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    The value of real-time continuous glucose monitoring in premature infants of diabetic mothers.
    PLoS One 2017 16;12(10):e0186486. Epub 2017 Oct 16.
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Read More

    Clinical characteristics of acute fatty liver of pregnancy in a tertiary Indonesian hospital.
    J Matern Fetal Neonatal Med 2017 Oct 16:1-191. Epub 2017 Oct 16.
    a Department Obstetrics & Gynaecology , Universitas Airlangga , RSUD dr. Soetomo , Surabaya , Indonesia.
    Acute fatty liver of pregnancy (AFLP) is a rare, often autosomal recessive disorder with a major risk for maternal and perinatal mortality and morbidity. In order to achieve a more favorable outcome, awareness of its clinical signs and symptoms and early recognition are of pivotal importance. Over a 5-year period 18 patients were diagnosed with AFLP (one twin, 19 babies). Read More

    The effects of add-on exenatide to insulin on glycemic variability and hypoglycemia in patients with type 1 diabetes mellitus.
    J Endocrinol Invest 2017 Oct 14. Epub 2017 Oct 14.
    Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
    Objective: To investigate the effect of add-on exenatide to insulin on glycemic excursion and the counter-regulatory hormone in response to hypoglycemia in patients with type 1 diabetes mellitus (T1DM).

    Methods: 30 patients with T1DM were recruited and randomly assigned to exenatide + insulin-treated group (group 1, n = 15) or insulin-only-treated group (group 2, n = 15) for 4 weeks. All patients had continuous glucose monitor system (CGMS) applied at before (week-0) and after (week-4) treatment to evaluate the glycemic variability. Read More

    Sulfonylureas as Initial Treatment for Type 2 Diabetes and the Risk of Severe Hypoglycemia.
    Am J Med 2017 Oct 12. Epub 2017 Oct 12.
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada; Department of Medicine, McGill University, Montreal, Canada. Electronic address:
    Purpose: The magnitude of the risk of severe hypoglycemia associated with sulfonylureas as the initial treatment for type 2 diabetes in the real-world setting is unknown. We assessed the risk of severe hypoglycemia associated with initiating monotherapy with sulfonylurea compared to metformin for the treatment of type 2 diabetes.

    Methods: Using the UK Clinical Practice Research Datalink and Hospital Episode Statistics linked to the Office for National Statistics, we identified a cohort of patients with type 2 diabetes who initiated sulfonylureas or metformin monotherapy between April 1, 1998 and December 31, 2012, with follow-up until December 31, 2013. Read More

    Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
    JIMD Rep 2017 Oct 14. Epub 2017 Oct 14.
    Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
    We report an 8-month-old infant with decreased consciousness after a febrile episode and reduced oral intake. He was profoundly acidotic but his lactate was normal. Serum triglycerides were markedly elevated and HDL cholesterol was very low. Read More

    12-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia.
    Diabetes Care 2017 Oct 13. Epub 2017 Oct 13.
    Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA
    Objective: Artificial pancreas (AP) systems are best positioned for optimal treatment of type 1 diabetes (T1D) and are currently being tested in outpatient clinical trials. Our consortium developed and tested a novel adaptive AP in an outpatient, single-arm, uncontrolled multicenter clinical trial lasting 12 weeks.

    Research Design And Methods: Thirty adults with T1D completed a continuous glucose monitor (CGM)-augmented 1-week sensor-augmented pump (SAP) period. Read More

    Hypoglycaemia causes both daytime and nighttime QTc interval prolongation in patients with type 2 diabetes receiving insulin treatment.
    Diabetes Metab 2017 Oct 10. Epub 2017 Oct 10.
    First Department of Propaedeutic Medicine, National and Kapodistrian University of Athens Medical School, Laiko General Hospital, 17, Ag. Thoma St, 11527 Athens, Greece.

    Efficacy and safety of pramlintide injection adjunct to insulin therapy in patients with type 1 diabetes mellitus: a systematic review and meta-analysis.
    Oncotarget 2017 Sep 8;8(39):66504-66515. Epub 2017 Mar 8.
    Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin, China.
    Aims: We aim to assess the efficacy and safety of pramlintide plus insulin therapy in patients with type 1 diabetes.

    Methods: We included clinical studies comparing pramlintide plus insulin to placebo plus insulin. Efficacy was reflected by glycemic control and reduction in body weight and insulin use. Read More

    No disparity of the efficacy and all cause mortality between Asian and non-Asian type 2 diabetes patients with SGLT2 inhibitors treatment: A meta-analysis.
    J Diabetes Investig 2017 Oct 13. Epub 2017 Oct 13.
    Peking University People's Hospital, Endocrine& Metabolism Department, 100044, Beijing, China.
    Aims: To evaluate whether there is disparity of the efficacy and all cause mortality and other adverse effects between Asian and non-Asian patients with SGLT2 inhibitors treatment.

    Methods: Randomized clinical trials publicly available before January 2017, comparing SGLT2 inhibitors treatment with placebo in type 2 diabetes patients were identified. The registration number of this meta-analysis is CRD42016047666. Read More

    Impact of Insulin Detemir Administration Time on Hypoglycemia Rates in Hospitalized Patients.
    Pharmacotherapy 2017 Oct 13. Epub 2017 Oct 13.
    Division of Adult Medicine, Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Abilene, Texas.
    Study Objective: To determine if insulin detemir administration time affects the frequency of hypoglycemia (blood glucose level <70 mg/dL) in hospitalized patients.

    Design: Retrospective cohort study.

    Patients: A total of 357 adults (aged 18-89 yrs) who received insulin detemir for at least 48 hours while hospitalized between January 1, 2014, and December 31, 2015, were included. Read More

    Management of diabetic ketosis and ketoacidosis with intramuscular regular insulin in a low-resource family medicine setting.
    J Family Med Prim Care 2017 Jan-Mar;6(1):25-28
    Department of Family Medicine, Low Cost Effective Care Unit, Christian Medical College, Vellore, Tamil Nadu, India.
    Background: India is facing an epidemic of diabetes mellitus (DM). Effective management of complications of DM is a challenge in resource-poor areas of India. This study addresses the need to explore low-cost methods to manage diabetic ketosis (DK) and diabetic ketoacidosis (DKA). Read More

    Diabetes and Ramadan: A concise and practical update.
    J Family Med Prim Care 2017 Jan-Mar;6(1):11-18
    Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan.
    Despite the fact that the month of Ramadan includes 29-30 days and the duration of fasting for each day can last for between 12 and 16 h, it was estimated that a large number of individuals with diabetes do fast during Ramadan. In light of recent advancement of new pharmacological agents, drugs such as vildagliptin, sitagliptin, and liraglutide were found to be safe to use during this month of fasting. These therapeutic agents can also be used in combination with metformin. Read More

    Pasireotide and octreotide in the treatment of severe late dumping syndrome.
    Clin Case Rep 2017 Oct 22;5(10):1608-1611. Epub 2017 Aug 22.
    Oxford Centre for Diabetes, Endocrinology and MetabolismChurchill HospitalUniversity of OxfordOxfordUK.
    Hypoglycemia due to late dumping is a significant problem postoesophagectomy but may not always be diagnosed sufficiently early. It can be difficult to treat and may severely compromise quality of life. The combination of diazoxide and octreotide or more probably pasireotide may transform the patient's life and should be considered in all problematic cases. Read More

    Clinical characteristics of septo-optic dysplasia accompanied by congenital central hypothyroidism in Japan.
    Clin Pediatr Endocrinol 2017 28;26(4):207-213. Epub 2017 Sep 28.
    Department of Pediatrics, Jichi Children's Medical Center Tochigi, Tochigi, Japan.
    Septo-optic dysplasia (SOD) is a congenital anomaly in which agenesis of the septum pellucidum and optic nerve hypoplasia are accompanied by hypopituitarism. Typically, the symptoms develop in 3 organs, the brain, eyes, and pituitary, and approximately one third of the patients present with all of the three cardinal features. The diagnostic criteria for SOD were established in Japan in 2015. Read More

    Diabetes in older people: position statement of The Hong Kong Geriatrics Society and the Hong Kong Society of Endocrinology, Metabolism and Reproduction.
    Hong Kong Med J 2017 Oct;23(5):524-33
    Department of Medicine and Geriatrics, Pok Oi Hospital, Yuen Long, Hong Kong.
    Following a survey on the clinical practice of geriatricians in the management of older people with diabetes and a study of hypoglycaemia in diabetic patients, a round-table discussion with geriatricians and endocrinologists was held in January 2015. Consensus was reached for six domains specifically related to older diabetic people: (1) the considerations when setting an individualised diabetic management; (2) inclusion of geriatric syndrome screening in assessment; (3) glycaemic and blood pressure targets; (4) pharmacotherapy; (5) restrictive diabetic diet; and (6) management goals for nursing home residents. Read More

    Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabetes.
    BMJ Open 2017 Oct 12;7(10):e017989. Epub 2017 Oct 12.
    NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.
    Purpose: This is a retrospective cohort study using observational data from anonymised primary care records. We identify and extract all patients with type 2 diabetes and associated clinical data from the Clinical Practice Research Datalink (CPRD) to inform models of disease progression and stratification of treatment.

    Participants: Data were extracted from CPRD on 8 August 2016. Read More

    [Neonatal Morbidity and Gestational Diabetes: Coincidence or Consequence of the 2011 Protocol].
    Acta Med Port 2017 Sep 29;30(9):589-598. Epub 2017 Sep 29.
    Departamento de Pediatria. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal; Unidade de Neurodesenvolvimento e Autismo do Centro de Desenvolvimento da Criança e Centro de Investigação e Formação Clínica. Hospital Pediátrico de Coimbra. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
    Introduction: Gestational diabetes is one of the diseases associated with pregnancy with higher rate of complications. Despite being a transitory condition, short and long term complications related to gestational diabetes have been described. There is scientific evidence to say that good metabolic control decreases perinatal complications. Read More

    Compound heterozygosity for two GHR missense mutations in a patient affected by Laron Syndrome: a case report.
    Ital J Pediatr 2017 Oct 12;43(1):94. Epub 2017 Oct 12.
    Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
    Background: Mutations localized in the Growth Hormone Receptor (GHR) gene are often associated with the pathogenesis of Laron Syndrome, an autosomal recessive hereditary disorder characterized by severe growth retardation. Biochemically, patients present normal to high circulating GH levels, in presence of very low or undetectable IGF-I levels, which do not rise after rhGH treatment.

    Case Presentation: We describe the case of a 3. Read More

    Safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus: a 1-year post-marketing surveillance in Japan.
    Curr Med Res Opin 2017 Oct 13:1-22. Epub 2017 Oct 13.
    a Ikuyaku. Integrated Value Development Division , Mitsubishi Tanabe Pharma Corporation , Osaka , Japan.
    Objective To evaluate the safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus (T2DM) in clinical settings. Methods We conducted a 1-year post-marketing surveillance (PMS) of canagliflozin in almost all the elderly patients (≥65 years old) with T2DM who began taking canagliflozin during the first 3 months after its launch in Japan. The main outcomes included the incidences of adverse drug reactions (ADRs), serious ADRs and the changes of laboratory tests as well as efficacy variables. Read More

    The diagnosis and management of congenital and adult-onset hyperinsulinism (nesidioblastosis) - literature review.
    Pol J Pathol 2017 ;68(2):97-101
    Congenital and adult-onset hyperinsulinism (CHI) must be taken under consideration in the differential diagnosis of hypoglycaemia symptoms with endogenous hyperinsulinism, especially in cases in which there was failure to find an insulinoma. Histological examination is necessary for a definitive diagnosis. CHI is a disorder with three histopathological variants: focal CHI, diffuse CHI, and atypical CHI. Read More

    Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn.
    Cochrane Database Syst Rev 2017 Oct 12;10:CD011048. Epub 2017 Oct 12.
    Department of Paediatrics (Neonatal Unit), Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria, 121001NG.
    Background: Exchange blood transfusion (EBT) is a form of whole blood transfusion in which the total blood volume is replaced within a few hours. In perinatal and neonatal medicine, EBT is most often used in the management of severe anaemia or severe hyperbilirubinaemia in the first week of life. Hypocalcaemia, one of the common morbidities associated with EBT, is thought to arise from the chelating effects of the citrate commonly used as an anticoagulant in the donor's blood. Read More

    Managing diabetes at high altitude: personal experience with support from a Multidisciplinary Physical Activity and Diabetes Clinic.
    BMJ Open Sport Exerc Med 2017 16;3(1):e000238. Epub 2017 Aug 16.
    Department Diabetes and Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
    Objective: Physical activity is important for well-being but can be challenging for people with diabetes. Data informing support of specialist activities such as climbing and high-altitude trekking are limited. A 42-year-old man with type 1 diabetes (duration 30 years) attended a Multidisciplinary Physical Activity and Diabetes Clinic planning to climb Mont Blanc during the summer and trek to Everest Base Camp in the autumn. Read More

    A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: A Case Report with Immunohistochemistry and a Western Blot Analysis.
    Intern Med 2017 Oct 11. Epub 2017 Oct 11.
    Department of Breast Surgery, Fujita Health University School of Medicine, Japan.
    A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Read More

    A case of Insulinoma with a History of Epilepsy: Still a Possible Misleading Factor in the Early Diagnosis of Insulinoma.
    Intern Med 2017 Oct 11. Epub 2017 Oct 11.
    Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Japan.
    A delayed diagnosis of insulinoma remains a clinical issue. Hypoglycemic symptoms can mimic neuropsychiatric disorders such as epilepsy. A 27-year-old woman with a history of epilepsy and anti-epileptic drugs (AEDs) developed repeated seizures and neuropsychiatric symptoms after a 9-year asymptomatic interval. Read More

    Early neonatal hypoglycemia: incidence of and risk factors. A cohort study using universal point of care screening.
    J Matern Fetal Neonatal Med 2017 Oct 11:1-171. Epub 2017 Oct 11.
    b Shaare Zedek Medical Center , Jerusalem , Israel.
    Objective: To determine the true incidence of early neonatal hypoglycemia and to confirm potential risk factors.

    Study Design: The study was conducted at tertiary Medical Center in Israel, between June and September 2014. First blood glucose concentrations of all infants admitted to the nursery were measured using a "point of care" analyzer (Accu-Chek). Read More

    Failed titration of endocrine replacement therapy: diagnostic significance.
    Br J Hosp Med (Lond) 2017 Oct;78(10):578-579
    Retired Geriatrician, c/o Manchester Medical Society, Manchester M13 9PL.
    Unsuccessful titration of endocrine replacement therapy may signify the coexistence of an unrecognized disorder which alters the response to replacement therapy. Examples include recurrent hypoglycaemia when type 1 diabetes mellitus coexists with either Addison's disease or coeliac disease. Recurrent Addisonian crisis occurs when Addison's disease coexists with thyrotoxicosis. Read More

    The burden of severe hypoglycemia in type 1 diabetes.
    Curr Med Res Opin 2017 Oct 11:1-16. Epub 2017 Oct 11.
    b Novo Nordisk Inc. , 800 Scudders Mill Rd , Plainsboro , NJ , 08536 , USA.
    Aims: Approximately 1.25 million people in the United States have type 1 diabetes mellitus (T1DM), a chronic metabolic disease that develops from the body's inability to produce insulin, and requires life-long insulin therapy. Poor insulin adherence may cause severe hypoglycemia (SHO), leading to hospitalization and long-term complications; these, in turn, drive up costs of SHO and T1DM overall. Read More

    Dietary Therapy for Von Gierke's Disease: A Case Report.
    Cureus 2017 Aug 8;9(8):e1548. Epub 2017 Aug 8.
    Department of Oncology, Jinnah Post Graduate Medical Centre, Karachi, Pakistan.
    Von Gierke's disease, also known as glycogen storage disease (GSD) type 1A, is an autosomal recessive disease in which there is an inability to cleave glycogen to glucose because of a glucose 6 phosphate deficiency resulting in hypoglycemia and lactic acidosis. The patient may present with hepatomegaly and signs and symptoms of hypoglycemia. We diagnosed a case of Von Gierke's disease in a seven-month-old female infant who was admitted for abdominal distension, vomiting, and lethargy for a duration of four months with characteristic rounded doll's face, fatty cheeks, protuberant abdomen, and massive hepatomegaly. Read More

    Clinical considerations for use of insulin degludec/insulin aspart in Japanese patients.
    Expert Opin Biol Ther 2017 Oct 11. Epub 2017 Oct 11.
    d Medical & Scientific Affairs Department , Novo Nordisk Pharma Ltd ., Tokyo , Japan.
    Introduction: Co-formulation of basal and bolus insulin components provides a simpler regimen for patients with type 2 diabetes than separate basal-bolus treatment. However, conventional premixed insulin products include a suboptimal protaminated basal component that requires resuspension prior to injection. Insulin degludec/insulin aspart (IDegAsp) is the first soluble co-formulation of a basal insulin with an ultra-long duration of action (IDeg) and a rapid-acting bolus insulin (IAsp) in a single injection. Read More

    The burden of severe hypoglycemia in type 2 diabetes.
    Curr Med Res Opin 2017 Oct 11:1-19. Epub 2017 Oct 11.
    b Novo Nordisk Inc. , 800 Scudders Mill Rd , Plainsboro , NJ , 08536 , USA.
    Aims: More than 29 million people in the United States have type 2 diabetes mellitus (T2DM), a chronic metabolic disorder characterised by a progressive deterioration of glucose control, which eventually requires insulin. Abnormally low levels of blood glucose, a feared side effect of insulin treatment, may cause severe hypoglycemia (SHO), leading to emergency department (ED) admission, hospitalization, and long-term complications; these, in turn, drive up the costs of T2DM. This study's objective was to estimate the prevalence and costs of SHO-related hospitalizations and their additional longer-term impact on patients with T2DM using insulin. Read More

    Insulin Regimens to Treat Hyperglycemia in Hospitalized Patients on Nutritional Support: Systematic Review and Meta-Analyses.
    Ann Nutr Metab 2017 Oct 6;71(3-4):183-194. Epub 2017 Oct 6.
    Background: The best insulin regimen to treat hyperglycemia in hospitalized patients on nutritional support (NS) is unclear.

    Methods: We searched electronic databases to identify cohort studies or randomized clinical trials in order to evaluate the efficacy of different insulin regimens used to treat hyperglycemia in hospitalized patients on NS on diverse outcomes: mean blood glucose (MBG), hypoglycemia, length of stay in hospital, and mortality.

    Results: Seventeen studies from a total of 5,030 were included. Read More

    Neonatal Morbidity and Maternal Complication Rates in Women With a Delivery Body Mass Index of 60 or Higher.
    Obstet Gynecol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Obstetrics, Gynecology, and Women's Health and the Department of Biostatistics, University of Minnesota, and the Department of Obstetrics and Gynecology, Hennepin County Medical Center, Minneapolis, Minnesota.
    Objective: To investigate neonatal morbidity and maternal complication rates with delivery body mass index (BMI) 60 or greater.

    Methods: This retrospective, multicenter cohort study included singleton pregnancies between 23 and 42 weeks of gestation from January 2005 to April 2016. Women with BMI 60 or greater were compared with a random sample of women with BMI 30-59. Read More

    Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families.
    J Pediatr Endocrinol Metab 2017 Oct 9. Epub 2017 Oct 9.
    Background: Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare inherited metabolic disorder characterized by recurrent episodes of hypoglycemia, ketosis and lactic acidosis. FBPase is encoded by FBP1 gene and catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate in the last step of gluconeogenesis. We report here FBP1 mutations in nine consanguineous Pakistani families affected with FBPase deficiency. Read More

    Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes.
    Front Neurosci 2017 25;11:529. Epub 2017 Sep 25.
    Department of Radiology, Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, MN, United States.
    In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ± 14 years old). Read More

    Antidiabetic therapies and male reproductive function: where do we stand?
    Reproduction 2017 Oct 9. Epub 2017 Oct 9.
    S Amaral, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Diabetes mellitus has been increasing at alarming rates in recent years, thus jeopardizing human health worldwide. Several antidiabetic drugs have been introduced in the market to manage glycemic levels, proven effective in avoiding, minimizing or preventing the appearance or development of diabetes mellitus-related complications. However, and despite the established association between such pathology and male reproductive dysfunction, the influence of these therapeutic interventions on such topic have been scarcely explored. Read More

    [Overgrowth in children and in adults: novel clinical view, novel genes, novel phenotypes].
    Cas Lek Cesk 2017 ;156(5):233-240
    Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Read More

    Hypoglycaemia in the Newborn.
    Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Sep;38(2):79-84
    Aim: Severe neonatal hypoglycaemia (HG) leads to neurologic damage, mental retardation, epilepsy, impaired cardiac performance and muscle weakness. The aim was to assess the frequency and severity of HG in a population of newborns.

    Patients And Methods: We investigated 739 patients with neonatal hypoglycaemia (HG) (M:F=370:369) born at the University Clinic for Gynaecology and Obstetritics in Skopje in the period 2014-2016 and treated at the neonatal intensive care unit (NICU). Read More

    Fighting type-2 diabetes: present and future perspectives.
    Curr Med Chem 2017 Oct 9. Epub 2017 Oct 9.
    Beijing Key Laboratory of Diabetic Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 100149. China.
    Background: Type-2 diabetes mellitus accounts for 80-90% of diabetic patients. So far, the treatment of diabetes mainly aims at elevating insulin level and lowering glucose level in the peripheral blood and mitigating insulin resistance. Physiologically, insulin secretion from pancreatic β cells is delicately regulated. Read More

    Acceptability of Implantable Continuous Glucose Monitoring Sensor.
    J Diabetes Sci Technol 2017 Oct 1:1932296817735123. Epub 2017 Oct 1.
    3 Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
    Background: Real-time continuous glucose monitoring is associated with significant benefits for diabetes management. Implantable sensors could overcome some challenges reportedly associated with device visibility, psychosocial functioning and sensor durability.

    Methods: A psychosocial assessment was conducted to determine acceptability and impact of an implantable continuous glucose monitoring (CGM) sensor as part of the PRECISE trial. Read More

    Comparison of perinatal outcomes in late preterm birth between singleton and twin pregnancies.
    Obstet Gynecol Sci 2017 Sep 18;60(5):421-426. Epub 2017 Sep 18.
    Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
    Objective: To determine whether late preterm twin neonates have a more favorable perinatal outcome than singleton late preterm neonates.

    Methods: We studied 401 late preterm births between 34+0 and 36+6 weeks of gestation, from January 2011 to December 2014 in our institution. We compared the maternal and neonatal characteristics and perinatal outcomes between singleton and twin pregnancies. Read More

    Comparative Evaluation of Safety and Efficacy of Glimepiride and Sitagliptin in Combination with Metformin in Patients with Type 2 Diabetes Mellitus: Indian Multicentric Randomized Trial - START Study.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):745-750
    Consultant Cardiologist, Apollo Hospitals International Limited, Ahmedabad, Gujarat, India.
    Background And Objective: Modern sulfonylureas like glimepiride offer effective glycemic control with extrapancreatic benefits and good tolerability. The objective of the present study was to evaluate and compare safety and efficacy of glimepiride and sitagliptin in combination with metformin in patients with type 2 diabetes mellitus (T2DM).

    Methods: In this open-label, randomized, comparative, multicenter study, a total of 305 T2DM patients who were either drug naïve or uncontrolled on metformin were randomized to glimepiride 1 or 2 mg/sustained-release metformin 1000 mg once daily (glimepiride group, n = 202) or sitagliptin 50 mg/metformin 500 mg twice daily (sitagliptin group, n = 103) for 12 weeks. Read More

    "Riding High on Low Fuel" - Our Experience with Endogenous Hyperinsulinemic Hypoglycemia.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):655-659
    Department of Endocrinology, St. John's Medical College, Bengaluru, Karnataka, India.
    Introduction: Endogenous hyperinsulinemic hypoglycemia (EHH) is a condition in which the insulin levels are inappropriately high in the presence of low plasma glucose.

    Materials And Methods: We did a retrospective analysis of case records of those patients admitted and evaluated for EHH from June 2004 to June 2016 in our center, excluding those that were diagnosed with reactive hypoglycemia. We collected data regarding demographics, clinical presentation, laboratory results, localization techniques, and treatment administered. Read More

    Clinical profile of diabetes at diagnosis among children and adolescents at an endocrine clinic in Ghana.
    World J Diabetes 2017 Sep;8(9):429-435
    International Diabetes Federation Life for a Child Program, Glebe, NSW 2037, Australia.
    Aim: To determine the clinical features of diabetes in children and adolescents in Ghana.

    Methods: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016.

    Results: One hundred and six subjects presented with diabetes. Read More

    Reported gastroparesis in adults with type 1 diabetes (T1D) from the T1D Exchange clinic registry.
    J Diabetes Complications 2017 Sep 6. Epub 2017 Sep 6.
    Jaeb Center for Health Research, Tampa, FL, United States.
    Objective: To better understand the prevalence and impact of gastroparesis in the T1D Exchange clinic registry database.

    Methods: The analysis included 7107 adult participants with T1D across 45 sites (median age 46years. and median duration 24years). Read More

    Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
    Bioorg Med Chem 2017 Sep 21. Epub 2017 Sep 21.
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
    The discovery of a novel series of β-methyltryptophan (β MeTrp) derivatives as selective and orally active non-peptide somatostatin receptor 2 (SSTR2) agonists for the treatment of Type 2 diabetes is described. In our previous research, Compound A, β-MeTrp derivative with highly potent and selective SSTR2 agonistic activity IC50 (SSTR2/SSTR5)=0.3/>100 (nM), was identified asa drug candidate for treatment of Type 2 diabetes which lowers significantly plasma glucose level in Wistar fatty rats in its oral administrations. Read More

    Patients with glycogen storage diseases undergoing anesthesia: a case series.
    BMC Anesthesiol 2017 Oct 6;17(1):134. Epub 2017 Oct 6.
    Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Glycogen storage diseases are rare genetic disorders of glycogen synthesis, degradation, or metabolism regulation. When these patients are subjected to anesthesia, perioperative complications can develop, including hypoglycemia, rhabdomyolysis, myoglobinuria, acute renal failure, and postoperative fatigue. The objective of this study was to describe the perioperative course of a cohort of patients with glycogen storage diseases. Read More

    Sirolimus precipitating diabetes mellitus in a patient with congenital hyperinsulinaemic hypoglycaemia due to autosomal dominant ABCC8 mutation.
    J Pediatr Endocrinol Metab 2017 Oct 6. Epub 2017 Oct 6.
    Background: Sirolimus (mTOR inhibitor) is proven to be effective in children with congenital hyperinsulinism (CHI). Studies in animals suggest that sirolimus may have diabetogenic actions. However, its role in precipitating diabetes mellitus (DM) in children with CHI has not been reported. Read More

    Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report.
    Medicine (Baltimore) 2017 Oct;96(40):e7949
    aPediatric Endocrinologist, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia bPediatric Hepatologist Faculty of Medicine, Cairo University, Cairo, Egypt cPediatric Hepatologist Al-Hada Armed Forces Hospital, Taif, Saudi Arabia dPediatric Resident, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.
    Rationale: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy that can cause permanent brain damage. Consequently, optimal management is extremely important. Current pharmacologic and surgical treatment were available that included diazoxide and octreotides. Read More

    Neonatal Endocrine Labomas - Pitfalls and Challenges in Reporting Neonatal Hormonal Reports.
    Indian Pediatr 2017 Sep;54(9):757-762
    Division of Endocrinology, Department of Medicine, Gandhi Medical College (GMC) and Hamidia Hospital, Bhopal; and Departments of Endocrinology, *Venkateshwar Hospitals, Dwarka, #Maharaja Agrasen Hospital, and $Kalpravriksh Superspeciality Clinic, Dwarka; New Delhi; India. Correspondence to: Dr. Deep Dutta, Department of Endocrinology, Venkateshwar Hospitals, Sector 18A, Dwarka, New Delhi, India.
    This review highlights pitfalls and challenges in interpreting neonatal hormone reports. Pre-analytical errors contribute to nearly 50% of all errors. Modern chemiluminescence assay are more accurate, have lower risk of Hook's effect, but continue to have problems of assay interference. Read More

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