789 results match your criteria Hyperviscosity Syndrome


Case Report: The Use of Intravenous SMOFlipid Infusion to Treat Severe Asparaginase-Induced Hypertriglyceridemia in Two Pediatric Acute Lymphoblastic Leukemia Patients.

Front Pediatr 2021 22;9:660627. Epub 2021 Apr 22.

Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia.

Asparaginase-induced hypertriglyceridemia can have a spectrum of clinical presentations, from being asymptomatic to having life-threatening thrombosis or hyperviscosity syndrome. At present, there is no recommendation on routine lipid monitoring during asparaginase-containing treatment phase, nor a standardized guideline on its management. Two cases are presented here to illustrate the effects of concurrent infection on asparaginase-induced hypertriglyceridemia in patients with high-risk ALL and the use of SMOFlipid infusion as a treatment option in an acute situation. Read More

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The utility of therapeutic plasma exchange in Hyperviscosity syndrome associated with juvenile rheumatoid arthritis: A case report.

J Clin Apher 2021 May 4. Epub 2021 May 4.

Department of Pathology, Division of Transfusion Medicine and Hemostasis, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Hyperviscosity syndrome (HVS) is a life-threatening syndrome caused by high concentrations of large plasma proteins like IgM, rheumatoid factor, and other immune complexes, leading to increased blood viscosity and symptoms such as visual abnormalities, neurological impairment, bleeding diathesis, and thrombosis. While Waldenström's macroglobulinemia accounts for 80% to 90% of cases, HVS may develop in other clinical settings characterized by elevations in plasma proteins. Limited evidence currently exists describing the safety and efficacy of therapeutic plasma exchange (TPE) for the management of HVS secondary to non-neoplastic conditions. Read More

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Successful Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 (PIMS-TS) with Split Doses of Immunoglobulin G and Estimation of PIMS-TS Incidence in a County District in Southern Germany.

Healthcare (Basel) 2021 Apr 18;9(4). Epub 2021 Apr 18.

Department of Pediatrics, Hospital Ostallgäu-Kaufbeuren, 87600 Kaufbeuren, Germany.

Pediatric inflammatory multisystem syndrome temporally associated with SARS Cov2 (PIMS-TS) is a newly encountered disease in children sharing clinical features with Kawasaki disease, toxic shock syndrome, or macrophage-activating syndrome. Pathogenically, it is associated with immune-mediated post-infectious hyperinflammation leading to short-term myocardial injury with yet unknown long-term outcome. We herein present three cases of PIMS-TS treated in our institution with divided doses of immunoglobulins and high dose acetyl salicylic acid, according to existing Kawasaki disease guidelines. Read More

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Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management.

Lancet Haematol 2021 May;8(5):e365-e375

Division of Hematology, University of British Columbia, Vancouver, BC, Canada; Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, Vancouver General Hospital, Vancouver, BC, Canada. Electronic address:

This Review outlines a practical approach to assessing and managing polyclonal hypergammaglobulinaemia in adults. Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an important diagnostic clue of rare diseases such as histiocyte disorders, autoimmune lymphoproliferative syndrome, Castleman disease, and IgG4-related disease. Causes of polyclonal hypergammaglobulinaemia can be divided into eight categories: liver disease, autoimmune disease and vasculitis, infection and inflammation, non-haematological malignancy, haematological disorders, IgG4-related disease, immunodeficiency syndromes, and iatrogenic (from immunoglobulin therapy). Read More

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Reflections on the unexpected laboratory finding of hemorheological alterations observed in some haematological disorders.

Microvasc Res 2021 Apr 20;136:104171. Epub 2021 Apr 20.

Department of Health Promotion and Child Care, Internal Medicine and Medical Specialties, Università degli Studi di Palermo, Palermo, Italy. Electronic address:

Hyperviscosity syndrome is a clinical condition characterized by the slowing of blood flow through the vessels and it may be associated with several diseases. The nosographic classification of primary hyperviscosity conditions (Wells classification 1970) divided the primary hyperviscosity syndromes in polycythaemic, sclerocytemic and sieric. Recent and personal laboratory observations have highlighted an unexpected behaviour of the erythrocyte deformability observed in some haematological disorders such as polycythemia vera, multiple myeloma and monoclonal gammopathy of undetermined significance. Read More

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Profound Sudden Sensorineural Hearing Loss in Hematologic Malignancy: A Case for Urgent Cochlear Implantation With Discussion and Systematic Review of the Literature.

Otol Neurotol 2021 Mar 26. Epub 2021 Mar 26.

Division of Neurotology & Lateral Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To perform a systematic review of sensorineural hearing loss (SNHL) in hematologic malignancy; to describe an illustrative case of urgent cochlear implantation for bilateral profound SNHL and vestibular hypofunction in hyperviscosity syndrome; to suggest an approach to management of hyperviscosity syndrome-associated deafness with cochlear implantation.

Data Sources: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, systematic search of PubMed and Embase databases was undertaken for articles detailing clinical information about SNHL caused directly by hematologic malignancies.

Results: A total of 37 studies from 1989 to 2020 were qualitatively reviewed, the majority of which were case studies or case series. Read More

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Case Report: Management of a Patient With Chylomicronemia Syndrome During Pregnancy With Medical Nutrition Therapy.

Front Nutr 2021 5;8:602938. Epub 2021 Mar 5.

Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hypertriglyceridemia (HTG) during pregnancy may be accompanied by acute pancreatitis, hyperviscosity syndrome, and preeclampsia. HTG during pregnancy should be managed by a multidisciplinary team; however, no clinical guidelines exist for severe gestational HTG. We herein present a case of a 36-year-old in the first pregnancy (G1P0Ab0), with a history of severe HTG-induced necrotizing pancreatitis 9 years earlier. Read More

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Hyperviscosity-related retinopathy and serous macular detachment in Waldenström's macroglobulinemia: A mortal case in 5 years.

Eur J Ophthalmol 2021 Mar 15:11206721211002066. Epub 2021 Mar 15.

School of Medicine, College of Medicine, National Cheng Kung University, Tainan.

Purpose: To present a 5-year mortal case of Waldenström's macroglobulinemia-related retinopathy and serous macular detachment.

Case Report: A 63-year-old man, with unremarkable medical history, presented with bilateral decreased vision for 2 months. Fundus examination revealed bilateral scattered retinal hemorrhages, exudates, venous tortuosity, and serous macular detachment. Read More

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Efficacy of plasmapheresis as treatment for bilateral hyperviscosity syndrome related retinopathy in multiple myeloma.

Eur J Ophthalmol 2021 Feb 18:1120672121997069. Epub 2021 Feb 18.

Multizone Unit of Ophthalmology of Autonomous Province of Trento, Trento, Italy.

Purpose: To report a case of good clinical response to plasmapheresis as therapy for a bilateral hyperviscosity syndrome related retinopathy in a young patient with undiagnosed multiple myeloma (MM).

Methods: Case report.

Results: A 48-year-old caucasian man, previously diagnosed with monoclonal gammopathy of undetermined significance (MGUS), presented for medical attention for back ache and vision decrease, worst in the left eye. Read More

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February 2021

Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma.

Int J Mol Sci 2021 Feb 10;22(4). Epub 2021 Feb 10.

Department of Health Sciences, Gunma Paz University Graduate School of Health Sciences, 1-7-1, Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.

Immunoglobulin A (IgA)-albumin complexes may be associated with pathophysiology of multiple myeloma, although the etiology is not clear. Detailed structural analyses of these protein-protein complexes may contribute to our understanding of the pathophysiology of this disease. We analyzed the structure of the IgA-albumin complex using various electrophoresis, mass spectrometry, and in silico techniques. Read More

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February 2021

Smoldering multiple myeloma revealed by superior ophthalmic vein thrombosis.

Saudi J Ophthalmol 2020 Jan-Mar;34(1):62-65. Epub 2020 Nov 22.

Department of Neurology's, Habib Bourguiba Hospital, Sfax, Tunisia.

Superior ophthalmic vein thrombosis is a rare entity. It is associated with significant morbidities. It may present with dramatic clinical signs. Read More

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November 2020

Mondor's Disease: A Rare Cause of Chest Pain.

Eur J Case Rep Intern Med 2020 23;7(12):001984. Epub 2020 Nov 23.

Centro Hospitalar e Universitário de Coimbra, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.

Introduction: Chest pain is a very frequent reason for seeking medical care. When there is no obvious cause, patients are sometimes subjected to tests and treatments that may be unnecessary and potentially harmful. Mondor's disease is a rare but usually benign and self-limited entity characterized by thrombophlebitis in a specific region. Read More

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November 2020

Hyperviscosity Syndrome in Rheumatoid Arthritis.

J Rheumatol 2021 May 15;48(5):788-789. Epub 2021 Jan 15.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review.

Case Rep Hematol 2020 28;2020:8823877. Epub 2020 Dec 28.

University of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USA.

Primary plasma cell leukemia (pPCL) is an uncommon disease. IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases. IgM pPCL is quite rare with only a few cases published to date. Read More

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December 2020

A 67-Year-Old Woman With Recurrent Headache, Migratory Focal Symptoms, and Impaired Consciousness.

Headache 2020 11;60(10):2622-2630

Headache Center, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, Italy.

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November 2020

Acute Myocardial Infarction in an Adolescent Receiving Anagrelide for Essential Thrombocythemia with Underlying Persistent Coronary Endothelial Dysfunction.

Int Heart J 2020 Nov 13;61(6):1289-1293. Epub 2020 Nov 13.

Department of Cardiology, Saitama Medical University International Medical Center.

Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative disorder that is characterized by the overproduction of platelets and a marked increase in the numbers of mature megakaryocytes present in the bone marrow. Thrombohemorrhagic disorders are major morbidities of ET, especially those with mutations in the gene encoding Janus kinase 2 (JAK2). In this study, we report the case of an 18-year-old patient with ET carrying JAK2 mutation who developed acute ST-elevation myocardial infarction (STEMI) 5 months after a commencement of anagrelide. Read More

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November 2020

Coagulopathies in novel coronavirus (SARS-CoV-2) pandemic: Emerging evidence for hematologists.

Saudi J Biol Sci 2021 Jan 5;28(1):956-961. Epub 2020 Nov 5.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam AbdulRahman bin Faisal University, P.O. Box: 1982, Dammam 31441, Saudi Arabia.

The coronavirus disease (COVID-19), which is also known as acute respiratory syndrome coronavirus-2 (SARS-CoV2) is a transmissible disease, has phenotypes varying from asymptomatic to Acute Respiratory Distress Syndrome (ARDS) or multiple organ dysfunction syndrome (MODS) and ultimately death in certain cases. Coagulation disorders are being frequently reported amongst these patients and the pathogenesis is still not completely understood. Proposed mechanisms for these coagulopathies comprise a hypercoagulable state with micro- and/or macro-thrombosis in the vessels. Read More

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January 2021

Leukemic retinopathy secondary to hyperviscosity syndrome in acute lymphoblastic leukemia before and after treatment.

Authors:
A Pérez-Rueda

J Fr Ophtalmol 2021 Mar 5;44(3):477-479. Epub 2020 Nov 5.

Department of Ophthalmology, Torrecárdenas University Hospital, Almería, Spain. Electronic address:

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Daratumumab-Based Therapy for IgM Multiple Myeloma With Hyperviscosity Syndrome: A Case Report.

Clin Lymphoma Myeloma Leuk 2021 Jan 17;21(1):e21-e24. Epub 2020 Sep 17.

Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.

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January 2021

[When a urological emergency indicates an internal medical crisis : Priapism as the first clinical manifestation of leukemia].

Urologe A 2021 Jan;60(1):67-70

Klinik für Urologie und Kinderurologie, Universität des Saarlandes, Kirrberger Straße, Gebäude 6, 66424, Homburg/Saar, Deutschland.

Priapism as a sign of a severe hematological disease is a rare event, which has to be considered as both a urological and a hematological emergency that requires immediate treatment. This article describes a clinical case of priapism as the first clinical manifestation of a hitherto undiagnosed chronic myeloid leukemia (CML) and discusses the results of a literature review on this topic. Read More

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January 2021

Resolution of high output pulmonary edema due to hyperviscosity with plasma exchange in a patient with multiple myeloma- a case report.

Transfus Apher Sci 2020 Dec 3;59(6):102898. Epub 2020 Aug 3.

Department of Internal Medicine, Clinical Hematology and Bone Marrow Transplant Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Symptomatic hyperviscosity is an oncologic emergency which is suspected when patients with certain hematogical malignancies present with neurological symptoms. Hyperviscosity syndrome is a rare clinical manifestation in multiple myeloma. We describe a case of a 61 year old lady who developed pulmonary infiltrates after being diagnosed with multiple myeloma. Read More

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December 2020

Subjective intermittent colour vision loss as the initial presentation of chronic myeloid leukemia.

Am J Ophthalmol Case Rep 2020 Sep 8;19:100817. Epub 2020 Jul 8.

Department of Ophthalmology, University of Ottawa, The Ottawa Hospital and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Purpose: To report a case of subjective intermittent loss of bilateral colour vision and episodic white-out vision in a patient with undiagnosed chronic myeloid leukemia (CML).

Observations: A patient initially diagnosed with diabetic retinopathy presented with a chief complaint of subjective intermittent loss of colour vision in both eyes, as well as intermittent bilateral white-out vision. These symptoms previously went uninvestigated until a thorough history revealed concurrent constitutional symptoms including recent night sweats and fevers. Read More

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September 2020

Ixazomib Treatment of IgA Multiple Myeloma With Hyperviscosity Syndrome.

Clin Lymphoma Myeloma Leuk 2020 11 27;20(11):e832-e835. Epub 2020 Jun 27.

Department of Hematology, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

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November 2020

Initiation of peritoneal dialysis in a patient with chronic renal failure associated with tetralogy of Fallot: a case report.

BMC Nephrol 2020 07 15;21(1):277. Epub 2020 Jul 15.

Department of Nephrology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0375, Japan.

Background: Tetralogy of Fallot is the most common cyanotic congenital heart disease. Patients with the condition have a high risk of developing chronic kidney disease. Treatment of kidney disease in patients with complex hemodynamics presents unique challenges. Read More

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Bone Tumors: Multiple Myeloma.

Authors:
Shawn F Kane

FP Essent 2020 Jun;493:30-35

UNC Department of Family Medicine, 590 Manning Drive, Chapel Hill, NC 27599.

Multiple myeloma (MM) is a malignancy of bone marrow plasma cells that produce abnormal immunoglobulins. It is the second most common hematologic cancer and typically is diagnosed in individuals ages 65 to 74 years. MM is the final stage in a continuum that starts with monoclonal gammopathies of undetermined significance (MGUS), a premalignant condition characterized by production of abnormal immunoglobulins. Read More

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Diagnosis of a difficult to differentiate case of early-onset hyperviscosity syndrome caused by IgM type multiple myeloma: a case report.

Int J Hematol 2020 Nov 22;112(5):741-745. Epub 2020 Jun 22.

Department of Hematology, Osaka City General Hospital, 2-13-22, Miyakojima-hondori, Miyakojima-ku, Osaka, Osaka, 534-0021, Japan.

Hyperviscosity syndrome (HVS) can cause multiple organ damage if not treated immediately. IgM multiple myeloma (IgM MM) is a very rare form of myeloma with clinical features such as elevated serum IgM, and anemia, that resemble Waldenström macroglobulinemia (WM). Distinguishing between these two diseases is important, but can be a challenging problem. Read More

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November 2020

Confirmed Cryoglobulinemia and Hyperviscosity Syndrome Secondary to Multiple Myeloma-IgA Kappa from Routine Blood Test: a Case Report.

Clin Lab 2020 Jun;66(6)

Background: Cryoglobulins and hyperviscosity syndrome (HS) sometimes occur in multiple myeloma (MM), which are considered clinical emergencies. In laboratory practice, aspiration failure in routine blood tests sometimes occurs when the sample is inadequate. Here, a case of cryoglobulinemia and HS associated with advanced multiple myeloma was reported, which unusually is initially confirmed by aspiration failure in a routine blood test with sufficient sample. Read More

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Exploration in the mechanism of rhubarb for the treatment of hyperviscosity syndrome based on network pharmacology.

J Ethnopharmacol 2020 Oct 10;261:113078. Epub 2020 Jun 10.

Department of China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100039, China. Electronic address:

Ethnopharmacological Relevance: Hyperviscosity syndrome (HVS) is a major risk factor for thrombotic diseases. Rhubarb, well-known as a traditional Chinese medicine, exhibits multiple pharmacological activities, especially for promoting blood circulation to remove blood stasis (PBRB), which has been become a functional health food for decreasing the risk of cardiovascular diseases. However, due to the complexity of rhubarb components, it is still difficult to clarify the specific targets of effective substances in PBRB, and the pharmacodynamic mechanism needs to be further probed. Read More

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October 2020

Waldenstrom's Macroglobulinemia: A case report.

J Family Med Prim Care 2020 Mar 26;9(3):1768-1771. Epub 2020 Mar 26.

Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

Waldenstrom's macroglobulinemia (WM) is a rare and slowly progressive disorder, a variant of lymphoplasmacytic lymphoma, which needs therapy only when patient becomes symptomatic. WM presents usually with constitutional symptoms, organomegaly, cytopenias, and hyperviscosity syndrome. This neoplasm is composed of small lymphocytes, plasmacytoid lymphocytes, and plasma cells that typically involve the bone marrow, and it is associated with an immunoglobulin M (IgM) gammopathy. Read More

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Hyperviscosity Syndrome in Paraprotein Secreting Conditions Including Waldenstrom Macroglobulinemia.

Front Oncol 2020 19;10:815. Epub 2020 May 19.

Division of Hematology and Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.

Hyperviscosity syndrome is a serious complication associated with high levels of paraproteins in patients with hematological malignancies. Therapeutic advances in disease control may reduce the incidence of hyperviscosity syndrome; however, management of acute cases requires an understanding of key symptoms and prompt treatment to mitigate serious consequences. Read More

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