5,970 results match your criteria Hypoalbuminemia


Is low serum albumin associated with postoperative bronchopleural fistula in patients undergoing pulmonary resections?

Interact Cardiovasc Thorac Surg 2019 Mar 19. Epub 2019 Mar 19.

Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether low serum albumin (sAlb) was associated with postoperative bronchopleural fistula (BPF) in patients undergoing pulmonary resections. Altogether 660 papers were found using the reported search, of which 5 retrospective cohort studies represented the best evidence to answer the clinical question. Read More

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http://dx.doi.org/10.1093/icvts/ivz084DOI Listing

Hypoalbuminemia and the Risk of Acute Kidney Injury in Sepsis.

Crit Care Med 2019 Apr;47(4):e377-e378

Private University for Health Sciences, Medical Informatics and Technology, Executive Office, Hall in Tyrol, Austria.

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http://dx.doi.org/10.1097/CCM.0000000000003592DOI Listing

Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan.

Aging Clin Exp Res 2019 Mar 14. Epub 2019 Mar 14.

The Department of Family Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., Taipei, 104, Taiwan, ROC.

Background: Pneumonia is a leading cause of hospitalization and death worldwide. However, studies focusing on risk factors of community-acquired pneumonia (CAP) in the home health care (HHC) population remain scarce.

Aims: This study aimed to evaluate risk factors associated with hospitalization for CAP among HHC patients in Taiwan. Read More

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http://dx.doi.org/10.1007/s40520-019-01169-8DOI Listing
March 2019
2 Reads

Current Concepts in Hemodialysis Vascular Access Infections.

Adv Chronic Kidney Dis 2019 Jan;26(1):16-22

Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI.

Infection-related causes are second only to cardiovascular events for mortality among end-stage renal disease patients. This review will provide an overview of hemodialysis catheter-, graft-, and fistula-related infections with emphasis on diagnosis and management in specific settings. Use of catheters at the initiation of dialysis has remained unchanged at 80%. Read More

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http://dx.doi.org/10.1053/j.ackd.2018.10.005DOI Listing
January 2019
1 Read

The Role of Familial Mediterranean Fever Gene Mutation in Treatment of Infantile Colitis With Resistant Perianal Fistula.

Arch Rheumatol 2018 Dec 23;33(4):473-477. Epub 2018 Mar 23.

Department of Pediatric Surgery, Ege University School of Medicine, İzmir, Turkey.

Symptoms of infantile inflammatory bowel disease (I-IBD) can be life-threatening and associated with poor prognosis. The presence of Mediterranean fever (MEFV) gene mutations play an important role in treatment of I-IBD. In this article, we describe a case of I-IBD with a resistant fistula, in which remission occurred following colchicine therapy. Read More

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https://www.archivesofrheumatology.org/full-text/1014
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http://dx.doi.org/10.5606/ArchRheumatol.2018.6741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409165PMC
December 2018
2 Reads

Predictors of Initial Smear-Negative Active Pulmonary Tuberculosis with Acute Early Stage Lung Injury by High-Resolution Computed Tomography and Clinical Manifestations: An Auxiliary Model in Critical Patients.

Authors:
Jun-Jun Yeh

Sci Rep 2019 Mar 14;9(1):4527. Epub 2019 Mar 14.

Department of Pulmonary Medicine, Section of Thoracic Imaging, and Family Medicine, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chiayi, Taiwan.

This study evaluated the diagnostic use of high-resolution computed tomography (HRCT), chest X-ray (CXR), and clinical manifestations (CM) to identify initial smear-negative (iSN) active pulmonary tuberculosis (aPTB) [iSN-aPTB] in patients with iSN-pulmonary diseases (PD) and acute lung injury (ALI). In the derivation cohort, the [iSN-PD] with ALI patients were divided into the [iSN-aPTB] (G1, n = 26) and [non-aPTB-PD] (G2, n = 233) groups. Lung morphology, number, and lobar (segmental) distribution were evaluated using CXR and HRCT. Read More

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http://dx.doi.org/10.1038/s41598-019-40799-wDOI Listing
March 2019
1 Read

[Ménétrier's disease in pediatric patients secondary to cytomegalovirus infection: Presentation of two clinical cases in a high complexity center].

Arch Argent Pediatr 2019 Apr;117(2):e158-e162

Hospital Italiano de Buenos Aires.

Ménétrier's disease is a protein losing gastroenteropathy. Defined as a rare entity with an unknown cause, most of the reported cases have been associated with viral infections. In pediatric patients, it is characterized by an acute onset with a benign and self-limiting course. Read More

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http://dx.doi.org/10.5546/aap.2019.e158DOI Listing
April 2019
1 Read

Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock.

ASAIO J 2019 Mar 6. Epub 2019 Mar 6.

From the National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.

The aim of this study is to examine factors that can predict mortality in patients that have veno-arterial extracorporeal membrane oxygenation (VA-ECMO) instituted for cardiogenic shock. A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Read More

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http://dx.doi.org/10.1097/MAT.0000000000000984DOI Listing
March 2019
1 Read

Hypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma.

Caspian J Intern Med 2019 ;10(1):111-117

Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain.

Background: Enteropathy-associated T-cell lymphoma (EATL) is a rare and aggressive type of extranodal T-cell lymphoma (TCL) arising in the gastrointestinal (GI) tract and represents 5-8% of all T-cell non-Hodgkin lymphomas (NHL) and 10-25% of primary intestinal lymphomas.

Case Presentation: We reported a 78-year-old woman presenting with severe hypocalcemia. Investigations confirmed vitamin D and iron deficiency as well as hypoalbuminemia. Read More

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http://dx.doi.org/10.22088/cjim.10.1.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386331PMC
January 2019
1 Read

Musculoskeletal Manifestations as Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents.

J Pediatr 2019 Mar 8. Epub 2019 Mar 8.

Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

A comparison of 23 children with inflammatory bowel disease presenting with musculoskeletal symptoms and 46 children with arthritis of other causes yielded significantly higher rates in the inflammatory bowel disease group of sacroiliitis, arthralgia, additive and recurrent arthritis, microcytic anemia, elevated inflammatory markers, and hypoalbuminemia. Clinical awareness of these findings could expedite diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.005DOI Listing
March 2019
2 Reads

Phenotype and Genotype of a Cohort of Chinese Children with Early-Onset Protein-Losing Enteropathy.

J Pediatr 2019 Mar 7. Epub 2019 Mar 7.

Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.

Objectives: To examine the phenotypes and perform next-generation sequencing in children with early-onset protein-losing enteropathy.

Study Design: We performed a retrospective review of 27 children with early-onset protein-losing enteropathy. Patients were characterized on clinical, immunologic, and systemic involvements. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.003DOI Listing
March 2019
1 Read

Presentation of hemolytic and hemorrhagic rangeliosis in Cerdocyon thous.

Ticks Tick Borne Dis 2019 Feb 22. Epub 2019 Feb 22.

Laboratório de Diagnóstico em Medicina Veterinária, Universidade de Caxias do Sul, R. Francisco Getúlio Vargas, 1130, Petrópolis, Caxias do Sul, RS, 95070560, Brazil. Electronic address:

Rangeliosis, caused by protozoan Rangelia vitalii, is transmitted by the tick Amblyomma aureolatum. The disease is characterized by hemolytic and hemorrhagic disorder and has been described in dogs and other wild canids. The aim of this study was to compare clinicopathological findings and laboratory results of a Rangelia infection in a crab-eating fox (Cerdocyon thous) with those of canine rangeliosis. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.010DOI Listing
February 2019
1 Read

Prognostic Role of Serum Albumin, Total Lymphocyte Count, and Mini Nutritional Assessment on Outcomes After Geriatric Hip Fracture Surgery: A Meta-Analysis and Systematic Review.

J Arthroplasty 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopedics, The Seventh Medical Center of PLA General Hospital, Beijing, China.

Background: Hip fracture is a significant health risk for older adults and malnutrition indicates hip fracture risk.

Methods: We evaluated whether nutrition status could predict clinical outcomes and mortality after hip fracture surgery in older adults. MEDLINE, Cochrane, EMBASE, and Google Scholar databases were searched for studies published until July 1, 2018, in patients with serum albumin or total lymphocyte count (TLC) at admission, nutritional status by Mini Nutritional Assessment (MNA), and in-hospital follow-up. Read More

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http://dx.doi.org/10.1016/j.arth.2019.02.003DOI Listing
February 2019
1 Read

Lawsonia intracellularis associated equine proliferative enteropathy in Danish weanling foals.

Acta Vet Scand 2019 Mar 8;61(1):12. Epub 2019 Mar 8.

Large Animal Teaching Hospital, Department of Veterinary Clinical Sciences, University of Copenhagen, Agrovej 8, 2630, Taastrup, Denmark.

Background: Lawsonia intracellularis, an obligate intracellular bacterium, causes equine proliferative enteropathy, mainly in horses around weaning. This disease is rarely reported in the Scandinavian countries.

Results: Five cases of equine proliferative enteropathy were diagnosed between 2008-2016 at the University of Copenhagen Large Animal Teaching Hospital. Read More

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http://dx.doi.org/10.1186/s13028-019-0447-3DOI Listing
March 2019
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Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients.

Farm Hosp 2019 03 1;43(2):53-55. Epub 2019 Mar 1.

Servicio de Farmacia Hospitalaria, Residencia para Personas Mayores Dependientes La Cañada, Paterna, Valencia.

Objective: To analyze the interaction between acenocoumarol and  levofloxacin in the elderly. We also assessed how hypoalbuminemia affects international normalized ratio variation.

Method: Retrospective study carried on elderly institutionalized patients who were prescribed levofloxacin concomitantly with acenocoumarol. Read More

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http://dx.doi.org/10.7399/fh.11111DOI Listing
March 2019
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Glomerular disease patients have higher odds not to reach quality targets in chronic dialysis compared with CAKUT patients: analyses from a nationwide German paediatric dialysis registry.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Background: Paediatric dialysis patients still suffer from high morbidity rates. To improve this, quality assurance programs like the German QiNKid (Quality in Nephrology for Children)-Registry have been developed. In our study, the significance of underlying renal disease on a range of clinical and laboratory parameters impacting morbidity and mortality was analysed. Read More

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http://dx.doi.org/10.1007/s00467-019-04218-6DOI Listing
March 2019
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Congenital analbuminemia in a patient affected by hypercholesterolemia: A case report.

World J Clin Cases 2019 Feb;7(4):466-472

Department of Interdisciplinary Medicine, Geriatric Unit and Rare Disease Center, "Aldo Moro" University, Bari 70125, Italy.

Background: Congenital analbuminemia (CAA) is a very rare disorder. Our data describes the clinical features and laboratory results of a new case established by mutation analysis of the albumin gene in a 39-year-old woman presenting with hypercholesterolemia. Our findings contribute to shed light on the molecular genetics of the disorder and confirm that safe and well tolerated hypocholesterolemic treatment with atorvastatin may be administered in dislipidemic patient with CAA in order to reduce their cardiovascular risk. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i4.466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397822PMC
February 2019
1 Read

Refractory ascites as a presenting feature of extramedullary plasmacytoma in an end-stage renal disease patient with HIV infection.

Clin Nephrol Case Stud 2019 10;7:7-10. Epub 2019 Feb 10.

Department of Medicine, Division of Nephrology, Medical University of South Carolina.

Refractory ascites as the only presenting feature of an extramedullary plasmacytoma complicating end-stage renal disease and HIV infection has not been described yet. We describe a case of a 39-year-old female with HIV-associated nephropathy manifesting with ascites formation after transition from peritoneal dialysis (PD) to hemodialysis (HD). Earlier on, she received cycler-assisted PD for 5 years uneventfully. Read More

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http://dx.doi.org/10.5414/CNCS109560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374990PMC
February 2019
2 Reads

Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients.

Front Physiol 2019 18;10:105. Epub 2019 Feb 18.

Institute of Applied Clinical Science, Keele University, Stoke-on-Trent, United Kingdom.

It is not clear whether the association of increased peritoneal protein clearance (PPCl) with worse survival on peritoneal dialysis (PD) is a consequence of either local or systemic inflammation or indicative of generalized endothelial dysfunction associated with comorbidity. To investigate this we determined the relationship of PPCl to comorbidity, membrane area (equivalent to low molecular weight peritoneal solute transport rate), local and systemic inflammation and hypoalbuminaemia, and for each of these with patient survival. 257 incident patients from three GLOBAL Fluid Study centers were included in this analysis. Read More

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http://dx.doi.org/10.3389/fphys.2019.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387967PMC
February 2019

Unusual conservative treatment of a complicated pacemaker pocket infection: a case report.

J Med Case Rep 2019 Mar 3;13(1):49. Epub 2019 Mar 3.

The First Clinical Medical College of Jinan University, Guangzhou, 510630, China.

Background: For patients with complicated generator pocket infection, expert consensuses universally advocate complete device and leads removal followed by delayed replacement on the contralateral side. We cured our patient by partial generator removal and reimplantation of sterilized pulse generator on the ipsilateral side. We also performed a literature review about incomplete removal therapy for the management of cardiac implantable electronic device infection. Read More

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http://dx.doi.org/10.1186/s13256-019-1987-xDOI Listing
March 2019
2 Reads

Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report.

BMC Gastroenterol 2019 Feb 28;19(1):37. Epub 2019 Feb 28.

Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of the lack of an endoscopic banding ligation device for pediatric patients, EIS is usually performed for bleeding esophageal varices (EV) in infants with congenital biliary atresia.

Case Presentation: We present a case of a 15-month-old female infant with type I biliary atresia with jaundice (total serum bilirubin, 22. Read More

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http://dx.doi.org/10.1186/s12876-019-0955-7DOI Listing
February 2019
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Diabetic Retinopathy as a Risk Factor for Chronic Kidney Disease Progression: A Multicenter Case⁻Control Study in Taiwan.

Nutrients 2019 Feb 27;11(3). Epub 2019 Feb 27.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan.

It has rarely been studied whether the presence and severity of diabetic retinopathy (DR) could influence the renal disease progression among all chronic kidney disease (CKD) diabetic patients. This study investigates the characteristics of diabetic patients, with different stages of chronic kidney disease (CKD), according to the occurrence of diabetic retinopathy and determines the influence of retinopathy in the deterioration of renal function. We conduct a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of the CKD project (2008⁻2013) and the National Health Insurance Research Database (NHIRD) (2001⁻2013). Read More

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http://dx.doi.org/10.3390/nu11030509DOI Listing
February 2019
1 Read

Chylothorax after spinal fusion surgery: A case report and literature review.

Respir Med Case Rep 2019 5;26:260-264. Epub 2019 Feb 5.

Department of Respiratory Medicine, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan.

Chylothorax is reported as a postoperative complication, mainly in the field of thoracic surgery, but there are only 14 reports in the field of spinal surgery. A 64-year-old woman underwent spinal fusion surgery by the anterior and posterior approach for her scoliosis. She developed leg edema and right pleural effusion 2 months after the surgery. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378334PMC
February 2019
1 Read

Early postoperative hypoalbuminaemia is associated with pleural effusion after donor hepatectomy: A propensity score analysis of 2316 donors.

Sci Rep 2019 Feb 26;9(1):2790. Epub 2019 Feb 26.

Department of Anaesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Pleural effusion and hypoalbuminaemia frequently occur after hepatectomy. Despite the emphasis on the safety of donors, little is known about the impact of postoperative albumin level on pleural effusion in liver donors. We retrospectively assessed 2316 consecutive liver donors from 2004 to 2014. Read More

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http://dx.doi.org/10.1038/s41598-019-39126-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391412PMC
February 2019

[Analysis of risk factors of pulmonary infection in patients over 60 years of age after radical resection for gastric cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Feb;22(2):164-171

Department IV of Gastrointestinal Cancer Center, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142,China, Email:

Objective: To investigate the risk factors of postoperative pulmonary infection (PPI) in patients over 60 years of age with gastric cancer after radical gastrectomy.

Methods: Clinicopathological data of 373 patients over 60 years of age who underwent radical gastrectomy at Department IV of Gastrointestinal Cancer Center, Peking University Cancer Hospital, from April 2009 to December 2016 were retrospectively collected in this case-control study. The clinicopathological characteristics of patients with postoperative pulmonary infection (including postoperative atelectasis) and those without pulmonary infection were compared. Read More

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February 2019
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Relationship between Hypoalbuminemia on Admission and Long-term Mortality in Patients with Acute Decompensated Heart Failure.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Cardiovascular Medicine, Juntendo University School of Medicine, Japan.

Objective Although several studies have reported the relationship between hypoalbuminemia and the clinical outcome, it remains disputable in patients with acute decompensated heart failure (ADHF). We therefore investigated the relationship between hypoalbuminemia on admission and long-term mortality in hospitalized patients following ADHF. Methods We examined a cohort of 751 consecutive patients who were admitted to the cardiac intensive-care unit between 2007 and 2011 with a diagnosis of ADHF. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1716-18DOI Listing
February 2019
4 Reads

Pre-operative biomarkers and imaging tests as predictors of post-operative delirium in non-cardiac surgical patients: a systematic review.

BMC Anesthesiol 2019 Feb 23;19(1):25. Epub 2019 Feb 23.

Department of Anesthesia, Toronto Western Hospital, University Health Network, 2-434 McLaughlin Wing, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

Background: Post-operative delirium (POD) is a common post-operative complication in elderly individuals and imposes a significant health and financial burden. Identifying predictive biomarkers may help understand the pathophysiology of POD. Our objective is to summarize the evidence of pre-operative biomarkers and imaging tests to predict POD in patients undergoing non-cardiac surgery. Read More

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http://dx.doi.org/10.1186/s12871-019-0693-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387490PMC
February 2019
1 Read

A Cross-Sectional Study on Malnutrition in Inflammatory Bowel Disease: Is There a Difference Based on Pediatric or Adult Age Grouping?

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

IBD Research Group, McGill University Health Center, Montreal, Quebec, Canada; Research Centre, Sainte-Justine UHC.

Background: Malnutrition, commonly observed in inflammatory bowel disease (IBD), is associated with increased morbidity and mortality and is attributed to multiple causes. The added energy costs of growth in the child and adolescent with IBD are an additional risk factor.

Methods: The aim of the study was to perform a cross-sectional comparison of nutritional parameters in IBD between pediatric and adult cases. Read More

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http://dx.doi.org/10.1093/ibd/izy403DOI Listing
February 2019
5 Reads

Significance of Earlier Initiation of Chemotherapy for Lung Cancer Complicated with Primary or Secondary Nephrotic Syndrome following Its Appropriate Differential Diagnosis.

Case Rep Oncol 2019 Jan-Apr;12(1):53-58. Epub 2019 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosis of primary nephrotic syndrome, as opposed to paraneoplastic nephrotic syndrome. Read More

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http://dx.doi.org/10.1159/000493851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381920PMC
January 2019
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Evaluation of a Preoperative Adverse Event Risk Index for Patients Undergoing Head and Neck Cancer Surgery.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Importance: Patients 65 years or older are the most frequent users of operative resources and are also the most vulnerable to postoperative adverse events (AEs). Frailty indices are increasingly being used for preoperative risk stratification within head and neck cancer surgery, but most models lack a multifactorial basis and cannot be directly applied to clinical practice. A practical risk index is needed for clinicians to gauge risk factors preoperatively. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.4513DOI Listing
February 2019
1 Read

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients.

Gastric Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Venous thromboembolism (VTE) is highly associated with advanced gastric cancer (AGC) and is sometimes lethal. Predictors of VTE have not been identified, and the efficacy and safety of direct oral anticoagulants (DOACs) for AGC-associated VTE remain to be clarified.

Methods: A total of 188 AGC patients who started chemotherapy during the period from January 2014 to December 2017 in our institutions were retrospectively examined for the incidence of VTE, risk factors for VTE, and the efficacy and safety of DOAC-based anticoagulant therapy for VTE. Read More

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http://dx.doi.org/10.1007/s10120-019-00930-2DOI Listing
February 2019

Viral, immunologic, and clinical features of primary effusion lymphoma.

Blood 2019 Feb 19. Epub 2019 Feb 19.

HIV & AIDS Malignancy Branch, Center for Cancer Research (CCR), NCI, Bethesda, MD, United States;

Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and approximately 80% of tumors are Epstein Barr virus (EBV) co-infected. A better understanding of how KSHV-related immune dysregulation contributes to the natural history of PEL will improve outcomes. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2019-01
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http://dx.doi.org/10.1182/blood-2019-01-893339DOI Listing
February 2019
4 Reads

Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy.

Clin Exp Nephrol 2019 Feb 16. Epub 2019 Feb 16.

Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kotobashi, Sumida-ku, Tokyo, 130-8575, Japan.

Background: Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear.

Methods: In this single-center retrospective cohort study, we examined the clinical records of AKI patients requiring RRT who were hospitalized in the ICU or general wards at our hospital from January 2010 to December 2013. A priori-determined covariates of age, sex, cardiovascular disease, chronic kidney disease (CKD), mean arterial pressure (MAP), sepsis, nephrotoxic agents, and hypoalbuminemia were assessed in Cox hazard models to estimate hazard ratio (HR). Read More

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http://dx.doi.org/10.1007/s10157-019-01711-yDOI Listing
February 2019

A Novel Homozygous Truncating Mutation in Gene in a Chinese Uyghur Patient With Severe Phenotype Pierson Syndrome.

Front Med (Lausanne) 2019 4;6:12. Epub 2019 Feb 4.

Pediatric, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Pierson syndrome (OMIM 609049) is a rare autosomal recessive disorder characterized by congenital nephrotic syndrome and complex ocular abnormalities. Severe renal symptoms had be associated with truncating mutations. Few Chinese patients from diverse ethnic background had been evaluated and reported with this syndrome. Read More

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http://dx.doi.org/10.3389/fmed.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369156PMC
February 2019
1 Read

Development of Infliximab Target Concentrations during Induction in Pediatric Crohn's Disease Patients.

J Pediatr Gastroenterol Nutr 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objectives: Subtherapeutic drug concentrations contribute to both primary and secondary nonresponse to infliximab in children with Crohn's disease (CD). The aim of this study was to evaluate treatment outcomes and infliximab concentrations at infusions 2 and 3 with an objective to establish infliximab targets during induction for primary responders.

Methods: Single-center, prospective cohort of anti-TNF naïve CD patients < 22 years old starting infliximab. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002304DOI Listing
February 2019
1 Read

Comparative pathophysiology and management of protein-losing enteropathy.

J Vet Intern Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota.

Protein-losing enteropathy, or PLE, is not a disease but a syndrome that develops in numerous disease states of differing etiologies and often involving the lymphatic system, such as lymphangiectasia and lymphangitis in dogs. The pathophysiology of lymphatic disease is incompletely understood, and the disease is challenging to manage. Understanding of PLE mechanisms requires knowledge of lymphatic system structure and function, which are reviewed here. Read More

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http://dx.doi.org/10.1111/jvim.15406DOI Listing
February 2019
1 Read

Oral nutritional supplements and 30-day readmission rate in hypoalbuminemic maintenance hemodialysis patients.

Hemodial Int 2019 Jan 14;23(1):93-100. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Introduction: Hemodialysis (HD) patients are hospitalized nearly twice yearly, and 35% of these patients are rehospitalized within 30-days postdischarge. We hypothesized that monitored oral nutritional supplementation (ONS) during HD treatment may decrease readmissions.

Methods: A cohort of maintenance HD patients, treated at a large dialysis organization, who were hospitalized with a postdischarge albumin of ≤3. Read More

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http://dx.doi.org/10.1111/hdi.12694DOI Listing
January 2019
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Risk factors for peptic ulcer disease in patients with end-stage renal disease receiving dialysis.

Kidney Res Clin Pract 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Background: Compared to the general population, patients with end-stage renal disease have more gastrointestinal symptoms and a higher prevalence of peptic ulcer. Risk factors for peptic ulcer disease in patients with end-stage renal disease, however, remain poorly defined. This study aims to better identify those risk factors. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0060DOI Listing
February 2019
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Celiac crisis, a rare occurrence in adult celiac disease: A systematic review.

World J Clin Cases 2019 Feb;7(3):311-319

Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.

Background: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children.

Aim: To perform a review of CC cases reported in adult CD patients. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369385PMC
February 2019
2 Reads

Effect of preoperative low serum albumin on postoperative complications and early mortality in patients undergoing transcatheter aortic valve replacement.

J Thorac Dis 2018 Dec;10(12):6763-6770

Department of Cardiothoracic Surgery, Heartcenter, Heartcenter, University of Cologne, Cologne, Germany.

Background: Patients undergoing transcatheter aortic valve replacement (TAVR) are mostly elderly patients with substantial comorbidities. Established risk scores are not validated for TAVR and collectives with elderly patients making periprocedural risk stratification difficult. Serum albumin is known to be an indicator for malnutrition and frailty and is simple to measure, independent of physician's bias. Read More

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http://jtd.amegroups.com/article/view/25306/19460
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http://dx.doi.org/10.21037/jtd.2018.11.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344723PMC
December 2018
5 Reads

Relationship between the albumin level and the anesthesia method and the effect on clinical course in patients with major burns.

Ulus Travma Acil Cerrahi Derg 2019 Jan;25(1):55-59

Department of Anesthesiology and Reanimation, Health Sciences University Ankara Numune Training and Research Hospital, Ankara-Turkey.

Background: Due to a massive increase in capillary permeability during the state of shock caused by burns, albumin and intravascular fluid rapidly move to the extravascular areas. Therefore, hypoalbuminemia is seen as an early and prolonged finding in major burns. Hypoalbuminemia leads to various problems. Read More

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http://dx.doi.org/10.5505/tjtes.2018.71278DOI Listing
January 2019
2 Reads

Life After 90: Predictors of Mortality and Performance of the ACS-NSQIP Risk Calculator in 4,724 Nonagenarian Patients Undergoing Emergency General Surgery.

J Trauma Acute Care Surg 2019 Feb 7. Epub 2019 Feb 7.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: The decision to emergently operate on nonagenarian patients (NONAs) can be complex due to the uncertainty about outcomes and goals of care at this advanced age. We sought to study: 1) the outcomes and predictors of mortality for NONAs undergoing emergency general surgery (EGS) and 2) the accuracy of ACS-NSQIP mortality risk calculator in this special population.

Methods: Using the 2007-2015 ACS-NSQIP database, we included all patients older than 90 years of age who underwent an emergent operation with a CPT code for "digestive system". Read More

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http://dx.doi.org/10.1097/TA.0000000000002219DOI Listing
February 2019
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Protein deficiency after gastric bypass: The role of common limb length in revision surgery.

Surg Obes Relat Dis 2019 Jan 11. Epub 2019 Jan 11.

Department of International Business, Chien Hsin University of Science and Technology, Taoyuan, Taiwan, R.O.C.

Background: Bariatric surgery, especially the gastric bypass procedure, is an effective therapy for morbid obesity, but may reduce protein absorption and induce protein deficiency (PD). A recent study reported an issue about common limb length for PD.

Objective: This study aimed to examine the prevalence of PD after gastric bypass surgery and investigate the role of common limb length in PD-related revision surgery. Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.037DOI Listing
January 2019
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Prognostic value of serum albumin for patients with acute aortic dissection: A retrospective cohort study.

Medicine (Baltimore) 2019 Feb;98(6):e14486

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Serum albumin (SA) is associated with inflammation and thrombosis, which are involved in acute aortic dissection (AAD). Our aim was to investigate the effect of SA level on survival in patients with AAD.We analyzed 777 patients with AAD. Read More

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http://dx.doi.org/10.1097/MD.0000000000014486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380797PMC
February 2019
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Sepsis patients with complication of hypoglycemia and hypoalbuminemia are an early and easy identification of high mortality risk.

Intern Emerg Med 2019 Feb 7. Epub 2019 Feb 7.

Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.

Either hypoglycemia or hypoalbuminemia alone is an independent condition associated with increased risk of mortality in critical illness. This study evaluates whether the mortality risk increases in septic patients if these conditions are combined. Patients admitted to our hospital from 2008 to 2015 who satisfied the definition of sepsis were targeted (n = 336). Read More

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http://dx.doi.org/10.1007/s11739-019-02034-2DOI Listing
February 2019
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Nephrotic syndrome co-existing with type 1 diabetes in a 12-year-old boy: Case report and literature review.

SAGE Open Med Case Rep 2019 31;7:2050313X19827734. Epub 2019 Jan 31.

Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Occurrence of early nephrotic syndrome in type 1 diabetes mellitus patients is extremely rare. Herein, we report the case of a 12-year-old boy who presented to our pediatric nephrology clinic with generalized edema. He had been diagnosed with type 1 diabetes mellitus at age 9 and had been treated with regular insulin. Read More

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http://dx.doi.org/10.1177/2050313X19827734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357289PMC
January 2019
3 Reads

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome.

BMC Ophthalmol 2019 Feb 6;19(1):44. Epub 2019 Feb 6.

Department of Ophthalmology, Peking University Frist Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: A study was conducted to evaluate the choroidal thickness (CT) and retinal thickness (RT) in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome (NS). We also studied the correlation between the subfoveal choroidal thickness (SFCT) and serum protein concentration.

Methods: This was a cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12886-019-1050-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364472PMC
February 2019
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Methionyl-tRNA synthetase novel mutation causes pulmonary alveolar proteinosis.

Saudi Med J 2019 Feb;40(2):195-198

Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

The  methionyl-tRNA  synthetase  (MARS)  mutation is  a  very  rare  cause  of  congenital  pulmonary  alveolar proteinosis.We report a 6-month-old boy born with symmetrical intrauterine growth retardation presented with unexplained persistent tachypnea and hypoxemia associated with severe failure to thrive, anemia, hypoalbuminemia and hepatomegaly. Detailed pulmonary investigations including computed tomography chest scan, bronchoscopy and bronchoalveolar lavage revealed pulmonary alveolar proteinosis. Read More

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https://smj.org.sa/index.php/smj/article/view/smj.2019.2.239
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http://dx.doi.org/10.15537/smj.2019.2.23908DOI Listing
February 2019
5 Reads

Hypoalbuminemia is an Independent Risk Factor for 30-Day Mortality, Postoperative Complications, Readmission, and Reoperation in the Operative Lower Extremity Orthopedic Trauma Patient.

J Orthop Trauma 2019 Jan 29. Epub 2019 Jan 29.

Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.

Introduction: Malnutrition, as indicated by hypoalbuminemia, is known to have detrimental effects on outcomes following arthroplasty, geriatric hip fractures, and multiple general surgeries. Hypoalbuminemia has been examined in the critically ill but has largely been ignored in the orthopedic trauma literature. We hypothesized that admission albumin levels would correlate with postoperative course in the non-geriatric lower extremity trauma patient. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001448DOI Listing
January 2019
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Nutrition and Inflammation Influence 1-Year Mortality of Surgically Treated Elderly Intertrochanteric Fractures: A Prospective International Multicenter Case Series.

Geriatr Orthop Surg Rehabil 2019 23;10:2151459318816982. Epub 2019 Jan 23.

Missouri Orthopaedic Institute, University of Missouri, Columbia, MO, USA.

Introduction: Hip fracture is a common and devastating event in older adults causing increased dependence, comorbidity, and mortality. Since new surgical techniques have not significantly improved the mortality rate, a better understanding of patient risk factors could improve the treatment algorithm and outcomes. This prospective study aimed to document the 1-year survival rate of patients with intertrochanteric fracture treated surgically in Latin America and to investigate risk factors associated with 1-year mortality. Read More

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http://dx.doi.org/10.1177/2151459318816982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348579PMC
January 2019
1 Read