14,998 results match your criteria Hypokalemia


Exertional rhabdomyolysis in newly enrolled cadets of a military academy.

Muscle Nerve 2021 Jun 20. Epub 2021 Jun 20.

Medical School of Chinese PLA, Beijing, China.

Introduction/aims: Exertional rhabdomyolysis (ER) often occurs during prolonged intense exercise in hot environments, posing a threat to the health of military personnel. This study aimed to investigate possible risk factors for ER and provide further empirical data for prevention and clinical treatment strategies.

Methods: A retrospective investigation of 116 concurrent ER cases was conducted. Read More

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Patients with enteral nutrition at risk of refeeding syndrome show electrolyte abnormalities at admission in the Emergency Department.

Nutr Hosp 2021 Jun 21. Epub 2021 Jun 21.

Nutrition and Dietetics Division. Hospital de Clínicas de Porto Alegre. Universidade Federal do Rio Grande do Sul.

Introduction: Refeeding syndrome (RFS) is a metabolic complication in the initial phase of nutritional therapy (NT). Studies evaluating electrolyte abnormalities among patients at risk for RFS undergoing NT in the Emergency Department (ED) are scarce.

Objective: to explore the occurrence of electrolyte abnormalities among patients at risk for RFS with enteral nutrition admitted to the ED. Read More

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Partial versus total adrenalectomy for the treatment of unilateral aldosterone-producing adenoma: a systematic review and meta-analysis.

Updates Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Adrenalectomy is the first line of treatment in unilateral aldosterone-producing adenoma. Whether adrenalectomy should be performed using a cortex-sparing technique (partial adrenalectomy) or total adrenalectomy remains debatable. Therefore, this meta-analysis aims to evaluate the safety and effectiveness of partial adrenalectomy (PA) to total adrenalectomy (TA) by comparing perioperative and functional outcomes. Read More

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Liddle syndrome: A case report.

Med Clin (Barc) 2021 Jun 16. Epub 2021 Jun 16.

Department of Endocrinology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou Hospital Affiliated to Medical College of Zhejiang University, Huzhou City, Zhejiang Province, China. Electronic address:

Introduction: Liddle syndrome is an autosomal dominant hereditary disease caused by a single gene mutation. Typical clinical manifestations are early-onset hypertension and hypokalaemia and can be treated using ENaC blockers (amiloride and aminopterin).

Patients And Methods: This report describes a 17-year-old male with hypertension and hypokalaemia. Read More

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Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect.

BMJ Case Rep 2021 Jun 18;14(6). Epub 2021 Jun 18.

Department of Endocrinology, Copenhagen University Hospital, Herlev Hospital, 2730 Herlev, Denmark

We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Read More

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Ventricular tachycardia secondary to thyrotoxic periodic paralysis: A case report.

J Electrocardiol 2021 Jun 12;67:107-109. Epub 2021 Jun 12.

Department of Cardiology, Central Defense Hospital Gómez Ulla, Madrid, Spain.

Thyrotoxic periodic paralysis (TPP) is a rare but potentially life-threatening entity, which is characterized by sudden onset of muscle weakness and can in exceptional cases be associated with more severe symptoms, such as severe hypokalemia. We present the rare case of a young patient presenting with monomorphic ventricular tachycardia secondary to hypokalemia due to TPP. This case report highlights the importance of recognition of TPP as a rare cause of VT. Read More

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Hypokalaemic rhabdomyolysis as initial presentation of primary aldosteronism.

J R Coll Physicians Edinb 2021 06;51(2):149-152

Department of Endocrinology, Singapore General Hospital, Singapore.

Rhabdomyolysis is a clinical syndrome characterised by the destruction of skeletal muscle with subsequent leakage of intracellular muscle contents into the systemic circulation. It is commonly caused by trauma, strenuous physical activities, medications, illicit drug use, toxins, infections and electrolyte abnormalities. It can manifest as myalgia, muscle weakness, or myoglobinuria with or without acute kidney injury. Read More

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Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia.

Front Physiol 2021 26;12:651162. Epub 2021 May 26.

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.

Although plasma electrolyte levels are quickly and precisely regulated in the mammalian cardiovascular system, even small transient changes in K, Na, Ca, and/or Mg can significantly alter physiological responses in the heart, blood vessels, and intrinsic (intracardiac) autonomic nervous system. We have used mathematical models of the human atrial action potential (AP) to explore the electrophysiological mechanisms that underlie changes in resting potential (V) and the AP following decreases in plasma K, [K], that were selected to mimic clinical hypokalemia. Such changes may be associated with arrhythmias and are commonly encountered in patients (i) in therapy for hypertension and heart failure; (ii) undergoing renal dialysis; (iii) with any disease with acid-base imbalance; or (iv) post-operatively. Read More

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Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial.

J Vet Intern Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.

Background: Desoxycorticosterone pivalate (DOCP) is a commonly used mineralocorticoid replacement for dogs with primary hypoadrenocorticism (HA), but manufacturer-recommended dosing protocols can be cost-prohibitive. Recent reports also have raised concerns that label dose protocols could be excessive.

Objective: To investigate the relative efficacy and adverse effects of 2 DOCP dosages in dogs with primary glucocorticoid and mineralocorticoid deficient HA. Read More

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Primary Hyperaldosteronism and Renal Medullary Nephrocalcinosis: A Controversial Association.

Oman Med J 2021 May 31;36(3):e266. Epub 2021 May 31.

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir, India.

Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5-10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest causes of nephrocalcinosis are hyperparathyroidism, distal renal tubular acidosis, and medullary sponge kidney. Read More

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Results of a Gene Panel Approach in a Cohort of Patients with Incomplete Distal Renal Tubular Acidosis and Nephrolithiasis.

Kidney Blood Press Res 2021 Jun 9:1-6. Epub 2021 Jun 9.

U.O.S. Terapia Conservativa della Malattia Renale Cronica, U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of urinary acidification resulting in metabolic acidosis, hypokalemia, and inappropriately elevated urine pH. If not treated, this chronic condition eventually leads to nephrocalcinosis, nephrolithiasis, impaired renal function, and bone demineralization. dRTA is a well-defined entity that can be diagnosed by genetic testing of 5 genes known to be disease-causative. Read More

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A Case Report of Recurrent Hypokalemia During Pregnancies Associated With Nonaldosterone-Mediated Renal Potassium Loss.

Can J Kidney Health Dis 2021 28;8:20543581211017424. Epub 2021 May 28.

Medical University of South Carolina, College of Medicine, Charleston, SC, USA.

Rationale: Geller et al reported a rare mutation in the mineralocorticoid receptor (MR) resulting in constitutive MR activity. Progesterone, normally an MR antagonist, acts as a potent agonist with this mutation. Progesterone levels can increase 100-fold during pregnancy and thus lead to increased MR activity in this setting, resulting in hypertension (HTN) and hypokalemia during pregnancy and resolution of hypokalemia after delivery. Read More

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Correcting hypokalaemia in a paediatric patient with Bartter syndrome through oral dose of potassium chloride intravenous solution.

SAGE Open Med Case Rep 2021 30;9:2050313X211019789. Epub 2021 May 30.

Al Adan Paediatric Pharmacy, Kuwait-Al Adan Joint Hospital, Kuwait Hospital, Sabah Al Salem, Kuwait.

Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalaemia. Hypokalaemia is defined as low serum potassium concentration ˂3.5 mmol/L, which may lead to arrhythmia and death if left untreated. Read More

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[Analysis of clinical features and genetic variants among 12 children with Gitelman syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jun;38(6):526-530

Department of Endocrinology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

Objective: To summarize clinical manifestations and results of genetic testing in 12 children with Gitelman syndrome (GS).

Methods: Clinical data of the children was collected. Whole exome sequencing(WES) was carried out to screen potential variants of genomic DNA. Read More

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Anesthetic management of child with Gitelman Syndrome: case report.

Braz J Anesthesiol 2021 Jun 3. Epub 2021 Jun 3.

Hospital Senhora da Oliveira, Guimarães, Portugal.

Gitelman syndrome is a rare autosomal recessive inherited disease that affects the thiazidesensitive sodium-chloride cotransport channels and the magnesium channels in the distal convoluted tubule, leading to hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. There is no cure for this condition and supportive treatment relies on ionic supplementation and symptom management. Literature regarding the anesthetic approach is scarce. Read More

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Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):508-510

Montefiore Nyack Hospital, Nyack, New York, United States.

Chronic ingestion of licorice is known to cause numerous metabolic and electrolyte disturbances. Severe hyponatremia, hypertension, and hypokalemia as well as metabolic alkalosis are amongst the most common consequences of chronic ingestion resulting in an apparent mineralocorticoid excess (AME). Treatment predominantly consists of cessation of licorice ingestion, potassium replenishment and aldosterone antagonists. Read More

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The Clinical Decision Support System AMPEL for Laboratory Diagnostics: Implementation and Technical Evaluation.

JMIR Med Inform 2021 Jun 3;9(6):e20407. Epub 2021 Jun 3.

Institute of Laboratory Medicine, Clinical Chemistry und Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany.

Background: Laboratory results are of central importance for clinical decision making. The time span between availability and review of results by clinicians is crucial to patient care. Clinical decision support systems (CDSS) are computational tools that can identify critical values automatically and help decrease treatment delay. Read More

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Three Novel Homozygous Mutations of the Gene in a Gitelman Syndrome Patient.

Int J Gen Med 2021 24;14:1999-2002. Epub 2021 May 24.

Department of Endocrinology, The Peoples Hospital of Guangxi Zhuang Autonomous Region, Guangxi, People's Republic of China.

Aim: Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis. In this study, we investigated the clinical presentation and sequenced 26 exons of gene in a patient with a clinical suspicion of GS.

Methods: Clinical work-up including clinical examination, electrocardiography (ECG), chest X-ray, bone mineral density (BMD), and ultrasound examination was conducted and all exons of gene were analyzed by whole-exome sequencing. Read More

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Epidemiology, prognosis and management of potassium disorders in Covid-19.

Rev Med Virol 2021 Jun 2:e2262. Epub 2021 Jun 2.

Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Coronavirus disease (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently the largest health crisis facing most countries. Several factors have been linked with a poor prognosis for this disease, including demographic factors, pre-existing comorbidities and laboratory parameters such as white blood cell count, D-dimer, C-reactive protein, albumin, lactate dehydrogenase, creatinine and electrolytes. Electrolyte abnormalities particularly potassium disorders are common among Covid-19 patients. Read More

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Incidence of Refeeding Syndrome in Pediatric Inpatients at the US-Mexico Border.

South Med J 2021 Jun;114(6):351-355

From the Paul L. Foster School of Medicine, Texas Tech University Health Science Center at El Paso, El Paso.

Objectives: Refeeding syndrome is a life-threatening, physiological process that occurs when patients with severe malnutrition are too rapidly rehabilitated, leading to the development of electrolyte abnormalities. Hypophosphatemia, a hallmark of the disease, has most commonly been studied, because it is recognized to result in cardiac arrhythmias, seizures, cardiac failure, respiratory failure, rhabdomyolysis, coma, and even death. Although many studies have found caloric intake to be a main causal factor in refeeding syndrome, few have explored other factors, such as geographic location. Read More

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A tale of two extremities: A dynamic case of Covid-19 induced hypokalemia and bradycardia leading into Torsade's de pointes.

Ann Med Surg (Lond) 2021 Jun 27;66:102416. Epub 2021 May 27.

William Harvey Hospital, UK.

Introduction: As researchers and academics around the world scramble ahead to dissect and analyse every aspect of the SARS-CoV2 virus, one such study explored the various underlying electrolyte abnormalities that were precipitated in patients suffering from a confirmed COVID-19 infection. A significant proportion of such patients were noted to be hypokalemic. Hypokalemia can be life threatening as it is known to cause cardiac arrhythmia. Read More

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Potassium Metabolism and Management in Patients with CKD.

Nutrients 2021 May 21;13(6). Epub 2021 May 21.

Kidney Center, Ohno Memorial Hospital, 1-26-10, Minami-Horie, Nishi-ku, Osaka 550-0015, Japan.

Potassium (K), the main cation inside cells, plays roles in maintaining cellular osmolarity and acid-base equilibrium, as well as nerve stimulation transmission, and regulation of cardiac and muscle functions. It has also recently been shown that K has an antihypertensive effect by promoting sodium excretion, while it is also attracting attention as an important component that can suppress hypertension associated with excessive sodium intake. Since most ingested K is excreted through the kidneys, decreased renal function is a major factor in increased serum levels, and target values for its intake according to the degree of renal dysfunction have been established. Read More

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Estimation of Potassium Changes Following Potassium Supplements in Hypokalemic Critically Ill Adult Patients-A Patient Personalized Practical Treatment Formula.

J Clin Med 2021 May 5;10(9). Epub 2021 May 5.

General Intensive Care Unit, Soroka University Medical Center, Beer-Sheva 8410101, Israel.

Hypokalemia is common among critically ill patients. Parenteral correction of hyperkalemia depends on dosages and patient characteristics. Our aims were to assess changes in potassium levels following parenteral administration, and to derive a formula for predicting rises in serum potassium based on patient characteristics. Read More

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Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet.

J Chemother 2021 Jun 1:1-8. Epub 2021 Jun 1.

Department of Pharmacy, Kindai University Nara Hospital, Ikoma, Japan.

This study aimed to investigate the relationship between renal dysfunction and electrolyte abnormalities, which are adverse events of foscarnet used for cytomegalovirus infection. Of the Ninety hematopoietic stem cell transplantation patients, 32 who met the selection criteria were enrolled in this retrospective study. The study patients were divided into two groups according to whether they developed renal dysfunction. Read More

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The Effect of Antihypertensive Medications on Testing for Primary Aldosteronism.

Front Pharmacol 2021 13;12:684111. Epub 2021 May 13.

Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.

Primary aldosteronism (PA) is a potentially curable form of secondary hypertension caused by excessive renin-independent aldosterone secretion, leading to increased target organ damage and cardiovascular morbidity and mortality. The diagnosis of PA requires measuring renin and aldosterone to calculate the aldosterone-to-renin ratio, followed by confirmatory tests to demonstrate renin-independent aldosterone secretion and/or PA subtype differentiation. Various antihypertensive drug classes interfere with the renin-angiotensin-aldosterone axis and hence evaluation for PA should ideally be performed off-drugs. Read More

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[Development and validation of a clinical predictive model for the risk of malignant ventricular arrhythmia during hospitalization in patients with acute myocardial infarction].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Apr;33(4):438-442

Department of Cardiology, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu, China.

Objective: To develop and validate a clinical prediction model for the risk of malignant ventricular arrhythmia in patients with acute myocardial infarction (AMI) during hospitalization, and evaluate the effect of the prediction model.

Methods: A retrospective study was conducted. A total of 2 649 patients with AMI admitted to cardiology department of Changzhou No. Read More

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Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants With, or at Risk of Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial.

J Pediatr 2021 May 27. Epub 2021 May 27.

Rady Children's Hospital and University of California San Diego, San Diego, CA.

Objective: To investigate the efficacy and safety of sildenafil added to inhaled nitric oxide (iNO) for newborn infants with persistent pulmonary hypertension of newborn (PPHN) or hypoxic respiratory failure (HRF) at risk of PPHN.

Study Design: Part A of a multinational, randomized, double-blind, placebo-controlled trial. Infants ≤96hrs-old, >34 weeks of gestation, receiving iNO (10-20ppm on ≥50% FiO) for PPHN or HRF at risk of PPHN, and oxygen index >15-<60, were randomized (1:1) to IV sildenafil (loading: 0. Read More

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Safety and efficacy of abiraterone acetate plus prednisolone in patients with castration-resistant prostate cancer: a prospective, observational, post-marketing surveillance study.

Jpn J Clin Oncol 2021 May 29. Epub 2021 May 29.

Japan Safety and Surveillance, Janssen Pharmaceutical K.K., Tokyo, Japan.

Background: Abiraterone acetate plus prednisolone is approved to treat patients with castration-resistant prostate cancer. This study evaluated the safety and efficacy of abiraterone acetate plus prednisolone in castration-resistant prostate cancer patients with or without previous chemotherapy in a real-world setting in Japan.

Methods: This study was an observational, prospective, post-marketing surveillance. Read More

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Effect of Different Garlic Preparations on Testosterone, Thyroid Hormones, and Some Serum Trace Elements in Rats.

Biol Trace Elem Res 2021 May 29. Epub 2021 May 29.

Radioisotopes Department, Egyptian Atomic Energy Authority, Giza, Egypt.

Garlic is a house-available vegetable which is widely used for its spicy and medicinal benefits. Impact of different preparations on testosterone, thyroid hormones, and blood micro and trace elements were studied. Eight groups of male albino rats were selected including control group and other seven groups administered different doses of different garlic preparations by oral gavages for 1 month. Read More

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The proarrhythmic effects of hypothermia in atria isolated from 5-HT-receptor-overexpressing mice.

Eur J Pharmacol 2021 May 25;906:174206. Epub 2021 May 25.

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany. Electronic address:

We investigated whether hypothermia would be arrhythmogenic in mice that overexpress the human 5-HT receptor only in their cardiac myocytes (5-HT-TG). Contractile studies were performed in isolated, electrically driven (1 Hz) left and spontaneously beating right atrial preparations of 5-HT-TG and littermate wild-type control mice (WT). Hypothermia (23 °C) decreased the force of contraction in the mouse right and left atrial preparations. Read More

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