14,417 results match your criteria Hypokalemia


Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?

Authors:
Taylor C Wallace

J Am Coll Nutr 2020 Jul 10:1-9. Epub 2020 Jul 10.

Think Healthy Group, Washington, DC, USA.

Background: In December 2019, the viral pandemic of respiratory illness caused by COVID-19 began sweeping its way across the globe. Several aspects of this infectious disease mimic metabolic events shown to occur during latent subclinical magnesium deficiency. Hypomagnesemia is a relatively common clinical occurrence that often goes unrecognized since magnesium levels are rarely monitored in the clinical setting. Read More

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http://dx.doi.org/10.1080/07315724.2020.1785971DOI Listing

Deferasirox-induced liver injury and Fanconi syndrome in a beta-thalassemia major male.

BMJ Case Rep 2020 Jul 9;13(7). Epub 2020 Jul 9.

Gastroenterology and Hepatology Department, Northern Health, Epping, Victoria, Australia.

A 33-year-old male presenting with subacute abdominal pain was found to have hyperbilirubinaemia, hypokalaemia and hyponatraemia. This was in the setting of transitioning between deferasirox iron chelator formulations, from dispersible tablets to film-coated tablets for ongoing treatment of chronic iron overload secondary to transfusion requirement for beta-thalassemia major. A liver biopsy demonstrated acute cholestasis with patchy confluent hepatocellular necrosis and mild to moderate microvesicular steatosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-234542DOI Listing

A novel homozygous mutation (p.N958K) of SLC12A3 in Gitelman syndrome is associated with endoplasmic reticulum stress.

J Endocrinol Invest 2020 Jul 8. Epub 2020 Jul 8.

Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

Purpose: Gitelman syndrome (GS) is an autosomal recessive renal tubular disease that arises as a consequence of mutations in the SLC12A3 gene, which codes for an Na-Cl cotransporter (NCC) in distal renal tubules. This study was designed to explore the mutations associated with GS in an effort to more fully understand the molecular mechanisms governing GS.

Methods: We analyzed SLC12A3 mutations in a pedigree including a 42-year-old male with GS as well as four related family members over three generations using Sanger and next generation sequencing approaches. Read More

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http://dx.doi.org/10.1007/s40618-020-01329-yDOI Listing

Omeprazole-induced hypomagnesaemia, causing renal tubular acidosis with hypokalaemia, hypocalcaemia, hyperlactacidaemia and hyperammonaemia.

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Internal Medicine, Ako City Hospital, Ako, Hyogo, Japan.

A 72-year-old Japanese man treated with omeprazole for 11 years was admitted due to loss of consciousness and muscle weakness. Wolff-Parkinson-White syndrome-induced tachycardia was considered as the cause of syncope. His blood examination revealed rhabdomyolysis, hypokalaemia, hypomagnesaemia, hypocalcaemia, hyperlactacidaemia, hyperammonaemia and high-anion-gap metabolic acidosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-235385DOI Listing

Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment.

Hypertension 2020 Aug 8;76(2):432-441. Epub 2020 Jul 8.

Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan (T.T., H.K.).

The SPRINT (Systolic Blood Pressure Intervention Trial) study reported that intensive blood pressure (BP) treatment with a systolic BP target of <120 mm Hg decreased the risks of cardiovascular events. However, it remains unknown whether specific medications can further improve cardiovascular outcome in patients receiving intensive BP treatment. This study examined whether thiazide use improves cardiovascular outcome in patients receiving intensive BP treatment. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15154DOI Listing

Clinical characteristics of concurrent primary aldosteronism and renal artery stenosis: A retrospective case-control study.

Clin Exp Hypertens 2020 Jul 8:1-6. Epub 2020 Jul 8.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China.

Background: Rare cases of concurrent primary aldosteronism (PA) and renal artery stenosis (RAS) have been reported.

Methods: In this retrospective case-control study, we selected a cohort of 10 PA with RAS patients and a control group of 20 PA without RAS patients from January 1, 2006, to January 1, 2016.

Results: All patients presented with refractory hypertension, and a nonstatistically significant trend toward lower mean serum potassium was seen in the PA with RAS group (p =. Read More

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http://dx.doi.org/10.1080/10641963.2020.1790586DOI Listing

[Hypokalemia with pseudo-hyperaldosteronism: Is it Lidl® syndrome?]

Nephrol Ther 2020 Jul 3. Epub 2020 Jul 3.

Division of nephrology, Rennes University Hospital, 2, rue Henri-Le-Guilloux, 35000 Rennes, France; Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR 1085, 9, avenue du Professeur-Léon-Bernard, 35000 Rennes, France.

Introduction: Intoxication induced by glycyrrhizin is a common cause of hypokalaemia by pseudo-hyperaldosteronism.

Observation: We hereby present the observation of a 68-year old patient hospitalised following a full hip-prosthesis operation after a deep hypokalaemia at 2.5mM was observed, with ECG signs (flat T waves and appearance of U waves). Read More

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http://dx.doi.org/10.1016/j.nephro.2020.03.008DOI Listing

Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts.

Medicine (Baltimore) 2020 Jul;99(27):e20931

Department of Internal Medicine C, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Various psychotropic drugs may affect the hematological and biochemical profiles of plasma and its metabolism. Carbamazepine, the most well-known psychotropic drug, can cause substantial hyponatremia. Methylphenidate, a piperidine derivative structurally related to amphetamines, acts as a central nervous system stimulant. Read More

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http://dx.doi.org/10.1097/MD.0000000000020931DOI Listing

Persistent cardiac arrest caused by profound hypokalaemia after large-dose insulin injection in a young man with type 1 diabetes mellitus: successful rescue with extracorporeal membrane oxygenation and subsequent ventricular assist device.

Cardiovasc J Afr 2020 Jul 6;31:1-4. Epub 2020 Jul 6.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Email:

A 28-year-old man who had a history of type 1 diabetes mellitus with poor medication compliance was referred to the emergency department of our institute with suspected diabetic ketoacidosis. The patient developed sudden cardiac arrest following continuous insulin administration. Laboratory data revealed severe hypokalaemia. Read More

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http://dx.doi.org/10.5830/CVJA-2020-018DOI Listing

Risk factors associated with 30-day hospital readmission after carotid endarterectomy.

Vascular 2020 Jul 5:1708538120937955. Epub 2020 Jul 5.

Division of Vascular Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.

Objective: The current study evaluated all-cause 30-day readmissions after carotid endarterectomy.

Methods: Patients undergoing carotid endarterectomy were selected from the Cerner Health Facts® database using ICD-9-CM procedure codes from their index admission. Readmission within 30 days of discharge was determined. Read More

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http://dx.doi.org/10.1177/1708538120937955DOI Listing

Hypokalemia After Rituximab Administration in Steroid-Dependent Nephrotic Syndrome: A Case Report.

Front Pharmacol 2020 17;11:915. Epub 2020 Jun 17.

Nephrology and Dialysis Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

The monoclonal antibody rituximab is a commonly used steroid sparing agent for steroid-dependent idiopathic nephrotic syndrome of childhood. With this brief report, we describe the first case of symptomatic hypokalemia after intravenous rituximab administration in a young woman. The sudden onset of dizziness and palpitation prompted acute life-threatening hypokalemia recognition by blood gas analysis and electrocardiography. Read More

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http://dx.doi.org/10.3389/fphar.2020.00915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311762PMC

Two novel mutations in the gene leading to classic Bartter syndrome presenting as syncope and hypertension in a 13-year-old boy.

BMJ Case Rep 2020 Jul 5;13(7). Epub 2020 Jul 5.

School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam.

Classic Bartter syndrome is a rare condition caused by mutations in the gene and characterised by metabolic alkalosis, hypokalaemia, hyper-reninaemia and hyperaldosteronism. Early signs and symptoms usually occur before a child's sixth birthday and include polyuria and developmental delay. We treated a 13-year-old Vietnamese boy with this syndrome presenting with atypical presentations including syncope and hypertension, but normal growth and development. Read More

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http://dx.doi.org/10.1136/bcr-2019-233872DOI Listing

A guide to establishing a hyperthermic intraperitoneal chemotherapy program in gynecologic oncology.

Gynecol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Division of Gynecologic Oncology, Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Desk A81, 9500 Euclid Avenue, Cleveland, OH 44195, United States of America.

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) may be used to treat peritoneal based malignancies, such as epithelial ovarian cancer (EOC). Despite results of clinical trials supporting an increasing indication for HIPEC in EOC, concerns have existed regarding morbidity and challenges with initiating HIPEC at an institutional level. The objective of this review is to describe evidence-based recommendations to guide implementation of a HIPEC program, following our experience at a high-volume tertiary care center. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.487DOI Listing

[Bartter-Gitelman syndromes].

Nephrol Ther 2020 Jul 1. Epub 2020 Jul 1.

Département de génétique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Centre de Référence de maladies rénales rares de l'enfant et de l'adulte (MARHEA), Paris, France.

Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartter syndrome is defined by polyhydramnios and an infantile polyuria with severe dehydration whereas classic Bartter syndrome appears during childhood or adulthood. Read More

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http://dx.doi.org/10.1016/j.nephro.2020.06.001DOI Listing

Comparative Analysis of Clinical and Biochemical Profile of Exertional Heat Related Illness Among Cadets in a Military Training Centre in South India: A Single Centre Experience.

J Assoc Physicians India 2020 Apr;68(4):29-31

Senior Advisor Medicine and Oncology, Command Hospital, Bengaluru, Karnataka.

Background: Heat-related illnesses includes a range of manifestation starting from minor illness like heat rashes/ heat cramps to more complicated illness like heat exhaustion and the most severe heat stroke. Often derangements in biochemical parameters including metabolic acidosis, respiratory alkalosis, electrolytes, transminitis and renal dysfunction are noticed in patients with heat stroke. Objective: The present study was an attempt to compare the clinical and changes in biochemical parameters in exertional heat exhaustion and heat stroke patients among cadets from a military training centre admitted to an Armed forces hospital in South India. Read More

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The Problems with Risk Prediction during an Emergency Medical Admission Using Laboratory Data - Evidence from Potassium.

Acute Med 2019 ;18(1):20-26

Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland.

Background: The prediction of clinical outcomes using biochemical markers is an important tool.

Methods: We calculated a risk score for all emergency admissions 2002-2017. We related potassium and mortality in a multivariable fractional polynomial model. Read More

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January 2019

Ectopic Cushing syndrome in Colombia.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Neoplasia Endocrina y Trastornos Hormonales, Universidad de Texas, MD Anderson Cancer Center, Houston Texas.

Objective: The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients.

Materials And Methods: Records of patients with ECS from 1986 to 2017 were retrospectively reviewed; patients with a diagnosis of adrenal or pituitary Cushing syndrome (CS) were excluded.

Results: Fourteen patients with ECS were analyzed in this study. Read More

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http://dx.doi.org/10.20945/2359-3997000000271DOI Listing

Relationship between serum potassium level and survival outcome in out-of-hospital cardiac arrest using CAPTURES database of Korea: Does hypokalemia have good neurological outcomes in out-of-hospital cardiac arrest?

Adv Clin Exp Med 2020 Jun;29(6):727-734

Department of Emergency Medicine, Kyung Hee University Hospital at Gangdong, South Korea.

Background: Sudden cardiac arrest is a major cause of death worldwide. Serum potassium level is an initial laboratory test that serves as part of an electrolyte panel easily obtainable by most emergency departments (EDs).

Objectives: To evaluate the relationship between serum potassium level and the survival outcome for out-of-hospital cardiac arrest (OHCA) patients. Read More

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http://dx.doi.org/10.17219/acem/122178DOI Listing

Endocrine and Metabolic Manifestations of Snakebite Envenoming.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Department of Endocrinology, Manipal Hospital, New Delhi, India.

Snake envenoming is a neglected, public health problem in tropical and subtropical regions. Local tissue necrosis, neurotoxic, and hemo-vasculotoxic effects are well-recognized features, whereas the endocrine and metabolic derangements are not as well known. In addition to contributing to morbidity, some of these manifestations can be potentially life-threatening if not recognized early. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0161DOI Listing

Hyperkalaemia and hypokalaemia outpatient management: a survey of 500 French general practitioners.

ESC Heart Fail 2020 Jun 29. Epub 2020 Jun 29.

Université de Lorraine, Inserm, Centre d'Investigations Cliniques, Plurithématique 1433, and Inserm 1116 DCAC, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Aims: How general practitioners (GPs) manage dyskalaemia is currently unknown. This study aimed at describing GP practices regarding hypokalaemia or hyperkalaemia diagnosis and management in their outpatients.

Methods And Results: A telephone survey was conducted among French GPs with a 20-item questionnaire (16 closed-ended questions and 12 open-ended questions) regarding their usual management of hypokalaemia or hyperkalaemia patients, both broadly and more specifically in patients with heart failure and/or chronic kidney disease and/or in patients treated with angiotensin-converting enzyme/angiotensin receptor blockers or mineralocorticoid receptor antagonists. Read More

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http://dx.doi.org/10.1002/ehf2.12834DOI Listing

A Case of Gitelman Syndrome Diagnosed with Anorexia Nervosa in a Psychiatry Clinic.

Turk Psikiyatri Derg 2020 ;31(1):69-73

Anorexia nervosa is a disorder that is characterized by excessive preoccupation with body weight and shape, and conscious attempts to stay in low weight due to fear of weight gain. Vomiting, one of the METHODS used by anorexia nervosa patients to stay in low weight, is one of the most important causes of hypokalemia. Diuretics and diarrhea are other common causes of hypokalemia. Read More

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January 2020

Refeeding syndrome in small ruminants receiving parenteral nutrition.

J Vet Intern Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Clinical Studies-New Bolton Center (Luethy, Stefanovski, Sweeney), School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Background: Small ruminants presented to tertiary care facilities commonly suffer from severe protein-calorie malnutrition. Some of these patients require parenteral nutrition (PN; amino acids and dextrose with or without lipids) during hospitalization. Refeeding syndrome, a potentially fatal shift of electrolytes seen in malnourished patients during refeeding, may occur. Read More

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http://dx.doi.org/10.1111/jvim.15840DOI Listing

First Onset Hypokalemic Periodic Paralysis Following Surgery for Myxopapillary Ependymoma, Case Report.

World Neurosurg 2020 Jun 22. Epub 2020 Jun 22.

George Emil Palade University of Medicine, Pharmacy, Science and Technology, Tîrgu MureȘ, Romania; Department of Neurology, Tîrgu MureȘ County Clinical Emergency Hospital, Tîrgu MureȘ, Romania.

Background: Hypokalemic periodic paralysis is a rare skeletal muscle channelopathy characterized by intermittent episodes of acute flaccid paralysis with associated hypokalaemia. We present here the case of a first-onset hypokalemic periodic paralysis triggered by a lumbar spinal surgery for tumor resection.

Case Description: A 37-years old male, without any known prior medical conditions who presented with a first-onset attack of hypokalemic paralysis 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.109DOI Listing

Metabolic Complications Occur More Frequently in Older Patients Receiving Parenteral Nutrition.

Nutr Clin Pract 2020 Aug 24;35(4):627-633. Epub 2020 Jun 24.

Department of Pharmacy, Cooper University Hospital, Camden, New Jersey, USA.

Background: The European Society for Clinical Nutrition and Metabolism Guidelines for Parenteral Nutrition in Geriatric Patients state metabolic complications are more frequent in elderly patients. However, literature provides limited information about metabolic complications in older patients receiving parenteral nutrition (PN). Consequently, the purpose of this study was to compare the development of metabolic complications in older vs younger patients receiving PN. Read More

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http://dx.doi.org/10.1002/ncp.10499DOI Listing
August 2020
2.058 Impact Factor

Cushing syndrome cardiomyopathy: an unusual manifestation of small-cell lung cancer.

ESC Heart Fail 2020 Jun 23. Epub 2020 Jun 23.

Department of Medicine, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030-2202, USA.

Cushing syndrome is a rare cause of dilated cardiomyopathy and heart failure with reduced ejection fraction. Cases describing this association are scarce. We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia, severe hyperglycaemia, and uncontrolled hypertension who was found to have hypercortisolism secondary to an ectopic adrenocorticotropic hormone-secreting primary lung neoplasm. Read More

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http://dx.doi.org/10.1002/ehf2.12860DOI Listing

A Case of Severe Hypokalemia.

Am J Kidney Dis 2020 Jul;76(1):A9-A12

Rochester General Hospital, Rochester, NY; University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.12.020DOI Listing

A case report of three children with secondary hypertension caused by Liddle syndrome.

Clin Nephrol Case Stud 2020 29;8:37-40. Epub 2020 May 29.

Department of Pediatrics, University of Louisville, Louisville, KY, USA.

Background: Liddle syndrome is a monogenetic cause of early-onset hypertension that is associated with hypokalemia and metabolic alkalosis that is inherited in an autosomal dominant fashion with variable penetrance.

Case Presentation: We present a case report of three children seen at a tertiary children's hospital with varying severity of hypertension and electrolyte disturbances, who had genetic testing performed due to strong family history of hypertension. They were each subsequently found with the same genetic mutation of SCNN1B consistent with Liddle syndrome and started on epithelial sodium channel inhibitors with improvement in their blood pressure. Read More

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http://dx.doi.org/10.5414/CNCS109972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303542PMC

Electrolyte Abnormalities in Patients Presenting With Ventricular Arrhythmia (from the LYTE-VT Study).

Am J Cardiol 2020 May 15. Epub 2020 May 15.

Department of Medicine, Section of Cardiac Electrophysiology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. Electronic address:

Electrolyte abnormalities are a known trigger for ventricular arrhythmia, and patients with heart disease on diuretic therapy may be at higher risk for electrolyte depletion. Our aim was to determine the prevalence of electrolyte depletion in patients presenting to the hospital with sustained ventricular tachycardia or ventricular fibrillation (VT/VF) versus heart failure, and identify risk factors for electrolyte depletion. Consecutive admissions to a tertiary care hospital for VT/VF were identified between July 2016 and October 2018 using the electronic medical record and compared with an equal number of consecutive admissions for heart failure (CHF). Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.051DOI Listing

Short-term efficacy and safety of levosimendan in patients with chronic systolic heart failure.

Cardiovasc J Afr 2020 Jun 12;31:1-5. Epub 2020 Jun 12.

The Sixth Department of Cardiovascular Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Email:

The objective was to investigate and evaluate the short-term efficacy and safety of levosimendan in patients with chronic systolic heart failure. Forty-nine patients with chronic systolic heart failure during acute decompensation were randomly divided into a levosimendan group (26 cases) and a control group (23 cases). The control group received only routine treatment, while the levosimendan group received a levosimendan bolus with a load of 12 µg/kg, in addition to the same routine treatment as the control group. Read More

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http://dx.doi.org/10.5830/CVJA-2020-008DOI Listing

Adjusted tight control blood glucose management in diabetic patients undergoing on pump coronary artery bypass graft. A randomized clinical trial.

J Diabetes Metab Disord 2020 Jun 20;19(1):423-430. Epub 2020 Jan 20.

Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Many of the patients who are undergoing Coronary Artery Bypass Graft have diabetes mellitus or metabolic syndrome and are at risk for hyperglycemia events.

Objective: The present study aimed to compare conventional glucose control with adjusted tight control in patients undergoing on-pump CABG.

Methods: This double -blind randomized clinical trial study was conducted in Shiraz, Iran, from September 2017-March 2018. Read More

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http://dx.doi.org/10.1007/s40200-020-00494-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270305PMC

Hypokalemia Leading to Postoperative Critical Arrhythmias: Case Reports and Literature Review.

Cureus 2020 May 16;12(5):e8149. Epub 2020 May 16.

Surgery, Hamad Medical Corporation, Doha, QAT.

Perioperative arrhythmias can develop due to many reasons, rarely life-threatening, but hypokalemia plays an important role in their development. We report two cases of severe postoperative hypokalemia leading to ventricular fibrillation (VF). Case 1: A young healthy lady developed perioperative severe hypokalemia leading to repeated episodes of VF requiring cardiopulmonary resuscitation (CPR), direct current (DC) shock and anti-arrhythmic therapy, apart from rapid replacement of intravenous potassium. Read More

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http://dx.doi.org/10.7759/cureus.8149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294897PMC

[Diagnosis and Treatment of Primary Aldosteronism in West China Hospital of Sichuan University from 2009 to 2018].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 May;51(3):292-297

Adrenal Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To summary the clinical diagnosis and treatment of primary aldosteronism (PA) in West China Hospital (WCH) of Sichuan University during 2009-2018.

Methods: This study enrolled the patients diagnosed as PA and admitted in WCH of Sichuan University from January 2009 to December 2018. The information of the patients including epidemiological and clinical data, diagnosis and treatment as well as therapeutic outcomes were collected and analyzed. Read More

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http://dx.doi.org/10.12182/20200360108DOI Listing

The Case of Flecainide Toxicity: What to Look for and How to Treat.

J Emerg Med 2020 Jun 11. Epub 2020 Jun 11.

Department of Emergency Medicine, Beaumont Health, Royal Oak, Michigan.

Background: Flecainide is a class Ic antidysrhythmic agent used to prevent and treat both ventricular and supraventricular tachycardias, including atrial fibrillation, atrioventricular nodal re-entrant tachycardia, and Wolff-Parkinson-White syndrome. Flecainide can cause serious side effects, including cardiac arrest, dysrhythmias, and heart failure. Despite its growing use, the presenting signs and symptoms of flecainide toxicity are not familiar to most clinicians. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.052DOI Listing

Comparison of Platinum/S-1 and Platinum/5-Fluorouracil as First-Line Chemotherapy for Advanced Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis Based on Randomized Controlled Trials.

Chemotherapy 2020 Jun 12:1-10. Epub 2020 Jun 12.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Platinum/S-1 (PS) and platinum/5-fluorouracil (PF) as first-line chemotherapies are extensively used for the treatment of advanced gastric or gastroesophageal junction cancer (AGC); however, there is no definite consensus on which regimen is best. In our meta-analysis, we compared PS with PF in terms of their efficacy and safety in AGC patients.

Methods: PubMed, ScienceDirect, Web of Science, Scopus, Ovid MEDLINE, EMBASE, The Cochrane Library, Google Scholar, and CNKI were systematically searched for pertinent literature. Read More

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http://dx.doi.org/10.1159/000506671DOI Listing

Falsely Elevated Digoxin Levels in Patients on Enzalutamide.

Circ Heart Fail 2020 Jun 12:CIRCHEARTFAILURE120007008. Epub 2020 Jun 12.

Department of Pathology and Laboratory Medicine, Rush University Medical Center, Chicago, IL. (M.T.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007008DOI Listing

Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China.

JAMA Netw Open 2020 06 1;3(6):e2011122. Epub 2020 Jun 1.

Department of Microbiology, Wenzhou Municipal Centre for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.

Importance: Severe acute respiratory syndrome coronavirus 2 has caused a global outbreak of coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 binds angiotensin-converting enzyme 2 of the rennin-angiotensin system, resulting in hypokalemia.

Objective: To investigate the prevalence, causes, and clinical implications of hypokalemia, including its possible association with treatment outcomes, among patients with COVID-19. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.11122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290402PMC

Inhibition of K2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia.

Front Pharmacol 2020 20;11:749. Epub 2020 May 20.

Acesion Pharma, Copenhagen, Denmark.

Background: Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductance Ca-activated K-channels (K2) are a promising new atrial selective target for treatment of atrial fibrillation. Read More

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http://dx.doi.org/10.3389/fphar.2020.00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251152PMC

[Panic and pandemic: Review of the literature on the links between panic disorder and the SARS-CoV-2 epidemic].

Authors:
H Javelot L Weiner

Encephale 2020 Jun 21;46(3S):S93-S98. Epub 2020 May 21.

Clinique de psychiatrie, CHU de Strasbourg, Strasbourg, France; Laboratoire de psychologie des cognitions, université de Strasbourg, Strasbourg, France.

Although the "panic" word has been abundantly linked to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic in the press, in the scientific literature very few studies have considered whether the current epidemic could predispose to the onset or the aggravation of panic attacks or panic disorder. Indeed, most studies thus far have focused on the risk of increase and aggravation of other psychiatric disorders as a consequence of the SARS-CoV-2 epidemic, such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and generalized anxiety disorder (GAD). Yet, risk of onset or aggravation of panic disorder, especially the subtype with prominent respiratory symptoms, which is characterized by a fear response conditioning to interoceptive sensations (e. Read More

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http://dx.doi.org/10.1016/j.encep.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241353PMC

Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency.

CEN Case Rep 2020 Jun 6. Epub 2020 Jun 6.

Department of Nephrology, Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8102, Japan.

Bartter syndrome and Gitelman syndrome (GS) are autosomal recessive disorders usually caused by homozygous or compound heterozygous mutations in causative genes. In some patients, these two syndromes cannot be discriminated based on clinical features or mutation type; thus, a single disease concept, salt-losing tubulopathies (SLTs), has been used instead. Despite the existence of several SLT causative genes, cases of digenic heterozygous mutations in two different genes are extremely rare. Read More

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http://dx.doi.org/10.1007/s13730-020-00489-3DOI Listing

Antenatal Bartter Syndrome: A Case Report.

Mymensingh Med J 2020 Apr;29(2):469-472

Dr Mahboba Akther, Resident Phase-B, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Bartter syndrome is an autosomal recessive disorder manifested by a defect in sodium-potassium-chloride transport in the thick ascending limb of Henle with different genetic origins and molecular pathophysiology. Bartter syndrome usually a common disease in children and in early infancy presented with persistent polyuria and associated with dehydration, electrolyte imbalance, and failure to thrive. Though prompt diagnosis and proper treatment of Bartter syndrome may improve the outcome, some children will progress to renal failure. Read More

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Cystic Fibrosis Presenting as Pseudo-Bartter Syndrome: An Important Diagnosis that is Missed!

Indian J Pediatr 2020 Jun 5. Epub 2020 Jun 5.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Cystic fibrosis (CF), an autosomal recessive disorder, occurs due to mutations in CFTR gene resulting in impaired cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel function in various epithelia. In addition to the well-known pulmonary and pancreatic morbidities, CF is characterized by electrolyte and acid-base abnormalities- hypochloremia, hyponatremia, hypokalemia and metabolic alkalosis. These are collectively known as Pseudo-Bartter syndrome, as similar abnormalities are seen in Bartter syndrome- an inherited tubulopathy affecting thick ascending limb of loop of Henle. Read More

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http://dx.doi.org/10.1007/s12098-020-03342-8DOI Listing

Prevalence of primary aldosteronism in hypertensive kidney transplant recipients: A cross-sectional study.

Clin Transplant 2020 Jun 5:e13999. Epub 2020 Jun 5.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Due to high prevalence of primary aldosteronism (PA) in the general hypertensive population, and its association with worse cardiovascular and renal outcomes, the 2016 Endocrine Society Guidelines explicitly recognize PA as a major public health issue requiring urgent attention. Its prevalence in hypertensive kidney transplant recipients (KTRs) is unknown. In this cross-sectional study, we screened KTRs with hypertension who were on ≥4 antihypertensive medications, on 3 antihypertensive medications with BP ≥ 140/90, and on potassium supplements, or were hypokalemic. Read More

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http://dx.doi.org/10.1111/ctr.13999DOI Listing

Hypokalemic paralysis as an initial presentation of Sjogren syndrome.

Ann Afr Med 2020 Apr-Jun;19(2):147-149

Department of Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Sjogren syndrome (SS) is a systemic autoimmune disorder with predominant exocrine gland involvement leading to sicca symptoms. Among extraglandular manifestations, renal disease is the most common. Tubular interstitial nephritis and renal tubular acidosis (RTA) are the common presentations. Read More

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http://dx.doi.org/10.4103/aam.aam_34_19DOI Listing

Abnormalities of Potassium in Heart Failure: JACC State-of-the-Art Review.

J Am Coll Cardiol 2020 Jun;75(22):2836-2850

Université de Lorraine INSERM, Centre, d'Investigations Cliniques Plurithématique, Nancy, France.

Potassium (K) is the most abundant cation in humans and is essential for normal cellular function. Alterations in K regulation can lead to neuromuscular, gastrointestinal, and cardiac abnormalities. Dyskalemia (i. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.04.021DOI Listing

Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers.

Nutrients 2020 Jun 2;12(6). Epub 2020 Jun 2.

La Isla Network, 1441 L Street NW, Washington, DC 20005, USA.

Background: Chronic kidney disease of non-traditional origin (CKDnt) is common among Mesoamerican sugarcane workers. Recurrent heat stress and dehydration is a leading hypothesis. Evidence indicate a key role of inflammation. Read More

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http://dx.doi.org/10.3390/nu12061639DOI Listing

The hypokalemia mystery: distinguishing Gitelman and Bartter syndromes from 'pseudo-Bartter syndrome'.

Nephrol Dial Transplant 2020 Jun 3. Epub 2020 Jun 3.

Division of Nephrology and Hypertension, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1093/ndt/gfaa100DOI Listing

Lefamulin: The First Systemic Pleuromutilin Antibiotic.

Ann Pharmacother 2020 Jun 4:1060028020932521. Epub 2020 Jun 4.

Regis University School of Pharmacy, Denver, CO, USA.

To review the pharmacology, microbiology, efficacy, and safety of lefamulin. A literature search was performed using PubMed and Google Scholar (2010 to end-April 2020) with the search terms and . Other resources included abstracts presented at recent conferences, prescribing information, and the manufacturer's and Food and Drug Administration websites. Read More

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http://dx.doi.org/10.1177/1060028020932521DOI Listing

[Paraneoplastic Cushing's syndrome as cause of refractory hypokalemia].

Dtsch Med Wochenschr 2020 Jun 3;145(11):783-786. Epub 2020 Jun 3.

Abteilung für Endokrinologie, Diabetologie und Metabolismus, Medizinische Universitätsklinik, Kantonsspital Aarau, Schweiz.

History:  A 58-year-old man presented with refractory hypokalemia and rapid weight gain. On examination, he had high blood pressure, central obesity and bilateral pitting edema.

Findings And Diagnosis:  Biochemical tests showed hypokalemic metabolic alkalosis due to ACTH-dependent hypercortisolism. Read More

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http://dx.doi.org/10.1055/a-1163-9873DOI Listing