13,752 results match your criteria Hypokalemia


Assessment of the risk of QT-interval prolongation associated with potential drug-drug interactions in patients admitted to Intensive Care Units.

Saudi Pharm J 2019 Feb 10;27(2):229-234. Epub 2018 Nov 10.

Department of Pharmacy, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Objectives: To evaluate the relationship between drug interactions and QT-interval prolongation in patients admitted to a general intensive care unit (ICU).

Methods: This study was approved by the Institutional Review Board and written informed consent was obtained from all patients. From May 2015 to July 2016, all patients over 18 years-old admitted to the ICU for more than 24 h and in whom the QT-interval on the ECG could be read were prospectively included in this observational, cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362170PMC
February 2019

Inadequate Dietary Potassium and Progression of CKD.

Authors:
Thomas D DuBose

Clin J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; and

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http://dx.doi.org/10.2215/CJN.01020119DOI Listing
February 2019

[A child with severe growth delay and renal cysts].

G Ital Nefrol 2019 Feb;36(1)

UO Genetica Medica, Ospedale Meyer Firenze.

We describe the case of a 5-year-old who came to our attention for a growth delay. Among the investigations planned because of the child's short stature, we performed an abdominal ultrasound showing normal-sized kidneys with signs of cortico-medullar de-differentiation, diffuse medullary hyperechogenicity with reduction of cortical thickness and cortical-medullary cysts. The ultrasound findings, also confirmed in MRI, led us to suspect a genetically determined cystic nephropathy of the nephronophthisis or medullary cystic disease type. Read More

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February 2019

Gitelman syndrome presenting with cerebellar ataxia: a case report.

Acta Neurol Belg 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, School of Medicine, Izmir, Turkey.

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http://dx.doi.org/10.1007/s13760-019-01095-6DOI Listing
February 2019

Electrolyte Disorders as Triggers for Takotsubo Cardiomyopathy.

Eur J Case Rep Intern Med 2018 24;5(4):000760. Epub 2018 Apr 24.

Internal Medicine Department, Brugmann University Hospital, Brussels, Belgium.

A 56-year-old woman presented with cognitive impairment, confusion and slowed speech, muscle cramps and peripheral paraesthesia preceded by vomiting. Blood tests revealed severe hypokalaemia, hyponatremia, hypomagnesemia and hypocalcaemia. Following a diagnosis of Takotsubo cardiomyopathy based on ultrasonography, the patient was treated with electrolyte supplementation and recovered within 48h. Read More

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http://dx.doi.org/10.12890/2018_000760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346755PMC

Osteomalacia in a Case of Adult-Onset Bartter Syndrome.

Eur J Case Rep Intern Med 2018 21;5(3):000764. Epub 2018 Mar 21.

Internal Medicine, Liaquat College of Medicine and Dentistry and Darul Sehat Hospital, Karachi, Pakistan.

Bartter syndrome is a rare heterogeneous disease characterised by a deficiency in sodium and chloride absorption. Gain-of-function mutations in the CASR gene have been described in some patients with Bartter syndrome associated with hypocalcaemia and hypercalciuria. We describe a case of adult-onset Bartter syndrome with hypocalcaemia severe enough to cause osteomalacia. Read More

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http://dx.doi.org/10.12890/2018_000764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346954PMC

Perioperative management of patient with Conn's syndrome and severe hypokalaemia: How low is too low?

Indian J Anaesth 2019 Jan;63(1):67-68

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.4103/ija.IJA_562_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341878PMC
January 2019
1 Read

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
2 Reads

Hypokalaemia induced by thymic neuroendocrine tumour mimicking major depressive disorder in a geriatric patient.

Psychogeriatrics 2019 Feb 10. Epub 2019 Feb 10.

Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1111/psyg.12428DOI Listing
February 2019
1 Read

Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial.

J Bone Oncol 2019 Apr 23;15:100217. Epub 2019 Jan 23.

Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No 44 of Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province 110042, China.

Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven.

Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with surgically unsalvageable giant cell tumor of bone.

Methods: A total of 250 patients with surgically unsalvageable giant cell tumor of bone were included in this randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357891PMC
April 2019
1 Read

poisoning: a case report of intentional poisoning.

BMJ Case Rep 2019 Feb 9;12(2). Epub 2019 Feb 9.

Neurology, Vinayaka Neuro Multispecialty Clinic, Warangal, India.

We report a case of 50-year-old male patient from tribal area in South Indian state of Telangana, who ingested the liquid extract from crushed leaves of the plant, cleistanthus collinius with the intention of self-harm. Immediate gastric lavage and activated charcoal administration was done and the patient was subsequently admitted into an acute medical care unit. During first 24 hours of monitoring, the patient was clinically stable. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22819
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http://dx.doi.org/10.1136/bcr-2018-228197DOI Listing
February 2019
5 Reads

[Atypical presentation of rhabdomyolysis due to hypokalaemia induced by diuretics abuse: Case report from Sierra Leone.]

Rev Fac Cien Med Univ Nac Cordoba 2018 11 13;75(4):310-313. Epub 2018 Nov 13.

Médecins Sans Frontières.

Rhabdomyolysis results from acute necrosis of skeletal muscle fibres and consequent leakage of muscle constituents into the circulation. Its association with anything different than trauma in the Emergency Room is not that frequent. We present the case of a 47-year-old male, hypertensive, that developed weakness and incapability to walk without help, finding on the blood biochemistry that he had developed a rhabdomyolysis due to hipokalemia after abusing of diuretics. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n4.20398DOI Listing
November 2018
1 Read

Influence of potassium levels on one-year outcomes in elderly patients with acute heart failure.

Eur J Intern Med 2019 02 26;60:24-30. Epub 2018 Oct 26.

Internal Medicine Department, IMIBIC/Hospital Reina Sofía, Universidad de Córdoba, Córdoba, Spain.

Background: Abnormal serum potassium levels (K) in patients with heart failure (HF) relate to worse prognosis. We evaluated whether admission K levels predict 1-year outcomes in elderly patients admitted for acute HF.

Methods: We evaluated 2865 patients aged >74 years from the RICA Spanish Heart Failure Registry, classified according to admission serum K levels: hyperkalemia (>5. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.10.016DOI Listing
February 2019
2 Reads

A Case of Primary Aldosteronism Due to A Primary Adrenal Adenoma Diagnosed by Segmental Adrenal Venous Sampling (S-AVS) Using a Modified Catheter System and Lateral Cine Angiography.

Am J Case Rep 2019 Feb 2;20:139-145. Epub 2019 Feb 2.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.

BACKGROUND Before partial adrenalectomy for primary aldosteronism due to a primary adrenal adenoma, the aldosterone-producing tumor can be localized by segmental adrenal vein sampling (S-AVS). Cardiologists, who regularly perform percutaneous coronary intervention (PCI), or coronary angioplasty with stent, may not be familiar with the technique of S-AVS. A case of the use of S-AVS is reported in a patient who presented with primary aldosteronism and a right adrenal adenoma. Read More

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http://dx.doi.org/10.12659/AJCR.913172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368131PMC
February 2019
1 Read

Effectiveness and Safety of Potassium Replacement in Critically Ill Patients: A Retrospective Cohort Study.

Crit Care Nurse 2019 Feb;39(1):e13-e18

Drayton A. Hammond is a clinical pharmacy specialist, medical and cardiac intensive care, Department of Pharmacy, Rush University Medical Center, Chicago, Illinois.

Background: Rules of thumb for potassium replacement are used in intensive care units despite minimal empirical validation.

Objective: To evaluate the effectiveness and safety of rule-of-thumb potassium replacement in critically ill patients with mild and moderate hypokalemia.

Methods: A retrospective, observational study was done of patients with mild (potassium, 3-3. Read More

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http://dx.doi.org/10.4037/ccn2019705DOI Listing
February 2019
1 Read

Is Milrinone Effective for Infants with Mild-to-Moderate Congenital Diaphragmatic Hernia?

Am J Perinatol 2019 Feb 1. Epub 2019 Feb 1.

Division of Neonatology, Primary Children's Hospital, Salt Lake City, Utah.

Background:  Pulmonary hypertension with left ventricular dysfunction commonly occurs in congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-III inhibitor with lusitropic and vasodilator effects, is used in up to 30% of CDH infants across the United States. No randomized trials have tested the efficacy or safety of milrinone in CDH neonates. Read More

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http://dx.doi.org/10.1055/s-0039-1678558DOI Listing
February 2019
2 Reads

Phase 1 study of lenalidomide plus dose-adjusted EPOCH-R in patients with aggressive B-cell lymphomas with deregulated MYC and BCL2.

Cancer 2019 Feb 1. Epub 2019 Feb 1.

Division of Hematology/Oncology, University of Chicago, Chicago, Illinois.

Background: Dual translocation of MYC and BCL2 or the dual overexpression of these proteins in patients with aggressive B-cell lymphomas (termed double-hit lymphoma [DHL] and double-expressor lymphoma [DEL], respectively) have poor outcomes after chemoimmunotherapy with the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Retrospective reports have suggested improved outcomes with dose-intensified regimens. In the current study, the authors conducted a phase 1 study to evaluate the feasibility, toxicity, and preliminary efficacy of adding lenalidomide to dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin with rituximab (DA-EPOCH-R) in patients with DHL and DEL. Read More

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http://dx.doi.org/10.1002/cncr.31877DOI Listing
February 2019
1 Read

Surprisingly low aldosterone levels in peripheral veins following intravenous sedation during adrenal vein sampling: implications for the concept of nonsuppressibility in primary aldosteronism.

J Hypertens 2019 Mar;37(3):596-602

Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC.

Background: Constituitively high and nonsuppressible aldosterone levels are considered to be the hallmark of primary aldosteronism. We observed a high proportion of primary aldosteronism patients with surprisingly low aldosterone levels in peripheral veins during adrenal vein sampling (AVS) and sought to further characterize the phenomenon.

Methods: Database analysis of patients with primary aldosteronism at the University of Calgary who underwent AVS under intravenous sedation. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001905DOI Listing
March 2019
2 Reads

Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus.

Endocr J 2019 Jan 29. Epub 2019 Jan 29.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Although hyperemesis gravidarum (HG), an extreme form of morning sickness, is a common complication during pregnancy, HG associated simultaneous onset of rhabdomyolysis and diabetes insipidus due to electrolyte abnormalities are rare. A 34-year-old woman with severe HG at 17 weeks of gestation complicated with appetite loss, weight reduction by 17 kg, general fatigue, myalgia, weakness and polyuria was identified to have simultaneous hypophosphatemia (1.6 mg/dL) and hypokalemia (2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0496DOI Listing
January 2019
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Development and validation of a dynamic inpatient risk prediction model for clinically significant hypokalemia using electronic health record data.

Am J Health Syst Pharm 2019 Feb;76(5):301-311

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL.

Purpose: The purpose of this study was to develop a dynamic risk prediction model for inpatient hypokalemia and evaluate its predictive performance.

Methods: A retrospective cohort included all admissions aged 18 years and above from 2 large tertiary hospitals in Florida over a 22-month period. Hypokalemia was defined as a potassium value of less than 3 mmol/L, and subsequent initiation of potassium supplements. Read More

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http://dx.doi.org/10.1093/ajhp/zxy051DOI Listing
February 2019
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Amiodarone-induced life-threatening torsade de pointes in an end-stage lung cancer patient receiving gefitinib.

Oxf Med Case Reports 2019 Jan 24;2019(1):omy122. Epub 2019 Jan 24.

Department of Cardiovascular Medicine, First Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, China.

The risk factors of acquired long QT syndrome (aLQTS) are sometimes overlooked in clinics. Drugs, hypokalemia, age and female sex are well-known risk factors of QT prolongation-dependent torsade de pointes (TdP), which explains the high incidence of sudden cardiac death in LQT patients. Here, we report a case of an elderly female patient with lung cancer who was in poor condition, for whom amiodarone was mistakenly prescribed to rectify premature ventricular contractions. Read More

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http://dx.doi.org/10.1093/omcr/omy122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345081PMC
January 2019
1 Read

Effects of diabetic ketoacidosis in the respiratory system.

World J Diabetes 2019 Jan;10(1):16-22

Division of Pulmonary, Critical Care and Sleep Medicine, Texas A and M University, Corpus Christy, TX 78412, United States.

Diabetes affects approximately 30 million persons in the United States. Diabetes ketoacidosis is one of the most serious and acute complications of diabetes. At the time of presentation and during treatment of diabetic ketoacidosis (DKA), several metabolic and electrolyte derangements can ultimately result in respiratory compromise. Read More

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http://dx.doi.org/10.4239/wjd.v10.i1.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347653PMC
January 2019
2 Reads

Two novel heterozygous mutations in the CYP17A1 gene in a Chinese patient with 17α-hydroxylase 17,20-lyase deficiency.

Discov Med 2018 Dec;26(145):243-249

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.

Congenital adrenal hyperplasia (CAH) resulting from 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is an uncommon autosomal recessive disease. 17-OHD is caused by mutations in the cytochrome P450c17 gene (CYP17A1), and characterized by hypertension, hypokalemia, female sexual infantilism, or male pseudohermaphroditism. Here we report a case of a 19-year-old Chinese girl (46,XX) with 17-OHD, and analyze her clinical and molecular genetic characteristics. Read More

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December 2018
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Intractable Hypokalemia: a Red Herring for Rapidly Evolving Ectopic Cushing's Syndrome.

Isr Med Assoc J 2019 Jan;21(1):60-62

Department of Medicine, Hadassah-Hebrew University Medical Center, Ein Kerem Campus, Jerusalem, Israel.

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January 2019
2 Reads
0.903 Impact Factor

[A case of periodic thyrotoxic paralysis].

Authors:
G Kisoka X Bertrand

Rev Med Liege 2019 Jan;74(1):20-22

Département des Urgences, CHR Citadelle, Liège, Belgique.

Periodic thyrotoxic paralysis (TPP) is a disease that usually affects Asian men from 20 to 50 years. It is secondary to genetic mutations of ion channels for the transport of sodium and potassium. It is characterized by recurrent and brutal bouts of paresis / flaccid paralysis, without sensory involvement, in a context of hyperthyroidism. Read More

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January 2019
4 Reads

Functional biological pacemaker generation by T-Box18 protein expression via stem cell and viral delivery approaches in a murine model of complete heart block.

Pharmacol Res 2019 Jan 21;141:443-450. Epub 2019 Jan 21.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Tehran, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Tehran, Iran; School of Medicine, Mashhad University of Medical Sciences, Tehran, Iran.

Despite recent advances in the treatment of cardiac arrhythmia, the available options are still limited and associated with some complications. Induction of biological pacemakers via Tbx18 gene insertion in the heart tissue has been suggested as a promising therapeutic strategy for cardiac arrhythmia. Following a previous in vitro study reporting the production of Tbx18-expressing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), we aimed to investigate the efficacy of these engineered cells to generate pacemaker rhythms in a murine model of complete heart block. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183177
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http://dx.doi.org/10.1016/j.phrs.2019.01.034DOI Listing
January 2019
5 Reads

Chomping at the Bit: A Descriptive Report on Pediatric Clenbuterol Ingestion.

J Pharm Pract 2019 Jan 22:897190018823114. Epub 2019 Jan 22.

2 Department of Emergency Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA.

Introduction:: Clenbuterol hydrochloride is a selective beta-2 adrenergic agonist with uses in both humans and animals. Ingestions occurring within the United States are generally due to incidental ingestion of a veterinary product, use as a cutting agent for illicit substances, or illegal use for performance-enhancing purposes.

Case Report:: A four-and-a-half year-old male presented approximately two-and-a-half hours after an accidental ingestion of an unknown quantity of clenbuterol. Read More

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http://dx.doi.org/10.1177/0897190018823114DOI Listing
January 2019
1 Read

Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders.

Cochrane Database Syst Rev 2019 Jan 21;1:CD010827. Epub 2019 Jan 21.

Translational Health Research Institute, Western Sydney University, Penrith, New South Wales, Australia, 2751.

Background: Clinical guidelines recommend outpatient care for the majority of people with an eating disorder. The optimal use of inpatient treatment or combination of inpatient and partial hospital care is disputed and practice varies widely.

Objectives: To assess the effects of treatment setting (inpatient, partial hospitalisation, or outpatient) on the reduction of symptoms and increase in remission rates in people with:1. Read More

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http://doi.wiley.com/10.1002/14651858.CD010827.pub2
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http://dx.doi.org/10.1002/14651858.CD010827.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353082PMC
January 2019
6 Reads

Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Department of Internal Medicine, Kantonsspital Graubunden, Chur, Switzerland.

Two years after diagnosis of a metastatic neuroendocrine gastrin-secreting tumour and after several cycles of chemotherapy and peptide receptor radionuclide therapy, a 56-year-old woman presented with hypokalaemic metabolic alkalosis, hypertension, leg oedema and new-onset diabetes mellitus. Further investigations revealed renal potassium loss confirmed by a transtubular potassium gradient of 16, fully suppressed serum aldosterone, but instead highly elevated blood levels of morning cortisol and adrenocorticotropic hormone as well as increased urinary excretion of glucocorticoid and mineralocorticoid metabolites. Ruling out other causes, paraneoplastic hypercortisolism was diagnosed. Read More

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http://dx.doi.org/10.1136/bcr-2018-227068DOI Listing
January 2019
2 Reads

[Muscle weakness with hypokalemia and hyperthyroidism in an adolescent with Down syndrome].

Arch Argent Pediatr 2019 02;117(1):e37-e40

Servicio de Endocrinología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Acute hypokalemic paralysis is a rare cause of acute weakness. Thyrotoxic periodic paralysis (TPP) is an unusual complication of hyperthyroidism. It is characterized by sudden onset of hypokalemia condition resulting from a shift of potassium into cells and paralysis that primarily affects the lower extremities. Read More

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http://dx.doi.org/10.5546/aap.2019.e37DOI Listing
February 2019
1 Read

Renal physiology and fluid and electrolyte disorders in pregnancy.

Best Pract Res Clin Obstet Gynaecol 2018 Dec 4. Epub 2018 Dec 4.

Division of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, Canada. Electronic address:

The majority of women are healthy entering pregnancy and do not require measurement of renal function or serum electrolytes. Clinicians must remain alert to the possibility of renal as well as fluid and electrolyte disorders in pregnancy, as the presenting complaints are often vague and mistaken for the normal physiology of pregnancy. In this chapter, our objectives are 1) to review the renal physiology from a practical/clinical standpoint; 2) to provide the clinical obstetrician a case-based approach to fluid and electrolyte disorders commonly encountered in pregnancy; 3) to consolidate knowledge on renal physiology and fluid and electrolyte disorders in pregnancy with MCQs that are directly aligned with content; and 4) to highlight key practice points and present a research agenda. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.11.008DOI Listing
December 2018
1 Read

One more reason to avoid purgatives before capsule endoscopy examinations: Hypokalemia and low completion rates.

Saudi J Gastroenterol 2019 Jan 14. Epub 2019 Jan 14.

Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.

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http://dx.doi.org/10.4103/sjg.SJG_577_18DOI Listing
January 2019
1 Read

Anti-mitochondria antibody-related tubulointerstitial nephritis accompanied by severe hypokalemic paralysis.

CEN Case Rep 2019 Jan 14. Epub 2019 Jan 14.

Department of Nephrology, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Sakai City, Osaka, 591-8025, Japan.

A 47-year-old man presented with severe hypokalemic paralysis and respiratory failure. A large amount of potassium was administered along with providing intensive care, and his condition improved. Hypokalemia was attributed to increased urinary potassium excretion. Read More

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http://dx.doi.org/10.1007/s13730-019-00376-6DOI Listing
January 2019
1 Read

Phase II Trial of MEK Inhibitor Binimetinib (MEK162) in RAS-mutant Acute Myeloid Leukemia.

Clin Lymphoma Myeloma Leuk 2018 Dec 20. Epub 2018 Dec 20.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Background: Relapsed and refractory (R/R) acute myeloid leukemia (AML) continues to be a therapeutic challenge with poor outcomes. Dysregulation of the mitogen-activated protein (MAP) kinase/extracellular-signal regulated kinase (ERK) pathway frequently occurs in AML and myelodysplastic syndrome (MDS). Preclinical studies and early-phase trials have shown promise for MAP-ERK kinase (MEK) inhibition in AML. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21522650183067
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http://dx.doi.org/10.1016/j.clml.2018.12.009DOI Listing
December 2018
6 Reads

Serum potassium and clinical outcomes in heart failure patients: results of risk calculations in 21 334 patients in the UK.

ESC Heart Fail 2019 Jan 10. Epub 2019 Jan 10.

Health Economics and Outcomes Research Ltd, Cardiff, UK.

Aims: At present, the clinical burden of hypokalaemia and hyperkalaemia among European heart failure patients, and relationships between serum potassium and adverse clinical outcomes in this population, is not well characterized. The aim of this study was to investigate associations between mortality, major adverse cardiac events, and renin-angiotensin-aldosterone system inhibitor (RAASi) discontinuation across serum potassium levels, in a UK cohort of incident heart failure patients.

Methods And Results: This was a retrospective observational cohort study of newly diagnosed heart failure patients listed in the Clinical Practice Research Datalink, with a first record of heart failure (index date) between 2006 and 2015. Read More

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http://dx.doi.org/10.1002/ehf2.12402DOI Listing
January 2019
2 Reads

Kir4.1/5.1 in the DCT plays a role in the regulation of renal K excretion.

Am J Physiol Renal Physiol 2019 Jan 9. Epub 2019 Jan 9.

Dept of Pharmacology, New York Medical College, United States.

The aim of this mini review is to provide an overview regarding the role of inwardly-rectifying potassium channel 4.1 (Kir4.1)/Kir5. Read More

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http://dx.doi.org/10.1152/ajprenal.00412.2018DOI Listing
January 2019
2 Reads

A new compound heterozygous mutation in a female with 17α-hydroxylase/17,20-lyase deficiency, slipped capital femoral epiphysis, and adrenal myelolipoma.

Gynecol Endocrinol 2019 Jan 7:1-5. Epub 2019 Jan 7.

a Department of Endocrinology , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.

17α-Hydroxylase/17,20-lyase deficiency (17-OHD) is a rare disease caused by mutations of the CYP17A1 gene. Slipped capital femoral epiphysis (SCFE) rarely occurs in adults. There are occasional reports of adrenal myelolipoma (AML) in 17-OHD. Read More

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http://dx.doi.org/10.1080/09513590.2018.1540576DOI Listing
January 2019
1 Read
1.136 Impact Factor

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition.

Pediatr Rheumatol Online J 2019 Jan 5;17(1). Epub 2019 Jan 5.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Yan-an Road, Hangzhou, 310003, China.

Background: As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop Kawasaki disease shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study was to learn more about the clinical features and evaluate the role of cytokines in the pathogenesis of KDSS. Read More

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http://dx.doi.org/10.1186/s12969-018-0303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321686PMC
January 2019
2 Reads

Efficacy and Safety of Spironolactone in Patients With HFpEF and Chronic Kidney Disease.

JACC Heart Fail 2019 Jan;7(1):25-32

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Objectives: This study investigated the association between baseline renal function and the net benefit of spironolactone in patients with heart failure (HF) with a preserved ejection fraction (HFpEF).

Background: Guidelines recommend consideration of spironolactone to reduce HF hospitalization in HFpEF. However, spironolactone may increase risk for hyperkalemia and worsening renal function, particularly in patients with chronic kidney disease. Read More

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http://dx.doi.org/10.1016/j.jchf.2018.10.017DOI Listing
January 2019
1 Read

Impact of adrenocorticotropic hormone stimulation during adrenal venous sampling on outcomes of primary aldosteronism.

J Hypertens 2018 Dec 28. Epub 2018 Dec 28.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto.

Background: Adrenal venous sampling (AVS) is essential for identifying a surgically curable form of primary aldosteronism. Adrenocorticotropic hormone (ACTH) infusion or bolus has been reported to improve the success rate of AVS, although the effects on lateralization and its outcomes in unilateral primary aldosteronism are unclear.

Methods: The success rate and lateralization indices were examined in a cohort of 2197 Japanese patients with primary aldosteronism from 28 centres who underwent AVS. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001964DOI Listing
December 2018
3 Reads

Brugada phenocopy due to hypokalemia.

J Family Med Prim Care 2018 Sep-Oct;7(5):1141-1142

Division of Cardiology, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.4103/jfmpc.jfmpc_64_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259498PMC
January 2019
1 Read

Clinical and Genetic Characteristics in Patients With Gitelman Syndrome.

Kidney Int Rep 2019 Jan 28;4(1):119-125. Epub 2018 Sep 28.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Introduction: Gitelman syndrome (GS) is a tubulopathy exhibited by salt loss. GS cases are most often diagnosed by chance blood test. Aside from that, some cases are also diagnosed from tetanic symptoms associated with hypokalemia and/or hypomagnesemia or short stature. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308995PMC
January 2019
2 Reads

Discordance Between Imaging and Adrenal Vein Sampling in Primary Aldosteronism Irrespective of Interpretation Criteria.

J Clin Endocrinol Metab 2018 Dec 24. Epub 2018 Dec 24.

Department of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Subtyping of primary aldosteronism (PA) using imaging and adrenal vein sampling (AVS) may yield discordant results, causing confusion in management. Interpretation criteria for AVS lateralization may affect discordance rates.

Methods: We identified consecutive patients with PA who underwent AVS at a quaternary care centre between January 2006 and May 2018. Read More

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http://dx.doi.org/10.1210/jc.2018-02089DOI Listing
December 2018
3 Reads

[Clinical analysis of perioperative electrolyte imbalance in 999 patients undergoing gastrointestinal surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Dec;21(12):1427-1432

Department of Anesthesia, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China,

Objective: To investigate the perioperative electrolyte imbalance in patients undergoing gastrointestinal surgery.

Methods: Retrospective case analysis was used in this study. Patients who underwent gastrointestinal surgery under general anesthesia at the Sixth Affiliated Hospital of Sun Yat-sen University from January to April 2018 were selected through electronic medical records system. Read More

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December 2018
2 Reads

Characterization of the Effect of Prolonged Therapeutic Hypothermia on Serum Magnesium and Potassium Following Neurological Injury.

Ther Hypothermia Temp Manag 2018 Dec 26. Epub 2018 Dec 26.

Department of Pharmacy, Virginia Commonwealth University Health/Medical College of Virginia Hospitals , Richmond, Virginia.

Current American Heart Association/American Stroke Association guidelines for the management of spontaneous intracerebral hemorrhage suggest therapeutic hypothermia (TH) as a salvage therapy in patients with elevated intracranial pressure. Electrolyte disorders may develop at any stage of the cooling process. Such deregulation can place patients at an increased risk for arrhythmias and worsened neurologic outcomes. Read More

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http://dx.doi.org/10.1089/ther.2018.0037DOI Listing
December 2018
4 Reads

Recurrent seizure-triggered Takotsubo associated with hypokalemia and hypomagnesemia.

Authors:
Josef Finsterer

Seizure 2019 Feb 4;65:176. Epub 2018 Dec 4.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vterinary University of Vienna, Postfach 20, 1180, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.12.001DOI Listing
February 2019
3 Reads

Acute Management of Diabetic Ketoacidosis in Adults at 3 Teaching Hospitals in Canada: A Multicentre, Retrospective Cohort Study.

Can J Diabetes 2018 Nov 17. Epub 2018 Nov 17.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: Diabetic ketoacidosis (DKA) is a common acute complication of diabetes mellitus and is associated with significant morbidity and mortality. There is currently a paucity of data concerning the Canadian experience with DKA. We aimed to characterize the acute management and course of DKA at several Canadian hospitals. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.003DOI Listing
November 2018
2 Reads

Amphotericin B deoxycholate for relapse visceral leishmaniasis in Bangladesh: a cross-sectional study.

BMC Res Notes 2018 Dec 22;11(1):918. Epub 2018 Dec 22.

Critical Care Medicine (CCM), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Objective: Based on studies in India (as there was no studies from outside India) amphotericin B deoxycholate has been considered as a backup drug for treatment of visceral leishmaniasis. However, treatment response and adverse effect to anti-leishmanial drugs may vary across different populations and in Bangladesh the effect to amphotericin B deoxycholate for treatment of visceral leishmaniasis is still unknown. Therefore, there is a need to explore cure rate and adverse effects to amphotericin B deoxycholate to justify its use on visceral leishmaniasis patients in Bangladesh. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-4036-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303843PMC
December 2018
9 Reads

Rates of abnormal aldosterone/renin ratio in African-origin compared to European-origin patients: A retrospective study.

Clin Endocrinol (Oxf) 2018 Dec 21. Epub 2018 Dec 21.

Department of Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Tallaght, Dublin, Ireland.

Introduction: The aldosterone/renin ratio is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this.

Methods: Following clinical observation of a high prevalence of abnormal aldosterone/renin ratio (ARR) in patients of African-origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaemia, intraventricular septal thickness (IVS, by echocardiography) and adrenal imaging were recorded when available. Read More

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http://dx.doi.org/10.1111/cen.13920DOI Listing
December 2018
4 Reads

Meta-analysis of the effects of anti-epidermal growth factor receptor on recurrent/metastatic head and neck squamous cell carcinoma.

Medicine (Baltimore) 2018 Dec;97(51):e13717

Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou.

Background: We performed a meta-analysis to compare the efficacy and safety of anti-epidermal growth factor receptor (EGFR) therapy and non-anti-EGFR therapy in recurrent/metastatic (RM) head and neck squamous cell carcinoma (HNSCC).

Methods: The Cochrane library, WanFang Data, PubMed, Medline, VIP, CBM, and EBSCO databases were searched for relevant studies. The objective response rate (ORR, defined as complete response or partial response according to RECTST version 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000013717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320165PMC
December 2018
1 Read