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    Clinical outcomes, histopathological patterns, and chemical analysis of Ayurveda and herbal medicine associated with severe liver injury-A single-center experience from southern India.
    Indian J Gastroenterol 2018 Feb 24. Epub 2018 Feb 24.
    Department of Gastroenterology, PVS Memorial Hospital, Kochi, 682 025, India.
    Introduction: Ayurvedic and herbal medicines (AHM) are known to cause varying degrees of drug-induced liver injury (DILI). Clinical, biochemical, histological spectrum and outcomes of AHM linked to severe DILI are not well studied.

    Methods: Out of 1440 liver disease patients, 94 were found to have a severe liver injury and associated AHM intake. Read More

    The role of dimethyl sulfoxide (DMSO) in ex-vivo examination of human skin burn injury treatment.
    Spectrochim Acta A Mol Biomol Spectrosc 2018 Feb 13;196:344-352. Epub 2018 Feb 13.
    Faculty of Materials, Civil and Environmental Engineering, University of Bielsko-Biała, Poland.
    Dimethyl sulfoxide (DMSO) is one of the most versatile solvents in biological science, therefore it is frequently used as a solvent in biological studies and as a vehicle for drug therapy. DMSO readily penetrates, diffuses through biological membranes and ipso facto increases fluidity of liposomal membranes modelling stratum corneum. Thermal injury is associated with the appearance of lipid peroxidation products in the burned skin. Read More

    Percutaneous endoscopic gastrostomy site infections-Incidence and risk factors.
    Indian J Gastroenterol 2018 Feb 23. Epub 2018 Feb 23.
    Department of Gastroenterology, Amrita Institute of Medical Sciences, Ponekkara, Kochi, 682 041, India.
    Background: Percutaneous endoscopic gastrostomy (PEG) placement is the modality of choice for long-term enteral nutrition in view of technical ease and cost-effectiveness. Peristomal infection (PI) remains the most common complication following PEG tube placement. The aim of this study was to assess the incidence and risk factors for PI and outline a microbiological profile that can aid in prophylactic and therapeutic strategies. Read More

    The modified glasgow prognostic score is an independent prognostic indicator in neoadjuvantly treated adenocarcinoma of the esophagogastric junction.
    Oncotarget 2018 Jan 8;9(6):6968-6976. Epub 2018 Jan 8.
    Department of Surgery, Medical University of Vienna, and Gastroesophageal Tumor Unit, Comprehensive Cancer Center (CCC), 1090 Vienna, Austria.
    The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. Read More

    Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.
    JCI Insight 2018 Feb 22;3(4). Epub 2018 Feb 22.
    Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Progressive chronic kidney diseases (CKDs) are on the rise worldwide. However, the sequence of events resulting in CKD progression remain poorly understood. Animal models of CKD exploring these issues are confounded by systemic toxicities or surgical interventions to acutely induce kidney injury. Read More

    The small bowel diseases detected by capsule endoscopy in patients with chronic abdominal pain: A retrospective study.
    Medicine (Baltimore) 2018 Feb;97(8):e0025
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
    Chronic abdominal pain (CAP) remains a particular challenge because of its complicated causes, especially when the disorders involve the small bowel, where it is quite difficult to intubate the flexible endoscopes. This study was to investigate the small bowel diseases detected by capsule endoscopy (CE) in CAP patients to evaluate the role of CE on CAP, and analyzed the relationship among the clinical characteristics of CAP patients and the positive rates of CE findings to search for the indications of CE for CAP patients.This retrospective study included 341 patients with CAP defined as recurrent abdominal pain for no <3 months. Read More

    Murine Typhus in South Texas Children: An 18-Year Review.
    Pediatr Infect Dis J 2018 Feb 19. Epub 2018 Feb 19.
    Driscoll Children's Hospital, Corpus Christi, TX.
    Background: Murine typhus is a zoonotic infection caused by Rickettsia typhi that remains endemic in South Texas. In 2003, only 9 Texas counties reported murine typhus compared with 41 counties in 2013.

    Methods: A retrospective study of children discharged with a confirmed diagnosis of murine typhus from Driscoll Children's Hospital between January 1998-September 2016. Read More

    Accelerated Infliximab Dosing Increases 30-Day Colectomy in Hospitalized Ulcerative Colitis Patients: A Propensity Score Analysis.
    Inflamm Bowel Dis 2018 Feb;24(3):651-659
    Department of Medicine and Pediatrics, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Standard outpatient induction dosing of infliximab (IFX) may not be effective in hospitalized ulcerative colitis (UC) patients with higher inflammatory burden and colectomy risk. Our aim was to determine whether initial IFX induction dose affects 30-day colectomy rate and other disease-related outcomes.

    Methods: IFX-naive hospitalized UC patients receiving at least 1 inpatient 5 mg/kg (SD) or 10 mg/kg (HD) IFX induction dose were included. Read More

    Hypoalbuminaemia as a marker of trans-capillary leakage in community-acquired bacteraemia patients.
    Epidemiol Infect 2018 Feb 19:1-8. Epub 2018 Feb 19.
    Department of Emergency Medicine,Odense University Hospital,Kløvervænget 25,entrance 63-65,5000 Odense C,Denmark.
    Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. Read More

    Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes.
    JA Clin Rep 2018 22;4(1). Epub 2018 Jan 22.
    Department of Dental Anesthesiology, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 Japan.
    Background: Secretion of hormones, which antagonize the action of insulin, is facilitated in response to surgery, and acute resistance to the action of insulin develops. Our aim is to elucidate the effects of intraoperative glycemic control by glucose-insulin (GI) infusion on postoperative complications and outcomes in major oral and maxillofacial surgery.

    Findings: Thirty patients aged ≥ 60 years undergoing a radical operation of oral malignant tumors with tissue reconstruction (≥ 8 h) were analyzed. Read More

    Models of disuse muscle atrophy: therapeutic implications in critically ill patients.
    Ann Transl Med 2018 Jan;6(2):29
    Pulmonology Department, Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain.
    Skeletal muscle weakness is common in the intensive care units (ICU). Approximately 50% of patients under mechanical ventilation for more than 7 days show signs of ICU-acquired muscle weakness. In these patients, muscle weakness may be the result of axonal polyneuropathy, myopathy or a combination of both. Read More

    Prognostic value of circulating biomarker score in advanced-stage head and neck squamous cell carcinoma.
    Eur J Cancer 2018 Mar 8;92:69-76. Epub 2018 Feb 8.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Background: Circulating biomarker (CB) is a convenient, emerging predictive tool for treatment response and outcomes in human cancers. Therefore, we examined the prognostic value of pre-treatment and early post-treatment CBs and their summated scores in patients with head and neck squamous cell carcinoma (HNSCC).

    Methods: This study prospectively included 310 consecutive patients who underwent definitive treatment for previously untreated advanced-stage HNSCC between 2010 and 2015. Read More

    Zinc Deficiency-Like Syndrome in Fleckvieh Calves: Clinical and Pathological Findings and Differentiation from Bovine Hereditary Zinc Deficiency.
    J Vet Intern Med 2018 Feb 9. Epub 2018 Feb 9.
    Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich, Oberschleißheim, Germany.
    Background: Zinc deficiency-like (ZDL) syndrome is an inherited defect of Fleckvieh calves, with striking similarity to bovine hereditary zinc deficiency (BHZD). However, the causative mutation in a phospholipase D4 encoding gene (PLD4) shows no connection to zinc metabolism.

    Objectives: To describe clinical signs, laboratory variables, and pathological findings of ZDL syndrome and their utility to differentiate ZDL from BHZD and infectious diseases with similar phenotype. Read More

    Variability in Predialysis Systolic Blood Pressure and Long-Term Outcomes in Hemodialysis Patients.
    Kidney Blood Press Res 2018 Jan 31;43(1):115-124. Epub 2018 Jan 31.
    Background/aims: While systolic blood pressure variability (SBPV) is an independent risk factor for mortality in the general population, its association with outcomes in hemodialysis patients has been less well-investigated.

    Methods: In this retrospective study, we enrolled 99 eligible HD patients from 2006 to 2016. Predialysis blood pressure measurements obtained over 1-year period were used to determine each patient's BPV. Read More

    Pre-operative core muscle index in combination with hypoalbuminemia is associated with poor prognosis in advanced ovarian cancer.
    J Surg Oncol 2018 Feb 6. Epub 2018 Feb 6.
    The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background And Objectives: Age and frailty have been correlated with poor clinical outcomes in cancer. Core muscle index (CMI) and nutritional status are integral in assessing frailty. We explored the effect of pre-operative serum albumin and body composition on clinical outcomes in patients with epithelial ovarian cancer (EOC). Read More

    Incidence and Factors Correlating With Incisional Hernia Following Open Bowel Resection in Patients With Inflammatory Bowel Disease: A Review of 1000 Patients.
    Ann Surg 2018 Mar;267(3):532-536
    The Department of Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY.
    Objective: The aim of this study was to identify the incidence and factors associated with the development of incisional hernia (IH) in patients with inflammatory bowel disease (IBD) undergoing open bowel resections.

    Background: Predisposing factors for IH have not been well studied in patients with IBD undergoing open bowel resection. The role of duration of the disease, nutritional factors, anti-inflammatory treatment, previous operative procedures, wound infection, and other complicating factors remains unclear. Read More

    Malnutrition, Growth Response and Metabolic Changes Within the First 24 Months After ART Initiation in HIV-Infected Children Treated Before the Age of Two Years in West Africa.
    Pediatr Infect Dis J 2018 Feb 3. Epub 2018 Feb 3.
    Inserm U1027, University Paul Sabatier Toulouse 3, Toulouse, France.
    Background: There is limited information about malnutrition, growth evolution and metabolic changes among children initiated early on lopinavir-based antiretroviral therapy (ART) in Africa.

    Methods: HIV-1-infected children, age <2 years were initiated on ART, as part of the MONOD ANRS 12206 project, conducted in Burkina Faso and Côte d'Ivoire. Weight-for-age, height-for-age and weight-for-height Z-scores (WAZ, HAZ, WHZ) defined malnutrition (Z-score <-2 standard deviations [SD]) using WHO growth references. Read More

    Intradialytic Hypotension as an Independent Risk Factor for Long-Term Mortality in Maintaining Hemodialysis Patients: A 5-Year Follow-Up Cohort Study.
    Blood Purif 2018 Feb 2;45(4):320-326. Epub 2018 Feb 2.
    Division of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
    Aims: This study aimed to assess risk factors of intradialytic hypotension (IDH) and the association of prognosis and IDH among maintenance hemodialysis (MHD) patients.

    Methods: Among 293 patients, 117 were identified with IDH (more than 4 hypotensive events during 3 months). The association between IDH and survival was evaluated. Read More

    Inflammation and nutritional status assessment by malnutrition inflammation score and its outcome in pre-dialysis chronic kidney disease patients.
    Clin Nutr 2018 Jan 9. Epub 2018 Jan 9.
    Department of Nephrology, Sri Ramachandra Medical College and Research Institute (Deemed to be University), No 1, Ramachandra Nagar Porur, Chennai, 600 116, India.
    Background: Malnutrition-inflammation complex syndrome (MICS), hyperhomocysteinemia, calcium and phosphate levels derangement have been predicted as important contributing factors for the progression of cardiovascular burden. Among patients with earlier stage of CKD, hypoalbuminaemia and inflammation deliberated as non-traditional cardiovascular risk factors, which add more burden to circulatory disease, mortality and rapid advancement to CKD stage 5.

    Aim: The aim of the study is to evaluate inflammation and nutritional status of CKD patients not on dialysis using Malnutrition inflammation score (MIS) and to verify the association with mortality in the follow-up period. Read More

    Identification of Independent Risk Factors for Complications: A Retrospective Analysis of 163 Fibular Free Flaps for Mandibulofacial Reconstruction.
    J Oral Maxillofac Surg 2018 Jan 8. Epub 2018 Jan 8.
    Department Head, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address:
    Purpose: Fibular free flap transfer is a powerful tool available to the reconstructive surgeon when treating oral and maxillofacial defects, but complications still occasionally occur and predictive analysis focusing on this specific flap is limited in terms of risk factors for complication. The purpose of this study was to identify key variables associated with complications in patients undergoing fibular free flap transfer.

    Patients And Methods: The data of 163 consecutive patients who underwent fibular free flap surgery at the Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, between 2012 and 2015 were reviewed retrospectively. Read More

    Impact of body mass index on clinicopathological outcomes in patients with renal cell carcinoma without anorexia-cachexia syndrome.
    Mol Clin Oncol 2018 Jan 27;8(1):47-53. Epub 2017 Oct 27.
    Department of Urology, National Defense Medical College, Tokorozawa 359-8513, Japan.
    Although obesity defined by a high body mass index (BMI) is generally associated with increased risk of renal cell carcinoma (RCC), low BMI has paradoxically been associated with increased tumor aggressiveness and poor prognosis. As anorexia-cachexia syndrome (ACS) is associated with decreased BMI and is frequently observed in patients with advanced RCC, the present study investigated the association of BMI with tumor aggressiveness and prognosis in RCC in relation to ACS. The association of BMI with clinicopathological parameters was analyzed in 503 consecutive patients who underwent surgery for RCC. Read More

    Thromboelastometric assessment of hemostasis following hydroxyethyl starch (130/0.4) administration as a constant rate infusion in hypoalbuminemic dogs.
    BMC Vet Res 2018 Jan 31;14(1):33. Epub 2018 Jan 31.
    Department of Veterinary Science, University of Turin, Largo Paolo Braccini n°2-5, 10095, Grugliasco, TO, Italy.
    Background: The primary aim was to evaluate by means of thromboelastometry (ROTEM) the effects of hydroxyethyl starch (HES) 130/0.4 administered as a constant rate infusion (CRI) on hemostasis in hypoalbuminemic dogs. The second aim was to use ROTEM analysis to detect whether all hypoalbuminemic dogs of our population were hypercoagulable. Read More

    A model for predicting bacteremia in patients with community-acquired pneumococcal pneumonia: a retrospective observational study.
    BMC Pulm Med 2018 Jan 30;18(1):24. Epub 2018 Jan 30.
    Department of Respiratory Medicine, Ohara Memorial Kurashiki Healthcare Foundation, Kurashiki Central Hospital, 1-1-1 miwa, Kurashiki, Okayama, 710-8602, Japan.
    Background: Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development of bacteremia in patients with community-acquired pneumococcal pneumonia.

    Methods: We retrospectively analyzed data from patients hospitalized with community-acquired pneumococcal pneumonia between April 2007 and August 2015. Read More

    The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic liver disease: a single-center retrospective study.
    J Gastroenterol 2018 Jan 27. Epub 2018 Jan 27.
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aobaku, Sendai, 980-8574, Japan.
    Background: It is poorly understood how an imbalance of plasma-free amino acids (PFAAs) occurs and how the imbalance shows an association with the serum albumin (sAlb) level during the progression of chronic liver disease (CLDs). The aim of this study is to elucidate the profiles of PFAAs and the relationship between sAlb and PFAAs in recent patients with CLDs during the progression.

    Methods: We retrospectively evaluated the 1569 data of PFAAs data obtained from 908 patients with various CLDs (CHC, CHB. Read More

    Eosinophilic Gastrointestinal Disorders Pathology.
    Front Med (Lausanne) 2017 15;4:261. Epub 2018 Jan 15.
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
    Eosinophilic gastrointestinal disorders (EGID) are characterized pathologically by excess eosinophils in mucosal biopsies of one or multiple sites in the gastrointestinal (GI) tract, simultaneously or sequentially. Eosinophilic esophagitis (EoE) is the best characterized EGID, and in most patients it is an abnormal immune-mediated response to food antigens. Current recommendations for diagnosis include signs and symptoms of esophageal dysfunction that do not respond to proton-pump inhibitor therapy, and esophageal biopsies that exhibit at least 15 intraepithelial eosinophils in at least one high power field (HPF). Read More

    Predictors of Severity in Pediatric Scrub Typhus.
    Indian J Pediatr 2018 Jan 24. Epub 2018 Jan 24.
    Department of Pediatrics, Indira Gandhi Medical College and Research Institute (IGMC&RI), Pondicherry, India.
    Objective: To identify the factors that can predict the severity of scrub typhus in children.

    Methods: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. Read More

    Kasai procedure improves nutritional status and decreases transplantation-associated complications.
    Pediatr Surg Int 2018 Jan 24. Epub 2018 Jan 24.
    Department of Pediatric Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
    Background: The aim of this study was to retrospectively investigate whether Kasai Procedure (KP) improves nutritional status and whether KP decreases liver transplantation (LT)-associated complications in children with biliary atresia (BA).

    Methods: From March 1st 2014 to February 28th 2015, 103 patients underwent LT and the other 17 without prior KP died during the waiting period. In 103 patients undergoing LT, 58 patients received KP previously (Group A), and 45 only underwent primary LT (Group B). Read More

    E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma: A phase 1 study.
    Cancer Sci 2018 Jan 24. Epub 2018 Jan 24.
    Department of Clinical Development, Eisai Co Ltd, Tokyo.
    E7777, a recombinant cytotoxic fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2, shares an amino acid sequence with denileukin diftitox but has improved purity and an increased percentage of active protein monomer species. A phase 1 study was conducted to evaluate the tolerability, safety, pharmacokinetics and anti-tumour activity of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma. E7777 (6, 12 and expanded 9 μg/kg/day) was administered to 13 patients via intravenous infusion on 5 consecutive days per 21-day cycle. Read More

    Risk factors for 30-day complications after cancer surgery in geriatric patients: a secondary analysis.
    Acta Anaesthesiol Scand 2018 Jan 22. Epub 2018 Jan 22.
    Department of Anesthesiology and Intensive Care Medicine, Klinikum Barnim GmbH, Werner Forßmann Krankenhaus Eberswalde, Eberswalde, Germany.
    Background: The aim was to analyse the association between severity of complications up to 30 days after surgery and pre-operative nutritional and physical performance parameters.

    Methods: The participants were a subsample of the previously published PERATECS study (ClinicalTrials.gov: NCT01278537) and included 517 onco-geriatric patients aged ≥ 65 years, undergoing thoracoabdominal, gynaecological, or urological surgery. Read More

    Clinical, Biomarker, and Molecular Delineations and Genotype-Phenotype Correlations of Ataxia With Oculomotor Apraxia Type 1.
    JAMA Neurol 2018 Jan 22. Epub 2018 Jan 22.
    Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
    Importance: Ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive cerebellar ataxia due to mutations in the aprataxin gene (APTX) that is characterized by early-onset cerebellar ataxia, oculomotor apraxia, axonal motor neuropathy, and eventual decrease of albumin serum levels.

    Objectives: To improve the clinical, biomarker, and molecular delineation of AOA1 and provide genotype-phenotype correlations.

    Design, Setting, And Participants: This retrospective analysis included the clinical, biological (especially regarding biomarkers of the disease), electrophysiologic, imaging, and molecular data of all patients consecutively diagnosed with AOA1 in a single genetics laboratory from January 1, 2002, through December 31, 2014. Read More

    Hypoalbuminemia is Associated With Significantly Higher Liver Transplant Waitlist Mortality and Lower Probability of Receiving Liver Transplant.
    J Clin Gastroenterol 2018 Jan 19. Epub 2018 Jan 19.
    Division of Gastroenterology and Hepatology, Alameda Health System-Highland Hospital, Oakland, CA.
    Goals: To evaluate the predictive value of hypoalbuminemia on liver transplant (LT) waitlist survival and probability of receiving LT among adults with end-stage liver disease (ESLD).

    Background: Growing evidence reports on the negative prognostic value of hypoalbuminemia among ESLD patients awaiting LT.

    Methods: Using 2003 to 2015 United Network for Organ Sharing data, we retrospectively evaluated the impact of mild-moderate (2. Read More

    Hypoalbuminaemia in antineutrophil cytoplasmic antibody-associated vasculitis: incidence and significance.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, China.
    Objectives: Hypoalbuminaemia has been proved to be a biomarker of poor prognosis in many diseases. The objective of this study was to investigate the significance of hypoalbuminaemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

    Methods: Data of 117 AAV patients were analysed retrospectively. Read More

    Membranous nephropathy associated with pregnancy: an anti-phospholipase A2 receptor antibody-positive case report.
    CEN Case Rep 2018 Jan 18. Epub 2018 Jan 18.
    Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
    Pregnancy and membranous nephropathy (MN) can occur concurrently with nephrotic syndrome. However, the pathophysiology of MN associated with pregnancy remains unclear, including the involvement of anti-M-type phospholipase A2 receptor (PLA2R) antibody, the major antigen of idiopathic MN (iMN). A treatment for the condition is also not established. Read More

    The Effect of Ophiocephalus striatus Extract on the Levels of IGF-1 and Albumin in Elderly Patients with Hypoalbuminemia.
    Acta Med Indones 2017 Oct;49(4):324-329
    Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Sumatera Barat, Indonesia.
    Background: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia.

    Methods: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23. Read More

    Hypoalbuminaemia segregates different prognostic subgroups within the refined standard risk acute graft-versus-host disease score.
    Br J Haematol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, USA.
    Hypoalbuminaemia has been previously described to predict worse non-relapse mortality (NRM) and inferior overall survival (OS) in allogeneic haematopoietic cell transplant (allo-HCT) recipients. Here, we evaluate the role of hypoalbuminaemia (<35 g/l) at time of onset of acute graft-versus-host disease (aGVHD) when incorporated into the refined aGVHD score. The study population consisted of 522 patients, median age 53 (18-75) years, who underwent an allo-HCT mostly for haematological malignancies. Read More

    Capillary leak syndrome as a complication of antibody-mediated rejection treatment: a case report.
    CEN Case Rep 2018 Jan 17. Epub 2018 Jan 17.
    Nephrology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Calle Vasco de Quiroga 15, Tlalpan, Sección XVI, 14000, Mexico City, Mexico.
    We report a case of capillary leak that developed during treatment of antibody-mediated rejection in a kidney transplant recipient. A 53-year-old female transplant recipient experienced an increase in serum creatinine from 1.1 to 1. Read More

    [X-linked inhibitor of apoptosis deficiency manifested as Crohn's disease: a case report and literature review].
    Zhonghua Er Ke Za Zhi 2018 Jan;56(1):43-47
    Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
    To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease.Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed. Read More

    Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease.
    Nutrients 2018 Jan 14;10(1). Epub 2018 Jan 14.
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0123, Japan.
    Zinc (Zn) is an essential trace element which has favorable antioxidant, anti-inflammatory, and apoptotic effects. The liver mainly plays a crucial role in maintaining systemic Zn homeostasis. Therefore, the occurrence of chronic liver diseases, such as chronic hepatitis, liver cirrhosis, or fatty liver, results in the impairment of Zn metabolism, and subsequently Zn deficiency. Read More

    [Factors Predicting the Interface Pressure Related to Pressure Injury in Intensive Care Unit Patients].
    J Korean Acad Nurs 2017 Dec;47(6):794-805
    College of Nursing · Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
    Purpose: Interface pressure is a factor that contributes to the occurrence of pressure injuries. This study aimed to investigate interface pressure at common sites of pressure injury (occipital, gluteal and peritrochanteric areas), to explore the relationships among risk factors, skin condition and interface pressure, and to identify risk factors influencing interface pressure.

    Methods: A total of 100 patients admitted to the intensive care unit were enrolled at a tertiary teaching hospital in Korea. Read More

    Hyposalivation and 10-year all-cause mortality in an elderly Japanese population.
    Gerodontology 2018 Jan 10. Epub 2018 Jan 10.
    Division of Preventive Dentistry, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
    Objective: To evaluate the association of salivary flow rate with all-cause mortality among older Japanese adults. We hypothesised that hyposalivation would be a marker for mortality.

    Background: Hyposalivation, which is an objectively measurable decrease in salivary flow, is highly prevalent among older adults. Read More

    Is the Glasgow Prognostic Score Applicable to Both Early- and Advanced-Stage Gastric Cancers?
    Gastroenterology Res 2017 Dec 3;10(6):359-365. Epub 2018 Jan 3.
    Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
    Background: The Glasgow prognostic score (GPS) has been reported as a sensitive prognostic marker for gastric cancer. This study aimed to investigate whether the GPS is equally applicable to patients with early-stage and advanced-stage gastric cancers.

    Methods: Patients (n = 544) who underwent elective gastrectomy for gastric cancer between 2007 and 2015 were retrospectively studied. Read More

    Risk factors and prognosis value of venous thromboembolism in patients with advanced non-small cell lung cancer: a case-control study.
    J Thorac Dis 2017 Dec;9(12):5068-5074
    Department of Respiratory Disease, First Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, China.
    Background: Venous thromboembolism (VTE) is the well-known complication of cancer, especially among lung cancer patients. The objective of this study is to identify the incidence, risk factors and prognosis of VTE in the patients with non-small cell lung cancer (NSCLC) in an advanced or metastatic stage (stage III or IV). We hypothesized that NSCLC patients associated with VTE may lead to poor prognosis. Read More

    Anemia, hypoalbuminemia, and elevated troponin levels as risk factors for respiratory failure in patients with severe exacerbations of chronic obstructive pulmonary disease requiring invasive mechanical ventilation.
    Croat Med J 2017 Dec;58(6):395-405
    Marina Labor, Department of Pulmonology, University Hospital Center Osijek, Faculty of Medicine, J.J. Strossmayer University of Osijek, 31000 Osijek, Croatia,
    Aim: To determine in-hospital and post-discharge mortality, readmission rates, and predictors of invasive mechanical ventilation (IMV) in patients treated at intensive care unit (ICU) due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

    Methods: A retrospective observational cohort study included all patients treated at a respiratory ICU for AECOPD during one year. A total of 62 patients (41 men) with mean age 68. Read More

    Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL.
    Blood Adv 2017 Dec 11;1(26):2600-2609. Epub 2017 Dec 11.
    Division of Hematology/Oncology, Tufts Medical Center, Boston, MA.
    Gray zone lymphoma (GZL) is described as sharing features with classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). However, there remains complexity in establishing diagnosis, delineating prognosis, and determining optimum therapy. Sixty-eight cases diagnosed as GZL across 15 North American academic centers were evaluated by central pathology review to achieve consensus. Read More

    Clinical Presentation, Prognostic Factors, and Outcome in Neutropenic Enteropathy of Childhood Leukemia.
    J Pediatr Hematol Oncol 2017 Dec 29. Epub 2017 Dec 29.
    Departments of Pediatric Surgery.
    Leukemia patients are at risk for neutropenic enteropathy (NEP) because of the effects of intensified chemotherapy. Medical records of 18 patients having 20 episodes of NEP were reviewed retrospectively. Primary diagnosis was acute lymphoblastic leukemia in 12 and myeloblastic leukemia in 6 cases. Read More

    Predictive modeling of inpatient mortality in departments of internal medicine.
    Intern Emerg Med 2017 Dec 30. Epub 2017 Dec 30.
    Department of Medicine D, Emek Medical Center, Clalit Health Services, 21 Rabin Avenue, 18341, Afula, Israel.
    Despite overwhelming data on predictors of inpatient mortality, it is unclear which variables are the most instructive in predicting mortality of patients in departments of internal medicine. This study aims to identify the most informative predictors of inpatient mortality, and builds a prediction model on an individual level, given a constellation of patient characteristics. We use a penalized method for developing the prediction model by applying the least-absolute-shrinkage and selection-operator regression. Read More

    Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria.
    J Pediatr Surg 2017 Dec 6. Epub 2017 Dec 6.
    Division Of Pediatrics Infectious Disease University of Nebraska Medical Center, Omaha, USA.
    Background: Intestinal perforation is a serious but poorly understood complication of typhoid fever. This study aims to determine the patient factors associated with postoperative morbidity and mortality.

    Methods: We retrospectively reviewed the records of all children presenting to our unit with typhoid intestinal perforation (TIP) between March 2009 and December 2013. Read More

    α-asarone reduce proteinuria by restoring antioxidant enzymes activities and regulating necrosis factor κB signaling pathway in doxorubicin-induced nephrotic syndrome.
    Biomed Pharmacother 2018 Feb 27;98:318-324. Epub 2017 Dec 27.
    Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai, 400068, Maharashtra, India. Electronic address:
    α-asarone is natural bioactive compound that has been reported to have many benefits and medicinal properties. The present study aimed to assess the protective effect of α-asarone against doxorubicin (DOX) induced nephrotic syndrome in rats. An experimental nephrotic syndrome was induced by single intravenous injection of DOX (7 mg/kg) in rats. Read More

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