5,693 results match your criteria Hypoalbuminemia


Risk Factors and Treatment Options for Failure of a Two-Stage Exchange.

Curr Rev Musculoskelet Med 2018 Jun 22. Epub 2018 Jun 22.

Department of Orthopaedic Surgery, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.

Purpose Of Review: Although a two-stage exchange revision is reported to have a high success rate, this strategy may fail as a treatment for prosthetic joint infection (PJI). When it does, resection arthroplasty, arthrodesis, amputation, and chronic antibiotic suppression may play a role. The purpose of this review is to determine which are the main risk factors for a two-stage exchange failure and to analyze the indications and results of resection arthroplasty, arthrodesis, amputation, and antibiotic chronic suppression for PJI. Read More

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An Open-label, Phase II Trial of Entospletinib (GS-9973), a Selective Spleen Tyrosine Kinase Inhibitor, in Diffuse Large B-cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2018 Jun 6. Epub 2018 Jun 6.

Willamette Valley Cancer Institute and Research Center, The US Oncology Network, Eugene, OR.

Background: Entospletinib (GS-9973) is an oral, selective inhibitor of spleen tyrosine kinase. Entospletinib monotherapy was evaluated in a multicenter, phase II study of subjects with relapsed or refractory B-cell malignancy.

Patients And Methods: The study included 43 patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Read More

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U-shape association of serum albumin level and acute kidney injury risk in hospitalized patients.

PLoS One 2018 21;13(6):e0199153. Epub 2018 Jun 21.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

Background: While an association between hypoalbuminemia and increased risk of acute kidney injury (AKI) is well-established, the risk of AKI development and its severity among patients with elevated serum albumin is unclear. The aim of this study was to evaluate the risk of AKI in hospitalized patients stratified by various admission serum albumin levels.

Methods: This single-center retrospective study was conducted at a tertiary referral hospital. Read More

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June 2018
2 Reads

Idiopathic Systemic Capillary Leak Syndrome.

Indian J Crit Care Med 2018 May;22(5):369-371

Department of Medicine, GGMC and JJ Group of Hospitals, Mumbai, Maharashtra, India.

Idiopathic systemic capillary leak syndrome (ISCLS) is a very rare life-threatening disorder characterized by recurrent episodes of hypotension, hemoconcentration, and hypoalbuminemia. It is caused by transient endothelial dysfunction, leading to plasma leakage from intravascular to interstitial space. Here, we report a case of ISCLS with recurrent episodes of capillary leak which required a long-term prophylaxis with beta-2 adrenergic receptor agonist and theophylline. Read More

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Early postoperative hypoalbuminemia is a risk factor for postoperative acute kidney injury following hip fracture surgery.

Injury 2018 May 2. Epub 2018 May 2.

Department of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Introduction: Acute kidney injury (AKI) is a common and serious complication after hip fracture surgery in older adults. Hypoalbuminemia is a known independent risk factor for AKI. However, few studies have investigated the relationship between early postoperative hypoalbuminemia and AKI after hip fracture surgery. Read More

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May 2018
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The Impact of Nutritional Status and Complete Blood Count Parameters on Clinical Outcome in Geriatric Critically Ill Patients.

J Clin Med Res 2018 Jul 4;10(7):588-592. Epub 2018 Jun 4.

Department of Family Medicine, Karabuk University, Medical Faculty, Karabuk, Turkey.

Background: The geriatric population in intensive care units (ICUs) has recently increased. The aim of this study was to analyse the impact of initial complete blood count (CBC)-related parameters and nutritional status on morbidity and mortality in geriatric ICU patients.

Methods: A retrospective analysis was made of geriatric patients admitted to our tertiary adult ICU for 1 year. Read More

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July 2018
4 Reads

Epstein Barr virus infection was associated with nephrotic syndrome, severe thrombocytopenia and coombs positive haemolytic anaemia.

Acta Paediatr 2018 Jun 14. Epub 2018 Jun 14.

Edith Wolfson Medical Center, Department of Paediatrics, Holon, Israel.

Epstein Barr virus (EBV) infections include a wide spectrum of clinical manifestations, ranging from asymptomatic to multiple organ involvement (1). Several complications have been described and renal involvement is usually nephritic and not nephrotic. Nephritic includes haematuria, proteinuria, renal impairment and salt retention causing hypertension and oedema, while nephrotic is defined as heavy proteinuria, with a protein/creatinine ratio of >200 mg/mmol, hypoalbuminemia of <25 g/L and oedema (2-4). Read More

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June 2018
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Should patients with hypoalbuminemia undergo LVAD implantation?

Authors:
Harold L Lazar

J Card Surg 2018 Jun 13. Epub 2018 Jun 13.

Division of Cardiac Surgery, Boston University School of Medicine, Boston, Massachusetts.

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Anesthetic Considerations for a Patient With Chronic Systemic Capillary Leak Syndrome: A Case Report.

A A Pract 2018 Jun 11. Epub 2018 Jun 11.

From the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Systemic capillary leak syndrome (SCLS) is an idiopathic vascular hyperpermeability that leads to profound hypotension, hypoalbuminemia, and hemoconcentration. Sixty years since its inauguration into literature, SCLS is still elusive, underdiagnosed, and profoundly dangerous. Few authors have documented anesthetic implications of classical acute SCLS, a form with complete recovery between exacerbations. Read More

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Relationship of central venous pressure to body fluid volume status and its prognostic implication in patients with acute decompensated heart failure.

J Card Fail 2018 Jun 8. Epub 2018 Jun 8.

Department of Cardiology, Amagasaki Chuo Hospital, 1-12-1 Shioe, Amagasaki, Hyogo 661-0976, Japan. Electronic address:

Background: Although central venous pressure (CVP) is a surrogate measure of preload in patients with acute decompensated heart failure (ADHF), it is a multifactorial index influenced not only by fluid volume status, but also by cardiac pump function and other factors. We aimed to elucidate the individual pathophysiologic factors of CVP elevation in ADHF patients by assessing the relationship between CVP and extracellular fluid volume status (EVS).

Methods And Results: We quantified EVS in 100 ADHF patients using bioelectrical impedance analysis. Read More

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Kawasaki Disease Shock Syndrome; A Unique and Severe Subtype of Kawasaki Disease.

Pediatr Int 2018 Jun 11. Epub 2018 Jun 11.

Clinical Immunology Department, Instituto Nacional de Pediatria, Mexico.

Background: Kawasaki disease shock syndrome (KDSS) is an uncommon presentation of Kawasaki disease (KD). KDSS has been associated with more severe markers of inflammation, coronary abnormalities and IVIG resistance.

Methods: A retrospective, descriptive study of children with KDSS in two hospitals was performed. Read More

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June 2018
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Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial.

Clin Nutr 2018 May 29. Epub 2018 May 29.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA. Electronic address:

Background & Aims: Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation.

Methods: We conducted a secondary analysis of a random sub-cohort sample (n = 270) from a multinational randomized trial of cART regimen efficacy among 1571 cART-naïve adults. Read More

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May 2018
2 Reads

Feline large-cell lymphoma following previous treatment for small-cell gastrointestinal lymphoma: incidence, clinical signs, clinicopathologic data, treatment of a secondary malignancy, response and survival.

J Feline Med Surg 2018 Jun 1:1098612X18779870. Epub 2018 Jun 1.

1 The Cancer Institute, Animal Medical Center, New York, NY, USA.

Objectives Lymphoma is a common and clinically important malignancy in cats. Development of a second malignancy has been reported previously in 7-14% of cats with small-cell gastrointestinal (GI) lymphoma. The aim of our study was to describe the incidence, clinical signs, clinicopathologic data, response to therapy and outcomes in cats diagnosed with large-cell lymphoma following treatment for small-cell GI lymphoma. Read More

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Aminoacyl-tRNA synthetase deficiencies in search of common themes.

Genet Med 2018 Jun 6. Epub 2018 Jun 6.

Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands.

Purpose: Pathogenic variations in genes encoding aminoacyl-tRNA synthetases (ARSs) are increasingly associated with human disease. Clinical features of autosomal recessive ARS deficiencies appear very diverse and without apparent logic. We searched for common clinical patterns to improve disease recognition, insight into pathophysiology, and clinical care. Read More

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Human Serum Albumin is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication.

J Infect Dis 2018 Jun 2. Epub 2018 Jun 2.

2nd Infectious Diseases Division, National Institute for Infectious Diseases "L. Spallanzani", Roma, Italy.

The pathogenic effects of Clostridium difficile are primarily attributable to the production of the large protein toxins A (TcdA) and B (TcdB). These toxins monoglucosylate Rho GTPases in the cytosol of host cells, causing destruction of the actin cytoskeleton with cytotoxic effects. Low human serum albumin (HSA) levels indicate a higher risk of acquiring and developing a severe C. Read More

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Association of admission vs. nadir serum albumin concentration with short-term treatment outcomes in patients with acute heart failure.

J Int Med Res 2018 Jan 1:300060518777349. Epub 2018 Jan 1.

2 LAC+USC Medical Center, Los Angeles, CA, USA.

Objectives Hypoalbuminemia occurs in 25% to 76% of patients hospitalized for acute heart failure (HF) and is associated with increased mortality. Hypoalbuminemia may predispose patients to intravascular volume depletion, hypotension, and acute worsening of renal function; however, its association with treatment outcomes during hospitalization is unknown. Methods This retrospective cohort study involved 414 adult patients hospitalized for HF requiring intravenous diuretics. Read More

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January 2018

Caspofungin dosage adjustments are not required for patients with Child-Pugh B or C cirrhosis.

J Antimicrob Chemother 2018 Jun 1. Epub 2018 Jun 1.

Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Controversies remain over caspofungin dosage adjustments in cirrhosis, particularly Child-Pugh (CP) B or C. The product information for of caspofungin recommends a maintenance dose reduction from 50 to 35 mg for patients with CP-B cirrhosis.

Objectives: To quantify the impact of cirrhosis and the severity of hepatic impairment on the pharmacokinetics (PK) of caspofungin. Read More

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June 2018
2 Reads

Diagnostic challenges of celiac disease in a young child: A case report and a review of the literature.

Medicine (Baltimore) 2018 Jun;97(22):e10893

Department of Pediatrics III, University of Medicine and Pharmacy Tîrgu Mureş, Tirgu Mures, Romania.

Rationale: Celiac disease is a chronic, immune-mediated, multiorgan disorder that affects susceptible individuals, and it is triggered by gluten and other prolamins.

Patient Concerns: We present the case of a 1-year-old male child, with a history of idiopathic pericardial effusion, admitted in our clinic for severe abdominal bloating, irritability, loss of appetite and intermittent diarrheic stools. The clinical findings were: influenced general status, irritability, distended abdomen, and diffuse abdominal tenderness. Read More

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Polymorphisms in the promoter region of the gene as a predictive factor for the first-line CTD therapy in multiple myeloma patients.

Oncotarget 2018 May 8;9(35):24054-24068. Epub 2018 May 8.

Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland.

Cereblon is a primary molecular target for immunomodulatory drugs. The aim of this study was to evaluate the influence of selected clinical and molecular factors including single nucleotide polymorphisms (SNPs) in gene on the efficacy of first line CTD (cyclophosphamide, thalidomide, dexamethasone) chemotherapy in patients with multiple myeloma. Study group consisted of 68 patients. Read More

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Colonic Abnormalities in Manitoban Children with Gastritis.

Gastroenterol Res Pract 2018 2;2018:6840390. Epub 2018 Apr 2.

Section of Pediatric Gastroenterology, Departments of Pediatrics and Pathology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Objectives: Association between and colonic pathology is underinvestigated. The aim of this work was to examine the prevalence and nature of colonic changes in children diagnosed with gastritis.

Methods: A comprehensive retrospective review of the medical records for all Manitoban children (≤17 years) diagnosed with gastritis from January 1996 to May 2015 was conducted. Read More

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Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India.

J Trop Pediatr 2018 May 23. Epub 2018 May 23.

Department of Pediatric Medicine, Institute of Postgraduate Medical Education & Research (I.P.G.M.E.& R.), 244, AJC Bose Road, 700020 Kolkata, India.

Objective: The aim of this study was to assess the clinico-laboratory parameters, complications and therapeutic responses in children with scrub typhus in Eastern India.

Materials And Methods: In this prospective, observational study, all children (age, <12 years) with suspected scrub typhus with a compatible clinical scenario were enrolled consecutively over six months. Cases confirmed by means of a positive IgM serology or a positive Weil-Felix reaction (OXK = 1/80 or above) were administered enteral doxycycline (4. Read More

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May 2018
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Liddle's-like syndrome associated with nephrotic syndrome secondary to membranous nephropathy: the first case report.

BMC Nephrol 2018 May 23;19(1):122. Epub 2018 May 23.

Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, 1-4-1, Morioka, 020-0066, Japan.

Background: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria. Read More

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May 2018
2 Reads

Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV.

J Bras Pneumol 2018 Apr;44(2):118-124

Universidade do Estado do Amazonas, Manaus, AM, Brazil.

Objective: To identify factors predictive of mortality in patients admitted to the ICU with tuberculosis (TB)/HIV coinfection in the Manaus, Amazon Region.

Methods: This was a retrospective cohort study of TB/HIV coinfected patients over 18 years of age who were admitted to an ICU in the city of Manaus, Brazil, between January of 2011 and December of 2014. Sociodemographic, clinical, and laboratory variables were assessed. Read More

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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin.

J Vis Exp 2018 05 6(135). Epub 2018 May 6.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University Tübingen; German Center for Diabetes Research (DZD), University Tübingen;

Nephrotic syndrome is the most extreme manifestation of proteinuric kidney disease and characterized by heavy proteinuria, hypoalbuminemia, and edema due to sodium retention and hyperlipidemia. To study the pathophysiology of this syndrome, rodent models have been developed based on the injection of toxic substances such as doxorubicin causing podocyte damage. In mice, only few strains are susceptible to this model. Read More

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May 2018
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Therapeutic drug monitoring of vedolizumab in inflammatory bowel disease: current data and future directions.

Therap Adv Gastroenterol 2018 8;11:1756284818772786. Epub 2018 May 8.

Department of Gastroenterology and Immunology, University Hospital of Saint Etienne, Saint Etienne, France.

The introduction of vedolizumab, a lymphocyte adhesion inhibitor, has expanded the relatively limited therapeutic armamentarium available for Crohn's disease and ulcerative colitis. Despite its effectiveness, both primary nonresponse and secondary loss of response to vedolizumab do occur, as is observed with the use of anti-tumour necrosis factor (TNF) therapy. Further, in a proportion, onset of efficacy may be relatively slow. Read More

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May 2018
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Phase II Study of Irinotecan Plus Panitumumab as Second-Line Therapy for Patients with Advanced Esophageal Adenocarcinoma.

Oncologist 2018 May 16. Epub 2018 May 16.

Vanderbilt University, Nashville, Tennessee, USA

Lesson Learned: Panitumumab plus irinotecan is not active for the treatment of esophageal adenocarcinoma.

Background: Esophageal adenocarcinoma (EAC) is a lethal cancer with increasing incidence. Panitumumab (Pa) is a fully humanized IgG2 monoclonal antibody against human EGFR. Read More

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May 2018
2 Reads

Prevalence of hypoalbuminemia in outpatients with HIV/AIDS.

Rev Soc Bras Med Trop 2018 Mar-Apr;51(2):203-206

Programa de Pós-Graduação em Doenças Infecciosas e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Hypoalbuminemia may predict progression of disease and mortality in patients with human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS). This study was conducted to investigate the risk factors associated with hypoalbuminemia in outpatients with HIV/AIDS.

Methods: A cross-sectional study was performed in 196 outpatients with HIV/AIDS. Read More

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Dose-finding study of intensive weekly alternating schedule of docetaxel, 5-fluorouracil, and oxaliplatin, FD/FOx regimen, in metastatic gastric cancer.

Oncotarget 2018 Apr 17;9(29):20339-20350. Epub 2018 Apr 17.

Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy.

Introduction: Proper administration timing, dose-intensity, efficacy/toxicity ratio of triplet docetaxel (DTX), 5-fluorouracil (5-FU), and oxaliplatin (OXP) should be improved to safely perform three-drugs intensive first line in advanced gastric cancer (GC). This dose-finding study investigated recommended 5-FU and OXP doses, safety of triplet regimen and preliminary activity.

Methods: Schedule: 12h-timed-flat-infusion 5-FU 700-1000 mg/m/d 1-2, 8-9, 15-16, 22-23, with 100 mg/m/d increase for dose level; DTX 50 mg/m d 1, 15 fixed dose, OXP at three increasing dose-levels 60-70-80 mg/m d 8, 22, every 4 weeks. Read More

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April 2018
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Successful Brincidofovir Treatment of Metagenomics-Detected Adenovirus Infection in a Severely Ill STAT1-Deficient Patient.

Pediatr Infect Dis J 2018 May 4. Epub 2018 May 4.

The Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

A STAT1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including of osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation. Read More

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May 2018
3 Reads

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR).

PLoS One 2018 8;13(5):e0196955. Epub 2018 May 8.

Division of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa, Japan.

Background: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR).

Methods: This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. Read More

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Malnutrition and chronic inflammation as risk factors for sarcopenia in elderly patients with hip fracture.

Asia Pac J Clin Nutr 2018 ;27(3):527-532

Department of Preventive Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Jinju, Korea.

Background And Objectives: To evaluate malnutrition and chronic inflammation as risk factors for sarcopenia in elderly patients with hip fractures, as defined by the criteria of the Asian Working Group on Sarcopenia (AWGS).

Methods And Study Design: A total of 327 elderly patients with hip fractures were enrolled in this retrospective observational study. The main outcome measure was the nutritional status and nutritional risk factors for sarcopenia in elderly patients. Read More

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January 2018
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The Outcome of Colorectal Surgery in Cirrhotic Patients: A Case Match Report.

Chirurgia (Bucur) 2018 Mar-Apr;113(2):210-217

Colorectal surgery in cirrhotic patients has had limited indications, but as the study aims to show, careful evaluation of risk factors can extend boundaries. From January 2011 to January 2016, using a case match cohort, 68 patients with colorectal malignancy and cirrhosis were compared against 136 persons with no liver disease. Significant risk criteria, morbidity and mortality were evaluated. Read More

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A Case of Anti-Glomerular Basement Membrane Antibody-Positive Systemic Lupus Erythematosus with Pulmonary Hemorrhage Successfully Treated at an Early Stage of the Disease.

J Nippon Med Sch 2018 ;85(2):138-144

Department of Nephrology, Nippon Medical School.

We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Read More

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January 2018

Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis.

Pediatr Int 2018 May 5. Epub 2018 May 5.

Istanbul Aydın University, Faculty of Medicine, Department of Pediatric Nephrology, Istanbul, Turkey.

Background: Acute post-streptococcal glomerulonephritis (APSGN) is the most common postinfectious glomerulonephritis in childhood. In this study, we aimed to determine the possible risk factor(s), responsible for decreased glomerular filtration rate (GFR) in APSGN.

Methods: The data of patients followed up with the diagnosis of APSGN in the Pediatric Nephrology Clinic of Gaziantep University Hospital between October 2014 and October 2016 were retrospectively evaluated. Read More

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Opportunistic infections in end stage liver disease.

Infect Dis Rep 2018 Mar 3;10(1):7621. Epub 2018 Apr 3.

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Italy.

Liver cirrhosis is the 10th most common cause of death in Western world and infection is associated with a high morbidity and mortality, and represents the leading cause of acute liver decompensation. Patients with end-stage liver disease exhibit an important impairment of immune system. This condition, called cirrhosis-associated immune dysfunction, summarizes both local and systemic immune system alterations in liver cirrhosis that play a pivotal role in determining both the high incidence of infections and the ominous infections related mortality in this population. Read More

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A Viral Polymyositis Masquerade: Life-Threatening Case of Juvenile Dermatomyositis Complicated by Systemic Capillary Leak Syndrome.

Ann Indian Acad Neurol 2018 Jan-Mar;21(1):70-74

Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

This is a case report of an 8-year-old boy who developed an atypical, rare subphenotype of autoimmune inflammatory acute juvenile dermatomyositis (JDM), initially masquerading as viral polymyositis (PM)-like presentation, that was complicated by a hitherto unreported fulminant, life-threatening pediatric systemic capillary leak syndrome (SCLS). We highlight the close differential between viral PM and JDM, the baffling clinical syndromic constellation of hypotension with hemoconcentration - a "shock"-like syndrome, hypoalbuminemia without albuminuria, and generalized edema with the atypical JDM presentation, and stress crucial need to implement early aggressive, multipronged immunomodulatory treatment along with intensive fluid resuscitation which saved the life, this patient from a stormy, and turbulent 4-week clinical illness. This is the first published case description in the current literature of the association of an aggressive subphenotype of JDM and life-threatening pediatric SCLS. Read More

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May 2018
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A Retrospective Cohort Study to Determine Predictive Factors for Abdominal Wound Disruption Following Colorectal Surgery.

Ostomy Wound Manage 2018 Apr;64(4):22-29

Abdominal wound disruption (AWD) is a postoperative complication that increases length of hospital stay, mortality, and cost. A retrospective cohort study was conducted to identify predictors of AWD, defined in the National Surgical Quality Improvement Program User Guide as a spontaneous reopening of a previously surgically closed (midline) wound that occurs within 30 days after index elective surgery in patients undergoing colorectal surgery. Data from the American College of Surgeons National Surgical Quality Improvement Program (2006-2012) were searched, supplemented by institutional review board-approved chart review. Read More

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[Calcitriol induced hypercalcemia in a hunting dog with a disseminated Paecilomyces variotii infection].

Schweiz Arch Tierheilkd 2018 May;160(5):313-319

Klinik für kleine Haustiere, Fachbereich Veterinärmedizin, Freie Universität Berlin.

Introduction: A 5-year old hunting dog was presented with reduced appetite, weight loss and polyuria/polydipsia. Hematology and clinical chemistry revealed anemia, leukocytosis, increased liver enzymes, hypoalbuminemia and hypercalcemia. The cytological, pathohistological and microbiological examination identified a disseminated infection with the saprophytic mould fungus Paecilomyces variotii in the biopsies of the spleen and a lymph node. Read More

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A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis.

Intern Med 2018 Apr 27. Epub 2018 Apr 27.

Department of Nephrology, Kyoto University, Graduate School of Medicine, Japan.

A 58-year-old man with type 1 autoimmune pancreatitis was referred to nephrologists for severe proteinuria. Laboratory data revealed a high serum IgG4 level, hypoalbuminemia, and massive proteinuria, which were compatible with nephrotic syndrome. The renal pathological findings confirmed the diagnosis of secondary membranous nephropathy concurrent with IgG4-related tubulointerstitial nephritis. Read More

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Quality of life and depression in haemodialysis patients.

Psychol Health Med 2018 Apr 29:1-10. Epub 2018 Apr 29.

a School of Medicine , Federal University of Alagoas , Maceió , Brazil.

Chronic kidney disease is associated with a high prevalence of depression, which increases inversely with the glomerular filtration rate. This paper aims to evaluate the factors associated with a low quality of life and depression in patients on haemodialysis. Two hundred patients undergoing haemodialysis answered the Medical Outcomes Study 36 - Item Short - Form Health Survey (SF-36) and Beck Depression Inventory (BDI). Read More

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Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients.

Int J Antimicrob Agents 2018 Apr 26. Epub 2018 Apr 26.

Department of Hospital Pharmacy & Clinical Pharmacology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

External validation of population pharmacokinetic (PK) models is warranted before they can be clinically applied to aid in antibiotic dose selection. The primary objective of this study was to assess the predictive performance of a gentamicin population PK model in intensive care unit (ICU) patients in two independent western populations of critically ill patients.

Methods: Data were collected from the ICU where the model was developed (Academic Medical Centre, Amsterdam [AMC]) and from the Centre Hospitalier Universitaire de Nîmes (CHU Nîmes). Read More

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Hypoalbuminemia is related to inflammation rather than malnutrition in sarcoidosis.

Eur J Intern Med 2018 Jul 24;53:e14-e16. Epub 2018 Apr 24.

Division of Pulmonary, Critical Care, Sleep and Allergy, Division of Rheumatology, Department of Medicine, University of Illinois at Chicago, USA.

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Pseudoesterase activity of albumin: A probable determinant of cholesterol biosynthesis.

Med Hypotheses 2018 Jun 30;115:42-45. Epub 2018 Mar 30.

Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

The association between hypoalbuminemia and coronary artery disease is known from some time. However, the reason as to how such phenomenon is correlated remains unknown. We have observed from published scientific literature that HSA has the potential to control cholesterol biosynthesis due to its pseudoesterase activity. Read More

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June 2018
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Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice.

Hepatol Res 2018 Apr 22. Epub 2018 Apr 22.

Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Aim: As second-line therapy, regorafenib has been shown to provide a survival benefit for patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this retrospective study, we assessed the clinical outcomes of sorafenib treatment failure with regard to second-line chemotherapy.

Methods: Patients (n = 160) with advanced HCC, Child-Pugh A liver function and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 treated with sorafenib between June 2009 and September 2016 were enrolled. Read More

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[Risk factors of anastomotic leakage after anterior resection for rectal cancer and the diagnostic value of computed tomography signs in anastomotic leakage].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Apirl 25;21(4):419-424

Department of General Surgery, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the risk factors and computed tomography (CT) diagnostic accuracy of anastomotic leakage after resection of rectal cancer (Dixon).

Methods: This retrospective study was conducted in Peking University First Hospital from January 2013 to June 2015. A cohort of 452 patients with rectal cancer was enrolled in the study. Read More

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Hydroelectrolytic and infectious complications in one year of parenteral nutrition in critical care.

Rev Esp Anestesiol Reanim 2018 Apr 18. Epub 2018 Apr 18.

Grupo de Investigación en Anestesia y Cuidados Críticos, Instituto de Investigación Sanitaria Galicia SUR (ISS Galicia Sur). SERGAS-UVigo, Vigo, España; Servicio de Anestesia y Reanimación, Complexo Hospitalario Universitario de Ourense (CHUO), Sergas, Ourense, España.

Objective: Parenteral nutrition consists of the intravenous administration of macronutrients, micronutrients and electrolytes. Our objectives were to evaluate the biochemical alterations during the first ten days of initiation and to quantify the bacteremia related to the central venous catheter during the administration of parenteral nutrition.

Material And Methods: Retrospective study of incidence and prevalence. Read More

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Human serum albumin in cardiovascular diseases.

Authors:
Stephane Arques

Eur J Intern Med 2018 Jun 19;52:8-12. Epub 2018 Apr 19.

Service de Cardiologie, Centre hospitalier Edmond Garcin, Aubagne, France. Electronic address:

Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Read More

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D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.

Case Rep Hematol 2018 18;2018:3890361. Epub 2018 Feb 18.

Serviço de Hematologia Clínica, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.

Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML).

Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. Read More

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February 2018
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Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.

Pediatr Nephrol 2018 Jul 16;33(7):1269-1272. Epub 2018 Apr 16.

Dr. v. Hauner Children's Hospital, Division of Pediatric Nephrology, Ludwig-Maximilians University, Lindwurmstraße 4, 80337, Munich, Germany.

Background: Congenital nephrotic syndrome (CNS) is primarily a monogenetic disease, with the majority of cases due to changes in five different genes: the nephrin (NPHS1), podocin (NPHS2), Wilms tumor 1 (WT1), laminin ß2 (LAMB2), and phospholipase C epsilon 1 (PLCE1, NPHS3) gene. Usually CNS is not responsive to immunosuppressive therapy, but treatment with ACE inhibitors, AT1 receptor blockade and/or indomethacin can reduce proteinuria. If the disease progresses to end-stage renal disease, kidney transplantation is the therapy of choice. Read More

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July 2018
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Nutritional Insufficiency as a Predictor for Adverse Outcomes in Adult Spinal Deformity Surgery.

Global Spine J 2018 Apr 30;8(2):164-171. Epub 2017 Jun 30.

Icahn School of Medicine at Mount Sinai, New York NY, USA.

Study Design: Retrospective analysis of prospectively collected data.

Objective: The effect of malnutrition on outcomes after general surgery has been well reported in the literature. However, there is a paucity of data on the effect of malnutrition on postoperative complications during adult deformity surgery. Read More

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April 2018
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