13,455 results match your criteria Hypokalemia


The Case | Severe hypokalemia complicated by a syncope.

Kidney Int 2018 Jul;94(1):225-226

Department of Nephrology, Cliniques Universitaires Saint Luc, Brussels, Belgium.

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Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome.

Gynecol Endocrinol 2018 Jun 22:1-3. Epub 2018 Jun 22.

b 2nd Department of Obstetrics and Gynecology , Aristotle University of Thessaloniki, Hippokration General Hospital , Thessaloniki , Greece.

Herbal supplements are widely used during pregnancy, although there are insufficient data regarding their efficacy and safety. Some of them have been associated with hypertension, including licorice, which induces the so called mineralocorticoid-excess syndrome, a clinical picture resembling to pseudohyperaldosteronism. This action is mediated via inhibition of 11-hydroxysteroid dehydrogenase type 2 (11-HSD2), leading to impaired inactivation of cortisol to cortisone, accumulation of cortisol, and finally to excessive mineralocorticoid activity, especially in the distal and cumulative tubule of kidneys. Read More

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A phase I study of LY3164530, a bispecific antibody targeting MET and EGFR, in patients with advanced or metastatic cancer.

Cancer Chemother Pharmacol 2018 Jun 20. Epub 2018 Jun 20.

Cancer Medicine Division, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.

Purpose: The phase I study characterized the safety, pharmacokinetics, anti-tumor activity, and recommended phase II dose/schedule of LY3164530 in patients with advanced or metastatic cancer.

Methods: Patients received LY3164530 on days 1 and 15 (Schedule 1: 300, 600, 1000, and 1250 mg) or Days 1, 8, 15, and 22 (Schedule 2: 500 and 600 mg) of each 28 days cycle. Dose escalation used a modified toxicity probability interval model. Read More

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A rare case of hypokalemia-induced rhabdomyolysis.

J Geriatr Cardiol 2018 Apr;15(4):321-324

Department of Cardiology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

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Bradykinin Stimulates Renal Na and K Excretion by Inhibiting the K Channel (Kir4.1) in the Distal Convoluted Tubule.

Hypertension 2018 Jun 18. Epub 2018 Jun 18.

From the Department of Physiology, Harbin Medical University, China (D.-D.Z., Y.X., H.Z., X.-W.G., X.-X.M., L.G., J.-L.W., X.-P.D., R.G.)

Stimulation of BK2R (bradykinin [BK] B2 receptor) has been shown to increase renal Na excretion. The aim of the present study is to explore the role of BK2R in regulating Kir4.1 and NCC (NaCl cotransporter) in the distal convoluted tubule (DCT). Read More

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June 2018
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Comparison of prognostic systems in cirrhotic patients with hepatic encephalopathy

Turk J Med Sci 2018 Jun 14;48(3):543-547. Epub 2018 Jun 14.

Background/aim: There are various scoring systems for evaluating prognosis in patients hospitalized in intensive care units (ICUs) with hepatic encephalopathy. These include the Child-Turcotte-Pugh (CTP) classification, Model for End-stage Liver Disease (MELD), chronic liver failure-sequential organ failure assessment (CLIF-SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II). In this study, we aimed to compare the various scoring systems to determine the best system for showing the prognosis of patients with a prior diagnosis of cirrhosis who were hospitalized for hepatic encephalopathy. Read More

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June 2018
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Hypokalemic Paralysis Due to Primary Sjogren Syndrome.

Authors:
Anuj Sarma

Indian J Endocrinol Metab 2018 Mar-Apr;22(2):287-289

Department of Anaesthesia and Critical Care, Down Town Hospital, Gauhati, Assam, India.

Sjögren syndrome is an autoimmune disorder characterized by lymphocytic infiltration of exocrine gland. The most common symptom by virtue of its involvement includes dryness of eyes, mouth, and parotid gland enlargement. However, the disease may be associated with extraglandular manifestation affecting multiple organs. Read More

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Thyrotoxic Hypokalemic Periodic Paralysis.

Indian J Crit Care Med 2018 May;22(5):378-380

Department of Medicine, KGMU, Lucknow, Uttar Pradesh, India.

Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia. Read More

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Refeeding syndrome: relevance for the critically ill patient.

Curr Opin Crit Care 2018 Jun 8. Epub 2018 Jun 8.

Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.

Purpose Of Review: To provide an overview of recent findings concerning refeeding syndrome (RFS) among critically ill patients and recommendations for daily practice.

Recent Findings: Recent literature shows that RFS is common among critically ill ventilated patients. Usual risk factors for non-ICU patients addressed on ICU admission do not identify patients developing RFS. Read More

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Bartter Syndrome Type 3: Phenotype-Genotype Correlation and Favorable Response to Ibuprofen.

Front Pediatr 2018 30;6:153. Epub 2018 May 30.

Department of Nephrology, Children's Hospital of Chongqing Medical University, Chongqing, China.

To investigate the phenotype-genotype correlation in different genetic kinds of Bartter syndrome type 3 in children. Clinical and genetic data of 2 patients with different mutations in Bartter syndrome type 3 was analyzed while the prognosis was compared after a 6-year follow-up or 2-year follow-up, respectively. Bartter syndrome is a kind of autosomal recessive inherited renal disorder. Read More

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Distal tubule basolateral potassium channels: cellular and molecular mechanisms of regulation.

Curr Opin Nephrol Hypertens 2018 Jun 11. Epub 2018 Jun 11.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Purpose Of Review: Multiple clinical and translational evidence support benefits of high potassium diet; however, there many uncertainties underlying the molecular and cellular mechanisms determining effects of dietary potassium. Kir4.1 and Kir5. Read More

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Cushing's syndrome caused by ACTH-producing thymic typical carcinoid with local invasion and regional lymph node metastasis: a case report.

Surg Case Rep 2018 Jun 11;4(1):55. Epub 2018 Jun 11.

Division of General Thoracic Surgery, Department of Surgery, Faculty of Medicine, Tottori University, 36-1, Nishi-cho, Yonago, 683-8504, Japan.

Background: Ectopic ACTH-producing thymic carcinoid tumors are rare, but often behave aggressively with local invasion and distant metastasis. We herein report a case of ACTH-producing thymic typical carcinoid tumor with lymph node metastasis treated by surgery and postoperative radiation therapy.

Case Presentation: A 61-year-old woman was admitted to be evaluated for hypoglycemia and hypokalemia. Read More

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June 2018
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ANNALS EXPRESS: Does thyrotoxic periodic paralysis have a genetic predisposition? A case report.

Ann Clin Biochem 2018 Jan 1:4563218785395. Epub 2018 Jan 1.

AMNCH Tallaght Hospital.

Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism where increased influx of potassium into skeletal muscle cells leads to profound hypokalaemia and paralysis. Most cases arise sporadically in Asians however it is being increasingly reported in Caucasians. TPP is regarded as a channelopathy where a genetic and/or acquired defect in the sodium-potassium (Na+/K+-ATPase) pump renders it more sensitive to excess thyroid hormone in susceptible individuals. Read More

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January 2018
2 Reads

Systolic heart failure in a patient with primary aldosteronism.

BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.

Endocrinology, St. Francis Medical Center, Trenton, New Jersey, USA.

A 53-year-old African man with a 25-year history of uncontrolled hypertension and systolic heart failure presented with an acute congestive heart failure exacerbation. He was found to have severe hypokalaemia, so additional testing was performed, and primary aldosteronism was confirmed. CT scan showed a 1. Read More

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June 2018
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Dangerous mistake: an accidental caffeine overdose.

BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.

Department of Internal Medicine, Centro Hospitalar Barreiro Montijo EPE, Barreiro, Portugal.

Caffeine (1,3,7-trimethylxanthine) is a natural product commonly presented in food's composition, beverages and medicinal products. Generally, it is thought to be safe under normal dosage, yet it can be fatal in case of severe intoxication. We report a case of a healthy 32-year-old woman who went to the local emergency department (ED) 30 min after ingesting, accidentally, 5000 mg of anhydrous caffeine for a preworkout supplement. Read More

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June 2018
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Predictive Analytics for Identification of Patients at Risk for QT Interval Prolongation - A Systematic Review.

Pharmacotherapy 2018 Jun 8. Epub 2018 Jun 8.

Department of Pharmacy Practice, College of Pharmacy, Purdue University, Indianapolis, Indiana.

Prolongation of the heart rate-corrected QT (QTc) interval increases the risk for torsades de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors, which include female sex, older age, heart failure with reduced ejection fraction, hypokalemia, hypomagnesemia, concomitant administration of ≥ 2 QTc interval-prolonging medications, among others. Assessment and quantification of risk factors may facilitate prediction of patients at highest risk for developing QTc interval prolongation and TdP. Read More

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June 2018
2 Reads

Severe electrolytes disorders with the interstitial kidney alterations in the patient with the history of total thyroidectomy and parathyroidectomy: possible role of vitamin D deficiency.

Clin Case Rep 2018 Jun 6;6(6):983-989. Epub 2018 Apr 6.

Department of Diabetology & Endocrinology Kanazawa Medical University Uchinada Ishikawa 920-0293 Japan.

Vitamin D plays vital role for the health, and its deficiency has been implicated in the diverse pathological conditions such as hypomagnesemia and abnormal immune system. Here, we present a case of severe electrolytes disorders (hypokalemia and hypomagnesemia etc.) and kidney damages associated with vitamin D deficiency. Read More

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Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature.

World J Gastroenterol 2018 Jun;24(21):2320-2326

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C 8000, Denmark.

Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequestrants, such as colestyramine and colesevelam, which may be given in combination with the opioid receptor agonist loperamide. Some patients are refractory to conventional treatments. Read More

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Organotin Compounds Toxicity: Focus on Kidney.

Front Endocrinol (Lausanne) 2018 22;9:256. Epub 2018 May 22.

Laboratory of Endocrinology and Cellular Toxicology, Department of Morphology, Federal University of Espirito Santo, Vitoria, Brazil.

Organotin compounds (OTs) are synthetic persistent organometallic xenobiotics widely used in several commercial applications. They exert well-described harmful effects in brain, liver, adipose tissue, and reproductive organs, as they are endocrine-disrupting chemicals (EDCs), but the effects in the kidneys are less known. The kidneys are especially vulnerable to environmental contaminants because they are a metabolizing site of xenobiotics, therefore, pollutants can accumulate in renal tissue, leading to impaired renal function and to several renal abnormalities. Read More

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May 2018
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Differential diagnosis for chronic hypokalaemia.

BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.

Clinical Chemistry, Queen's Hospital, Burton on Trent, UK.

Doctors will often see patients with chronic hypokalaemia, frequently this is secondary to gastrointestinal losses, diuretics or renal disease. However, in this case report we review a rarer cause of chronic hypokalaemia-Gitelman syndrome (GS).GS is an uncommon genetic disorder which causes primary renal tubular hypokalaemic metabolic alkalosis with secondary hypomagnesaemia and hypocalciuria. Read More

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June 2018
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Gitelman syndrome and primary hyperparathyroidism: a rare association.

BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.

Department of Endocrinology, Hospital Curry Cabral, Lisboa, Portugal.

Gitelman syndrome(GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterised by hypokalaemia, hypomagnesaemia, hypocalciuria and secondary hyperaldosteronism. Hypercalcaemia due to hypocalciuria in these patients is extremely rare.A 25-year-old healthy woman was referred to the Endocrinology clinic for evaluation of persistent hypokalaemia. Read More

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June 2018
2 Reads

Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia.

Clin J Am Soc Nephrol 2018 Jun 5. Epub 2018 Jun 5.

Department of Nephrology, Geisinger Medical Center, Danville, Pennsylvania; and

Background And Objectives: Rapid correction of severe hyponatremia can result in serious neurologic complications, including osmotic demyelination. Few data exist on incidence and risk factors of rapid correction or osmotic demyelination.

Design, Setting, Participants, & Measurements: In a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017, we examined the incidence and risk factors of rapid correction and osmotic demyelination. Read More

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June 2018
2 Reads

Changing Management Guidelines in Thyrotoxic Hypokalemic Periodic Paralysis.

J Emerg Med 2018 Jun 2. Epub 2018 Jun 2.

Department of Emergency Medicine, University of California, San Diego, San Diego, California.

Background: Periodic paralysis is a rare complication of hyperthyroidism. Patients of East Asian descent are most commonly affected. Presentation is characterized by recurrent episodes of painless, abrupt-onset weakness, with laboratory evaluation characterized by profound hypokalemia. Read More

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June 2018
2 Reads

Bilateral Lower Extremity Paralysis in a Caucasian Male Presenting to the Emergency Department.

Case Rep Emerg Med 2018 15;2018:5740509. Epub 2018 May 15.

Little Rock Diagnostic Clinic, USA.

Reported is a case of a 39-year-old Caucasian man who presented to the emergency department with sudden onset bilateral lower extremity paralysis after consuming a large amount of carbohydrates and alcohol. A CT, MRI, and lumbar puncture were performed with negative results; lab results showed hyperthyroidism and hypokalemia. The patient was diagnosed with thyrotoxic periodic paralysis. Read More

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Two rare forms of congenital adrenal hyperplasia, 11β hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.

Hormones (Athens) 2018 Mar 16;17(1):127-132. Epub 2018 Apr 16.

Department of Endocrinology, Royal Darwin Hospital, Darwin, NT, Australia.

Background: Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder caused by deficiency of various enzymes responsible for adrenal steroidogenesis. 11-Beta-hydroxylase deficiency (11βOHD) and 17-hydroxylase/17,20-lyase deficiency (17OHD) are rare causes of CAH.

Methods/results: We hereby present a 65-year-old man with 11βOHD and a 33-year-old woman with 17OHD. Read More

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46,XY Disorder of Sex Development Caused by 17-Hydroxylase/17,20-Lyase Deficiency due to Homozygous Mutation of Gene: Consequences of Late Diagnosis.

Case Rep Endocrinol 2018 24;2018:2086861. Epub 2018 Apr 24.

Unit of Endocrinology, Università Cattolica del Sacro Cuore and Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

Context: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease due to specific enzyme deficiencies in the adrenal steroidogenesis pathway.

Case Description: A 40-year-old Chinese woman was referred to the Endocrine Unit for the work-up of a syndrome characterized by long-lasting and multidrug resistant high blood pressure, severe hypokalemia with metabolic alkalosis, and primary amenorrhea. The patient presented with sexual infantilism, lack of breast development, absence of axillary and pubic hair, tall stature, and slenderness. Read More

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Leveraging Clinical Time-Series Data for Prediction: A Cautionary Tale.

AMIA Annu Symp Proc 2017 16;2017:1571-1580. Epub 2018 Apr 16.

University of Michigan Computer Science and Engineering, Ann Arbor, MI.

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how the formulation can greatly impact both model performance and clinical utility. Read More

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Diverticular perforation: a fatal complication to forestall in Cushing's Syndrome.

J Clin Endocrinol Metab 2018 May 28. Epub 2018 May 28.

Diabetes, Obesity and Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Context: Patients taking exogenous glucocorticoids are at risk of gastrointestinal (GI) complications including peptic ulcer disease with perforation, and gastric bleeding. However, little is known about the GI co-morbidity in patients with endogenous hypercortisolemia.

Case Descriptions: We describe six patients with endogenous Cushing's Syndrome (CS) who developed sudden perforation of colonic diverticula requiring urgent exploratory laparotomy. Read More

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May 2018
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Hypokalemia in an end stage renal disease patient.

Am J Med 2018 May 26. Epub 2018 May 26.

Department of Medicine, University of Tennessee College of Medicine, Chattanooga. Electronic address:

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Consideration of the diagnosis of hypertension accompanied with hypokalaemia: monism or dualism?

J Int Med Res 2018 Jan 1:300060518768154. Epub 2018 Jan 1.

1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

This case report describes a 53-year-old male patient with persistent hypertension and hypokalaemia. Laboratory tests showed that the patient had hypokalaemia, hypocalcaemia and reduced urine calcium/creatinine. Levels of aldosterone and renin activity were increased significantly. Read More

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January 2018

[Analysis on clinical characteristics of 316 patients with hydrofluoric acid burns].

Zhonghua Shao Shang Za Zhi 2018 May;34(5):271-276

Department of Burns and Plastic Surgery, Zhejiang Quhua Hospital, Quzhou 324004, China.

To investigate the clinical characteristics of patients with hydrofluoric acid (HF) burns. Clinical data of 316 patients with HF burns admitted to Zhejiang Quhua Hospital from January 2004 to December 2016 were retrospectively analyzed. Patients were divided into non and mild poisoning group (NMP, =157), moderate poisoning group (MP, =120), and severe and fatal poisoning group (SFP, =39) based on the severity of poisoning. Read More

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Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization.

Authors:
Oleg E Osadchii

Scand Cardiovasc J 2018 May 25:1-9. Epub 2018 May 25.

a Department of Biomedical Sciences , University of Copenhagen , Copenhagen , Denmark.

Objectives: In normal conditions, sudden heart rate acceleration provokes a rapid reduction in ventricular action potential duration (APD). The protracted APD rate adaptation favors early afterdepolarizations and precipitates arrhythmia. Nevertheless, it is uncertain as to whether the rate-dependent changes of ventricular repolarization can be adversely modified by arrhythmogenic drugs (quinidine and procainamide) and hypokalemia, in comparison to the agents with safe therapeutic profile, such as lidocaine. Read More

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[Clinical research on perioperative restrictive fluid therapy combined with preoperative urination training in total hip arthroplasty].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Nov;31(11):1295-1299

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To evaluate the effectiveness and safety of restrictive fluid therapy combined with preoperative urination training during perioperative period in an enhanced recovery after surgery (ERAS) program for primary total hip arthroplasty (THA).

Methods: A retrospective study were conducted in 73 patients who underwent unilateral THA with liberal intravenous fluid therapy on the day of surgery between April 2015 and March 2016 (control group) and in 70 patients with restrictive fluid therapy and preoperative urination training between November 2016 and April 2017 (trial group). There was no significant difference in gender, age, weight, height, body mass index, primary disease, and complications between 2 groups ( >0. Read More

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November 2017

Puss Caterpillar Envenomation: Erucism Mimicking Appendicitis in a Young Child.

Pediatr Emerg Care 2018 May 23. Epub 2018 May 23.

Pediatrics, Section of Emergency Medicine, Baylor College of Medicine, Houston, TX.

A 4-year-old female presented to the emergency department with 2 days of abdominal pain, nausea, and vomiting. She was tachycardic and had abdominal tenderness. Laboratory studies revealed a leukocytosis, hypokalemia, and metabolic acidosis. Read More

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May 2018
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Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

J Med Chem 2018 Jun 24;61(11):4946-4960. Epub 2018 May 24.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

Inhibition of androgen biosynthesis is clinically effective for treating androgen-responsive prostate cancer. Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) required for androgen biosynthesis. However, abiraterone also causes hypertension, hypokalemia, and edema, likely due in part to off-target inhibition of another steroidogenic cytochrome P450, CYP21A2. Read More

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June 2018
2 Reads

Liddle's-like syndrome associated with nephrotic syndrome secondary to membranous nephropathy: the first case report.

BMC Nephrol 2018 May 23;19(1):122. Epub 2018 May 23.

Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, 1-4-1, Morioka, 020-0066, Japan.

Background: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria. Read More

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May 2018
2 Reads

[Bartter syndrome, severe rare orphan kidney disease: a step towards therapy through pharmacogenetic and epidemiological studies].

G Ital Nefrol 2018 May;35(3)

Dipartimento di Farmacia - Scienze del Farmaco, Università di Bari, Italia.

Bartter syndromes (BS) types 1-5 are rare salt-losing tubulopathies presenting with overlapping clinical phenotypes including marked salt wasting and hypokalemia leading to polyuria, polydipsia, volume contraction, muscle weakness and growth retardation. These diseases are due to an impairment of sodium, potassium, chloride reabsorption caused by mutations in genes encoding for ion channel or transporters expressed in specific nephron tubule segments. Particularly, BS type 3 is a clinically heterogeneous form caused by mutations in CLCNKB gene which encodes the ClC-Kb chloride channel involved in NaCl reabsorption in the renal tubule. Read More

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Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence.

Curr Probl Cardiol 2018 May 10. Epub 2018 May 10.

Department of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

Long QT syndrome (LQT) represents a heterogeneous family of cardiac electrophysiologic disorders characterized by QT prolongation and T-wave abnormalities on the electrocardiogram. It is commonly associated with syncope, however, sudden cardiac death can occur due to torsades de pointes. LQT is a clinical diagnosis and should be suspected in individuals on the basis of clinical presentation, family history and electrocardiogram characteristics. Read More

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Complete Hypokalemic Quadriparesis as a First Presentation of Sjögren Syndrome.

Can J Kidney Health Dis 2018 10;5:2054358118774536. Epub 2018 May 10.

Division of Nephrology and Immunology, Department Medicine, University of Alberta, Edmonton, Canada.

Rationale: We hope to increase awareness that hypokalemic paralysis may be the first presentation of Sjögren syndrome, for which potassium-sparing diuretics can be an effective adjunct to potassium replenishment.

Presenting Concerns: A 73-year-old female presented to a peripheral hospital with quadriparesis and a critically low serum potassium of 1.6 mmol/L with U waves on the electrocardiogram (ECG). Read More

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May 2018
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[Development of Ectopic Adrenocorticotropic Hormone Syndrome in a Patient with Prostate Cancer during Combined Androgen Blockade Therapy].

Hinyokika Kiyo 2018 Apr;64(4):175-179

The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.

A 74-year old man presented to us with difficulty urinating. The laboratory examinations revealed an elevated prostate-specific antigen (PSA) level. A prostate biopsy revealed prostate adenocarcinoma. Read More

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Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses.

J Vet Intern Med 2018 May 17. Epub 2018 May 17.

Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

Background: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics.

Objectives: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse.

Animals: Six healthy adult mares. Read More

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[Experimental research on individual-specific rapid potassium supplementation strategy for fatal severe hypokalemia].

Authors:
Yu Du Yi Mou Jin Liu

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 May;30(5):409-415

Department of Emergence, West China School of Public Health, No.4 West China Teaching Hospital, Sichuan University, Chengdu 610041, Sichuan, China (Du Y); Critical Care and Emergency Laboratory, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China (Mou Y, Liu J). Corresponding author: Du Yu, Email:

Objective: To explore the effectiveness and safety of the individual-specific rapid potassium supplementation strategy, and to provide experimental basis for treating fatal severe hypokalemia.

Methods: An acute fatal severe hypokalemia model was reproduced in 20 healthy adult Japanese big ear white rabbits with half lethal dose (LD50) of barium chloride (BaCl) solution 168 mg×5 mL×kg. The rabbits were divided into conventional potassium supplementation group and individual-specific rapid potassium supplementation group according to random number table method with 10 rabbits in each group. Read More

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Open-Label, Dose-Escalation, Phase 1 Study of Safety and Single and Multiple-Dose Pharmacokinetics of Dichlorphenamide in Healthy Volunteers.

Authors:
Fredric Cohen

Clin Pharmacol Drug Dev 2018 May 15. Epub 2018 May 15.

Strongbridge Biopharma, plc, Trevose, PA, USA.

Single-and multiple-dose pharmacokinetics and safety were investigated in this phase 1 study of dichlorphenamide, a carbonic anhydrase inhibitor approved in the United States for treatment of primary periodic paralysis. Dichlorphenamide was administered to 6 cohorts (n = 6 each) of healthy adults. Cohorts A through E received single doses of 25-400 mg followed by 50-800 mg/day in divided doses for 10 total doses. Read More

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Dual Paraneoplastic Endocrine Syndromes Heralding Onset of Extrapulmonary Small Cell Carcinoma: A Case Report and Narrative Review.

Front Endocrinol (Lausanne) 2018 18;9:170. Epub 2018 Apr 18.

Division of Endocrinology, Diabetes and Metabolism, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's and West Hospital Center, New York, NY, United States.

Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance.

Methods: Clinical, laboratory, imaging, and pathology data are presented. Read More

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April 2018
3 Reads

Clinical Studies of Interventions to Mitigate Cardiovascular Risk in Peritoneal Dialysis Patients.

Semin Nephrol 2018 May;38(3):277-290

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia; Centre for Kidney Disease Research, University of Queensland, Brisbane, Australia; Translational Research Institute, Brisbane, Australia. Electronic address:

Cardiovascular disease (CVD) is highly prevalent in the peritoneal dialysis (PD) population, affecting up to 60% of cohorts. CVD is the primary cause of death in up to 40% of PD patients in Australia, New Zealand, and the United States. Cardiovascular mortality rates are reported to be approximately 14 per 100 patient-years, which are 10- to 20-fold greater than those of age- and sex-matched controls. Read More

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Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol.

J Appl Physiol (1985) 2018 May 10. Epub 2018 May 10.

Institute for Health and Sport, Victoria University, Australia.

Intense exercise induces pronounced hyperkalemia, followed by transient hypokalemia in recovery. We investigated whether the β-agonist salbutamol attenuated the exercise-hyperkalemia, and exacerbated the post-exercise hypokalemia, and whether hypokalemia was associated with impaired cardiac repolarization (QT hysteresis). Eleven healthy adults participated in a randomized, counterbalanced, double-blind trial receiving either 1000 µg salbutamol (SAL) or placebo (PLAC) by inhalation. Read More

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Paediatric VIPoma: A Jamboree of Electrolytes.

Turk J Anaesthesiol Reanim 2018 Apr 29;46(2):158-160. Epub 2017 Nov 29.

Sher-I-Kashmir Institute of Medical Sciences and Associated Hospitals, Srinagar, India.

Vasoactive intestinal peptide secreting tumour (VIPoma) is a rare type of neuroendocrine tumour (NET), primarily located in the tail of pancreas. This type of tumour presents with myriad of metabolic and electrolyte misbalances in the preoperative period, mainly due to increased vasoactive intestinal peptide (VIP) levels. Perioperative management of patients with VIPoma is challenging, especially when dealing with paediatric patients. Read More

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Phase IB/II Study of Second-Line Therapy with Panitumumab, Irinotecan, and Everolimus (PIE) in Wild-Type Metastatic Colorectal Cancer.

Clin Cancer Res 2018 May 8. Epub 2018 May 8.

The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

Inhibition of mTOR in addition to EGFR may overcome resistance to EGFR inhibitors in metastatic colorectal cancer (mCRC). This phase Ib/II study evaluated the safety and efficacy of the combination of irinotecan, panitumumab, and everolimus. Patients with exon 2 wild-type (WT) mCRC following failure of fluoropyrimidine-based therapy received i. Read More

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