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    Hyperkalemia is Associated with Increased 30-Day Mortality in Hip Fracture Patients.
    Calcif Tissue Int 2017 Feb 17. Epub 2017 Feb 17.
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark.
    Abnormal plasma concentrations of potassium in the form of hyper- and hypokalemia are frequent among hospitalized patients and have been linked to poor outcomes. In this study, we examined the prevalence of hypo- and hyperkalemia in patients admitted with a fractured hip as well as the association with 30-day mortality in these patients. A total of 7293 hip fracture patients (aged 60 years or above) with admission plasma potassium measurements were included. Read More

    Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes.
    Diabetes Care 2017 Feb 17. Epub 2017 Feb 17.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, U.K.
    Objective: Hypoglycemia may exert proarrhythmogenic effects on the heart via sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac dysrhythmias are linked to the "dead-in-bed syndrome," a rare, but devastating, condition. We examined the effect of nocturnal and daytime clinical hypoglycemia on electrocardiogram (ECG) in young people with type 1 diabetes. Read More

    Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion.
    Am J Med 2017 Feb 14. Epub 2017 Feb 14.
    Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan. Electronic address:
    Background: Uncovering the correct diagnosis of chronic hypokalemia with potassium (K(+)) wasting from the kidneys or gut can be fraught with challenges. We identified clinical and laboratory parameters helpful for differentiating the causes of chronic hypokalemia.

    Methods: Normotensive patients referred to our tertiary academic medical center for the evaluation of chronic hypokalemia were prospectively enrolled over five years. Read More

    Perioperative Concerns for Profound Metabolic Alkalosis During Kidney Transplantation: A Case Report.
    Iran Red Crescent Med J 2016 Nov 2;18(11):e38728. Epub 2016 Oct 2.
    Department of Anesthesiology and Pain Medicine, Gachon University, Gil Medical Center, Incheon, South Korea.
    Introduction: Profound metabolic alkalosis is an uncommon consideration for the anesthetic management of kidney transplantation. Serum total carbon dioxide content and complex electrolyte abnormalities might be important diagnostic clues for the presence of metabolic alkalosis in the absence of arterial blood gas analysis.

    Case Presentation: A 34-year-old female visited Gachon University Gil Medical Center, Incheon, South Korea during year 2015. Read More

    Liquorice: a root cause of secondary hypertension.
    JRSM Open 2017 Feb 1;8(2):2054270416685208. Epub 2017 Jan 1.
    Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.
    We describe a patient presenting with hypertension and hypokalaemia who was ultimately diagnosed with liquorice- induced pseudohyperaldosteronism. This rare cause of secondary hypertension illustrates the importance of a methodical approach to the assessment of hypertension. Read More

    Study of factors affecting the progression and termination of drug induced Torsade de pointes in two dimensional cardiac tissue.
    J Electrocardiol 2017 Feb 2. Epub 2017 Feb 2.
    Biomedical Engineering Group, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, India. Electronic address:
    Introduction: To study the conditions leading to the initiation and termination of drug induced Torsade de pointes (TdP) along with QT prolongation.

    Methods: A 2D anisotropic transmural section of the ventricular myocardium is modeled using the TP06 equations and the cells are interconnected with gap junction conductances (GJC). The tissue is remodeled by reducing the repolarization reserve (by increasing calcium current (ICaL)) of all cells thus making them vulnerable to development of early after depolarizations (EADs). Read More

    Noninvasive quantification of blood potassium concentration from ECG in hemodialysis patients.
    Sci Rep 2017 Feb 15;7:42492. Epub 2017 Feb 15.
    Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
    Blood potassium concentration ([K(+)]) influences the electrocardiogram (ECG), particularly T-wave morphology. We developed a new method to quantify [K(+)] from T-wave analysis and tested its clinical applicability on data from dialysis patients, in whom [K(+)] varies significantly during the therapy. To elucidate the mechanism linking [K(+)] and T-wave, we also analysed data from long QT syndrome type 2 (LQT2) patients, testing the hypothesis that our method would have underestimated [K(+)] in these patients. Read More

    Experiences with Continuous Venovenous Hemofiltration using 18mmol/L predilution Citrate anticoagulation and a Phosphate Containing Replacement Solution.
    Indian J Crit Care Med 2017 Jan;21(1):11-16
    Department of Intensive Care, Intensive Care Unit, Queen Elizabeth Hospital, Kowloon, Hong Kong.
    Context: Regional citrate anticoagulation for continuous renal replacement therapy is associated with a longer filter-life, less bleeding events and improved mortality. Problems associated with using Prismocitrate 10/2 solution in continuous renal replacement therapy, include hypomagnesemia, hypophosphatemia and the need for additional bicarbonate infusion.

    Aims: This study uses the new Prismocitrate 18/0 solution for improved buffer balance and Phoxilium solution for a more favourable electrolyte profile. Read More

    Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy.
    Korean J Intern Med 2017 Feb 15. Epub 2017 Feb 15.
    Department of Pathology, Konyang University Hospital, Daejeon, Korea.
    Background/aims: This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN).

    Methods: After an adaptation period (1 week), a total of 40 C57BL/6 mice (male, 8 weeks old) were divided into four groups: I (control group), II (low potassium [K] diet), III (normal K diet with administration of AA-I [10 mg/kg weight]), and IV (low K diet with AA-I). After collecting 24 hours of urine at 2 weeks, the mice were sacrificed, and their blood and kidneys were obtained to perform immunochemical staining and/or Western blot analysis. Read More

    Prevalence of hypokalemia before and after bowel preparation for colonoscopy in high-risk patients.
    Gastrointest Endosc 2017 Feb 7. Epub 2017 Feb 7.
    Department of Internal Medicine and Gastroenterology, Zuyderland Medical Center, Heerlen, the Netherlands.
    Background And Aims: Bowel preparation for colonoscopy should not cause significant shifts in systemic electrolyte concentrations. We recently encountered 2 cases of severe postcolonoscopy hypokalemia with fatal consequences, prompting us to conduct a study to explore the magnitude of and risk factors for hypokalemia associated with bowel preparation. We paid specific attention to higher risk subgroups, in particular diuretic users, hospitalized patients and patients estimated at to be high risk by the gastroenterologist. Read More

    Clinical and molecular aspects of distal renal tubular acidosis in children.
    Pediatr Nephrol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
    Background: Distal renal tubular acidosis (dRTA) is characterized by hyperchloraemic metabolic acidosis, hypokalaemia, hypercalciuria and nephrocalcinosis. It is due to reduced urinary acidification by the α-intercalated cells in the collecting duct and can be caused by mutations in genes that encode subunits of the vacuolar H(+)-ATPase (ATP6V1B1, ATP6V0A4) or the anion exchanger 1 (SLC4A1). Treatment with alkali is the mainstay of therapy. Read More

    Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
    BMJ Case Rep 2017 Feb 10;2017. Epub 2017 Feb 10.
    Ross University School of Medicine, North Brunswick, New Jersey, USA.
    This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin. Villous adenomas are benign neoplasms with a high incidence of becoming malignant. A small percentage of villous adenomas are known to cause depletion syndrome, also referred to as the McKittrick-Wheelock syndrome, a condition characterised by secretory diarrhoea, dehydration, hyponatremia, hypokalaemia, hypochloraemia, metabolic acidosis and acute renal failure. Read More

    Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case-Control Study.
    J Palliat Med 2017 Feb 10. Epub 2017 Feb 10.
    1 Department of Pharmacy Practice, Wegmans School of Pharmacy, St. John Fisher College , Rochester, New York.
    Background: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs). A unique ME AE is its corrected QT (QTc) interval prolongation risk, but most evidence exists in methadone maintenance therapy patients.

    Objective: Our goal was to identify QTc interval prolongation risk factors in PPC patients receiving ME and other medications known to prolong the QTc interval and develop a risk stratification tool. Read More

    Prognostic factors in ectopic Cushing's syndrome due to neuroendocrine tumors: a multicenter study.
    Eur J Endocrinol 2017 Apr;176(4):451-459
    Section of EndocrinologyDepartment of Medicine, University of Verona, Verona, Italy.
    Objective: Evidence is limited regarding outcome of patients with ectopic Cushing's syndrome (ECS) due to neuroendocrine tumors (NETs).

    Design: We assessed the prognostic factors affecting the survival of patients with NETs and ECS.

    Methods: Retrospective analysis of clinicopathological features, severity of hormonal syndrome, treatments from a large cohort of patients with NETs and ECS collected from 17 Italian centers. Read More

    Correction Equation for Estimation of Actual Potassium Concentration in Hemolyzed Specimen.
    Clin Lab 2017 Feb;63(2):271-275
    Background: A spuriously elevated serum potassium value could possibly cause medical decision errors because it leads to masked hypokalemia or pseudohyperkalemia. The aim of this study was to develop a correction equation for falsely elevated potassium level caused by hemolysis.

    Methods: A total of 988 samples with a hemolysis index (HI) value greater than the potassium alert HI value were recollected within two hours from initial collection. Read More

    Hyponatremia - A rare complication of Gitelman's syndrome.
    Indian J Nephrol 2017 Jan-Feb;27(1):74-77
    Division of Nephrology, Georgetown University/Washington Hospital Center, Washington, DC 20010, USA.
    Gitelman's syndrome (GS) is a rare autosomal recessive disorder caused by mutations in thiazide-sensitive NaCl cotransporter. We report a 49-year-old, normotensive lady with prolonged hypokalemia since her 20s who was diagnosed with GS at our renal clinic. During follow-up, she was found to have mild, asymptomatic, euvolemic hyponatremia with low serum uric acid, inappropriately high urine osmolality and sodium consistent with syndrome of inappropriate antidiuretic hormone-like presentation. Read More

    Mild Hypokalemia and Supraventricular Ectopy Increases the Risk of Stroke in Community-Dwelling Subjects.
    Stroke 2017 Feb 7. Epub 2017 Feb 7.
    From the Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Denmark.
    Background And Purpose: Stroke is independently associated with the common conditions of hypokalemia and supraventricular ectopy, and we hypothesize that the combination of excessive supraventricular ectopic activity and hypokalemia has a synergistic impact on the prognosis in terms of stroke in the general population.

    Methods: Subjects (55-75 years old) from the Copenhagen Holter Study cohort (N=671) with no history of atrial fibrillation or stroke were studied-including baseline values of potassium and ambulatory 48-hour Holter monitoring. Excessive supraventricular ectopic activity is defined as ≥30 premature atrial complexes per hour or any episodes of runs of ≥20. Read More

    Ileal Neobladder: An Important Cause of Non-Anion Gap Metabolic Acidosis.
    J Emerg Med 2017 Feb 3. Epub 2017 Feb 3.
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts and Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts.
    Background: The differential diagnosis for a non-anion gap metabolic acidosis is probably less well known than the differential diagnosis for an anion gap metabolic acidosis. One etiology of a non-anion gap acidosis is the consequence of ileal neobladder urinary diversion for the treatment of bladder cancer.

    Case Report: We present a case of a patient with an ileal neobladder with a severe non-anion gap metabolic acidosis caused by a urinary tract infection and ureteroenterostomy. Read More

    Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors.
    Invest New Drugs 2017 Feb 4. Epub 2017 Feb 4.
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
    Purpose Macrophage-stimulating 1-receptor (RON) is expressed on macrophages, epithelial cells, and a variety of tumors. Narnatumab (IMC-RON8; LY3012219) is a neutralizing monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP). This study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and efficacy of narnatumab in patients with advanced solid tumors. Read More

    The Use of Complementary and Alternative Medicine Among Dialysis Patients.
    Altern Ther Health Med 2017 Jan;23(1):56-60
    Context • The use of complementary and alternative medicine (CAM) has been on the rise in the last decade. Subpopulations of patients with chronic diseases are at risk for adverse events and potential drug-herb interactions, among them dialysis patients. Objective • The study aimed to evaluate the prevalence of CAM consumption among dialysis patients and to search for potential interactions. Read More

    The diagnosis of bilateral primary renal paragangliomas in a cat.
    J S Afr Vet Assoc 2017 Jan 24;88(0):e1-e6. Epub 2017 Jan 24.
    Fourways Vet Hospital, Johannesburg; Faculty of Veterinary Science, Department of Companion Animal Clinical Studies, University of Pretoria.
    A 9-year-old sterilised female domestic short-hair cat was referred with a history of vomiting and anorexia of 3 months' duration. Biochemistry, full-blood counts, thoracic radiographs, feline pancreatic-specific lipase, abdominal ultrasonography and feline immunodeficiency virus/feline leukaemia virus (FIV/FeLV) SNAP tests had been performed. Mild hypochloraemia and moderate hypokalaemia were evident on initial presentation. Read More

    [Tetraparesis revealing Conn adenoma in a pregnant woman].
    Pan Afr Med J 2016 27;25:24. Epub 2016 Sep 27.
    Service de Médecine Interne, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    We report the case of Conn adenoma revealed by tetraparesis in a 33-year old pregnant woman at the 16(th)week of amenorrhea. The patient had a blood pressure of 147/87 mmHg, which was considered high-normal, hypokalemia at 1.1 mmol/l. Read More

    Near-fatal Anorexia Nervosa in a Middle-aged Woman.
    Intern Med 2017 1;56(3):327-334. Epub 2017 Feb 1.
    Internal Medicine, Galliera Hospital, Italy.
    Anorexia nervosa (AN) is a serious psychiatric disorder which typically occurs in young women; however, more and more cases in middle-aged women are being reported. The management of this complex disease requires a team approach, and full recovery occurs only in 50% of patients. Endocrine and metabolic complications are commonly observed, the latter of which may even be life-threatening, and require prompt and proper management. Read More

    First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors.
    Invest New Drugs 2017 Feb 1. Epub 2017 Feb 1.
    Soricimed Biopharma Inc., Moncton, NB, Canada.
    Introduction This was an open-label, dose escalation (3 + 3 design), Phase I study of SOR-C13 in patients with advanced tumors of epithelial origin. Primary objectives were to assess safety/tolerability and pharmacokinetics. Secondary goals were to assess pharmacodynamics and efficacy of SOR-C13. Read More

    Complications in mechanically ventilated patients of Guillain-Barre syndrome and their prognostic value.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):68-73
    Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
    Introduction: The spectrum of various complications in critically ill Guillain-Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their significance in the prognosis and mortality.

    Materials And Methods: Retrospective case record analysis of all consecutive mechanically ventilated patients of GBS in neurology Intensive Care Unit (ICU) of a tertiary care institute for 10 years was done. Read More

    Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department.
    Clin Med (Lond) 2017 Feb;17(1):43-45
    Plymouth Hospitals NHS Trust, Plymouth, UK.
    A 65-year-old woman with a background of myalgic encephalitis, who was taking alternative medicines and dietary supplements, presented with hypokalaemia and hypertension. After a thorough history it became apparent that this was most likely secondary to regular consumption of liquorice tea. The patient was advised to discontinue drinking this tea and was discharged. Read More

    Hypokalaemia in Sjögren's syndrome: the missing piece.
    Clin Med (Lond) 2017 Feb;17(1):40-42
    National University Health System, Singapore and Yong Loo Lin School of Medicine, National University Singapore, Singapore.
    A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0. Read More

    Syncope: Outcomes and Conditions Associated with Hospitalization.
    Am J Med 2017 Jan 29. Epub 2017 Jan 29.
    University of Iowa Hospitals and Clinics. Iowa City, IA.
    Purpose: Syncope is a perplexing problem for which hospital admission and readmission are contemplated but outcomes remain uncertain. Our purpose was to determine the incidence of admissions and readmissions for syncope and compare associated conditions, in-hospital outcomes and resource utilization.

    Methods: The 2005-2011 California Statewide Inpatient Database was utilized. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    The Mechanism of Valproic Acid-Induced Fanconi Syndrome Involves Mitochondrial Dysfunction and Oxidative Stress in Rat Kidney.
    Nephrology (Carlton) 2017 Jan 31. Epub 2017 Jan 31.
    Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Aim: Drug-induced kidney proximal tubular injury and renal failure (Fanconi syndrome; FS) is a clinical complication. Valproic acid (VPA) is among the FS-inducing drugs. The current investigation was designed to evaluate the role of mitochondrial dysfunction and oxidative stress in VPA-induced renal injury. Read More

    An Unlikely Cause of Hypokalemia.
    J Emerg Med 2017 Jan 28. Epub 2017 Jan 28.
    Temple University Hospital, Philadelphia, Pennsylvania.
    Background: Hypokalemia is a common clinical disorder caused by a variety of different mechanisms. Although the most common causes are diuretic use and gastrointestinal losses, elevated cortisol levels can also cause hypokalemia through its effects on the renin-angiotensin-aldosterone system. Cushing's syndrome refers to this general state of hypercortisolemia, which often manifests with symptoms of generalized weakness, high blood pressure, diabetes mellitus, menstrual disorders, and psychiatric changes. Read More

    Paralysis that easily reverses: a case of thyrotoxic periodic paralysis.
    BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.
    Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA.
    Thyrotoxic periodic paralysis is a potentially life-threatening condition associated with recurrent episodes of muscle weakness and hypokalaemia due to hyperthyroidism. Diagnosis is often delayed or misdiagnosed due to its rarity in the western world and subtle features of hyperthyroidism on initial presentation. Here we present the case of a 25-year-old man who presented to the emergency department (ED) with sudden onset weakness of bilateral upper and lower extremities. Read More

    Efficacy of Eplerenone in the Management of Mineralocorticoid Excess in Men With Metastatic Castration-resistant Prostate Cancer Treated With Abiraterone Without Prednisone.
    Clin Genitourin Cancer 2017 Jan 5. Epub 2017 Jan 5.
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:
    Background: Abiraterone acetate has been approved for metastatic castration-resistant prostate cancer (mCRPC). Coadministration with prednisone has been recommended to prevent the toxicity from secondary mineralocorticoid excess, such as hypertension, hypokalemia, and edema. However, the use of prednisone is often not desired by patients because of the potential for detrimental effects of long-term therapy with corticosteroids, especially in those with comorbidities such as diabetes or who have received previous immunotherapeutic agents. Read More

    Down-regulation of Kir2.6 channel by c-termini mutation D252N and its association with the susceptibility to Thyrotoxic Periodic Paralysis.
    Neuroscience 2017 Jan 25;346:197-202. Epub 2017 Jan 25.
    Laboratório de Neurobiologia Estrutural e Funcional, Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address:
    Inward rectifying potassium - Kir - channels drive the resting potential to potassium reversal potential and, when disrupted, might be related to muscular diseases. Recently, Thyrotoxic Periodic Paralysis (TPP) has emerged as a channelopathy related to mutations in KCNJ18 gene, which encodes Kir2.6 channel. Read More

    Effectiveness of patiromer in the treatment of hyperkalemia in chronic kidney disease patients with hypertension on diuretics.
    J Hypertens 2017 Feb 15. Epub 2017 Feb 15.
    aDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland bRelypsa, Inc., Redwood City, California cDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York dDivision of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Objective: Recurrent hyperkalemia frequently limits use of renin-angiotensin-aldosterone system inhibitors (RAASi) in chronic kidney disease (CKD) patients with hypertension, diabetes, and/or heart failure. Patiromer is a sodium-free, nonabsorbed potassium (K)-binding polymer approved by the US Food and Drug Administration for the treatment of hyperkalemia. This post-hoc analysis of OPAL-HK examined the effectiveness and safety of patiromer in reducing serum K in hyperkalemic CKD patients on RAASi, with hypertension, receiving diuretic therapy versus those not on diuretics. Read More

    Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism.
    J Hypertens 2017 Jan 27. Epub 2017 Jan 27.
    aDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka bDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya cDepartment of Internal Medicine, Kansai Rosai Hospital, Amagasaki, Hyogo dDepartment of Internal Medicine of Endocrinology and Metabolism, NTT West Osaka Hospital, Osaka eDepartment of Internal Medicine of Endocrinology and Metabolism, National Hospital Organization, Osaka Minami Medical Center, Kawachinagano fSenrichuo Ekimae Clinic, Toyonaka gNakao Naika Clinic, Osaka hOffice of Biostatistics and Data Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
    Background: Previous studies showed higher risk of cardiovascular and cerebrovascular (CCV) events in primary aldosteronism compared with essential hypertension, but the patients of these studies were limited to primary aldosteronism patients with high plasma aldosterone concentration (PAC). The introduction of the aldosterone-renin ratio as the screening test for primary aldosteronism led to the recognition of primary aldosteronism patients with normal PAC (nPA). However, there is no information on the risk of primary aldosteronism including nPA. Read More

    Successful Management of Refractory Type 1 Renal Tubular Acidosis with Amiloride.
    Case Rep Nephrol 2017 3;2017:8596169. Epub 2017 Jan 3.
    Department of Medicine, Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Nephrology Center of Maryland, Baltimore, MD, USA.
    A 28-year-old female with history of hypothyroidism, Sjögren's Syndrome, and Systemic Lupus Erythematosus (SLE) presented with complaints of severe generalized weakness, muscle pain, nausea, vomiting, and anorexia. Physical examination was unremarkable. Laboratory test showed hypokalemia at 1. Read More

    Bilateral Aldosterone-Producing Adrenocortical Carcinoma: a Rare Entity.
    Indian J Surg Oncol 2017 Mar 18;8(1):88-90. Epub 2016 Oct 18.
    Minimal Invasive Urology, Department of Urology and Kidney Transplant, Medanta, The Medicity, Gurgaon, Haryana 122001 India.
    Adrenal cortical carcinomas (ACC) are rare aggressive malignant neoplasms with a reported incidence of 1-2 cases per 1 million population and account for 0.05-0.2 % of all malignancies. Read More

    Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings.
    BMC Nephrol 2017 Jan 26;18(1):38. Epub 2017 Jan 26.
    Division of Nephrology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
    Background: Gitelman syndrome (GS) is an autosomal recessive renal tubular disorder characterised by renal salt wasting with hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. It is caused by mutations in SLC12A3 encoding the sodium-chloride cotransporter on the apical membrane of the distal convoluted tubule. We report a South African family with five affected individuals presenting with hypokalaemia and unusual food cravings. Read More

    [Gitelman´s syndrome as common cause of hypokalemia and hypomagnesemia].
    Vnitr Lek 2016 ;62(Supplementum 6):78-83
    The Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis and presence of hypocalciuria and hypomagnesemia. It is one of the most common congenital "salt-wasting" tubulo-pathies, where the impairment of function of the Na+-Cl- cotransporter (NCCT) in the distal convoluted tubule is primary and hypokalemia secondary. Hypomagnesemia is caused by the impairment of magnesium reabsorption through TRPM6 channel which is located just by NCCT. Read More

    Effects of low-dose tolvaptan on electrolyte abnormality and hemodynamic parameters in a liver cirrhosis-associated portopulmonary hypertension patient: A case report.
    Exp Ther Med 2017 Jan 1;13(1):269-272. Epub 2016 Dec 1.
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
    The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, under the combination therapy of sildenafil, ambrisentan, furosemide and spironolactone. Subsequent to the initiation of low-dose tolvaptan at 3. Read More

    An Unusual Case of Acute Muscle Weakness.
    Acute Med 2016 ;15(4):209-211
    MRCP(Acute), Consultant Acute Physician, London Northwest Healthcare NHS Trust, Northwick Park Hospital, Watford Road, Harrow.
    A previously healthy 35-year old man presented to hospital with acute leg weakness following an alcohol binge. On assessment, tachycardia, urinary retention and bilateral upper and lower limb proximal weakness with preserved peripheral power were noted. Biochemistry revealed marked hypokalaemia, which responded to intravenous replacement, and biochemical thyrotoxicosis, leading to the diagnosis of Thyrotoxic Periodic Paralysis (TPP). Read More

    Aminoaciduria Caused by Fanconi Syndrome in a Heifer.
    J Vet Intern Med 2017 Jan 21. Epub 2017 Jan 21.
    Laboratoire d'Immuno-Endocrinologie Cellulaire et Moléculaire, INRA, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
    A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18-month-old Holstein heifer. The clinical, biochemical, and histopathological features are described. The heifer had clinical signs of growth retardation, wasting, and persistent diarrhea. Read More

    Efficacy and Safety of Everolimus for Maintenance Immunosuppression of Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials.
    PLoS One 2017 20;12(1):e0170246. Epub 2017 Jan 20.
    Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
    Background: Conversion to everolimus is often used in kidney transplantation to overcome calcineurin inhibitor (CNI) nephrotoxicity but there is conflicting evidence for this approach.

    Objectives: To investigate the benefits and harm from randomized clinical trials (RCTs) involving the conversion from CNI to everolimus after kidney transplantation.

    Methods: Databases were searched up to March 2016. Read More

    Successful Treatment of Suspected Pulmonary Arterial Hypertension in a Mealy Amazon Parrot (Amazona farinose).
    J Avian Med Surg 2016 Dec;30(4):368-373
    A 25-year-old, male mealy Amazon parrot (Amazona farinose) with a history of polycythemia, hepatomegaly, and epistaxis was evaluated for progressive lethargy and anorexia. Clinical laboratory testing revealed severe polycythemia (71%), hypophosphatemia (1.6 mg/dL), and mild hypokalemia (2. Read More

    Ectopic Cushing syndrome in small cell lung cancer: A case report and literature review.
    Thorac Cancer 2016 Nov 8. Epub 2016 Nov 8.
    Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
    Small cell lung cancer (SCLC) is a neuroendocrine tumor with the potential to secrete various peptides or hormones that can lead to paraneoplastic syndromes, such as Ectopic Cushing syndrome (ECS). Because of the aggressive nature of the syndrome and its atypical features, ECS in small-cell lung cancer is difficult to diagnose and has a poor prognosis. We report a case of a 74-year-old male patient who presented with severe hypokalemia, proximal muscle weakness, peripheral edema, metabolic alkalosis, and worsening hyperglycemia. Read More

    Hypokalemic myopathy in primary aldosteronism: A case report.
    Exp Ther Med 2016 Dec 2;12(6):4064-4066. Epub 2016 Nov 2.
    Department of Nephrology, Lishui Hospital Affiliated to Zhejiang University, Lishui, Zhejiang 323000, P.R. China.
    Primary aldosteronism (PA) is a rare disorder. The majority of patients with PA present with typical features and are easily diagnosed. This disorder is usually diagnosed with hypokalemia, hypertension or an adrenal mass. Read More

    Hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies: A single institution Indian experience.
    Natl Med J India 2016 Sep-Oct;29(5):262-266
    Department of Critical Care, Manipal Comprehensive Cancer Center, Manipal Hospital, 98 HAL Airport Road, Bengaluru 560017, Karnataka, India.
    Background: Cytoreductive surgery followed by hyper- thermic intraperitoneal chemotherapy (HIPEC) has shown better oncological outcomes in peritoneal surface malignancies (PSM). We assessed the feasibility and perioperative outcomes of this procedure in Indian patients.

    Methods: In this prospective observational study from February 2013 to April 2015, we included 56 patients (41 females, 73. Read More

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