6,493 results match your criteria Hypoalbuminemia


Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study.

BMC Palliat Care 2020 Jul 1;19(1):94. Epub 2020 Jul 1.

Department of Family Medicine, Yonsei University Graduate School of Medicine, 211 Eonju-ro, Dogok-dong, Gangnam-gu, Seoul, Republic of Korea.

Background: Although palliative care providers, patients, and their families rely heavily on accurate prognostication, the prognostic value of electrolyte imbalance has received little attention.

Methods: As a retrospective review, we screened inpatients with terminal cancer admitted between January 2017 and May 2019 to a single hospice-palliative care unit. Clinical characteristics and laboratory results were obtained from medical records for multivariable Cox regression analysis of independent prognostic factors. Read More

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http://dx.doi.org/10.1186/s12904-020-00607-zDOI Listing

Usefulness of Carnitine Supplementation for the Complications of Liver Cirrhosis.

Nutrients 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.

Carnitine is a vitamin-like substance that regulates lipid metabolism and energy production. Carnitine homeostasis is mainly regulated by dietary intake and biosynthesis in the organs, including the skeletal muscle and the liver. Therefore, liver cirrhotic patients with reduced food intake, malnutrition, biosynthetic disorder, and poor storage capacity of carnitine in the skeletal muscle and liver are more likely to experience carnitine deficiency. Read More

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http://dx.doi.org/10.3390/nu12071915DOI Listing

Ultrasonographic features and prevalence of presumed gastric wall edema in dogs with hypoalbuminemia.

J Vet Intern Med 2020 Jul 1. Epub 2020 Jul 1.

Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA.

Background: Ultrasonographic features of gastric wall edema have not been reported in dogs with hypoalbuminemia.

Objectives: To describe the prevalence and ultrasonographic features of gastric wall thickening in dogs with hypoalbuminemia and analyze correlation with serum albumin concentrations.

Animals: Forty-two dogs with abdominal ultrasound and diagnosis of hypoalbuminemia (<2. Read More

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http://dx.doi.org/10.1111/jvim.15829DOI Listing

DVT incidence and risk factors in critically ill patients with COVID-19.

J Thromb Thrombolysis 2020 Jun 30. Epub 2020 Jun 30.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with thrombosis prophylaxis. This study retrospectively included 88 patients in the ICU with critically ill COVID-19 at Jinyintan Hospital in Wuhan, China. All patients underwent compression ultrasonography for identifying DVT. Read More

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http://dx.doi.org/10.1007/s11239-020-02181-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324310PMC

Risk and impact of invasive fungal infections in patients with multiple myeloma.

Ann Hematol 2020 Jul 1. Epub 2020 Jul 1.

Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201 Shipai Road, Sec. 2, Taipei, 11217, Taiwan.

Infection is associated with great morbidity and mortality in patients with multiple myeloma (MM), but evidence for invasive fungal infections (IFIs) is lacking. We aimed to investigate risk factors for IFI in MM patients and to determine its impact on patients' survival. We retrospectively analyzed MM patients at Taipei Veterans General Hospital in Taiwan between January 2002 and October 2018. Read More

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http://dx.doi.org/10.1007/s00277-020-04125-zDOI Listing

Pilot prospective study of Frailty and Functionality in routine clinical assessment in allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Section of Medical Oncology and Hematology, University of Toronto, Toronto, ON, Canada.

A Frailty and Functionality evaluation for alloHCT was implemented using existing resources. We describe the implementation of this evaluation across all ages and at first consultation, and correlate results with posttransplant outcomes in 168 patients. The evaluation consists of: Clinical Frailty Scale (CFS), Instrumental Activities of Daily Living (IADL), grip strength (GS), timed up and go test (TUGT), self-rated health question (SRH), Single question of Falls, albumin and C-Reactive Protein (CRP) levels. Read More

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http://dx.doi.org/10.1038/s41409-020-0979-1DOI Listing
June 2020
3.570 Impact Factor

Relationship between Modified Body Mass Index and Prognosis of Renal Amyloid a Amyloidosis.

Sisli Etfal Hastan Tip Bul 2018 4;52(2):103-108. Epub 2018 Jun 4.

Department of Nephrology, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Objectives: Overhydration occurs in nephrotic syndrome related to kidney involvement of amyloid A (AA) amyloidosis, which can cause an overestimation of body mass index (BMI). Modified BMI (mBMI, albumin×BMI) may be a better marker of nutritional status; therefore, we investigated the relationship between mBMI and the prognosis of patients with renal AA amyloidosis.

Methods: We retrospectively reviewed the data of patients with biopsy-proven renal AA amyloidosis who were followed up between January 2001 and May 2013. Read More

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http://dx.doi.org/10.14744/SEMB.2017.89410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315068PMC

Clinical and Epidemiological Features of SARS-CoV-2 Patients in SARI Ward of a Tertiary Care Centre in New Delhi.

J Assoc Physicians India 2020 Jul;68(7):19-26

Postgraduate Student (Medicine), ABVIMS and Dr Ram Manohar Lohia Hospital, New Delhi.

Importance: Rapid spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Wuhan, China, prompted heightened surveillance in India. Since the first laboratory confirmed case of SARS-CoV-2 was reported from Kerala on January 30, 2020 novel coronavirus infected pneumonia (NCIP) has been presenting to the hospital emergencies as severe acute respiratory illness (SARI). We aim to find out the rate of SARS-CoV-2 positivity in SARI cases and further clarify the epidemiological and clinical characteristics of NCIP in New Delhi, India. Read More

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Nutritional management of celiac crisis in an elderly adult: A case report of the rare presentation of celiac disease in a 75-y-old woman.

Nutrition 2020 May 19;79-80:110858. Epub 2020 May 19.

Unit of Dietetic and Clinical Nutrition, University Hospital Maggiore della Carità, Novara, Italy.

In adults, a very uncommon presentation of celiac disease (CD) is a celiac crisis, a life-threatening and severe form of the disease having a dramatic onset with diarrhea and metabolic acidosis with electrolyte and fluid imbalance. Treatment of celiac crisis requires a gluten-free diet; however, the risk for refeeding syndrome (RFS) should be considered in patients showing marked malabsorption symptoms and important unintentional weight loss. Therefore, to avoid metabolic and potentially fatal complications of re-nutrition, nutritional management is crucial for a safe recovery after a celiac crisis. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110858DOI Listing

Commentary on 'Preoperative hypoalbuminemia is an independent risk factor for postoperative complications in Crohn's disease patients with normal BMI: A cohort study'.

Authors:
Meer M Chisthi

Int J Surg 2020 Jun 26;80:49-50. Epub 2020 Jun 26.

Department of General Surgery, Government Medical College, Trivandrum, Kerala, 695011, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.06.033DOI Listing

Preoperative Nutritional Status Predicts Major Morbidity After Primary Rectal Cancer Resection.

J Surg Res 2020 Jun 25;255:325-331. Epub 2020 Jun 25.

Department of Surgery, Sinai Hospital of Baltimore, Baltimore, Maryland.

Background: Malnutrition has been associated with adverse surgical outcomes, but data regarding its impact specifically in rectal cancer are sparse. The goal of this study was to use national data to determine the effects of malnutrition on surgical outcomes in rectal cancer resection.

Methods: Data were obtained from the American College of Surgeons National Surgical Quality Initiative Program from the years 2012-2015. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.081DOI Listing

Effects of hepatic arterial infusion chemotherapy in the treatment of hepatocellular carcinoma: A meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20745

Hepatic Biliary Pancreatic Surgery Department, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China.

Background: The potential benefits and safety of hepatic arterial infusion chemotherapy (HAIC) for the treatment of patients with hepatocellular carcinoma (HCC) remains inconsistent. Therefore, we conducted this meta-analysis of evaluate the efficacy and safety of HAIC in the treatment of HCC.

Methods: A comprehensive literature search was performed using PubMed, Embase, Web of Science, and the Cochrane library to identify eligible studies that compared HAIC with other therapies for patients with HCC. Read More

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http://dx.doi.org/10.1097/MD.0000000000020745DOI Listing

Estimation of homeostatic dysregulation and frailty using biomarker variability: a principal component analysis of hemodialysis patients.

Sci Rep 2020 Jun 25;10(1):10314. Epub 2020 Jun 25.

Division of Nephrology, Yuai Clinic, Hakuyukai Medical Corporation, Saitama-City, Saitama, Japan.

Increased intraindividual variability in several biological parameters is associated with aspects of frailty and may reflect impaired physiological regulation. As frailty involves a cumulative decline in multiple physiological systems, we aimed to estimate the overall regulatory capacity by applying a principal component analysis to such variability. The variability of 20 blood-based parameters was evaluated as the log-transformed coefficient of variation (LCV) for one year's worth of data from 580 hemodialysis patients. Read More

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http://dx.doi.org/10.1038/s41598-020-66861-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316742PMC

Preliminary study of Cytauxzoon felis infection in outdoor cats in Mashhad, Iran.

Parasitol Res 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

The objectives of the current study were to assess the preliminary status of Cytauxzoon felis (C. felis) infection among outdoor cats in Mashhad, Iran and also to compare clinicopathological findings between C. felis infected and non-infected cats. Read More

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http://dx.doi.org/10.1007/s00436-020-06780-7DOI Listing

Prediction Rule for Scrub Typhus Meningoencephalitis in Children: Emerging Disease in North India.

J Child Neurol 2020 Jun 25:883073820933148. Epub 2020 Jun 25.

Department of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Objectives: To evaluate the proportion of scrub typhus meningoencephalitis among children with acute encephalitis syndrome and to outline its differentiating features. To develop a prediction rule for scrub typhus meningoencephalitis.

Methods: A prospective cohort study was conducted at a tertiary care public hospital in Northern India. Read More

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http://dx.doi.org/10.1177/0883073820933148DOI Listing

Low Serum Albumin Levels are Associated with Increased 30-Day Cardiopulmonary Complications, Reoperation, and Readmission Rates Following Total Shoulder Arthroplasty.

Iowa Orthop J 2019 ;39(2):27-34

Department of Orthopaedic Surgery; The George Washington University.

Background: Hypoalbuminemia has been associated with several medical complications following surgery in a variety of orthopedic procedures. Hypoalbuminemia has previously been shown to have an increased risk for transfusions, hospital stay longer than three days, and mortality following total shoulder arthroplasty (TSA). This study seeks to further assess the relationship between low serum albumin and morbidity to allow surgeons to both preoperatively optimize patients and assess the risk of surgery prior to TSA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047290PMC
January 2019

Concomitant Malnutrition and Frailty Are Uncommon, but Significant Risk Factors for Mortality and Complication Following Primary Total Knee Arthroplasty.

J Arthroplasty 2020 Jun 1. Epub 2020 Jun 1.

Department of Orthopaedic Surgery, Atlanta, GA.

Background: Total knee arthroplasty (TKA) demand continues to rise, but we are also gaining greater insight into patient risk factors for postoperative complications and excess resource utilization. There has been growing interest in frailty and malnutrition as risk factors, although they are often mistakenly used interchangeably. We aimed at identifying the incidence of their coexistence, and the magnitude of risk they confer to TKA patients. Read More

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http://dx.doi.org/10.1016/j.arth.2020.05.062DOI Listing

No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery.

J Trauma Acute Care Surg 2020 Jul;89(1):230-237

From the Division of Trauma, Emergency Surgery, and Surgical Critical Care (N.N., J.H., M.K., J.M.L., N.K., G.V., D.K., P.F., N.S., A.M., M.R., H.M.A.K.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Surgery (N.N.), and Department of Anesthesiology (M.K.), Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand; and Center for Outcomes and Patient Safety in Surgery (H.M.A.K.), Massachusetts General Hospital, Boston, Massachusetts.

Background: Outcome data on the very elderly patients undergoing emergency general surgery (EGS) are sparse. We sought to examine short- and long-term mortality in the 80 plus years population following EGS.

Methods: Using our institutional 2008-2018 EGS Database, all the 80 plus years patients undergoing EGS were identified. Read More

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http://dx.doi.org/10.1097/TA.0000000000002696DOI Listing

Hypoalbuminemia as a predictor of mortality in abdominal sepsis.

Cir Cir 2020 ;88(4):481-484

Servicio de Cirugía General, Hospital Ángeles MOCEL, Ciudad de México, México.

Background: A level < 35 g/L of albumin (hypoalbuminemia) has been determined as a parameter to predict mortality and morbidity.

Method: Prospective observational study, in a period of 12 months, to patients diagnosed with sepsis of abdominal origin, they are divided into two groups based on albumin levels (cut: 3.5 g/dL) to assess mortality between both groups. Read More

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http://dx.doi.org/10.24875/CIRU.20001712DOI Listing
January 2020

Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases.

Sci China Life Sci 2020 Jun 18. Epub 2020 Jun 18.

Division of Cardiology, Department of Internal Medicine, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, China.

Coronavirus disease 2019 (COVID-19) is a global pandemic which has caused numerous deaths worldwide. The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of COVID-19 patients. In this retrospective study, we extracted data from 2,623 clinically confirmed adult COVID-19 patients (>18 years old) between January 29, 2020 and March 6, 2020 in Tongji Hospital, Wuhan, China. Read More

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http://dx.doi.org/10.1007/s11427-020-1733-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306450PMC

A Rare Case of Splenic in a HIV-Positive Patient.

Case Rep Gastrointest Med 2020 10;2020:8509591. Epub 2020 Jun 10.

Department of Medicine, BronxCare Hospital Center, Bronx, NY 10457, USA.

Introduction: Human immunodeficiency virus (HIV) positive individuals with the CD4 count less than 200 cells/mm are at risk for opportunistic infections. , a fungal pathogen, is a common cause of opportunistic infections with predominantly pulmonary involvement. Disseminated infection presenting with hepatosplenic lesion is extremely rare. Read More

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http://dx.doi.org/10.1155/2020/8509591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303748PMC

Acute pancreatic injuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immune cell activation.

J Am Acad Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Electronic address:

Background: Complications involving internal organs are usually present in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, pancreatic complications are rarely reported and studied.

Objective: To summarize clinical characteristics of SJS/TEN-associated acute pancreatic injuries (API) and to investigate underlying inflammatory mechanisms. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297678PMC

Comparison of the diagnostic performance of microscopic examination, Copro-ELISA, and Copro-PCR in the diagnosis of Capillaria philippinensis infections.

PLoS One 2020 17;15(6):e0234746. Epub 2020 Jun 17.

Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Intestinal capillariasis is a parasitic zoonosis caused by the tiny nematode parasite Capillaria philippinensis. It is a major health problem that may lead to death if not diagnosed and treated appropriately. The difficulties in the diagnosis of C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234746PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299379PMC

The Copper/Zinc Ratio Correlates With Markers of Disease Activity in Patients With Inflammatory Bowel Disease.

Crohns Colitis 360 2020 Jan 23;2(1):otaa001. Epub 2020 Jan 23.

Department of Gastroenterology and Hepatology, Clarunis, Basel, Switzerland.

Background: Zinc (Zn) and copper (Cu) are trace elements that serve as cofactors in catalytic processes with impact on immune responses. In patients with inflammatory bowel disease (IBD), decreased levels of serum Zn and Cu have been observed. Here, we investigated the effect of inflammation on serum concentrations of these trace elements in patients with IBD. Read More

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http://dx.doi.org/10.1093/crocol/otaa001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291944PMC
January 2020

Case Report on Paediatric Nephrotic Syndrome.

EJIFCC 2020 Jun 2;31(2):164-168. Epub 2020 Jun 2.

Department of Paediatrics, Malla Reddy Institute of Medical Sciences, Secunderabad, Telangana, India.

Nephrotic syndrome (NS) is a glomerular disorder typically characterized by gross proteinuria, hypoalbuminemia, hyperlipidemia, and peripheral oedema. We report the case of a 2-year-old male toddler weighing 15 kg with a 1-week history of swelling around the eyes and both legs, and generalized body swelling. She had a history of fever, cough and decreased urine output. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294819PMC

The effect of giving fish extract (Pujimin Plus) on intake of protein and hemoglobin hypoalbuminemic patients.

Enferm Clin 2020 Jun;30 Suppl 4:452-455

Nutrition Department, Public Health, Hasanuddin University, Indonesia.

Objective: This study aimed to determine the effect of cork extract on albumin levels and protein intake in hypoalbuminemic patients at Wahidin Sudirohusodo Hospital.

Methods: This study was a quasi-experimental study with a randomized controlled trial (RCT) design, then divided into 2 intervention and control groups each consisting of 17 people.

Results: Data analysis showed that albumin level of intervention group 2. Read More

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http://dx.doi.org/10.1016/j.enfcli.2020.03.009DOI Listing

A patient specific forecasting model for human albumin based on deep neural networks.

Comput Methods Programs Biomed 2020 Jun 6;196:105555. Epub 2020 Jun 6.

Department of Mathematics, University of South Carolina, Columbia, SC 29208, USA. Electronic address:

Background And Objectives: Hypoalbuminemia can be life threatening among critically ill patients. In this study, we develop a patient-specific monitoring and forecasting model based on deep neural networks to predict concentrations of albumin and a set of selected biochemical markers for critically ill patients in real-time.

Methods: Under the assumption that metabolism of a patient follows a patient-specific dynamical process that can be determined from sufficient prior data taken from the patient, we apply a machine learning method to develop the patient-specific model for a critically ill, poly-trauma patient. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105555DOI Listing

HIV infection does not increase 10-week mortality of Chinese cryptococcal meningitis patients.

AIDS Res Hum Retroviruses 2020 Jun 16. Epub 2020 Jun 16.

The First Affiliated Hospital, School of Medicine, Zhejiang University, Infectious Diseases Department, 79 Qing Chun Road, 79 Qing Chun Road, Hangzhou, Zhejiang, China, 310006.

Backgroud The role of HIV infection in precipitating different clinical features in Cryptococcal meningitis (CM) patients remains controversial. Methods One hundred and twelve CM patients living with HIV/AIDS (CM+HIV+ patients) and 112 CM patients living without HIV/AIDS (CM+HIV- patients) were enrolled after propensity score matching. Demographic characteristics, symptoms, routine blood tests, biochemical and cerebrospinal fluid (CSF) profiles were compared between the two groups. Read More

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http://dx.doi.org/10.1089/AID.2020.0001DOI Listing

A rare case of nephrotic syndrome associated with Dent's disease: a case report.

CEN Case Rep 2020 Jun 12. Epub 2020 Jun 12.

Department of Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba-shi, Chiba, 260-8677, Japan.

Dent's disease is a rare X-linked condition caused by a mutation in CLCN5 and OCRL gene, which impair the megalin-cubilin receptor-mediated endocytosis in kidney's proximal tubules. Thus, it may manifest as nephrotic-range low-molecular-weight proteinuria (LMWP). On the other hand, glomerular proteinuria, hypoalbuminemia, and edema formation are the key features of nephrotic syndrome that rarely found in Dent's disease. Read More

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http://dx.doi.org/10.1007/s13730-020-00491-9DOI Listing

Population attributable risk estimates of risk factors for contrast-induced acute kidney injury following coronary angiography: a cohort study.

BMC Cardiovasc Disord 2020 Jun 12;20(1):289. Epub 2020 Jun 12.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Contrast-induced acute kidney injury (CI-AKI) is a common complication with poor outcomes following coronary angiography (CAG) or percutaneous coronary intervention (PCI). However, no study has explored the population attributable risks (PARs) of the CI-AKI risk factors. Therefore, we aimed to identify the independent risk factors of CI-AKI and estimate their PARs. Read More

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http://dx.doi.org/10.1186/s12872-020-01570-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291532PMC

Zinc Monotherapy as an Alternative Treatment Option for Decompensated Liver Disease due to Wilson Disease?

Case Reports Hepatol 2020 14;2020:1275940. Epub 2020 Jan 14.

Mekelle University, College of Health Science, Clinical Pharmacist, Tigray, Ethiopia.

Background: Wilson disease is a rare metabolic disorder involving copper metabolism, and patients may present with a variable degree of hepatic, neurologic, and psychiatric manifestations. In the case of hepatic presentation, treatment is usually initiated with potentially toxic copper chelators (D-penicillamine or Trenton). Although zinc is of low toxicity and low cost for treatment of Wilson disease, it has been limited to the adjunctive as a single maintenance drug or for asymptomatic patients. Read More

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http://dx.doi.org/10.1155/2020/1275940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201455PMC
January 2020

Hypoalbuminaemia in COVID-19 infection: A predictor of severity or a potential therapeutic target?

J Med Virol 2020 Jun 10. Epub 2020 Jun 10.

School of Clinical Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/jmv.26151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307076PMC

Radiotherapy followed by DICEP regimen in treatment of newly diagnosed, stage IE/IIE, extranodal NK/T-cell lymphoma patients.

Cancer Med 2020 Jun 9. Epub 2020 Jun 9.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: The optimal treatment strategies for extranodal natural killer/ T-cell lymphoma (ENKTL) have not been defined. We conducted this prospective, open-label, phase II, single-center study aimed to explore the efficacy and safety of radiotherapy followed by DICEP (Dexamethasone, ifosfamide, cisplatin, etoposide, and pegaspargase) regimen in the treatment of patients with untreated, stage IE/IIE, extranodal NK/T-cell lymphoma.

Methods: Thirty eligible patients were enrolled in this study, receiving radiotherapy of 50Gy/25fx, and followed by chemotherapy with DICEP regimen for 3 cycles if tolerated. Read More

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http://dx.doi.org/10.1002/cam4.3207DOI Listing

The impact of preoperative nutritional status on post-surgical complication and mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review of the literature.

World J Urol 2020 Jun 9. Epub 2020 Jun 9.

Department of Urology, Luzerner Kantonsspital, Lucerne, Switzerland.

Purpose: To investigate the impact of preoperative nutritional factors [body mass index (BMI)], hypoalbuminemia (< 3.5 g/dL, sarcopenia) on complication and mortality rates after radical cystectomy (RC) for bladder cancer.

Methods: The PubMed database was systematically searched for studies investigating the effect of nutritional status on postoperative outcomes after RC. Read More

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http://dx.doi.org/10.1007/s00345-020-03291-zDOI Listing

Effects of Albumin Infusion on Serum Levels of Albumin, Proinflammatory Cytokines (TNF-, IL-1, and IL-6), CRP, and MMP-8; Tissue Expression of EGRF, ERK1, ERK2, TGF-, Collagen, and MMP-8; and Wound Healing in Sprague Dawley Rats.

Int J Inflam 2020 20;2020:3254017. Epub 2020 May 20.

Department of Plastic Reconstructive & Aesthetic Surgery, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

In this study, we sought to determine the roles of albumin in wound healing, which is infused both pre- and postoperatively in malnourished patients presenting with hypoalbuminemia. For the purposes of the study, we used 25 male Sprague Dawley rats of predetermined weight and age, which were initially maintained in a standard environment and fed the same diet for 7 days prior to being segregated into one of the following five groups: A, control, normal protein feed (20% casein); B, hypoalbuminemia, 25% rat albumin infusion prior to surgery; C, hypoalbuminemia, normal protein feed (20% casein); D, hypoalbuminemia, 25% rat albumin infusion after surgery; and E, hypoalbuminemia, low-protein feed (casein 2%). The animals in all five groups were subjected to four deep incisions in their dorsal muscle fascia. Read More

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http://dx.doi.org/10.1155/2020/3254017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256723PMC

Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes-a cross-sectional study.

BMC Geriatr 2020 Jun 9;20(1):200. Epub 2020 Jun 9.

Muta Hospital, 3-9-1 Hoshikuma, Sawara-ku, Fukuoka, 814-0163, Japan.

Background: Frailty is broadly characterized by vulnerability and decline in physical, mental and social activities and is more common in elderly patients with type 2 diabetes mellitus (T2DM). Frailty is closely associated with nutrition, muscle strength, inflammation, and hormones etc. In hormones, dehydroepiandrosterone sulfate (DHEA-S) and cortisol are suggested to be such candidates affecting frailty. Read More

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http://dx.doi.org/10.1186/s12877-020-01601-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285748PMC

Final Results from a Phase II Trial of Osimertinib for Elderly Patients with Epidermal Growth Factor Receptor t790m-Positive Non-Small Cell Lung Cancer That Progressed during Previous Treatment.

J Clin Med 2020 Jun 5;9(6). Epub 2020 Jun 5.

Department of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used for treating EGFR-mutated lung cancer, and osimertinib is effective in cases that acquired T790M mutations after treatment with the first- and second-generation EGFR-TKIs. However, no study has evaluated its safety and efficacy in older patients. This phase II trial (jRCTs071180002) evaluated osimertinib in T790M mutation-positive Japanese patients who were ≥75 years old and had experienced relapse or progression after previous EGFR-TKI treatment. Read More

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http://dx.doi.org/10.3390/jcm9061762DOI Listing

Infection Control Precautions and Care Delivery in Hemodialysis Unit during Coronavirus Disease 2019 Outbreak: A Case Series.

Blood Purif 2020 Jun 5:1-8. Epub 2020 Jun 5.

Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China,

Background: With an estimated basic reproductive number of 3.77, the Coronavirus Disease 2019 (COVID-19) continues to spread. It is urgent to exert adequate efforts for the management of dialysis patients, caregivers, and healthcare personnel (HCP). Read More

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http://dx.doi.org/10.1159/000507876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316656PMC

Preoperative hypoalbuminemia is an independent risk factor for postoperative complications in Crohn's disease patients with normal BMI: A cohort study.

Int J Surg 2020 Jun 4;79:294-299. Epub 2020 Jun 4.

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:

Background: Malnutrition is universal in Crohn's disease (CD). The body mass index (BMI) is used to assess nutritional status to predict postoperative complications in CD patients. However, some CD patients have a normal BMI. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.05.064DOI Listing

Predicting tumor-specific survival in patients with spinal metastatic renal cell carcinoma: which scoring system is most accurate?

J Neurosurg Spine 2020 Jun 5:1-11. Epub 2020 Jun 5.

Departments of1Neurosurgery.

Objective: Although several prognostic scores for spinal metastatic disease have been developed in the past 2 decades, the applicability and validity of these models to specific cancer types are not yet clear. Most of the data used for model formation are from small population sets and have not been updated or externally validated to assess their performance. Developing predictive models is clinically relevant as prognostic assessment is crucial to optimal decision-making, particularly the decision for or against spine surgery. Read More

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http://dx.doi.org/10.3171/2020.4.SPINE20173DOI Listing

Clinical practice guidelines for Clostridioides (Clostridium) difficile infection and fecal microbiota transplant protocol - recommendations of the Polish Society od Epidemiology and Infectious Diseases.

Przegl Epidemiol 2020 ;74(1):69-87

Regional Hospital in Kielce and The Jan Kochanowski University in Kielce, Infectious Diseases Department.

Symptomatic Clostridium difficile infection (CDI) is an acute inflammatory disease of the gastrointestinal tract, manifesting in at least 3 unformed stools within 24 hours. Predicting factors for CDI include contact with medical care (mainly hospitalization), antibiotic therapy in the last 12 weeks, use of proton pump inhibitors (PPI), H2 blockers, cancer chemotherapy, especially in the neutropenia stage, gastrointestinal surgery, advanced age and concomitant chronic diseases (renal failure, liver failure, chronic inflammatory bowel disease - especially ulcerative bowel disease, cancer, HIV infection, cachexia and hypoalbuminaemia) and vitamin D deficiency. Clinical classification distinguishes three types of CDI - mild / moderate, severe, and fulminant. Read More

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http://dx.doi.org/10.32394/pe.74.06DOI Listing
January 2020

[i]Clostridioides difficile[/i] infection in patients with end stage renal disease. Is it preventable?

Przegl Epidemiol 2020 ;74(1):11-21

Research and Development Center, Provincial Specialist Hospital in Wroclaw, Poland.

[i]Clostridioides difficile[/i] infection (CDI) is a leading cause of a healthcare-associated diarrhea worldwide. Recently, an increased number of new cases and growing mortality due to CDI have been observed. Patients suffering from end-stage renal disease (ESRD) are most exposed to CDI. Read More

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http://dx.doi.org/10.32394/pe.74.02DOI Listing
January 2020

Significant morbidity is associated with proximal fecal diversion among high-risk patients who undergo colectomy: A NSQIP analysis.

Am J Surg 2020 May 18. Epub 2020 May 18.

Department of Surgery, University of Kentucky Medical Center, Lexington, KY, USA; Markey Cancer Center, University of Kentucky Medical Center, Lexington, KY, USA.

Background: The value of proximal fecal diversion for patients undergoing colectomies is an ongoing debate. Previous studies have shown a benefit in decreased anastomotic leak rates and mitigation of the morbidity of a leak, especially in high-risk populations. However, more recent data suggests increased morbidity with fecal diversion, creating a complication with an unknown degree of anastomotic leak reduction. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.05.007DOI Listing

Obesity and hypoalbuminaemia are independent risk factors for readmission and reoperation following primary total knee arthroplasty.

Bone Joint J 2020 Jun;102-B(6_Supple_A):31-35

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aims: Rates of readmission and reoperation following primary total knee arthroplasty (TKA) are under scrutiny due to new payment models, which penalize these negative outcomes. Some risk factors are more modifiable than others, and some conditions considered modifiable such as obesity may not be as modifiable in the setting of advanced arthritis as many propose. We sought to determine whether controlling for hypoalbuminaemia would mitigate the effect that prior authors had identified in patients with obesity. Read More

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http://dx.doi.org/10.1302/0301-620X.102B6.BJJ-2019-1509.R1DOI Listing

Near-fatal poisoning after ricin injection.

Clin Toxicol (Phila) 2020 Jun 1:1-11. Epub 2020 Jun 1.

Campinas Poison Control Center, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

To report a near-fatal poisoning after intentional injection of ricin from a castor bean () extract. A 21 year-old man self-injected ∼3 mL of a castor bean extract intramuscularly and subcutaneously in the left antecubital fossa. Upon admission to our ED (1 h post-exposure; day 1, D1) he was awake and alert, but complained of mild local pain and showed slight local edema and erythema. Read More

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http://dx.doi.org/10.1080/15563650.2020.1771358DOI Listing
June 2020
3.122 Impact Factor

Personalized Preoperative Nomograms Predicting Postoperative Risks after Resection of Perihilar Cholangiocarcinoma.

World J Surg 2020 May 30. Epub 2020 May 30.

Department of Surgery, Assistance Publique Hôpitaux de Paris, Paul-Brousse Hospital, Centre Hépato-Biliaire, 94800, Villejuif, France.

Introduction: Curative treatment of perihilar tumors requires major hepatectomy responsible for high morbidity and mortality. Current nomograms are based on definitive pathological analysis, not usable for patient selection. Our aim was to propose preoperative predictors for severe morbidity (Dindo-Clavien ≥3) and mortality at sixth month after resection of perihilar tumors. Read More

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http://dx.doi.org/10.1007/s00268-020-05618-8DOI Listing

Are Routine Postoperative Laboratory Tests Necessary After Primary Total Hip Arthroplasty?

J Arthroplasty 2020 May 7. Epub 2020 May 7.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Recently, the practice of ordering routine postoperative laboratory tests in primary total hip arthroplasty (THA) has been challenged. This study aimed to evaluate the utility of routine postoperative laboratory tests after primary elective THA in an Asian population and identify the risk factors associated with abnormal postoperative laboratory test-related intervention.

Methods: We retrospectively reviewed 395 consecutive patients who underwent primary elective THA at a single tertiary academic center. Read More

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http://dx.doi.org/10.1016/j.arth.2020.04.097DOI Listing
May 2020
2.666 Impact Factor

Cronkhite-Canada syndrome: report of a rare case and review of the literature.

J Int Med Res 2020 May;48(5):300060520922427

Department of Nephrology, Shandong University Qilu Hospital, Jinan, China.

Cronkhite-Canada syndrome is rarely encountered in clinical practice. Notably, most patients with Cronkhite-Canada syndrome exhibit hypoalbuminemia. Because the cause of Cronkhite-Canada syndrome is unknown, no specific treatment method has been established. Read More

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http://dx.doi.org/10.1177/0300060520922427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273782PMC