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    Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis.
    Kidney Blood Press Res 2017 Nov 21;42(5):827-836. Epub 2017 Nov 21.
    Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
    Background/aims: The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM2. Read More

    Risk factors for colistin-associated nephrotoxicity and mortality in critically ill patients
    Turk J Med Sci 2017 08 23;47(4):1165-1172. Epub 2017 Aug 23.
    Background/aim: Colistin is gaining popularity against multidrug-resistant bacteria. The primary concern with colistin is its nephrotoxicity (NT). The aim of this study was to evaluate the incidence and risk factors for NT and to evaluate the risk factors for mortality in the toxicity group. Read More

    Molecular Ellipticity of Circulating Albumin-Bilirubin Complex Associates With Mortality in Patients With Severe Alcoholic Hepatitis.
    Clin Gastroenterol Hepatol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address:
    Background & Aims: Hyperbilirubinemia and hypoalbuminemia are features of hepatic dysfunction that associate with disease severity. This is because hepatic insufficiency causes hypoalbuminemia, which indirectly increases the circulating levels of free bilirubin. Circular dichroism (CD) spectroscopy can be used to quantify the molecular ellipticity (ME) of the albumin-bilirubin complex, and might associate with the severity or outcome of severe alcoholic hepatitis (SAH). Read More

    Transmission electron microscopy helpfulness in Whipple's disease masked by immunosuppressant therapy for arthritis.
    APMIS 2017 Nov 20. Epub 2017 Nov 20.
    Section of Pathology, Department of Emergency and Organ Transplantation, University 'Aldo Moro' of Bari, Bari, Italy.
    A 61-year-old woman received a diagnosis of undifferentiated non-erosive arthritis in 2010 and assumed methotrexate and steroids in 2014. After 1 year, she experienced watery diarrhea, vomiting, fever, weight loss, and severe hypoalbuminemia, thus being admitted into our Unit. Esophagogastroduodenoscopy showed duodenal lymphangiectasia and duodenal biopsy samples several foamy PAS-positive macrophages and villous subtotal atrophy. Read More

    Determinants of the Change in Arterial Stiffness in Peritoneal Dialysis Patients.
    Int Heart J 2017 Nov 17. Epub 2017 Nov 17.
    Department of Medicine II, Kansai Medical University.
    Arterial stiffness is an important risk factor for cardiovascular disease (CVD) in patients with end-stage renal failure. However, little is known about the factors that contribute to arterial rigidity in peritoneal dialysis (PD) patients. The aim of this study was to define the pattern and determinants of the longitudinal change in arterial stiffness after PD initiation. Read More

    [Initiating hemodialysis in Morocco: Impact of late referral].
    Nephrol Ther 2017 Nov 14. Epub 2017 Nov 14.
    Service de néphrologie, dialyse et transplantation rénale, hôpital militaire d'instruction Mohammed V, boîte postale 10000, Rabat, Maroc.
    Introduction: End-stage renal disease (ESRD) is a major public health concern in Morocco with an incidence in constant progression according to MAGREDIAL "Morocco Dialysis Registry". Patients are often sent late to nephrologists, which is a source of complications recognized in several countries. For these reasons, we tried to evaluate, in our context, the prevalence and factors of this late referral (LR). Read More

    Nutritional Status After Total Gastrectomy for Gastric Cancer.
    World J Oncol 2010 Apr 30;1(2):87-90. Epub 2010 Apr 30.
    Medical Oncology Service, Clinical University Hospital, C/ Ramon y Cajal s/n, 47005, Valladolid, Spain. Email:
    Background: Gastric cancer is one of the most frequent causes of death secondary to cancer in the world. Surgery is the only potentially curative treatment but its clinical consequences are significant. The objective of this study is to evaluate the nutritional state of patients with a total gastrectomy secondary to gastric adenocarcinoma. Read More

    Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis.
    Can J Gastroenterol Hepatol 2017 24;2017:5297143. Epub 2017 Sep 24.
    Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Background And Aims: To investigate the association between serum albumin levels within 24 hrs of patient admission and the development of persistent organ failure in acute pancreatitis.

    Methods: A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. Read More

    [Treatments of steroid-dependent nephrotic syndrome in children].
    Arch Pediatr 2017 Nov 13. Epub 2017 Nov 13.
    Service de néphrologie pédiatrique, centre de référence du syndrome néphrotique idiopathique, institut Imagine, université Paris Descartes, hôpital Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.
    Primary nephrotic syndrome (NS) is the most common glomerular disease in children. It is characterized by massive proteinuria and hypoalbuminemia. It typically has a sudden onset and more than 70% of patients will experience at least one relapse. Read More

    Capillary Leak Syndrome Following Snakebite Envenomation.
    Indian J Crit Care Med 2017 Oct;21(10):698-702
    Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
    Capillary leak syndrome is a unique complication that follows Russell's viper envenomation. This syndrome has a very high fatality rate and is characterized by parotid swelling, chemosis, periorbital edema, hypotension, albuminuria, hypoalbuminemia, and hemoconcentration. This syndrome is frequently recognized from the southern parts of India, especially from the state of Kerala. Read More

    Clinical characteristics and outcomes of Castleman disease: a multicenter study of 185 Chinese patients.
    Cancer Sci 2017 Nov 9. Epub 2017 Nov 9.
    Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine.
    Castleman disease (CD) is a rare lymphoproliferative disorder. To assess the clinical features, outcomes, and prognostic factors of this disease, we retrospectively analyzed 185 HIV-negative CD patients from four medical centers in southern China. The median age was 37 years. Read More

    Risk factors for three-month mortality after discharge in a cohort of non-oncologic hospitalized elderly patients: Results from the REPOSI study.
    Arch Gerontol Geriatr 2017 Nov 6;74:169-173. Epub 2017 Nov 6.
    ASST Papa Giovanni XXIII, Bergamo, Italy.
    Background: Short-term prognosis, e.g. mortality at three months, has many important implications in planning the overall management of patients, particularly non-oncologic patients in order to avoid futile practices. Read More

    Preoperative and Postoperative Assessments of Biochemical Parameters in Patients with Severe Obesity Undergoing Laparoscopic Sleeve Gastrectomy.
    Obes Surg 2017 Nov 8. Epub 2017 Nov 8.
    Faculty of Medicine-Endocrinology, Memorial University of Newfoundland, St. John's, NL, A1B 3V6, Canada.
    Background: The study aim was to determine the prevalence of abnormal serum biochemistries associated with micronutrient deficiencies before and after laparoscopic sleeve gastrectomy (LSG).

    Methods: Two hundred and one patients had LSG surgery between May 2011 and May 2014. Using a prospective cohort study design, data were collected on ferritin, hemoglobin (Hgb), mean cell volume (MCV), calcium, albumin, 25-hydroxyvitamin D (25-OH-D), PTH, and vitamin B12 with follow-up of 75. Read More

    Gastrointestinal parasitic infections in Indian Gaddi (goat) breed bucks: clinical, hemato-biochemical, parasitological and chemotherapeutic studies.
    J Parasit Dis 2017 Dec 26;41(4):1059-1065. Epub 2017 Jun 26.
    Department of Veterinary Public Health and Epidemiology, College of Veterinary Sciences, LUVAS, Hisar, India.
    The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II. Read More

    Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.
    J Am Soc Nephrol 2017 Nov 7. Epub 2017 Nov 7.
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York;
    Podocytes contain an intricate actin cytoskeleton that is essential for the specialized function of this cell type in renal filtration. Serum response factor (SRF) is a master transcription factor for the actin cytoskeleton, but the in vivo expression and function of SRF in podocytes are unknown. We found that SRF protein colocalizes with podocyte markers in human and mouse kidneys. Read More

    Risk prediction model for major complication after hepatectomy for malignant tumour - A validated scoring system from a university center.
    Surg Oncol 2017 Dec 9;26(4):446-452. Epub 2017 Sep 9.
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China; State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China.
    Objective: To derive and validate a scoring system for major complication after hepatectomy.

    Background: Complications after hepatectomy significantly compromise survival outcomes, method to predict such risk is lacking. A reliable scoring system is therefore awaited. Read More

    The association of hypoalbuminemia with early perioperative outcomes - A comprehensive assessment across 16 major procedures.
    Am J Surg 2017 Nov 3;214(5):871-883. Epub 2016 Dec 3.
    Center for Surgery and Public Health and Division of Urologic Surgery, Brigham and Women's Hospital, Harvard Medical School, One Brigham Circle, Boston, 02115, MA, USA.
    Background: Poor nutritional status is thought to influence peri- and postoperative outcomes. We assessed the association of hypoalbuminemia, a surrogate for poor nutritional status, with perioperative outcomes in patients undergoing one of 16 major surgical procedures.

    Methods: Patients undergoing one of 16 major surgeries were identified using the ACS-NSQIP (2005-2011). Read More

    Albumin handling in different hemodialysis modalities.
    Nephrol Dial Transplant 2017 Jul 3. Epub 2017 Jul 3.
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
    Hypoalbuminemia is a major risk factor for morbidity and mortality in dialysis patients. With increasing interest in highly permeable membranes and convective therapies to improve removal of middle molecules, transmembrane albumin loss increases accordingly. Currently, the acceptable upper limit of albumin loss for extracorporeal renal replacement therapies is unknown. Read More

    A new prognostic score comprising lactate dehydrogenase, albumin and neutrophil to lymphocyte ratio to predict sensitivity to first-line chemotherapy in patients with peripheral T-cell lymphomas.
    Int J Hematol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-8-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
    No standard therapy for peripheral T-cell lymphomas (PTCLs) has been established, and treatment outcomes are poor. Upfront stem cell transplantation has been investigated in several studies, some of which have reported promising outcomes. However, some patients maintain long-term remission after chemotherapy alone. Read More

    Jekyll and Hyde of chemotherapy treatment: method for patient specific dosing of chemotherapy medications.
    Clin Exp Pharmacol Physiol 2017 Nov 2. Epub 2017 Nov 2.
    60 Woodbrook Close SW, Calgary, Alberta.
    Currently chemotherapy dosing is determined by a patient's weight, height and renal function. Dosing chemotherapy based on these parameters is generally effective, assuming all other physiological conditions are normal. In hypoalbuminemia patients a decrease in albumin often results in more severe side-effects, since this may lead to higher chemotherapy free drug levels. Read More

    Severe enteropathy with villous atrophy in prolonged mefenamic acid users - a currently under-recognized in previously well-recognized complication: Case report and review of literature.
    Medicine (Baltimore) 2017 Nov;96(44):e8445
    aDivision of Gastroenterology, Department of Internal Medicine bDepartment of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Rationale: Mefenamic acid-induced enteropathy may be an under-recognized condition because few reported cases and no review of literature to comprehensively describe all reported cases exist. From inception until February 2017, a systematic literature search identified twenty original reports of cases of mefenamic acid-induced enteropathy. Additional five cases were identified at our hospital. Read More

    ABO blood type is associated with renal outcomes in patients with IgA nephropathy.
    Oncotarget 2017 Sep 7;8(43):73603-73612. Epub 2017 Sep 7.
    Department of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    ABO blood group antigens have been reported to be associated with inflammation and infections which have been largely implicated in the onset and progression of immune-mediated diseases. This study aimed to evaluate the association between ABO blood group and progression of IgA nephropathy (IgAN). We retrospectively enrolled 919 biopsy-proven IgAN patients with a minimum follow-up of 1 year and eGFR≥15ml/min/1. Read More

    Complement activation: an atypical presentation of an atypical syndrome.
    BMJ Case Rep 2017 Oct 30;2017. Epub 2017 Oct 30.
    Medical Oncology, Houston Methodist Hospital, Houston, Texas, USA.
    A 42-year-old Hispanic female and long-distance runner was seen for evaluation of fatigue. Her physical examination showed petechiae and ecchymoses in upper extremities, abdominal distension and bilateral ankle oedema. Laboratory workup revealed anaemia, thrombocytopenia, hypoalbuminemia and proteinuria of 1. Read More

    Clinical and pharmacological hallmarks of rifapentine's use in diabetes patients with active and latent tuberculosis: do we know enough?
    Drug Des Devel Ther 2017 11;11:2957-2968. Epub 2017 Oct 11.
    Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
    Rifapentine is a rifamycin derivate approved by the US Food and Drug Administration in 1998 for the treatment of active, drug-susceptible tuberculosis (TB). In 2014, rifapentine was approved for the treatment of latent TB infection in patients at high risk of progression to active disease and is currently under evaluation by the European Medicines Agency. Expanding indications of rifapentine largely affect diabetes patients, since about one-third of them harbor latent TB. Read More

    Prospective evaluation of poly-4-hydroxybutyrate mesh in CDC class I/high-risk ventral and incisional hernia repair: 18-month follow-up.
    Surg Endosc 2017 Oct 23. Epub 2017 Oct 23.
    Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, USA.
    Background: Long-term resorbable mesh represents a promising technology for complex ventral and incisional hernia repair (VIHR). Preclinical studies indicate that poly-4-hydroxybutyrate (P4HB) resorbable mesh supports strength restoration of the abdominal wall. This study evaluated outcomes of high-risk subjects undergoing VIHR with P4HB mesh. Read More

    Effects of tolvaptan on urine output in hospitalized heart failure patients with hypoalbuminemia or proteinuria.
    Heart Vessels 2017 Oct 23. Epub 2017 Oct 23.
    Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
    Hypoalbuminemia is an independent prognostic factor in hospitalization for heart failure (HHF). Hypoalbuminemia or proteinuria is related to resistance to loop diuretics. Tolvaptan is an oral non-peptide, competitive antagonist of vasopressin receptor-2. Read More

    Impact of frailty markers on outcomes after transcatheter aortic valve replacement: insights from a Japanese multicenter registry.
    Ann Cardiothorac Surg 2017 Sep;6(5):532-537
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
    There are no standardized criteria for measuring patients' frailty. We examined prognosis based on four frailty markers [serum albumin level, grip strength, gait speed, and clinical frailty scale (CFS)] in patients who underwent transcatheter aortic valve replacement (TAVR) between October 2013 and April 2016 and were recorded in the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry. Serum albumin level was assessed by dividing patients into two groups: hypoalbuminemia or non-hypoalbuminemia according to their serum albumin level. Read More

    Anaplastic Thyroid Carcinoma Treated with Lenvatinib.
    Kurume Med J 2017 Oct 20. Epub 2017 Oct 20.
    Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Occupational and Environmental Health.
    Objective: We report a case of anaplastic thyroid carcinoma (ATC) with local recurrence and distant metastasis that responded very well to treatment with lenvatinib, a new molecular-targeted anticancer drug.

    Case Report: A 91-year-old Japanese woman presented with a 5-month history of a painless mass in her left anterior neck. She had a past history of total thyroidectomy and neck dissection for papillary carcinoma of the thyroid. Read More

    Rapunzel syndrome (gastric trichobezoar), a rare presentation with generalised oedema: case report and review of the literature.
    Paediatr Int Child Health 2017 Oct 23:1-3. Epub 2017 Oct 23.
    a Department of Paediatrics, Faculty of Medicine , Mansoura University , Mansoura , Egypt.
    Rapunzel syndrome is a rare form of gastric trichobezoar. A 4-year-old girl presented with generalised oedema and an epigastric mass. Her family was of a relatively low socio-economic background. Read More

    Preoperative severe hypoalbuminemia is associated with an increased risk of postoperative delirium in elderly patients: Results of a secondary analysis.
    J Crit Care 2017 09 29;44:45-50. Epub 2017 Sep 29.
    Department of Biostatistics, Peking University First Hospital, Beijing, China.
    Purpose: To explore the association between the severity of preoperative hypoalbuminemia and the occurrence of postoperative delirium.

    Materials And Methods: This was a secondary analysis of the database from a previously conducted clinical trial. 700 elderly patients (age ≥65years) who were admitted to intensive care unit (ICU) after noncardiac surgery were included. Read More

    Peritoneal dialysis: The unique features by compartmental delivery of renal replacement therapy.
    Med Hypotheses 2017 Oct 7;108:128-132. Epub 2017 Sep 7.
    Institute of Pathophysiology, Semmelweis University, Budapest, Hungary.
    Despite decades of research, the clinical efficacy of peritoneal dialysis (PD) remains enigmatic. We may wonder why the modality fail in some patients but perhaps the more proper question would be, why it works in so many? We know that the contribution of residual renal function (RRF), more so than in hemodialysis, is critically important to the well-being of many of the patients. Unique features of the modality include the relatively low volume of dialysate fluid needed to provide effective uremic control and the disproportionate tendency for both hypokalemia and hypoalbuminemia, when compared to hemodialysis. Read More

    Long-term nutritional impact of sleeve gastrectomy.
    Surg Obes Relat Dis 2017 Oct 18;13(10):1664-1673. Epub 2017 Jul 18.
    Department of Internal Medicine, Laval University, Quebec, Canada. Electronic address:
    Background: Sleeve gastrectomy (SG) has become a predominant bariatric procedure throughout the world. However, the long-term nutritional impact of this procedure is unknown.

    Objectives: To describe the nutritional deficiencies before and after SG and to analyze the influence of baseline weight on nutritional status. Read More

    New predictive factors of poor response to therapy in autoimmune hepatitis: role of mean platelet volume.
    Eur J Gastroenterol Hepatol 2017 Dec;29(12):1373-1379
    Departments of aTropical Medicine bClinical Pathology cPathology dNephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine eInternal Medicine Department, Mansoura University, Mansoura, Egypt.
    Background And Objectives: The response to immunosuppressive therapy in autoimmune hepatitis (AIH) is a matter of debate. The aim of this work is to identify the histological, biochemical, and clinical predictive factors of incomplete response/treatment failure to the standard treatment (prednisone with or without azathioprine) in a well-characterized series of AIH Egyptian patients.

    Patients And Methods: Of 49 AIH patients, only 36 patients completed this retrospective cohort study. Read More

    Clinical characteristics of acute fatty liver of pregnancy in a tertiary Indonesian hospital.
    J Matern Fetal Neonatal Med 2017 Oct 16:1-191. Epub 2017 Oct 16.
    a Department Obstetrics & Gynaecology , Universitas Airlangga , RSUD dr. Soetomo , Surabaya , Indonesia.
    Acute fatty liver of pregnancy (AFLP) is a rare, often autosomal recessive disorder with a major risk for maternal and perinatal mortality and morbidity. In order to achieve a more favorable outcome, awareness of its clinical signs and symptoms and early recognition are of pivotal importance. Over a 5-year period 18 patients were diagnosed with AFLP (one twin, 19 babies). Read More

    Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy - A Case Report.
    Intern Med 2017 Oct 16. Epub 2017 Oct 16.
    Department of Internal Medicine, National Defense Medical College, Japan.
    We herein describe a 69-year-old man suffering from chronic diarrhea caused by lansoprazole (LPZ)-induced collagenous colitis (CC) accompanied with protein-losing enteropathy (PLE), diagnosed by increased fecal alpha-1 antitrypsin clearance and the findings of leakage from the descending colon to the sigmoid colon on scintigraphy. MR enterocolonography (MREC) was also performed for differentiating digestive diseases, and inflamed findings were observed around the same portion as those on scintigraphy, suggesting that this region was responsible for protein loss in this case. The MREC findings improved after the cessation of LPZ, and hypoalbuminemia also improved simultaneously. Read More

    Hypoalbuminemia at Day +90 Is Associated with Inferior Nonrelapse Mortality and Overall Survival in Allogeneic Hematopoietic Cell Transplantation Recipients: A Confirmatory Study.
    Biol Blood Marrow Transplant 2017 Oct 13. Epub 2017 Oct 13.
    Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida; Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:
    Prognostic biomarkers in allogeneic hematopoietic cell transplantation (allo-HCT) are needed to improve risk assessment and help guide therapeutic and surveillance strategies to mitigate the risk of death from the procedure. We previously identified hypoalbuminemia at day +90 post-transplantation as an independent predictor of increased nonrelapse mortality (NRM) and inferior overall survival (OS) in patients with acute myelogenous leukemia and myelodysplastic syndrome who were treated with an allo-HCT. Here, we aim to confirm the prognostic significance of day +90 hypoalbuminemia in 783 patients, median age 52 years (range, 18 to 76), who received an allo-HCT for various hematologic malignancies and bone marrow failure syndromes. Read More

    Adverse Effects of the Metabolic Acidosis of Chronic Kidney Disease.
    Adv Chronic Kidney Dis 2017 09;24(5):289-297
    Medical and Research Services VHAGLA Healthcare System, UCLA Membrane Biology Laboratory and Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, CA; and Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA. Electronic address:
    The kidney has the principal role in the maintenance of acid-base balance, and therefore, a fall in renal net acid excretion and positive H(+) balance often leading to reduced serum [HCO3(-)] are observed in the course of CKD. This metabolic acidosis can be associated with muscle wasting, development or exacerbation of bone disease, hypoalbuminemia, increased inflammation, progression of CKD, protein malnutrition, alterations in insulin, leptin, and growth hormone, and increased mortality. Importantly, some of the adverse effects can be observed even in the absence of overt hypobicarbonatemia. Read More

    Prediction Accuracy of Winter-Tozer Equations to Estimate Free Phenytoin Concentrations in Non-Critically Ill Hospitalized Patients.
    Consult Pharm 2017 Aug;32(8):461-467
    Department of Pharmacy Practice, Chicago State University College of Pharmacy, Chicago, Illinois, USA.
    Objective: To assess the accuracy of the standard and revised Winter-Tozer (WT) equations of predicting free phenytoin (PHT) concentrations in non-critically ill, hospitalized patients.

    Design: Retrospective chart review.

    Setting: Single-center, large urban community hospital. Read More

    Biomarkers of Mineral and Bone Metabolism and 20-year Risk for Hospitalization with Infection: the ARIC Study.
    J Clin Endocrinol Metab 2017 Sep 27. Epub 2017 Sep 27.
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
    Context: Mineral and bone disorders (MBD) may be relevant in the etiology of infection.

    Objective: To determine whether MBD biomarkers were associated with incidence of hospitalization with infection. We also assessed the cross-sectional association between levels of MBD biomarkers and kidney function. Read More

    Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids.
    Intern Med 2017 Oct 11. Epub 2017 Oct 11.
    Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
    A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. Read More

    Hypoalbuminemia Is Associated with Septic Revisions After Primary Surgery and Post Operative Infection after Revision Surgery.
    Spine (Phila Pa 1976) 2017 Oct 9. Epub 2017 Oct 9.
    *University of California- San Francisco, Department of Orthopaedic Surgery †University of Wisconsin School of Medicine and Public Health, Department of Radiology.
    Study Design: Retrospective Database Review OBJECTIVE.: To determine (1) the relationship between hypoalbuminemia and body mass index (BMI); (2) the association between malnutrition and revision spine surgery for septic reasons; (3) the association between malnutrition and infection after aseptic revision spine surgery.

    Summary Of Background Data: Although malnutrition has been suggested to increase the risk of infection after spine surgery, evidence supporting this hypothesis is conflicting. Read More

    Malaria Is More Prevalent Than Iron Deficiency among Anemic Pregnant Women at the First Antenatal Visit in Rural South Kivu.
    Am J Trop Med Hyg 2017 Nov 10;97(5):1551-1560. Epub 2017 Oct 10.
    Center of Research in Health Policy and Systems-International Health, Université Libre de Bruxelles, Brussels, Belgium.
    Anemia is common during pregnancy and is associated with poor outcomes. Objectives were not only 1) to determine the prevalence of anemia and iron deficiency (ID) but also 2) to identify other factors associated with anemia in pregnant women from South Kivu province, in the eastern Democratic Republic of Congo. Between December 2013 and March 2014, 531 women attending the first antenatal visit in their second trimester of pregnancy were recruited. Read More

    Renal Amyloidosis Associated With Kartagener Syndrome in a Dog.
    Top Companion Anim Med 2017 Jun 9;32(2):61-65. Epub 2017 Mar 9.
    Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
    A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Read More

    Multivariate analysis of risk factors for cisplatin-induced nephrotoxicity in gynecological cancer.
    J Obstet Gynaecol Res 2017 Oct 6. Epub 2017 Oct 6.
    Department of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Aichi, Japan.
    Aim: Risk factors for cisplatin-induced nephrotoxicity (CIN) vary by population. This study aimed to assess risk factors for CIN in patients with gynecological cancer.

    Methods: Patients who underwent cisplatin-based chemotherapy for gynecological cancer between January 2009 and December 2015 at Aichi Medical University School of Medicine were included in this study. Read More

    Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.
    Blood 2017 Oct 9;130(14):1620-1627. Epub 2017 Aug 9.
    Laboratory of Molecular Biology, CCR, NCI, NIH, Bethesda, MD.
    Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter phase 1 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (N = 55). Read More

    Investigating the Use of Human Albumin in a Non-Teaching Hospital in Iran.
    Iran J Pharm Res 2017 ;16(2):817-822
    Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
    Albumin is an expensive drug which imposes relatively high cost on the health care system. Doing ABC analysis in Shahid Motahari Hospital, it was revealed that albumin is categorized in class A. Therefore, the present study aimed to evaluate the pattern of albumin use and the physicians' adherence to evidenced-based albumin guidelines in this large general non-teaching hospital in Shiraz, Iran. Read More

    Prognostic markers in feline hepatic lipidosis: a retrospective study of 71 cats.
    Vet Rec 2017 Nov 4;181(19):512. Epub 2017 Oct 4.
    Koret School of Veterinary Medicine, Hebrew University Veterinary Teaching Hospital, Hebrew University of Jerusalem, Rehovot, Israel.
    Feline hepatic lipidosis (HL) is a common, potentially life-threatening disease resulting from prolonged anorexia and increased catabolism. This retrospective study included cats diagnosed with HL based on liver cytology or histopathology (years 2004-2015), and aimed to identify clinical and laboratory parameters associated with mortality. The study included 71 cats (47 females and 24 males) and 85 control cats with non-HL diseases. Read More

    Filiarial chyluria with nephrotic-range proteinuria and associated hypoalbuminaemia and hypogammaglobulinaemia secondary to bilateral lymphorenal fistulae.
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Department of Internal Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
    A 55-year-old man of Indian descent, presented to the emergency department with a 2-year history of passing 'milky' white urine, associated with dysuria, urinary retention, bilateral flank pain and 15 kg weight loss. He had migrated to Australia from India at the age of 16, with no overseas travel since, and denied having any fevers, rigours or chills. He was found to have chyluria and nephrotic-range proteinuria with marked hypoalbuminaemia and hypogammaglobulinaemia. Read More

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