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    5314 results match your criteria Hypoalbuminemia

    1 OF 107

    A case report of zinc phosphide poisoning: complicated by acute renal failure and tubulo interstitial nephritis.
    BMC Pharmacol Toxicol 2017 May 25;18(1):37. Epub 2017 May 25.
    National Hospital, Colombo, Sri Lanka.
    Background: Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally. Read More

    In-vivo oxidized albumin- a pro-inflammatory agent in hypoalbuminemia.
    PLoS One 2017 24;12(5):e0177799. Epub 2017 May 24.
    Faculty of Medicine in the Galilee, Bar Ilan University, Safed, Israel.
    Hypoalbuminemia of Hemodialysis (HD) patients is an independent cardiovascular risk factor, however, there is no mechanistic explanation between hypoalbuminemia and vascular injury. In the event of oxidative stress and inflammation to which HD patients are exposed, albumin is oxidized and undetected by common laboratory methods, rendering an apparent hypoalbuminemia. We wanted to show that these circulating modified oxidized albumin molecules cause direct vascular damage, mediating inflammation. Read More

    Protein-Losing Enteropathy as a Complication of the Ketogenic Diet.
    Yonsei Med J 2017 Jul;58(4):891-893
    Division of Pediatric Neurology, Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
    The ketogenic diet is an effective treatment for the patients with intractable epilepsy, however, the diet therapy can sometimes be discontinued by complications. Protein-losing enteropathy is a rarely reported serious complication of the ketogenic diet. We present a 16-month-old Down syndrome baby with protein-losing enteropathy during the ketogenic diet as a treatment for West syndrome. Read More

    Reliability of Point-of-Care Hematocrit Measurement During Liver Transplantation.
    Anesth Analg 2017 May 19. Epub 2017 May 19.
    From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
    Background: Although point-of-care (POC) analyzers are commonly used during liver transplantation (LT), the accuracy of hematocrit measurement using a POC analyzer has not been evaluated. In this retrospective observational study, we aimed to evaluate the accuracy of hematocrit measurement using a POC analyzer and identify potential contributors to the measurement error and their influence on mistransfusion during LT.

    Methods: We retrospectively collected 6461 pairs of simultaneous intraoperative hematocrit measurements using POC analyzers and laboratory devices during LTs in 901 patients. Read More

    Are Albumin Levels a Good Predictor of Mortality in Elderly Patients with Neck of Femur Fractures?
    J Nutr Health Aging 2017 ;21(6):699-703
    Simon J Harrison, Huddersfield Royal Infirmary, Acre Street, Huddersfield, HD3 3EA, United Kingdom, Tel: +44 07967 759035.
    Background: Neck of femur (NOF) fractures are associated with significant morbidity and mortality in elderly people with multiple co-morbidities; making management of this patient subgroup challenging. Predictors of an increase in morbidity and mortality would therefore provide a useful framework for the assessment and management of this demographic. Within the current literature, hypoalbuminaemia (<35g/dl) has been highlighted as being a good biochemical predictor of short-term mortality (<12 months). Read More

    [A Case of Advanced Transverse Colon Cancer with Nephrotic Syndrome Treated with Curative Resection and Complete Adjuvant Chemotherapy].
    Gan To Kagaku Ryoho 2017 May;44(5):421-424
    Dept. of Surgery, Japan Seafarers Relief Association Moji Ekisaikai Hospital.
    A 74-year-old woman was diagnosed as having transverse colon cancer after diagnosis of nephrotic syndrome caused by membranous nephropathy. Although she had hypoproteinemia and hypoalbuminemia, we judged that she had no major nutritional problem. In previous, similar case reports, the use of human serum albumin and fresh-frozen plasma was suggested to be important to avoid complications in the perioperative period. Read More

    The relationship between oxidized serum albumin and blood pressure in hypoalbuminemic peritoneal dialysis patients.
    Clin Exp Hypertens 2017 May 23:1-5. Epub 2017 May 23.
    d Eliachar Research Laboratory , Galilee Medical Center , Nahariya , Israel.
    Background: Oxidative stress produces molecular modifications of serum albumin that disturb its biological functions and interfere with its detection by the bromocresol green assay (BCG). Oxidative stress, inflammation, and hypoalbuminemia are common peritoneal dialysis (PD). This study aimed to evaluate the relationship between serum albumin, oxidized serum albumin (OSA), oncotic pressure, and blood pressure in hypoalbuminemic PD patients. Read More

    Total abdominal colectomy vs. restorative total proctocolectomy as the initial approach to medically refractory ulcerative colitis.
    Int J Colorectal Dis 2017 May 22. Epub 2017 May 22.
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
    Purpose: There is scant data assessing the consequences of staging restorative proctocolectomy for ulcerative colitis. The aim of the study is to compare outcomes of initial vs. staged restorative proctocolectomy. Read More

    Gastrointestinal system involvement in systemic lupus erythematosus.
    Lupus 2017 Jan 1:961203317707825. Epub 2017 Jan 1.
    1 Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing China.
    Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal (GI) system. Although GI symptoms can manifest in 50% of patients with SLE, these have barely been reviewed due to difficulty in identifying different causes. This study aims to clarify clinical characteristics, diagnosis and treatment of the four major SLE-related GI system complications: protein-losing enteropathy (PLE), intestinal pseudo-obstruction (IPO), hepatic involvement and pancreatitis. Read More

    Association of post-treatment hypoalbuminemia and survival in Chinese patients with metastatic renal cell carcinoma.
    Chin J Cancer 2017 May 18;36(1):47. Epub 2017 May 18.
    Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Rd., Pudong District, Shanghai, 200127, P. R. China.
    Background: Hypoalbuminemia adversely affects the clinical outcomes of various cancers. The purpose of this study was to estimate the prognostic value of hypoalbuminemia 3-5 weeks after treatment in patients with metastatic renal cell carcinoma (mRCC) who received sorafenib or sunitinib as first-line treatment.

    Methods: In this single-center, retrospective study, we assessed the progression-free survival (PFS) and overall survival (OS) of 184 mRCC patients who received first-line sorafenib or sunitinib treatment. Read More

    Prognostic value of hypoalbuminemia for adverse outcomes in patients with rheumatic heart disease undergoing valve replacement surgery.
    Sci Rep 2017 May 16;7(1):1958. Epub 2017 May 16.
    Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
    High-risk patients with rheumatic heart disease (RHD) who were undergoing valve replacement surgery (VRS) were not identified entirely. This study included 1782 consecutive patients with RHD who were undergoing VRS to explore the relationship between hypoalbuminemia and adverse outcomes and to confirm whether hypoalbuminemia plays a role in risk evaluation. A total of 27. Read More

    Long-term outcomes in children with chronic kidney disease stage 5 over the last 40 years.
    Arch Med Sci 2017 Apr 20;13(3):635-644. Epub 2017 Apr 20.
    Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: We evaluated outcomes in children with chronic kidney disease stage 5 (CKD 5) treated in the first pediatric dialysis unit in Poland during 1973-2012.

    Material And Methods: The retrospective analysis included 208 children with CKD 5 undergoing renal replacement therapy (RRT), stratified into four decades of treatment: 1973-1982, 1983-1992, 1993-2002, and 2003-2012.

    Results: The most common causes of CKD 5 included glomerulonephritis in 27. Read More

    Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome.
    J Pak Med Assoc 2017 May;67(5):799-801
    Bezmialem Vakif University, Istanbul, Turkey.
    Congenital nephrotic syndrome is a term used to describe a condition in babies who develop severe proteinuria and hypoalbuminaemia within their first three months of life. They generally have oedema and ascites from birth which, because of increased intra-abdominal pressure, can result in an umbilical hernia. The report presents a five-month old infant with congenital nephrotic syndrome who had spontaneous umbilical hernia rupture with evisceration. Read More

    High prevalence of vitamin D deficiency among children with chronic kidney disease and kidney transplant.
    Arch Argent Pediatr 2017 Jun;115(3):220-226
    Servicio de Nefrología Pediátrica, Hospital Italiano de Buenos Aires.
    Introduction: Vitamin D (25(OH)D) deficiency is common among patients with chronic kidney disease (CKD). Our objective was to establish the prevalence of 25(OH)D deficiency among children with CKD and identify risk factors. A correlation was observed between 25(OH)D and parathormone intact molecule. Read More

    Multicentric Castleman disease of hyaline vascular variant presenting with unusual systemic manifestations: a case report.
    J Med Case Rep 2017 May 14;11(1):135. Epub 2017 May 14.
    Department of Medicine, Teaching Hospital Kandy, Kandy, Sri Lanka.
    Background: Castleman disease is a rare lymphoproliferative disorder presenting with localized or disseminated lymphadenopathy and systemic manifestations. It can be categorized in numerous ways, such as unicentric versus multicentric, histopathological variants (hyaline-vascular, plasma cell, and mixed), or subtypes based on causative viral infections (human immunodeficiency virus, human herpesvirus-8, or Kaposi sarcoma herpesvirus). Presentation ranges from asymptomatic to symptoms involving multiple organs. Read More

    A Physiologically Based Pharmacokinetic Perspective on the Clinical Utility of Albumin-Based Dose Adjustments in Critically Ill Patients.
    Clin Pharmacokinet 2017 May 11. Epub 2017 May 11.
    Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
    Introduction: In hypo-albuminemia, the extent of albumin binding of a drug decreases. The resulting change in plasma protein binding only rarely leads to clinically relevant changes in unbound drug exposure. Nevertheless, in the critically ill, a tendency to increase dosing of anti-infective therapy is seen in patients experiencing hypo-albuminemia. Read More

    Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial.
    Lancet Oncol 2017 May 8. Epub 2017 May 8.
    Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
    Background: Pancreatic cancer statistics are dismal, with a 5-year survival of less than 10%, and more than 50% of patients presenting with metastatic disease. Metabolic reprogramming is an emerging hallmark of pancreatic adenocarcinoma. CPI-613 is a novel anticancer agent that selectively targets the altered form of mitochondrial energy metabolism in tumour cells, causing changes in mitochondrial enzyme activities and redox status that lead to apoptosis, necrosis, and autophagy of tumour cells. Read More

    A primary intestinal lymphangiectasia hiding the diagnosis of pleural and pericardial tuberculosis: a clinical observation.
    Pan Afr Med J 2017 23;26:89. Epub 2017 Feb 23.
    Tuberculosis Department, Moulay Youssef University Hospital, Rabat, Maroc.
    Primary intestinal lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia (particularly T-cell). The diagnosis is based on viewing the duodenal lymphangiectasia. A 20 years old female patient, treated for a primary intestinal lymphangiectasia, has consulted for anasarca. Read More

    One-Year Clinical Outcomes in an IBD Cohort Who Have Previously Had Anti-TNFa Trough and Antibody Levels Assessed.
    Inflamm Bowel Dis 2017 May 5. Epub 2017 May 5.
    *AMNCH Tallaght, Trinity Academic Gastroenterology Group, Trinity College Dublin, Ireland; and †Trinity Academic Gastroenterology Group, Trinity College Dublin, Ireland.
    Background: Loss of response (LOR) is a big concern for anti-TNFa therapies in inflammatory bowel disease. Immunomonitoring may be useful to optimize response rates and overcome secondary LOR.

    Methods: This was an observational retrospective cohort study of a group of patients with inflammatory bowel disease on infliximab (IFX) and adalimumab (ADA) who had anti-TNFa trough and antibody levels measured, during maintenance phase of treatment. Read More

    Risk Factors for Early Postoperative Small Bowel Obstruction after Elective Colon Cancer Surgery: An Observational Study of 1,244 Consecutive Patients.
    Dig Surg 2017 May 10. Epub 2017 May 10.
    Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, PR China.
    Background: Early postoperative small bowel obstruction (EPSBO) is a common complication following colon cancer surgery. EPSBO is associated with increased hospital stays, mortality rates, and healthcare costs. The purpose of this study was to identify risk factors for EPSBO following elective colon cancer surgery. Read More

    Biochemical alteration in children with idiopathic nephrotic syndrome associated with an increased risk of sensorineural hearing loss; additional insights in cochlear renal relationship.
    Int J Pediatr Otorhinolaryngol 2017 Jun 17;97:206-210. Epub 2017 Apr 17.
    Pediatrics Department, Faculty of Medicine, Menoufia University, Shebin EL-Kom, Egypt. Electronic address:
    Objectives: Children with Idiopathic Nephrotic Syndrome (INS) are at risk of hearing loss due to the adverse impact of medications and related immunological and genetic factors on both cochlea and kidney. So this work was planned to evaluate hearing status in children with INS and to clarify the possible associated risk factors by interpreting the clinical and laboratory profiles of those children.

    Methods: Ninety children with INS aged 5-14 years [30 patients with steroid-sensitive nephrotic syndrome (SSNS), 30 patients with steroid dependent/frequently relapsing nephrotic syndrome (SDNS/FRNS), and 30 patients with steroid-resistant nephrotic syndrome (SRNS)], and 90 age and sex matched normal controls were enrolled into this study. Read More

    Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study.
    J Neurosurg 2017 May 5:1-8. Epub 2017 May 5.
    Departments of 1 Anesthesiology and Pain Medicine and Laboratory for Cardiovascular Dynamics, and.
    OBJECTIVE Hypoalbuminemia is known to be independently associated with postoperative acute kidney injury (AKI). However, little is known about the association between the preoperative serum albumin level and postoperative AKI in patients undergoing brain tumor surgery. The authors investigated the incidence of AKI, impact of preoperative serum albumin level on postoperative AKI, and death in patients undergoing brain tumor surgery. Read More

    Atraumatic chylous ascites: an unusual presentation of bladder cancer.
    BMJ Case Rep 2017 May 4;2017. Epub 2017 May 4.
    Department of General Medicine, Austin Health, Heidelberg, Australia.
    We describe a case of bladder cancer presenting with atraumatic chylous ascites, which remains an extremely rare presentation of this condition. A previously well, elderly ex-smoker with no prior history of abdominal surgery was referred for investigation of progressive dyspnoea, increasing peripheral oedema and new-onset ascites, on a background of long-standing alcohol consumption (four standard drinks daily). Liver biochemistry and coagulation profile were normal apart from marked hypoalbuminaemia. Read More

    Associations of seasonal patterns and vitamin D levels with onset and flares of pediatric inflammatory bowel disease.
    Minerva Pediatr 2017 May 4. Epub 2017 May 4.
    Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel -
    Background: As inflammatory bowel disease (IBD) might be associated with environmental factors such as seasonal patterns and low vitamin D levels we aimed to assess their association with IBD onset and flares in a large cohort of children.

    Methods: The records of 623 pediatric onset IBD patients were reviewed retrospectively including age at onset, gender, severity indices, month of first symptom, and vitamin D levels at diagnosis. For a subgroup of patients, data included date of first flare and vitamin D levels during flare and remission. Read More

    Available and incoming therapies for idiopathic focal and segmental glomerulosclerosis in adults.
    J Nephrol 2017 May 3. Epub 2017 May 3.
    Unità di Nefrologia e Dialisi, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico di Milano, Milan, Italy.
    Focal and segmental glomerulosclerosis (FSGS) is a histological pattern clinically characterized by nephrotic proteinuria, hypoalbuminemia, edema and dyslipidemia. Approximately 50% of patients progress to end-stage renal disease within 5-10 years, particularly those not responding to the therapies. FSGS pathogenesis is largely unknown and therapy is symptomatic and unspecific. Read More

    Serum albumin level and hospital mortality in acute non-ischemic heart failure.
    ESC Heart Fail 2017 May 13;4(2):138-145. Epub 2017 Jan 13.
    University of Liège HospitalGIGA Cardiovascular Sciences, Acute Care Unit, Heart Failure Clinic, CHU Sart TilmanLiègeBelgium.
    Aims: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non-ischemic HF. Read More

    Outcome of All-Oral Direct-Acting Antiviral Regimens on the Rate of Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Genotype 1-Related Chronic Liver Disease.
    Oncology 2017 Apr 28. Epub 2017 Apr 28.
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan.
    Objectives: There is little information on the risk factors for hepatocellular carcinoma (HCC) and outcome of treatment with an all-oral combination of direct-acting antiviral regimens following eradication of hepatitis C virus (HCV) RNA.

    Methods: The study subjects were 1,170 patients with HCV genotype 1-related chronic liver disease treated with either NS5A inhibitor plus NS3/4A protease inhibitor (n = 707), NS5A inhibitor plus NS5B polymerase inhibitor (n = 345), or NS5A inhibitor, NS3/4A protease inhibitor plus ritonavir (n = 118), for 12-24 weeks. All patients were free of HCC before and during therapy. Read More

    Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus.
    PLoS One 2017 25;12(4):e0176457. Epub 2017 Apr 25.
    Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70. Read More

    Membrane Transport Status Does Not Predict Peritonitis Risk in Patients on Peritoneal Dialysis.
    Nephrology (Carlton) 2017 Apr 24. Epub 2017 Apr 24.
    Department of Renal Medicine, Westmead Hospital, Westmead, NSW, Australia.
    Aim: To determine whether peritoneal membrane transport status (MTS) is associated with peritonitis or poor peritoneal dialysis (PD)-related outcomes.

    Methods: This retrospective cohort study analysed data of incident adult patients on PD in Western Sydney between October 1, 2003 and December 31, 2012. Only patients who underwent peritoneal equilibration and adequacy tests within 6 months of commencement were included. Read More

    Antiangiogenesis and gene aberration-related therapy may improve overall survival in patients with concurrent KRAS and TP53 hotspot mutant cancer.
    Oncotarget 2017 May;8(20):33796-33806
    Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose: Genetic alterations such as activating KRAS and/or inactivating TP53 are thought to be the most common drivers to tumorigenesis. Therefore, we assessed phase I cancer patients with KRAS+/TP53+ mutations.

    Results: Approximately 8% of patients referred to phase I clinical trials harbored concurrent KRAS and TP53 mutations. Read More

    Clinical and laboratory factors associated with mortality in dengue.
    Trop Doct 2017 Apr 1;47(2):141-145. Epub 2017 Jan 1.
    5 Professor, Department of Microbiology, Post Graduate Institute of Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Dengue is endemic in more than 100 countries, giving rise to an increased number of deaths in the last five years in the South-East Asian region. We report our findings from a retrospective study of adults admitted with confirmed dengue at our institution. We studied the clinical and laboratory parameters associated with mortality in these patients. Read More

    Plantago asiatica L. Ameliorates Puromycin Aminonucleoside-Induced Nephrotic Syndrome by Suppressing Inflammation and Apoptosis.
    Nutrients 2017 Apr 14;9(4). Epub 2017 Apr 14.
    Hanbang Body-fluid Research Center, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Korea.
    Objective: Nephrotic syndrome, a kidney disease with a variety of causes, is mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This study was designed to evaluate the underlying mechanism of action of Plantago asiatica L. (PAL) in treating nephrotic syndrome induced by puromycin aminonucleoside. Read More

    Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.
    PLoS One 2017 18;12(4):e0175890. Epub 2017 Apr 18.
    Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.
    Background: The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus.

    Methods: From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. Read More

    Steroid Pulse Therapy for De Novo Minimal Change Disease During Pregnancy.
    Am J Case Rep 2017 Apr 18;18:418-421. Epub 2017 Apr 18.
    Department of Obstetrics and Gynecology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
    BACKGROUND Nephrotic syndrome occurs very rarely, in only about 0.01%-0.02% of all pregnancies, and de novo minimal change disease during pregnancy is especially rare. Read More

    Macrophage activation syndrome in systemic lupus erythematosus: a multicenter, case-control study in China.
    Clin Rheumatol 2017 Apr 13. Epub 2017 Apr 13.
    Department of Rheumatology and Immunology, Peking University People's Hospital and Key Laboratory of Rheumatism Mechanism and Immune Diagnosis (BZ0135) and Peking-Tsinghua Center for Life Science, Beijing, China.
    The objective of this study was to describe the clinical and laboratory characteristics, precipitating factors, treatment, and outcome of macrophage activation syndrome (MAS) complicating systemic lupus erythematosus (SLE). A multicenter case-control study was performed across six tertiary hospitals from 1997 to 2014. A total of 32 patients with SLE-associated MAS were enrolled. Read More

    Incidence and Predictors of Advanced Liver Fibrosis by a Validated Serum Biomarker in Liver Transplant Recipients.
    Can J Gastroenterol Hepatol 2017 19;2017:4381864. Epub 2017 Mar 19.
    Division of Gastroenterology and Hepatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
    Background and Aims. Serum fibrosis biomarkers have shown good accuracy in the liver transplant (LT) population. We employed a simple serum biomarker to elucidate incidence and predictors of advanced fibrosis after LT over a long follow-up period. Read More

    A Host-Dependent Prognostic Model for Elderly Patients with Diffuse Large B-Cell Lymphoma.
    Oncologist 2017 May 13;22(5):554-560. Epub 2017 Apr 13.
    Oncology Center, Nara Medical University Hospital, Nara, Japan.
    Background: Decision-making models for elderly patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) are in great demand.

    Patients And Methods: The Society of Lymphoma Treatment in Japan (SoLT-J), in collaboration with the West-Japan Hematology and Oncology Group (West-JHOG), collected and retrospectively analyzed the clinical records of ≥65-year-old patients with DLBCL treated with R-CHOP from 19 sites across Japan to build an algorithm that can stratify adherence to R-CHOP.

    Results: A total of 836 patients with a median age of 74 years (range, 65-96 years) were analyzed. Read More

    Cardiac Changes and Their Association with Fetuin-A and Fibroblast Growth Factor-23 in Children with Chronic Kidney Disease.
    Nephron 2017 Apr 13. Epub 2017 Apr 13.
    Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa.
    Aims: In children with chronic kidney disease (CKD), fetuin-A and fibroblast growth factor-23 (FGF-23) have been implicated in the mechanism and progression of several cardiac changes. This study aimed to determine the types and rates of cardiac changes in children with CKD and their association with fetuin-A, FGF-23, and other cardiovascular risk factors (CVRFs).

    Methods: This comparative cross-sectional study recruited 88 children (5-18 years): 27 CKD I with a glomerular filtration rate (GFR) >90 mL/min/1. Read More

    Giant perforated marginal ulcer after laparoscopic Roux-en-Y gastric bypass.
    BMJ Case Rep 2017 Apr 11;2017. Epub 2017 Apr 11.
    School of Surgery, The University of Western Australia, Perth, Australia.
    Perforation of a marginal ulcer (MU) is a complication of Roux-en-Y gastric bypass that can be life-threatening. We report a case of a perforated MU that presented 7 months after surgery with several interesting points for discussion. Firstly, the presentation of the ulcer was cryptic with unreliable investigations. Read More

    Correlation of hippocampal atrophy with hyperhomocysteinemia in hemodialysis patients: An exploratory pilot study.
    PLoS One 2017 10;12(4):e0175102. Epub 2017 Apr 10.
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Kamakura, Kanagawa, Japan.
    Background: Cognitive impairment is one of the important critical issues in hemodialysis (HD) patients. However, the associating factors of brain atrophy in HD patients have not been fully elucidated.

    Purpose And Methods: Brain magnetic resonance imaging (MRI) was performed in 34 of total 72 HD outpatients in our dialysis center. Read More

    Calciphylaxis: Beyond CKD-MBD.
    Nefrologia 2017 Apr 5. Epub 2017 Apr 5.
    Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
    Introduction: Calcific uraemic arteriolopathy (CUA), also called calciphylaxis, is a rare but potentially fatal vascular disorder that almost exclusively affects patients with chronic renal failure. The objective of this study was to analyse various risk factors for developing CUA and its subsequent clinical course according to the treatment received.

    Materials And Methods: A retrospective study that included patients diagnosed with CUA from December 1999 to December 2015. Read More

    Self-healing juvenile cutaneous mucinosis.
    Reumatologia 2017 22;55(1):53-56. Epub 2017 Mar 22.
    Department of Pathology National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
    Girl, aged 4 years old, began the disease with pain of the lower extremities, fever up to 38°C and signs of upper airway infection. Then the patient developed oedema and redness of the whole face, thickened skin, subcutaneous nodular foldings of the frontal, occipital, cervical and axillary regions, extensor areas of the joints; fine, hard whitish nodules in the frontal region and over interphalangeal joints of the hands, pruritus; oedemas of the ankles, knees and joints of the hands, cervical lymphadenopathy and hepatomegaly. Blood tests at the moment of the diagnosis revealed elevation of markers of inflammation as ESR and CRP, leukocytosis, thrombocytosis, hypoalbuminemia, and hyper-alfa-2-globulinemia. Read More

    Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report.
    BMC Nephrol 2017 Apr 6;18(1):127. Epub 2017 Apr 6.
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a form of renal involvement by monoclonal IgG deposits that was found in mesangial, subendothelial or subepithelial regions. The distribution of glomerular deposits was completely different from that in monoclonal immunoglobulin deposition disease. PGNMID is reported to be rarely associated with a hematological malignancy. Read More

    A Study of Haematological and Haemostasis Parameters and Hypercoagulable State in Tuberculosis Patients in Northern India and the Outcome with Anti-Tubercular Therapy.
    J Clin Diagn Res 2017 Feb 1;11(2):OC09-OC13. Epub 2017 Feb 1.
    Director- Professor, Department of Internal Medicine, Maulana Azad Medical College , New Delhi, India .
    Introduction: Tuberculosis is one of the leading infectious diseases with high morbidity and mortality in the developing countries. Tuberculosis is also rarely associated with hypercoagulable state and very limited literature is available on this association.

    Aim: To study the haematological and haemostasis laboratory parameters, to correlate the abnormalities for a hypercoagulable state and to study the outcome with anti-tubercular therapy. Read More

    CT-Guided Intranodal Lymphangiography for Postoperative Chylous Ascites.
    Cardiovasc Intervent Radiol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Surgery, Shizuoka Medical Center, 762-1 Nagasawa, Shimizucho, Suntogun, Shizuoka Pref, Japan.
    The utility and minimal invasiveness of ultrasound-guided intranodal lymphangiography have already been reported by several researchers. Although ultrasound-guided intranodal lymphangiography is known to be not technically difficult in general, a patient's edematous groin due to hypoalbuminemia resulting from chylous ascites made it too challenging to detect and prick the lymph nodes precisely. This report describes a 71-year-old female with refractory chylous ascites due to an operation for an extrahepatic bile duct cancer, who was successfully treated by computed tomography (CT)-guided intranodal lymphangiography. Read More

    Waldmann's disease: a rare cause of protein losing enteropathy in an adult patient.
    Rev Esp Enferm Dig 2017 May;109(5):385-388
    Centre Hospitalier Universitaire de Dijon.
    Primary intestinal lymphangiectasia or Waldmann's disease is an uncommon cause of protein losing enteropathy with an unknown etiology and is usually diagnosed during childhood. It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. Differential diagnosis should include erosive and non-erosive gastrointestinal disorders, conditions involving mesenteric lymphatic obstruction and cardiovascular disorders that increase central venous pressure. Read More

    Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.
    Acta Reumatol Port 2017 Mar 27. Epub 2017 Mar 27.
    Faculty of Medicine; Thammasat University.
    A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with high dose steroid, azathioprine, mycophenolate mofetil and cyclophosphamide. Read More

    Clinical and endoscopic features in patients with hospital-acquired diarrhea associated with Clostridium difficile infection.
    Rev Gastroenterol Mex 2017 Mar 28. Epub 2017 Mar 28.
    Servicio de Infectología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México; Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
    Background And Aims: Clostridium difficile (CD) is the leading cause of hospital-acquired diarrhea. Clinical and endoscopic findings are poorly described in our country. The aim of this study is to depict those findings. Read More

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