15,044 results match your criteria Hypocalcemia


Seeing Beyond Our Expectations: The Case of Pediatric Hypocalcemia.

Authors:
Carol L Wagner

J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2019.03.037DOI Listing

Impact of body mass index on post-thyroidectomy morbidity.

Head Neck 2019 Apr 19. Epub 2019 Apr 19.

CHU de Nantes, Clinique de Chirurgie Digestive et Endocrinienne (CCDE), Nantes Cedex 1, France.

Background: The impact of obesity on total thyroidectomy (TT) morbidity (recurrent laryngeal nerve palsy and hypocalcaemia) remains largely unknown.

Methods: In a prospective study (NCT01551914), patients were divided into five groups according to their body mass index (BMI): underweight, normal weight, overweight, obese, and severely obese. Preoperative and postoperative serum calcium was measured. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25773
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http://dx.doi.org/10.1002/hed.25773DOI Listing
April 2019
1 Read

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing
April 2019
1 Read

Assessment of the Early and Late Complication after Thyroidectomy.

Adv Biomed Res 2019 27;8:14. Epub 2019 Feb 27.

General Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The complications in thyroid surgery have been reported variable in literature. The aim of this study was to evaluate the early and late (3 months after surgery) complication rates of thyroidectomy in a cohort of patients undergoing thyroid surgery at two hospitals of Isfahan University of Medical Science, Iran.

Materials And Methods: This study included 204 patients who candidates for thyroidectomy presenting at Medical Educational Centers of Al-Zahra and Kashani hospitals in Isfahan between March 2016 and March 2017. Read More

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http://dx.doi.org/10.4103/abr.abr_3_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425745PMC
February 2019

[Familial hypomagnesaemia with secondary hypocalcaemia as a cause of seizures in children].

Ugeskr Laeger 2019 Apr;181(15)

This case report presents a three-month-old girl, previously healthy, who was admitted to the hospital due to a cyanotic episode during breastfeeding. The episode was initially interpreted as aspiration. She had recurrent generalised seizures, and blood tests revealed hypomagnesaemia and hypocalcaemia. Read More

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April 2019
2 Reads

Preventive Effect of Dexamethasone Therapy on the Transient Hypoparathyroidism through Total Thyroidectomy.

Iran J Otorhinolaryngol 2019 Mar;31(103):73-80

Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: This study aimed to investigate whether pre-operative dexamethasone could ameliorate transient hypoparathyroidism outcome through total thyroidectomy.

Materials And Methods: This randomized clinical trial study was conducted on 128 patients underwent total thyroidectomy from March 2014 to April 2015. Patients were randomly assigned to two groups of experimental receiving 8 mg IV of intravenous dexamethasone (n=45) 45 min before skin incision treatment and control (n=83). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449529PMC
March 2019
1 Read

[Choice and management of anticoagulation during CRRT].

G Ital Nefrol 2019 Apr;36(2)

U.O. Nefrologia Dialisi e Ipertensione, Policlinico S.Orsola-Malpighi, Bologna, Italia.

Continuous renal replacement therapies (CRRT) are widely used in the treatment of acute kidney injury. Several causes, related to the treatment itself or to the patient's condition, determine the coagulation of the extracorporeal circuit. These interruptions (or down-time) have a negative impact on the effectiveness of the treatment in terms of solute clearance and fluid balance. Read More

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April 2019
2 Reads

Resolution of a case of denosumab-related osteonecrosis of the jaw after tooth extraction.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2314-2317

Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain.

Denosumab is an antiresorptive drug that blocks osteoclast maturation, function and survival, improving bone mineral density and reducing the probability of fracture. It has adverse effects and can be the cause of hypocalcemia and osteonecrosis of the jaw. This report describes the case of a 59-year-old woman with hypothyroidism, antecedents of breast cancer, two strokes, and severe bone osteoporosis. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17370DOI Listing
March 2019
1 Read

Early Calcium Supplementation After Total Thyroidectomy Can Prevent Symptomatic Hypocalcemia - Findings from a Retrospective Study.

Gulf J Oncolog 2019 Jan;1(29):60-65

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kannur, Kerala, India.

Introduction: Thyroidectomy for thyroid cancers and central neck dissection are considered as independent predictors of postoperative hypocalcemia. Post-surgical hypocalcemia is the most common and often the most difficult long-term consequence of thyroid surgeries. Management of hypocalcemia is done with calcium supplementation, but there is no consensus on the timing and the amount of calcium supplementation. Read More

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January 2019
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Population-Based Incidence of Potentially Life-Threatening Complications of Hypocalcemia and the Role of Vitamin D Deficiency.

J Pediatr 2019 Apr 3. Epub 2019 Apr 3.

Department of Family Medicine, Mayo Clinic, Rochester, MN. Electronic address:

Objectives: To determine the incidence of potentially life-threatening complications of hypocalcemia in infants and children in Olmsted County, Minnesota; and to determine if vitamin D deficiency contributed to these events and was, at the time of clinical presentation, considered as a possible cause.

Study Design: In this population-based descriptive study, data were abstracted from the Rochester Epidemiology Project, a medical record linkage system covering 95% of patients in Olmsted County, Minnesota. Participants were children aged 0-5 years who resided in Olmsted County between January 1, 1996 and June 30, 2017, and who received diagnoses of seizures, cardiomyopathy, cardiac arrest, respiratory arrest, laryngospasm, and/or tetany. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.02.018DOI Listing

The utilization and challenges of Japan's MID-NET medical information database network in postmarketing drug safety assessments: A summary of pilot pharmacoepidemiological studies.

Pharmacoepidemiol Drug Saf 2019 Apr 3. Epub 2019 Apr 3.

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, 100-0013, Japan.

Purpose: To examine the potential role of Medical Information Database Network (MID-NET ), a newly established Japanese medical information database network, in postmarketing drug safety assessments through the characterization of its advantages and limitations in five pilot studies.

Methods: The pilot studies were designed to address three major objectives in postmarketing drug safety assessments, ie, the examination of actual drug utilization, the impact of safety-related regulatory actions, and drug-associated risks. The five studies were conducted on the following topics: (a) utilization of codeine-containing products and its relationship with respiratory depression, (b) impact of a Dear Healthcare Professional letter on hypocalcemia incidence associated with denosumab (Ranmark ) use, (c) risk of acute myocardial infarction associated with antidiabetic drug use, (d) risk of glucose metabolism disorders associated with atypical antipsychotic drug use, and (e) prospective monitoring of abnormal laboratory test results during new drug prescriptions. Read More

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http://dx.doi.org/10.1002/pds.4777DOI Listing
April 2019
6 Reads

High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases.

J Clin Transl Hepatol 2019 Mar 26;7(1):15-20. Epub 2018 Oct 26.

Multidisciplinary Research Unit (MRU), Madras Medical College, Chennai, Tamil Nadu, India.

Although hypovitaminosis D is common among patients with chronic liver disease (CLD), the data are inconsistent on its prevalence and its relationship with CLD. This study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction, and calcium (Ca), phosphate (PO4) and parathyroid hormone (PTH) levels in CLD. The study included 236 CLD patients attending the Department of Hepatology, Rajiv Gandhi Government General Hospital (Chennai, India). Read More

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http://dx.doi.org/10.14218/JCTH.2018.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441643PMC
March 2019
2 Reads

Routine low-dose calcium supplementation after thyroidectomy does not reduce the rate of symptomatic hypocalcemia: a prospective randomized trial.

Ann Surg Treat Res 2019 Apr 28;96(4):177-184. Epub 2019 Mar 28.

Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea.

Purpose: Routine supplementation of high-dose calcium significantly decreased the risk of postoperative symptomatic hypocalcemia after thyroidectomy. However, there is an ongoing debate about whether the same results can be achieved with low-dose calcium supplementation.

Methods: Patients (n = 138) who underwent total thyroidectomy for thyroid cancer were 1:1 randomly assigned to receive oral supplements of 1,500 mg/day elemental calcium and 1,000 IU/day cholecalciferol for 2 weeks or no supplementation. Read More

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http://dx.doi.org/10.4174/astr.2019.96.4.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444042PMC
April 2019
3 Reads

Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience.

Int J Surg Oncol 2019 28;2019:6109643. Epub 2019 Feb 28.

Sultan Ismail Hospital, Johor Bahru 81100, Malaysia.

Introduction: Therapeutic nodal dissection is still the mainstay of treatment for patients with lymph node metastases in many centres. The local data, however, on the outcome of therapeutic LND remains limited. Hence, this study aims to inform practice by presenting the outcomes of LND for thyroid cancer patients and our experience in a tertiary referral centre. Read More

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http://dx.doi.org/10.1155/2019/6109643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421004PMC
February 2019
1 Read

Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C usage in laparoscopic hyperthermic intraperitoneal chemotherapy.

Int J Hyperthermia 2019 Apr 1:1-6. Epub 2019 Apr 1.

b Department of Surgical Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Background: Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) has been used to treat various peritoneal malignancies. Cisplatin and mitomycin C (MMC) are agents commonly used in these procedures and, individually, each has been associated with acute kidney injury (AKI). There is limited literature on the complications associated with the use of both agents in HIPEC. Read More

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http://dx.doi.org/10.1080/02656736.2019.1597175DOI Listing
April 2019
2 Reads

Pseudohypoparathyroidism and Cardiomyopathy: A Case Report with a New Perspective on the Cardiovascular-Endocrine Axis with Respect to Calcium Homeostasis.

Authors:
Anum Fasih

Eur J Case Rep Intern Med 2019 15;6(2):000993. Epub 2019 Feb 15.

Department of Family Medicine, University of Illinois, College of Medicine, Peoria, IL, USA.

Pseudohypoparathyroidism encompasses a group of heterogeneous disorders defined by targeted organ unresponsiveness to parathyroid hormone (PTH). With an estimated prevalence of approximately 0.79 per 100,000, this is an extremely rare group of genetic disorders. Read More

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http://dx.doi.org/10.12890/2019_000993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432826PMC
February 2019
1 Read

Conservative thyroidectomy for papillary thyroid microcarcinoma.

Am J Otolaryngol 2019 Mar 21. Epub 2019 Mar 21.

Departments of Otorhinolaryngology - Head & Neck Surgery, School of Medicine, Konkuk University, Seoul, Republic of Korea. Electronic address:

Objective: According to American Thyroid Association (ATA) guideline, thyroid lobectomy is recommended for the management of papillary thyroid microcarcinomas (PTMC) with a diameter lesser than 1 cm. However, this procedure is associated with a risk of potential complications such as vocal cord palsy. Thus, we considered the applicability of conservative thyroidectomy, involving partial removal of the thyroid cancer lesion, not the entire ipsilateral thyroid lobe. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.016DOI Listing
March 2019
2 Reads

An Unusual Cause of Metabolic Alkalosis and Hypocalcemia in Childhood.

Clin Chem 2019 Apr;65(4):514-517

Department of Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1373/clinchem.2018.287136DOI Listing
April 2019
1 Read

Hypoparathyroidism After Total Thyroidectomy: Importance of the Intraoperative Management of the Parathyroid Glands.

World J Surg 2019 Mar 27. Epub 2019 Mar 27.

Service of Endocrine and Advanced Laparoscopic Surgery/Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, 14000, Mexico City, Mexico.

Background: Total thyroidectomy is the most common surgical procedure for the treatment of thyroid diseases. Postoperative hypocalcemia/hypoparathyroidism is the most frequent complication after total thyroidectomy. The aim of this study was to evaluate the rate of postoperative hypocalcemia and permanent hypoparathyroidism after total thyroidectomy in order to identify potential risk factors and to evaluate the impact of parathyroid autotransplantation. Read More

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http://dx.doi.org/10.1007/s00268-019-04987-zDOI Listing
March 2019
1 Read

Effects of Supplemental Perioperative Oxygen in Preventing Transient Hypoparathyroidism After Total Thyroidectomy.

Cureus 2018 Oct 11;10(10):e3440. Epub 2018 Oct 11.

Surgery, Holy Family Hospital, Rawalpindi, PAK.

Background Thyroidectomy is one of the most common endocrine procedures performed worldwide. Post-operative hypocalcemia is a troublesome complication of thyroid surgery. Few studies have considered the role of supplemental oxygen in preventing postoperative hypocalcemia in patients undergoing thyroidectomy. Read More

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http://dx.doi.org/10.7759/cureus.3440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433448PMC
October 2018
1 Read

Causes of Deceased Donors Loss before Organ Retrieval.

Tanaffos 2018 Mar;17(3):172-176

Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: When potential brain dead donors are in line-up for organ retrieval, their loss would be such a disaster. The aim of this study was to detect the occurrence of different disorders leading to pre-retrieval donor's cardiac arrest and loss in order to prevent this energy and money wasting challenge.

Materials And Methods: In this observational study, medical records of potential donors from 2001 to 2016 who were lost after transfer to Organ Procurement Unit (OPU) of Masih Daneshvari Hospital and before organ donation were reviewed and weigh of every responsible disorder was tested. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428383PMC
March 2018
1 Read

Search for Novel Mutational Targets in Human Endocrine Diseases.

Endocrinol Metab (Seoul) 2019 Mar;34(1):23-28

Department of Internal Medicine and Laboratory of Genomics and Translational Medicine, Gachon University College of Medicine, Incheon, Korea.

The identification of disease-causing genetic variations is an important goal in the field of genetics. Advancements in genetic technology have changed scientific knowledge and made it possible to determine the basic mechanism and pathogenesis of human disorders rapidly. Many endocrine disorders are caused by genetic variations of a single gene or by mixed genetic factors. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3803/EnM.2019.34
Publisher Site
http://dx.doi.org/10.3803/EnM.2019.34.1.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435846PMC
March 2019
6 Reads

A pediatric case of hypomagnesemia 1 (HOMG1) caused by novel compound heterozygous mutations in .

Hum Genome Var 2019 6;6:13. Epub 2019 Mar 6.

Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Kyoto, Japan.

Hypomagnesemia 1 (HOMG1) is an extremely rare disease with autosomal recessive inheritance that is caused by mutations in the transient receptor potential melastatin 6 gene (). Here, we describe a pediatric HOMG1 case with novel compound heterozygous mutations of (c.1483 C > T [p. Read More

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http://dx.doi.org/10.1038/s41439-019-0043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403217PMC
March 2019
1 Read

The impact of completion thyroidectomy.

Eur J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Otolaryngology, Head and Neck Surgery, NHS Lothian, Edinburgh, UK. Electronic address:

Introduction: The oncological benefit of completion thyroidectomy (CT) following thyroid lobectomy (TL) is presumed to be similar to that of upfront total thyroidectomy(TT), from a patient's perspective the risk and inconvenience of further surgery adds significantly to the impact of the overall treatment. The aim of this study is to assess the impact of CT in terms of the duration of admission and associated complications.

Methods: A study of consecutive patients with DTC identified from prospective MDT records of South-East Scotland from 2009 to 2015. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.018DOI Listing
March 2019
1 Read

Maternal serum uric acid and calcium as predictors of hypertensive disorder of pregnancy: A case control study.

Taiwan J Obstet Gynecol 2019 Mar;58(2):244-250

Department of Physiology, U.P. University of Medical Sciences, House No. 168, Kaveri Kunj, Phase II, Kamla Nagar, Saifai, Etawah, Agra, 282005, Uttar Pradesh, India. Electronic address:

Objectives: Compare serum uric acid and calcium levels among normotensive and hypertensive pregnant women, to compare maternal and perinatal outcomes in two groups.

Materials And Methods: Prospective case control study was conducted after ethical approval in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India, over seven months. Total 220 antenatal women ≥34 weeks of gestation with 110 cases having hypertensive disorder of pregnancy and 110 controls with normal blood pressure were compared for maternal uric acid and calcium levels and maternal, perinatal outcomes. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.014DOI Listing
March 2019
1 Read

Varied Clinical Presentations of Acute Dystonic Reaction Due to Metoclopramide.

Pediatr Emerg Care 2019 Mar 21. Epub 2019 Mar 21.

Pediatric Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.

Objectives: In this article, in light of the literature, we aimed at discussing data obtained from patients in which extrapyramidal adverse effects that are misdiagnosed as varied clinical presentations developed due to metoclopramide, which is frequently prescribed in pediatric emergency services and in family practice centers for its powerful and rapid antiemetic action.

Methods: The files of patients who presented to a pediatric clinic at the research hospital of Mustafa Kemal University between January 2017 and January 2018 and who were diagnosed as having acute dystonic reaction were reviewed retrospectively.

Results: Generalized hypertonicity in 4 patients, abnormal involuntary movements in 2 patients, oculogyric crisis in 2 patients, local hypertonia in the wrist and fingers in 2 patients, spasmodic cervical hypertonicity in 2 patients, and trismus in 1 patient were found. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001800DOI Listing
March 2019
1 Read

Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions.

Pediatr Nephrol 2019 Mar 22. Epub 2019 Mar 22.

Faculty of Medicine, Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Hypomagnesemia with secondary hypocalcemia is a rare autosomal recessive disorder which manifests in early infancy with generalized seizures, other symptoms of neuromuscular irritability, and growth disturbances. Homozygous mutations in the magnesium transporter gene, transient receptor potential melastatin 6 (TRPM6), cause the disease. Here, we present an 8-month-old Turkish boy with a novel mutation of TRPM6. Read More

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http://dx.doi.org/10.1007/s00467-019-04231-9DOI Listing
March 2019
4 Reads

Surgical management of pediatric thyroid disease: Complication rates after thyroidectomy at the Children's Hospital of Philadelphia high-volume Pediatric Thyroid Center.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: Recent studies suggest improved outcomes for children undergoing thyroidectomy at high-volume pediatric surgery centers. We present outcomes after thyroid surgery at a single center and advocate for referral to high-volume centers for multidisciplinary management of these children.

Methods: Medical records were reviewed for all pediatric patients undergoing thyroid surgery at a single institution from 2009 through 2017. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.009DOI Listing
February 2019
1 Read

Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors.

Surgery 2019 Mar 18. Epub 2019 Mar 18.

Northwestern University Feinberg School of Medicine, Department of Surgery, Chicago, IL. Electronic address:

Introduction: Thyroid cancer survivors are a rapidly growing population in the United States. The factors that drive health-related quality of life (HRQOL) in this population have not been well characterized. We hypothesized that more aggressive treatments and greater treatment-related adverse effects would be associated with worse HRQOL scores in thyroid cancer survivors. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.034DOI Listing
March 2019
1 Read

Uterine Involution and Reproductive Performance in Dairy Cows with Metabolic Diseases.

Animals (Basel) 2019 Mar 18;9(3). Epub 2019 Mar 18.

Department of Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508270, Brazil.

The aim of this study was to investigate the effects of metabolic diseases on uterine involution and reproductive performance during the postpartum period. Multiparous Holstein dairy cows ( = 50) were divided into four groups based on whether they were healthy ( = 14), or had lipomobilization ( = 14), hypocalcemia ( = 11), and hyperketonemia ( = 11). Transrectal palpation and transrectal B-Mode sonography were carried out on days 7, 14, 21, 30, 45 and 60 after parturition. Read More

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http://dx.doi.org/10.3390/ani9030093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466423PMC
March 2019
1 Read

US-guided microwave ablation for primary hyperparathyroidism: a safety and efficacy study.

Eur Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Endocrinology and Metabolism/Diabetes Care & Research Center, Nanjing Medical University Affiliated Geriatric Hospital/Jiangsu Province Geriatric Hospital, Jiangsu Province Official Hospital/Jiangsu Province Insititute of Geriatrics, 30 Luojia Road, Nanjing, 210024, Jiangsu, China.

Objectives: To evaluate the safety and efficacy of microwave ablation (MWA) with the assistance of continuous cool saline injection (CCSI) in patients with primary hyperparathyroidism (PHPT).

Methods: Between November 1, 2014, and February 29, 2016, 22 patients with PHPT were enrolled and treated with ultrasound-guided MWA assisted by CCSI. The levels of parathyroid hormone (PTH) and serum calcium were recorded before and after the MWA. Read More

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http://dx.doi.org/10.1007/s00330-019-06078-yDOI Listing
March 2019
4 Reads

Letter to the Editor: "Prediction of hypocalcemia after total thyroidectomy using indocyanine green angiography of parathyroid glands: A simple quantitative scoring system".

Am J Surg 2019 Mar 11. Epub 2019 Mar 11.

Department of Endocrine Surgery, SGPGI, Lucknow, India. Electronic address:

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http://dx.doi.org/10.1016/j.amjsurg.2019.03.003DOI Listing
March 2019
1 Read
2.291 Impact Factor

[Tetany as a form of presentation of adult celiac disease.]

Rev Fac Cien Med Univ Nac Cordoba 2019 02 27;76(1):56-58. Epub 2019 Feb 27.

Dpto. de Medicina Interna. Hospital Nacional. Itauguá, Paraguay.

Introduction: celiac disease is an autoimmune disease with symptoms involving multiple organs. The forms of presentation vary considerably, which makes it difficult to diagnose. The objective is to present an atypical case of celiac disease. Read More

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http://dx.doi.org/10.31053/1853.0605.v76.n1.20212DOI Listing
February 2019
4 Reads

Frequency of Hypocalcaemia following Total Thyroidectomy.

Pak J Med Sci 2019 Jan-Feb;35(1):262-265

Dr. Masooma Naseem, MBBS Student, Ziauddin University, Karachi, Pakistan.

Background & Objective: Patients who undergo Total thyroidectomy are at higher risk for postoperative hypocalcaemia, which can lead to significant short and long term morbidity. The aim of this study was to determine the frequency of postoperative hypocalcaemia undergoing Total thyroidectomy.

Methods: A total of 854 patients who underwent Total thyroidectomy and completion thyroidectomy between January 2003 to December 2016 at Endocrine Surgical unit, Jinnah Postgraduate Medical Centre, Karachi, were included in this retrospective study. Read More

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http://dx.doi.org/10.12669/pjms.35.1.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408675PMC
March 2019
1 Read

The clinical application of mental nerve dissection in transoral endoscopic thyroidectomy via an oral vestibular approach.

Surg Endosc 2019 Mar 14. Epub 2019 Mar 14.

The Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, China.

Background: Transoral endoscopic thyroidectomy vestibular approach is the natural orifice surgery to avoid surgical scars. However, mental nerve injury is a characteristic complication. Herein, we report the development of a novel method to dissect the mental nerve proactively during surgery to minimize the morbidity from mental nerve injury. Read More

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http://dx.doi.org/10.1007/s00464-019-06743-9DOI Listing
March 2019
3 Reads

An integrated analysis of safety and tolerability of etelcalcetide in patients receiving hemodialysis with secondary hyperparathyroidism.

PLoS One 2019 15;14(3):e0213774. Epub 2019 Mar 15.

Amgen Inc., Thousand Oaks, California, United States of America.

Background: Calcimimetics have been shown to be effective and safe therapies for the treatment of secondary hyperparathyroidism (sHPT), a serious complication of disordered mineral metabolism associated with dialysis-dependent chronic kidney disease. Etelcalcetide, a recently approved intravenous calcimimetic, reduces serum parathyroid hormone (PTH), calcium, phosphorus, and fibroblast growth factor-23 concentrations. Here we report the first integrated safety profile of etelcalcetide using pooled data from five pivotal clinical trials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213774PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420005PMC
March 2019
12 Reads
3.234 Impact Factor

Superior parathyroid blood supply safety in thyroid cancer surgery: A randomized controlled trial.

Int J Surg 2019 Apr 12;64:33-39. Epub 2019 Mar 12.

Department of ICU, Jining No. 1 People's Hospital, No. 6, Jiankang Road, Jiningy, 272011, Shandong, People's Republic of China. Electronic address:

Background: To evaluate the clinical value of a technique protecting blood supply to the superior parathyroid during surgery for thyroid cancer.

Materials And Methods: The observation group comprised 113 patients admitted to our hospital during the period from January 1, 2016 to December 31, 2016, who were diagnosed with thyroid cancer and treated by surgery using a technique protecting blood supply to the superior parathyroid. The control group comprised 113 patients diagnosed with thyroid cancer who were treated by surgery using the conventional technique. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.019DOI Listing

Short-term outcome associated with disease severity and electrolyte abnormalities among critically ill children with acute kidney injury.

BMC Nephrol 2019 Mar 12;20(1):89. Epub 2019 Mar 12.

Pediatric Nephrology Center of Excellence, Pediatric Department, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

Background: Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and morbidity.

Methods: Multicenter prospective cohort study was conducted over two years period. Read More

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http://dx.doi.org/10.1186/s12882-019-1278-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417256PMC
March 2019
1.520 Impact Factor

CRYOPRESERVATION OF PARATHYROID TISSUE: A WHITE PAPER ON ESTABLISHING A LOCAL SERVICE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

Andrology Laboratory and Sperm Bank, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland.

Objectives: Preservation of parathyroid function is one of the primary tenets of endocrine surgery. For patients with thyroid disease, an inadvertently compromised parathyroid gland is routinely auto transplanted into the neck at the time of surgery. By contrast for patients with parathyroid disease secondary to hyperplasia, the timing of auto transplantation needs to be further considered in order to balance the risks between persistent disease and permanent hypocalcaemia. Read More

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http://dx.doi.org/10.4158/EP-2018-0547DOI Listing
March 2019
7 Reads

Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review.

Case Rep Nephrol 2019 4;2019:4890287. Epub 2019 Feb 4.

Division of Pulmonary and Critical Care Medicine, Pikeville Medical Center, USA.

Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Read More

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http://dx.doi.org/10.1155/2019/4890287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378786PMC
February 2019
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Treatment-related adverse effects with TKIs in patients with advanced or radioiodine refractory differentiated thyroid carcinoma: a systematic review and meta-analysis.

Cancer Manag Res 2019 14;11:1525-1532. Epub 2019 Feb 14.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China,

Background: Tyrosine kinase inhibitors (TKIs) have been administered to advanced or radio-iodine refractory differentiated thyroid carcinoma (RR-DTC) patients for years. We performed a pooled analysis to explore the frequency of severe adverse effects in advanced or RR-DTC patients treated with sorafenib and lenvatinib.

Methods: We performed a comprehensive search of computerized databases, including PubMed, Web of Science, Ovid, EMASE, and the Cochrane Library, from the drugs' inception to July 2018 to identify clinical trials. Read More

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http://dx.doi.org/10.2147/CMAR.S191499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388981PMC
February 2019
1 Read

One-year safety and efficacy of intravenous etelcalcetide in patients on hemodialysis with secondary hyperparathyroidism.

Nephrol Dial Transplant 2019 Mar 11. Epub 2019 Mar 11.

Denver Nephrology, Denver, CO, USA.

Background: Secondary hyperparathyroidism (sHPT), a common complication of chronic kidney disease, is characterized by elevated serum parathyroid hormone (PTH). Etelcalcetide is an intravenous calcimimetic that increases sensitivity of the calcium-sensing receptor to calcium and decreases PTH secretion. This open-label extension (OLE) trial evaluated the long-term effects of etelcalcetide for sHPT treatment in patients receiving hemodialysis. Read More

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http://dx.doi.org/10.1093/ndt/gfz039DOI Listing

Hypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma.

Caspian J Intern Med 2019 ;10(1):111-117

Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain.

Background: Enteropathy-associated T-cell lymphoma (EATL) is a rare and aggressive type of extranodal T-cell lymphoma (TCL) arising in the gastrointestinal (GI) tract and represents 5-8% of all T-cell non-Hodgkin lymphomas (NHL) and 10-25% of primary intestinal lymphomas.

Case Presentation: We reported a 78-year-old woman presenting with severe hypocalcemia. Investigations confirmed vitamin D and iron deficiency as well as hypoalbuminemia. Read More

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http://dx.doi.org/10.22088/cjim.10.1.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386331PMC
January 2019
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Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period.

Endocr Metab Immune Disord Drug Targets 2019 Feb 15. Epub 2019 Feb 15.

The Departments of Pediatrics. Afiyet Hospital. Ümraniye, İstanbul. Turkey.

Objective: Maternal vitamin D deficiency is an important risk factor that causes infantile rickets in the neonatal and infantile period. The aim of this study was to review the prevalence, clinical characteristics and treatment of vitamin D deficiency andthe follow-upswith infants and their mothers by the neonatal intensive care unit of Afiyet Hospital in Turkey.

Materials And Methods: Calcium (Ca), phosphorus (P) and 25 (OH) vitamin D were studied and prospectively recorded in infants and their mothers detected to have hypocalcemia during routine biochemistry tests performed on the third postnatal day of the patients follow up and treated with different diagnoses. Read More

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http://www.eurekaselect.com/170044/article
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http://dx.doi.org/10.2174/1871530319666190215152045DOI Listing
February 2019
7 Reads

Efficacy and safety of denosumab compared to bisphosphonates in improving bone strength in postmenopausal osteoporosis: a systematic review.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

Introduction: Osteoporosis is the main cause of fractures among women after menopause. This study aimed to evaluate the efficacy and safety of denosumab compared to bisphosphonates in treating postmenopausal osteoporosis.

Methods: Databases including PubMed and the Cochrane Central Register of Controlled Trials were systematically searched for randomised controlled trials (RCTs) that directly compared denosumab and bisphosphonates. Read More

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http://dx.doi.org/10.11622/smedj.2019028DOI Listing
March 2019
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Management of Endocrine Emergencies in the ICU.

Authors:
Judith Jacobi

J Pharm Pract 2019 Mar 10:897190019834771. Epub 2019 Mar 10.

1 Pharmacy Department, Indiana University Health Methodist Hospital, Indianapolis, IN, USA.

Endocrine emergencies are frequent in critically ill patients and may be the cause of admission or can be secondary to other critical illness. The ability to anticipate endocrine abnormalities such as adrenal excess or , hypothyroidism, can mitigate their duration and severity. Hyperglycemic crisis may trigger hospital and intensive care unit (ICU) admission and may be life threatening. Read More

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http://dx.doi.org/10.1177/0897190019834771DOI Listing
March 2019
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