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    1 OF 291

    Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2.
    Br J Surg 2018 Apr 17. Epub 2018 Apr 17.
    Division of Endocrine Surgery, University College Hospital and Great Ormond Street Hospital, London, UK.
    Background: In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy of treatment, which depends on timely and safe surgery, is not well established.

    Methods: This was a retrospective review of diagnostic and clinicopathological outcomes of prophylactic thyroidectomy in children with MEN2 between 1995 and 2013 in the UK. Read More

    Quality of life in thyroid cancer-assessment of physician perceptions.
    J Surg Res 2018 Jun 15;226:94-99. Epub 2018 Feb 15.
    Department of Surgery, Endocrine Surgery Research Program, University of Chicago Pritzker School of Medicine, Chicago, Illinois.
    Background: Thyroid cancer is the fastest growing malignancy in the United States. Previous studies have shown a decrease in quality of life (QoL) after the treatment of thyroid cancer. To date, there have been no studies assessing physician perceptions regarding how a diagnosis of thyroid cancer affects QoL. Read More

    The FGF-23/Klotho axis and its relationship with phosphorus, calcium, vitamin D, PTH, aldosterone, severity of disease, and outcome in hospitalised foals.
    Equine Vet J 2018 Apr 16. Epub 2018 Apr 16.
    Faculty of Veterinary Medicine, University of Sadat City, Egypt.
    Background: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking.

    Objectives: The aims of this study were to measure serum FGF-23 and klotho concentrations and determine their association with serum phosphorus, total calcium (TCa), vitamin D metabolite [25(OH)D, 1,25(OH) D], PTH, and aldosterone concentrations, disease severity, and mortality in hospitalised foals.

    Study Design: Prospective, multicentre, cross-sectional study. Read More

    Hypocalcemia Presenting as Life Threatening Torsades de Pointes with Prolongation of QTc Interval.
    Indian J Clin Biochem 2018 Apr 1;33(2):235-238. Epub 2017 Aug 1.
    1Present Address: Department of Cardiology, Dayanand Medical College and Hospital, Civil Lines, Tagore Nagar, Ludhiana, 141001 India.
    Torsades de pointes with prolonged QTc interval is a form of ventricular tachycardia. Many predisposing factors have been identified and hypocalcemia is among the rare ones. Our case illustrates that though rare, hypocalcemia might manifest as torsades de pointes with prolongation of QTc interval. Read More

    Pretreatment of enteral nutrition with sodium polystyrene sulfonate: effective, but beware the high prevalence of electrolyte derangements in clinical practice.
    Clin Kidney J 2018 Apr 21;11(2):166-171. Epub 2017 Dec 21.
    Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Background: Current treatment options for chronic hyperkalemia in children with chronic kidney disease include dietary restrictions or enteral sodium polystyrene sulfonate (SPS); however, dietary restrictions may compromise adequate nutrition and enteral SPS may be limited by palatability, adverse effects and feeding tube obstruction. A potentially safer alternative is to pretreat enteral nutrition (EN) with SPS prior to consumption. The purpose of this study was to evaluate the efficacy and safety of pretreating EN with SPS in pediatric patients with hyperkalemia. Read More

    [Symptomatic hypocalcemia after thyroidectomy : Prevention by a combination of prophylaxis and risk-adapted substitution].
    Chirurg 2018 Apr 10. Epub 2018 Apr 10.
    Klinik für Allgemein- und Visceralchirurgie, Referenzzentrum für Schilddrüsen- und Nebenschilddrüsenchirurgie, Krankenhaus Martha-Maria, Stadenstraße 58, 90491, Nürnberg, Deutschland.
    Background: Treatment of hypocalcemia after thyroidectomy consists of an individual substitution, prophylaxis or a daily administration of calcium/vitamin D3.

    Objective: Does prophylactic therapy combined with a risk-adapted substitution of calcium and vitamin D3 reduce symptomatic hypocalcemia compared to individual substitution?

    Material And Methods: After implementation of a new algorithm, patient data were prospectively documented and analyzed compared to a historical patient population. The algorithm consisted of a single prophylactic i. Read More

    [Preventive management of bone disease in advanced prostate cancer.]
    Arch Esp Urol 2018 03;71(3):258-266
    Director Unidad Cáncer de Próstata. Servicio de Urología. Hospital General Universitario Morales Meseguer. Murcia. España.
    Objectives: Prostate cancer is linked to bone disease by two different entities. On one hand, androgen deprivation therapy (ADT) usually causes osteoporosis, on the other a great number of patients with advanced prostate cancer will present bone that condition not only their vital prognosis but also an important quality of life deterioration.

    Methods: We performed a bibliographic review on both the physiology and therapy of osteoporosis secondary to ADT and bone metastasis in prostatic neoplasias. Read More

    Current treatment of hypoparathyroidism: Theory versus reality waiting guidelines for children and adolescents.
    Acta Biomed 2018 Mar 27;89(1):122-131. Epub 2018 Mar 27.
    .
    The diagnosis of hypoparathyroidism(HPT)is readily made in the presence of hypocalcemia with markedly reduced or absent parathormone (PTH) levels. Currently available treatments for HPT include high dose vitamin D (ergocalciferol, D2 and cholecalciferol, D3) or, the active metabolite dihydroxy vitamin D (calcitriol), in addition to calcium supplements.This regimen, if not well monitored, can lead to hypercalciuria, as PTH deficiency impairs renal calcium reabsorption. Read More

    Predictive values of diagnostic codes for identifying serious hypocalcemia and dermatologic adverse events among women with postmenopausal osteoporosis in a commercial health plan database.
    BMC Health Serv Res 2018 Apr 10;18(1):263. Epub 2018 Apr 10.
    Optum Epidemiology, 1325 Boylston Street, Suite 1000, Boston, MA, 02215, USA.
    Background: Post-marketing safety studies of medicines often rely on administrative claims databases to identify adverse outcomes following drug exposure. Valid ascertainment of outcomes is essential for accurate results. We aim to quantify the validity of diagnostic codes for serious hypocalcemia and dermatologic adverse events from insurance claims data among women with postmenopausal osteoporosis (PMO). Read More

    Should total calcium be adjusted for albumin? A retrospective observational study of laboratory data from central Norway.
    BMJ Open 2018 Apr 7;8(4):e017703. Epub 2018 Apr 7.
    Department of Clinical Chemistry, St.Olavs hospital, Trondheim, Norway.
    Objectives: Albumin-adjusted total calcium is often used as a surrogate marker for free calcium to evaluate hypocalcaemia or hypercalcaemia. Many adjustment formulas based on simple linear regression models have been published, and continue to be used in spite of questionable diagnostic accuracy. In the hope of finding a more pure albumin effect on total calcium, we used multiple linear regression models to adjust for other relevant variables. Read More

    Clinical and laboratory features of patients with osteomalacia initially presenting with neurological manifestations.
    Osteoporos Int 2018 Apr 5. Epub 2018 Apr 5.
    Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
    Patients with osteomalacia often visit the neurology department with conditions mimicking other myopathies. We analyzed clinical features of osteomalacia patients who visited the neurology department. These patients frequently presented with hypocalcemia, hypovitaminosis D, and pain with less severe weakness. Read More

    Hypocalcaemia in an adult: the importance of not overlooking the cause.
    BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.
    Department of Internal Medicine, Setúbal Hospital Center, Setúbal, Portugal.
    A 58-year-old male patient was admitted at the São Bernardos's Hospital (Setúbal, Portugal) with generalised muscle spasms, dyspnoea, laryngospasm and bronchospasm in the context of severe hypocalcaemia. Despite efforts to correct serum calcium, it remained below average, leading to question the true cause of hypocalcaemia. Low parathyroid hormone and 25-hydroxyvitamin D, along with facial anomalies, palate defect and cognitive impairment with concomitant psychiatric disorder led to a suspicion of a DiGeorge/velocardiofacial/22q11. Read More

    Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.
    Proc Natl Acad Sci U S A 2018 Apr 4;115(16):E3749-E3758. Epub 2018 Apr 4.
    Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115;
    The pathogenesis of parathyroid gland hyperplasia is poorly understood, and a better understanding is essential if there is to be improvement over the current strategies for prevention and treatment of secondary hyperparathyroidism. Here we investigate the specific role of Klotho expressed in the parathyroid glands (PTGs) in mediating parathyroid hormone (PTH) and serum calcium homeostasis, as well as the potential interaction between calcium-sensing receptor (CaSR) and Klotho. We generated mouse strains with PTG-specific deletion of Klotho and CaSR and dual deletion of both genes. Read More

    Serotonin induces parathyroid hormone-related protein in goat mammary gland.
    J Anim Sci 2018 Apr;96(3):1010-1016
    College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
    During lactation, large amounts of calcium are exported from the mammary gland into milk to ensure skeletal growth of the offspring. Recent studies revealed that serotonin (5-HT) is essential to stimulate skeletal calcium resorption for milk synthesis. Our objective was to explore the correlation between circulating 5-HT and serum calcium and parathyroid hormone-related protein (PTHrP) concentrations around parturition in dairy goats. Read More

    Hypomagnesemia in critically ill patients.
    J Intensive Care 2018 27;6:21. Epub 2018 Mar 27.
    2Section for Endocrinology, Department of Clinical Science, University of Bergen, Bergen, Norway.
    Background: Magnesium (Mg) is essential for life and plays a crucial role in several biochemical and physiological processes in the human body. Hypomagnesemia is common in all hospitalized patients, especially in critically ill patients with coexisting electrolyte abnormalities. Hypomagnesemia may cause severe and potential fatal complications if not timely diagnosed and properly treated, and associate with increased mortality. Read More

    Pseudogout - a rare manifestation of hungry bone syndrome after focused parathyroidectomy.
    Ann R Coll Surg Engl 2018 Apr 1:e1-e3. Epub 2018 Apr 1.
    Division of General Surgery (Thyroid and Endocrine Surgery), University Surgical Cluster, Department of Surgery, National University Health System , Singapore.
    Pseudogout, also known as calcium pyrophosphate deposition disease, is a rheumatological condition arising from accumulation of calcium pyrophosphate dihydrate crystals in connective tissues. We present a case of a 56-year-old Bangladeshi woman who underwent focused right inferior parathyroidectomy for primary hyperparathyroidism from a right inferior parathyroid adenoma. On the first post-operative day, she complained of left elbow painful swelling with redness and warmth. Read More

    Effect of nerve monitoring on complications of thyroid surgery.
    North Clin Istanb 2018 19;5(1):14-19. Epub 2018 Jan 19.
    Department of Otolaryngology Surgery, Lutfiye Nuri Burat State Hospital, Istanbul, Turkey.
    Objective: The most frequent and critical complications of thyroid surgery are recurrent laryngeal nerve palsy and hypocalcemia. In first years of the 21st century, intraoperative neuromonitoring (IONM) was introduced as a new technique to avoid the recurrent laryngeal nerve (RLN) injury. However, the role and the benefits of IONM are still controversial. Read More

    Interaction of 5-hydroxy-l-tryptophan and negative dietary cation-anion difference on calcium homeostasis in multiparous peripartum dairy cows.
    J Dairy Sci 2018 Mar 28. Epub 2018 Mar 28.
    Department of Dairy Science, University of Wisconsin, Madison 53706. Electronic address:
    Hypocalcemia affects almost 50% of all dairy cows. Our laboratory has previously demonstrated that infusions of the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP) increase circulating calcium concentrations in the Holstein transition cow. It is unknown whether feeding a negative DCAD diet alters the relationship between 5-HTP and hypocalcemia. Read More

    Insights into calcium-sensing receptor trafficking and biased signalling by studies of calcium homeostasis.
    J Mol Endocrinol 2018 Mar 29. Epub 2018 Mar 29.
    C Gorvin, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland
    The calcium-sensing receptor (CaSR) is a class C G-protein coupled receptor (GPCR) that detects extracellular calcium concentrations, and modulates parathyroid hormone secretion and urinary calcium excretion to maintain calcium homeostasis. The CaSR utilises multiple heterotrimeric G-proteins to mediate signalling effects including: activation of intracellular calcium release; mitogen-activated protein kinase (MAPK) pathways; membrane ruffling; and inhibition of cAMP production. By studying germline mutations in the CaSR and proteins within its signalling pathway that cause hyper- and hypocalcaemic disorders, novel mechanisms governing GPCR signalling and trafficking have been elucidated. Read More

    Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.
    Front Horm Res 2018 29;50:1-13. Epub 2018 Mar 29.
    Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing receptor (CaSR) on the parathyroid cells, leading to an increase in intracellular calcium. This in turn leads to a reduced parathyroid hormone (PTH) release. Read More

    Clinical Complications of Continuous Renal Replacement Therapy.
    Contrib Nephrol 2018 29;194:109-117. Epub 2018 Mar 29.
    The various complications of continuous renal replacement therapy (CRRT) are mostly preventable. Hemodynamic disturbances are dominated by hypotension due to the modification of volume status, myocardial dysfunction, cardiac arrhythmia, or modification of systemic vascular resistances, which are correlated with body temperature changes. Metabolic complications remain at the forefront and have profoundly changed with the use of regional citrate anticoagulation (RCA). Read More

    Iatrogenic hypoparathyroidism after surgery for retrosternal goitre. A single centre retrospective analysis.
    Clin Ter 2018 Mar-Apr;169(2):e67-e70
    Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Italy.
    Aim: The aim of this study is to assess, retrospectively, the incidence of secondary hypoparathyroidism after total thyroidectomy in patients with retrosternal goitre.

    Material And Methods: From January 2009 to September 2015, 622 patients who undergone total thyroidectomy for goitre, were retrospectively observed. The patients were divided into two group: Group A, including 58 patients with retrosternal goitre and Group B, including 562 patients with in situ goitre. Read More

    Parathyroid Hormone Assays following Total Thyroidectomy: Is There a Predictive Value?
    Eur Thyroid J 2018 Jan 7;7(1):34-38. Epub 2017 Dec 7.
    Department of Biochemistry and Molecular Biology, University Hospital of Nîmes, Nîmes, France.
    Objectives: Parathyroid hormone (PTH) is a risk marker for hypoparathyroidism (hypoPTH). This study aimed to determine the predictive values of early PTH assays carried out at the moment of skin closure (PTH SC), to establish a treatment algorithm, identifying two threshold values. We assessed the reproducibility of this approach with two different immunoassay kits (hypoPTH) after total thyroidectomy, but its practical application is not consensual. Read More

    Systematic Review and Meta-analysis of Unplanned Reoperations, Emergency Department Visits, and Hospital Readmission After Thyroidectomy.
    Thyroid 2018 Mar 27. Epub 2018 Mar 27.
    University of British Columbia, 8166, Surgery, Vancouver, British Columbia, Canada.
    Background: Unplanned reoperation, Emergency Department (ED) visits, and hospital readmission following thyroid operations usually arise due to complications, and are a source of frustration for both surgeons and patients. With an aim to provide insight important for the development of patient quality care improvement initiatives, the primary objective of this review was to systematically evaluate the available literature in order to determine the contemporary rates of reoperation, readmission and ED visits following thyroid operations. A secondary study objective was to determine if there were any practices that showed promise in reducing the occurrence of these undesirable post-operative events. Read More

    Parkinson's disease with hypocalcaemia: adult presentation of 22q11.2 deletion syndrome.
    BMJ Case Rep 2018 Mar 22;2018. Epub 2018 Mar 22.
    Division of Movement Disorders, Department of Neurology, Coimbra Hospital and University Centre, Coimbra, Portugal.
    A growing amount of evidence indicates that 22q11.2 deletion syndrome (22q11.2DS) increases the risk of early-onset Parkinson's disease (EOPD). Read More

    Efficacy of Denosumab for Osteoporosis in Two Patients with Adult-Onset Still's Disease-Denosumab Efficacy in Osteoporotic Still's Disease Patients.
    J Clin Med 2018 Mar 22;7(4). Epub 2018 Mar 22.
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan.
    Adult-onset Still's disease (AOSD) is an autoimmune inflammatory disorder. Glucocorticoids are often used for AOSD, which may induce complicating glucocorticoid-induced osteoporosis (GIO). An anti-resorption drug, denosumab, has recently been approved for osteoporosis treatment in Japan. Read More

    Menstrual disorders and premenstrual symptoms in adolescents: prevalence and relationship to serum calcium and vitamin D concentrations.
    J Obstet Gynaecol 2018 Mar 21:1-7. Epub 2018 Mar 21.
    e Metabolic Syndrome Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
    There have been several studies evaluating the association between vitamin and mineral status and menstrual disturbance. In the present study, we aimed to assess the relationship between the menstrual bleeding pattern and premenstrual syndrome (PMS) symptoms with serum 25-hydroxyvitamin D, and calcium levels in adolescent girls. A cross-sectional study was carried out in 897 high school girls from northeastern Iran. Read More

    Comparison of umbilical artery Doppler and non-stress test in assessment of fetal well-being in gestational diabetes mellitus: A prospective cohort study.
    Electron Physician 2017 Dec 25;9(12):6087-6093. Epub 2017 Dec 25.
    Ph.D. of Reproductive Health, Assistant professor, Department of Midwifery, School of Nursing & Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran.
    Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy and is related to poor perinatal outcomes. Reduction of neonatal complications of GDM is feasible by assessment of fetal well-being. Both fetal Doppler and NST are used for the screening of high-risk pregnancies. Read More

    Moderate glucose supply reduces hemolysis during systemic inflammation.
    J Inflamm Res 2018 12;11:87-94. Epub 2018 Mar 12.
    Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany.
    Background: Systemic inflammation alters energy metabolism. A sufficient glucose level, however, is most important for erythrocytes, since erythrocytes rely on glucose as sole source of energy. Damage to erythrocytes leads to hemolysis. Read More

    Significant improvement of bone mineral density by denosumab treatment in Japanese osteoporotic patients following breast cancer treatment.
    Ther Clin Risk Manag 2018 14;14:543-549. Epub 2018 Mar 14.
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto.
    Background: The aim of this study was to evaluate the effects of denosumab in patients with osteoporosis (OP) and non-metastatic breast cancer following treatment of 1) surgery, 2) surgery and aromatase inhibitors, and 3) surgery, aromatase inhibitors, and anti-cancer agents, compared with those in primary OP patients.

    Patients And Methods: In this retrospective 24-month study, patients were divided into the primary OP group (34 cases) or OP receiving breast cancer treatment group (breast cancer group; 17 cases). We measured serum calcium, whole parathyroid hormone (PTH), 1,25OHD, bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase-5b (TRACP-5b), and bone mineral density (BMD) of the lumbar 1-4 vertebrae (L-BMD) and bilateral total hips (H-BMD) for 24 months. Read More

    Comparison of 0.46% calcium diets with and without added anions with a 0.7% calcium anionic diet as a means to reduce periparturient hypocalcemia.
    J Dairy Sci 2018 Mar 14. Epub 2018 Mar 14.
    College of Veterinary Medicine, Iowa State University, Ames 50011.
    Most studies demonstrating that diets with low dietary cation-anion difference (DCAD) reduce hypocalcemia in cows add enough anions to the diet to reduce urine pH below 7.0. One objective of these experiments was to determine whether there is any benefit to periparturient plasma Ca concentration if diet anion addition results in a lesser degree of acidification of the cow and urine pH does not go below 7. Read More

    Update on sutureless thyroidectomy.
    G Chir 2018 Jan-Feb;39(1):45-50
    Introduction: The Harmonic scalpel ("Focus" and the new version "Focus+") is one of the first devices for surgical simultaneous cutting and tissue coagulation which allows to obtain dissection and hemostasis by direct application of ultrasound and allows minimally invasive surgical procedures with minimal lateral thermal spread and, thus, minimal adjacent tissue destruction. The aim of the study is to complete the previous study that we made in 2014, based on the TT performed between January 2008 and December 2013, with new data about TT performed in our Surgical Division between January 2014 and December 2016 and compare the outcome using the Ultrasonic scalpel versus the device Ligasure in term of safety, operative time, overall drainage volume, complications, hospital stay.

    Patients And Methods: 250 patients were randomized into two groups: Group A where Ultracision were used and Group B where the Ligasure device was used. Read More

    Electrolyte Abnormalities in Neonates with Probable and Culture-Proven Sepsis and its Association with Neonatal Mortality.
    J Coll Physicians Surg Pak 2018 03;28(3):206-209
    Department of Pediatrics, Fazle Omar Hospital, Chenab Nagar, Rabwah, Pakistan.
    Objective: To ascertain the frequency of electrolyte abnormalities in patients of probable and culture-proven sepsis on admission and assess any association of electrolyte disorders with mortality.

    Study Design: Descriptive study.

    Place And Duration Of Study: NICU, Fazle-Omar Hospital, Rabwah, from October 2015 to September 2016. Read More

    Neonatal hypocalcemia and its relation to vitamin D and calcium supplementation.
    Saudi Med J 2018 Mar;39(3):247-253
    Department of Public Health, Faculty of Medicine, Fayoum University, Fayoum, Egypt. E-mail.
    Objectives: To assess the prevalence of hypocalcemia in outpatient clinic neonates and its relation to vitamin D and calcium supplementation.  Methods: This cross-sectional analytical study was conducted at the University Teaching Hospital from May to October 2016. Data were collected from 100 neonates by interviewing mothers using a structured questionnaire; which included socio-demographic information, maternal and neonatal history; in addition to investigations of serum calcium total and ionized and serum vitamin D level. Read More

    Blood calcium, glucose and haematology profiles of parturient bitches diagnosed with uterine inertia or obstructive dystocia.
    Reprod Domest Anim 2018 Mar 14. Epub 2018 Mar 14.
    Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
    Bitches with dystocia most often present with clinical signs of uterine inertia (UI). The aetiology of myometrial dysfunction in most of these cases is still not elucidated. We compared blood ionized calcium (iCa) and glucose concentrations in bitches diagnosed with primary UI (PUI, n = 14), secondary UI (SUI, n = 6) or obstructive dystocia (OD, n = 6), and we described their haematology profiles. Read More

    [Management of the dry and transition periods of dairy cattle in free stall housing systems in Lower Saxony. - Part 2: Risk factores for subclinical ketosis, hypocalcaemia and increased lipomobilisation].
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2018 Feb 21;46(1):13-21. Epub 2018 Feb 21.
    Objective: Determination of the frequency of subclinical hypocalcaemia, increased lipomobilisation and subclinical ketosis as problems in dairy herds and identification of possible risk factors.

    Material And Methods: Information was obtained from 51 dairy farms on husbandry, feeding, management of the cows and heifers, animal health and prophylactic treatments using a questionnaire. Blood samples from 20% of the cows and 30% of the heifers of each farm (= herd sample) were collected in the week ante partum (a. Read More

    Clinical Predictors and Outcomes of Patients with Pericardial Effusion in Chronic Kidney Disease.
    Clin Cardiol 2018 Mar 13. Epub 2018 Mar 13.
    Division of Cardiology, Cook County Health and Hospitals System, Chicago, IL.
    Background: Pericardial effusion is common in hospitalized patients with chronic kidney disease (CKD). We sought to identify predictors of pericardial effusion in CKD patients and to evaluate the impact of pericardial effusion on their mortality and morbidity.

    Methods: In a retrospective nested case control study design, we analyzed hospitalized adult patients with CKD stage 4, 5, and end-stage renal disease (ESRD) diagnosed with pericardial effusion. Read More

    Calcimimetics versus parathyroidectomy: What is preferable?
    Int Urol Nephrol 2018 Mar 12. Epub 2018 Mar 12.
    University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia.
    Secondary hyperparathyroidism (SHPT) is common among patients with end-stage renal disease (ESRD). SHPT is associated with high-turnover bone disease, interstitial and vascular calcifications, cardiovascular morbidity and mortality. The pharmacological management of SHPT has progressed in recent years. Read More

    Medial Approach for the Resection of Goiters with Suprahyoid, Retropharyngeal, or Substernal Extension.
    World J Surg 2018 05;42(5):1415-1423
    Department of Otolaryngology - Head and Neck Surgery, University of Nevada Las Vegas School of Medicine, 1701 W Charleston Blvd, Suite 490, Las Vegas, NV, 89102, USA.
    Background: Resection of massive goiters with suprahyoid, retropharyngeal, and substernal extension may not be amenable to standard approaches. This study evaluates a surgical approach allowing resection of massive goiters with minimal substernal and deep neck dissection.

    Methods: Cases of thyroidectomy for goiters with substernal, retropharyngeal, or suprahyoid extension at a single institution from 2006 to 2017 were reviewed. Read More

    Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan.
    Endocr J 2018 Mar 10. Epub 2018 Mar 10.
    Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
    There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. Read More

    Incidence, predictors and therapeutic consequences of hypocalcemia in patients treated with cinacalcet in the EVOLVE trial.
    Kidney Int 2018 Mar 7. Epub 2018 Mar 7.
    Memorial University, St. John's, Canada.
    The calcimimetic cinacalcet is used to treat secondary hyperparathyroidism in patients receiving dialysis, and asymptomatic hypocalcemia is often observed following its initiation. Here we investigated the incidence, predictors and therapeutic consequences of hypocalcemia by a post hoc analysis of the randomized, double-blind, placebo-controlled EValuation Of Cinacalcet Hydrochloride Therapy to Lower CardioVascular Events (EVOLVE) trial. Hypocalcemia was classified as mild (total serum calcium 8. Read More

    Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
    Clin J Am Soc Nephrol 2018 Mar 9. Epub 2018 Mar 9.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California, Irvine, California
    Secondary hyperparathyroidism develops in CKD due to a combination of vitamin D deficiency, hypocalcemia, and hyperphosphatemia, and it exists in nearly all patients at the time of dialysis initiation. There is insufficient data on whether to prefer vitamin D analogs compared with calcimimetics, but the available evidence suggests advantages with combination therapy. Calcium derangements, patient adherence, side effects, and cost limit the use of these agents. Read More

    Effects of denosumab on bone mineral density in Japanese women with osteoporosis treated with aromatase inhibitors for breast cancer.
    J Bone Miner Metab 2018 Mar 8. Epub 2018 Mar 8.
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
    Adjuvant aromatase inhibitor (AI) therapy, for hormone receptor-positive breast cancer, in postmenopausal women is associated with bone loss, leading to an increased risk of fractures. Denosumab, an antibody raised against the receptor activator of nuclear factor-κB ligand, has been proven to protect against AI-induced bone loss. Hence, we aimed to determine whether denosumab is effective in postmenopausal Japanese women with osteoporosis, treated with AI. Read More

    Etidronate for Prevention of Ectopic Mineralization in Patients With Pseudoxanthoma Elasticum.
    J Am Coll Cardiol 2018 Mar;71(10):1117-1126
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:
    Background: In pseudoxanthoma elasticum (PXE), low pyrophosphate levels may cause ectopic mineralization, leading to skin changes, visual impairment, and peripheral arterial disease.

    Objectives: The authors hypothesized that etidronate, a pyrophosphate analog, might reduce ectopic mineralization in PXE.

    Methods: In the Treatment of Ectopic Mineralization in Pseudoxanthoma Elasticum trial, adults with PXE and leg arterial calcifications (n = 74) were randomly assigned to etidronate or placebo (cyclical 20 mg/kg for 2 weeks every 12 weeks). Read More

    Metabolic predictors of peri-partum diseases and their association with parity in dairy cows.
    Res Vet Sci 2018 Feb 19;118:191-198. Epub 2018 Feb 19.
    Veterinary Faculty, Federal University of Pampa, Uruguaiana, Brazil.
    The predictive values of plasma non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), cholesterol, albumin and calcium to predict risk of peripartum diseases in primiparous (PP) and multiparous (MP) Holstein cows was investigated. Besides it was assessed if the health status interacted with parity on body condition score and metabolic profiles during the transition period. Dairy cows (126 PP and 182 MP) from a commercial dairy free stall herd (loose-housing system) were weekly body condition scored and tail bled for metabolites determination from -3 to +4 weeks relative to calving. Read More

    Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials.
    Nephron 2018 Mar 7. Epub 2018 Mar 7.
    Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
    Background: Cinacalcet could decrease serum calcium, phosphate, and parathyroid hormone (PTH) in previous meta-analyses. However, the effect of cinacalcet on the new biomarkers such as fibroblast growth factor-23 (FGF-23), bone markers, and vascular calcification are still unestablished. We conducted a meta-analysis to examine the effects of cinacalcet on all laboratory and clinical spectrums of chronic kidney disease-mineral bone disorders (CKD-MBD). Read More

    Case report of primary intestinal lymphangiectasia diagnosed in an octogenarian by ileal intubation and by push enteroscopy after missed diagnosis by standard colonoscopy and EGD.
    Medicine (Baltimore) 2018 Jan;97(3):e9649
    Department of Pathology, William Beaumont Hospital.
    Rationale: Primary intestinal lymphangiectasia (PIL) is a rare, presumably congenital lesion that is usually diagnosed in patients < 3 years old, is rarely first diagnosed in adulthood, and when first diagnosed in adulthood typically presents with symptoms for many years. Although PIL is often identified by endoscopic abnormalities, it must be emphasized that the jejunoileum/distal duodenum must be intubated for diagnosis because the lesions are present in these regions. This work demonstrates that 1)-PIL can occur in an octogenarian; 2)-shows that the characteristic endoscopic findings are not found at colonoscopy without terminal ileal intubation; and 3)-may be missed at standard EGD without distal duodenal intubation. Read More

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