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    Pseudoesterase activity of albumin: A probable determinant of cholesterol biosynthesis.
    Med Hypotheses 2018 Jun 30;115:42-45. Epub 2018 Mar 30.
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:
    The association between hypoalbuminemia and coronary artery disease is known from some time. However, the reason as to how such phenomenon is correlated remains unknown. We have observed from published scientific literature that HSA has the potential to control cholesterol biosynthesis due to its pseudoesterase activity. Read More

    Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice.
    Hepatol Res 2018 Apr 22. Epub 2018 Apr 22.
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
    Aim: As second-line therapy, regorafenib has been shown to provide a survival benefit for patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this retrospective study, we assessed the clinical outcomes of sorafenib treatment failure with regard to second-line chemotherapy.

    Methods: Patients (N=160) with advanced HCC, Child-Pugh A liver function and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 treated with sorafenib between June 2009 and September 2016 were enrolled. Read More

    [Risk factors of anastomotic leakage after anterior resection for rectal cancer and the diagnostic value of computed tomography signs in anastomotic leakage].
    Zhonghua Wei Chang Wai Ke Za Zhi 2018 Apirl 25;21(4):419-424
    Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
    Objective: To investigate the risk factors and computed tomography (CT) diagnostic accuracy of anastomotic leakage after resection of rectal cancer (Dixon).

    Methods: This retrospective study was conducted in Peking University First Hospital from January 2013 to June 2015. A cohort of 452 patients with rectal cancer was enrolled in the study. Read More

    Hydroelectrolytic and infectious complications in one year of parenteral nutrition in critical care.
    Rev Esp Anestesiol Reanim 2018 Apr 18. Epub 2018 Apr 18.
    Grupo de Investigación en Anestesia y Cuidados Críticos, Instituto de Investigación Sanitaria Galicia SUR (ISS Galicia Sur). SERGAS-UVigo, Vigo, España; Servicio de Anestesia y Reanimación, Complexo Hospitalario Universitario de Ourense (CHUO), Sergas, Ourense, España.
    Objective: Parenteral nutrition consists of the intravenous administration of macronutrients, micronutrients and electrolytes. Our objectives were to evaluate the biochemical alterations during the first ten days of initiation and to quantify the bacteremia related to the central venous catheter during the administration of parenteral nutrition.

    Material And Methods: Retrospective study of incidence and prevalence. Read More

    Human serum albumin in cardiovascular diseases.
    Eur J Intern Med 2018 Apr 18. Epub 2018 Apr 18.
    Service de Cardiologie, Centre hospitalier Edmond Garcin, Aubagne, France. Electronic address:
    Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Read More

    D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
    Case Rep Hematol 2018 18;2018:3890361. Epub 2018 Feb 18.
    Serviço de Hematologia Clínica, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.
    Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML).

    Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. Read More

    Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
    Pediatr Nephrol 2018 Apr 16. Epub 2018 Apr 16.
    Dr. v. Hauner Children's Hospital, Division of Pediatric Nephrology, Ludwig-Maximilians University, Lindwurmstraße 4, 80337, Munich, Germany.
    Background: Congenital nephrotic syndrome (CNS) is primarily a monogenetic disease, with the majority of cases due to changes in five different genes: the nephrin (NPHS1), podocin (NPHS2), Wilms tumor 1 (WT1), laminin ß2 (LAMB2), and phospholipase C epsilon 1 (PLCE1, NPHS3) gene. Usually CNS is not responsive to immunosuppressive therapy, but treatment with ACE inhibitors, AT1 receptor blockade and/or indomethacin can reduce proteinuria. If the disease progresses to end-stage renal disease, kidney transplantation is the therapy of choice. Read More

    Nutritional Insufficiency as a Predictor for Adverse Outcomes in Adult Spinal Deformity Surgery.
    Global Spine J 2018 Apr 30;8(2):164-171. Epub 2017 Jun 30.
    Icahn School of Medicine at Mount Sinai, New York NY, USA.
    Study Design: Retrospective analysis of prospectively collected data.

    Objective: The effect of malnutrition on outcomes after general surgery has been well reported in the literature. However, there is a paucity of data on the effect of malnutrition on postoperative complications during adult deformity surgery. Read More

    Missing data treatments matter: an analysis of multiple imputation for anterior cervical discectomy and fusion procedures.
    Spine J 2018 Apr 9. Epub 2018 Apr 9.
    Department of Orthopaedics and Rehabilitation, Yale School of Medicine, 800 Howard Avenue, New Haven, CT 06510. Electronic address:
    Background Context: The presence of missing data is a limitation of large datasets, including the National Surgical Quality Improvement Program (NSQIP). In addressing this issue, most studies utilize complete case analysis, which excludes cases with missing data, thus potentially introducing selection bias. Multiple imputation, a statistically rigorous approach that approximates missing data and preserves sample size, may be an improvement over complete case analysis. Read More

    A Rare Case of Calciphylaxis in an Orthotopic Liver Transplant Recipient with Acute Kidney Injury.
    Exp Clin Transplant 2018 Apr 9. Epub 2018 Apr 9.
    From the Department of Transplant Nephrology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.
    Calciphylaxis is a rare disease characterized by calcification of small- to medium-sized blood vessels in the dermis and subcutaneous fat, resulting in cutaneous necrosis. Although most commonly shown in patients with end-stage kidney disease, it has also been reported in patients with other diseases, including alcoholic cirrhosis and malignancies. Here, we report an unusual case of calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury. Read More

    Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves.
    J Vet Med Sci 2018 Apr 6. Epub 2018 Apr 6.
    Department of Veterinary Medicine and Surgery, University of Missouri, College of Veterinary Medicine.
    Five Japanese Black embryo transfer calves from a single embryo flush, 30 to 45-days-old, including 4 live animals for clinical examination and 1 dead for necropsy, were presented with a history of decreased milk intake and hypoproteinemia. Consistent clinicopathological abnormalities in the 4 calves presented for clinical evaluation included hyperkalemia, hyperphosphatemia, hypoproteinemia, hypoalbuminemia, hyperbilirubinemia, increased creatine phosphokinase activity, and proteinuria. Four calves ultimately were necropsied and all had histologic evidence of immune complex glomerulonephritis. Read More

    Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure.
    Egypt Heart J 2017 Sep 7;69(3):201-208. Epub 2017 Mar 7.
    Anasethia and Intensive Care Department, Suez Canal University, Egypt.
    Objective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF).

    Subjects And Methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Read More

    Severe Cognitive Impairment Associated With a High Free But Therapeutic Total Concentration of Valproic Acid Due to Hypoalbuminemia in an Older Patient With Bipolar Disorder.
    J Clin Psychopharmacol 2018 Jun;38(3):265-268
    Altrecht Institute for Mental Health Care Old Age Psychiatry Utrecht, The Netherlands Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht and Brocacef Ziekenhuisfarmacie Maarssen, The Department of Psychiatry GGZ inGeest/VU University Medical Center Amsterdam, The Netherlands Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University and Department of Clinical Pharmacy University Medical Center Utrecht Utrecht, The Netherlands Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Research Group Innovation of Pharmaceutical Care University of Applied Sciences Utrecht and Department of Clinical Pharmacy University Medical Center Utrecht Utrecht, The Netherlands.

    Pharmacokinetic/Pharmacodynamic Considerations of Beta-Lactam Antibiotics in Adult Critically Ill Patients.
    Curr Infect Dis Rep 2018 Apr 4;20(5). Epub 2018 Apr 4.
    Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
    Purpose Of Review: Beta-lactam antibiotics are commonly prescribed in critically ill patients for a variety of infectious conditions. Our understanding of how critical illness alters beta-lactam pharmacokinetics/pharmacodynamics (PK/PD) is rapidly evolving.

    Recent Findings: There is a growing body of literature in adult patients demonstrating that physiological alterations occurring in critically ill patients may limit our ability to optimally dose beta-lactam antibiotics to reach these PK/PD targets. Read More

    [Idiopathic systemic capillary leak syndrome (Clarkson disease) : A rare cause of recurrent life-threatening edema].
    Internist (Berl) 2018 Apr 4. Epub 2018 Apr 4.
    Helios Universitätsklinikum Wuppertal, Wuppertal, Deutschland.
    This case report describes the episodic occurrence of severe generalized edema in a young female patient, who developed hypertension with a massive hemoconcentration (hematocrit >0.5, hemoglobin >20g/dl) and hypoalbuminemia during the course of these acute disease phases. After the first two disease exacerbations were overcome, there was a complete regression of symptoms. Read More

    Celiac Disease and Secondary Amyloidosis: A Possible Causal Association?
    ACG Case Rep J 2018 28;5:e24. Epub 2018 Mar 28.
    Department of Pathology, Govind Ballabh Pant Hospital, New Delhi, Delhi, India.
    We report a rare case of secondary renal amyloidosis in a patient with probable celiac disease presenting as nephrotic syndrome. A 30-year-old man with chronic diarrhea presented with progressive anasarca for 2 years. On further evaluation, he had hypoalbuminemia, significant nephrotic-range proteinuria, and elevated levels of anti-tissue transglutaminase. Read More

    [Clinical features and genetic variants of Dent disease in 10 children].
    Zhonghua Er Ke Za Zhi 2018 Apr;56(4):289-293
    Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
    To summarize the clinical features and genetic analysis results of 10 children with Dent disease. The clinical data and gene test results of 10 boys aged from 8 months to 12 years with Dent disease diagnosed in Children's Hospital of Nanjing Medical University from January 2014 to July 2017 were analyzed retrospectively. All patients had insidious onset, 5 cases were found to have proteinuria on routine urine examination after hospitalization duo to other diseases, 4 cases were admitted to hospital because increased foams in the urine, and 1 case was found to have proteinuria on health checkup. Read More

    Risk Factors for Thirty-Day Morbidity and Mortality in Extradural Lumbar Spine Tumor Resection.
    World Neurosurg 2018 Mar 31. Epub 2018 Mar 31.
    Department of Neurosurgery, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    Background: Epidural tumors in the lumbar spine represent a unique cohort of lesions with individual risks and challenges to resection. Knowledge of modifiable risk factors are important in minimizing postoperative complications.

    Objective: To determine the risk factors for 30-day morbidity and mortality in patients undergoing extradural lumbar tumor resection. Read More

    Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency.
    Gastroenterology 2018 Mar 28. Epub 2018 Mar 28.
    Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; St. Anna Kinderspital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria. Electronic address:
    Background & Aims: Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from diacylglycerol and acyl-CoA. We investigated the mechanisms by which DGAT1 deficiency contributes to intestinal failure using patient-derived organoids.

    Methods: We collected blood samples from 10 patients, from 6 unrelated pedigrees, who presented with early-onset severe diarrhea and/or vomiting, hypoalbuminemia, and/or (fatal) protein-losing enteropathy with intestinal failure; we performed next-generation sequence analysis of DNA from 8 patients. Read More

    Serum albumin concentration as an independent prognostic indicator in patients with pulmonary arterial hypertension.
    Clin Cardiol 2018 Mar 31. Epub 2018 Mar 31.
    Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Introduction: Serum albumin is a strong prognostic indicator for many disease processes, yet limited data exist regarding its prognostic relationship in pulmonary arterial hypertension (PAH). Our study aims to assess the relationship of hypoalbuminemia with disease severity and mortality in this population.

    Methods: A retrospective review of all patients with WHO group 1 PAH evaluated between March 2001 and August 2008 was performed. Read More

    The relationship of delirium and risk factors in cardiology intensive care unit patients with the nursing workload.
    J Clin Nurs 2018 Mar 31. Epub 2018 Mar 31.
    Ankara University Faculty of Health Sciences, Ankara, Turkey.
    Aims And Objectives: The aim of the study is to evaluate the relationship of delirium and risk factors in cardiology intensive care unit (ICU) patients with the nursing workload.

    Background: Delirium is a common syndrome in patients with cardiac problems. The risk factors causing delirium and the presence and type of delirium affect the nurse workload and patient care quality adversely. Read More

    Investigation and simulation of dissolution with concurrent degradation under healthy and hypoalbuminaemic simulated parenteral conditions- case example Amphotericin B.
    Eur J Pharm Biopharm 2018 Mar 27. Epub 2018 Mar 27.
    Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom. Electronic address:
    Guidance on dissolution testing for parenteral formulations is limited and not often related in vivo performance. Critically ill patients represent a target cohort, frequently hypoalbuminaemic, to whom certain parenteral formulations are administered. Amphotericin B (AmB) is a poorly soluble, highly protein-bound drug, available as lipid-based formulations and used in critical illness. Read More

    Evaluation of risk factors for complications after bariatric surgery.
    J Visc Surg 2018 Mar 26. Epub 2018 Mar 26.
    Unité multidisciplinaire de la chirurgie de l'obésité (UMCO), hôpital de Brabois, université de Lorraine, CHU de Nancy, 11, allée du Morvan, 54511 Vandoeuvre-les-Nancy, France; Unité Inserm U954, faculté de médecine, université de Lorraine, CHU de Nancy, 11, allée du Morvan, 54511 Vandoeuvre-les-Nancy, France. Electronic address:
    The decision to perform a bariatric surgical procedure, the conclusion of a clinical pathway in which management is individually adapted to each patient, is taken after multidisciplinary consultation. Paradoxically, the patients who would most benefit from surgery are also those who have the highest operative risk. In practice, predictive factors of mortality and severe postoperative complications (Clavien-Dindo>III) must be used to evaluate the benefit/risk ratio most objectively. Read More

    Monogenic Causes of Proteinuria in Children.
    Front Med (Lausanne) 2018 12;5:55. Epub 2018 Mar 12.
    Department of Pediatrics, Division of Nephrology, University of California San Francisco, San Francisco, CA, United States.
    Glomerular disease is a common cause for proteinuria and chronic kidney disease leading to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic syndrome in children is diagnosed by the presence of a triad of proteinuria, hypoalbuminemia, and edema. Minimal change disease is the most common histopathological finding in children and adolescents with nephrotic syndrome. Read More

    Nephrotic syndrome in adults.
    Acute Med 2018 ;17(1):36-43
    MD FRCP, Renal Unit, Royal London Hospital, Barts Health NHS Trust London, UK.
    Nephrotic syndrome is an important presentation of glomerular disease characterised by heavy proteinuria, hypoalbuminaemia and oedema. The differential diagnosis of the underlying condition is wide including primary renal disorders and secondary diseases such as malignancy, infection, diabetes and amyloid. Presentations to acute medicine may be with hypervolaemia, complications of the nephrotic state (such as venous thromboembolism), or complications of therapy (such as infection). Read More

    Effects of Serum Albumin, Calcium Levels, Cancer Stage and Performance Status on Weight Loss in Parathyroid Hormone-Related Peptide Positive or Negative Patients with Cancer.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):97-104
    Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: A recent animal study showed that parathyroid hormone-related peptide (PTHrP) is associated with cancer cachexia by promoting adipose tissue browning, and we previously demonstrated that PTHrP predicts weight loss (WL) in patients with cancer. In this study, we investigated whether prediction of WL by PTHrP is influenced by clinical factors such as serum albumin, corrected calcium levels, cancer stage, and performance status (PS).

    Methods: A cohort of 219 patients with cancer whose PTHrP level was measured was enrolled and followed for body weight (BW) changes. Read More

    The Prevalence and Implication of Zinc Deficiency in Patients With Chronic Liver Disease.
    J Clin Med Res 2018 May 16;10(5):437-444. Epub 2018 Mar 16.
    Department of Nutritional Science, Morioka University, 808 Sunakomi, Takizawa 020-0694, Japan.
    Background: Patients with liver cirrhosis often exhibit zinc deficiency. Although zinc is involved in many bioactivities, many aspects of clinical implications of zinc deficiency in liver cirrhosis remain unclear. We aimed to reveal the prevalence and implications of zinc deficiency in liver cirrhosis by assessing associations with parameters such as clinical symptoms and laboratory data. Read More

    Clinical impact of albumin in advanced head and neck cancer patients with free flap reconstruction-a retrospective study.
    PeerJ 2018 12;6:e4490. Epub 2018 Mar 12.
    Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Background: Poor nutritional status among patients with advanced stage head and neck squamous cell carcinoma (HNSCC) is common. Albumin is a common indicator of nutritional status and has been shown to be a predictor of oncological outcomes and perioperative morbidity. This study aims to determine the prognostic value of the serum albumin level among patients with advanced HNSCC undergoing surgery with simultaneous free flap reconstruction. Read More

    Acute cardiac events in severe community-acquired pneumonia: A multicenter study.
    Clin Respir J 2018 Mar 23. Epub 2018 Mar 23.
    Department of Respiratory Diseases, Akdeniz University, School of Medicine, Antalya, Turkey.
    Introduction: An increased risk of cardiovascular complications has been defined in community-acquired pneumonia (CAP), but limited data is available for patients with severe CAP.

    Objective: The aim of the present study was to define the prevalence, characteristics, risk factors and impact on mortality of acute cardiac events in patients with severe CAP during short and long term.

    Method: This investigation was a multicenter, retrospective cohort sudy of patients with severe CAP. Read More

    A Rare Complıcatıon of Gıardıasıs in Chıldren: Proteın Losıng Enteropathy.
    Pediatr Infect Dis J 2018 Mar 19. Epub 2018 Mar 19.
    Div. of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine.
    Protein-losing enteropathy (PLE) may develop as a complication of a wide spectrum of diseases. Three cases of giardiasis that presented with acute onset of hypoalbuminemia were documented, and resolution of protein loss after treatment was also confirmed. Thus, chronic enteric infections should be considered as an etiology of severe intestinal protein loss, particularly in children. Read More

    Proteinuria, Hypoalbuminemia, and Chronic Lymphocytic Leukemia: An Unusual Trio.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618764207. Epub 2018 Mar 14.
    University of California, Davis, Sacramento, CA, USA.
    Chronic lymphocytic leukemia (CLL) is a chronic, progressive lymphoproliferative disorder characterized by a monoclonal population of functionally incompetent lymphocytes. Renal involvement is rare and poorly described. A 57-year-old male with no prior medical history was diagnosed with CLL and followed with a watch and wait approach. Read More

    Conversion of standard Roux-en-Y gastric bypass to distal bypass for weight loss failure and metabolic syndrome: 3-year follow-up and evolution of technique to reduce nutritional complications.
    Surg Obes Relat Dis 2018 Jan 31. Epub 2018 Jan 31.
    Bon Secours St. Mary's Hospital, Richmond, Virginia.
    Background: Standard proximal Roux-en-Y gastric bypass (RYGB) fails to achieve long-term weight maintenance and/or control of metabolic syndrome in up to 35% of patients.

    Objectives: To improve the performance of the standard proximal gastric bypass by increasing the biliopancreatic limb length at the expense of the common channel.

    Settings: Academic-affiliated private practice. Read More

    Discrimination of Kawasaki disease with concomitant adenoviral detection differentiating from isolated adenoviral infection.
    Korean J Pediatr 2018 Feb 28;61(2):43-48. Epub 2018 Feb 28.
    Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea.
    Purpose: Human adenovirus infection mimics Kawasaki disease (KD) but can be detected in KD patients. The aim of this study was to determine the clinical differences between KD with adenovirus infection and only adenoviral infection and to identify biomarkers for prediction of adenovirus-positive KD from isolated adenoviral infection.

    Methods: A total of 147 patients with isolated adenovirus were identified by quantitative polymerase chain reaction. Read More

    Clinical impact of episodic nocturnal hypercapnia and its treatment with noninvasive positive pressure ventilation in patients with stable advanced COPD.
    Int J Chron Obstruct Pulmon Dis 2018 6;13:843-853. Epub 2018 Mar 6.
    Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
    Purpose: Episodic nocturnal hypercapnia (eNH) caused by rapid eye movement (REM) sleep-related hypoventilation is often noted in patients with advanced COPD. The purpose of this study was to clarify the clinical significance of eNH and the effectiveness of eNH-targeted noninvasive positive pressure ventilation (NPPV).

    Patients And Methods: We enrolled patients with stable, severe, or very severe COPD with daytime arterial partial oxygen pressure PaO ≥55 mmHg and daytime arterial partial carbon dioxide pressure PaCO <55 mmHg, who underwent overnight transcutaneous carbon dioxide pressure (PtcCO) monitoring from April 2013 to April 2016. Read More

    Increasing Severity of Malnutrition Is Associated With Poorer 30-Day Outcomes in Patients Undergoing Hip Fracture Surgery.
    J Orthop Trauma 2018 Apr;32(4):155-160
    Department of Orthopedics, University of Mississippi, Jackson, MS.
    Objectives: Low serum albumin levels (hypoalbuminemia) have classically been used to identify malnutrition. The effect of increasing severity of malnutrition on postoperative outcomes in patients undergoing hip fracture surgery has not been well delineated on a large scale.

    Design: Retrospective. Read More

    Azotemia and Proteinuria in Dogs Infected with Babesia gibsoni.
    J Am Anim Hosp Assoc 2018 May/Jun;54(3):156-160. Epub 2018 Mar 20.
    T. Ullal's present affiliation is the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
    Babesiosis is a hemoprotozoal tick-borne disease that is commonly associated with thrombocytopenia and anemia; however, renal involvement has been documented in dogs. The purpose of this retrospective study was to document azotemia and proteinuria in dogs infected with Babesia sp. and to describe the response to antiprotozoal therapy. Read More

    [Goldboom's syndrome: prolonged febrile syndrome with dysproteinemia. Case report].
    Arch Argent Pediatr 2018 Apr;116(2):e331-e335
    Área ambulatoria, Servicio de Mediano Riesgo, Hospital de Pediatría J. P. Garrahan.
    Goldbloom syndrome is a rare clinical entity, of unknown etiology that happens almost exclusively in pediatric population. It is a prolonged febrile syndrome with periosteal hyperostosis and dysproteinemia, and often simulates an hematooncology or lymphoproliferative disease. The diagnosis is to rule out the different causes of bone pain associated with hypergammaglobulinemia, hypoalbuminemia, high erythrocyte sedimentation rate and periostitis at the radiographies. Read More

    Renal dialysis and long-term treatment of a dog with kidney disease associated with canine leishmaniosis.
    Parasit Vectors 2018 Mar 20;11(1):151. Epub 2018 Mar 20.
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
    Background: Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal amyloidosis. Proteinuria is a frequent finding in canine leishmaniosis and its quantification by the urine protein-creatinine ratio (UPC) is an important parameter in the staging of canine lesihmaniosis as presented by the LeishVet group. Read More

    First report of Leishmania infantum infection in the endangered orangutan (Pongo pygmaeus pygmaeus) in Madrid, Spain.
    Parasit Vectors 2018 Mar 20;11(1):185. Epub 2018 Mar 20.
    Zoo de Madrid, Casa de Campo s/n, 28011, Madrid, Spain.
    Background: Some wild animals have been recognized as potential reservoirs of Leishmania infantum infection (e.g. carnivores, lagomorphs, rodents, etc. Read More

    New insights into the clinical characteristics and prognostic factors of pulmonary fungal infections from a retrospective study in Southwestern China.
    Infect Drug Resist 2018 5;11:307-315. Epub 2018 Mar 5.
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
    Background: Despite increasing incidence of pulmonary fungal infections (PFIs) worldwide, the clinical characteristics and prognostic factors remain poorly understood. The goal of this study was to investigate the clinical features, laboratory findings, and outcomes of hospitalized patients diagnosed with PFIs.

    Methods: We retrospectively enrolled 123 patients at a university hospital in Southwestern China between February 2014 and May 2016, who were diagnosed with PFIs based on clinical presentations and laboratory tests including fungal culture and pathological examination. Read More

    Effect of Malnutrition on Radical Nephroureterectomy Morbidity and Mortality: Opportunity for Preoperative Optimization.
    Clin Genitourin Cancer 2018 Feb 23. Epub 2018 Feb 23.
    Department of Urology, NYU Langone Hospital-Brooklyn, Brooklyn, NY. Electronic address:
    Introduction: Nutritional status has been increasingly recognized as an important predictor of prognosis and surgical outcomes for cancer patients. We evaluated the effect of preoperative malnutrition on the development of surgical complications and mortality after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).

    Materials And Methods: Using data from the American College of Surgeons National Surgical Quality Improvement Program, we evaluated the association of poor nutritional status with 30-day postoperative complications and overall mortality after RNU from 2005 to 2015. Read More

    Duration of exposure to multiple antibiotics is associated with increased risk of VRE bacteraemia: a nested case-control study.
    J Antimicrob Chemother 2018 Mar 13. Epub 2018 Mar 13.
    Department of Medicine, University of Cambridge, Cambridge, UK.
    Background: VRE bacteraemia has a high mortality and continues to defy control. Antibiotic risk factors for VRE bacteraemia have not been adequately defined. We aimed to determine the risk factors for VRE bacteraemia focusing on duration of antibiotic exposure. Read More

    [Serum albumin and cardiovascular diseases: A comprehensive review of the literature].
    Ann Cardiol Angeiol (Paris) 2018 Apr 12;67(2):82-90. Epub 2018 Mar 12.
    Service de cardiologie, centre hospitalier Edmond-Garcin, avenue des Soeurs-Gastine, 13400 Aubagne, France. Electronic address:
    Cardiovascular diseases are the leading cause of death worldwide. Conceptually, endothelial dysfunction, inflammatory status and oxidative stress are at the forefront in the onset and development of most cardiovascular diseases, particularly coronary artery disease and heart failure. Serum albumin, the most abundant plasma protein, has many physiological properties, including anti-inflammatory, antioxidant and antiplatelet aggregation activity. Read More

    Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding.
    Oncol Lett 2018 Apr 19;15(4):4193-4200. Epub 2018 Jan 19.
    Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
    The Glasgow Prognostic Score (GPS) has been shown to be associated with survival rates in patients with advanced cancer. The present study aimed to compare the GPS with the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in patients with gastric cancer with peritoneal seeding. For the investigation, a total of 384 gastric patients with peritoneal metastasis were retrospectively analyzed. Read More

    Correlation of clinical, diagnostic and histopathological parameters in dogs with chronic lymphocytic-plasmacytic enteropathy.
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Feb 21;46(1):15-20. Epub 2018 Feb 21.
    Objective: The objective of this study was to correlate clinical signs and diagnostic parameters with duodenal inflammatory and architectural changes in dogs with lymphocytic-plasmacytic enteropathy.

    Material And Methods: In a retrospective study dogs presented between 2003 and 2014 with chronic gastrointestinal signs (duration > 3 weeks) and histologic evidence of intestinal lymphocytic-plasmacytic inflammation were evaluated. Clinical signs, serum albumin, cobalamin and folic acid concentrations were recorded and a sonographic, endoscopic, histologic and cytological inflammatory score was determined. Read More

    Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance.
    Hepatology 2018 Mar 13. Epub 2018 Mar 13.
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR.
    The significance of hepatitis B e-antigen seroclearance (ESC) in the long term is not well defined. The current study aimed to determine the clinical outcomes, the factors and predictive scores for hepatocellular carcinoma (HCC) and hepatitis B surface antigen (HBsAg) seroclearance of a large cohort of patients undergoing ESC. Patients with documented ESC were followed up 3-6 monthly. Read More

    Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome.
    Nephrol Dial Transplant 2018 Mar 9. Epub 2018 Mar 9.
    Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
    Background: Nephrotic syndrome (NS), a chronic kidney disease, is characterized by significant loss of protein in the urine causing hypoalbuminemia and edema. In general, ∼15% of childhood-onset cases do not respond to steroid therapy and are classified as steroid-resistant NS (SRNS). In ∼30% of cases with SRNS, a causative mutation can be detected in one of 44 monogenic SRNS genes. Read More

    Identification of matrix metalloproteinase-2 and -9 activities within the intestinal mucosa of dogs with chronic enteropathies.
    Acta Vet Scand 2018 Mar 12;60(1):16. Epub 2018 Mar 12.
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, (Viikintie 49), 00014, Helsinki, Finland.
    Background: Matrix metalloproteinases (MMPs) 2 and 9 are zinc- and calcium-dependent endopeptidases involved in the breakdown and reconstitution of extracellular matrix under both physiological and pathological conditions. Mucosal MMP-2 and -9 activities have been reported to be upregulated in the intestine of humans with inflammatory bowel disease (IBD), and in animal models of IBD. However, their involvement in the pathogenesis of canine chronic enteropathies (CE) is unknown. Read More

    Improvement of Proteinuria due to Combination Therapy with Daclatasvir and Asunaprevir in Hepatitis C Virus-associated Renal Disease without Cryoglobulinemia: A Case Report.
    Intern Med 2018 Mar 9. Epub 2018 Mar 9.
    Department of Gastroenterology and Hepatology, Kusunoki Hospital, Japan.
    We herein report a unique case of hepatitis C virus (HCV)-associated renal disease without cryoglobulinemia that showed proteinuria, hypoproteinemia, ascites, and edema. Due to combination therapy with daclatasvir and asunaprevir, the patient achieved sustained virological response at week 24 of the therapy. Furthermore, the therapy caused marked amelioration of her proteinuria, ascites, edema, and hypoalbuminemia, and finally improved her estimated glomerular filtration rate. Read More

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