759 results match your criteria Hyperviscosity Syndrome


Plasma viscosity: Evaluation of a new measuring method using microfluidic chip technology (microVisc™) for clinical use and determination of a new reference range.

Ann Clin Biochem 2020 May 27;57(3):249-252. Epub 2020 Apr 27.

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Background: Plasma viscosity is an important biomarker both in diagnostics and treatment monitoring of plasma cell dyscrasias and other disorders with hyperviscosity syndrome as a clinical manifestation. Here, we investigate the performance of a new microfluidic-based viscometer for clinical use, establish a new reference range to be used with this instrument and determine the importance of sampling temperature.

Methods: The microVisc™ viscometer was evaluated for within-run and between-run imprecision and bias using standardized reference material (Paragon controls) and Seronorm™ control material. Read More

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http://dx.doi.org/10.1177/0004563220920903DOI Listing

A molecular communications system for live detection of hyperviscosity syndrome.

IEEE Trans Nanobioscience 2020 Apr 1. Epub 2020 Apr 1.

The hyperviscosity syndrome consists of an excessive viscosity of the blood. It has to be timely detected, since it significantly increases the risk of many cardiovascular diseases. It can manifest essentially in two different ways, depending on the capability of the cardiocirculatory system to compensate the increased resistance experienced by the blood in vessels. Read More

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http://dx.doi.org/10.1109/TNB.2020.2984880DOI Listing

[Bilateral occlusion of retinal vessels in Waldenstrom's disease (a case study)].

Vestn Oftalmol 2020 ;136(1):90-96

Helmholtz National Medical Research Center of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.

The article describes a clinical case of bilateral occlusion of retinal vessels in a patient with Waldenstrom's disease - a rare lymphoplasmocytic tumor of the bone marrow characterized by a complex of syndromes, among which the syndrome of blood hyperviscosity dominates. Comprehensive clinical, instrumental and laboratory examinations revealed that besides the syndrome of blood hyperviscosity the patient also had loci of cerebral ischemia (according to magnetic resonance imaging), ocular hypoperfusion with severe deficiency of retinal and choroidal blood flow (according to Doppler methods) indicating the presence of ocular ischemic syndrome. Since bilateral occlusion of retinal vessels without concomitant vascular and/or systemic pathology is rare, patients with such diagnosis should be referred to a hematologist. Read More

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http://dx.doi.org/10.17116/oftalma202013601190DOI Listing

A Case of a Lymphoplasmacytic Lymphoma with Trisomy 12 in the Lymphoid Population and Deletion 13q in the Unstimulated Cell Culture.

J Assoc Genet Technol 2020 ;46(1):14-19

The International Circle of Genetic Studies, Los Angeles, CA.

Objectives: Lymphoplasmacytic lymphoma (LPL, previously termed lymphoplasmacytoid lymphoma) is an uncommon mature B-cell lymphoma usually involving the bone marrow and less commonly the spleen and/or lymph nodes. The majority of patients with LPL have a circulating monoclonal immunoglobulin M (IgM) that can lead to a hyperviscosity syndrome known as Waldenström macroglobulinemia (WM). Although LPL appears to be a sporadic disease in the majority of cases, a familial predisposition is present in some cases. Read More

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January 2020

Lessons learned from immunoadsorption for hyperviscosity in IgM multiple myeloma-A case report.

J Clin Apher 2020 Mar 6. Epub 2020 Mar 6.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.

We report the case of a 63-year-old Caucasian woman with multiple relapsed IgM multiple myeloma (MM) and elevated free kappa light chains (fκLC). Due to hyperviscosity syndrome with visual impairment, regular plasma exchanges were performed. As part of her 11th line of therapy, an experimental protocol consisting of pembrolizumab, pomalidomide, and dexamethasone was initiated. Read More

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http://dx.doi.org/10.1002/jca.21775DOI Listing

Rare Presentation of Bilateral Central Retinal Vein Occlusion and Leukemic Retinopathy in a Young Adult Diagnosed with T-cell Acute Lymphoblastic Leukemia.

Cureus 2020 Jan 15;12(1):e6666. Epub 2020 Jan 15.

Emergency Medicine, Thomas Jefferson University, Philadelphia, USA.

Simultaneous bilateral central retinal vein occlusion (CRVO) is a rare presentation that warrants consideration of an underlying hyperviscosity state. Increased serum viscosity can lead to the hematologic emergency of leukostasis with resultant vascular obstruction and hypoxic tissue damage. The following case demonstrates the first case of bilateral CRVO in a young adult secondary to acute lymphoblastic leukemia (ALL). Read More

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http://dx.doi.org/10.7759/cureus.6666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021241PMC
January 2020

Hyperviscosity-related splenic infarction, gastrointestinal ischaemia-reperfusion injury and transient dysarthria in a patient with distributive shock due to idiopathic systemic capillary leak syndrome (Clarkson's syndrome).

BMJ Case Rep 2020 Jan 23;13(1). Epub 2020 Jan 23.

Department of Internal Medicine, Spaarne Gasthuis Medical Centre, Hoofddorp, The Netherlands

Clarkson's syndrome, also known as idiopathic systemic capillary leak syndrome, is characterised by vascular hyperpermeability resulting in intravascular hypovolaemia and shock. A clinician should consider the diagnosis if other causes of shock, for example, sepsis and anaphylaxis, are ruled out and concomitant hyperviscosity is not caused by a myeloproliferative disease. Here, we describe a patient presenting with severe plasma leakage and assumable blood hyperviscosity leading to splenic infarction, gastrointestinal ischaemia-reperfusion syndrome and transient dysarthria. Read More

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http://dx.doi.org/10.1136/bcr-2019-232500DOI Listing
January 2020

Waldenstrom's macroglobulinemia in the era of immunotherapy.

Leuk Lymphoma 2020 Jun 21;61(6):1292-1304. Epub 2020 Jan 21.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Waldenstrom macroglobulinemia (WM) is a lymphoplasmacytic lymphoma that presents with symptomatic anemia, thrombocytopenia, constitutional symptoms, extramedullary disease and rarely hyperviscosity syndrome. The presence of both IgM monoclonal protein and ≥10% monoclonal lymphoplasmacytic cells is required for the diagnosis. MyD88 is present in 67-90% of patients but is not pathognomonic for WM. Read More

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http://dx.doi.org/10.1080/10428194.2020.1711901DOI Listing

Clinical, Laboratory, and Bone Marrow Findings of 31 Patients With Waldenström Macroglobulinemia.

Ann Lab Med 2020 May;40(3):193-200

Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

Background: Waldenström macroglobulinemia (WM) is a subset of lymphoplasmacytic lymphoma (LPL) with bone marrow (BM) involvement and an IgM monoclonal gammopathy of any level. We aimed to identify the clinical, laboratory, and BM findings of patients with WM and to evaluate the usefulness of CD154 for the diagnosis and prognosis of WM.

Methods: We reviewed the medical records and BM studies and/or flow cytometric immunotyping of 31 patients with untreated WM. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933056PMC

Management of intraoral bleeding in patients with Waldenström macroglobulinemia: A protocol proposal.

Spec Care Dentist 2020 Jan 2;40(1):134-141. Epub 2019 Dec 2.

Department of Maxillofacial Surgery, School of Dentistry, Aichi-gakuin University, Nagoya, Japan.

Aim: Waldenström macroglobulinemia is a type of non-Hodgkin lymphoma with poor prognosis observed in patients with hyperviscosity syndrome because of its tendency for fatal symptoms. This study investigated the risk of intraoral bleeding in patients with Waldenström macroglobulinemia based on hyperviscosity syndrome stage and oral health status, and described potential strategies for managing intraoral bleeding.

Methods And Results: Between April 2012 and March 2017, seven patients with Waldenström macroglobulinemia underwent dental procedures or tooth extraction. Read More

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http://dx.doi.org/10.1111/scd.12440DOI Listing
January 2020

Antihyperglycaemic, haemorheological and antioxidant activities of Lychnis chalcedonica L. extract in a streptozotocin-induced rat model of diabetes mellitus.

J Complement Integr Med 2019 Nov 9. Epub 2019 Nov 9.

Department of Anesthesiology, Critical Care, and Pain Medicine, Steward St. Elizabeth's Medical Center/Tufts University School of Medicine, Boston, MA,USA.

Background New therapeutic strategies, such as the use of agents to correct rheological disorders, are needed for the prevention and treatment of angiopathy in diabetic patients. The aim of this work was to study the antihyperglycaemic, haemorheologic and antioxidant activities of an extract from the flowering plant Lychnis chalcedonica L. (ELC) and 20-hydroxyecdysone using the streptozotocin-induced model of diabetic rats. Read More

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http://dx.doi.org/10.1515/jcim-2017-0028DOI Listing
November 2019

A Puzzling Case of Hyperviscosity Syndrome.

J Appl Lab Med 2020 Jan;5(1):209-213

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1373/jalm.2019.029157DOI Listing
January 2020
1 Read

Hypercholesterolemia Due to Lipoprotein X: Case Report and Thematic Review.

Clin Med Insights Endocrinol Diabetes 2019 29;12:1179551419878687. Epub 2019 Sep 29.

Endocrinology Section, Fundación Santa Fe de Bogotá, Bogotá, Colombia.

The liver is a key organ in lipid and lipoprotein metabolism, hence hepatic diseases often manifest as lipid disturbances. Cholestatic liver diseases are frequently associated with an important increase in total cholesterol at the expense of lipoprotein X (LpX), an abnormal lipoprotein isolated and characterized in the 1960s to 1970s in patients with obstructive jaundice. Lipoprotein X is rich in phospholipids, albumin, and free cholesterol, has a density similar to low-density lipoprotein (LDL), and a size similar to very low-density lipoprotein (VLDL), which has hampered its detection through routine laboratory tests. Read More

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http://dx.doi.org/10.1177/1179551419878687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769215PMC
September 2019
2 Reads

Waldenström Macroglobulinemia and Cerebral Venous Thrombosis: From Diagnosis to Complication.

Case Rep Med 2019 14;2019:9581605. Epub 2019 Jul 14.

Department of Internal Medicine, Centro Hospitalar da Cova da Beira E.P.E., Covilhã 6200-251, Portugal.

Waldenström macroglobulinemia (WM) is a type of non-Hodgkin lymphoma in which cancer cells produce large amounts of an abnormal protein that can cause hyperviscosity syndrome (HVS). A 43-year-old woman with WM, who developed seizures, had a head computed tomography scan that showed signs of cerebral venous thrombosis (CVT). Nevertheless, the value of immunoglobulin M was lower than 50 g/L, and evaluation of serum viscosity was not performed. Read More

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https://www.hindawi.com/journals/crim/2019/9581605/
Publisher Site
http://dx.doi.org/10.1155/2019/9581605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664570PMC
July 2019
5 Reads

Management of severe hypertriglyceridemia due to lipoprotein lipase deficiency in children

Endocrinol Diabetes Metab Case Rep 2019 Jul 26;2019(1):1-5. Epub 2019 Jul 26.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong

Summary: Severe hypertriglyceridemia is an endocrine emergency and is associated with acute pancreatitis and hyperviscosity syndrome. We describe an infant with lipoprotein lipase deficiency with severe hypertriglyceridemia who presented with acute pancreatitis. She was managed acutely with fasting and intravenous insulin infusion, followed by low-fat diet with no pharmacological agent. Read More

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http://dx.doi.org/10.1530/EDM-19-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685095PMC
July 2019
4 Reads

High Hemoglobin Level As a Limiting Factor for Extracorporeal Membrane Oxygenation.

ASAIO J 2019 Nov/Dec;65(8):e97-e99

From the Department of Intensive Care of CHU Brugmann, Brussels, Belgium.

We report the case of a 47 year old male who developed acute respiratory distress syndrome after bariatric surgery, requiring a venovenous extracorporeal membrane oxygenation. An inadequate extracorporeal membrane oxygenation output flow was observed, possibly because of severe polycythemia and hyperviscosity. Management with acute normovolemic hemodilution corrected both the biologic and hemodynamic parameters. Read More

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http://dx.doi.org/10.1097/MAT.0000000000000959DOI Listing
July 2019
4 Reads

Contrast Nephropathy Associated with Percutaneous Coronary Angiography and Intervention.

Cardiol Clin 2019 Aug 9;37(3):287-296. Epub 2019 May 9.

Division of Nephrology, Henry Ford Hospital, CFP-506, 2799 West Grand Boulevard, Detroit, MI 48202, USA.

Contrast nephropathy (CN) is acute kidney injury (AKI) that occurs within 24 to 72 hours of iodinated contrast medium (ICM) administration. Mechanisms of CN include hyperviscosity, free radical formation, and renal medullary oxygen supply/demand mismatch. Although risk factors for CN have been identified, it remains uncertain whether ICM causes or is simply associated with AKI. Read More

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http://dx.doi.org/10.1016/j.ccl.2019.04.004DOI Listing
August 2019
1 Read

[Evaluation of blood rheology by patients with acute ischemic stroke with Mexidol administration].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(3. Vyp. 2):76-82

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

To study rheological properties of blood in patients with acute ischemic stroke treated with mexidol.

Material And Methods: Sixty patients with acute stroke, including 32 patients who received mexidol (500 mg/IV/20 days) and 28 people who received magnesium sulfate (2000 mg/IV/20 days) were examined. The control group included 20 people without a cardiovascular pathology. Read More

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http://dx.doi.org/10.17116/jnevro201911903276DOI Listing
August 2019
16 Reads

[Hyperviscosity syndrome].

J Fr Ophtalmol 2019 09 25;42(7):e301-e303. Epub 2019 May 25.

Service ophtalmologie, hôpital Avicenne, 125, rue de Stalingrad, 93000 Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.jfo.2019.01.011DOI Listing
September 2019
5 Reads

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats.

Molecules 2019 May 3;24(9). Epub 2019 May 3.

Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia.

c-Jun N-terminal kinase (JNK) is activated by various brain insults and is implicated in neuronal injury triggered by reperfusion-induced oxidative stress. Some JNK inhibitors demonstrated neuroprotective potential in various models, including cerebral ischemia/reperfusion injury. The objective of the present work was to study the neuroprotective activity of a new specific JNK inhibitor, IQ-1S (11-indeno[1,2-]quinoxalin-11-one oxime sodium salt), in the model of global cerebral ischemia (GCI) in rats compared with citicoline (cytidine-5'-diphosphocholine), a drug approved for the treatment of acute ischemic stroke and to search for pleiotropic mechanisms of neuroprotective effects of IQ-1S. Read More

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http://dx.doi.org/10.3390/molecules24091722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539151PMC
May 2019
11 Reads

Diagnosis and Management of Oncologic Emergencies.

West J Emerg Med 2019 Mar 14;20(2):316-322. Epub 2019 Feb 14.

Virginia Tech Carilion School of Medicine, Department of Emergency Medicine, Roanoke, Virginia.

Oncologic emergencies may be seen in any emergency department and will become more frequent as our population ages and more patients receive chemotherapy. Life-saving interventions are available for certain oncologic emergencies if the diagnosis is made in a timely fashion. In this article we will cover neutropenic fever, tumor lysis syndrome, hypercalcemia of malignancy, and hyperviscosity syndrome. Read More

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https://escholarship.org/uc/item/3x84z2bq
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http://dx.doi.org/10.5811/westjem.2018.12.37335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404710PMC
March 2019
33 Reads

Dexamethasone implant for immunogammopathy maculopathy associated with IgA multiple myeloma.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841418820441. Epub 2019 Jan 8.

Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.

Background: We describe a case where hyperviscosity retinopathy and immunogammopathy maculopathy were the presenting features of IgA multiple myeloma and report the response of maculopathy to intravitreal injection of dexamethasone implants.

Case Presentation: A 56-year-old man presented at the Department of Ophthalmology with the chief complain of reduced vision for the past 10 days in both eyes. Ophthalmic examination revealed central retinal vein occlusion resembling signs with severe macular edema in both eyes with prominent serous macular detachment. Read More

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http://dx.doi.org/10.1177/2515841418820441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329023PMC
January 2019
8 Reads

Cryoglobulinemia as a Possible Primer for TRALI: Report of a Case.

Lab Med 2019 Jul;50(3):313-319

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.

Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Read More

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http://dx.doi.org/10.1093/labmed/lmy073DOI Listing
July 2019
9 Reads

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000197DOI Listing
November 2018
17 Reads

Vasoproliferative retinopathy secondary to Waldenström's disease.

Arch Soc Esp Oftalmol 2019 Feb 11;94(2):85-89. Epub 2018 Oct 11.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

A 66 year-old patient, monitored for diabetic retinopathy refractory to multiple treatment methods despite a good metabolic control, referred to progressive weight loss. For this reason, a systemic study was performed, detecting anaemia, elevation of the erythrocyte sedimentation rate, and hyperproteinaemia due to elevated serum levels of monoclonal IgM. Subsequently, by performing a bone marrow biopsy and genetic study, the diagnosis of Waldenström macroglobulinaemia was made. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.09.006DOI Listing
February 2019
12 Reads

Hyperviscosity syndrome in splenic marginal zone lymphoma.

Blood 2018 10;132(15):1627

Keck School of Medicine of the University of Southern California.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-07
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http://dx.doi.org/10.1182/blood-2018-07-863787DOI Listing
October 2018
11 Reads

SEVERE HYPERTRIGLYCERIDEMIA IN PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE.

AACE Clin Case Rep 2019 Mar-Apr;5(2):e99-e103. Epub 2018 Oct 5.

Objective: Severe gestational hypertriglyceridemia is a rare disease, and there are no published guidelines to assist the clinician in management. However, due to the elevations in lipids that occur during pregnancy, this condition is encountered in clinical practice and presents a therapeutic dilemma. We report the successful management and treatment of a patient with severe gestational hypertriglyceridemia and conducted a review of the literature regarding treatment modalities. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873862PMC
October 2018

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.

J Ophthalmol 2018 9;2018:8629429. Epub 2018 Sep 9.

Department of Ophthalmology, Taichung Veterans General Hospital, Taichung 407, Taiwan.

Purpose: To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients.

Methods: From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2013, a total of 22919 subjects with RVO were enrolled in the RVO group, and 114595 propensity score (PS)-matched non-RVOs were enrolled in the comparison group. PS matching was based on age, gender, obesity, diabetes, hypertension, hyperlipidemia, coronary artery disease, atrial fibrillation, hyperviscosity syndrome, Charlson comorbidity index, glaucoma, and the use of antithrombotic drugs. Read More

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http://dx.doi.org/10.1155/2018/8629429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151214PMC
September 2018
15 Reads

Oncologic Emergencies: Recognition and Initial Management.

Am Fam Physician 2018 06;97(11):741-748

Novant health Family Medicine Residency, Charlotte, NC, USA.

Most oncologic emergencies can be classified as metabolic, hematologic, structural, or treatment related. Tumor lysis syndrome is a metabolic emergency that presents as severe electrolyte abnormalities. Stabilization is focused on vigorous rehydration, maintaining urine output, and lowering uric acid levels. Read More

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June 2018
20 Reads

Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia.

Hematol Oncol 2019 Apr 7;37(2):117-128. Epub 2018 Sep 7.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Read More

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http://dx.doi.org/10.1002/hon.2539DOI Listing
April 2019
35 Reads

Initial Evaluation of the Patient with Waldenström Macroglobulinemia.

Hematol Oncol Clin North Am 2018 10 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.05.008DOI Listing
October 2018
14 Reads

Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia.

J Clin Apher 2018 Oct 6;33(5):611-615. Epub 2018 Sep 6.

Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.

Background: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation.

Objectives: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP. Read More

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http://dx.doi.org/10.1002/jca.21655DOI Listing
October 2018
25 Reads

Acute hyperviscosity: syndromes and management.

Authors:
Morie A Gertz

Blood 2018 09 13;132(13):1379-1385. Epub 2018 Aug 13.

Mayo Clinic, Rochester, MN.

Plasma hyperviscosity is a rare complication of both monoclonal and polyclonal disorders associated with elevation of immunoglobulins. Asymptomatic patients with an elevation in the serum viscosity do not require plasma exchange, and the majority will have other indications for therapeutic intervention. For patients with hemorrhagic or central nervous system manifestations, plasma exchange is the therapy of choice and is relatively safe. Read More

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http://dx.doi.org/10.1182/blood-2018-06-846816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161773PMC
September 2018
5 Reads

Rapid Fire: Acute Blast Crisis/Hyperviscosity Syndrome.

Emerg Med Clin North Am 2018 Aug 11;36(3):603-608. Epub 2018 Jun 11.

Department of Emergency Medicine, Wexner Medical Center at The Ohio State University, 760 Prior Hall, 376 West 10th Avenue, Columbus, OH 43210, USA.

Emergency providers are likely to encounter patients with acute and chronic leukemias. In some cases, the first presentation to the emergency department may be for symptoms related to blast crisis and leukostasis. Making a timely diagnosis and consulting a hematologist can be life saving. Read More

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http://dx.doi.org/10.1016/j.emc.2018.04.005DOI Listing
August 2018
14 Reads

Idelalisib in a patient with refractory Waldenström's macroglobulinemia complicated by anuric renal failure: a case report.

J Med Case Rep 2018 Jun 12;12(1):164. Epub 2018 Jun 12.

Hematology Department, University Hospital of Nancy, 1, allée du Morvan, 54511, Vandoeuvre Cedex, France.

Background: Waldenström's macroglobulinemia is a rare B-cell lymphoma. The gold standard treatment for Waldenström's macroglobulinemia is an anti-CD20 antibody (rituximab) in combination with alkylating agents and dexamethasone. Treatment targeting the B-cell receptor such as ibrutinib (but not idelalisib) is currently approved for treatment of patients with relapsed or refractory Waldenström's macroglobulinemia. Read More

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http://dx.doi.org/10.1186/s13256-018-1694-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996512PMC
June 2018
12 Reads

Use of intravenous iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension.

Int J Cardiol 2018 Sep 19;267:79-83. Epub 2018 May 19.

Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College School of Medicine, London, UK. Electronic address:

Background: Secondary erythrocytosis is common in patients with cyanosis secondary to congenital heart disease (CHD) and/or pulmonary hypertension (PH). This compensatory mechanism aims at increasing oxygen delivery to the tissues, but it requires adequate iron stores. Optimal methods of iron supplementation in this setting remain controversial, with fears of excessive erythropoiesis and hyperviscosity symptoms. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.05.062DOI Listing
September 2018
43 Reads

MR imaging findings in some rare neurological complications of paediatric cancer.

Insights Imaging 2018 Jun 15;9(3):313-324. Epub 2018 May 15.

Department of Radiology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Read More

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http://dx.doi.org/10.1007/s13244-018-0628-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991004PMC
June 2018
30 Reads

Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats.

Microvasc Res 2018 09 6;119:91-97. Epub 2018 May 6.

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Background: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms.

Objective: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied.

Methods: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i. Read More

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http://dx.doi.org/10.1016/j.mvr.2018.04.005DOI Listing
September 2018
35 Reads

Increased plasma viscosity in plasma cell dyscrasia and whole blood viscosity in polycythemia vera.

Clin Hemorheol Microcirc 2018 ;70(1):59-67

Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background: Although hyperviscosity syndrome in plasma cell dyscrasia (PCD) and thrombosis in myeloproliferative neoplasm (MPN) are major causes of morbidity and mortality, blood viscosity measurements are often underutilized.

Objective: This study aimed to characterize whether whole blood viscosity (WBV) or plasma viscosity (PV) could be predictive of hyperviscosity syndrome in PCD and could be elevated in subgroups of MPN.

Methods: A total of 75 patients with hematologic diseases: PCD (n = 26), MPN (n = 25) including polycythemia vera (P. Read More

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http://dx.doi.org/10.3233/CH-170304DOI Listing
November 2018
22 Reads

Blood Is Thicker: Hyperviscosity Syndrome.

Am J Med 2018 08 22;131(8):916-917. Epub 2018 Mar 22.

Department of Medicine, University of California, San Francisco; Department of Medicine, Medical Service, VA Medical Center, San Francisco, Calif.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183021
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http://dx.doi.org/10.1016/j.amjmed.2018.02.022DOI Listing
August 2018
21 Reads

Therapeutic plasma exchange for hyperviscosity syndrome secondary to high rheumatoid factor.

Transfus Apher Sci 2018 Apr 15;57(2):225-227. Epub 2018 Feb 15.

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, United States.

Hyperviscosity syndrome (HVS) is most commonly associated with Waldenstrom's macroglobulinemia, where it may be life-threatening. HVS may also occur in autoimmune diseases; data pertaining to efficacy of therapeutic plasma exchange (TPE) in HVS arising in non-malignant gammopathy are limited. We report a case of 71-year-old female with erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal <35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis and plasma viscosity (8. Read More

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http://dx.doi.org/10.1016/j.transci.2018.02.004DOI Listing
April 2018
27 Reads

The use of emergency apheresis in the management of plasma cell disorders.

Transfus Apher Sci 2018 Feb 20;57(1):35-39. Epub 2018 Feb 20.

Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Division of Hematology, Therapeutic Apheresis Unit and Blood Bank, Istanbul, Turkey. Electronic address:

Hyperviscosity syndrome (HVS) develops most commonly in Waldenström's macroglobulinemia (WM) and multiple myeloma (MM). Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The most commonly used replacement fluid is 4%-5% human albumin in physiologic saline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14730502183004
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http://dx.doi.org/10.1016/j.transci.2018.02.014DOI Listing
February 2018
33 Reads

Hyperviscosity syndrome.

Intensive Care Med 2018 07 23;44(7):1151-1152. Epub 2018 Feb 23.

Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, 75012, France.

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http://dx.doi.org/10.1007/s00134-018-5087-yDOI Listing
July 2018
10 Reads

Blood rheology of angina pectoris patients with myocardial injury after ischemia reperfusion and its effect on thromboxane B levels.

Exp Ther Med 2018 Jan 6;15(1):769-772. Epub 2017 Nov 6.

Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B (TXB) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure. Read More

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http://dx.doi.org/10.3892/etm.2017.5449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772472PMC
January 2018
13 Reads

Intensely Pruritic Papules and Plaques in Waldenstrom's Macroglobulinemia.

Ann Dermatol 2018 Feb 26;30(1):87-90. Epub 2017 Dec 26.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Waldenstrom's macroglobulinemia (WM) is lymphoplasmacytoid malignancy that affects B lymphocytes. Cutaneous involvement of WM is rare, but various cutaneous manifestations have been reported. These findings are due to various pathological processes including direct invasion of tumor cells into the skin, deposition of paraproteins, hyperviscosity syndrome, and cryoglobulinemia. Read More

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http://dx.doi.org/10.5021/ad.2018.30.1.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762484PMC
February 2018
20 Reads

A clinical picture of pulmonary embolism revealing light-chain myeloma.

Clin Case Rep 2017 12 2;5(12):2044-2046. Epub 2017 Nov 2.

Department of Clinical Biochemistry and Toxicology Faculty of Medicine and Pharmacy Mohammed V Military Teaching Hospital Mohammed V University Rabat Morocco.

We are highlighting on the particularity of a clinical picture of pulmonary embolism revealing light-chain myeloma in a 56-year-old male patient. Myeloma remains a rare affection. Even though its revelation through pulmonary embolism remains rare, it can be explained by hyperviscosity syndrome accompanying it. Read More

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http://dx.doi.org/10.1002/ccr3.1234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715419PMC
December 2017
47 Reads

A Case of Advanced Glaucoma with Increased Episcleral Venous Pressure in a 17-Year-Old with Eisenmenger Syndrome.

Case Rep Ophthalmol Med 2017 23;2017:5808047. Epub 2017 Oct 23.

Mater Dei Hospital, Msida, Malta.

Eisenmenger syndrome refers to reversal of shunt and central cyanosis due to pulmonary hypertension induced by congenital heart disease with a large systemic-to-pulmonary shunt. We report a case of a 17-year-old man with Eisenmenger syndrome who presented with gradual deterioration in visual acuity and was diagnosed with advanced secondary open angle glaucoma. There have been reports of patients suffering from thrombosis due to hyperviscosity associated with this syndrome; however, to our knowledge, the association of secondary open angle glaucoma with Eisenmenger syndrome has not yet been documented. Read More

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http://dx.doi.org/10.1155/2017/5808047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672606PMC
October 2017
25 Reads

Multiple Myeloma Presenting as Acute Renal Failure in the Absence of Other Characteristic Features.

Cureus 2017 Sep 20;9(9):e1703. Epub 2017 Sep 20.

Hematology and Oncology, University of Arizona Cancer Center.

This case report describes a 54-year-old, asymptomatic man who presented with hyperkalemia on routine lab testing who was later found to have acute renal failure, unresponsive to fluid resuscitation, with minimal improvement after hemodialysis. After a comprehensive evaluation ruled out common causes of acute renal failure, the patient underwent testing with a bone survey, urine protein electrophoresis (UPEP), serum protein electrophoresis (SPEP), and immunoelectrophoresis for suspected plasma cell dyscrasia and received plasmapheresis for hyperviscosity syndrome and nephrotoxicity, which resulted in improved renal function. Lab results showed monoclonal gammopathy, elevated serum free light chains, and Bence Jones protein in the urine with a follow-up bone marrow biopsy indicating plasma cell dyscrasia. Read More

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http://dx.doi.org/10.7759/cureus.1703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690288PMC
September 2017
22 Reads

[Expert consensus for the diagnosis and treatment of patients with renal impairment of multiple myeloma].

Authors:

Zhonghua Nei Ke Za Zhi 2017 Nov;56(11):871-875

Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2017.11.022DOI Listing
November 2017
16 Reads