49,438 results match your criteria Hypoglycemia


Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion.

Aging (Albany NY) 2020 Jul 13;12. Epub 2020 Jul 13.

Emergency First Aid Linkage Center, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530201, P.R. China.

An intriguing area of research has demonstrated the ability of extracellular vesicles (EVs) as biological vehicles for microRNAs (miRNAs) transfer. Mesenchymal stem cells (MSCs) produce large amounts of EVs. Rat models of ischemia/reperfusion (I/R) were established to explore the expression profile of thioredoxin-interacting protein (TXNIP), which was then knocked-down to investigate its effects on myocardial remodeling, followed by detection on myocardial infarction size (MIS), myocardial collagen volume fraction (CVF) and cardiomyocyte apoptosis. Read More

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http://dx.doi.org/10.18632/aging.102792DOI Listing

Short stature and growth hormone deficiency in a subset of patients with Potocki-Lupski syndrome: Expanding the phenotype of PTLS.

Am J Med Genet A 2020 Jul 13. Epub 2020 Jul 13.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

Potocki-Lupski Syndrome (PTLS, MIM 610883), or duplication of chromosome 17p11.2, is a clinically recognizable condition characterized by infantile hypotonia, failure to thrive, developmental delay, intellectual disability, and congenital anomalies. Short stature, classified as greater than two standard deviations below the mean, has not previously been considered a major feature of PTLS. Read More

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http://dx.doi.org/10.1002/ajmg.a.61741DOI Listing

Sulfonylurea-Induced Hypoglycemia in a Patient With Cirrhosis.

Cureus 2020 Jun 8;12(6):e8513. Epub 2020 Jun 8.

Pharmacy, Robert J. Dole Veterans Affairs Medical Center, Wichita, USA.

Type 2 diabetes mellitus is highly prevalent among patients with cirrhosis. The pharmacological management of this disease in patients with chronic liver disease remains controversial, however. Insulin secretagogues such as sulfonylureas are associated with a high risk of hypoglycemia among diabetics. Read More

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http://dx.doi.org/10.7759/cureus.8513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346303PMC

A Family With a Complex Phenotype Caused by Two Different Rare Metabolic Disorders: GLUT1 and Very-Long-Chain Fatty Acid Dehydrogenase (VLCAD) Deficiencies.

Front Neurol 2020 23;11:514. Epub 2020 Jun 23.

Unit of Neurology and Neuromuscular Disorders, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

GLUT1 Deficiency Syndrome (GLUT1-DS) is a rare and potentially treatable neurometabolic condition, caused by a reduced glucose transport into the brain and clinically characterized by an epileptic encephalopathy with movement disorders. A wide inter-intrafamilial phenotypic variability has been reported. Very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an inherited metabolic disorder of mitochondrial long-chain fatty acid oxidation (FAO) with also a variable age of onset and clinical presentation including cardiomyopathy, hypoketotic hypoglycemia, and liver disease. Read More

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http://dx.doi.org/10.3389/fneur.2020.00514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324651PMC

Glucagon therapy in canines with an insulinoma: A retrospective descriptive study of 11 dogs.

Can Vet J 2020 Jul;61(7):737-742

Veterinary Emergency and Critical Care, 8650 W. Tropicana Avenue, Ste b107, Las Vegas, Nevada 89147, USA (Harris, Weatherton); Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts 02325, USA (Bloch).

Canine insulinomas are uncommon neoplasms, which often result in refractory hypoglycemia. Glucagon is one readily available treatment for insulin-induced hypoglycemia. The primary objective of this study was to evaluate blood glucose trends and outcome (survival to discharge death or euthanasia) for dogs with insulinoma that were treated with glucagon. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296875PMC

Hospitalization Costs Due to Hypoglycemia in Patients with Diabetes: A Microcosting Approach.

Diabetes Ther 2020 Jul 11. Epub 2020 Jul 11.

MSD Portugal, Paço de Arcos, Portugal.

Introduction: Hypoglycemia leading to hospitalization is associated with adverse economic outcomes, although the real burden is unknown. The HIPOS-WARD (Hypoglycemia In Portugal Observational Study-Ward) aimed to characterize ward admissions due to hypoglycemia episodes in treated patients with diabetes and assess their economic impact to the National Health System.

Methods: Observational, cross-sectional study, conducted in 16 Portuguese centers for 22 months. Read More

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http://dx.doi.org/10.1007/s13300-020-00868-0DOI Listing

Clinical manifestations and management of fatty acid oxidation disorders.

Rev Endocr Metab Disord 2020 Jul 11. Epub 2020 Jul 11.

Indiana University School of Medicine, Indianapolis, IN, USA.

Fatty acid oxidation disorders (FAOD) are a group of rare, autosomal recessive, metabolic disorders caused by variants of the genes for the enzymes and proteins involved in the transport and metabolism of fatty acids in the mitochondria. Those affected by FAOD are unable to convert fatty acids into tricarboxylic acid cycle intermediates such as acetyl-coenzyme A, resulting in decreased adenosine triphosphate and glucose for use as energy in a variety of high-energy-requiring organ systems. Signs and symptoms may manifest in infants but often also appear in adolescents or adults during times of increased metabolic demand, such as fasting, physiologic stress, and prolonged exercise. Read More

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http://dx.doi.org/10.1007/s11154-020-09568-3DOI Listing

Safely finishing a half marathon by an adult with type 1 diabetes using a commercially available hybrid closed-loop system.

J Diabetes Investig 2020 Jul 11. Epub 2020 Jul 11.

Medical University of Graz, Endocrinology and Diabetology, Auenbruggerplatz 15, Graz, Steiermark, AT 8036, Austria.

Glycemic targets are often difficult to achieve in people with type 1 diabetes (T1D), especially during exercise. Consequently, many people with T1D avoid sports due to fear of hypoglycemia. Strenuous physical activity such as a half marathon imposes difficulties on people with T1D. Read More

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http://dx.doi.org/10.1111/jdi.13356DOI Listing

Why Do Falls and Lower Limb Fractures Occur More Frequently in the Diabetic Patient and How Can They Be Prevented?

Diabetes Ther 2020 Jul 10. Epub 2020 Jul 10.

Southside Endocrinology and Diabetes and Thyroid Associates, Birmingham, AL, USA.

Due to primarily sarcopenia and hypoglycemia but also neuropathy, hypotension, analgesics and polypharmacy, there is an increased incidence of falls and hip fractures in both the type 1 and type 2 diabetic patient. Utilization of insulin, hypotensive drugs, analgesics and perhaps canagliflozin further increases the risk. Thiazolidinedione use may increase the risk of osteoporosis and fracture. Read More

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http://dx.doi.org/10.1007/s13300-020-00877-zDOI Listing

Persistence with Basal Insulin and Frequency of Hypoglycemia Requiring Hospitalization in Patients with Type 2 Diabetes.

Diabetes Ther 2020 Jul 10. Epub 2020 Jul 10.

Endocrinology Department, Nantes University Hospital Hotel-Dieu, Nantes, France.

Introduction: A second-generation basal insulin analogue insulin glargine 300 U/mL (Gla-300) has been marketed in France since June 2016. This real-world study was designed to assess persistence with Gla-300 and the prevalence of related hypoglycemia requiring hospitalization as compared to first-generation basal insulins, in patients with type 2 diabetes mellitus (T2DM).

Methods: A retrospective study was conducted using data in the large French comprehensive national healthcare system claims databases. Read More

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http://dx.doi.org/10.1007/s13300-020-00874-2DOI Listing

Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery.

Chin Med J (Engl) 2020 Jul 7. Epub 2020 Jul 7.

Key Laboratory of Endocrinology, Translational Medicine Center, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Obesity has become a global health problem. Lifestyle modification and medical treatment only appear to yield short-term weight loss. Roux-en-Y gastric bypass (RYGB) is the most popular bariatric procedure, and it sustains weight reduction and results in the remission of obesity-associated comorbidities for obese individuals. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000932DOI Listing

Evaluation of an Intrapartum Insulin Regimen for Women With Diabetes.

Obstet Gynecol 2020 Jul 9. Epub 2020 Jul 9.

Divisions of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology, University of Chicago and Northwestern University, Chicago, Illinois.

Objective: To examine whether an insulin protocol for intrapartum glucose control among parturients with diabetes was associated with improved outcomes.

Methods: This is a retrospective cohort study of women with pregestational or gestational diabetes delivering a liveborn neonate at Northwestern Memorial Hospital. Before 2011, women with diabetes were given intravenous (IV) insulin or glucose during labor at the discretion of the on-call endocrinologist. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003940DOI Listing

Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man.

Oman Med J 2020 May 30;35(3):e134. Epub 2020 Jun 30.

Islamabad Diagnostic Center, Islamabad, Pakistan.

Type B insulin resistance syndrome (TBIRS) has not been previously reported in Arab populations. We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. Read More

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http://dx.doi.org/10.5001/omj.2020.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335451PMC

Influenza Vaccination Is Associated With Reduced Cardiovascular Mortality in Adults With Diabetes: A Nationwide Cohort Study.

Diabetes Care 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Objective: Recent influenza infection is associated with an increased risk of atherothrombotic events, including acute myocardial infarction (AMI) and stroke. Little is known about the association between influenza vaccination and cardiovascular outcomes in patients with diabetes.

Research Design And Methods: We used nationwide register data to identify patients with diabetes in Denmark during nine consecutive influenza seasons in the period 2007-2016. Read More

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http://dx.doi.org/10.2337/dc20-0229DOI Listing

Effect of High-Intensity Interval Training on Glycemic Control in Adults With Type 1 Diabetes and Overweight or Obesity: A Randomized Controlled Trial With Partial Crossover.

Diabetes Care 2020 Jul 9. Epub 2020 Jul 9.

Department of Endocrinology, Diabetes Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

Objective: To study the effect of 12 weeks of high-intensity interval training (HIIT) on glycemic control in adults with type 1 diabetes and overweight or obesity.

Research Design And Methods: Thirty inactive adults with type 1 diabetes who had BMI ≥25 kg/m and HbA ≥7.5% were randomized to 12 weeks of either HIIT exercise intervention consisting of 4 × 4-min HIIT (85-95% peak heart rate) performed thrice weekly or usual care control. Read More

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http://dx.doi.org/10.2337/dc20-0342DOI Listing

Long-term Cost-Effectiveness of Dexcom G6 Real-Time Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Patients With Type 1 Diabetes in the U.K.

Diabetes Care 2020 Jul 9. Epub 2020 Jul 9.

Dexcom, San Diego, CA.

Objective: A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). Read More

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http://dx.doi.org/10.2337/dc19-2213DOI Listing

Effect of in-hospital glycemic variability on mortality in patients with diabetes.

Rev Clin Esp 2020 Jul 6. Epub 2020 Jul 6.

Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, España; Servicio de Urgencias, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address:

Introduction: The aim of this study was to evaluate the impact of mean blood glucose (MBG) and glycaemic variability (GV) during hospitalisation on mortality after discharge.

Material And Methods: We conducted a retrospective longitudinal analytical cohort study that included patients discharged form a department of internal medicine with a diabetes-related diagnosis The evaluated prognosis was mortality. During hospitalisation, the patients' clinical, laboratory and glycaemic control-related variables were recorded (MBG, GV and hypoglycaemia). Read More

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http://dx.doi.org/10.1016/j.rce.2019.12.014DOI Listing

Diurnal patterns of objectively measured sedentary time and interruptions to sedentary time are associated with glycaemic indices in type 2 diabetes.

J Sci Med Sport 2020 Jun 21. Epub 2020 Jun 21.

School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom; Department of Movement and Sports Science, Ghent University, Ghent, Belgium.

Objectives: To investigate diurnal patterns of sedentary time and interruptions to sedentary time and their associations with achievement of pre-meal glucose, post-meal glucose, bedtime glucose and the dawn phenomenon targets and with duration of hypoglycaemia, euglycaemia, hyperglycaemia and above target range.

Design: Intensive longitudinal study.

Methods: In 37 adults with type 2 diabetes, the FreeStyle Libre and activPAL3 were used to monitor glucose and sedentary time and interruptions to sedentary time in the morning (07:00-12:00), afternoon (12:00-17:00) and evening (17:00-23:00) for 14 days. Read More

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http://dx.doi.org/10.1016/j.jsams.2020.06.003DOI Listing

[Blood-glucose control in eldely patients with type 2 diabetes. Interventions to avoid risks].

Semergen 2020 Jul 6. Epub 2020 Jul 6.

Centro de Salud Virgen de la Concha, Zamora. España.

Objective: To evaluate blood-glucose control in elderly patients with type 2 diabetes mellitus (T2DM), who are receiving various anti-diabetic treatments, and to analyse the effect of an intervention.

Material And Methods: Cross-sectional, descriptive, and observational study of prevalence that included patients who were ≥75 years old with T2DM and being treated with two or more antidiabetic drugs. The adequacy of treatments following current recommendations for this population group was analysed, together with the prevalence of macro- and micro-vascular complications, dementia, and hypoglycaemia, the treatments used, and adherence. Read More

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http://dx.doi.org/10.1016/j.semerg.2020.01.006DOI Listing

Isolated growth hormone deficiency in a Chihuahua with a mutation.

J Vet Diagn Invest 2020 Jul 9:1040638720938671. Epub 2020 Jul 9.

Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

A 6-mo-old female Chihuahua was presented with recurrent episodes of hypoglycemia and collapse. Physical examination revealed proportionate dwarfism, retained puppy hair coat, retained deciduous teeth, and open fontanelles. Routine blood tests revealed hypoglycemia, thrombocytosis, hypoproteinemia, and elevated alkaline phosphatase activity. Read More

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http://dx.doi.org/10.1177/1040638720938671DOI Listing

Features of oral glucose tolerance test in patients after Roux-en-Y gastric bypass with and without hypoglycaemia symptoms in daily life: it's all about speed.

Diabetes Obes Metab 2020 Jul 9. Epub 2020 Jul 9.

Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Antwerp, Belgium.

Objective: Hypoglycaemia is a disabling complication of Roux-en-Y gastric bypass (RYGB). This study evaluates the glucose and insulin profiles during an oral glucose tolerance test (OGTT) in symptomatic and asymptomatic patients.

Research Design And Methods: This retrospective study consisted of two groups that had a RYGB. Read More

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http://dx.doi.org/10.1111/dom.14130DOI Listing

Practical guidance for use of oral semaglutide in primary care: a narrative review.

Postgrad Med 2020 Jul 9:1-10. Epub 2020 Jul 9.

Abington Family Medicine , Jenkintown, PA, USA.

As the cornerstone of type 2 diabetes (T2D) management within the community, primary care providers are now faced with the challenge of not only managing diabetes itself, but also preventing hypoglycemia and weight gain associated with intensive disease management, and reducing cardiovascular risk. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are well established as efficacious treatments for T2D, and the safety/tolerability profile of this drug class is well defined. However, despite their beneficial effects, GLP-1RAs are under-utilized, highlighting the need for novel approaches to increase their use in primary care. Read More

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http://dx.doi.org/10.1080/00325481.2020.1788340DOI Listing

Patient-Reported Outcomes with Insulin Glargine 300 U/mL in People with Type 2 Diabetes: The MAGE Multicenter Observational Study.

Diabetes Ther 2020 Jul 8. Epub 2020 Jul 8.

Department of Endocrinology, Diabetes and Metabolism, Antwerp University Hospital, 2650, Egedem/Antwerp, Belgium.

Introduction: MAGE was a Multicenter, single-Arm, observational 6-month (plus 6-month extension) study that aimed to assess treatment satisfaction, efficacy, and safety of insulin Glargine 300 U/mL (Gla-300) in people with type 2 diabetes (T2DM) receiving basal-bolus insulin in a rEal-world setting.

Materials And Methods: Participants were at least 18 years old, with T2DM for more than 1 year, HbA 7.0-10. Read More

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http://dx.doi.org/10.1007/s13300-020-00866-2DOI Listing

An autopsy case of primary jejunal pouch cancer which protruded from the abdominal wall 14 years after total gastrectomy for gastric cancer.

Clin J Gastroenterol 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Adenocarcinoma which develops in the jejunal pouch has rarely been reported, but most of such cases tend to be a recurrence of primary cancer due to the presence of residual or disseminated cancer cells. Primary jejunal pouch cancer is extremely rare. We experienced an autopsy case of primary jejunal pouch cancer which occurred 14 years after proximal gastrectomy for gastric cancer. Read More

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http://dx.doi.org/10.1007/s12328-020-01177-6DOI Listing

Low ALT Values amongst Hospitalized Patients are Associated with Increased Risk of Hypoglycemia and Overall Mortality. A Retrospective, Big-data Analysis of 51,831 Patients.

QJM 2020 Jul 8. Epub 2020 Jul 8.

Internal Medicine "T". Chaim Sheba medical center, Tel-Hashomer, Ramat-Gan, Israel.

Background: Sarcopenia and frailty influence clinical patients' outcomes. Low ALT serum activity is a surrogate marker for sarcopenia and frailty. In-hospital hypoglycemia is associated, also with worse clinical outcomes. Read More

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http://dx.doi.org/10.1093/qjmed/hcaa219DOI Listing

The Association Between HbA and Time in Hypoglycemia During CGM and Self-Monitoring of Blood Glucose in People With Type 1 Diabetes and Multiple Daily Insulin Injections: A Randomized Clinical Trial (GOLD-4).

Diabetes Care 2020 Jul 8. Epub 2020 Jul 8.

Department of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden.

Objective: According to recent guidelines, individuals with type 1 diabetes should spend <4.0% per day with glucose levels <3.9 mmol/L (<70 mg/dL) and <1. Read More

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http://dx.doi.org/10.2337/dc19-2606DOI Listing

Comparison of the FreeStyle Libre Pro Flash Continuous Glucose Monitoring (CGM) System and Point-of-Care Capillary Glucose Testing (POC) in Hospitalized Patients With Type 2 Diabetes (T2D) Treated With Basal-Bolus Insulin Regimen.

Diabetes Care 2020 Jul 8. Epub 2020 Jul 8.

Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, GA

Objective: We compared the performance of the FreeStyle Libre Pro continuous glucose monitoring (CGM) and point-of-care capillary glucose testing (POC) among insulin-treated hospitalized patients with type 2 diabetes (T2D).

Research Design And Methods: Prospective study in adult patients with T2D admitted to general medicine and surgery wards. Patients were monitored with POC before meals and bedtime and with CGM during the hospital stay. Read More

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http://dx.doi.org/10.2337/dc19-2073DOI Listing

Effects of Sotagliflozin Combined with Intensive Insulin Therapy in Young Adults with Poorly Controlled Type 1 Diabetes: The JDRF Sotagliflozin Study.

Diabetes Technol Ther 2020 Jul 8. Epub 2020 Jul 8.

Lexicon Pharmaceuticals Inc, 57636, The Woodlands, Texas, United States;

Background: Young adults with type 1 diabetes (T1D) tend to have higher A1C than older adults and are at increased risk for diabetic ketoacidosis (DKA). Oral adjuncts to insulin have not been previously studied in this population.

Methods: In this phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group study, adults aged 18-30 years with T1D and A1C ≥9. Read More

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http://dx.doi.org/10.1089/dia.2020.0079DOI Listing

Compatibility and Safety of Ultra Rapid Lispro with Continuous Subcutaneous Insulin Infusion in Patients With Type 1 Diabetes: PRONTO-Pump Study.

Diabetes Technol Ther 2020 Jul 8. Epub 2020 Jul 8.

Eli Lilly and Company, Medical, Lilly Corporate Center, Indianapolis, Indiana, United States, 46285;

Background Ultra rapid lispro (URLi) is a new insulin lispro formulation that has accelerated absorption and improved postprandial glucose control compared to insulin lispro (Humalog®). The compatibility and safety of URLi versus lispro were evaluated in patients with type 1 diabetes using continuous subcutaneous insulin infusion (CSII, insulin pump). Methods In this Phase 3, double-blind, crossover study, 49 patients were randomized to two 6-week treatment periods, following a 2-week lead-in period on lispro. Read More

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http://dx.doi.org/10.1089/dia.2020.0224DOI Listing

Risk Factors for Intraoperative Hypoglycemia in Children: A Multicenter Retrospective Cohort Study.

Anesth Analg 2020 Jun 25. Epub 2020 Jun 25.

From the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan.

Background: Intraoperative hypoglycemia can result in devastating neurologic injury if not promptly diagnosed and treated. Few studies have defined risk factors for intraoperative hypoglycemia. The authors sought to characterize children with intraoperative hypoglycemia and determine independent risk factors in a multicenter cohort. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004979DOI Listing

Malignant insulinoma, a very rare cause of pediatric hypoglycemia.

J Biol Regul Homeost Agents 2020 May-Jun;34(3):1167-1170

G. Martino Hospital, Pediatric Unit, Department of Adulthood and Chilhood Human Pathology, University of Messina, Messina, Italy.

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http://dx.doi.org/10.23812/19-478-L-1DOI Listing

People with type 1 diabetes and impaired awareness of hypoglycaemia have a delayed reaction to performing a glucose scan during hypoglycaemia: a prospective observational study.

Diabet Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Aim: Considering that people with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) have a delayed perception of hypoglycaemia, the question arises whether they perform scans later in case of hypoglycaemia than people without IAH. We assessed whether time to performing a scan after reaching hypoglycaemia while using a flash glucose monitoring (flash GM) system is different in people with IAH compared with people without IAH.

Methods: Ninety-two people with type 1 diabetes [mean (± sd) age 42 ± 14 years, HbA 57 ± 9 mmol/mol] using a flash GM system for 3 months were included. Read More

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http://dx.doi.org/10.1111/dme.14362DOI Listing

Relationship between serum insulin and point-of-admission blood glucose of ill neonates at a tertiary health facility in Nigeria.

Pan Afr Med J 2020 8;35:106. Epub 2020 Apr 8.

Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria.

Introduction: Optimal glucose metabolism is important in neonatal survival especially in the first days of life. Insulin play a significant role in maintaining blood glucose homeostasis. This study set out to determine the serum insulin levels of ill neonates as related to their point-of-admission blood glucose estimation at the Wesley Guild Hospital, Ilesa, Nigeria. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.106.18929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320779PMC

Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Introduction: Impaired awareness of hypoglycemia (IAH) is a common complication in patients with type-1 diabetes (T1D). IAH is a major risk factor for severe hypoglycemic events, leading to adverse clinical consequences and cerebral damage. Non-invasive, cost-effective, and logistically efficient biomarkers for this condition have not been validated. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342474PMC

Efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes: a meta-analysis of randomized controlled trials.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Italy.

Introduction: Insulin is the most effective antihyperglycemic treatment and basal insulin is the preferred initial formulation in patients with type 2 diabetes. However, its effects are dose-dependent, so adequate titration is necessary to reach targets. We performed a meta-analysis to compare the efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342431PMC

Nighttime Hypoglycemia in Children with Type 1 Diabetes after one Day of Football Tournament.

Int J Sports Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.

The aim of the study was to investigate factors related to the occurrence of nighttime hypoglycemia after a football tournament in children with type 1 diabetes mellitus. The multicenter study (GoalDiab study) included 189 children and adolescents with type 1 diabetes mellitus, from 11 diabetes care centers in Poland. Hypoglycemia was defined according to the International Hypoglycemia Study Group Statement. Read More

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http://dx.doi.org/10.1055/a-1192-5992DOI Listing

Cost-Utility Analysis of Prophylactic Dextrose Gel vs. Standard Care for Neonatal Hypoglycemia In At-Risk Infants.

J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Liggins Institute, University of Auckland, Auckland, New Zealand. Electronic address:

Objective: To evaluate the long-term costs and impact on quality of life of using prophylactic dextrose gel in subjects at increased risk of developing neonatal hypoglycemia.

Study Design: A cost-utility analysis was performed from the perspective of the health system, using a decision tree to model the long-term clinical outcomes of neonatal hypoglycemia, including cerebral palsy, epilepsy, vision disturbances, and learning disabilities, in subjects at increased risk of neonatal hypoglycemia who received prophylactic dextrose gel vs standard care. Model parameters including likelihoods of hypoglycemia and admission to a neonatal intensive care unit, were based on the pre-hPOD Study. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.073DOI Listing

Octreotide-related exocrine pancreatic insufficiency (EPI) in congenital hyperinsulinism.

J Pediatr Endocrinol Metab 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

Background Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn. Octreotide, a long-acting somatostatin receptor analog (SSRA), is a second line treatment for diazoxide unresponsive CH patients. Although it has been found to be a safe and effective treatment, long-term benefits and side effects, have not been thoroughly evaluated. Read More

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http://dx.doi.org/10.1515/jpem-2019-0565DOI Listing

Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management.

Sci Rep 2020 Jul 6;10(1):11061. Epub 2020 Jul 6.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Jorge Viterbo Ferreira 228, Ed.1, 3rd Floor, 4050-313, Porto, Portugal.

Our aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N = 13) with suspected PBH underwent a food and symptoms diary (FSD) record along with FGM over 14 days. Targeted data analysis confirmed the occurrence of low glucose events in parallel to meal-triggered symptoms. Read More

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http://dx.doi.org/10.1038/s41598-020-68029-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338422PMC

Prediction of Hypoglycemia During Admission of Non-Critically Ill Patients: Results from the MENU Study.

Horm Metab Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine A, Yoseftal Hospital, Eilat, Israel.

The objective of the work was to study admission parameters associated with an increased incidence of hypoglycemia during hospitalization of non-critically ill patients. Included in this cross-sectional study were patients admitted to internal medicine units. The Nutritional Risk Screening 2002 (NRS2002) was used for nutritional screening. Read More

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http://dx.doi.org/10.1055/a-1181-8781DOI Listing

Impact of insulin pump therapy on key parameters of diabetes management and diabetes related emotional distress in the first 12 months.

Diabetes Res Clin Pract 2020 Jul 3:108281. Epub 2020 Jul 3.

Department of Diabetes and Endocrinology, Diabetes centre, Prince Charles hospital, Cwm Taf Morgannwg University Health Board, Merthyr Tydfil, CF47 9DT, United Kingdom. Electronic address:

Aims: To evaluate the effect of continuous subcutaneous insulin infusion (CSII) on glycaemic control, hypoglycaemia and emotional distress in adults with type 1 diabetes (T1D) during the first 12 months.

Methods: 47 patients were started on CSII as per NICE guidelines. Anthropometric, clinical and biochemical parameters, hypoglycaemia rates and emotional distress measured by Problem Areas in Diabetes questionnaires (PAID) were recorded at baseline and during follow up at 3-6 months and 6-12 months. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108281DOI Listing

Tumorigenic Potential of Granulocyte Colony-Stimulating Factor Therapy-A Case Report and Review of Literature.

J Oral Maxillofac Surg 2020 Jun 10. Epub 2020 Jun 10.

Assistant Professor of Surgery and Residency Program Director, Department of Oral and Maxillofacial Surgery, Parkland/UT Southwestern, Dallas, TX.

An association between granulocyte colony-stimulating factor therapy (G-CSFT) in patients with glycogen storage disease type Ib (GSDIb) and the development of giant cell lesions of the maxillofacial complex has emerged. We have reported, to the best of our knowledge, the fourth case of giant cell granuloma (GCG) in a patient with GSDIb undergoing G-CSFT. GSDIb can present with hypoglycemia, hypertriglyceridemia, and neutropenia. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.006DOI Listing

Fixed-Ratio Combinations of Basal Insulin and Glp-1ra in the Management of Type 2 Diabetes Mellitus: Highlight from Literature.

Endocr Metab Immune Disord Drug Targets 2020 Jul 5. Epub 2020 Jul 5.

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases. University of Bari "Aldo Moro", Bari. Italy.

Introduction: New evidences suggest that combining basal insulin with glucagone-like peptide 1 receptor agonists (GLP-1RA) in patients with type 2 diabetes could promptly ameliorate the glucose control and prevent both hypoglycaemia and weight gain compared with more intensive insulin regimens.

Aim Of The Study: To review the efficacy/effectiveness and safety of fixed-ratio combinations of basal insulin and GLP-1RA (FRCs).

Methods: We asked the web for freely available medical data concerning the aim of the study, and selected original articles, randomized clinical trials (RCTs), clinical reviews, and meta-analysis written in English. Read More

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http://dx.doi.org/10.2174/1871530320666200705211224DOI Listing

Implementation of a Weight-Based Protocol for the Management of Steroid-Induced Hyperglycemia.

Am J Ther 2020 Jul/Aug;27(4):e392-e399

1Department of Internal Medicine, Division of Endocrinology, North Shore University Hospital, Manhasset, NY; 2Donald and Barbara Zucker School of Medicine at Northwell, Hempstead, NY; 3Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY; 4Department of Internal Medicine, North Shore University Hospital, Manhasset, NY; 5Department of Pharmacy, North Shore University Hospital, Manhasset, NY; and 6Department of Pharmacy, St. John's University, Jamaica, NY.

Background: Hyperglycemia is a recognized complication of supraphysiological steroid dosing. There are no consensus guidelines on optimal treatment of steroid-induced hyperglycemia. We assessed the safety of a weight-based insulin protocol for persons treated with supraphysiological doses of steroids to examine the efficacy of using this protocol in patients with diabetes treated with prednisone or methylprednisolone. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000998DOI Listing

The influence of selenium deficiency on chosen biochemical parameters and histopathological changes in muscles of goat kids.

Pol J Vet Sci 2020 Jun;23(2):267-279

Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-957 Olsztyn, Poland.

The research was conducted on 40 young alpine goats (kids) divided into two groups. First group consisted of 20 kids demonstrating clinical signs of muscular dystrophy. Second group was a control and consisted of 20 animals that received intramuscular injection (2ml per animal) of vitamin E and selenium preparation containing in 1ml 50 mg of tocopherol acetate, 0. Read More

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http://dx.doi.org/10.24425/pjvs.2020.133642DOI Listing

Phase 3 Trial of Human Islet-after-Kidney Transplantation in Type 1 Diabetes.

Am J Transplant 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, University of Texas Dell Medical School, Austin, Texas, USA.

Allogeneic islet transplantation offers a minimally invasive option for β-cell replacement in the treatment of type 1 diabetes (T1D). The CIT consortium trial of purified human pancreatic islets (PHPI) in patients with T1D after kidney transplantation (CIT06), a National Institutes of Health (NIH)-sponsored phase 3, prospective, open-label, single-arm pivotal trial of PHPI, was conducted in 24 patients with impaired awareness of hypoglycemia while receiving intensive insulin therapy (IIT). PHPI were manufactured using standardized processes. Read More

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http://dx.doi.org/10.1111/ajt.16174DOI Listing

Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists (GLP-1RAs): a systematic literature review and indirect treatment comparison.

Diabetes Obes Metab 2020 Jul 6. Epub 2020 Jul 6.

Doctor Evidence, Santa Monica, CA, USA.

Aims: To estimate the relative treatment effect between the fixed ratio combinations (FRCs) iGlarLixi and IDegLira (glucagon-like peptide 1 receptor agonist [GLP-1RA] with basal insulin) in people with type 2 diabetes (T2D) inadequately controlled on a GLP-1RA.

Materials And Methods: A systematic literature review of randomized controlled trials followed by an indirect treatment comparison (ITC) was performed to compare the efficacy and safety of the available FRCs. Main outcomes were HbA1c change and target achievement (<6. Read More

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http://dx.doi.org/10.1111/dom.14136DOI Listing