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    Prognostic Impact of Combined Dysglycemia and Hypoxic Liver Injury on Admission in Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention (from the INTERSTELLAR Cohort).
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Sejong General Hospital, Bucheon, Republic of Korea. Electronic address:
    Dysglycemia on admission is known to predict the prognosis of ST-segment elevation myocardial infarction (STEMI). Recently, hypoxic liver injury (HLI) has been proposed as a novel prognosticator for STEMI. We evaluated the prognostic impact of combined dysglycemia and HLI at the time of presentation in patients with STEMI who underwent primary percutaneous coronary intervention. Read More

    Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes.
    Diabetes Care 2017 Feb 17. Epub 2017 Feb 17.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, U.K.
    Objective: Hypoglycemia may exert proarrhythmogenic effects on the heart via sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac dysrhythmias are linked to the "dead-in-bed syndrome," a rare, but devastating, condition. We examined the effect of nocturnal and daytime clinical hypoglycemia on electrocardiogram (ECG) in young people with type 1 diabetes. Read More

    [Zinc phosphide poisoning in pediatric patients from a Toxicology Center at Mexico City].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S44-S52
    Departamento Clínico de Toxicología, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Zinc phosphide is a chemical compound that is frequently used as a rodenticide; it is a highly toxic product that is widely used, among other spaces, at home. Given that it is a highly commercialized pesticide and that there is no antidote, it is mandatory to establish favorably the clinical manifestations of the intoxication. The aim was to describe the epidemiological and clinical profile of children intoxicated with zinc phosphide attended in a toxicological center of a tertiary referral hospital. Read More

    Timothy syndrome 1 genotype without syndactyly and major extracardiac manifestations.
    Am J Med Genet A 2017 Mar;173(3):784-789
    Institute of Biophysics, Biological Research Centre, Szeged, Hungary.
    Timothy syndrome 1 (TS1) is a rare genetic disorder characterized by multisystem abnormalities including QT prolongation, congenital heart defects, facial dysmorphism, episodic hypoglycemia, and neurological symptoms. A morphological hallmark of TS1 is syndactyly, present in all cases. TS1 is caused by the canonical p. Read More

    Short-acting GLP-1 receptor agonists as add-on to insulin therapy in type 1 diabetes - a review.
    Diabetes Obes Metab 2017 Feb 17. Epub 2017 Feb 17.
    Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    A large proportion of patients with type 1 diabetes do not reach their glycemic target of glycated hemoglobin (HbA1c) <7.0% (53 mmol/mol) and, furthermore, an increasing number of patients with type 1 diabetes suffer from overweight and obesity. Treatment of type 1 diabetes is based on insulin therapy with well-described and unfortunate adverse effects such as hypoglycemia and increased body weight. Read More

    Preclinical characterisation of 55P0251, a novel compound that amplifies glucose stimulated insulin secretion and counteracts hyperglycaemia in rodents.
    Diabetes Obes Metab 2017 Feb 17. Epub 2017 Feb 17.
    Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
    Aims: 55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic pharmacological attributes and initial progress in unmasking the mode of action.

    Materials And Methods: Pharmacokinetic properties of 55P0251 were portrayed in several species. Read More

    Delays in treatment intensification with oral antidiabetic drugs and risk of microvascular and macrovascular events in patients with poor glycemic control: An individual patient simulation study.
    Diabetes Obes Metab 2017 Feb 17. Epub 2017 Feb 17.
    AstraZeneca, One MedImmune Way, Gaithersburg, MD, USA, 20878.
    Aims: Despite guideline recommendations, many patients with type 2 diabetes on oral antidiabetic drugs (OADs) whose HbA1c results remain above target do not experience timely treatment intensification. This study uses the Archimedes Model® to estimate the consequences of delays in OAD treatment intensification on glycemic control and long-term outcomes at 5 and 20 years.

    Materials And Methods: Using real world data, we modeled a cohort of hypothetical patients with HbA1c ≥8%, on metformin, with no history of insulin use. Read More

    The Role of the Pharmacist in Managing Type 2 Diabetes with Glucagon-Like Peptide-1 Receptor Agonists as Add-On Therapy.
    Adv Ther 2017 Feb 16. Epub 2017 Feb 16.
    Director of Clinical Services, Plaza Pharmacy and Wellness Center, Gainesville, TX, USA.
    The prevalence and associated clinical burden of type 2 diabetes (T2D) is increasing in the USA and other countries. As a consequence, the role of the pharmacist in managing T2D is expanding, and it is becoming increasingly important for pharmacists to have a complete understanding of the disease course and treatment options. Pharmacists have a key role in the use of injectable therapies, including incretin-based treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs). Read More

    Cost-effectiveness of Insulin Degludec Versus Insulin Glargine in Adults with Type 1 and Type 2 Diabetes Mellitus.
    Diabetes Ther 2017 Feb 16. Epub 2017 Feb 16.
    Novo Nordisk A/S, Soborg, Copenhagen, Denmark.
    Introduction: To estimate the cost-effectiveness of insulin degludec (IDeg) versus insulin glargine U100 (IGlar U100) and new-to-market basal insulin analogues in patients with diabetes in order to aid decision-making in a complex basal insulin market.

    Methods: A simple, short-term model was used to evaluate the costs and effects of treatment with IDeg versus IGlar U100 over a 12-month period in patients with type 1 (T1DM) and type 2 diabetes (T2DM) from the perspective of the UK National Health Service. New-to-market basal insulin analogues were evaluated in scenario analyses. Read More

    Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report.
    Innov Clin Neurosci 2016 Nov-Dec;13(11-12):25-27. Epub 2016 Dec 1.
    All from the Department of Psychiatry at the Postgraduate Institute of Medical Education and Research in Chandigarh, India.
    Although psychiatric manifestations in the form of delirium, confusional states, and psychosis have been commonly reported in relation to hypoglycemia, association of hyperglycemia with psychiatric manifestations has been less commonly reported. In this case report, we present the case of a 36-year-old woman suffering from Type 1 diabetes mellitus who developed recurrent episodes of psychosis following poor adherence to her insulin therapy, leading to significantly high levels of blood glucose. Adequate control of blood glucose levels by improving the adherence with insulin led to lack of recurrence of psychosis. Read More

    REPLACE-BG: A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Well-Controlled Adults With Type 1 Diabetes.
    Diabetes Care 2017 Feb 16. Epub 2017 Feb 16.
    Jaeb Center for Health Research, Tampa, FL.
    Objective: To determine whether the use of continuous glucose monitoring (CGM) without confirmatory blood glucose monitoring (BGM) measurements is as safe and effective as using CGM adjunctive to BGM in well-controlled adults with type 1 diabetes (T1D).

    Research Design And Methods: A randomized noninferiority clinical trial was conducted at 14 sites in the T1D Exchange Clinic Network. Participants were ≥18 years of age (mean 44 ± 14 years), had T1D for ≥1 year (mean duration 24 ± 12 years), used an insulin pump, and had an HbA1c ≤9. Read More

    A Systematic Review and Meta-Analysis of Executive Function Performance in Type 1 Diabetes Mellitus.
    Psychosom Med 2017 Feb 16. Epub 2017 Feb 16.
    1Queensland University of Technology School of Psychology and Counselling; Institute of Health and Biomedical Innovation.
    Objective: To examine the current evidence for executive function (EF) performance differences between groups with Type 1 diabetes mellitus (T1DM) and non-diabetic control groups during adolescence and early adulthood, and to explore the relationships between EF and diabetes-related risk factors.

    Methods: A systematic review of the literature examining EF performance in groups with T1DM was conducted according to the PRISMA guidelines. Electronic database searches for published and unpublished literature yielded a final set of 26 articles after application of inclusion and exclusion criteria. Read More

    Evaluation of Subcutaneous Glucose Monitoring Systems under Routine Environmental Conditions in Patients with Type 1 Diabetes.
    Diabetes Obes Metab 2017 Feb 16. Epub 2017 Feb 16.
    Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
    Continuous and flash glucose monitoring (GM) systems have been established in diabetes care. We compared sensor performance of three commercially available GM systems. 12 patients with type 1 diabetes were included in a single-centre, open-label study where sensor performance of Abbott FreeStyle libre (Abbott), Dexcom G4 Platinum (Dexcom) and Medtronic MiniMed 640G (Medtronic) over 12 hours was compared during mimicked real-life conditions (meals, exercise, hypo- and hyperglycaemia). Read More

    The renal effects of SGLT2 inhibitors and a mini-review of the literature.
    Ther Adv Endocrinol Metab 2016 Dec 11;7(5-6):212-228. Epub 2016 Nov 11.
    Iatriko Paleou Falirou Medical Center, 36 Areos Street, 17562, Paleo Faliro, Athens, Greece.
    Sodium-glucose linked transporter 2 (SGLT2) inhibitors are a new and promising class of antidiabetic agents which target renal tubular glucose reabsorption. Their action is based on the blockage of SGLT2 sodium-glucose cotransporters that are located at the luminal membrane of tubular cells of the proximal convoluted tubule, inducing glucosuria. It has been proven that they significantly reduce glycated hemoglobin (HbA1c), along with fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus (T2DM). Read More

    Paroxysmal Hypertension Induced by an Insulinoma.
    Intern Med 2017 15;56(4):413-417. Epub 2017 Feb 15.
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
    Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. Read More

    [Hypoglycemic Hemiplegia].
    Brain Nerve 2017 Feb;69(2):101-110
    Department of Neurology, Yokohama Brain and Spine Center.
    Hypoglycemia may cause acute hemiplegia. The most common diffusion-weighted MR imaging finding in patients with hypoglycemic hemiplegia is the hyperintense lesion involving the internal capsule, mimicking acute ischemic stroke. Thus, in patients with acute onset hemiplegia, it is important to differentiate hypoglycemia on arrival by immediate blood glucose measurement. Read More

    Hypoglycemia and Glucocorticoid-free Immunosuppression are Related With Low Dehydroepiandrosterone Sulfate Level.
    Endocr Metab Immune Disord Drug Targets 2017 Feb 13. Epub 2017 Feb 13.
    Institute for Clinical and Experimental Medicine - Diabetes Centre Prague 4, Czech Republic.
    Background: Low dehydroepiandrosterone sulfate (DHEAS) levels and a high cortisol/DHEAS ratio are associated with higher mortality in elderly, dialyzed, and immunocompromised patients. The role of these hormones in patients with hypoglycemia unawareness (hypo) or in pancreas or islet recipients treated by glucocorticoid-free immunosuppressive regimen (IS) has not been studied.

    Objective: The aim of this study was to determine the effects of IS and of recurrent hypoglycemia on DHEAS and adrenocorticotropic hormone (ACTH) levels in patients with type-1 diabetes (T1DM). Read More

    Add on Exenatide Treatment is Beneficial in Poorly Controlled Obese Type 2 Diabetics under Intensive Insulin Regimens.
    Exp Clin Endocrinol Diabetes 2017 Feb 15. Epub 2017 Feb 15.
    Gulhane Military Medical Academy, Department of Endocrinology and Metabolism, School of Medicine, Ankara/TURKEY.
    Background: Intensive insulin treatment is bothersome in obese patients with type 2 diabetes mellitus. High insulin dosages further increase weight gain and the risk of hypoglycemia. Glucagon like peptide-1 receptor agonists decrease the insulin need, cause weight loss and reduce the risk of hypoglycemia. Read More

    The duration of intrapartum maternal hyperglycaemia predicts neonatal hypoglycaemia in women with pre-existing diabetes.
    Diabet Med 2017 Feb 15. Epub 2017 Feb 15.
    Departments of Diabetes John Hunter Hospital.
    Aim: There is a high incidence of neonatal hypoglycaemia in neonates born to mothers with pre-existing diabetes. This often necessitates admission to the neonatal intensive care. Guidelines suggest maintaining intrapartum blood glucose levels (BGLs) of 4-7 mmol/l in women with diabetes to reduce the risk of neonatal hypoglycaemia. Read More

    A Retrospective Analysis of Adverse Events in Hyperbaric Oxygen Therapy (2012-2015): Lessons Learned From 1.5 Million Treatments.
    Adv Skin Wound Care 2017 Mar;30(3):125-129
    Hanna Jokinen-Gordon, PhD, is Director of Research and Informatics; Richard C. Barry, MS, CHT-A, is Vice President of Facility and Hyperbaric Services; Beckie Watson, BSH, is Vice President of Quality, and D. Scott Covington, MD, FACS, CHWS, is Chief Medical Officer, Healogics, Inc, Jacksonville, Florida. The authors have disclosed they are employees of Healogics, Inc, a healthcare management company and provider of hyperbaric oxygen therapy.
    Objective: To describe the distribution and occurrence of adverse events recorded during hyperbaric oxygen (HBO) therapy from 2012 to 2015. In this analysis, events are defined as otic/sinus barotrauma, confinement anxiety, hypoglycemia, oxygen toxicity, pneumothorax, seizure, and shortness of breath.

    Data And Analysis: The data for the analysis were drawn from a proprietary electronic health data system that contained information on 1,529,859 hyperbaric treatments administered during 53,371 treatment courses from 2012 to 2015 in outpatient wound care centers across the United States managed by Healogics, Inc, Jacksonville, Florida. Read More

    Auxiliendo, Primum Non Nocere: A Preliminary View of the DEVOTE Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Type 2 Diabetes.
    Diabetes Ther 2017 Feb 14. Epub 2017 Feb 14.
    Department of Endocrinology, Bharti Hospital, Karnal, India.
    A demonstration of cardiovascular safety is mandatory for all newly developed glucose-lowering agents, including insulin analogues. The vascular benefit of insulin is evident from the Diabetes Control and Complication Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS), and the cardiovascular safety of insulin glargine has been demonstrated in individuals with newly diagnosed diabetes or prediabetes in the ORIGIN trial (Outcome Reduction with an Initial Glargine Intervention). The top-line results of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs. Read More

    Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
    ACS Med Chem Lett 2017 Feb 23;8(2):221-226. Epub 2017 Jan 23.
    Departments of Discovery Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, In Vivo Pharmacology, and In Vitro Pharmacology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
    GPR40 is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial agonists elicits insulin secretion only in the presence of elevated blood glucose levels, minimizing the risk of hypoglycemia. GPR40 agoPAMs have shown superior efficacy to partial agonists as assessed in a glucose tolerability test (GTT). Read More

    The Impact of Different Plasma Glucose Levels on Heart Rate in Experimental Rats With Acute Myocardial Infarction.
    Cardiol Res 2016 Aug 5;7(4):146-151. Epub 2016 Sep 5.
    Beijing Anzhen Hospital Affiliated to Capital Medical University; Beijing Institute of Heart, Lung and Blood Vessel Disease; The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing, China.
    Background: The aim of the study was to evaluate the impact of different plasma glucose levels on heart rate (HR) in experimental rats with acute myocardial infarction (AMI).

    Methods: One hundred and twenty-one male Wistar rats were randomly divided into AMI group (n = 70) and sham-operation group (n = 51). Both groups had low, normal and high glucose levels, respectively. Read More

    Safety, tolerability, and efficacy of lixisenatide as monotherapy in Japanese patients with type 2 diabetes mellitus: An open-label, multicenter study.
    J Diabetes Investig 2017 Feb 13. Epub 2017 Feb 13.
    Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
    Aim/introduction: To assess overall safety of lixisenatide monotherapy in Japanese patients with type 2 diabetes mellitus.

    Materials And Methods: Patients with type 2 diabetes mellitus, previously treated with ≤1 oral antidiabetic drugs, were enrolled in an uncontrolled, open-label, single-arm study over 24 and 52 weeks. Any oral antidiabetic drug treatment was stopped at the start of the 6-week run-in period. Read More

    Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.
    J Physiol 2017 Feb 14. Epub 2017 Feb 14.
    Perinatal Research Center, University of Colorado School of Medicine, Aurora, Colorado, USA.
    Placental insufficiency and intrauterine growth restriction (IUGR) of the fetus affects approximately 8% of all pregnancies and is associated with short- and long-term disturbances in metabolism. In pregnant sheep, experimental models with a small, defective placenta that restricts delivery of nutrients and oxygen to the fetus result in IUGR. Low blood oxygen concentrations increase fetal plasma catecholamine concentrations, which lower fetal insulin concentrations. Read More

    Standards of admission capillary blood glucose levels in cesarean born neonates.
    World J Pediatr 2017 Feb 14. Epub 2017 Feb 14.
    Department of Neonatology, Ruth Rappaport Children's Hospital, Haifa Israel, Rambam Health Care Campus, Haifa, Israel.
    Background: Neonatal hypoglycemia (NH) and cutoffs remain undefined. Our center screens all cesareandelivered (CD) neonates for NH. We sought to define standards of admission capillary blood glucose levels (ACBGLs) in CD neonates who were at the lowest risk for hypoglycemia. Read More

    Rational design and synthesis of some PPAR-γ agonists: Substituted benzylideneamino-benzylidene-thiazolidine-2,4-diones.
    Comput Biol Chem 2017 Feb 7;67:260-265. Epub 2017 Feb 7.
    Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.
    The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most successful target for management of diabetes mellitus. The present work endeavors rational designing of some novel PPAR-γ agonists bearing benzylideneamino-benzylidene-thiazolidine-2,4-dione scaffold. The research involved virtual screening of 37 different molecules by molecular docking studies performed by Molecular Design Suite (MDS) into the ligand binding domain of PPAR-γ receptor to explore the binding affinity and conformations of the molecules. Read More

    Management of hospitalized type 2 diabetes mellitus patients.
    J Transl Int Med 2016 Dec 30;4(4):155-161. Epub 2016 Dec 30.
    Section of Endocrinology, University Hospital Infanta Leonor, School of Medicine, Complutense University, Madrid 28031, Spain.
    Both hyperglycemia and hypoglycemia in hospitalized patients are associated with adverse outcomes including increased rates of infection, longer hospital length of stay, and even death. Clinical trials in patients with type 2 diabetes mellitus proved that by improving glycemic control, we can reduce all of them. Insulin is the preferred treatment for glycemic control in most cases, but alternative treatment options that can normalize blood glucose levels without hypoglycemia are being sought. Read More

    Prevention of diabetes in Bangladeshis in East London: experiences and views of young people.
    J Transl Int Med 2016 Jun 7;4(2):88-93. Epub 2016 Jul 7.
    Healthwatch Tower Hamlets, Mile End Hospital, Bancroft Road, London E1 4DG, UK.
    Background And Objectives: Type 2 diabetes is common amongst Bangladeshis, and prevention strategies are needed. Little is known about the views of younger people concerning diabetes prevention and the risk factors. We aimed to explore the experience and views on the prevention of diabetes amongst young Bangladeshis in Tower Hamlets. Read More

    DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.
    Cell Metab 2017 Jan 30. Epub 2017 Jan 30.
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:
    Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined. Here we show reduced expression of activated dynamin-related protein (pDRP1), a mitochondrial fission regulator, in POMC neurons of fed mice. Read More

    Attitude, complications, ability of fasting and glycemic control in fasting Ramadan by children and adolescents with type 1 diabetes mellitus.
    Diabetes Res Clin Pract 2017 Feb 1;126:10-15. Epub 2017 Feb 1.
    Institute of Public Health, Emirates University, Al Ain, United Arab Emirates.
    Objectives: Sick individuals and children are exempted from fasting Ramadan. Fasting by type 1 diabetes patients might predispose to acute complications. There are no guidelines on fasting safety or its impact on diabetes control in children and adolescents. Read More

    Lixisenatide Therapy in Older Patients With Type 2 Diabetes Inadequately Controlled on Their Current Antidiabetic Treatment: The GetGoal-O Randomized Trial.
    Diabetes Care 2017 Feb 10. Epub 2017 Feb 10.
    Townhead Surgery, Irvine, U.K.
    Objective: To evaluate the efficacy and safety of lixisenatide versus placebo on glycemic control in older patients with type 2 diabetes uncontrolled on their current antidiabetic treatment.

    Research Design And Methods: In this phase III, double-blind, randomized, placebo-controlled, two-arm, parallel-group, multicenter trial, patients aged ≥70 years were randomized to receive once-daily lixisenatide 20 μg or placebo before breakfast concomitantly with their existing antidiabetic therapy (including insulin) for 24 weeks. Patients at risk for malnutrition or with moderate to severe cognitive impairment were excluded. Read More

    Complications During Ketogenic Diet Initiation: Prevalence, Treatment, and Influence on Seizure Outcomes.
    Pediatr Neurol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland; Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:
    Background: Many centers still admit children for several days to start the ketogenic diet. The exact incidence of adverse effects during the admission and their potential later impact on seizure reduction has not been widely studied.

    Methods: We performed a retrospective study of children with intractable epilepsy electively admitted for ketogenic diet initiation at our institution from 2011 to 2016. Read More

    A Review of the Clinical Efficacy and Safety of Insulin Degludec and Glargine 300 U/mL in the Treatment of Diabetes Mellitus.
    Clin Ther 2017 Feb 7. Epub 2017 Feb 7.
    Section of Endocrinology and Metabolism, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
    Purpose: The treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using insulin is not ideal at this time. Despite advances made with basal insulin analogues, many individuals achieve less than optimal glycemic control or are at risk for hypoglycemia. Currently available basal insulin analogues do not deliver steady, peakless, continuous insulin for >24 hours and are associated with adverse events, including hypoglycemia. Read More

    Lack of Health-Related Quality of Life and Patient-Centred Outcome Measures in Randomized Controlled Trials Conducted for Diabetes Pharmacotherapy: SGLT-2 Receptor Inhibitors as An Example.
    J Popul Ther Clin Pharmacol 2017 Jan 9;24(1):e1-e14. Epub 2017 Jan 9.
    Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario.
    Background: Use of SGLT-2 receptor inhibitors has been associated with weight loss and a low rate of hypoglycemia in comparison to sulfonylureas. These factors may improve health-related quality of life for patients with diabetes.

    Objectives: To systematically explore randomized controlled trials (RCTs) involving SGLT-2 receptor inhibitors that reported health-related quality of life changes. Read More

    The haemoglobin glycation index as predictor of diabetes-related complications in the AleCardio trial.
    Eur J Prev Cardiol 2017 Jan 1:2047487317692664. Epub 2017 Jan 1.
    1 Department of Endocrinology, Academic Medical Centre, University of Amsterdam, The Netherlands.
    The haemoglobin glycation index (HGI) quantifies the interindividual variation in the propensity for glycation and is a predictor of diabetes complications and adverse effects of intensive glucose lowering. We investigated the relevance of HGI as independent predictor of complications by using data of the AleCardio trial. The AleCardio trial randomized 7226 type 2 diabetes patients with an acute coronary syndrome to aleglitazar or placebo. Read More

    Practically prepared? Pre-intern student views following an education package.
    Adv Med Educ Pract 2017 27;8:111-120. Epub 2017 Jan 27.
    Central Clinical School, Sydney Medical School, The University of Sydney, NSW, Australia.
    Background: Graduating medical students enter their internship with varied levels of practical experience in procedural skills. To address this problem, many medical schools have introduced intensive skill training courses immediately prior to graduation. This study examines the impact of a pre-intern (PrInt) education package, consisting of a short intensive course, followed by a one-month clinical attachment. Read More

    Effect of basal insulin dosage on blood glucose concentration in ambulatory surgery patients with type 2 diabetes.
    J Clin Anesth 2017 Feb 5;36:184-188. Epub 2016 Dec 5.
    Department of Medicine, Emory University School of Medicine and Emory Healthcare, 1364 Clifton Rd, Atlanta, GA 30322, USA.
    Study Objective: Among patients with type 2 diabetes treated with insulin, perioperative hyperglycemia and hypoglycemia may cause undesirable symptoms, surgery delay or cancellation, or unexpected hospitalization. Our objective was to compare preoperative glargine dosing regimens on perioperative glycemic control in patients undergoing ambulatory surgery.

    Design: Observational study. Read More

    A 66-Year-Old Woman With Sudden Onset of Disseminated Intravascular Coagulation, Lactic Acidosis, and Hypoglycemia.
    Chest 2017 Feb;151(2):e41-e44
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.
    A 66-year-old woman presented to an urgent care clinic for 2 to 3 weeks of general malaise, nausea/vomiting, night sweats, and dyspnea. On examination, she was tachycardic, and her laboratory evaluation was normal except for a lactate level of 4.4 mmol/L and platelet count of 118 × 10(9)/L. Read More

    Hypoglycemia manifestations and recurrent events: lessons from the SAVOR-TIMI 53 outcome study.
    Diabetes Obes Metab 2017 Feb 9. Epub 2017 Feb 9.
    The Diabetes Unit, Hadassah University Hospital, Jerusalem, Israel.
    Hypoglycemia is a well-known risk associated with the use of sulfonylureas and insulin, often limiting achievement of glycemic goals. Recognizing the precipitants and recurrence patterns of hypoglycemic events, particularly major events, is therefore clinically important. The SAVOR-TIMI-53 trial was a cardiovascular outcome study of 16,492 patients allocated to saxagliptin vs. Read More

    mRNA destabilization improves glycemic responsiveness of transcriptionally regulated hepatic insulin gene therapy in vitro and in vivo.
    J Gene Med 2017 Feb 8. Epub 2017 Feb 8.
    Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.
    Background: Hepatic insulin gene therapy (HIGT) employing a glucose and insulin sensitive promoter to direct insulin transcription can lower blood sugars within 2 hours of an intra-peritoneal glucose challenge. However, post-challenge blood sugars frequently decline to below baseline. We hypothesize that this "over-shoot" hypoglycemia results from sustained translation of long-lived transgene message, and that reducing pro-insulin message half-life will ameliorate post-challenge hypoglycemia. Read More

    Low-after-high glucose down-regulated Cx43 in H9c2 cells by autophagy activation via cross-regulation by the PI3K/Akt/mTOR and MEK/ERK1/2 signal pathways.
    Endocrine 2017 Feb 8. Epub 2017 Feb 8.
    Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
    Purpose: Hypoglycemia in diabetes is a strong predictor of cardiovascular events. High-glucose have been reported to alter connexin43 expression and to promote autophagy in cardiomyocytes. We investigated whether low-after-high glucose would influence connexin43 expression and autophagy in H9c2 cells. Read More

    Fasting, Diabetes, and Optimizing Health Outcomes for Ramadan Observers: A Literature Review.
    Diabetes Ther 2017 Feb 8. Epub 2017 Feb 8.
    Faculty of Pharmacy, University of Sydney, Sydney, Australia.
    Introduction: Globally, and in Australia, diabetes has become a common chronic health condition. Diabetes is also quite prevalent in culturally and linguistically diverse pockets of the Australian population, including Muslims. There are over 90 million Muslims with diabetes worldwide. Read More

    Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin.
    J Clin Med Res 2017 Mar 25;9(3):193-199. Epub 2017 Jan 25.
    Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Background: The aim of this study was to investigate the efficacy and safety of vildagliptin as an add-on therapy for patients with type 2 diabetes mellitus inadequately controlled with basal insulin.

    Methods: Twenty-four patients treated with basal insulin and oral anti-diabetes drugs were randomly allocated into two groups: the control group (did not receive any add-on drugs) and vildagliptin group (received vildagliptin 100 mg/day for 6 months). The primary outcome was changes in hemoglobin A1c (HbA1c) from baseline to end of study. Read More

    Effects of oral vanadium on glycaemic and lipid profile in rats.
    J Pak Med Assoc 2016 Dec;66(12):1592-1596
    Department of Biochemistry & Molecular Biology, Army Medical College, National University of Medical Sciences (NUMS), Rawalpindi.
    Objective: Vanadyl sulphate, an inorganic tetravalent salt of transition metal vanadium is conventionally used to treat diabetes and by athletes as body-building supplement. Vanadyl sulphate is a constituent of many supplements and herbal preparations available over the counter in many parts of the world. In this study the efficacy of the salt as hypoglycaemic agent and its effects on lipid profile were determined when administered in therapeutic dose range (in humans) to healthy Sprague Dawley rats for a considerable duration. Read More

    Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.
    Neurology 2017 Feb 8. Epub 2017 Feb 8.
    From the Departments of Neurology (M.C.C., E.H.K., A.L.H., J.C.P., D.R.B., A.V., B.R., M.D., F.M.C., P.N.), Pediatrics (E.H.K., A.L.H.), and Anesthesiology-Critical Care Medicine (R.G.G.), Neurosurgery and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (S.H.), Mayo Clinic, Rochester, MN; Neuroscience Institute (M.K., E.C.H., D.D., T.S.), Queen's Medical Center, Honolulu, HI; Department of Neurology (B.B.), Loyola University Health System, Maywood, IL; Institute for Clinical and Translational Research (B.H.-B.), Johns Hopkins University, Baltimore, MD; and Department of Neurology (P.W.K.), Johns Hopkins Bayview Medical Center, Baltimore, MD.
    Objective: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults.

    Methods: We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Read More

    The diabetes management and daily functioning burden of non-severe hypoglycaemia in Japanese people treated with insulin.
    J Diabetes Investig 2017 Feb 8. Epub 2017 Feb 8.
    The Brod Group, 219 Julia Ave, Mill Valley, CA, 94941, USA.
    Aims: This study investigated the impact of non-severe hypoglycaemic events (NSHE) on patients' diabetes management, daily functioning and well-being.

    Methods: A survey assessing the impact of NSHEs was completed by insulin-treated Japanese people with diabetes, aged ≥20 years with self-reported diabetes, who had experienced at least one NSHE in the last 3 months. Survey questions captured reasons for and length of the event, and impacts on diabetes management, daily functioning, sleep and well-being. Read More

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