13,669 results match your criteria Hypokalemia


Bartter syndrome: causes, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 9;11:291-301. Epub 2018 Nov 9.

Nephrology Division, Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, Brazil,

Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Mutations of several genes encoding the transporters and channels involved in salt reabsorption in the thick ascending limb cause different types of Bartter syndrome. A poor phenotype-genotype relationship due to the interaction with other cotransporters and different degrees of compensation through alternative pathways is currently reported. Read More

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November 2018
1 Read

Effects of mineralocorticoid and AT-1 receptor antagonism on the aldosterone-renin ratio (ARR) in primary aldosteronism patients (EMIRA Study): rationale and design.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

Clinica dell'Ipertensione Arteriosa, Department of Medicine - DIMED, University of Padova, Padova, Italy.

Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA). However, abandonment of mineralocorticoid-receptor antagonist (MRA) and/or blockers of the renin-angiotensin system can deteriorate control of blood pressure (BP) and hypokalemia. Thus, in consecutive patients with an unambiguous diagnosis of PA in washout from confounding treatments and subtyped by AVS, we will compare within-patient plasma aldosterone and active renin concentration, and the ARR values, measured at baseline, and after a 1-month treatment with MRA alone and combined with an AT-1 receptor blocker (ARB). Read More

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December 2018

Bumetanide for Autism Spectrum Disorder in Children: A Review of Randomized Controlled Trials.

Ann Pharmacother 2018 Dec 2:1060028018817304. Epub 2018 Dec 2.

1 Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK, USA.

Objective: To evaluate clinical trials using bumetanide in autism spectrum disorder (ASD) treatment.

Data Sources: PubMed and Ovid MEDLINE (1946 to October 2018) were searched using terms bumetanide and autism. Bibliographies were reviewed for other relevant trials. Read More

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December 2018

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.

Cell Rep 2018 Dec;25(10):2668-2675.e3

Division of Nephrology and Hypertension, Oregon Health & Science University, Portland, OR 97239, USA; Fondation LeDucq Transatlantic Networks of Excellence, Paris 75116, France; Renal Section, Veterans Affairs Portland Health Care System, Portland, OR 97239, USA.

Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure. However, constitutive genetic disruptions are likely to have substantial developmental effects in this segment, and whether tubule remodeling upon physiological stimuli is a normal homeostatic mechanism is not known. Since the distal nephron acts as a potassium sensor, we assessed proliferation and tubule length in three dimensions upon dietary or inducible genetic manipulation by using optical clearing of adult mouse kidneys, whole-mount immunolabeling, and advanced light microscopy. Read More

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December 2018
1 Read

Complications somatiques de l’anorexie mentale. Elles sont responsables d’une mortalité élevée.

Rev Prat 2016 Feb;66(2):153-157

Clinique des maladies mentales et de l'encéphale, hôpital Sainte-Anne, Paris, France.

Medical complications of anorexia nervosa. Anorexia nervosa causes acute or chronic medical complications that can affect most organs: dermatologic complications, gastrointestinal complications (including constipation, delayed gastric emptying, rarely hepatitis), endocrine and bone (amenorrhea, infertility, hypoglycemia, delayed puberty, arrested growth, osteoporosis.. Read More

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February 2016
1 Read

Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):862-868

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. Read More

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November 2018

Use of letrozole after aromatase inhibitor-based therapy (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

NRG Oncology/NSABP, Pittsburgh, PA, USA; Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.

Background: The optimal duration of extended therapy with aromatase inhibitors in patients with postmenopausal breast cancer is unknown. In the NSABP B-42 study, we aimed to determine whether extended letrozole treatment improves disease-free survival after 5 years of aromatase inhibitor-based therapy in women with postmenopausal breast cancer.

Methods: This randomised, double-blind, placebo-controlled, phase 3 trial was done in 158 centres in the USA, Canada, and Ireland. Read More

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November 2018

Electrocardiographic manifestations in severe hypokalemia.

J Int Med Res 2018 Dec 4:300060518811058. Epub 2018 Dec 4.

Arrhythmia Unit, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Hypokalemia is one of the most common electrolyte disturbances in the clinic and it can increase the risk of life-threatening arrhythmias. Electrocardiographic characteristics associated with hypokalemia include dynamic changes in T-wave morphology, ST-segment depression, and U waves, which are often best seen in the mid-precordial leads (V2-V4). The PR interval can also be prolonged along with an increase in the amplitude of the P wave. Read More

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December 2018

Primary biliary cirrhosis with refractory hypokalemia: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13172

Department of Hepatology, The First Hospital of Jilin University, Changchun, China.

Rationale: Renal tubular acidosis (RTA) represents a class of metabolic disorders characterized by metabolic acidosis with a normal plasma anion gap. As a rare complication of primary biliary cirrhosis (PBC), RTA is easily overlooked, likely leading to misdiagnosis.

Patient Concerns: A 32-year-old woman who had been diagnosed with PBC at our hospital was found to have hypokalemia due to repeated fatigue for 2 years, and the etiology was unknown. Read More

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November 2018

Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications.

Case Rep Oncol Med 2018 18;2018:4038397. Epub 2018 Oct 18.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USA.

We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival. Read More

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October 2018

Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England.

Authors:
M R Lee

J R Coll Physicians Edinb 2018 Dec;48(4):378-382

112 Polwarth Terrace, Merchiston, Edinburgh EH11 1NN, UK.

Liquorice is a very ancient plant widely used in the East for millennia. It has often been employed in sweets and confectionery and also for minor ailments including cough, constipation and dyspepsia. It was probably carried to Europe by the Cluniac order of monks. Read More

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December 2018
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Comparison of Serum Electrolytes Abnormality and Renal Function Status in Asphyxiated and Normal Baby in a Tertiary Level Hospital.

Mymensingh Med J 2018 Oct;27(4):723-729

Dr Mrinal Kanti Das, Assistant Registrar, Department of Paediatrics, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

Complication of perinatal asphyxia is a major cause of neonatal mortality & morbidity in developing countries. This comparative cross sectional study was conducted in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from May 2012 to September 2012 to determine electrolytes & renal function status in perinatal asphyxia & their impact on outcome. Thirty term normal birth weight babies with perinatal asphyxia in neonatal ward were included as a case group and thirty term normal birth weight neonates of same gestational age, without perinatal asphyxia in the department of Gynae & Obs were enrolled as a control group. Read More

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October 2018

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney.

Am J Physiol Renal Physiol 2018 Nov 28. Epub 2018 Nov 28.

Institut für Vegetative Anatomie, Charité Universitätsmedizin Berlin, Germany.

Hypokalemia contributes to the progression of chronic kidney disease, while a definitive pathophysiogical theory to explain this remains to be established. K deficiency results in profound alterations of renal epithelial transport. These include an increase of salt reabsorption via the Na,Cl-cotransporter (NCC) of the distal convoluted tubule (DCT), which minimizes electroneutral K loss in downstream nephron segments. Read More

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November 2018

Hypokalemia Associated With a Claudin 10 Mutation: A Case Report.

Am J Kidney Dis 2018 Oct 25. Epub 2018 Oct 25.

Division of Nephrology, Department of Pediatrics, NYU Langone Health, New York, NY. Electronic address:

Hypokalemia of renal origin can arise from genetic abnormalities in a variety of transporters or channel proteins that mediate tubular handling of potassium. Recently, mutations in claudin 10 have been documented in patients with hypokalemia in association with a range of other electrolyte abnormalities and skin and sweat gland manifestations. We report a 12-year-old Hispanic boy who presented with anhydrosis, aptyalism, alacrima, hypokalemia, and hypocalciuria, in whom we detected a homozygous mutation in the claudin 10 gene. Read More

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October 2018

Association between hypokalemia and small bowel capsule endoscopy completion rates in patients in South China: A prospective single-center study.

Saudi J Gastroenterol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gastroenterology, Qingyuan People's Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China.

Background/aims: Approximately 20-30% of small bowel capsule endoscopies (SBCEs) do not reach the cecum at the completion of the examination. We aimed to determine whether hypokalemia influences the completion rate and small bowel transit time (SBTT) of SBCE.

Patients And Methods: From January to December 2017, 112 patients (18-75 years old) who underwent SBCE were assessed consecutively for enrolment in our study. Read More

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November 2018
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Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study.

Basic Clin Pharmacol Toxicol 2018 Nov 24. Epub 2018 Nov 24.

Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan.

Glycyrrhizin is used to treat chronic hepatitis, but it also plays an important role in pseudoaldosteronism. Multidrug resistance-associated protein 2 is important for glycyrrhizin excretion. Dysfunction of this transporter increases the serum levels of direct-bilirubin, glycyrrhizin, and its metabolites. Read More

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November 2018
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Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy.

Front Physiol 2018 7;9:1500. Epub 2018 Nov 7.

Department of Pharmacology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.

Routine use of diuretics and neurohumoral activation make hypokalemia (serum K < 3. 5 mM) a prevalent electrolyte disorder among heart failure patients, contributing to the increased risk of ventricular arrhythmias and sudden cardiac death in heart failure. Recent experimental studies have suggested that hypokalemia-induced arrhythmias are initiated by the reduced activity of the Na/K-ATPase (NKA), subsequently leading to Ca overload, Ca/Calmodulin-dependent kinase II (CaMKII) activation, and development of afterdepolarizations. Read More

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November 2018
2 Reads

Renal aspects of metabolic acid-base disorders in neonates.

Pediatr Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Lausanne University Medical School, CHUV-1011, Lausanne, Switzerland.

Acid-base homeostasis is one of the most tightly regulated systems in the body. Maintaining the acid-base balance is particularly challenging for preterm infants and growing neonates. The kidney, which represents the crucial ultimate line of defense against disturbances of acid-base balance, undergoes a complex maturation process during the transition from a fetal to an extra-uterine environment. Read More

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November 2018
11 Reads

Fanconi Syndrome.

Authors:
John W Foreman

Pediatr Clin North Am 2019 Feb;66(1):159-167

Department of Pediatrics, Duke University School of Medicine, Erwin Road, Durham, NC 27710, USA. Electronic address:

Fanconi syndrome, also known as the DeToni, Debré, Fanconi syndrome is a global dysfunction of the proximal tubule characterized by glucosuria, phosphaturia, generalized aminoaciduria, and type II renal tubular acidosis. Often there is hypokalemia, sodium wasting, and dehydration. In children, it typically is caused by inborn errors of metabolism, principally cystinosis. Read More

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February 2019
1 Read

Bartter Syndrome and Gitelman Syndrome.

Pediatr Clin North Am 2019 Feb;66(1):121-134

Department of Pediatrics, Inova Children's Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA; Division of Nephrology and Hypertension, Pediatric Specialists of Virginia, 3023 Hamaker Court, Suite 600, Fairfax, VA 22031, USA; Virginia Commonwealth School of Medicine, Richmond, VA, USA. Electronic address:

Bartter and Gitelman syndromes are conditions characterized by renal salt-wasting. Clinical presentations range from severe antenatal disease to asymptomatic with incidental diagnosis. Hypokalemic hypochloremic metabolic alkalosis is the common feature. Read More

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February 2019
3 Reads

Periodic paralysis with normokalemia in a patient with hyperthyroidism: A case report.

Medicine (Baltimore) 2018 Nov;97(46):e13256

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Thyrotoxic periodic paralysis is characterized by a sudden onset of hypokalemia and paralysis. This condition mainly affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle without typical symptoms such as palpitations, tremors, anxiety, and weight loss; this causes a difficulty in early diagnosis. Read More

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November 2018
8 Reads

Biliary tract exploration through a common bile duct incision or left hepatic duct stump in laparoscopic left hemihepatectomy for left side hepatolithiasis: which is better?: A single-center retrospective case-control study.

Medicine (Baltimore) 2018 Nov;97(46):e13080

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu.

Laparoscopic left hemihepatectomy (LLH) followed by biliary tract exploration is used to treat left-sided hepatolithiasis (LSH). The purpose of this study was to compare the efficacy of 2 methods of biliary tract exploration in LLH:biliary tract exploration through a common bile duct (CBD) incision (with T-tube drainage) or through the left hepatic duct (LHD) stump (without T-tube drainage).LSH patients (113 patients) were recruited retrospectively in our hospital from December 2008 to January 2016. Read More

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November 2018
6 Reads

Oral acyclovir induced hypokalemia and acute tubular necrosis a case report.

BMC Nephrol 2018 Nov 14;19(1):324. Epub 2018 Nov 14.

Servicio de Nefrología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Acyclovir is one of the most common prescribed antiviral drugs. Acyclovir nephrotoxicity occurs in approximately 12-48% of cases. It can present in clinical practice as acute kidney injury (AKI), crystal-induced nephropathy, acute tubulointerstitial nephritis, and rarely, as tubular dysfunction. Read More

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November 2018
2 Reads

A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration-resistant prostate cancer.

Cancer 2018 Nov 14. Epub 2018 Nov 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Background: Abiraterone acetate suppresses adrenal androgens and glucocorticoids through the inhibition of CYP17; however, given the risk of mineralocorticoid excess, it is administered with glucocorticoids. Herein, the authors performed a phase 2, single-arm study that was designed to assess the safety of abiraterone acetate without steroids in patients with castration-resistant prostate cancer.

Methods: Eligible patients had castration-resistant prostate cancer with controlled blood pressure and normal potassium. Read More

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November 2018
4 Reads

Thyrotoxic periodic paralysis complicated by life-threatening acute hypercapnic respiratory failure in a Chinese male with painless thyroiditis.

Am J Emerg Med 2018 Nov 7. Epub 2018 Nov 7.

Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Wenzhou 325027, China. Electronic address:

Context: Thyrotoxic periodic paralysis (TPP) is a relatively common complication seen in Asian hyperthyroid patients. However, it is a rare occurrence to find a TPP case comprised of acute hypercapnic respiratory failure in patients with painless thyroiditis.

Patient: A 29-year-old Chinese man presented with flaccid paralysis of all four limbs and he was brought to emergency room. Read More

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November 2018
1 Read

Intravascular Cooling Device Versus Esophageal Heat Exchanger for Mild Therapeutic Hypothermia in an Experimental Setting.

Anesth Analg 2018 Nov 9. Epub 2018 Nov 9.

From the Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany.

Background: Targeted temperature management is a standard therapy for unconscious survivors of cardiac arrest. To date, multiple cooling methods are available including invasive intravascular cooling devices (IVDs), which are widely used in the clinical setting. Recently, esophageal heat exchangers (EHEs) have been developed providing cooling via the esophagus that is located close to the aorta and inferior vena cava. Read More

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November 2018
2 Reads

Ghanaians Might Be at Risk of Excess Dietary Intake of Potassium Based on Food Supply Data.

J Nutr Metab 2018 17;2018:5989307. Epub 2018 Oct 17.

Department of Biological, Environmental & Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.

The World Health Organization (WHO) has highlighted the beneficial role of adequate intake of potassium (K) in combating the global burden of noncommunicable diseases (NCDs), mainly hypertension and cardiovascular diseases. Diets are the main source of K supply to humans and can contribute to both K deficiency (hypokalemia) and excess (hyperkalemia). While global attention is currently devoted to K deficiency, K excess can be even more dangerous and deserves equal attention. Read More

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October 2018
4 Reads

Keeping primary aldosteronism in mind: Deficiencies in screening at-risk hypertensives.

Surgery 2018 Nov 8. Epub 2018 Nov 8.

Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Primary aldosteronism is a common but underdiagnosed cause of hypertension. Patients with this disorder have worse morbidity compared with those with essential hypertension, but with timely diagnosis and appropriate intervention these patients are potentially cured and may have reversal of target organ damage. The goal of this study was to determine if hypertensive patients considered high risk were checked for primary aldosteronism. Read More

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November 2018
1 Read

Characteristics and Follow-Up of 13 pedigrees with Gitelman syndrome.

J Endocrinol Invest 2018 Nov 10. Epub 2018 Nov 10.

Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, 324, Jing 5 Road, Jinan, 250021, Shandong, China.

Context: Gitelman syndrome (GS) is clinically heterogeneous. The genotype and phenotype correlation has not been well established. Though the long-term prognosis is considered to be favorable, hypokalemia is difficult to cure. Read More

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November 2018
2 Reads

Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers.

Am J Transplant 2018 Nov 9. Epub 2018 Nov 9.

Section of HPB Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Liver transplantation is frequently associated with hyperkalemia, especially after graft reperfusion. Dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia/reperfusion injury and improves graft function, compared to conventional static cold storage (SCS). We examined the effect of DHOPE on ex situ and in vivo shifts of potassium and sodium. Read More

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November 2018
4 Reads

Renal Tubular Acidosis and Hypokalemic Paralysis as a First Presentation of Primary Sjögren's Syndrome.

Case Rep Nephrol 2018 16;2018:9847826. Epub 2018 Oct 16.

Pulmonology and Critical Care Unit, Department of Medicine, Chitwan Medical College, Bharatpur, Chitwan, Nepal.

Sjögren's syndrome is an autoimmune disease with multisystem involvement and varying clinical presentation. We report the clinical course and outcome of a case who presented with repeated episodes of hypokalemia mimicking hypokalemic periodic paralysis and metabolic acidosis, which was later diagnosed as distal renal tubular acidosis secondary to primary Sjögren's syndrome. A 50-year-old lady, who was previously diagnosed as hypokalemic periodic paralysis, presented with generalized weakness and fatigue. Read More

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October 2018
6 Reads

Renin dependent hypertension caused by accessory renal arteries.

Clin Hypertens 2018 1;24:15. Epub 2018 Nov 1.

Department of Medicine, Sarawak General Hospital, Ministry of Health Malaysia, Jalan Hospital, 93586 Kuching, Sarawak Malaysia.

Background: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants in the vascular anatomy which are often thought to be innocuous but in some circumstances can cause renovascular hypertension leading to secondary hyperaldosteronism.

Case Presentation: We report 2 cases of hypertension with secondary hyperaldosteronism associated with accessory renal arteries. Read More

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November 2018
5 Reads

Two neonates with Bartter syndrome.

J Pak Med Assoc 2018 Nov;68(11):1721-1723

Children hospital, Pakistan Institute of Medical Sciences, Islamabad.

Bartter syndrome is an autosomal recessive disorder caused by gene mutations that involve hypokalaemia, hypochloraemia and metabolic alkalosis along with raised serum renin, hyperaldosteronism and normal blood pressure. We report two cases of neonatal Bartter syndrome. Case 1 was a product of non-consanguineous marriage and mother had unexplained polyhydramnios in pregnancy while case 2 was a product of consanguineous marriage. Read More

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November 2018
5 Reads

Complicated Gitelman syndrome and autoimmune thyroid disease: a case report with a new homozygous mutation in the SLC12A3 gene and literature review.

BMC Endocr Disord 2018 Nov 8;18(1):82. Epub 2018 Nov 8.

The Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Background: Gitelman syndrome (GS) is an inherited autosomal recessive renal tubular disorder characterized by low levels of potassium and magnesium in the blood, decreased excretion of calcium in the urine, and elevated blood pH. GS is caused by an inactivating mutation in the SLC12A3 gene, which is located on the long arm of chromosome 16 (16q13) and encodes a thiazide-sensitive sodium chloride cotransporter (NCCT).

Case Presentation: A 45-year-old man with Graves' disease complicated by paroxysmal limb paralysis had a diagnosis of thyrotoxic periodic paralysis for 12 years. Read More

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November 2018
1 Read

Serum electrolyte imbalance and prognostic factors of postoperative death in adult traumatic brain injury patients: A prospective cohort study.

Medicine (Baltimore) 2018 Nov;97(45):e13081

Electrolyte imbalances are common in traumatic brain injury. It shares the cause of perioperative morbidity and mortality. Types of intravenous fluid resuscitation, osmotic diuretics, massive blood loss, and intracranial pathology were considered as the potential factors to worsen electrolyte abnormalities in these patients. Read More

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November 2018
2 Reads

Anti-Voltage-Gated Potassium Channel Antibody Syndrome: A Rare Cause of Hyponatremia in Intensive Care Unit.

Indian J Crit Care Med 2018 Oct;22(10):746-748

Department of Anesthesiology, IMS BHU, Varanasi, Uttar Pradesh, India.

Hyponatremia causing seizure is a common cause for admission in the critical care unit. Here, we describe a peculiar case of seizure due to hyponatremia, associated with anti-voltage-gated potassium channel antibody syndrome. This case emphasizes that how a proper workup can unveil unusual but potentially treatable causes of hyponatremia. Read More

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October 2018
1 Read

Paraquat poisoning in Western French Guyana: a public health problem persisting ten years after its withdrawal from the French market.

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):7034-7038

Emergency Department, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guyana.

Objective: Paraquat poisoning has almost disappeared from metropolitan France following its ban from the European market ten years ago. However, due to neighboring countries still authorizing paraquat use, French Guyana seems in a different situation. Here we aimed to report a series of paraquat-poisoned patients admitted to the emergency department of the Western French Guyana Hospital in Saint-Laurent du Maroni, to raise awareness of national health authorities on this persistent major issue. Read More

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October 2018
7 Reads

Analysis of Risk Factors with Hospital Mortality in Pedestrian Injured Patients; A Dataset Analysis of a Level-I Trauma Center in Southern Iran.

Bull Emerg Trauma 2018 Oct;6(4):349-354

Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: To determine the indicators predicting the hospital mortality in pedestrian injured patients admitted to a level I trauma center in Southern Iran.

Methods: This case control study was conducted in a Level-I trauma hospital in Shiraz. We selected all survived pedestrians who were admitted in the hospital with duration of admission more than 24 hours in one year from March 2016 to February 2017 as control group and compared with all non-survived pedestrian patients who expired in the hospital according to clinical from March 2012 to February 2017. Read More

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October 2018
1 Read

Significance of M2 macrophage in tubulointerstitial disease secondary to primary Sjogren's disease.

Ren Fail 2018 Nov;40(1):634-639

c Department of Nephrology , Clinical Medical College, Yangzhou University , Yangzhou , China.

Objective: M2 Macrophages could improve tubulointerstitial disease in animal models. HIF-1αpromotes macrophage polarization and is involved in tubular injury. The study aims to observe the clinicopathologic significance of M2 macrophage and HIF-1α in tubulointerstitial injury secondary to primary Sjogren's disease. Read More

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November 2018
7 Reads
0.775 Impact Factor

Exercise activates vagal induction of dopamine and attenuates systemic inflammation.

Brain Behav Immun 2019 Jan 27;75:181-191. Epub 2018 Oct 27.

Department of Surgery, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA; Center for Immunity and Inflammation, Rutgers-New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ 07103, USA. Electronic address:

Physical exercise is one of the most important factors improving quality of life, but it is not feasible for patients with morbidity or limited mobility. Most previous studies focused on high-intensity or long-term exercise that causes metabolic stress or physiological adaption, respectively. Here, we studied how moderate-intensity swimming affects systemic inflammation in 6-8 week old C57BL/6J male mice during endotoxemia. Read More

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January 2019
11 Reads

Ectopic adrenocorticotropic hormone syndrome associated with olfactory neuroblastoma: acquirement of adrenocorticotropic hormone expression during disease course as shown by serial immunohistochemistry examinations.

J Int Med Res 2018 Nov;46(11):4760-4768

1 Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo, Japan.

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract and is derived from the olfactory epithelium. Because the paranasal sinus is not a common site of EAS, the development of ONB in patients with EAS is rare. Read More

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November 2018
4 Reads

Pancreatic VIPomas from China: Case reports and literature review.

Pancreatology 2018 Oct 26. Epub 2018 Oct 26.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) are rare neuroendocrine tumors that often present as watery diarrhea, hypokalemia, and achlorhydria or hypochlorhydria. In this study, we present our institutional experience of diagnosis and treatment of VIPomas, along with a review of the Chinese literature since 1980. Patient #1, diagnosed in 1984 and with intact clinical records, shows the natural history of this disease. Read More

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October 2018
3 Reads

Bartter Syndrome and GH Deficiency: three siblings with a novel CLCNKB mutation.

Pediatr Int 2018 Nov 2. Epub 2018 Nov 2.

Dipartimento di Pediatria, Università degli Studi di Pavia (Pavia, IT).

Background: Bartter's syndrome (BS) is a rare genetic salt-wasting renal disease characterized by hypokalemia and metabolic alkalosis, which presents with a wide phenotypic variation. Failure to thrive is a common clinical feature of BS, but growth is usually improved by an adequate treatment and correction of salt unbalance. However, some cases of growth hormone deficiency (GHD) in BS children have been described previously. Read More

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November 2018
2 Reads

Acquired Gitelman Syndrome Secondary to Bendamustine Use.

R I Med J (2013) 2018 Nov 1;101(9):36-38. Epub 2018 Nov 1.

Division of Kidney Diseases and Hypertension, Brown Medicine, Alpert Medical School of Brown University, Providence, RI.

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November 2018
1 Read

Distal renal tubular acidosis secondary to vesico-ureteric reflux: A case report with review of literature.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1240-1244

Bombay Hospital and Research Center, Indore, Madhya Pradesh, India.

Vesicoureteric reflux (VUR) is the most common congenital anomaly of the urinary tract that occurs in 30%-50% of children presenting with recurrent urinary tract infections. Long-standing untreated VUR results in renal scarring and hydronephrotic changes ultimately leading to chronic renal failure and arterial hypertension. However, it may also result in diffuse tubulopathy compromising the concentrating capacity of tubules and urinary acidification defects. Read More

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November 2018
2 Reads

An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1216-1219

Department of Nephrology, Government Medical College and Super Specialty Hospital, Nagpur, Maharashtra, India.

Primary hyperparathyroidism (PHPT) usually presents with hypercalcemia related symptoms and signs. Kidneys play an important role in calcium homeostasis. PHPT has been reported to be associated with hyperchloremia, defective urinary acidification, and renal tubular acidosis (RTA). Read More

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November 2018
3 Reads

[Etiology, Prognosis and Risk Factors of 181 Adult Community-acquired Acute Bacterial Meningitis].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Sep;49(5):808-811

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To understand the etiology, clinical prognosis and risk factors of adult community-acquired acute bacterial meningitis (ABM) and provide the evidence for clinical diagnosis and treatment.

Methods: We performed a retrospective study of 181 clinically diagnosed hospitalized patients with community-acquired adult ABM from Jan.2010 to Jan. Read More

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September 2018
1 Read

Reninoma: a rare cause of curable hypertension.

Korean J Pediatr 2018 Oct 29. Epub 2018 Oct 29.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Refractory hypertension in children is often secondary hypertension, which is potentially curable. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension, usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures hypertension. Read More

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October 2018
7 Reads

Multimodality detection of multiple left ventricular diverticula: A case report and brief review of the literature.

Echocardiography 2018 Oct 30. Epub 2018 Oct 30.

Division of Cardiovascular Disease, Department of Medicine, University of Missouri- Columbia, Columbia, Missouri.

Left ventricular diverticula (LVD) are rare congenital anomalies usually detected incidentally in the adult population. Most commonly, they are found as a single left ventricular diverticulum in association with other congenital abnormalities but multiple LVD are exceedingly rare. We are describing a patient who was found to have multiple LVD on multimodality imaging studies. Read More

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October 2018
5 Reads

Efficacy and safety of abiraterone acetate plus prednisone in Japanese patients with newly diagnosed, metastatic hormone-naïve prostate cancer: a subgroup analysis of LATITUDE, a randomized, double-blind, placebo-controlled, Phase 3 study.

Jpn J Clin Oncol 2018 Nov;48(11):1012-1021

Department of Breast and Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.

Objectives: To evaluate the efficacy and safety of abiraterone acetate plus prednisone (AAP) plus androgen-deprivation therapy (ADT) in Japanese subgroup with newly diagnosed, metastatic hormone-naïve prostate cancer (mHNPC) from Phase 3, randomized, global LATITUDE study.

Methods: Men with mHNPC having ≥2 of 3 high-risk factors (Gleason score ≥8, ≥3 bone lesions or measurable visceral metastases) randomly received abiraterone acetate 1000-mg+ prednisone 5-mg+ADT (AAP group) or ADT+Placebos (Placebo group). Coprimary endpoints were overall survival (OS) and radiographic progression-free survival (rPFS). Read More

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November 2018
9 Reads