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Clin Immunol 2021 Jun 9:108776. Epub 2021 Jun 9.

Department of Pediatrics, National Defense Medical College, Tokorozawa, Japan.

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is a neurodegenerative disorder caused by mutation in the aprataxin (APTX)-coding gene APTX, which is involved in DNA single-strand break repair (SSBR). The neurological abnormalities associated with EAOH are similar to those observed in patients with ataxia-telangiectasia. However, the immunological abnormalities in patients with EAOH have not been described. Read More

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of pediatric surgery, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris, France Children's Hospital, Zagreb University Medical School, Zagreb, Croatia Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany Department of Paediatrics, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland Hôpital Timone Enfants, service de pédiatrie multidisciplinaire, Marseille, France Aix Marseille Univ, INSERM, MMG, Marseille, France Department of pediatric gastroenterology and nutrition, Hopital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France Université de Paris ; INSERM UMR1149 ; Paris, France Unidade de Gastrenterologia Pediátrica, Centro Hospitalar do Porto, Porto, Portugal Bordeaux University Hospital, Paediatric Gastroenterology Unit, CIC 1401, F-33000, Bordeaux, France Department of pediatric gastroenterology and nutrition, Hôpital Trousseau, Assistance Publique-Hopitaux de Paris, Paris, France Children's Hospital, University of Helsinki, Helsinki, Finland Centre Hospitalier Lyon Sud, Pierre Bénite, France Pediatric gastroenterology Unit, Ospedale Maggiore Carlo Alberto Pizzardi di Bologna, Bologna, Italy Sapienza University - Umberto I Hospital, Rome, Italy Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy Department of pediatrics, Hospices Civils de Lyon, Lyon, France. University Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France Department of pediatrics. Centre Hospitalier universitaire de Limoges, Limoges, France Department of pediatrics. Centre Hospitalier Universitaire Clocheville, Tours, France Department of pediatrics. University Normandie, UNICAEN, CHU de Caen Normandie, F-14000 Caen, France INSERM UMR 1073, University Rouen, F-76000 Rouen, France Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel.

Objectives: Digestive perianastomotic ulcerations (DPAU) resembling Crohn's disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe and difficult to treat.

Methods: In the absence of recommendations, we performed a large European survey among the members of the ESPGHAN working group on inflammatory bowel disease (IBD) in order to collect the experience of expert pediatric gastroenterologists on DPAU. Read More

Cardiovasc Endocrinol Metab 2021 Jun 17;10(2):146-148. Epub 2020 Sep 17.

Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia-National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

A 24-year-old male patient came to the emergency room with melena, gum bleeding and nosebleeds. This patient has a history of mechanical prosthetic mitral valve replacement for severe mitral regurgitation (MR) and consumed warfarin irregularly, but did not come back for regular check-up. Investigations showed greatly increased thyroid function and international normalised ratio (INR) was 15. Read More

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Gastroenterology, Nevill Hall Hospital, Abergavenny, UK.

A previously well 37-year-old woman attended the emergency assessment unit with symptoms of lethargy, breathlessness and peripheral oedema, whereby initial basic investigations revealed an iron deficiency anaemia and serum hypoalbuminaemia. The patient subsequently had multiple admissions to secondary care over a 2-year period due to worsening peripheral and central oedema. Investigations ruled out non-gastrointestinal causes of serum hypoalbuminaemia, such as renal, cardiac and hepatic failures. Read More

J Clin Med Res 2021 May 25;13(5):258-267. Epub 2021 May 25.

Department of Pulmonology and Critical Care, Cape Fear Valley Medical Center, Fayetteville, NC 28304, USA.

Background: Coronavirus disease 2019 (COVID-19) can cause serious complications such as multiorgan failure and death which are difficult to predict. We conducted this retrospective case-control observational study with the hypothesis that low serum albumin at presentation can predict serious outcomes in COVID-19 infection.

Methods: We included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed, hospitalized patients from March to July 2020 in a tertiary care hospital in the USA. Read More

Rev Med Interne 2021 Jun 4. Epub 2021 Jun 4.

Service de réanimation des urgences, hôpital de la Timone, AP-HM, 264, rue Saint Pierre, 13005 Marseille, France.

Capillary leak syndrome (CLS) is an increasingly acknowledged multifaceted and potentially lethal disease. Initial nonspecific symptoms are followed by the intriguing CLS hallmark: the double paradox associating diffuse severe edema and hypovolemia, along with hemoconcentration and hypoalbuminemia. Spontaneous resolutive phase is often associated with poor outcome due to iatrogenic fluid overload during leak phase. Read More

Perioper Med (Lond) 2021 Jun 8;10(1):15. Epub 2021 Jun 8.

Department of Anesthesiology, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.

Background: The superiority of either the traditional or Stewart based approach to acid-base balance has focused primarily on analyzing metabolic acidemia, with little attention given to patients with neutral pH. In this study, we evaluate metabolic disturbances in patients in the immediate postoperative period focusing on patients with neutral pH, while comparing the Stewart and traditional approach.

Methods: We conducted a single center retrospective observational cohort study. Read More

J Nephrol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pediatric Metabolism and Nutrition, Cukurova University Faculty of Medicine, Adana, Turkey.

Background: Cystinosis is a lysosomal storage disease that affects many tissues. Its prognosis depends predominantly on kidney involvement. Cystinosis has three clinical forms: nephropathic infantile, nephropathic juvenile and non-nephropathic adult. Read More

World J Gastroenterol 2021 May;27(20):2657-2663

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai 9808574, Japan.

Background: Although cyclophosphamide (CPA) is the key drug for the treatment of autoimmune diseases including vasculitides, it has some well-known adverse effects, such as myelosuppression, hemorrhagic cystitis, infertility, and infection. However, CPA-associated severe enteritis is a rare adverse effect, and only one case with a lethal clinical course has been reported. Therefore, the appropriate management of patients with CPA-associated severe enteritis is unclear. Read More

Pediatr Nephrol 2021 Jun 6. Epub 2021 Jun 6.

Department of Pediatrics, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Although the concept of chronic kidney disease (CKD) in children is similar to that in adults, pediatric CKD has some peculiarities, and there is less evidence and many factors that are not clearly understood. The past decade has witnessed several additional registry and cohort studies of pediatric CKD and kidney failure. The most common underlying disease in pediatric CKD and kidney failure is congenital anomalies of the kidney and urinary tract (CAKUT), which is one of the major characteristics of CKD in children. Read More

Pancreatology 2021 May 24. Epub 2021 May 24.

Université de Paris, Department of Gastroenterology and Pancreatology, Beaujon University Hospital (APHP), Clichy, France. Electronic address:

Background: The efficacy and safety of gemcitabine and nab-paclitaxel (GnP) among elderly patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. We aimed to evaluate the safety and efficacy of GnP in this setting.

Patients And Methods: We retrospectively included all consecutive patients aged ≥65 years with histologically proven PDAC who received at least one cycle of GnP (January 2014 to May 2018) in four academic centers. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26156

Department of Emergency.

Abstract: Delirium is a common postoperative complication of patients with hip fracture, yet the risk factors for postoperative delirium in patients with hip fracture remain unclear. We aimed to evaluate the associated risk factors of postoperative delirium in patients with hip fracture, to provide evidence for formulating coping measures of postoperative delirium prevention and treatment in clinical practice.Patients undergoing surgery for hip fracture from March 1, 2018 to September 30, 2020 in our hospital were included. Read More

Vet Rec 2021 Jun 4:e452. Epub 2021 Jun 4.

Dick White Referrals, Small Animal Internal Medicine, Station Farm, London Road, Six Mile Bottom, Cambridgeshire, UK.

Background: Leptospirosis is a zoonotic disease of worldwide importance. This study describes the clinical findings and outcome of dogs diagnosed with leptospirosis in England.

Methods: Retrospective review of medical records of dogs diagnosed with leptospirosis from a single referral hospital located in Eastern England. Read More

Gut 2021 Jun 2. Epub 2021 Jun 2.

Department of Hepatology, Beaumont Hospital, Dublin, Ireland.

Clin Pract 2021 May 1;11(2):241-245. Epub 2021 May 1.

Department of Community Medicine Management, Faculty of Medicine, Shimane University, 89-1 Enya cho, Izumo 693-8501, Shimane Prefecture, Japan.

Physical examinations are critical for diagnosis and should be differentiated into static and dynamic categories. One of the static findings is white nail, such as Terry's and Lindsay's nails. Here, we report the cases of two older patients with acute diseases who had nail changes that aided evaluation of their clinical course. Read More

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):589-592

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Onset with fever and back pain, an 81-year-old man had sudden oliguria and progressively elevated serum creatine from normal range to 660 μmol/L within 1 week after receiving contrast agents, various antibiotics, and several nonsteroidal anti-inflammation drugs. Urine output recovered after supportive treatment. However, his serum creatinine level rose again soon after a temporary decline accompanied by gross hematuria with almost normal morphology, nephrotic proteinuria, and hypoalbuminemia. Read More

Sci Rep 2021 May 28;11(1):11290. Epub 2021 May 28.

Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Hypoalbuminemia is associated with vascular endothelial dysfunction and the development of chronic cardiovascular diseases. However, the relationship between serum albumin concentration and blood pressure changes remains controversial. Community-based longitudinal cohort data collected from Korean Genome and Epidemiology Study were used in this study. Read More

J Pharm Pharm Sci 2021 ;24:237-245

Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Purpose: To evaluate the safety and efficacy of remdesivir in adult patients with COVID-19.

Methods: PubMed, Embase, Scopus, Web of Science, Cochrane Library, ClinicalTrials.gov, and medRxiv databases were searched using a search strategy tailored to each database. Read More

Surg Obes Relat Dis 2021 Apr 24. Epub 2021 Apr 24.

Obesity and Metabolic Surgery Unit, Department of General Surgery, Ospedale Evangelico Betania, Naples, Italy. Electronic address:

This review evaluates the indications and outcomes of one-anastomosis/mini gastric bypass (OAGB/MGB) reversal to normal anatomy. A systematic literature search and meta-analysis was performed in PubMed, Web of Science, and Scopus for articles published by October 1, 2020, including the keywords "one anastomosis gastric bypass," "OAGB," "mini gastric bypass," "MGB," "reversal," "reverse," "malnutrition," and "reversal bariatric surgery". After examining 182 papers involving 11,578 patients, 14 studies were included. Read More

Ital J Pediatr 2021 May 26;47(1):116. Epub 2021 May 26.

Pediatric Intensive Care Unit, Department of Pediatrics, Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Guangzhou, 510630, P.R. China.

Background: Capillary leak syndrome (CLS) is a rare disease characterized by profound vascular leakage and presents as a classic triad of hypotension, hypoalbuminemia and hemoconcentration. Severe CLS is mostly induced by sepsis and generally life-threatening in newborns, especially in premature infants. Continuous renal replacement therapy (CRRT) plays an important role of supportive treatment for severe CLS. Read More

Dig Dis Sci 2021 May 25. Epub 2021 May 25.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Clinically significant ascites in acute pancreatitis (AP) is rarely encountered and is a result of multifactorial pathogenesis. Early reactionary ascites in AP usually does not require any treatment and resolves spontaneously in majority of patients. A diagnostic analysis should be performed in case of ascites developing in the latter stages with increasing pain or worsening organ failure. Read More

Obes Surg 2021 May 24. Epub 2021 May 24.

Department of general and specialized surgery - Unit of Bariatric Surgery, University of Siena, Policlinico "Le Scotte", Viale Bracci 14, 53100, Siena, Italy.

Background: Two of the most common bariatric procedures performed worldwide are Roux-en-Y gastric bypass (RYGB) and one anastomosis gastric bypass (OAGB). Comparative data regarding nutritional status are lacking and no previous study focus on malnutrition according to a validated score.

Methods: Retrospective data from a single institution were reviewed. Read More

Int J Rheum Dis 2021 Jun 24;24(6):815-827. Epub 2021 May 24.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aim: To investigate the risk factors for interstitial lung disease (ILD) and prognosis in patients with idiopathic inflammatory myopathy (IIM).

Methods: A retrospective longitudinal study was performed in patients diagnosed with IIM between January 2012 and December 2018.

Results: The study cohort included 91 men and 195 women who were classified as having dermatomyositis (DM, n = 183), polymyositis (PM, n = 77), or clinical amyopathic DM (CADM, n = 26). Read More

J Trop Pediatr 2021 05;67(2)

Department of Pediatrics, University of Health Sciences Adana City Training and Research Hospital, Adana, Turkey.

Objective: Aim of the study is to assess the clinical characteristics and treatment outcomes of multisystem ınflammatory syndrome in children (MIS-C) associated with COVID-19.

Study Design: The study comprised 52 children with MIS-C admitted to University of Health Sciences Adana City Training and Research Hospital pediatric wards from September 2020 to April 2021. Demographic characteristics and clinical data were retrospectively collected from patient files. Read More

Transplantation 2021 May 19. Epub 2021 May 19.

Faculty of Health, University of Technology Sydney, Sydney, Australia. School of Nursing and Midwifery, Western Sydney University, Sydney, Australia. School of Medicine, University of Notre Dame, Sydney, Australia. Heart and Lung Transplant Program, St Vincent's Hospital, Sydney, Australia. Consultation Liaison Psychiatry, St Vincent's Hospital, Sydney, Australia.

Background: The study aimed to determine whether the addition of cognitive impairment, depression, or both, to the assessment of physical frailty (PF) is associated with the risk of lung transplant (LTX) waitlist mortality.

Methods: Since March 2013, all patients referred for LTX evaluation underwent PF assessment. Cognition was assessed using the Montreal Cognitive Assessment and depression assessed using the Depression in Medical Illness questionnaire. Read More

Int Orthop 2021 May 22. Epub 2021 May 22.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.

Objectives: Klebsiella pneumoniae infection has been associated with alcoholic and diabetic patient populations, especially in Asian populations. K. pneumonia wound infection is common, but K. Read More

J Pediatr Gastroenterol Nutr 2021 May 18. Epub 2021 May 18.

Section of Pediatric Gastroenterology, Hepatology, & Nutrition, The University of Chicago Medical Center, Chicago, IL Section of Neonatology, The University of Chicago Medical Center, Chicago, IL Biostatistics Laboratory, The University of Chicago Medical Center, Chicago, IL.

Introduction: Selenium is an essential micronutrient that must be supplemented in infants and young children on exclusive parenteral nutrition (PN). We examined selenium status and clinical factors associated with deficiency in infants on PN.

Methods: This was a retrospective cohort study of pediatric patients receiving PN with routine monitoring of selenium status. Read More

J Hand Surg Am 2021 May 17. Epub 2021 May 17.

VOICES Health Policy Research Center, Department of Orthopaedic Surgery, Stanford University, Redwood City, CA. Electronic address:

Purpose: The purpose of this study was to test the null hypothesis that there is no association between perioperative laboratory markers (serum albumin and hemoglobin A1c [HbA1c]) and incidence of surgical site infection (SSI) after soft tissue upper extremity surgery.

Methods: We analyzed patient-level data from a large, insurance-based database containing supplemental laboratory results. We identified patients undergoing soft tissue upper extremity surgery (defined as carpal tunnel release, trigger finger release, wrist ganglion excision, cubital tunnel release, Dupuytren partial fasciectomy, or first dorsal compartment release) with serum albumin or HbA1c measurements within 90 days of surgery. Read More

Pharm Res 2021 May 19. Epub 2021 May 19.

Division of Pharmacodynamics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.

Purpose: This study evaluated the population pharmacokinetics of daptomycin in nonobese elderly patients with hypoalbuminemia and chronic kidney disease (CKD) using the glomerular filtration rate estimated from cystatin C (eGFRcys) and estimated its optimal dose.

Methods: We performed population pharmacokinetic analysis of the unbound concentrations of daptomycin. The probability of target attainment of 90% for achieving an area under the concentration-time curve of unbound daptomycin at steady state/ minimum inhibitory concentration ratio of ≥66. Read More

Cureus 2021 Apr 15;13(4):e14501. Epub 2021 Apr 15.

Department of Critical Care Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, CHN.

Aim Cardiac arrest is a global health concern with consistently high mortality. It is also a common condition seen in the intensive care unit (ICU). We aimed to investigate the importance of albumin level on admission, which is a widely available and simple test, to predict in-hospital mortality in cardiac arrest patients. Read More