Jpn J Radiol 2017 Jun 21. Epub 2017 Jun 21.

Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, 1197-1 Yasashicho, Asahi-ku, Yokohama, Kanagawa, 241-0811, Japan.

Primary hyperparathyroidism (pHPT) causes hypercalcemia. The treatment for pHPT is surgical dissection of the hyperfunctioning parathyroid gland. Lower rates of hypocalcemia and recurrent laryngeal nerve injury imply that minimally invasive parathyroidectomy (MIP) is safer than bilateral neck resection. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):416-420

Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Beijing 100021, China.

Objective: To analyse the postoperative metastasis or recurrence of cervical lymph nodes in individual neck levels for papillary thyroid carcinoma and to evaluate the outcomes and complications of re-surgery. Methods: A retrospective cohort study of 259 patients who underwent lymph node dissection for PTC relapse from January 2010 to June 2011. Lymph node metastases in each of neck levels were detected, postoperative complications were evaluated, and the patients were followed up with examining thyroglobulin levels to assess the therapeutic effect. Read More

Int J Surg 2017 Jun 17. Epub 2017 Jun 17.

Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China.

Background: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT. Read More

Tohoku J Exp Med 2017 ;242(2):115-120

Department of Orthopaedic Surgery, Shinshu University School of Medicine.

Osteogenesis imperfecta (OI) is an inherited bone disorder that causes fractures due to impaired production of collagen type I. In recent years, denosumab, a human monoclonal antibody against receptor activator of nuclear factor κB ligand (RANKL), has become widely used as an anti-osteoclastic agent for osteoporosis. This study investigated osteoporotic cases of OI to examine effects of denosumab on bone fragility. Read More

Neuromuscul Disord 2017 May 4. Epub 2017 May 4.

Muscle Immunoanalysis Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4AZ, UK. Electronic address:

Dominant mutations in STIM1 are a cause of three allelic conditions: tubular aggregate myopathy, Stormorken syndrome (a complex phenotype including myopathy, hyposplenism, hypocalcaemia and bleeding diathesis), and a platelet dysfunction disorder, York platelet syndrome. Previous reports have suggested a genotype-phenotype correlation with mutations in the N-terminal EF-hand domain associated with tubular aggregate myopathy, and a common mutation at p.R304W in a coiled coil domain associated with Stormorken syndrome. Read More

Nephrology (Carlton) 2017 Jul;22(7):572-573

Department of Internal Medicine, Fukuoka Dental College, Fukuoka, Japan.

Nephrology (Carlton) 2017 Jun 15. Epub 2017 Jun 15.

The Canberra Hospital Renal Unit.

Aim: To assess the efficacy, safety and calcium balance of a membrane based regional citrate anticoagulation plasma exchange protocol METHODS: This was an observational, prospective, single center study of membrane separation plasma exchange using regional citrate anticoagulation. It was performed using a fixed dose pre-filter citrate infusion that was based on the plasma flow rate. Patients received a post filter calcium infusion which was modified during treatment based on systemic ionized calcium monitoring. Read More

Scand J Clin Lab Invest 2017 Jun 14:1-6. Epub 2017 Jun 14.

a Department of Medical Sciences , Clinical Chemistry, Uppsala University , Uppsala , Sweden.

Background: There is a longstanding controversy as to whether plasma measurements of total calcium should be adjusted for albumin concentration, and if so which formulas are the most appropriate.

Methods: Ionised calcium, total calcium and albumin results, analysed at the same time at Uppsala University Hospital Laboratory between February 2005 and June 2013, were retrieved from a laboratory information system. The dataset included results from 20,003 patients. Read More

Clin Ter 2017 May-Jun;168(3):e194-e198

Department of Surgery and Medical and Surgical Specialties, General And Breast Surgery Unit, University of Catania.

Background: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. Read More

J Matern Fetal Neonatal Med 2017 Jun 14:1-5. Epub 2017 Jun 14.

b Büyük Anadolu Hastanesi , Samsun , Turkey.

Objective: Vitamin D has many important functions in our body. Especially in intrauterine and early infancy periods, Vitamin D plays a major role in bone development, growth, and the maturation of tissues such as lung and brain. Fetus is dependent on the mother in terms of Vitamin D and maternal Vitamin D deficiency results in a Vitamin D deficient newborn. Read More

Int Urol Nephrol 2017 Jun 12. Epub 2017 Jun 12.

Department of Medicine, Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combination undermines their homeostatic capability. Hyponatremia, hypokalemia, hyperkalemia, hypocalcemia, metabolic acidosis, respiratory, and metabolic alkalosis are the main internal milieu alterations in this group. Read More

J Steroid Biochem Mol Biol 2017 Jun 9. Epub 2017 Jun 9.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). These actions include orchestration of mineral homeostasis which is coordinated by the kidney, intestine, bone and parathyroid gland wherein the VDR transcriptionally regulates expression of the genes involved in this complex process. Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis. Read More

Schweiz Arch Tierheilkd 2017 Jun;159(6):335-343

Wiederkäuerklinik, Vetsuisse-Fakultät, Universität Bern.

Introduction: The aim of this study was to obtain the diagnostic, therapeutic and prophylactic approach among Swiss veterinary practitioners in cows with parturient hypocalcemia. All members of the Association for Ruminant Health were contacted per e-mail. The survey was completed by 108 (28%) of 393 that were contacted. Read More

Turk J Surg 2017 1;33(1):14-17. Epub 2017 Mar 1.

General Practitoner, Boatni Health Center, Benghazi, Libya.

Objective: Reoperative thyroid surgery is rare and has a high complication rate. This retrospective cohort study was performed to determine the recurrent laryngeal nerve injury and hypoparathyroidism rates after reoperative thyroid surgery in two university hospitals in Benghazi, Libya.

Material And Methods: All consecutive patients who underwent reoperative thyroid surgery between January 2002 and July 2014 were included retrospectively. Read More

Mymensingh Med J 2017 Apr;26(2):335-340

Dr Sayeed Bin Sharif, Resident, MS General Surgery, Sir Slimullah Medical College & Mitford Hospital, Mitford, Dhaka, Bangladesh.

Postoperative transient hypocalcaemia is a common squeal after total thyroidectomy usually due to parathyroid insufficiency. Objective of this study is to find out the optimum cut-off value of parathyroid hormone (PTH) level in early postoperative period as a best predictor for hypocalcaemia. This prospective observational study was carried out from July 2013 to July 2014 in the Department of Surgery Sir Salimullah Medical College & Mitford Hospital (SSMC&MH), in collaboration with department of Otolaryngology SSMC&MH, department of Otolaryngology Bangabandhu Sheikh Mujib Medical University (BSMMU) and department of Otolaryngology Dhaka Medical College & Hospital (DMC&H), Dhaka. Read More

J Clin Res Pediatr Endocrinol 2017 Jun 7. Epub 2017 Jun 7.

Objective: Vitamin D-dependent rickets type IA (VDDR-IA) is a rare autosomal recessive disorder characterized by the early onset of severe rickets. The objectives of this study were twofold: 1) to analyze the clinical characteristics and therapy of two patients with VDDR-IA from two separate Chinese family, and 2) investigate the CYP27B1 gene in two large pedigrees.

Methods: Medical history, clinical manifestations, physical examination, radiological findings and laboratory data were analyzed from two patients with VDDR-IA. Read More

Am J Emerg Med 2017 May 26. Epub 2017 May 26.

Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States. Electronic address:

Tumor lysis syndrome (TLS) is a potentially fatal condition defined both by laboratory and clinical criteria. It is caused by the catabolism of tumor cells which leads to considerable release and elevated levels of phosphate, potassium and uric acid in the bloodstream. These electrolyte derangements predispose patients to renal tubule uric acid precipitation, acute kidney injury, arrhythmias, neuromuscular irritability and even seizures. Read More

J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):672-675

Department of Hepatology & Nutrition, Children Hospital & Institute of child health, Lahore, Pakistan.

Objective: Celiac crisis is a serious life threatening complication of celiac disease characterized by profuse diarrhoea, severe dehydration and metabolic disturbances leading to neuromuscular weakness, cardiac arrhythmias and sudden death. It has been described as rare condition and not well documented in the literature. To improve awareness and facilitate diagnosis of this condition, we studied risk factors, pattern of presentation and management plans of celiac crisis. Read More

Int J Surg 2017 May 31;43:112-118. Epub 2017 May 31.

Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China.

Objective: This study was intended to demonstrate the feasibility and efficacy of purge parathyroidectomy (PPTX) for patients with secondary hyperparathyroidism (SHPT).

Methods: The "seed, environment, and soil" medical hypothesis was first raised, following review of the literatures, to demonstrate the possible causes of persistence or recurrence of SHPT after parathyroidectomy. Subsequently, the novel surgical strategy of PPTX was proposed, which involves comprehensive resection of the fibro-fatty tissues, including visible or invisible parathyroid, within the region surrounded by the thyroid cartilage, bilateral carotid artery sheath, and the brachiocephalic artery. Read More

Endocrinology 2017 Jun 2. Epub 2017 Jun 2.

Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, UK.

The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that plays a pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in pancreatic islet α- and β-cells that secrete glucagon and insulin, respectively. To determine whether the CaSR may influence systemic glucose homeostasis, we characterized a mouse model with a germline gain-of-function CaSR mutation, Leu723Gln, referred to as Nuclear flecks (Nuf). Read More

Continuum (Minneap Minn) 2017 Jun;23(3, Neurology of Systemic Disease):778-801

Purpose Of Review: This article provides an overview of endocrine emergencies with potentially devastating neurologic manifestations that may be fatal if left untreated. Pituitary apoplexy, adrenal crisis, myxedema coma, thyroid storm, acute hypercalcemia and hypocalcemia, hyperglycemic emergencies (diabetic ketoacidosis and hyperglycemic hyperosmolar state), and acute hypoglycemia are discussed, with an emphasis on identifying the signs and symptoms as well as diagnosing and managing these clinical entities.

Recent Findings: To identify the optimal management of endocrine emergencies, using formal clinical diagnostic criteria and grading scales such as those recently proposed for pituitary apoplexy will be beneficial in future prospective studies. Read More

Malawi Med J 2017 Mar;29(1):55-56

Department of Surgery, North Devon District Hospital, Barnstaple, United Kingdom.

Background: The aim of this study was to examine biochemical investigations not routinely performed prior to emergency laparotomy in patients at Queen Elizabeth Central Hospital, a low-resource public hospital in Blantyre, Malawi.

Methods: A prospective cross-sectional study of adults (N = 15) needing emergency laparotomy over a 4-week period were studied at Queen Elizabeth Central Hospital. Biochemical investigations, not routinely performed for economic reasons, were performed preoperatively; these included sodium, potassium, chloride, carbon dioxide, urea, and calcium levels. Read More

Intern Med 2017 1;56(11):1345-1349. Epub 2017 Jun 1.

Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Japan.

Paraneoplastic syndromes are generally defined as clinical disorders associated with malignant diseases, and hypocalcemia associated with cancer is a rare condition. A woman in her 60s was referred to our hospital for the further examination of massive ascites due to carcinoma of unknown primary origin. She complained of numbness around her lips, and marked hypocalcemia of 5. Read More

Laryngoscope 2017 May 31. Epub 2017 May 31.

Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.

Objective: To assess the effect of truncal ligation of the inferior thyroid artery in comparison with ligation of secondary branches as a risk factor for postoperative hypocalcemia.

Data Sources: A search was conducted using the Medical Subject Headings and free-text terms "thyroid*" and "truncal ligation*" in PubMed Central, PubMed, Embase, and Latin American and Caribbean Health Sciences Literature databases for trials published between January 1985 and October 2016. A Google search with the same terms, and a "snowball" approach was designed to retrieve the largest number of articles. Read More

Pragmat Obs Res 2017 16;8:57-67. Epub 2017 May 16.

Department of Oncology and Metabolism.

Background: Differentiated thyroid cancer (DTC) occurs in relatively young patients and is associated with a good prognosis and long survival. The management of this disease involves thyroidectomy, radioiodine therapy, and long-term thyroid-stimulating hormone suppression therapy (THST). The long-term effects of the treatment and the interaction between subclinical hyperthyroidism and long-term hypoparathyroidism are poorly understood. Read More

Exp Toxicol Pathol 2017 May 25. Epub 2017 May 25.

Zhejiang Cancer Hospital, Hangzhou 310000, Zhejiang, China. Electronic address:

Background: Medullary thyroid carcinoma (MTC), defined as a malignant tumour with C-cell differentiation, is of neuroendocrine origin and is characterized by the synthesis and secretion of calcitonin (CT). MTC without CT secretion has been reported on rare occasions. The purpose of this study was to evaluate the histological, immunohistochemical, and molecular pathologic features as well as the clinical significance of non-secretory MTC (NCR-MTC). Read More

Clin J Am Soc Nephrol 2017 Jun 26;12(6):965-973. Epub 2017 May 26.

Division of Nephrology, McMaster University, Hamilton, Ontario, Canada.

Background And Objectives: Hyperphosphatemia is common among recipients of maintenance dialysis and is associated with a higher risk of mortality and cardiovascular events. A large randomized trial is needed to determine whether lowering phosphate concentrations with binders improves patient-important outcomes. To inform such an effort we conducted a pilot randomized controlled trial. Read More

Ther Clin Risk Manag 2017 15;13:635-641. Epub 2017 May 15.

Biostatistics Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Background And Aim: The optimal approach to detect and treat symptomatic hypocalcemia (SxH) after thyroidectomy is still uncertain. In our retrospective study, we sought to set a standardized postoperative management protocol on the basis of relative change of parathyroid hormone (PTH) and absolute value of postoperative day 1 (POD1) PTH.

Methods: Patients who underwent thyroidectomy were identified retrospectively in our prospective database. Read More

BMC Surg 2017 May 25;17(1):62. Epub 2017 May 25.

Department of Thyroid & Parathyroid surgery, West China Hospital, Sichuan University, Guoxue Alley 37#, Chengdu, Sichuan, 610041, People's Republic of China.

Background: To investigate the role of magnesium in biochemical and symptomatic hypocalcemia, a retrospective study was conducted.

Methods: Less-than-total thyroidectomy patients were excluded from the final analysis. Identified the risk factors of biochemical and symptomatic hypocalcemia, and investigated the correlation by logistic regression and correlation test respectively. Read More

J Clin Immunol 2017 May 24. Epub 2017 May 24.

The 22q and You Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Purpose: Chromosome 22q11.2 deletion syndrome (22q11.2DS), the most common cause of DiGeorge syndrome, is quite variable. Read More

Oncotarget 2017 May 8. Epub 2017 May 8.

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: There appears to be a lack of consensus whether preoperative vitamin D deficiency (VDD) increases the risk of postoperative hypocalcemia and decreases the accuracy of postoperative parathyroid hormone (PTH) in predicting hypocalcemia in thyroid cancer patients undergoing total thyroidectomy (TT) plus central compartment neck dissection (CCND). This study aims to address these issues.

Method: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and April 2016 in a tertiary referral hospital. Read More

Pol Przegl Chir 2017 Apr;89(2):26-30

3 University Reaserch Hospital named after professor Kornel Gibiński of the Medical Univeristy of Silesia in Katowice, Ward of Alimentary Canal Surgery, Ward supervisor prof. Paweł lampe.

Introduction: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. Read More

J Intensive Care Med 2017 Jan 1:885066617706650. Epub 2017 Jan 1.

3 Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Electrolyte disturbances are frequently encountered in critically ill oncology patients. Hyponatremia and hypernatremia as well as hypocalcemia and hypercalcemia are among the most commonly encountered electrolyte abnormalities. In the intensive care unit, management of critical electrolyte disturbances is focused on initial evaluation and immediate treatment plan to prevent severe complications. Read More

J Matern Fetal Neonatal Med 2017 Jun 9:1-6. Epub 2017 Jun 9.

a Department of Pediatrics , Saitama Medical Center Jichi Medical University , Saitama , Japan.

Purpose: To investigate the association between glycated albumin (GA) in diabetic mothers and complications in their children, and to determine GA cutoff values for predicting complications in infants.

Materials And Methods: This hospital-based case-control study involved 71 Japanese diabetic mothers and their children. Mean GA values were compared between mothers of infants with and without complications, and relationship with number of complications was analyzed by Pearson's correlation. Read More

Harefuah 2017 Jan;156(1):14-18

Department of Surgery, Hillel Yaffe Medical Center, Hadera and the Technion-Israel Institute of Technology, Haifa.

Introduction: Minimally Invasive Parathyroidectomy (MIP) has become the treatment of choice of Primary Hyperparathyroidism (PHPT) caused by an adenoma. In the present investigation we describe our experience with MIP performed under local anesthesia.

Methods: MIP was performed on 454 of 496 patients (91. Read More

Langenbecks Arch Surg 2017 May 20. Epub 2017 May 20.

Department of Surgical Science, Azienda Ospedaliero-Universitaria, Presidio Policlinico di Monserrato, University of Cagliari, Blocco G, SS 554 km 4,500, 09042, Monserrato, CA, Italy.

Purpose: The aim of this randomized-controlled trial was to validate the results of a previous prospective single-cohort observational study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (iPTH) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy.

Methods: From January 2014 to January 2015, 150 patients underwent total thyroidectomy in our department and were randomized into two groups. The experimental group was submitted to iPTH assay 6 h after surgery while the control group was submitted to a daily assay of serum calcium and phosphorus. Read More

Surg Endosc 2017 May 18. Epub 2017 May 18.

Department of Otolaryngology Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seochogu, Seoul, 06591, Republic of Korea.

Background: A transoral approach has been experimentally introduced to the field of thyroid surgery and several groups in Asia have recently used the technique to treat patients. We performed transoral endoscopic thyroidectomies on patients with thyroid cancer or a benign tumor.

Methods: We reviewed the medical records of patients who underwent transoral endoscopic thyroid surgery between July 2016 and January 2017. Read More

J Hum Genet 2017 May 18. Epub 2017 May 18.

Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan.

Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder of mitochondrial fatty-acid oxidation. Isolated long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is often reported in Caucasian countries due to a common mutation. However, the molecular and clinical basis of complete TFP deficiency has not been extensively reported. Read More

BMJ Case Rep 2017 May 16;2017. Epub 2017 May 16.

National and Kapodistrian University of Athens - Faculty of Medicine, , Athens, Greece.

Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with (153)Sm. Read More

J Clin Diagn Res 2017 Mar 1;11(3):UC01-UC03. Epub 2017 Mar 1.

Postgraduate Student, Department of Anaesthesiology, Critical Care and Pain Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Introduction: Hypocalcaemia is very much prevalent in critically ill patients yet very less is known about its association with severity of illness. Acute Physiology and Chronic Health Evaluation (APACHE) and Sequential Organ Failure Assessment (SOFA) are two commonly used and validated scoring tool used to assess the severity of illness in critically ill patients.

Aim: To analyze the relation of on admission hypocalcaemia with severity of illness as measured by APACHE-II and SOFA scores. Read More

CEN Case Rep 2017 May 27;6(1):111-114. Epub 2017 Feb 27.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki-shi, Kanagawa, 216-8511, Japan.

The efficacy and safety of denosumab for the treatment of immobilization-related hypercalcemia in end-stage renal disease remain uncertain. We describe the case of a hemodialysis patient with immobilization-related hypercalcemia who was successfully treated with denosumab. A 79-year-old man admitted for hemodialysis after sustaining an acute kidney injury developed immobilization-related hypercalcemia due to the impairment resulting from an acute myocardial infarction, acute heart failure, and catheter-related bloodstream infection. Read More

J Cancer Res Ther 2017 Jan-Mar;13(1):102-106

Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Extent of central compartment neck dissection (CCND) in thyroid cancers has been a debate because of associated morbidity. There have been attempts to reduce the extent of surgery in an attempt to decrease morbidity.

Patients And Methods: We analyzed the morbidity of CCND from our prospectively maintained surgical morbidity database. Read More

Ther Apher Dial 2017 May 15. Epub 2017 May 15.

First Department of Internal Medicine, Nara Medical University, Kashihara, Japan.

Technique failure remains a frequent cause of peritoneal dialysis (PD) withdrawal. Many post-commencement predictors of PD technique failure have been identified, while predialysis predictors have remained unclear. The aim of this study was to identify predialysis indices for technique failure in PD patients. Read More

Aust Prescr 2017 Apr 3;40(2):79-80. Epub 2017 Apr 3.

School of Medicine, University of Queensland, Brisbane.

Child Neurol Open 2016 Jan-Dec;3:2329048X16674834. Epub 2016 Oct 27.

Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Objective: Childhood seizures have various nonneurological etiologies. The patient's magnesium levels should be measured when evaluating afebrile seizures. The purpose of the current case series is to describe a systematic approach for diagnosing hypomagnesemia using 3 recent patient cases. Read More

J Dairy Sci 2017 Jul 10;100(7):5805-5823. Epub 2017 May 10.

Department of Animal Sciences, University of Florida, Gainesville 32611; DH Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville 32611. Electronic address:

Our objectives were to determine the effects of an injectable formulation of calcitriol on mineral metabolism and immune function in postpartum Holstein cows that received an acidogenic diet prepartum to minimize hypocalcemia. In experiment 1, cows within 6 h of calving received calcitriol (0, 200, or 300 μg) to determine the dose needed to increase plasma concentrations of Ca; 300 μg was sufficient to sustain Ca for at least 3 d. In experiment 2, multiparous cows were assigned randomly to receive only vehicle (control, n = 25) or 300 μg of calcitriol (n = 25) subcutaneously within the first 6 h after calving. Read More

Am J Kidney Dis 2017 May 9. Epub 2017 May 9.

Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Bone deformities and fractures are common consequences of renal osteodystrophy in the dialysis population. Persistent hypophosphatemia may be observed with more frequent home hemodialysis regimens, but the specific effects on the skeleton are unknown. We present a patient with end-stage renal disease treated with frequent home hemodialysis who developed severe bone pain and multiple fractures, including a hip fracture and a tibia-fibula fracture complicated by nonunion, rendering her nonambulatory and wheelchair bound for more than a year. Read More

PLoS Negl Trop Dis 2017 May 11;11(5):e0005603. Epub 2017 May 11.

Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Background: Severely malnourished children aged under five years requiring hospital admission for diarrheal illness frequently develop ileus during hospitalization with often fatal outcomes. However, there is no data on risk factors and outcome of ileus in such children. We intended to evaluate predictive factors for ileus during hospitalization and their outcomes. Read More

Laryngoscope 2017 May 11. Epub 2017 May 11.

Chicago ENT: Advanced Center for Specialty Care, Chicago, Illinois, U.S.A.

Objectives/hypothesis: Evaluate morbidity and mortality rates for patients with different levels of hyperparathyroidism (HPT) undergoing parathyroidectomy (PTX), specifically comparing primary hyperparathyroidism to secondary and tertiary hyperparathyroidism. Assess predictive factors of increased morbidity and mortality.

Study Design: Retrospective national database review. Read More