15,649 results match your criteria Hypocalcemia


Continuous rhPTH (1-34) treatment in chronic hypoparathyroidism.

Endocrinol Diabetes Metab Case Rep 2020 May 29;2020. Epub 2020 May 29.

Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.

Summary: Standard treatment of hypoparathyroidism consists of supplementation of calcium and vitamin D analogues, which does not fully restore calcium homeostasis. In some patients, hypoparathyroidism is refractory to standard treatment with persistent low serum calcium levels and associated clinical complications. Here, we report on three patients (58-year-old male, 52-year-old female, and 48-year-old female) suffering from severe treatment-refractory postsurgical hypoparathyroidism. Read More

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http://dx.doi.org/10.1530/EDM-20-0009DOI Listing

Immune Modulation Properties of Zoledronic Acid on TcRγδ T-Lymphocytes After TcRαβ/CD19-Depleted Haploidentical Stem Cell Transplantation: An analysis on 46 Pediatric Patients Affected by Acute Leukemia.

Front Immunol 2020 12;11:699. Epub 2020 May 12.

Department of Pediatric Hematology and Oncology and of Cell and Gene Therapy, Scientific Institute for Research and Healthcare (IRCCS), Bambino Gesù Childrens' Hospital, Rome, Italy.

TcRαβ/CD19-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents a promising new platform for children affected by acute leukemia in need of an allograft and lacking a matched donor, disease recurrence being the main cause of treatment failure. The use of zoledronic acid to enhance TcRγδ+ lymphocyte function after TcRαβ/CD19-cell depleted haplo-HSCT was tested in an open-label, feasibility, proof-of-principle study. Forty-six children affected by high-risk acute leukemia underwent haplo-HSCT after removal of TcRαβ+ and CD19+ B lymphocytes. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235359PMC

Comparative Effectiveness of Calcimimetic Agents for Secondary Hyperparathyroidism in Adults: A Systematic Review and Network Meta-analysis.

Am J Kidney Dis 2020 May 28. Epub 2020 May 28.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; Sydney School of Public Health, The University of Sydney, NSW, Australia. Electronic address:

Rationale & Objective: Comparative benefits and harms of calcimimetic agents used for the treatment of secondary hyperparathyroidism have not been well characterized. We sought to compare the effectiveness of 3 calcimimetic agents using published data.

Study Design: Systematic review of randomized controlled trials and network meta-analysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.439DOI Listing

The Use of Vitamin D in Preventing Post-thyroidectomy Hypocalcemia: An Endocrinologist Survey Study.

Clin Endocrinol (Oxf) 2020 May 29. Epub 2020 May 29.

Department of Otolaryngology-Head & Neck Surgery, Boston Medical Center, Boston, MA, USA.

Objective: To evaluate the use of preoperative vitamin D levels and postoperative vitamin D supplementation among endocrinologists for the prevention of post-thyroidectomy hypocalcemia.

Methods: Endocrinologist members of the American Thyroid Association (ATA) were contacted via email to complete a 21-question survey, which included both questions about demographic information, and preventing and managing postoperative hypocalcemia after thyroidectomy. Univariate and multivariate analysis was performed to determine the respondents' use of preoperative vitamin D levels, dose and duration of preoperative vitamin D repletion, decision to delay surgery for low vitamin D levels in the case of a benign or malignant disease, and routine prescription of postoperative calcium or vitamin D supplementation. Read More

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http://dx.doi.org/10.1111/cen.14259DOI Listing

Falciparum Malaria Presenting With Tetany: Endocrinopathies Associated With Falciparum Malaria.

J Ayub Med Coll Abbottabad 2020 Jan- Mar;32(1):136-138

Internal Medicine Department, Dubai Hospital, Dubai Health Authority, United Arab Emirates.

Malaria is a common public health problem which may have high morbidity and mortality. Physicians should be aware of the unusual presentations of this disease so that it can be timely diagnosed and treated. Herein we are presenting a case of falciparum malaria who presented to the hospital with carpopedal spasm and tetany. Read More

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Outcomes after completion thyroidectomy versus total thyroidectomy for differentiated thyroid cancer: A single-center experience.

J Surg Oncol 2020 May 28. Epub 2020 May 28.

Division of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.

Background: Thyroid cancer diagnoses are often discovered after diagnostic thyroid lobectomy. Completion thyroidectomy (CT) may be indicated for intermediate or high-risk tumors to facilitate surveillance and/or adjuvant treatment. The completeness of thyroid resection and the safety of CT compared to total thyroidectomy (TT) is unclear. Read More

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http://dx.doi.org/10.1002/jso.26044DOI Listing

Unusual clinical features associated with congenital generalized lipodystrophy type 4 in a patient with a novel E211X gene variant.

Clin Diabetes Endocrinol 2020 14;6. Epub 2020 May 14.

Endocrinology Research Centre, 11, ulitsa Dmitriya Ulianova, Moscow, Russian Federation 117036 Russia.

Background: Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by the lack of adipose tissue and metabolic complications with predominantly autosomal recessive inheritance. There are 6 different genes known to cause CGL with 4 main types recognized to date, which differ by the degree of fat loss, association with mental retardation and metabolic disorders, with CGL type 1 and 2 being the most common. Twenty seven cases of СGL type 4 from Japan, Oman, UK, Turkey, Mexico, Saudi Arabia, USA were reported previously. Read More

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http://dx.doi.org/10.1186/s40842-020-00095-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227336PMC

Are Routine Postoperative Laboratory Tests Necessary After Primary Total Hip Arthroplasty?

J Arthroplasty 2020 May 7. Epub 2020 May 7.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Recently, the practice of ordering routine postoperative laboratory tests in primary total hip arthroplasty (THA) has been challenged. This study aimed to evaluate the utility of routine postoperative laboratory tests after primary elective THA in an Asian population and identify the risk factors associated with abnormal postoperative laboratory test-related intervention.

Methods: We retrospectively reviewed 395 consecutive patients who underwent primary elective THA at a single tertiary academic center. Read More

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http://dx.doi.org/10.1016/j.arth.2020.04.097DOI Listing

Preoperative Vitamin D Supplementation in Patients With Vitamin D Deficiency Undergoing Total Thyroidectomy.

Am J Med Sci 2020 May 6. Epub 2020 May 6.

Department of Cardiothoracic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Transient hypocalcemia due to parathyroid gland or vessel manipulation is a common complication following thyroidectomy. Considering the role of 25-hydroxyvitamin D (25(OH)D) in calcium hemostasis, this study aimed to evaluate the effect of preoperative vitamin D supplementation on hypocalcemia incidence in thyroidectomy patients.

Methods: In this randomized clinical trial, 100 patients scheduled for total thyroidectomy and suffering from preoperative moderate or severe vitamin D deficiency were enrolled. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.04.036DOI Listing

Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S145. Epub 2020 Mar 30.

Surgery, The University of Maryland, Baltimore, MD.

Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically engineered organ xenografts, including knock-out (KO) of alpha 1-3 galactosyltransferase (GTKO) along with insertion of a human complement regulator genes (hCD46, hDAF) and other cell surface carbohydrate KOs, has been helpful in circumventing acute and subacute rejection. However, thrombotic complications still remain. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1069DOI Listing

Mini-invasive thyroidectomy and Intraoperative Neuromonitoring (IONM): a single high-volume center experience in 215 consecutive cases.

Minerva Chir 2020 May 26. Epub 2020 May 26.

General Surgery Unit, Department of Medicine and Surgery, Parma University Hospital, Parma, Italy.

Background: Endocrine surgery recent evolution has been characterized by introduction of mini-invasive video-assisted technique. When a new technique is introduced in surgical use the rate of adverse events must be the same of previous standardized technique. In MIVAT procedure complication rate and in particular nerve injury risk is associated surgeon's experience. Read More

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http://dx.doi.org/10.23736/S0026-4733.20.08339-XDOI Listing

Combined ionized calcium and PTH evaluation in the management of post-thyroidectomy hypocalcaemia.

Minerva Chir 2020 May 26. Epub 2020 May 26.

S.C. Chirurgia Generale Ospedale Maria Vittoria, Dipartimento Area Chirurgica, ASL Città di Torino, Turin, Italy.

Background: Aim of our study was to investigate the postoperative course of calcium and parathyroid hormone (PTH) levels after total thyroidectomy to define a proper and low cost protocol.

Methods: We studied 144 patients who underwent total thyroidectomy between 2007 and 2010. Ionized calcium was determined preoperatively and on day 1 (POD1), day 2 (POD2) and day 7 (POD7) postoperatively; PTH preoperatively and on POD7. Read More

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http://dx.doi.org/10.23736/S0026-4733.20.08257-7DOI Listing

Lessons learnt from delayed diagnosis of FGF-23-producing tumour-induced osteomalacia and post-operative hungry bone syndrome.

Authors:
S Kumar T Diamond

Bone Rep 2020 Jun 6;12:100276. Epub 2020 May 6.

St George Public Hospital, Kogarah, NSW 2217, Australia.

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by a fibroblast growth-factor-23 (FGF-23)-secreting phosphaturic mesenchymal tumour (PMT) and is characterised by hypophosphataemic osteomalacia. We present a 36-year-old man initially presenting with diffuse bone and joint pain who was inappropriately treated for presumed ankylosing spondylitis for 2 years. Whole-body bone scan suggested metabolic bone disease, prompting referral to our endocrine institution. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235936PMC

Effect of Denosumab on Bone Mineral Density of Hematopoietic Stem Cell Transplantation Recipients.

Int J Endocrinol 2020 4;2020:3410921. Epub 2020 May 4.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: Denosumab is a monoclonal antibody that prevents the development of osteoclasts. The effect of denosumab in solid organ transplant recipients has been elucidated, but its effect in haematopoietic stem cell transplantation recipients has not been studied yet. The aim of this study was to determine the effectiveness and safety of denosumab in haematopoietic stem cell transplantation recipients. Read More

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http://dx.doi.org/10.1155/2020/3410921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218957PMC

Association of gender with serum potassium, sodium and calcium disorders after hypertensive intracerebral hemorrhage.

World Neurosurg 2020 May 23. Epub 2020 May 23.

Department of Neurosurgery, Heze Municipal Hospital, Heze 274031, China. Electronic address:

Objective: To determine the association of gender with serum potassium, sodium and calcium disorders in patients with hypertensive intracerebral hemorrhage, and meanwhile investigate other risk factors.

Methods: 516 patients with hypertensive intracerebral hemorrhage were retrospectively enrolled. The clinical characteristics were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.137DOI Listing

Quality Indicators of Central Compartment Neck Dissection in Thyroid Surgery.

Otolaryngol Head Neck Surg 2020 May 26:194599820925757. Epub 2020 May 26.

Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.

Objectives: Quality metrics are an increasingly important means of improving patient care. Variability in the number of lymph nodes removed during central compartment lymph node dissection (CCLND) at the time of thyroidectomy has not been studied.

Study Design: A retrospective cohort study was performed using American College of Surgeons National Quality Improvement Program (ACS-NSQIP) data. Read More

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http://dx.doi.org/10.1177/0194599820925757DOI Listing

Incidence and risk of tumor lysis syndrome in patients with relapsed chronic lymphocytic leukemia (CLL) treated with venetoclax in routine clinical practice.

Leuk Lymphoma 2020 May 25:1-6. Epub 2020 May 25.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

The risk of TLS in patients with relapsed CLL treated outside of clinical trials is not well described. Using the Mayo Clinic CLL Database, 48 patients treated with venetoclax for relapsed CLL in routine practice were identified; chart review determined baseline risk for TLS and laboratory abnormalities during venetoclax ramp-up. Overall, 6 (13%) patients developed laboratory TLS, 3 of whom demonstrated clinical TLS. Read More

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http://dx.doi.org/10.1080/10428194.2020.1768384DOI Listing

Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with NaEDTA.

J Vet Med Sci 2020 May 25. Epub 2020 May 25.

Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University.

This study was performed to confirm the alterations of blood and urine parameters in artificially induced hypocalcemic cows. For a 2 х 2 cross-over design, four non-pregnant, non-lactating Holstein Friesian cows (622.5 ± 63. Read More

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http://dx.doi.org/10.1292/jvms.20-0048DOI Listing

Negative dietary cation-anion difference and amount of calcium in prepartum diets: Effects on milk production, blood calcium, and health.

J Dairy Sci 2020 May 21. Epub 2020 May 21.

Department of Animal Sciences, University of Illinois, Urbana 61801. Electronic address:

Acidogenic prepartum diets with negative dietary cation-anion difference (DCAD) induce compensated metabolic acidosis, which stimulates calcium (Ca) mobilization before calving and decreases clinical and subclinical hypocalcemia postpartum. This strategy is often combined with limiting dietary Ca concentrations, which historically has been used to mobilize Ca prepartum to prepare cows for lactation. Supplemental dietary Ca in combination with a negative DCAD formulation that does not reverse the effect of compensated metabolic acidosis may be beneficial. Read More

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http://dx.doi.org/10.3168/jds.2019-18068DOI Listing

Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows.

J Dairy Sci 2020 May 21. Epub 2020 May 21.

Department of Animal Science, Iowa State University, Ames 50011. Electronic address:

Periparturient hypocalcemia is a common metabolic disorder and it is ostensibly associated with negative health and production outcomes. Acute infection also markedly decreases circulating Ca, but the reasons for and consequences of it on physiological and immunological parameters are unknown. Objectives were to evaluate the effects of maintaining eucalcemia on production, metabolic, and immune variables following an intravenous lipopolysaccharide (LPS) challenge. Read More

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http://dx.doi.org/10.3168/jds.2020-18268DOI Listing

Retrospective evaluation of 85 patients with urea cycle disorders: one center experience, three new mutations.

J Pediatr Endocrinol Metab 2020 May 24. Epub 2020 May 24.

Hacettepe University İhsan Doğramacı Children's Hospital, Ankara, Turkey.

Objectives Urea cycle disorders (UCDs) are rare hereditary diseases. This study was conducted to help identify the characteristics of UCDs in Turkey. Methods The primary outcome was to determine patient characteristics. Read More

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http://dx.doi.org/10.1515/jpem-2019-0413DOI Listing

Predicting Ionized Hypocalcemia in Critical Care: An Improved Method Based on the Anion Gap.

J Appl Lab Med 2020 Jan;5(1):4-14

Department of Medicine, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY.

Background: Low ionized calcium (ICa) is prevalent in critical care patients. It is poorly detected by the popular indirect method, which corrects serum total calcium (TCa) for change in albumin. That correction (cTCa) ignores any concomitant change in the anion-complexed fraction of TCa. Read More

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http://dx.doi.org/10.1373/jalm.2019.029314DOI Listing
January 2020

Intravenous iron supplementation therapy.

Mol Aspects Med 2020 May 19:100862. Epub 2020 May 19.

Medical University of Innsbruck, Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Anichstrasse 35, A-6020, Innsbruck, Austria. Electronic address:

Intravenous infusions of iron have evolved from a poorly effective and dangerous intervention to a safe cornerstone in the treatment of iron deficiency. Modern iron formulations are composite nanoparticles composed of carbohydrate ferric oxy-hydroxides. Iron dextran, iron derisomaltose (formely known as iron isomaltoside 1000), ferric carboxymaltose, ferrumoxytol, iron sucrose and sodium ferric gluconate can be infused at different doses and allow correction of total iron deficit with single or repeated doses in 1-2 weeks depending on the specific formulation. Read More

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http://dx.doi.org/10.1016/j.mam.2020.100862DOI Listing

[Hypoparathyroidism treated with recombinant human parathyroid hormone [rhPTH(1-84)]].

Medicina (B Aires) 2020 ;80(3):289-291

Servicio de Endocrinología, Clínica Universitaria Reina Fabiola, Córdoba, Argentina.

Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for papillary thyroid carcinoma (T3 N1b M0) two years before, who was referred to our clinic for symptomatic hypocalcemia. The patient reported serum calcium average levels of 7mg%, presented symptoms of hypocalcemia at rest and had multiple hospital admissions. Read More

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January 2020

Late-onset postsurgical hypoparathyroidism following parathyroidectomy for recurrent primary hyperparathyroidism: a case report and literature review.

Endocrine 2020 May 21. Epub 2020 May 21.

University Hospital of Pisa, Endocrine Unit 2, Pisa, Italy.

Purpose: Previously in 1987, a 21-year-old male was diagnosed with primary hyperparathyroidism (PHPT) when a right inferior parathyroid adenoma was removed. PHPT recurred after 3 and 6 years and on both occasions was cured by resection of parathyroid adenomas. At 52 years of age, the patient developed a late-onset hypoparathyroidism (HP), even though postsurgical HP typically occurs as a transient or permanent form soon after neck surgery. Read More

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http://dx.doi.org/10.1007/s12020-020-02344-yDOI Listing

The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism.

Arch Osteoporos 2020 May 19;15(1):75. Epub 2020 May 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

This study aims to evaluate factors affecting the quality of life (QOL) of hypoparathyroidism. While QOL is reduced in post-surgical and non-surgical groups, mental health seems to be less affected in non-surgical patients. Having an additional disease affects QOL negatively but having thyroid cancer may not change the QOL results. Read More

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http://dx.doi.org/10.1007/s11657-020-00759-8DOI Listing

Kenny-Caffey syndrome type 2.

QJM 2020 May 19. Epub 2020 May 19.

Dept of Biochemistry, Shree Narayana Institute of Medical Superspeciality, Nanded, Maharashtra, India.

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http://dx.doi.org/10.1093/qjmed/hcaa175DOI Listing

Impact of altered dietary calcium-phosphorus ratio caused by high-phosphorus diets in a rat chronic kidney disease (CKD) model created by partial ligation of the renal arteries.

J Toxicol Pathol 2020 Apr 3;33(2):77-86. Epub 2020 Jan 3.

Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 1-1-1 Sakura-ga-Oka, Setagaya, Tokyo 156-8502, Japan.

This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels for a period of 48 days. A marked suppression of body weight gain necessitating humane euthanization occurred on day 28 in rats that had undergone RL and were given high-phosphorus feed. Read More

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http://dx.doi.org/10.1293/tox.2019-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218233PMC

Impact of vitamin D deficiency on mouse spermatozoa structure and function.

Andrology 2020 May 18. Epub 2020 May 18.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Background: In rodents and humans, vitamin D deficiency (VDD) is associated with altered spermatozoa structure and function (primarily decreased motility and morphological abnormalities) that are primarily attributed to VDD-induced hypocalcemia. However, it is suspected that VDD has much more drastic effects on mammalian spermatozoa.

Objectives: The purpose of this study was to illustrate that VDD, depending on its severity and duration, can alter sperm nuclear integrity and can also lead to the loss of spermatozoa's ability to support embryonic development. Read More

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http://dx.doi.org/10.1111/andr.12820DOI Listing

Congenital hypoparathyroidism associated with elevated circulating non-functional PTH due to novel PTH mutation.

J Clin Endocrinol Metab 2020 May 18. Epub 2020 May 18.

Cancer Genetics, Kolling Institute of Medical Research, Sydney, NSW, Australia.

Context: Familial hypoparathyroidism has a heterogeneous presentation where patients usually have low parathyroid hormone (PTH) levels due to impaired production or secretion. This contrasts with pseudohypoparathyroidism in which PTH resistance is usually associated with an elevated serum PTH. High levels of circulating PTH can also be due to bio-inactive PTH, which is difficult to distinguish from pseudohypoparathyroidism on biochemical grounds. Read More

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http://dx.doi.org/10.1210/clinem/dgaa279DOI Listing

Surgery for retrosternal goiter: cervical approach.

Gland Surg 2020 Apr;9(2):392-400

Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

Background: Retrosternal goiter refers to when the thyroid gland extends from the neck to the substernal portion, descending below the thoracic inlet into the mediastinum. It is typically accompanied by compressive symptoms, and most patients need to undergo surgery. This retrospective study set out to analyze the surgical approach to retrosternal goiter and to evaluate perioperative complications, with the aim of recommending best surgical technique. Read More

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http://dx.doi.org/10.21037/gs.2020.03.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225497PMC

U-shaped strap muscle flap for difficult thyroid surgery.

Gland Surg 2020 Apr;9(2):372-379

School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.

Background: Open thyroidectomy via conventional midline approach can be challenging in complex thyroid surgeries. This study proposes a U-shaped strap muscle flap (USMF) technique that provides adequately wide exposure of the surgical field.

Methods: Strap muscles were cut close to the clavicle and along the anterior margin of both sternocleidomastoid muscles followed by total thyroidectomy in 20 patients as USMF group, and surgical outcomes were compared with 40 patients who had received total thyroidectomy via midline approach. Read More

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http://dx.doi.org/10.21037/gs.2020.02.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225498PMC

Therapeutic efficacy of two surgical methods on the secondary hyperparathyroidism.

Gland Surg 2020 Apr;9(2):321-328

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.

Background: This study aimed to investigate the clinical efficacy of two surgical methods on hyperparathyroidism secondary to uremia and summarize the advantages and disadvantages of both methods.

Methods: Uremic patients who received parathyroidectomy (PTX) in the last 3 years were divided into two groups according to the surgical methods used [subtotal parathyroidectomy (SPTX) group and total parathyroidectomy + autologous implantation (TPTX + AT) group]. TPTX was performed if less than 4 glands were found during surgery. Read More

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http://dx.doi.org/10.21037/gs.2020.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225472PMC

Influence of gender and women's age on the prevalence of parathyroid failure after total thyroidectomy for multinodular goiter.

Gland Surg 2020 Apr;9(2):245-251

Endocrine Surgery Unit, Hospital del Mar, Barcelona, Spain.

Background: Female gender, particularly of a young age, has been reported as a risk factor for hypocalcemia after total thyroidectomy. There are no studies, however, addressing specifically the influence of women's age and menstrual status on postoperative parathyroid function.

Methods: Cohort study of consecutive patients undergoing total thyroidectomy for benign goiter between 2000-2017, excluding those with associated hyperparathyroidism, reoperation or conservative procedures. Read More

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http://dx.doi.org/10.21037/gs.2020.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225482PMC

The effect of prepartum negative dietary cation-anion difference and serum calcium concentration on blood neutrophil function in the transition period of healthy dairy cows.

J Dairy Sci 2020 May 14. Epub 2020 May 14.

Population Medicine, University of Guelph, Guelph, ON, Canada, N1G 2W1.

Our objectives were to assess the effects of a diet with a negative dietary cation-anion difference (DCAD) before calving on phagocytosis (Pc) and oxidative burst (OB) function of circulating neutrophils, and to determine the associations of serum ionized (iCa) and total calcium (tCa) concentrations with Pc and OB in transition dairy cows. We hypothesized that multiparous cows fed a negative DCAD diet prepartum would have greater iCa and tCa, and thus improved Pc and OB. From 3 wk before expected parturition until calving, 38 healthy multiparous cows from 3 farms were assigned to negative DCAD treatment (TRT; -100 mEq/kg of diet dry matter; n = 21) or a control (CON; 95 mEq/kg of dry matter; n = 17) diet. Read More

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http://dx.doi.org/10.3168/jds.2019-18012DOI Listing

A Rare Case of Spontaneous Intrauterine Skull Fracture.

Acta Med Port 2020 May 4;33(5):344-346. Epub 2020 May 4.

Serviço de Ginecologia/Obstetrícia. Unidade Local de Saúde de Matosinhos. Hospital Pedro Hispano. Matosinhos. Portugal.

Skull fractures are rare in newborns and normally caused by maternal abdominal trauma or complicated deliveries. However, in rare cases, these fractures are found in neonates born after an uneventful pregnancy and delivery. We report a case of a primigravida who underwent cesarean delivery due to failure of descent and malpositioning of the fetal head. Read More

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http://dx.doi.org/10.20344/amp.11565DOI Listing

Clinical characteristics and immunological status of patients with 22q11.2 deletion syndrome in Northern Thailand.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: 22q11.2 deletion syndrome is one of the most prevalent microdeletion syndromes in humans. The syndrome is characterized by extensive phenotypic variability. Read More

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http://dx.doi.org/10.12932/AP-241019-0671DOI Listing

Bone and mineral metabolism in children with nephropathic cystinosis compared to other CKD entities.

J Clin Endocrinol Metab 2020 May 15. Epub 2020 May 15.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School Children's Hospital, Hannover, Germany.

Context: Children with nephropathic cystinosis (NC) show persistent hypophosphatemia, due to Fanconi syndrome, as well as mineral and bone disorders related to chronic kidney disease (CKD), but systematic analyses are lacking.

Objective: To compare biochemical parameters of bone and mineral metabolism between children with NC and controls across all stages of CKD.

Design: Cross-sectional multicenter study. Read More

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http://dx.doi.org/10.1210/clinem/dgaa267DOI Listing

Milk-alkali syndrome: a 'quick ease' or a 'long-lasting problem'.

Endocrinol Diabetes Metab Case Rep 2020 May 13;2020. Epub 2020 May 13.

Department of Endocrinology, Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia.

Summary: We report the case of a 65-year-old female who presented with symptomatic hypercalcaemia (corrected calcium of 4.57 mmol/L) with confusion, myalgias and abdominal discomfort. She had a concomitant metabolic alkalosis (pH 7. Read More

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http://dx.doi.org/10.1530/EDM-20-0028DOI Listing

C-terminal telopeptide of type I collagen, osteocalcin, alkaline phosphatase, and parathyroid hormone in healthy and hospitalized foals.

Domest Anim Endocrinol 2020 Jul 6;72:106470. Epub 2020 Mar 6.

College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Hypocalcemia is a common finding in critically ill equine patients. Parathyroid hormone (PTH) helps to maintain calcium homeostasis in hypocalcemic patients by promoting renal calcium reabsorption and bone resorption. Increased serum PTH concentrations have been reported in critically ill people and animals, including horses and foals. Read More

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http://dx.doi.org/10.1016/j.domaniend.2020.106470DOI Listing

The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status.

Horm Metab Res 2020 May 13. Epub 2020 May 13.

Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Primary aldosteronism (PA) was reported to frequently harbor not only cardiovascular diseases but also some metabolic disorders including secondary calcium metabolic diseases. Recently, the potential association between aldosterone producing cells and systemic calcium metabolism has been proposed. For instance, PA is frequently associated with hypercalciuria or hypocalcemia, which subsequently stimulates parathyroid hormone (PTH) secretion. Read More

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http://dx.doi.org/10.1055/a-1157-0511DOI Listing

Findings in cattle consigned to Victorian knackeries between 2009 and 2018.

Aust Vet J 2020 May 12. Epub 2020 May 12.

Department of Jobs, Precincts and Regions, 475 Mickleham Road, Attwood, Victoria, 3049, Australia.

Objective: To describe the causes of death or culling in cattle in Victoria, Australia, through surveillance at knackeries.

Methods: Data were collected from 2797 adult cattle consigned to four Victorian knackeries over a 10-year period (2009-2018, inclusive). Cattle were sampled either at the point of collection or at a knackery. Read More

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http://dx.doi.org/10.1111/avj.12956DOI Listing

Manifestations of left ventricular dysfunction and arrhythmia in patients with chronic hypoparathyroidism and pseudohypoparathyroidism: a preliminary study.

BMC Endocr Disord 2020 May 11;20(1):61. Epub 2020 May 11.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Dongcheng District, Shuaifuyuan No.1, Beijing, 100730, China.

Background: Cardiac damage triggered by severe hypocalcemia is well known. However, the role of chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) in cardiac health is still unclear. We investigated the effect of chronic HP and PHP on cardiac structure and conductive function in patients compiling with treatment. Read More

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http://dx.doi.org/10.1186/s12902-020-0541-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216721PMC

Clinical Presentation and Surgical Treatment of Retrosternal Goiter: A Case Series Study.

Qatar Med J 2020 4;2020(1):13. Epub 2020 May 4.

Clinical Research, Trauma & Vascular Surgery Section, Hamad General Hospital (HGH), Doha, Qatar.

The retrosternal goiter (RSG) is a slow-growing mass often benign in nature; thyroidectomy remains the preferred standard curative treatment. This study aimed to explore the local experience of RSG with respect to the clinical presentation, classifications, management, and outcomes. A retrospective chart review was conducted to include all cases diagnosed with RSG and underwent thyroidectomy between January 1998 and December 2013. Read More

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http://dx.doi.org/10.5339/qmj.2020.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198470PMC

Familial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population.

Am J Hum Genet 2020 Apr 29. Epub 2020 Apr 29.

Regeneron Genetics Center, Tarrytown, NY 10591, USA.

The calcium-sensing receptor (CaSR) regulates serum calcium concentrations. CASR loss- or gain-of-function mutations cause familial hypocalciuric hypercalcemia type 1 (FHH1) or autosomal-dominant hypocalcemia type 1 (ADH1), respectively, but the population prevalence of FHH1 or ADH1 is unknown. Rare CASR variants were identified in whole-exome sequences from 51,289 de-identified individuals in the DiscovEHR cohort derived from a single US healthcare system. Read More

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http://dx.doi.org/10.1016/j.ajhg.2020.04.006DOI Listing

Optic disc drusen: a systematic review : Up-to-date and future perspective.

Int Ophthalmol 2020 May 7. Epub 2020 May 7.

Department of Biomedical Science, Humanitas University, 20090, Pieve Emanuele, Milano, Italy.

Background: Optic disc drusen (ODD) are acellular deposits in the prelaminar optic nerve head. The most accredited theory is that they are secondary to abnormalities in axonal metabolism and degeneration, but the pathogenesis is not clear to date.

Clinical Manifestation: Although ODD are often considered a benign condition, the great majority of patients with ODD show visual field defects and are at higher risk for developing anterior ischemic optic neuropathy. Read More

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http://dx.doi.org/10.1007/s10792-020-01365-wDOI Listing

[Endocrine Dysfunction Associated with Immune Checkpoint Blockade].

Authors:
Shintaro Iwama

Gan To Kagaku Ryoho 2020 Feb;47(2):203-206

Dept. of Endocrinology and Diabetes, Nagoya University Hospital.

Immune checkpoint inhibitors(ICIs)have been widely used in patients with advanced malignancies. However, these drugs can cause immune-related adverse events(irAEs)in several organs, including lung, skin, gastrointestinal tract, liver, nerve, muscle, and endocrine organs. Endocrine irAEs include hypopituitarism, primary adrenal insufficiency, thyroid dysfunction, hypoparathyroidism, and type 1 diabetes mellitus, which can result in life-threatening consequences, such as adrenal crisis, thyroid storm, severe hypocalcemia, and diabetic ketoacidosis. Read More

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February 2020

Hypocalcaemia predicts 12-month re-hospitalization in heart failure.

Eur J Clin Invest 2020 May 6:e13261. Epub 2020 May 6.

Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng, China.

Background: Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12-month clinical outcome in the disease.

Materials And Methods: A total of 350 patients with newly diagnosed HFpEF were included in this prospective observational study. Read More

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http://dx.doi.org/10.1111/eci.13261DOI Listing

Cinacalcet use in pediatric chronic kidney disease. A survey study.

Saudi Med J 2020 May;41(5):479-484

Department of Pediatrics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the practice and attitude of pediatrics nephrologists about cinacalcet use in children.

Methods: An electronic structured questionnaire was answered by pediatric nephrologists practicing in the Kingdom of Saudi Arabia (KSA) and Gulf Council countries (GCC).

Results: A total of 42  pediatric nephrologists responded, of them, 42% used cinacalcet for young children ≤5 years of age and 79% used for children. Read More

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http://dx.doi.org/10.15537/smj.2020.5.25072DOI Listing