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Medicine (Baltimore) 2019 Feb;98(7):e14529

Department of Pediatric Nephrology.

Rationale: Medullary sponge kidney (MSK) is a rare congenital abnormality characterized by cystic dilatation of the medullary collecting tubules. The disorder is likely to be complicated by nephrocalcinosis, urolithiasis, tubular dysfunctions, and urinary tract infections. In addition, it may be rarely associated with extrarenal anomalies. Read More

Urologiia 2018 Oct(4):19-23

Clinic of Urology and Nephrology, Institute of Postgraduate Medical Education, Tashkent, Uzbekistan.

Drugs for preventing stone formation can be selected based on the average regional indicators, which have features depending on the region of the world.

Aim: To investigate the features of urinary factors for lithogenesis (UFL) of calcium urolithiasis in Tashkent and evaluate the variants of their pharmacological correction.

Materials And Methods: The study analyzed data from 779 patients with calcium urolithiasis. Read More

J Pediatr (Rio J) 2019 Feb 5. Epub 2019 Feb 5.

Universidade Federal de Santa Catarina (UFSC), Centro de Ciências da Saúde, Departamento de Pediatria, Florianópolis, SC, Brazil; Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil; Hospital Infantil Joana de Gusmão, Unidades de Nefrologia Pediátrica e de Terapia Intensiva, Florianópolis, SC, Brazil Received 31 August 2018; accepted 31 October 2018. Electronic address:

Objective: To describe the dietary patterns and occurrence of metabolic disorders in children and adolescents with urolithiasis treatment at a referral hospital in southern Brazil in order to learn the features of urolithiasis in this population to better develop preventive actions.

Methods: Descriptive study conducted between 2016 and 2017 in a tertiary care referral hospital. Fourty patients aged 2-19 years old with urolithiasis proven by imaging were included. Read More

Int Braz J Urol 2019 Jan 4;45. Epub 2019 Jan 4.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Purpose: To better characterize metabolic stone risk in patients with neurologically derived musculoskeletal deficiencies (NDMD) by determining how patient characteristics relate to renal calculus composition and 24-hour urine parameters.

Materials And Methods: We performed a retrospective cohort study of adult patients with neurologically derived musculoskeletal deficiencies presenting to our multidisciplinary Kidney Stone Clinic. Patients with a diagnosis of NDMD, at least one 24-hour urine collection, and one chemical stone analysis were included in the analysis. Read More

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada.

Background: The incidence of nephrolithiasis in children and adolescents is increasing and appears to double every 10 years. The most important role of the pediatric nephrologist is to diagnose and modify various metabolic and non-metabolic risk factors, as well as prevent long-term complications especially in the case of recurrent nephrolithiasis.

Objective: The purpose of this review is to summarize the existing literature on the etiology and management of pediatric nephrolithiasis. Read More

Pediatric Health Med Ther 2018 12;9:181-190. Epub 2018 Dec 12.

Department of Pediatrics, Niigata City General Hospital, Niigata City 950-1197, Japan,

Primary distal renal tubular acidosis (dRTA) is a rare genetic disorder caused by impaired distal acidification due to a failure of type A intercalated cells (A-ICs) in the collecting tubule. dRTA is characterized by persistent hyperchloremia, a normal plasma anion gap, and the inability to maximally lower urinary pH in the presence of systemic metabolic acidosis. Common clinical features of dRTA include vomiting, failure to thrive, polyuria, hypercalciuria, hypocitraturia, nephrocalcinosis, nephrolithiasis, growth delay, and rickets. Read More

Acta Biomed 2018 Dec 17;89(9-S):76-80. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background And Aim Of The Work: Historical studies have demonstrated that the prevalence of symptomatic nephrolithiasis is higher in patients with inflammatory bowel disease (IBD), compared to general population. The aim of the review was to analyze literature data in order to identify the main risk conditions described in literature and the proposed treatment.

Methods: A research on the databases PubMed, Medline, Embase and Google Scholar was performed by using the keywords "renal calculi/lithiasis/stones" and "inflammatory bowel diseases". Read More

Curr Opin Nephrol Hypertens 2019 Mar;28(2):130-139

Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Purpose Of Review: Calcium phosphate (CaP) stones represent an increasingly encountered form of recurrent nephrolithiasis, but current prophylactic medical regimens are suboptimal. Although hypocitraturia is a well-described risk factor for CaP stones, strategies that enhance citrate excretion have not consistently been effective at reducing CaP saturation and stone recurrence. This review summarizes the role of citrate therapy in CaP nephrolithiasis. Read More

J Pediatr Urol 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hematuria, either macroscopic or microscopic, is an incidental finding of multiple nephrologic or urologic disorders. Disturbances of urine inhibitors or promotors have been suggested as the potential causes of isolated idiopathic hematuria in children and its recurrence. Meanwhile, appropriate treatment of these risk factors might improve secondary asymptomatic or macroscopic hematuria. Read More

Rev Paul Pediatr 2018 Jul-Sep;36(3):261-267

Universidade Federal Fluminense, Niterói, RJ, Brasil.

Objective: To describe the frequency, clinical profile and treatment of patients with urolithiasis in the Pediatric Nephrology Department of a public state hospital in Rio de Janeiro, Brazil.

Methods: Retrospective study. Data from pediatric patients (age: 1 month - 18 years) with urolithiasis admitted between January/2012 and December/2014 were reviewed from hospital charts. Read More

J Urol 2018 Nov 7;200(5):939-940. Epub 2018 Aug 7.

Int Urol Nephrol 2018 Nov 12;50(11):1949-1954. Epub 2018 Sep 12.

Department of Pediatric Urology, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI, 48201, USA.

Purpose: To study (1) the differences in the relative abundance of urinary proteins between children with kidney stones (RS) and hypercalciuria, hypocitraturia, normal metabolic work-up, and healthy controls (HC); (2) the association of these proteins with various diseases.

Methods: Quantitative proteomic comparison of pooled urine from RS (N = 30, 24 females, mean age 12.95 ± 4. Read More

J Pediatr Urol 2018 Aug 7;14(4):331.e1-331.e6. Epub 2018 Aug 7.

Department of Urology, 535 Barnhill Dr. Indianapolis, IN, 46202, USA.

Introduction: American Urological Association guidelines recommend a urinary metabolic evaluation after the first stone event in all pediatric stone patients. Prior studies identified hypercalciuria and urine hypovolemia as the most common abnormalities in children with urolithiasis. Recent data suggest that hypocitraturia is most prevalent. Read More

Genes Genomics 2018 09 17;40(9):965-972. Epub 2018 May 17.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Hypocitraturia is a profound risk for kidney stone formation and recurrence. Sodium-dicarboxylate cotransporter-1 (NaDC-1) is a main transporter responsible for citrate reabsorption in renal proximal tubules. To investigate an association of sodium-dicarboxylate cotransporter-1 (NaDC-1) polymorphism with hypocitraturia in Thai patients with nephrolithiasis (NL). Read More

Adv Chronic Kidney Dis 2018 Jul;25(4):366-374

Division of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern; Swiss National Centre of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland; and the Departments of Internal Medicine and Physiology, and the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX.

Renal tubular acidosis (RTA) is comprised of a diverse group of congenital or acquired diseases with the common denominator of defective renal acid excretion with protean manifestation, but in adults, recurrent kidney stones and nephrocalcinosis are mainly found in presentation. Calcium phosphate (CaP) stones and nephrocalcinosis are frequently encountered in distal hypokalemic RTA type I. Alkaline urinary pH, hypocitraturia, and, less frequently, hypercalciuria are the tripartite lithogenic factors in distal RTA (dRTA) predisposing to CaP stone formation; the latter 2 are also commonly encountered in other causes of urolithiasis. Read More

Adv Chronic Kidney Dis 2018 Jul;25(4):303-320

Pathophysiology Division, Pathology Department, School of Medicine, National University of Cuyo, Mendoza, Argentina; and Division of Nephrology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL. Electronic address:

Distal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic acidosis with impaired urinary acid excretion in the presence of a normal or moderately reduced glomerular filtration rate. Failure in urinary acid excretion results from reduced H secretion by intercalated cells in the distal nephron. This results in decreased excretion of NH and other acids collectively referred as titratable acids while urine pH is typically above 5. Read More

J Endourol 2018 Sep 3;32(9):878-883. Epub 2018 Aug 3.

3 Glickman Urological and Kidney Institute , Cleveland Clinic Foundation, Cleveland, Ohio.

Introduction And Objectives: Studies have demonstrated associations between nephrolithiasis and systemic conditions, including low bone mineral density (BMD), which may correlate with hypercalciuria in kidney stone formers (KSFs). Traditionally, low BMD is diagnosed with dual-energy X-ray absorptiometry. As a noncontrast CT (NCCT) scan is typically part of a stone evaluation, our objective was to evaluate the association of NCCT-based vertebral BMD with 24-hour urine parameters in KSF. Read More

Urolithiasis 2018 Jun 20. Epub 2018 Jun 20.

Department of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.

Idiopathic hypocitraturia (IH) is a risk factor for urolithiasis. IH is associated with vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in a Chinese Han population. However, this association between VDR SNPs and IH has not been recapitulated in a Chinese Bai population. Read More

J Pediatr Urol 2018 Aug 7;14(4):330.e1-330.e8. Epub 2018 Jun 7.

Division of Pediatric Nephrology, Department of Pediatrics, University of Kentucky, Lexington, KY, USA. Electronic address:

Introduction: The prevalence of pediatric nephrolithiasis has increased significantly in the past 20 years. Metabolic abnormalities predisposing adults to nephrolithiasis in obese patients include increased urinary sodium and uric acid excretion as well as low urine pH; however, limited data are available in the pediatric population.

Objective: The aim was to investigate whether obese pediatric patients presenting with nephrolithiasis have a unique metabolic profile similar to reported findings in obese adults with nephrolithiasis. Read More

J Bone Miner Res 2018 Oct 22;33(10):1741-1747. Epub 2018 Jun 22.

Skeletal Distorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

Subcutaneous human parathyroid hormone (hPTH) therapy can effectively manage hypocalcemia in hypoparathyroidism, with varying effects on hypercalciuria. However, little is known about its ability to decrease the renal comorbidities of hypoparathyroidism: nephrocalcinosis (NC), nephrolithiasis (NL), and renal insufficiency. Urinary citrate (Ucit) promotes the solubility of urinary calcium (UCa); hypocitraturia is a risk factor for NC/NL. Read More

Curr Urol Rep 2018 Apr 16;19(6):41. Epub 2018 Apr 16.

Department of Urology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 3258 Medical Foundation Centennial Building, Madison, WI, 53705-2281, USA.

Purpose Of Review: Urinary risk factors, such as hypercalciuria, hypocitraturia, and hyperoxaluria, either in combination or alone, are associated with calcium stones. Dietary habits as well as underlying medical conditions can influence urinary risk factors. Evaluation of the conglomerate of patients' stone risks provides evidence for individualized medical management, an effective and patient-supported approach to prevention. Read More

Pediatr Nephrol 2018 Jul 28;33(7):1173-1181. Epub 2018 Mar 28.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10150, Thailand.

Background: Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population. Read More

Nutr Clin Pract 2018 Dec 23;33(6):897-901. Epub 2018 Mar 23.

Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Short bowel syndrome (SBS) can lead to many complications related to the condition and its therapy. We describe 2 children with SBS who we believe are the second and third patients documented to have experienced both D-lactic acidosis and urolithiasis. We review aspects of these SBS complications and recent findings on the microbiome of patients with SBS that may predispose to these complications. Read More

Iran J Kidney Dis 2018 01;12(1):22-26

Department of Nephrology, Lorestan University of Medical Sciences, Khorramabad, Iran.

Introduction: Nephrolithiasis is one of the most common urinary tract diseases. After the first episode of urinary calculus, the risk of recurrence is nearly 40% to 50% at 5 years. Nephrolithiasis is a systemic disease that is associated with some metabolic disorders. Read More

Urol Ann 2018 Jan-Mar;10(1):94-99

Department of Urology and Renal Transplantation, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.

Aim: The aim of the study is to identify the prevalence of metabolic abnormalities in children with urolithiasis.

Materials And Methods: This is a prospective study; all children below 15 years who are found to have urolithiasis were prospectively evaluated with relevant history, clinical examination, and urine and serum testing. Metabolic workup includes complete urine examination, urine culture and sensitivity, and 24-h urinary analysis (lithorisk profile). Read More

Int Braz J Urol 2018 Jul-Aug;44(4):680-687

Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Obesity is a worldwide challenging health problem. Weight loss through medical management of obesity has not always been successful, thus, giving rise to the need for surgical intervention. Bariatric surgery has been shown to be helpful for morbidly obese patients. Read More

J Nephrol 2018 Apr 24;31(2):189-196. Epub 2018 Jan 24.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8885, USA.

Hyperuricosuric calcium urolithiasis is a condition of mixed calcium oxalate stones characterized by hyperuricosuria either in isolation or in conjunction with other risk factors for calcium oxalate stones such as hypercalciuria, hyperoxaluria, and hypocitraturia. There are three proposed physicochemical models of pathogenesis where urate in its crystalline phase via heterogeneous nucleation, in its colloidal phase via removal of crystallization inhibitors, and in solution via precipitation crystallization, can all increase propensity to calcium oxalate precipitation. Regardless of the model, the phenomenologic observation of urate increasing calcium oxalate precipitation appears solid. Read More

J Urol 2018 Feb 8;199(2):336. Epub 2017 Nov 8.

Urol J 2018 05 3;15(3):87-91. Epub 2018 May 3.

Ivanovo State Medical Academy, 153012 Ivanovo, Russian Federation.

Purpose: The paper focuses on the relationship of risk factors and metabolic disorders with mineralogical composition of calculi, age and gender of calcium oxalate stone formers.

Materials And Methods: Stone mineralogical composition, 24 hour biochemistry and pH-profile of urine were examined for sixty four stone formers using powder X-ray diffraction, spectrophotometric and potentiometric techniques.

Results: The analysis indicated that 44 % of calculi were composed of pure calcium oxalate monohydrate, whereas other 56 % contained both monohydrate and dihydrate or usually their mixtures with hydroxyl apatite. Read More

Einstein (Sao Paulo) 2017 Oct-Dec;15(4):452-456. Epub 2017 Dec 18.

Centro Universitário Faculdade Assis Gurgacz, Cascavel, PR, Brazil.

Objective: To evaluate the prevalence of metabolic disorders associated with nephrolithiasis in a female population.

Methods: A retrospective study on 1,737 patients with evidence of recent formation of renal stones, being 54% females. The laboratory investigation consisted of at least two samples of blood and 24-hour urine to assess calcium, uric acid, citrate and creatinine levels, qualitative cystinuria, urinary pH following fasting and 12-hour water restriction, urine culture, serum creatinine and parathyroid hormone. Read More

BMC Nephrol 2017 Dec 4;18(1):353. Epub 2017 Dec 4.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1 Kusunokicho, Chuo, Kobe, Hyogo, 6500017, Japan.

Background: Autosomal recessive distal renal tubular acidosis (dRTA) is a rare hereditary disease caused by pathogenic variants in the ATP6V0A4 gene or ATP6V1B1 gene, and characterized by hyperchloremic metabolic acidosis with normal anion gap, hypokalemia, hypercalciuria, hypocitraturia and nephrocalcinosis. Although several intronic nucleotide variants in these genes have been detected, all of them fell in the apparent splice consensus sequence. In general, transcriptional analysis is necessary to determine the effect on function of the novel intronic variants located out of splicing consensus sequences. Read More

J Urol 2017 Dec 19;198(6):1203-1204. Epub 2017 Sep 19.

BJU Int 2018 02 28;121(2):281-288. Epub 2017 Nov 28.

Section of Endourology, Division of Urology, Hospital das Clínicas, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Objectives: To characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis.

Patients And Methods: We analysed the prospectively collected charts of patients treated at our stone clinic between January 2001 and January 2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands was assessed. Read More

J Endourol 2017 12;31(12):1335-1341

1 Department of Urology, University of Florida College of Medicine , Gainesville, Florida.

Introduction And Objective: Despite guidelines, routine 24-hour urine testing is completed in <10% of high-risk, recurrent stone formers. Using surrogates for metabolic testing, such as key patient characteristics, could obviate the cost and burden of this test while providing information needed for proper stone prevention counseling.

Methods: We performed a retrospective study of 392 consecutive patients from 2007 to 2014 with ≥2 lifetime stone episodes, >70% calcium oxalate by mineral analysis, and ≥1 24-hour urine collection. Read More

Arch Esp Urol 2017 Oct;70(8):725-731

Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Asunción. Paraguay.

Objective: To determine the lithogenic risk index and its evolution after treatment of paraguayan lithiasic patients.

Methods: This experimental study of temporal series included 28 lithiasic patients of both sexes that attended to the Instituto de Prevision Social in 2012. Basal evaluation included metabolic study and urinary saturation indexes determined by EQUIL software. Read More

Urologiia 2017 Sep(4):22-26

United Physico-Chemical Center of Solutions, G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences and Ivanovo State University of Chemical Technology, Ivanovo, Russia.

Aim: To identify the most likely metabolic disturbances and risk factors for stone formation in a group of patients with calcium oxalate urolithiasis, and to establish the relationship between the mineralogical composition of calculi and impaired excretion of inhibitors and promoters of stone formation.

Materials And Methods: Fifty patients with calcium oxalate urolithiasis were tested using a complex of physicochemical methods. Patients assessment included evaluation of quantitative mineralogical composition of calculi, daily urine pH profile and daily urinary excretion of urates, calcium, magnesium, oxalate, phosphate and citrate ions. Read More

Minerva Urol Nefrol 2018 Feb 7;70(1):87-94. Epub 2017 Sep 7.

Department of Urology, University of Rome Tor Vergata, Rome, Italy.

Background: Nephrolithiasis is a common condition with several studies documenting an increased prevalence over the past four decades. EAU and AUA guidelines recommend 24-hour urine metabolic evaluation in high-risk stone formers. Aim of this study is to retrospectively evaluate the first three years of experience with LithoTest® (Biohealth Italia Srl, Turin, Italy) through the analysis of demographic, clinical and biochemical data collected from a large cohort of patients with kidney stones. Read More

J Pediatr Urol 2017 Aug 4;13(4):357.e1-357.e7. Epub 2017 Aug 4.

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

Introduction: Hypercalciuria, hypocitraturia and cystinuria are the most common underlying metabolic stone abnormalities in children. The present study compared stone growth patterns, stone burden, and the risk of stone-related surgery among these underlying metabolic conditions.

Methods: A retrospective cohort of 356 children with renal stones, followed from 2000 to 2015, was studied. Read More

J Endourol 2017 09;31(9):962

Department of Urology, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.

G Ital Nefrol 2017 Aug 1;34(4):51-60. Epub 2017 Aug 1.

Fondazione Scientifica Ospedale Mauriziano Onlus-Torino.

Citrate is a tricarboxylic acid and an intermediate metabolite of Krebs cycle. It contributes to oxidative metabolism of both kidney and liver. Alkaline sodium or potassium salts have the potential to increase alkaline reserve. Read More

J Pediatr Urol 2017 Dec 24;13(6):629.e1-629.e5. Epub 2017 Jun 24.

Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, PR China.

Introduction: Cystine stone is the only clinical manifestation in patients with cystinuria, which is an autosomal recessive inheritable disease. However, clinical and genetic data vary among patients in different countries.

Objective: To investigate the characteristics of Chinese pediatric cystine stone patients. Read More

Clin Exp Nephrol 2018 Feb 26;22(1):133-141. Epub 2017 Jun 26.

Division of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Koc University, Davutpaşa cad no: 4 Topkapı, 34010, Istanbul, Turkey.

Background: To investigate relationships among urinary biomarkers [kidney injury molecule-1 (KIM-1), N-acetyl-β-glucosaminidase (NAG)], neutrophil gelatinase-associated lipocalin (NGAL) levels and renal tubular injury in childhood urolithiasis.

Methods: Seventy children [36 girls, mean age: 7.3 ± 5. Read More

Urolithiasis 2018 Apr 16;46(2):137-147. Epub 2017 Jun 16.

Non-Communicable Diseases Research Unit (NCDRU), South African Medical Research Council, Cape Town, South Africa.

Fatty acid (FA) composition of phospholipids in plasma and red blood cells (RBC) can influence calciuria, oxaluria and renal stone formation. In this regard, the ratio of arachidonic acid (AA) and its precursor linoleic acid (LA) appears to be important. Administration of γ-linolenic acid (GLA) has been shown to increase the concentration of dihomo-gamma linoleic acid (DGLA) relative to AA indicating that it may attenuate biosynthesis of the latter. Read More

J Endourol 2017 09 7;31(9):956-961. Epub 2017 Jul 7.

1 Department of Urology, Glickman Urology and Kidney Institute , Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: Vascular calcifications are associated with nephrolithiasis. Although studies have demonstrated correlations with vascular disease and calcium stones in kidney stone formers (KSF), an etiologic link has remained elusive. As a noncontrast CT (NCCT) scan is typically part of a stone evaluation, our objective was to evaluate the association of NCCT-based assessment of abdominal aortic calcifications (AACs) with 24-hour urine parameters and stone composition. Read More

Iran J Kidney Dis 2017 May;11(3):209-216

UO Nefrologia e Dialisi Ospedale "G Di Cristina" ARNAS Palermo, Palermo, Italy.

Introduction: Prevalence of urinary calculi in children has been increasing in the past years. We performed an analysis of the chemical composition of stones formers of the pediatric population in our geographical area over the years 2005 to 2013.

Materials And Methods: Fourier transform infrared spectroscopy was employed for the determination of the calculus composition of a group of Sicilian children, and metabolic studies were performed to formulate the correct diagnosis and establish therapy. Read More

PLoS One 2017 19;12(5):e0177329. Epub 2017 May 19.

Université Paris Descartes, Faculté de Médecine, Paris, France.

Background And Objectives: Hypocitraturia has been associated with metabolic acidosis and mineral disorders. The aim of this study was to investigate the occurrence of urinary acidification defects underlying hypocitraturia.

Materials And Methods: This retrospective observational study included 67 patients (32 men), aged 40. Read More

J Endourol 2017 08;31(8):806-811

1 Department of Urology, College of Medicine, Chungbuk National University , Cheongju, South Korea .

Purpose: The aim of this study was to assess the metabolic characteristics and risks of stone recurrence in young adult stone patients in Korea.

Patients And Methods: The medical records of 1532 patients presenting with renal or ureteric stones at our stone clinic between 1994 and 2015 were retrospectively reviewed. Patients were grouped according to age (young adult, 18-29 years; intermediate onset, 30-59 years; old age, ≥60 years) at first presentation, and measurements of clinicometabolic characteristics and risks of stone recurrence were compared. Read More

Bariatr Surg Pract Patient Care 2017 Mar;12(1):3-9

Department of Urology, University of Florida, Gainesville, Florida.

Obesity is rampant across the spectrum of age, gender, and race in the Unites States. Paralleling this epidemic, kidney stone prevalence is also rising, affecting nearly 1 in 11 individuals. Bariatric surgical procedures, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), are the most effective weight loss options for morbidly obese or severely obese individuals with comorbidities. Read More

Isr Med Assoc J 2016 Dec;18(12):725-728

Department of Urology, Sheba Medical Center, Tel Hashomer, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The prevalence and etiology of nephrolithiasis vary, depending on geography, gender and ethnicity.

Objectives: To analyze the demographic data of return nephrolithiasis patients in a tertiary care center.

Methods: We retrospectively reviewed our prospective registry database of return patients seen at our outpatient clinic for nephrolithiasis. Read More

J Urol 2017 Aug 30;198(2):416-421. Epub 2017 Mar 30.

Children's Hospital Medical Center, Cincinnati, Ohio; Laboratory Corporation of America® Holdings, Chicago, Illinois (JA).

Purpose: The prevalence of urinary stone disease is increasing in children. We previously reported a high rate of urinary metabolic abnormalities, including hypercalciuria and hypocitraturia, in stone forming children. In this study we determined whether calcium-to-citrate ratio could help predict those at risk for recurrent stone formation. Read More