 21-year-old male who has had recurrent presentations of acute paralytic attacks following vigorous physical activity. Read More

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http://dx.doi.org/10.2478/rjim-2019-0004DOI Listing
January 2019
3 Reads

Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study.

JAMA Netw Open 2019 Mar 1;2(3):e191054. Epub 2019 Mar 1.

Kenya Medical Research Institute Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.

Importance: Mortality among African children hospitalized with severe malnutrition remains high, with sudden, unexpected deaths leading to speculation about potential cardiac causes. Malnutrition is considered high risk for cardiac failure, but evidence is limited.

Objective: To investigate the role of cardiovascular dysfunction in African children with severe, acute malnutrition (SAM). Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1054DOI Listing
March 2019
1 Read

A case of severe metabolic acidosis during pregnancy.

Clin Case Rep 2019 Mar 7;7(3):550-552. Epub 2019 Feb 7.

Department of Medicine (Nephrology) Penn State Milton S. Hershey Medical Centre Hershey Pennsylvania.

Renal tubular acidosis (RTA) is a disorder that impairs renal acid-base regulation leading to normal anion gap metabolic acidosis. It is rare to encounter this entity during pregnancy. Pregnancy can worsen renal tubular acidosis (RTA) due to the physiological changes that happen during pregnancy. Read More

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http://dx.doi.org/10.1002/ccr3.2042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406225PMC
March 2019
2 Reads

Association of abnormal serum electrolyte levels with hypertension in a population with high salt intake.

Public Health Nutr 2019 Mar 21:1-11. Epub 2019 Mar 21.

2Department of Cardiology,The First Hospital of China Medical University,155 Nanjing Bei Street, Shenyang110001,Liaoning,People's Republic of China.

Objective: The present epidemiological study aimed to evaluate the association of serum electrolyte levels with hypertension in a population with a high-salt diet.

Design: Secondary analysis of epidemiology data from the Northeast China Rural Cardiovascular Health Study conducted in 2012-2013. Blood pressure and hypertension status were analysed for association with serum sodium, potassium, chloride, total calcium, phosphate and magnesium levels using regression models. Read More

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http://dx.doi.org/10.1017/S1368980019000260DOI Listing
March 2019
1 Read
2.679 Impact Factor

[CME Answers: 'Evaluation of Hypokalemia', Praxis No. 3].

Praxis (Bern 1994) 2019;108(4):291-292

1 Medizinische Klinik, Kantonsspital Frauenfeld.

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http://dx.doi.org/10.1024/1661-8157/a003192DOI Listing
January 2019
2 Reads

Apparent Mineralocorticoid Excess in the Pediatric Population: Report of a Novel Pathogenic Variant of the 11β-HSD2 Gene and Systematic Review of the Literature.

Pediatr Endocrinol Rev 2019 Mar;16(3):335-358

Division of Pediatric Endocrinology, Baystate Children's Hopsital, USA.

Apparent mineralocorticoid excess (AME) is a rare inherited disorder caused by pathogenic variants in the 11β-HSD2 gene resulting in a deficiency of the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme catalyzing the conversion of cortisol to its inactive metabolite, cortisone. Impaired cortisol metabolism results in a mineralocorticoid excess-like state presenting as low renin, low aldosterone hypertension (HTN) and hypokalemia. Typically, AME is diagnosed in early childhood. Read More

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http://dx.doi.org/10.17458/per.vol16.2019.act.mineralocorticoidDOI Listing
March 2019
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An update on the medical consequences of anorexia nervosa.

Curr Opin Pediatr 2019 Mar 14. Epub 2019 Mar 14.

GMCCLINICS and Medical Department of the Eating Disorder Unit at The American Centre of Psychiatry and Neurology ACPN, Dubai, United Arab Emirates.

Purpose Of Review: The diagnosis of anorexia nervosa is associated with the highest mortality rate of any psychiatric disorder, mainly caused by medical complications.The purpose of this article is to review the common medical consequences of anorexia nervosa focusing on the special considerations related to children and adolescents and recent updates on the pathophysiology of these complications and their prognosis significance.

Recent Findings: The main findings were related to the diagnostic and prognostic value of hypokalaemia, QTc prolongation, hypoglycaemia and orthostatic changes. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000755DOI Listing
March 2019
5 Reads

READY: relative efficacy of loop diuretics in patients with chronic systolic heart failure-a systematic review and network meta-analysis of randomised trials.

Heart Fail Rev 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiology, Angiology, and Pulmonology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

The majority of patients with chronic heart failure (HF) receive long-term treatment with loop diuretics. The comparative effectiveness of different loop diuretics is unknown. We searched PubMed, clinicaltrials. Read More

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http://dx.doi.org/10.1007/s10741-019-09771-8DOI Listing
March 2019
3 Reads

Ranolazine, ACE Inhibitors, and Angiotensin Receptor Blockers.

Am J Med 2019 Mar 11. Epub 2019 Mar 11.

Johns Hopkins University, Towson, MD 21204.

Background: Ranolazine is an anti-angina agent with many metabolites creating the potential for off-target effects. FDA reviews sometimes contain clinically relevant data not found in other sources.

Methods: We reanalyzed data in an FDA review of the placebo-controlled MERLIN trial of ranolazine to display differences in adverse event rates graphically. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.02.032DOI Listing
March 2019
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Hyperglycemia and Hypokalemia in a 16-Year-Old Overweight Female Patient Misdiagnosed with Cushing Syndrome at First and Ultimately Diagnosed with Carney Complex Proven by PRKAR1A Gene Test: a Case Report and Literature Review.

Clin Lab 2019 Mar;65(3)

Background: Here we report on a 16-year-old female patient with typical Cushingoid features who was admitted because of purple striae, menostasis, and microsomia for 1 year, and laboratory tests showed hyperglycemia and hypokalemia.

Methods: For diagnosis, we employed a hormone test, abdominal and pituitary computed tomography scan, ultrasonography to detect endocrine and cardiocutaneous lesions. DNA sequencing to detect PRKAR1A gene mutation to make differential diagnosis for Cushing Syndrome. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180805DOI Listing
March 2019
4 Reads

Nail clubbing in laxative abuse: case report and review of the literature.

J Eat Disord 2019 5;7. Epub 2019 Mar 5.

3Department of Renal medicine, Gosford Hospital, Gosford, Australia.

Background: The link between clubbing and laxative abuse has been reported several times in the literature, in all cases in young females. The nature of this relationship is not understood.

Case: A young female, with no history of hepatic, pulmonary or malignant disease was found to have nail clubbing in the context of laxative abuse. Read More

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https://jeatdisord.biomedcentral.com/articles/10.1186/s40337
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http://dx.doi.org/10.1186/s40337-019-0236-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399833PMC
March 2019
7 Reads

Gitelman Syndrome: A Rare Cause of Seizure Disorder and a Systematic Review.

Case Rep Med 2019 5;2019:4204907. Epub 2019 Feb 5.

Resident Physician, Abington Hospital-Jefferson Health, Abington, PA, USA.

Gitelman syndrome is one of the few inherited causes of metabolic alkalosis due to salt losing tubulopathy. It is caused by tubular defects at the level of distal convoluted tubules, mimicking a thiazide-like tumor. It usually presents in late childhood or in teenage as nonspecific weakness, fatigability, polyuria, and polydipsia but very rarely with seizures. Read More

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http://dx.doi.org/10.1155/2019/4204907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379858PMC
February 2019
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Acute barium poisoning in a dog after ingestion of handheld fireworks (party sparklers).

J Vet Emerg Crit Care (San Antonio) 2019 Mar 12;29(2):201-207. Epub 2019 Mar 12.

U-Vet Animal Hospital, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Australia.

Objective: To report a case of acute barium poisoning in a dog subsequent to ingestion of a common handheld pyrotechnic (sparkler).

Case Summary: A 5-year-old female neutered German Shorthaired Pointer presented with acute onset of generalized flaccid muscle paralysis and fasciculations, ptyalism, and an irregular heart rhythm. Marked hypokalemia (1. Read More

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http://dx.doi.org/10.1111/vec.12820DOI Listing
March 2019
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Fosfomycin for injection (ZTI-01) vs Piperacillin-Tazobactam (PIP-TAZ) for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP): ZEUS, A Phase 2/3 Randomized Trial.

Clin Infect Dis 2019 Mar 6. Epub 2019 Mar 6.

Chief Scientific Officer, Zavante Therapeutics, Inc., San Diego, CA.

Background: ZTI-01 (fosfomycin for injection) is an epoxide antibiotic with a differentiated mechanism of action (MOA) inhibiting an early step in bacterial cell wall synthesis. ZTI-01 has broad in vitro spectrum of activity, including multidrug-resistant Gram-negative pathogens, and is being developed for treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) in the United States.

Methods: Hospitalized adults with suspected or microbiologically confirmed cUTI/AP were randomized 1:1 to 6 g ZTI-01 q8h or 4. Read More

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http://dx.doi.org/10.1093/cid/ciz181DOI Listing
March 2019
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Hypokalemia Caused by Quetiapine and Risperidone Treatment in Schizophrenia: A Case Report.

Shanghai Arch Psychiatry 2018 Jun;30(3):204-206

First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hypokalemia can cause abnormalities in multiple systems. Long term use of antipsychotic medications can lead to electrolyte imbalance, including hypokalemia. We report a 49-year-old female patient with schizophrenia who developed hypokalemia after oral quetiapine and risperidone treatments. Read More

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http://dx.doi.org/10.11919/j.issn.1002-0829.217168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410402PMC
June 2018
5 Reads

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study.

Lancet Oncol 2019 Apr 8;20(4):518-530. Epub 2019 Mar 8.

Sarah Cannon Research Institute, Nashville, TN, USA; Tennessee Oncology, PLLC, Nashville, TN, USA.

Background: Therapies targeting HER2 have improved clinical outcomes in HER2-positive breast and gastric cancers, and are emerging as potential treatments for HER2-positive metastatic colorectal cancer. MyPathway evaluates the activity of targeted therapies in non-indicated tumour types with potentially predictive molecular alterations. We aimed to assess the activity of pertuzumab and trastuzumab in patients with HER2-amplified metastatic colorectal cancer. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30904-5DOI Listing
April 2019
9 Reads