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    Treatment of a case of severe insulin resistance due to a PIK3R1 mutation with a sodium-glucose cotransporter-2 inhibitor.
    J Diabetes Investig 2018 Feb 24. Epub 2018 Feb 24.
    Division of Diabetes and Endocrinology and 2Division of Neurology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
    A Japanese woman in her late 30s with severe insulin resistance and bodily features including a triangular face, prominent forehead, small chin, large and low-set ears, and ocular depression was investigated. A similar phenotype was not observed in other family members with the exception of her son, suggesting that the condition was caused by a de novo mutation that was transmitted from mother to son. Exome analysis revealed the presence in the proband and her son of a c. Read More

    Thyrotoxicosis and Adrenocortical Hormone Deficiency During Immune-checkpoint Inhibitor Treatment for Malignant Melanoma.
    In Vivo 2018 Mar-Apr;32(2):345-351
    The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
    Background: Immune-checkpoint inhibitors (ICIs) are novel promising agents for the treatment of malignant tumors. However, critical endocrine immune-related adverse events (irAEs) by ICIs often occur.

    Case Report: A 63-year-old woman with advanced malignant melanoma had received anti-PD-1 antibody (nivolumab, 2 mg/kg every 3 weeks) for 8 cycles (from day 0 to day 147). Read More

    Glycaemic control and cardiovascular risk factor management in patients with diabetes with and without coronary artery disease: insights from the diabetes mellitus status in Canada survey.
    Eur Heart J Qual Care Clin Outcomes 2016 Oct;2(4):277-284
    Division of Cardiology, St. Michael's Hospital, Toronto, Canada.
    Aims: Current diabetes guidelines recommend an individualized approach to glycaemic control. There are limited data on the contemporary and comprehensive management of patients with diabetes in relation to coronary artery disease (CAD).

    Methods And Results: The Diabetes Mellitus Status in Canada (DM-SCAN) survey included 5123 patients with type 2 diabetes seen in primary care in November 2012. Read More

    PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver.
    Toxicol Sci 2018 Feb 20. Epub 2018 Feb 20.
    Interdisciplinary Graduate Program in Human Toxicology, Graduate College, The University of Iowa, Iowa City, Iowa, USA.
    3,3',4,4',5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through a wide array of non-carcinogenic effects, including metabolic syndrome, wasting, and non-alcoholic fatty-liver disease (NAFLD). Previously, we reported decreases in the transcription of several enzymes involved in gluconeogenesis, before the early onset of lipid accumulation. Hence, this study was aimed at understanding the impact of resultant decreases gluconeogenic enzymes on growth, weight and metabolism in the liver, upon extended exposure. Read More

    Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: a 52-week, open-label, phase IV study.
    Diabetes Obes Metab 2018 Feb 23. Epub 2018 Feb 23.
    Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan.
    Sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are antihyperglycaemic agents with weight-lowering effects. The efficacy and safety of the SGLT2 inhibitor canagliflozin as add-on therapy in Japanese patients with type 2 diabetes mellitus (T2DM) and inadequate glycaemic control with a GLP-1RA (≥12 weeks) were evaluated in this phase IV study. Patients received canagliflozin 100 mg once daily for 52 weeks. Read More

    Effect of exenatide QW or placebo, both added to titrated insulin glargine, in uncontrolled type 2 diabetes: the DURATION-7 randomized study.
    Diabetes Obes Metab 2018 Feb 23. Epub 2018 Feb 23.
    Dallas Diabetes Research Center at Medical City, Dallas, Texas.
    Aims: To compare the efficacy and safety of adding the glucagon-like peptide-1 receptor agonist exenatide once weekly (QW) 2 mg or placebo among patients with type 2 diabetes inadequately controlled despite titrated insulin glargine (IG) ± metformin.

    Methods: This multicentre, double-blind study randomized (1:1) patients with persistent hyperglycaemia after 8-week IG titration (glycated haemoglobin [HbA1c] 7.0-10. Read More

    Body mass index influences the plasma glucose concentration during iatrogenic hypoglycemia in people with type 2 diabetes mellitus: a cross-sectional study.
    PeerJ 2018 15;6:e4348. Epub 2018 Feb 15.
    Department of Accounting and Information Systems, National Taichung University of Science and Technology, Taichung, Taiwan.
    Background: Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant risk factors may help avert severe hypoglycemia and enhance quality of life in at-risk individuals. Read More

    The short-term economic burden of gestational diabetes mellitus in Italy.
    BMC Pregnancy Childbirth 2018 Feb 23;18(1):58. Epub 2018 Feb 23.
    CERGAS (Centre for Research on Health and Social Care Management), Bocconi University, Via Roentgen 1, 20136, Milan, Italy.
    Background: The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden of GDM from the Italian healthcare system perspective.

    Methods: A model was built over the last pregnancy trimester (i. Read More

    Anesteziol Reanimatol 2016 Jul;61(4):293-296
    Background Currently, one of the causes of high morbidity and mortality is injuries. Predict the outcome of injuries - it is an important task of the treating physician. Trauma is a stress factor so to predict the outcome, you can use markers of stress, the most accessible ofwhich is blood glucose. Read More

    [Type 2 Diabetes Diabetes in Older Adults: Example for Patient-Centered Drug Therapy].
    Dtsch Med Wochenschr 2018 Feb 22;143(4):253-261. Epub 2018 Feb 22.
    Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual. Read More

    Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa.
    Endocrinology 2018 Feb 19. Epub 2018 Feb 19.
    King's College London, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom.
    The lipid sensor GPR119 is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, PYY and GLP-1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacylglycerol (2-OG) can each activate GPR119. Here we compared mucosal responses to selective, synthetic GPR119 agonists (AR440006, AR231453) and the lipids, OEA, 2-OG and N-oleoyldopamine (OLDA) monitoring epithelial ion transport as a read-out for L-cell activity in native mouse and human gastrointestinal (GI) mucosae. Read More

    The safety of gliptins : updated data in 2018.
    Expert Opin Drug Saf 2018 Feb 22. Epub 2018 Feb 22.
    a Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine , CHU Sart Tilman, University of Liège , Liège , Belgium.
    Introduction: Dipeptidyl peptidase-4 inhibitors (DPP-4is) are generally considered as glucose-lowering agents with a safe profile in type 2 diabetes. Areas covered: An updated review of recent safety data from randomised controlled trials, observational studies, meta-analyses, pharmacovigilance reports regarding alogliptin, linagliptin, saxagliptin, sitagliptin, and vildagliptin, with a special focus on risks of hypoglycaemia, pancreatitis and pancreatic cancer, major cardiovascular events, hospitalisation for heart failure and other new safety issues, such as bone fractures and arthralgia. The safety of DPP-4i use in special populations, elderly patients, patients with renal impairment, liver disease or heart failure, will also be discussed. Read More

    Decrease of γ-aminobutyric acid and zinc ions in the islet periportal circulation stimulates glucagon secretion during hypoglycemia.
    Exp Ther Med 2018 Mar 22;15(3):2507-2511. Epub 2017 Dec 22.
    Department of Digestive Medicine, Institute of Digestive Endoscopy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
    The present study assessed the effects of γ-aminobutyric acid (GABA) from β-cells on glucose levels and glucagon secretion, and identified channels via which glucagon secretion is initiated. Anexperiment was performed containing three groups: Intrapancreatic artery infusion of GABA alone, GABA plus insulin or insulin alone in rats with diabetes. Rats infused with GABA and insulin were also subdivided in groups receiving additional infusion of K-channel activator diazoxide (DIA), K-channel blocker tolbutamide (TLB) and calcium channel blocker nifedipine (NIF). Read More

    [Prognostic value of glycemic variability in patients with decompensated chronic heart failure and diabetes mellitus].
    Kardiologiia 2017 SApr;57(S4):38-46
    Northern State Medical University.
    The review focused on the prognostic significance of hyperglycemia and glycemia variability in patients both with type 2 DM and without previously detected disorders of carbohydrate metabolism hospitalized for decompensated CHF. Results of recent studies of glycemia variability, stress-induced hypoglycemia, and their effect on prognosis for patients with decompensated CHF were analyzed. Read More

    Continuous Glucose Monitoring: a review of the evidence, opportunities for future use and ongoing challenges.
    Intern Med J 2018 Feb 21. Epub 2018 Feb 21.
    Department of Endocrinology, Austin Health, Repatriation Campus Heidelberg West, Melbourne, VIC, Australia.
    The advent of devices that can track interstitial glucose levels which are closely related to blood glucose levels on a near continuous basis has facilitated better insights into patterns of glycaemia. Continuous glucose monitoring (CGM) therefore allows for more intensive monitoring of blood glucose levels and potentially improved glycaemic control. In the context of the announcement on 1 April 2017 that the Australian Government will fund CGM monitoring for people with type 1 diabetes under the age of 21, this paper provides a review of the evidence for CGM and some of the ongoing challenges. Read More

    Factitious hypoglycemia in children and adolescents with diabetes.
    Pediatr Diabetes 2018 Feb 21. Epub 2018 Feb 21.
    Section of Pediatric Diabetes and Metabolism, DEOB, NIDDK, NIH, Bethesda, Maryland.
    Background: Factitious hypoglycemia is a condition of self-induced hypoglycemia due to surreptitious administration of insulin or oral hypoglycemic agents. In adults, it is an uncommon, but well known clinical entity observed in individuals with and without diabetes.

    Objectives: To report a case of factitious hypoglycemia highlighting diagnostic pitfalls, to identify common characteristics of children and adolescents with factitious hypoglycemia, and to examine whether the information on long-term outcome exists. Read More

    Nivolumab, a new immunomodulatory drug, a new adverse effect; adrenal crisis.
    Turk J Emerg Med 2017 Dec 20;17(4):157-159. Epub 2017 Jun 20.
    Ege University, Faculty of Medicine, Department of Emergency Medicine, Izmir, Turkey.
    Owing to the advancements in medicine, new information is obtained regarding cancer, new antineoplastic agents are developed. Frequent use of these new pharmacological agents emergency physicians to be vigilant about their side effects. We present a case of adrenal crisis in a patient with non-small cell lung cancer (NSCLC), caused by an immunomodulatory drug; nivolumab. Read More

    Clinical Benefit of Basal Insulin Analogue Treatment in Persons with Type 2 Diabetes Inadequately Controlled on Prior Insulin Therapy: A Prospective, Noninterventional, Multicenter Study.
    Diabetes Ther 2018 Feb 19. Epub 2018 Feb 19.
    Clinic for Endocrinology, Faculty of Medicine, University of Nis, Nis, Serbia.
    Introduction: Basal insulin analogues offer persons with type 2 diabetes mellitus (T2DM) adequate glycemic control combined with a favorable safety profile. BASAL-BALI-a prospective, noninterventional, multicenter disease registry-assessed the effectiveness and safety of basal insulin analogues in adult Serbians with T2DM previously inadequately controlled on other insulin types.

    Methods: The primary objective was to assess the reduction in glycated hemoglobin (HbA) from basal insulin analogue initiation to the end of a 6-month observation period. Read More

    Hypoglycemia in type 2 diabetes: understanding patients' and physicians' knowledge and experience.
    Endocrine 2018 Feb 19. Epub 2018 Feb 19.
    Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
    Purpose: The aim of the current study is to assess the patient and physician experience and knowledge of hypoglycemia in the management of type 2 diabetes (T2DM).

    Methods: T2DM patients (N = 1002) completed questionnaires on hypoglycemia experience, familiarity, and fear. Their responses were compared across various antihyperglycemic treatment regimens; specifically, (1) insulin only or insulin combined with sulfonylurea [SU] and/or metformin, (2) SU only with/without metformin, and (3) neither insulin nor SU. Read More

    Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial.
    Lancet 2018 Feb 15. Epub 2018 Feb 15.
    Research Institute Diabetes of the Diabetes Academy Mergentheim (FIDAM) (FIDAM), Bad Mergentheim, Germany; Department of Clinical Psychology and Psychotherapy, University of Bamberg, Bamberg, Germany. Electronic address:
    Background: The effectiveness of real-time continuous glucose monitoring (rtCGM) in avoidance of hypoglycaemia among high-risk individuals with type 1 diabetes treated with multiple daily insulin injections (MDI) is unknown. We aimed to ascertain whether the incidence and severity of hypoglycaemia can be reduced through use of rtCGM in these individuals.

    Methods: The HypoDE study was a 6-month, multicentre, open-label, parallel, randomised controlled trial done at 12 diabetes practices in Germany. Read More

    Patients' and caregivers' experiences of using continuous glucose monitoring to support diabetes self-management: qualitative study.
    BMC Endocr Disord 2018 Feb 20;18(1):12. Epub 2018 Feb 20.
    Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
    Background: Continuous glucose monitoring (CGM) enables users to view real-time interstitial glucose readings and provides information on the direction and rate of change of blood glucose levels. Users can also access historical data to inform treatment decisions. While the clinical and psychological benefits of CGM are well established, little is known about how individuals use CGM to inform diabetes self-management. Read More

    Establishment and validation of a prediction model for ischemic stroke risks in patients with type 2 diabetes.
    Diabetes Res Clin Pract 2018 Feb 16. Epub 2018 Feb 16.
    School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address:
    Aims: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors.

    Methods: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Read More

    Evaluating the Implementation of the EndoTool Glycemic Control Software System.
    Diabetes Spectr 2018 Feb;31(1):26-30
    Gwinnett Hospital System Pharmacy, Lawrenceville, GA.
    Purpose: The purpose of this study was to compare achievement of glycemic control on insulin drips before and after the implementation of EndoTool, a glucose management software system used in a community hospital setting.

    Methods: A retrospective chart review was performed of patients on an insulin drip who were managed before and after implementation of the EndoTool software. Fifty patients were selected for each group. Read More

    Incidence and Characteristics of Adrenal Crisis in Children Younger than 7 Years with 21-Hydroxylase Deficiency: A Nationwide Survey in Japan.
    Horm Res Paediatr 2018 Feb 16. Epub 2018 Feb 16.
    The Committee on Mass Screening, Japanese Society for Pediatric Endocrinology, Kyoto, Japan.
    Background/aims: We aimed to evaluate the incidence and characteristics of adrenal crisis in Japanese children with 21-hydroxylase deficiency (21-OHD).

    Methods: We conducted a retrospective nationwide survey for the councilors of the Japanese Society for Pediatric Endocrinology (JSPE) regarding adrenal crisis in children under 7 years with 21-OHD, admitted to hospitals from 2011 through 2016. We defined adrenal crisis as the acute impairment of general health due to glucocorticoid deficiency with at least two of symptoms, signs, or biochemical abnormalities. Read More

    The World Health Organization (WHO) versus The International Association of Diabetes and Pregnancy Study Group (IADPSG) diagnostic criteria of gestational diabetes mellitus (GDM) and their associated maternal and neonatal outcomes.
    Horm Mol Biol Clin Investig 2018 Feb 17. Epub 2018 Feb 17.
    Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, Phone: 0391455555, Fax: 0391456672.
    Background Gestational diabetes mellitus (GDM) is a common medical complication in pregnancy. The aim of this study was to compare the prevalence of GDM using the World Health Organization (WHO) criteria and the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria in our population. We further compared the incidence of adverse maternal and neonatal outcomes in women diagnosed with GDM using these criteria and determined whether the IADPSG criteria is suitable in our population. Read More

    High dose of histone deacetylase inhibitors affects insulin secretory mechanism of pancreatic beta cell line.
    Endocr Regul 2018 Jan;52(1):21-26
    1Department of Nutrition and Food Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
    Objective: Histone deacytylase inhibitors (HDACis) inhibit the deacetylation of the lysine residue of proteins, including histones, and regulate the transcription of a variety of genes. Recently, HDACis have been used clinically as anti-cancer drugs and possible anti-diabetic drugs. Even though HDACis have been proven to protect the cytokine-induced damage of pancreatic beta cells, evidence also shows that high doses of HDACis are cytotoxic. Read More

    Defining Outcomes for β-Cell Replacement Therapy in the Treatment of Diabetes: a Consensus Report on the Igls Criteria from the IPITA/EPITA Opinion Leaders Workshop.
    Transpl Int 2018 Feb 17. Epub 2018 Feb 17.
    Institute of Transplantation, The Freeman Hospital and Newcastle University, Newcastle upon Tyne, United Kingdom.
    β-cell replacement therapy, available currently as pancreas or islet transplantation, has developed without a clear definition of graft functional and clinical outcomes. The International Pancreas & Islet Transplant Association (IPITA) and European Pancreas & Islet Transplantation Association (EPITA) held a workshop to develop consensus for an IPITA/EPITA Statement on the definition of function and failure of current and future forms of β-cell replacement therapy. There was consensus that β-cell replacement therapy could be considered as a treatment for β-cell failure, regardless of etiology and without requiring undetectable C-peptide, accompanied by glycemic instability with either problematic hypoglycemia or hyperglycemia. Read More

    2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases.
    J Chin Med Assoc 2018 Feb 13. Epub 2018 Feb 13.
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
    The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). About two-thirds of death in type 2 diabetes are due to ASCVD, including 40% from coronary heart disease (CHD), 15% from heart failure (HF), and 10% from stroke. Read More

    High dose insulin for beta-blocker and calcium channel-blocker poisoning: 17years of experience from a single poison center.
    Am J Emerg Med 2018 Feb 6. Epub 2018 Feb 6.
    Minnesota Poison Control System, Department of Emergency Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN, United States.
    Background/objectives: High dose insulin (HDI) is a standard therapy for beta-blocker (BB) and calcium channel-blocker (CCB) poisoning, however human case experience is rare. Our poison center routinely recommends HDI for shock from BBs or CCBs started at 1U/kg/h and titrated to 10U/kg/h. The study objective was to describe clinical characteristics and adverse events associated with HDI. Read More

    Insulinoma: A retrospective study analyzing the differences between benign and malignant tumors.
    Pancreatology 2018 Feb 1. Epub 2018 Feb 1.
    Unidade de Endocrinologia Geral, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Brazil.
    Background/objectives: Insulinoma is a rare pancreatic tumor and, usually, a benign disease but can be a malignant one and, sometimes, a highly aggressive disease. The aim of this study was to determine differences between benign and malignant tumors.

    Methods: Retrospective study of 103 patients with insulinoma treated in a tertiary center. Read More

    Effects of Canagliflozin Versus Glimepiride on Adipokines and Inflammatory Biomarkers in Type 2 Diabetes.
    Metabolism 2018 Feb 13. Epub 2018 Feb 13.
    Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA. Electronic address:
    Objective: Type 2 diabetes and obesity are pro-inflammatory states associated with increased risk of cardiovascular disease. Canagliflozin, an SGLT2 inhibitor, demonstrated superiority in lowering HbA1c versus glimepiride with less hypoglycemia and greater weight reduction via loss of fat mass in a 52-week trial of type 2 diabetes patients. This post hoc, exploratory analysis assessed the effects of canagliflozin versus glimepiride on select adipokines, inflammatory biomarkers, and chemokines. Read More

    Sodium-glucose co-transporter 2 (SGLT2) inhibitors as add-on therapy to insulin for type 1 diabetes mellitus: Systematic review and meta-analysis of randomized controlled trials.
    Diabetes Obes Metab 2018 Feb 16. Epub 2018 Feb 16.
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Japan.
    New treatments for type 1 diabetes are an unmet need. We investigated the efficacy and safety of adding SGLT-2is to insulin for type 1 diabetes by meta-analysis of prospective randomized, placebo-controlled trials. Searching electronic databases up to October 2017 identified 1361 studies, among which 14 were investigated (N=4,591). Read More

    Insulin degludec/insulin aspart lowers fasting plasma glucose and rates of confirmed and nocturnal hypoglycaemia independent of baseline HbAlevels, disease duration or BMI: A pooled meta-analysis of phase 3 studies in patients with type 2 diabetes.
    Diabetes Obes Metab 2018 Feb 16. Epub 2018 Feb 16.
    Endocrine and Metabolic Consultants, Rockville, MD, USA.
    Aims: Previous studies demonstrated the co-formulation of insulin degludec (IDeg)/insulin aspart (IAsp) 'IDegAsp' offers lower rates of hypoglycaemia with smaller changes in weight compared with basal-bolus (IDeg once daily [OD] + IAsp [2-4 injections]) and premix insulin (BIAsp 30 twice daily [BID]) comparators. This study aimed to investigate whether the benefits of IDegAsp, given twice daily, extend across a wide spectrum of patients with diabetes.

    Materials And Methods: This was a post hoc pooled analysis of five phase 3 randomised, 26-week, open-label, BID, treat-to-target trials comparing IDegAsp BID (n = 1111) with one of two 'comparators' - BIAsp 30 BID (n = 561) or IDeg OD + IAsp (n = 136). Read More

    Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus.
    J Diabetes Sci Technol 2018 Feb 1:1932296818758105. Epub 2018 Feb 1.
    2 Hospital Universitario San Ignacio, Bogotá, Colombia.
    Introduction: Recent publications frequently introduce new indexes to measure glycemic variability (GV), quality of glycemic control, or glycemic risk; however, there is a lack of evidence supporting the use of one particular parameter, especially in clinical practice.

    Methods: A cohort of type 2 diabetes mellitus (T2DM) patients in ambulatory care were followed using continuous glucose monitoring sensors (CGM). Mean glucose (MG), standard deviation, coefficient of variation (CV), interquartile range, CONGA1, 2, and 4, MAGE, M value, J index, high blood glucose index, and low blood glucose index (LBGI) were estimated. Read More

    Diabetic Kidney Disease: Is There a Role for Glycemic Variability?
    Curr Diab Rep 2018 Feb 15;18(3):13. Epub 2018 Feb 15.
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, 4245 Roosevelt Way NE, Box 354691, Seattle, WA, 98105, USA.
    Purpose Of Review: Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. Read More

    Effectiveness of a multi-component quality improvement intervention on rates of hyperglycaemia.
    BMJ Open Qual 2017 26;6(2):e000059. Epub 2017 Oct 26.
    Department of Medicine, Virginia Mason Medical Center, Seattle, Washington, USA.
    Purpose: To evaluate the effectiveness of a multifaceted, hospital-wide glycaemic control quality improvement programme.

    Methods: The quality improvement intervention comprised three components, derived through root cause analysis: standardising and simplifying care (including evidence-based order sets), increasing visibility (through provider access to clinical data and direct feedback) and educational outreach (directed at the entire institution). Effectiveness was determined at a single urban acute care hospital through time-series analysis with statistical process control charts. Read More

    Roux en Y gastric bypass hypoglycemia resolves with gastric feeding or reversal: Confirming a non-pancreatic etiology.
    Mol Metab 2018 Jan 31. Epub 2018 Jan 31.
    Division of General Surgery, Department of Surgery, 600 Highland Avenue, University of Wisconsin, Madison, WI, 53705, USA; Division of Bariatric and Gastrointestinal Surgery, Department of Surgery, Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA, 23298, USA. Electronic address:
    Objective: Postprandial hypoglycemia is an infrequent but disabling complication of Roux-en-Y gastric bypass (RYGB) surgery. Controversy still exists as to whether the postprandial hyperinsulinemia observed is due to inherent changes in pancreatic β-cell mass or function or to reversible alterations caused by RYGB anatomy. We aimed to determine if gastric feeding or reversal of RYGB would normalize postprandial glucose and hormone excursions in patients with symptomatic hypoglycemia. Read More

    Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label period.
    Curr Med Res Opin 2018 Feb 15:1-35. Epub 2018 Feb 15.
    e Taisho Pharmaceutical Co., Ltd. , 3-24-1 Takada, Toshima-ku , Tokyo 170-8633 , Japan.
    Objective: To evaluate the efficacy and safety of luseogliflozin in Japanese patients with type 2 diabetes (T2D) inadequately controlled with insulin monotherapy.

    Methods: This 52-week multicenter study entailed a 16-week, double-blind period followed by a 36-week, open-label period. Patients were randomized to receive either luseogliflozin 2. Read More

    Mismatch between GLUTs and glucose levels causes neuronal damage during glucose fluctuations.
    Med Hypotheses 2018 Mar 2;112:37-39. Epub 2018 Feb 2.
    Department of Critical Care Medicine, West China Hospital, Sichuan University, China.
    Abnormal glucose levels damage the central nervous system, especially in case of rapid fluctuations. Even a single episode of glucose reperfusion can result in overt impairment of neurons. Oxidative stress plays an important role in this process, sharing properties with the pathophysiologic changes of glucose neurotoxicity. Read More

    A social media intervention to improve hypoglycaemia management at a multi-centre hospital: A quality improvement pilot for clinical nurses.
    Contemp Nurse 2018 Feb 15:1-17. Epub 2018 Feb 15.
    d Registered Nurse, Bachelor of Science Nursing, Master of Education, Certified Diabetes Educator , 1967 Riverside Drive Box 215, Ottawa , Ontario , K1H 7W9 , Canada.
    Background: Hypoglycaemia is associated with increased mortality, length of stay, readmission and adverse events. Nursing management of hypoglycaemia is a challenge, despite established best practice guidelines. Social media is an effective tool for sharing information, and had potential to overcome barriers to clinical education at a multi-centre hospital. Read More

    Accuracy of flash glucose monitoring and continuous glucose monitoring technologies: Implications for clinical practice.
    Diab Vasc Dis Res 2018 Feb 1:1479164118756240. Epub 2018 Feb 1.
    3 Derby Teaching Hospitals, Derby, UK.
    Continuous glucose monitoring and flash glucose monitoring technologies measure glucose in the interstitial fluid and are increasingly used in diabetes care. Their accuracy, key to effective glycaemic management, is usually measured using the mean absolute relative difference of the interstitial fluid sensor compared to reference blood glucose readings. However, mean absolute relative difference is not standardised and has limitations. Read More

    Safety and tolerability of dapagliflozin, saxagliptin and metformin in combination: post hoc analysis of concomitant add-on versus sequential add-on to metformin and of triple versus dual therapy with metformin.
    Diabetes Obes Metab 2018 Feb 15. Epub 2018 Feb 15.
    Clinical and Experimental Endocrinology, University of Leuven (KU Leuven), Leuven, Belgium.
    The safety of triple oral therapy with dapagliflozin plus saxagliptin plus metformin, versus dual therapy with dapagliflozin or saxagliptin plus metformin, was compared in a post hoc analysis of three randomized trials of sequential or concomitant add-on of dapagliflozin and saxagliptin to metformin. In the concomitant add-on trial, patients with type 2 diabetes on stable metformin received dapagliflozin 10 mg/day plus saxagliptin 5 mg/day. In sequential add-on trials, patients on metformin plus either saxagliptin 5 mg/day or dapagliflozin 10 mg/day received add-on dapagliflozin 10 mg/day or saxagliptin 5 mg/day, respectively. Read More

    Relationship between Blood Glucose Fluctuation and Brain Damage in the Hypoglycemia Neonates.
    Am J Perinatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, China.
    Objective:  To investigate the relationship between blood glucose fluctuation and brain damage in the hypoglycemia neonates.

    Study Design:  A retrospective study including all neonates hospitalized due to hypoglycemia from September 2013 to August 2016 was performed. All the 58 hypoglycemia infants were divided into two groups-the brain-damaged group and the nonbrain-damaged group, according to head magnetic resonance imaging and/or amplitude-integrated electroencephalogram. Read More

    Neuroimaging of first seizure in the adult emergency patients.
    Acta Neurol Belg 2018 Feb 13. Epub 2018 Feb 13.
    Department of Radiology, Uludag University Faculty of Medicine, Bursa, Turkey.
    The aim is to establish the role of head computed tomography (CT) and magnetic resonance imaging (MRI) in adults presenting to the emergency department (ED) with first-time seizure (FS) and to analyze the potential predictor variables for the adverse imaging outcome. We retrospectively reviewed the medical records of all adults who underwent cranial CT or MRI between January 1, 2011, and December 1, 2016, to an academic ED for FS. Patients were excluded if were under 18 years of age, had known recent intracranial pathology, known brain tumor or having a history of trauma. Read More

    Regulation of KChannel Trafficking in Pancreatic β Cells by Protein Histidine Phosphorylation.
    Diabetes 2018 Feb 12. Epub 2018 Feb 12.
    Division of Nephrology,
    Protein histidine phosphatase 1 (PHPT-1) is an evolutionarily conserved 14 kDa protein that dephosphorylates phosphohistidine.mice were generated to gain insight into the role of PHPT-1 and histidine phosphorylation/dephosphorylation in mammalian biology.mice exhibited neonatal hyperinsulinemic hypoglycemia due to impaired trafficking of Kchannels to the plasma membrane in pancreatic β cells in response to low glucose and leptin and resembled patients with congenital hyperinsulinism (CHI). Read More

    Measurement of psychological adjustment to diabetes with the diabetes acceptance scale.
    J Diabetes Complications 2018 Jan 31. Epub 2018 Jan 31.
    Research Institute of the Diabetes Academy Mergentheim (FIDAM), Johann-Hammer-Str. 24, 97980 Bad Mergentheim, Germany; Diabetes Center Mergentheim (DZM), Theodor-Klotzbuecher-Str. 12, 97980 Bad Mergentheim, Germany; German Center for Diabetes Research (DZD), Ingolstaedter Landstr. 1, 85764 Muenchen, Neuherberg, Germany; Otto-Friedrich-University of Bamberg, Department for Psychology, Markusplatz 3, 96047 Bamberg, Germany.
    Aims: To develop a psychometric measure of diabetes acceptance.

    Methods: An item pool was developed and pilot-tested using a sample of 220 people with diabetes; item selection resulted in the 20-item 'Diabetes Acceptance Scale (DAS)'. 606 people with diabetes were then cross-sectionally assessed with the DAS to evaluate its reliability, validity and clinical utility; concurrent measurements included diabetes-related coping (FQCI), diabetes distress (PAID-5), depressive symptoms (PHQ-9), quality of life (EQ-5D), self-management (DSMQ), glycaemic control (HbA) and complications. Read More

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