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    A Prospective Single-Arm Trial of Modified Long Biliopancreatic and Short Alimentary Limbs Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity.
    Obes Surg 2017 Sep 20. Epub 2017 Sep 20.
    Center for Bariatric and Metabolic Surgery, São Domingos Hospital, São Luís, Brazil.
    Background: Type-2 diabetes (T2D) patients with body mass index (BMI) below 35 kg/m(2) carry lower remission rates than severely obese T2D individuals submitted to "standard limb lengths" Roux-en-Y gastric bypass (RYGB). Mild-obese patients appear to have more severe forms of T2D, where the mechanisms of glycemic control after a standard-RYGB may be insufficient. The elongation of the biliopancreatic limb may lead to greater stimulation of the distal intestine, alterations in bile acids and intestinal microbiota, among other mechanisms, leading to better metabolic outcomes. Read More

    J Zoo Wildl Med 2017 Sep;48(3):929-932
    A 10-year-old male castrated red kangaroo (Macropus rufus) presented with mandibular swelling. Examination findings included pitting edema with no dental disease evident on examination or radiographs. The results of blood work were moderate azotemia, hypoalbuminemia, and severely elevated urine protein:creatinine ratio (9. Read More

    Clinical significance of Aspergillus species isolated from respiratory specimens in patients with Mycobacterium avium complex lung disease.
    Eur J Clin Microbiol Infect Dis 2017 Sep 17. Epub 2017 Sep 17.
    Department of Respiratory Medicine, Ohara Memorial Kurashiki Healthcare Foundation, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.
    Chronic pulmonary aspergillosis (CPA) is associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). An Aspergillus-positive respiratory specimen often reflects colonization, and thus the clinical significance of Aspergillus isolation in MAC-LD patients is not well understood. The objective of this study was to investigate the clinical characteristics and outcomes of MAC-LD patients in whom Aspergillus was isolated from respiratory specimens. Read More

    Nephrotic syndrome in infants and children: pathophysiology and management.
    Paediatr Int Child Health 2017 Sep 15:1-11. Epub 2017 Sep 15.
    a Department of Paediatrics , Univeristy of Toronto , Toronto , Canada.
    Nephrotic syndrome is defined by nephrotic-range proteinuria (≥40 mg/m(2)/hour or urine protein/creatinine ratio ≥200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (<25 g/L) and oedema. This review focuses on the classification, epidemiology, pathophysiology, management strategies and prognosis of idiopathic nephrotic syndrome of childhood, and includes a brief overview of the congenital forms. Read More

    Clinical Manifestations of Kawasaki Disease Shock Syndrome.
    Clin Pediatr (Phila) 2017 Sep 1:9922817729483. Epub 2017 Sep 1.
    1 Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
    A case-control study was performed to ascertain clinical features of children who had been diagnosed as Kawasaki disease shock syndrome (KDSS), a severe condition related to Kawasaki disease (KD). Hospitalized patients were selected in Nanjing Children's Hospital. Demographic characteristics, clinical presentation, laboratory data, cardiovascular findings, and therapies were analyzed. Read More

    Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis.
    Cancer 2017 Sep 13. Epub 2017 Sep 13.
    Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
    Background: There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL).

    Methods: Failure-free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Intergroup adult E2496 study and 391 similarly patients ages 17 to 21 years with HL who were treated on the pediatric Children's Oncology Group (COG) AHOD0031 study.

    Results: Comparing AYAs from the COG and E2496 studies, there were no significant differences in extralymphatic disease, anemia, or hypoalbuminemia. Read More

    Development and Validation of a Novel Acute Myeloid Leukemia-Composite Model to Estimate Risks of Mortality.
    JAMA Oncol 2017 Sep 7. Epub 2017 Sep 7.
    Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle.
    Importance: To our knowledge, this multicenter analysis is the first to test and validate (1) the prognostic impact of comorbidities on 1-year mortality after initial therapy of acute myeloid leukemia (AML) and (2) a novel, risk-stratifying composite model incorporating comorbidities, age, and cytogenetic and molecular risks.

    Objective: To accurately estimate risks of mortality by developing and validating a composite model that combines the most significant patient-specific and AML-specific features.

    Design, Setting, And Participants: This is a retrospective cohort study. Read More

    Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children - Short Review.
    Maedica (Buchar) 2017 Jan;12(1):55-58
    "Marie Curie" Emergency Children's Hospital, Bucharest, Romania.
    The idiopathic nephrotic syndrome is a common chronic kidney diseases in children defined by the association of massive proteinuria and hypoalbuminemia in a relapsing/remission course, with histological aspect of minimal changes (also called minimal change disease) in the majority of the cases, but its pathogenesis remains not very well known. Clinical and immunological studies have consistently shown a relationship between atopic diathesis, immunoglobulin E and cytokines involved in immunoglobulin E synthesis and idiopathic nephrotic syndrome. Additional research is necessary to clarify this relationship and to explore the contribution of allergic disease to the development of nephrotic syndrome and to identify potential new strategies of diagnosis and treatment. Read More

    Predictors of emergency colectomy in patients admitted with acute severe ulcerative colitis.
    S Afr J Surg 2017 Sep;55(3):20-26
    Division of Gastroenterology, Department of Medicine, Groote Schuur Hospital and University of Cape Town.
    Background: Acute Severe Ulcerative Colitis (ASUC) is a life-threatening condition which requires urgent and aggressive medical therapy to reduce mortality, morbidity and avoid surgery. To facilitate this process, it is essential to identify patients at high risk of poor outcomes and emergency colectomy. Numerous such risk factors have been described in Western literature, however there is no local data addressing this issue. Read More

    The preoperative albumin level is an independent prognostic factor for optimally debulked epithelial ovarian cancer.
    Arch Gynecol Obstet 2017 Sep 5. Epub 2017 Sep 5.
    Department of Obstetrics and Gynecology, School of Medicine, Başkent University, Ankara, Turkey.
    Purpose: A low albumin level has been reported to be a prognostic factor for various cancers. The aim of this study was to determine the association between preoperative serum albumin level and survival in patients with epithelial ovarian cancer (EOC).

    Methods: Records of 337 patients with EOC that underwent optimal cytoreductive surgery were retrospectively reviewed. Read More

    Ertapenem-associated neurotoxicity in the Spinal Cord Injury (SCI) population: a case series.
    J Spinal Cord Med 2017 Sep 6:1-10. Epub 2017 Sep 6.
    a Department of Pharmacy, Edward Hines, Jr. VA Medical Center , Hines , IL 60141 , USA.
    Context Ertapenem, a broad spectrum carbapenem antibiotic, is used often in Spinal Cord Injury (SCI) patients due to increased risk factors for multi-drug resistant (MDR) infections in this population. Neurotoxicity, specifically seizures, due to ertapenem is a known adverse effect and has been described previously. Other manifestations such as delirium and visual hallucinations have rarely been reported, and no literature, to the best of our knowledge, specifically describes these effects solely in the SCI population. Read More

    Management of Nephrotic Syndrome: A Case Report from Lao PDR.
    Blood Purif 2017 5;44 Suppl 1:31-34. Epub 2017 Sep 5.
    Hemodialysis Center and Division of Nephrology, Mittaphab Hospital, Vientiane, Lao PDR.
    We report the case of a 23-year-old woman with a 2-week history of swelling around the eyes and both legs, and generalized body swelling. She had a history of chronic constipation and poor diet but no fever, recent illnesses, or hematuria. Examination revealed bilateral pedal edema and mild ascites. Read More

    A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report.
    Case Rep Dermatol 2017 May-Aug;9(2):70-78. Epub 2017 Jul 13.
    UNMC Department of Family Medicine, Nebraska Medical Center, Omaha, Nebraska, USA.
    Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. Read More

    [Primary intestinal lymphangiectasia (Waldmann's disease)].
    Rev Med Interne 2017 Aug 31. Epub 2017 Aug 31.
    Service de gastro-entérologie et nutrition, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France.
    Primary intestinal lymphangiectasia (PIL), Waldmann's disease, is a rare disorder of unknown etiology characterized by dilated intestinal lacteals leading to lymph leakage into the small-bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. PIL is generally diagnosed before 3 years of age but may be diagnosed in older patients. The main symptom is bilateral lower limb edema. Read More

    Plasma L-carnitine levels in terminally ill cancer patients receiving only palliative care.
    Ann Palliat Med 2017 Aug 15;6(Suppl 1):S52-S57. Epub 2017 Jun 15.
    Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
    Background: Several studies indicated that plasma L-carnitine (LC) levels are significantly decreased during chemotherapy or chemoradiation and that LC supplementation can improve the fatigue score in some cancer patients. However, the LC levels in end-stage cancer patients treated only with palliative care remained unclear. The present study was performed to examine the plasma LC levels of terminally ill and hospitalized patients. Read More

    Does whey protein supplementation affect blood pressure in hypoalbuminemic peritoneal dialysis patients?
    Ther Clin Risk Manag 2017 14;13:989-997. Epub 2017 Aug 14.
    Department of Internal Medicine E, Galilee Medical Center, Nahariya, Israel.
    Objective: Hypertension and hypoalbuminemia are common risk factors for cardiovascular complications in peritoneal dialysis (PD) patients. Data are limited regarding the effects of whey protein consumption on blood pressure in this population. The aim of the present study was to examine if whey protein supplementation for 12 weeks to hypoalbuminemic PD patients affects their blood pressure. Read More

    Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.
    Sci Rep 2017 Aug 31;7(1):10146. Epub 2017 Aug 31.
    Departments of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan.
    Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). Read More

    Exacerbation of primary intestinal lymphangiectasia during late pregnancy and recovery after delivery: A case report and literature review.
    Medicine (Baltimore) 2017 Sep;96(35):e7928
    Department of Obstetrics, Hangzhou First People's Hospital, Nanjing, Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
    Rationale: Primary intestinal lymphangiectasia (PIL) is a rare disease characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen. Main clinical features include intermittent diarrhea, hypoproteinemia. Scattered case reports suggested that PIL is compatible to pregnancy, but with increased complications. Read More

    Gemcitabine-induced chronic systemic capillary leak syndrome.
    BMJ Case Rep 2017 Aug 30;2017. Epub 2017 Aug 30.
    Division of Hematology and Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
    A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9-86 pg/mL). Read More

    Comparison of hypoalbuminemia-corrected serum calcium using bcp albumin assay to ionized calcium and impact on prescribing in hemodialysis patients
    Clin Nephrol 2017 Aug 30. Epub 2017 Aug 30.
    Background: Albumin-corrected calcium (cCa) is recommended over ionized calcium (iCa) in hemodialysis (HD) patients per the Kidney Disease: Improving Global Outcomes position statements due to cost and feasibility. Two common albumin assays, bromocresol green (BCG) and bromocresol purple (BCP), produce differing results in uremic patients. All previous studies compared iCa to cCa from a BCG assay. Read More

    Hospital-acquired Clostridium difficile infection in Mainland China: A seven-year (2009-2016) retrospective study in a large university hospital.
    Sci Rep 2017 Aug 29;7(1):9645. Epub 2017 Aug 29.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
    Clostridium difficile infection (CDI) is associated with risk for severe disease and high mortality. Little is known about the extent of hospital-acquired CDI in Mainland China. In this study, we aimed to investigate the annual CDI incidence, bacterial genotypes, risk factors for severe CDI and survival over a 7-year period. Read More

    Acute hepatozoonosis in dogs: a case report.
    J Parasit Dis 2017 Sep 27;41(3):747-749. Epub 2017 Jan 27.
    Department of Veterinary Medicine, Veterinary College, Bidar, India.
    Two male dogs aged between 2 and 3 months belonging to German Shepherd and non descript breed were brought to Outpatient unit of Department of Veterinary Medicine, Veterinary College, Bidar with history of anorexia, weakness and going down in body condition since 15 days. Clinical examination revealed fever, enlargement of popliteal and submandibular lymph nodes, pale mucous membranes and cachectic body condition in both the cases. Haemato-biochemical examination revealed anemia, leukocytosis, thrombocytopenia, hypoalbuminemia and elevated levels of blood urea nitrogen, creatinine and alanine amino transferase. Read More

    Biopsy-proven progressive fatty liver disease nine months post mini-gastric bypass surgery: A case study.
    Int J Surg Case Rep 2017 Aug 18;39:168-171. Epub 2017 Aug 18.
    Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Introduction: Mini-gastric bypass (MGB) is a popular bariatric procedure. Its effect on non-alcoholic fatty liver disease (NAFLD), however, has not yet been comprehensively studied.

    Presentation Of Case: A 57 year-old non-alcoholic female with a body mass index of 42. Read More

    [Pulmonary embolism as a presentation of nephrotic syndrome].
    Rev Mal Respir 2017 Sep 25;34(7):765-769. Epub 2017 Aug 25.
    Service de pneumologie, bâtiment I, hôpital de la Croix-Rousse, groupement hospitalier nord, hospices civils de Lyon et université Claude-Bernard Lyon 1, 103, grande-rue de la Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address:
    Background: Nephrotic syndrome (NS) in adults is defined by proteinuria>3g/24h or 50mg/kg/d, hypoproteinemia<60g/24h and hypoalbuminemia<30g/L. The final diagnosis is guided by the histopathology evidence when a renal biopsy is possible. The consequences of NS are multiple: high blood pressure, undernutrition, infections and a hypercoagulable state. Read More

    Hypervolemia, hypoalbuminemia and mitral calcification as markers of cardiovascular risk in peritoneal dialysis patients.
    Rev Port Cardiol 2017 Sep 23;36(9):599-604. Epub 2017 Aug 23.
    Department of Nephrology, Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal.
    Introduction: Mortality in patients with end-stage renal disease is higher than in the general population. This is linked to traditional and non-traditional cardiovascular (CV) risk factors, as well as with risk factors associated with end-stage renal disease itself. The aim of this study is to identify CV risk markers in patients beginning peritoneal dialysis (PD) and their association with CV events and CV mortality. Read More

    Characterization of hypoalbuminemia following temporary abdominal closure.
    J Trauma Acute Care Surg 2017 Oct;83(4):650-656
    From the Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
    Background: The purpose of this study was to characterize associations among serum proteins, negative-pressure wound therapy (NPWT) fluid loss, and primary fascial closure (PFC) following emergent laparotomy and temporary abdominal closure (TAC). We hypothesized that high levels of C-reactive protein (CRP) and NPWT output would be associated with hypoalbuminemia and failure to achieve PFC.

    Methods: We performed a retrospective analysis of 233 patients managed with NPWT TAC. Read More

    Preoperative nutritional risk assessment in patients undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for colorectal carcinomatosis.
    Int J Hyperthermia 2017 Sep 3:1-6. Epub 2017 Sep 3.
    b EMR 3738, Faculté de Médecine Lyon Sud, Université Lyon 1 , Lyon , France.
    Background: Malnutrition is associated with increased postoperative morbidity in colorectal surgery. This study aimed to determine if preoperative nutritional markers could predict postoperative outcomes for patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for peritoneal metastasis (PM) of colorectal origin.

    Methods: All patients who underwent a complete CRS-HIPEC for colorectal PM between January 2009 and December 2014 were evaluated. Read More

    Preoperative prognostic nutritional index is a significant predictor of survival in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy.
    Urol Oncol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
    Background: Patient's nutritional and immunological status have a potentially significant role in survival outcome in patients with malignant tumors. We investigated the prognostic value of preoperative prognostic nutritional index (PNI) in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephrouretectomy (RNU).

    Patients And Methods: A total of 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent RNU were evaluated. Read More

    Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism.
    J Pharm Sci 2017 Aug 17. Epub 2017 Aug 17.
    Department of Environmental and Occupational Health, School of Public Health, IRSPUM, Université de Montréal, Montreal, Quebec, Canada.
    The hepatic clearance (CL) of bisphenol A (BPA) in the isolated perfused rat liver (IPRL) model has been studied for the impact of albumin (ALB) binding and coadministration with naproxen (NAP) in a companion manuscript (Bounakta et al. Xenobiotica. 2017;3:1-13. Read More

    Preoperative hypoalbuminemia is an independent risk factor for increased high-grade morbidity after elective rectal cancer resection.
    Int J Colorectal Dis 2017 Aug 19. Epub 2017 Aug 19.
    Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135, Mannheim, Germany.
    Purpose: This study investigated the association of preoperative hypoalbuminemia and postoperative complications after elective resection for rectal cancer.

    Methods: From September 2009 to December 2014, all patients who underwent elective rectal resection for adenocarcinoma of the rectum were identified using a prospective colorectal cancer database. Hypoalbuminemia was defined as a serum albumin < 35 g/L. Read More

    Hypoalbuminemia is a Predictive Factor for Fistula Formation in Recurrent Cervical Cancer.
    Am J Clin Oncol 2017 Aug 16. Epub 2017 Aug 16.
    *Division of Gynecologic Oncology †Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, TX.
    Objective: Antivascular endothelial growth factor monoclonal antibodies inhibit tumor angiogenesis, consequently impeding the recruitment of new vasculature to existing and new tumor lesions. We sought to evaluate toxicities in women with recurrent cervical cancer after receiving bevacizumab combination chemotherapy.

    Methods: A review was conducted of women with recurrent and metastatic cervical cancer who were treated with salvage chemotherapy with or without bevacizumab between 2005 and 2015. Read More

    Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis.
    J Vet Dent 2017 Sep;34(3):155-160
    1 Department of Clinical Sciences, Cornell University, Ithaca, NY, USA.
    Background: Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a frequently diagnosed condition in adult horses. The underlying etiology is still unknown. Hematologic, biochemical, and endocrine values have not been reported in EOTRH-affected horses. Read More

    Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis.
    J Small Anim Pract 2017 Aug 14. Epub 2017 Aug 14.
    Clinic for Small Animals, Freie Universität Berlin, Oertzenweg 19b, D-14163 Berlin.
    Objective: To report clinical, laboratory and diagnostic imaging features and prognostic factors in dogs with leptospirosis from North-East Germany.

    Materials And Methods: Medical records of dogs diagnosed with leptospirosis from 2006 to 2013 were evaluated retrospectively.

    Results: The study included 99 dogs. Read More

    Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients.
    Am J Med 2017 Aug 9. Epub 2017 Aug 9.
    Institute of Endocrinology, Beilinson Hospital, Petach Tikva, Israel; Sackler School of Medicine, Tel Aviv University, Israel.
    Background: The aim of this study was to investigate the association of albumin levels on admission and change in levels during hospitalization with hospitalization outcomes.

    Methods: Historical prospective data of patients hospitalized between 2011 and 2013 were collected. Levels of albumin were classified as marked hypoalbuminemia (<2. Read More

    Anticoagulant action of low, physiologic, and high albumin levels in whole blood.
    PLoS One 2017 11;12(8):e0182997. Epub 2017 Aug 11.
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria.
    Albumin is the most abundant plasma protein. Critical illness is often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. Read More

    Diagnostic delay in Canadian children with inflammatory bowel disease is more common in Crohn's disease and associated with decreased height.
    Arch Dis Child 2017 Aug 9. Epub 2017 Aug 9.
    Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
    Objectives: To determine time to diagnosis in a paediatric inflammatory bowel disease (IBD) cohort and the relative contribution of the component intervals, and to identify factors associated with diagnostic delay.

    Design: Prospective cohort study SETTING: Single-centre study including children with incident IBD at the Hospital for Sick Children diagnosed between December 2013 and December 2015.

    Interventions: Time to diagnosis and its subintervals were determined and patient, disease and institutional factors were tested for associations. Read More

    Phase I Study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.
    Blood 2017 Aug 9. Epub 2017 Aug 9.
    Laboratory of Molecular Biology, CCR, NCI, NIH, Bethesda, MD, United States.
    Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter, phase I study was conducted to determine the maximum tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (n=55). Read More

    Albumin Use in Patients With Cirrhosis in France: Results of the "ALBU-LIVE" Survey: A Case for Better EASL Guidelines Diffusion and/or Revision.
    J Clin Gastroenterol 2017 Oct;51(9):831-838
    *Service d'Hépato-gastroentérologie, de Nutrition et d'Alcoologie, GHPSO, Creil †Service d'Hépato-gastroentérologie, Centre Hospitalier de Gonesse, Gonesse ‡Service d'Hépato-gastroentérologie, CHRU La Cavale Blanche, Brest §Service d'Hépatologie, CHRU Jean Minjoz, Besançon ∥Service d'Hépato-gastroentérologie, CHU, Caen ¶Service d'Hépatologie, CHRU, Lille #Service d'Hépatologie, CHU Cochin §§Service d'Hépatologie, CHU Pitié-Salpêtrière ‡‡‡Service d'Hépatologie, CHU Saint-Antoine ∥∥∥Service d'Hépato-gastroentérologie, CHU Tenon, Paris **Service d'Hépato-gastroentérologie, Centre Hospitalier, Tourcoing ††Service d'Hépatologie, Centre Hépatobiliaire, Villejuif ‡‡Service d'Hépato-gastroentérologie †††Service de Médecine Interne, CHU, Toulouse ∥∥Service d'Hépatologie, CHU Beaujon, Clichy-la-Garenne ¶¶Service d'Hépato-gastroentérologie, Centre Hospitalier, Montfermeil ##Service d'Hépato-gastroentérologie, Centre Hospitalier, Lagny-sur-Marne ***Service d'Hépatologie, CHU, Reims §§§Service d'Hépato-gastroentérologie, Centre Hospitalier, Saint-Denis ¶¶¶Service d'Hépato-gastroentérologie, CHU, Clermont-Ferrand ###Cabinet médical, Montpellier ****Service d'Hépato-gastroentérologie, CHU, Grenoble ††††Service d'Hépato-gastroentérologie, CHU, Pessac ‡‡‡‡Service d'Hépato-gastroentérologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
    Introduction: The use of human albumin for the management of cirrhosis has increased. Recommendations have been published for therapeutic paracentesis (TP), spontaneous bacterial peritonitis (SBP), and type 1 hepatorenal syndrome (HRS). The goal of this survey was to assess the prescription practices of French hepatogastroenterologists. Read More

    NPHS2 Mutations: A Closer Look to Latin American Countries.
    Biomed Res Int 2017 12;2017:7518789. Epub 2017 Jul 12.
    Center for Molecular Biology and Genetic Engineering (CBMEG), State University of Campinas (UNICAMP), Campinas, SP, Brazil.
    Nephrotic syndrome is one of the most common kidney pathologies in childhood, being characterized by proteinuria, edema, and hypoalbuminemia. In clinical practice, it is divided into two categories based on the response to steroid therapy: steroid-sensitive and steroid resistant. Inherited impairments of proteins located in the glomerular filtration barrier have been identified as important causes of nephrotic syndrome, with one of these being podocin, coded by NPHS2 gene. Read More

    Markers of nutritional status and mortality in older adults: The role of anemia and hypoalbuminemia.
    Geriatr Gerontol Int 2017 Aug 6. Epub 2017 Aug 6.
    Department of Epidemiology, School of Public Health, University of Sao Paulo, São Paulo, SP, Brazil.
    Aim: The aim of the present study was to analyze the impact of anemia and hypoalbuminemia on mortality in a 5-year period.

    Methods: This was longitudinal population-based observational survey part of the Saúde, Bem-Estar e Envelhecimento study (Health, Well-being and Aging), carried out with 1256 older adults from the third wave of the cohort, followed for 5 years, when they were contacted for the fourth wave, in Sao Paulo, Brazil. Anemia was defined when hemoglobin was <12 g/dL for women and <13 g/dL for men, and hypoalbuminemia when serum albumin was <3. Read More

    Multiple small intestinal ulcers associated with protein-losing enteropathy secondary to cholesterol crystal embolism:a case report.
    Nihon Shokakibyo Gakkai Zasshi 2017 ;114(8):1436-1445
    Department of Histopathology and Cytology, Kyoto Second Red Cross Hospital.
    A 78-year-old man with hypertension, nephrosclerosis, and angina pectoris visited his family doctor with a history of fatigue and leg edema. He had a history of percutaneous coronary intervention 5 years prior, and was taking low-dose aspirin. Blood tests revealed hypoalbuminemia, gastrointestinal (99m)Tc-HSA scintigraphy was positive, and alpha-1 antitrypsin clearance was high;therefore, the hypoalbuminemia was thought to be secondary to a protein-losing enteropathy. Read More

    Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis.
    Front Med 2017 Sep 3;11(3):333-339. Epub 2017 Aug 3.
    Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
    Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Read More

    Lower serum P1NP/βCTX ratio and hypoalbuminemia are independently associated with osteoporotic nonvertebral fractures in older adults.
    Clin Interv Aging 2017 19;12:1131-1140. Epub 2017 Jul 19.
    Department of Orthopaedic Surgery, The Canberra Hospital, ACT Health, Canberra, Australia.
    Purpose: To estimate the discriminative value of serum P1NP/βCTX ratio and albumin levels in hospitalized orthogeriatric patients with and without nonvertebral fractures.

    Methods: In 1,239 orthogeriatric patients (mean age 78.1±9. Read More

    Protein-losing Gastroenteropathy Related to Mixed Connective Tissue Disease: A Case Report of a Successful Outcome and Literature Review.
    Intern Med 2017 1;56(15):2057-2062. Epub 2017 Aug 1.
    Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Japan.
    We herein report the case of a 44-year-old woman who developed protein-losing gastroenteropathy (PLGE) with hypoalbuminemia as the first manifestation of mixed connective tissue disease (MCTD). Albumin leakage from the stomach and intestinal tract was demonstrated by (99m)Tc-labeled human serum albumin scintigraphy. The patient's response to prednisolone therapy was insufficient; therefore, additional cyclosporin A (CsA) treatment was administered, and clinical remission was achieved. Read More

    Folate deficiency in north Indian children undergoing maintenance chemotherapy for acute lymphoblastic leukemia-Implications and outcome.
    Pediatr Blood Cancer 2017 Aug 2. Epub 2017 Aug 2.
    Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Background: Treatment-related toxicity and mortality are not uncommon during maintenance chemotherapy for childhood acute lymphoblastic leukemia (ALL), especially in the low- and middle-income countries (LMIC). Undernutrition and micronutrient deficiencies are commonly seen in children from LMICs undergoing treatment for ALL. The present study examines the prevalence and clinical implications of folate deficiency in north Indian children with ALL during the maintenance phase of treatment in view of prolonged antifolate treatment and high population prevalence of folate deficiency. Read More

    Performance of Disease-Specific Scoring Models in Intensive Care Patients with Severe Liver Diseases.
    J Clin Diagn Res 2017 Jun 1;11(6):OC12-OC16. Epub 2017 Jun 1.
    Lecturer, Department of Biostatistics, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
    Introduction: Egypt has the highest prevalence of Hepatitis C Virus (HCV) in the world, estimated nationally at 14.7%. HCV treatment consumes 20% ($80 million) of Egypt's annual health budget. Read More

    [Efficacy of PVD regimen combined with IMRT for early-stage extranodal nasal NK/T-cell lymphoma].
    Zhonghua Yi Xue Za Zhi 2017 Jul;97(26):2047-2049
    Department of Lymphoma, Cancer Hospital of Guizhou Medical, Guiyang 550001, China.
    Objective: To evaluate the efficacy of PVD chemo-regimen (Pegaspargase, vincristine and dexamethasone) combined with intensity-modulated radiotherapy (IMRT) for patients with early-stage extranodal nasal NK/T-cell lymphoma (ENKL). Methods: Clinical data of 52 patients with early-stage ENKL were collected during May 2010 and June 2015 in Department of Lymphoma, Cancer Hospital of Guizhou Medical University, and these patients firstly received a concurrent chemoradiotherapy of two-cycle of PVD and IMRT (gross tumor volume primary: 12.6-59. Read More

    European Veterinary Renal Pathology Service: A Survey Over a 7-Year Period (2008-2015).
    J Vet Intern Med 2017 Sep 1;31(5):1459-1468. Epub 2017 Aug 1.
    Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
    Background: The European Veterinary Renal Pathology Service (EVRPS) is the first Web-based registry for canine renal biopsy specimens in Europe.

    Hypothesis/objectives: The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.

    Animals: Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Read More

    Diagnostic Challenges of Hemophagocytic Lymphohistiocytosis.
    Clin Lymphoma Myeloma Leuk 2017 Jul;17S:S105-S110
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO. Electronic address:
    Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by excessive activation of the immune system, resulting in overproduction of inflammatory cytokines. Patients usually present with high fever, cytopenias, hyperferritinemia, and hepatosplenomegaly, and their disease process ranges from mild to fatal multiorgan failure. HLH is a heterogeneous group of disorders that can be triggered by infections, neoplasms, or autoimmune diseases. Read More

    Acute hemorrhagic rectal ulcer (AHRU) syndrome: comparison with non-AHRU lower gastrointestinal bleeding.
    J Dig Dis 2017 Jul 28. Epub 2017 Jul 28.
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, 170, Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, 10380, Korea.
    Aim: Acute hemorrhagic rectal ulcer (AHRU) syndrome can cause massive, life-threatening rectal bleeding. Sigmoidoscopic hemostasis with enema can often be performed to effectively control rectal bleeding.

    Methods: The medical records of AHRU patients were retrospectively reviewed. Read More

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