736 results match your criteria Hyperviscosity Syndrome


Dexamethasone implant for immunogammopathy maculopathy associated with IgA multiple myeloma.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841418820441. Epub 2019 Jan 8.

Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.

Background: We describe a case where hyperviscosity retinopathy and immunogammopathy maculopathy were the presenting features of IgA multiple myeloma and report the response of maculopathy to intravitreal injection of dexamethasone implants.

Case Presentation: A 56-year-old man presented at the Department of Ophthalmology with the chief complain of reduced vision for the past 10 days in both eyes. Ophthalmic examination revealed central retinal vein occlusion resembling signs with severe macular edema in both eyes with prominent serous macular detachment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2515841418820441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329023PMC
January 2019
1 Read

Cryoglobulinemia as a Possible Primer for TRALI: Report of a Case.

Lab Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.

Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/labmed/lmy073DOI Listing
January 2019
1 Read

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NRL.0000000000000197DOI Listing
November 2018
7 Reads

Vasoproliferative retinopathy secondary to Waldenström's disease.

Arch Soc Esp Oftalmol 2019 Feb 11;94(2):85-89. Epub 2018 Oct 11.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

A 66 year-old patient, monitored for diabetic retinopathy refractory to multiple treatment methods despite a good metabolic control, referred to progressive weight loss. For this reason, a systemic study was performed, detecting anaemia, elevation of the erythrocyte sedimentation rate, and hyperproteinaemia due to elevated serum levels of monoclonal IgM. Subsequently, by performing a bone marrow biopsy and genetic study, the diagnosis of Waldenström macroglobulinaemia was made. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2018.09.006DOI Listing
February 2019
6 Reads

Hyperviscosity syndrome in splenic marginal zone lymphoma.

Blood 2018 Oct;132(15):1627

Keck School of Medicine of the University of Southern California.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-07
Publisher Site
http://dx.doi.org/10.1182/blood-2018-07-863787DOI Listing
October 2018
4 Reads

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.

J Ophthalmol 2018 9;2018:8629429. Epub 2018 Sep 9.

Department of Ophthalmology, Taichung Veterans General Hospital, Taichung 407, Taiwan.

Purpose: To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients.

Methods: From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2013, a total of 22919 subjects with RVO were enrolled in the RVO group, and 114595 propensity score (PS)-matched non-RVOs were enrolled in the comparison group. PS matching was based on age, gender, obesity, diabetes, hypertension, hyperlipidemia, coronary artery disease, atrial fibrillation, hyperviscosity syndrome, Charlson comorbidity index, glaucoma, and the use of antithrombotic drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/8629429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151214PMC
September 2018
6 Reads

Oncologic Emergencies: Recognition and Initial Management.

Am Fam Physician 2018 Jun;97(11):741-748

Novant health Family Medicine Residency, Charlotte, NC, USA.

Most oncologic emergencies can be classified as metabolic, hematologic, structural, or treatment related. Tumor lysis syndrome is a metabolic emergency that presents as severe electrolyte abnormalities. Stabilization is focused on vigorous rehydration, maintaining urine output, and lowering uric acid levels. Read More

View Article

Download full-text PDF

Source
June 2018
5 Reads

Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia.

Hematol Oncol 2018 Sep 7. Epub 2018 Sep 7.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hon.2539DOI Listing
September 2018
7 Reads

Initial Evaluation of the Patient with Waldenström Macroglobulinemia.

Hematol Oncol Clin North Am 2018 10 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2018.05.008DOI Listing
October 2018
4 Reads

Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia.

J Clin Apher 2018 Oct 6;33(5):611-615. Epub 2018 Sep 6.

Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.

Background: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation.

Objectives: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21655DOI Listing
October 2018
14 Reads

Rapid Fire: Acute Blast Crisis/Hyperviscosity Syndrome.

Emerg Med Clin North Am 2018 Aug 11;36(3):603-608. Epub 2018 Jun 11.

Department of Emergency Medicine, Wexner Medical Center at The Ohio State University, 760 Prior Hall, 376 West 10th Avenue, Columbus, OH 43210, USA.

Emergency providers are likely to encounter patients with acute and chronic leukemias. In some cases, the first presentation to the emergency department may be for symptoms related to blast crisis and leukostasis. Making a timely diagnosis and consulting a hematologist can be life saving. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.emc.2018.04.005DOI Listing
August 2018
6 Reads

Idelalisib in a patient with refractory Waldenström's macroglobulinemia complicated by anuric renal failure: a case report.

J Med Case Rep 2018 Jun 12;12(1):164. Epub 2018 Jun 12.

Hematology Department, University Hospital of Nancy, 1, allée du Morvan, 54511, Vandoeuvre Cedex, France.

Background: Waldenström's macroglobulinemia is a rare B-cell lymphoma. The gold standard treatment for Waldenström's macroglobulinemia is an anti-CD20 antibody (rituximab) in combination with alkylating agents and dexamethasone. Treatment targeting the B-cell receptor such as ibrutinib (but not idelalisib) is currently approved for treatment of patients with relapsed or refractory Waldenström's macroglobulinemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-018-1694-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996512PMC
June 2018
3 Reads

Use of intravenous iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension.

Int J Cardiol 2018 Sep 19;267:79-83. Epub 2018 May 19.

Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College School of Medicine, London, UK. Electronic address:

Background: Secondary erythrocytosis is common in patients with cyanosis secondary to congenital heart disease (CHD) and/or pulmonary hypertension (PH). This compensatory mechanism aims at increasing oxygen delivery to the tissues, but it requires adequate iron stores. Optimal methods of iron supplementation in this setting remain controversial, with fears of excessive erythropoiesis and hyperviscosity symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2018.05.062DOI Listing
September 2018
4 Reads

MR imaging findings in some rare neurological complications of paediatric cancer.

Insights Imaging 2018 Jun 15;9(3):313-324. Epub 2018 May 15.

Department of Radiology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13244-018-0628-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991004PMC
June 2018
5 Reads

Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats.

Microvasc Res 2018 09 6;119:91-97. Epub 2018 May 6.

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Background: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms.

Objective: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied.

Methods: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mvr.2018.04.005DOI Listing
September 2018
7 Reads

Increased plasma viscosity in plasma cell dyscrasia and whole blood viscosity in polycythemia vera.

Clin Hemorheol Microcirc 2018 ;70(1):59-67

Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background: Although hyperviscosity syndrome in plasma cell dyscrasia (PCD) and thrombosis in myeloproliferative neoplasm (MPN) are major causes of morbidity and mortality, blood viscosity measurements are often underutilized.

Objective: This study aimed to characterize whether whole blood viscosity (WBV) or plasma viscosity (PV) could be predictive of hyperviscosity syndrome in PCD and could be elevated in subgroups of MPN.

Methods: A total of 75 patients with hematologic diseases: PCD (n = 26), MPN (n = 25) including polycythemia vera (P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/CH-170304DOI Listing
November 2018
13 Reads

Blood Is Thicker: Hyperviscosity Syndrome.

Am J Med 2018 Aug 22;131(8):916-917. Epub 2018 Mar 22.

Department of Medicine, University of California, San Francisco; Department of Medicine, Medical Service, VA Medical Center, San Francisco, Calif.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029343183021
Publisher Site
http://dx.doi.org/10.1016/j.amjmed.2018.02.022DOI Listing
August 2018
8 Reads

Therapeutic plasma exchange for hyperviscosity syndrome secondary to high rheumatoid factor.

Transfus Apher Sci 2018 Apr 15;57(2):225-227. Epub 2018 Feb 15.

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, United States.

Hyperviscosity syndrome (HVS) is most commonly associated with Waldenstrom's macroglobulinemia, where it may be life-threatening. HVS may also occur in autoimmune diseases; data pertaining to efficacy of therapeutic plasma exchange (TPE) in HVS arising in non-malignant gammopathy are limited. We report a case of 71-year-old female with erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal <35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis and plasma viscosity (8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transci.2018.02.004DOI Listing
April 2018
6 Reads

The use of emergency apheresis in the management of plasma cell disorders.

Transfus Apher Sci 2018 Feb 20;57(1):35-39. Epub 2018 Feb 20.

Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Division of Hematology, Therapeutic Apheresis Unit and Blood Bank, Istanbul, Turkey. Electronic address:

Hyperviscosity syndrome (HVS) develops most commonly in Waldenström's macroglobulinemia (WM) and multiple myeloma (MM). Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The most commonly used replacement fluid is 4%-5% human albumin in physiologic saline. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14730502183004
Publisher Site
http://dx.doi.org/10.1016/j.transci.2018.02.014DOI Listing
February 2018
13 Reads

Hyperviscosity syndrome.

Intensive Care Med 2018 07 23;44(7):1151-1152. Epub 2018 Feb 23.

Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, 75012, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-018-5087-yDOI Listing
July 2018
4 Reads

Blood rheology of angina pectoris patients with myocardial injury after ischemia reperfusion and its effect on thromboxane B levels.

Exp Ther Med 2018 Jan 6;15(1):769-772. Epub 2017 Nov 6.

Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B (TXB) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2017.5449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772472PMC
January 2018
5 Reads

Intensely Pruritic Papules and Plaques in Waldenstrom's Macroglobulinemia.

Ann Dermatol 2018 Feb 26;30(1):87-90. Epub 2017 Dec 26.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Waldenstrom's macroglobulinemia (WM) is lymphoplasmacytoid malignancy that affects B lymphocytes. Cutaneous involvement of WM is rare, but various cutaneous manifestations have been reported. These findings are due to various pathological processes including direct invasion of tumor cells into the skin, deposition of paraproteins, hyperviscosity syndrome, and cryoglobulinemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2018.30.1.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762484PMC
February 2018
6 Reads

A clinical picture of pulmonary embolism revealing light-chain myeloma.

Clin Case Rep 2017 12 2;5(12):2044-2046. Epub 2017 Nov 2.

Department of Clinical Biochemistry and Toxicology Faculty of Medicine and Pharmacy Mohammed V Military Teaching Hospital Mohammed V University Rabat Morocco.

We are highlighting on the particularity of a clinical picture of pulmonary embolism revealing light-chain myeloma in a 56-year-old male patient. Myeloma remains a rare affection. Even though its revelation through pulmonary embolism remains rare, it can be explained by hyperviscosity syndrome accompanying it. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.1234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715419PMC
December 2017
15 Reads

A Case of Advanced Glaucoma with Increased Episcleral Venous Pressure in a 17-Year-Old with Eisenmenger Syndrome.

Case Rep Ophthalmol Med 2017 23;2017:5808047. Epub 2017 Oct 23.

Mater Dei Hospital, Msida, Malta.

Eisenmenger syndrome refers to reversal of shunt and central cyanosis due to pulmonary hypertension induced by congenital heart disease with a large systemic-to-pulmonary shunt. We report a case of a 17-year-old man with Eisenmenger syndrome who presented with gradual deterioration in visual acuity and was diagnosed with advanced secondary open angle glaucoma. There have been reports of patients suffering from thrombosis due to hyperviscosity associated with this syndrome; however, to our knowledge, the association of secondary open angle glaucoma with Eisenmenger syndrome has not yet been documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/5808047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672606PMC
October 2017
17 Reads

Multiple Myeloma Presenting as Acute Renal Failure in the Absence of Other Characteristic Features.

Cureus 2017 Sep 20;9(9):e1703. Epub 2017 Sep 20.

Hematology and Oncology, University of Arizona Cancer Center.

This case report describes a 54-year-old, asymptomatic man who presented with hyperkalemia on routine lab testing who was later found to have acute renal failure, unresponsive to fluid resuscitation, with minimal improvement after hemodialysis. After a comprehensive evaluation ruled out common causes of acute renal failure, the patient underwent testing with a bone survey, urine protein electrophoresis (UPEP), serum protein electrophoresis (SPEP), and immunoelectrophoresis for suspected plasma cell dyscrasia and received plasmapheresis for hyperviscosity syndrome and nephrotoxicity, which resulted in improved renal function. Lab results showed monoclonal gammopathy, elevated serum free light chains, and Bence Jones protein in the urine with a follow-up bone marrow biopsy indicating plasma cell dyscrasia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.1703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690288PMC
September 2017
11 Reads

[Expert consensus for the diagnosis and treatment of patients with renal impairment of multiple myeloma].

Authors:

Zhonghua Nei Ke Za Zhi 2017 Nov;56(11):871-875

Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2017.11.022DOI Listing
November 2017
8 Reads

Oncologic Mechanical Emergencies.

Hematol Oncol Clin North Am 2017 12;31(6):927-940

Division of Pulmonary and Critical Care, University of Maryland School of Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA. Electronic address:

Prevalence of cancer and its various related complications continues to rise. Increasingly these life-threatening complications are initially managed in the emergency department, making a prompt and accurate diagnosis crucial to effectively institute the proper treatment and establish goals of care. The following oncologic emergencies are reviewed in this article: pericardial tamponade, superior vena cava syndrome, brain metastasis, malignant spinal cord compression, and hyperviscosity syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2017.08.001DOI Listing
December 2017
7 Reads

[Hyperviscosity syndrome in Waldenstrom's macroglobulinemia].

J Fr Ophtalmol 2017 Nov 6;40(9):e323-e325. Epub 2017 Oct 6.

Service d'ophtalmologie, DHU vision et handicaps, hôpital Avicenne, 125, rue de Stalingrad, 93000 Bobigny, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2016.05.015DOI Listing
November 2017
3 Reads

Hypoglossal Nerve Mononeuropathy as the First Presenting Symptom of Progressing Multiple Myeloma.

World J Oncol 2017 Feb 23;8(1):15-17. Epub 2017 Feb 23.

Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 07082, USA.

Multiple myeloma (MM) rarely presents with a primary neurological dysfunction, and if it does it is usually due to a plasmacytoma. This is the first case to discuss hypoglossal nerve dysfunction as the first sign of MM progression secondary to severe pathophysiologic bone lysis. A PubMed-based literature search was completed on April 17, 2016 for the terms "multiple myeloma" and "hypoglossal nerve neuropathy". Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14740/wjon1000wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624656PMC
February 2017
21 Reads

Association between retinal vein occlusion and an increased risk of acute myocardial infarction: A nationwide population-based follow-up study.

PLoS One 2017 12;12(9):e0184016. Epub 2017 Sep 12.

Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.

Objective: To investigate a possible association between retinal vein occlusion (RVO) and an increased risk of developing acute myocardial infarction (AMI).

Design: A population-based retrospective cohort study using the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 1st January, 2001 to 31st December, 2013.

Methods: A total of 37921 subjects with RVO were enrolled in the RVO group, and 113763 subjects without RVO were enrolled in the comparison group. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184016PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595302PMC
October 2017
21 Reads

Lymphoproliferative disease with mixed cryoglobulinemia and hyperviscosity syndrome in an HIV-infected patient: HCV is the only culprit.

New Microbiol 2017 Oct 21;40(4):289-290. Epub 2017 Aug 21.

University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.

The availability of direct antiviral agents (DAAs) offers the possibility to treat HCV-infected patients with a high rate of efficacy and a good safety profile. Little is known about the benefit of DAAs on HCV-related hematological diseases and their complications. We describe the case of an HIV/HCV-infected patient with HCV-related chronic lymphoproliferative disease, mixed cryoglobulinemia and hyperviscosity syndrome. Read More

View Article

Download full-text PDF

Source
October 2017
8 Reads

Cardiovascular Oncologic Emergencies.

Cardiology 2017;138(3):147-158. Epub 2017 Jun 28.

Department of Inpatient Medicine, Banner University of Arizona, Tucson, AZ, USA.

Oncologic emergencies can present either as a progression of a known cancer or as the initial presentation of a previously undiagnosed cancer. In most of these situations, a very high degree of suspicion is required to allow prompt assessment, diagnosis, and treatment. In this article, we review the presentation and management of cardiovascular oncologic emergencies from primary and metastatic tumors of the heart and complications such as pericardial tamponade, superior vena cava syndrome, and hyperviscosity syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000475491DOI Listing
August 2018
23 Reads

Clinical conditions responsible for hyperviscosity and skin ulcers complications.

Clin Hemorheol Microcirc 2017 ;67(1):25-34

Dipartimento Biomedico di Medicina Interna eSpecialistica, Università di Palermo, Italy.

In this brief review, we have examined some clinical conditions that result to be associated to an altered hemorheological profile and at times accompanied by skin ulcers. This skin condition may be observed in patients with the following condtions, such as primary polycythemic hyperviscosity (polycythemia, thrombocytemia) treated with hydroxyurea, primary plasma hyperviscosity (multiple myeloma, cryoglobulinemia, cryofibrinogenemia, dysfibrinogenemia, and connective tissue diseases), primary sclerocythemic hyperviscosity (hereditary spherocytosis, thalassemia, and sickle cell disease). In addition, it may be present in patients with secondary hyperviscosity conditions such as diabetes mellitus, arterial hypertension, critical limb ischemia and chronic venous insufficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/CH-160218DOI Listing
January 2018
25 Reads

Normothermic Cardiopulmonary Bypass in Patient With Waldenström's Macroglobulinemia and Cryoglobulinemia: A Case Report.

A A Case Rep 2017 Sep;9(6):162-163

From the Department of Anesthesiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

Waldenström's macroglobulinemia (WM) manifests as hyperviscosity syndrome. Cryoglobulinemia, which may increase blood viscosity or induce thrombosis in association with decreased body temperature, can occur in combination with WM. We describe the management of an 82-year-old woman with WM, hyperviscosity syndrome, and cryoglobulinemia who required open aortic valve replacement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/XAA.0000000000000555DOI Listing
September 2017
12 Reads

[Severe hypertriglyceridemia : Diagnostics and new treatment principles].

Internist (Berl) 2017 Aug;58(8):866-876

Charité, Universitätsklinik Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For diagnosis, secondary factors have to be excluded and treated before further genetic tests are considered. Typical symptoms in almost all patients are recurrent, sometimes severe abdominal pain attacks, which can result in acute pancreatitis, the most important, sometimes life-threatening complication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00108-017-0234-zDOI Listing
August 2017
7 Reads

[Retinal pigment epithelial detachment in hyperviscosity syndrome].

Ophthalmologe 2018 04;115(4):322-325

Klinik für Augenheilkunde, Universitätsklinikum Münster, Domagkstrasse 15, 48149, Münster, Deutschland.

We present a case of a 57-year-old woman who reported bilateral visual impairment since 2 weeks. She had a medical history of congenital, cyanotic heart failure. Funduscopic examination revealed serous retinal detachment on the left side, central subneurosensory detachment on the right side, retinal vessel tortuosity and multiple retinal haemorrhages in the periphery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00347-017-0505-zDOI Listing
April 2018
24 Reads

Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade.

BMC Cancer 2017 05 12;17(1):327. Epub 2017 May 12.

Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.

Background: Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested.

Case Presentation: We report a 60-year-old Caucasian male attended our hospital with a bulky lymph node mass in the right axilla. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-017-3313-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429577PMC
May 2017
36 Reads

Clinical disorders responsible for plasma hyperviscosity and skin complications.

Eur J Intern Med 2017 Jul 5;42:24-28. Epub 2017 Apr 5.

Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Italy.

In this brief review, we have examined some clinical disorders which are associated to an altered hemorheological profile and at times accompanied by skin ulcers. This skin condition may be, in fact, observed in patients with primary plasma hyperviscosity such as multiple myeloma, Waldenstrom macroglobulinemia, cryoglobulinemia, cryofibrinogenemia, dysfibrinogenemia and connective tissue diseases. It must be underlined that the altered hemorheological pattern is not the only responsible for this skin complication but, as it worsens the microcirculatory flow, it contributes to determine the occurrence of the skin ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2017.04.001DOI Listing
July 2017
9 Reads

MULTIMODALITY OCULAR IMAGING IN A CASE REPORT OF HYPERVISCOSITY SYNDROME ASSOCIATED WITH LYMPHOPLASMACYTIC LEUKEMIA: THE IMAGES TELL THE STORY.

Retin Cases Brief Rep 2017 Mar 22. Epub 2017 Mar 22.

Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.

Purpose: To report the clinical course of a patient with ocular manifestations of hyperviscosity syndrome associated with Waldenström macroglobulinemia, and for the first time, video imaging of mobile emboli in the conjunctival and retinal vasculature.

Methods And Patient: A 60-year-old woman with newly diagnosed Waldenström macroglobulinemia, with no visual complaints was evaluated by the Ophthalmology service for a baseline ocular examination.

Results: At presentation, ocular examination revealed a visual acuity of 20/25 in each eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICB.0000000000000565DOI Listing
March 2017
5 Reads

Management of neuro-oncologic emergencies.

Authors:
J T Jo D Schiff

Handb Clin Neurol 2017 ;141:715-741

Neuro-Oncology Center, University of Virginia, Charlottesville, VA, USA. Electronic address:

Patients with brain tumors and systemic malignancies are subject to diverse neurologic complications that require urgent evaluation and treatment. These neurologic conditions are commonly due to the tumor's direct effects on the nervous system, such as cerebral edema, increased intracranial pressure, seizures, spinal cord compression, and leptomeningeal metastases. In addition, neurologic complications can develop as a result of thrombocytopenia, coagulopathy, hyperviscosity syndromes, infection, immune-related disorders, and adverse effects of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-444-63599-0.00039-9DOI Listing
March 2017
11 Reads

Plasma exchange in the intensive care unit: Technical aspects and complications.

J Clin Apher 2017 Dec 1;32(6):405-412. Epub 2017 Feb 1.

Medical Intensive Care Department, Saint Louis University Hospital, Paris, France.

Background: Data on plasma exchange therapy in the intensive care unit (ICU) setting are scarce. We aimed to describe the technical aspects and the adverse events associated with the procedure in critically ill patients.

Methods: All adult patients treated by plasma exchange in the medical ICU of the Saint-Louis university hospital between January 1, 2013 and March 31, 2015 were prospectively included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21529DOI Listing
December 2017
10 Reads

Capillary electrophoresis analysis of N-glycosylation changes of serum paraproteins in multiple myeloma.

Electrophoresis 2017 09 21;38(17):2115-2123. Epub 2017 Feb 21.

Horváth Csaba Memorial Institute for Bioanalytical Research, University of Debrecen, Hungary.

Multiple myeloma (MM) is an immedicable malignancy of the human plasma cells producing abnormal antibodies (also referred to as paraproteins) leading to kidney problems and hyperviscosity syndrome. In this paper, we report on the N-glycosylation analysis of paraproteins from total human serum as well as the fragment crystallizable region (F ) and fragment antigen binding (F ) κ/λ light chain fractions of papain digested immunoglobulins from multiple myeloma patients. CE-LIF detection was used for the analysis of the N-glycans after endoglycosidase (PNGase F) mediated sugar release and fluorophore labeling (APTS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/elps.201700006DOI Listing
September 2017
18 Reads

[PET-CT Manifestation and Clinical Analysis of Waldenstrom Macroglobulinemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016 Dec;24(6):1782-1786

Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. E-mail:

Objective: To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia(WM) .

Methods: The clinical features, laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.

Results: The average age of 12 patients with WM was 63. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7534/j.issn.1009-2137.2016.06.030DOI Listing
December 2016
7 Reads

CNS Vasculitis Associated with Waldenström Macroglobulinemia.

Case Rep Neurol Med 2016 12;2016:2510573. Epub 2016 Oct 12.

Department of Medicine, University of Hawaii, Honolulu, HI, USA; Department of Neurology, Straub Clinics and Hospital, Honolulu, HI, USA.

Waldenström macroglobulinemia (WM) is an indolent B cell lymphoproliferative disorder with monoclonal IgM secretion. We present a patient with WM who presented with multifocal acute cortical ischemic strokes and was found to have central nervous system (CNS) vasculitis. Workup was negative for cryoglobulins and hyperviscosity syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2016/2510573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080500PMC
October 2016
16 Reads

Biochemical and nutritional factors associated with blood viscosity in adults living in a mountain chain, (Imbabura), Ecuador.

Invest Clin 2016 Sep;57(3):293-304

The association of blood viscosity (BV) with hypertension and diabetes mellitus type 2 indicates that it should be considered, especially in populations living in mountain chains where the hemoglobin and hematocrit values are higher. In fact, this work analyzed the association of BV with nutritional and biochemical risk factors in the development of cardio metabolic diseases in healthy adults (20-60 years old; 46.39% female and 53. Read More

View Article

Download full-text PDF

Source
September 2016
1 Read

Bilateral Central Retinal Vein Occlusion as Presenting Feature of Chronic Myeloid Leukemia.

Middle East Afr J Ophthalmol 2016 Jul-Sep;23(3):253-5

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Central retinal vein occlusion (CRVO) is a common pathology of the retinal vasculature. Patients with CRVO usually present with a drop in visual acuity. The condition bears no specific therapy; treatment is aimed at the management of potentially blinding complications, of which there are many. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0974-9233.186113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968147PMC
March 2017
26 Reads

Immunoglobulin M 'Flare' Seen in a Case of Waldenstrom's Macroglobulinemia: Successfully Managed by Therapeutic Plasma Exchange.

Indian J Hematol Blood Transfus 2016 Jun 29;32(Suppl 1):148-51. Epub 2015 Sep 29.

Department of Immunohematology & Blood Transfusion, MCH, Kolkata, West Bengal 700073 India.

Therapeutic plasma exchange (TPE) is a conjunctive modality of treatment along with rituximab to decrease paraproteinemia associated with hyperviscosity. Here we narrate our experience in treating a diagnosed case of Waldenstrom's macroglobulinemia in 70 years old male patient with moderate anemia and severe features of hyperviscosity syndrome by serial TPE and rituximab combined with bortezomib. The patient was relieved of his symptoms after initial two TPE procedures performed on alternative day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12288-015-0603-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925533PMC
June 2016
8 Reads

Young Ischemic Stroke in Association with Ovarian Hyperstimulation Syndrome.

J Stroke Cerebrovasc Dis 2016 Sep 5;25(9):e134-40. Epub 2016 Jul 5.

Department of Neurology, Detroit Medical Center/Wayne State University, Detroit, MI.

Background: Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially fatal complication of medical ovarian stimulation. Uncommonly, it is associated with thromboembolic complications with venous thrombosis being more common than arterial thromboembolic events. We present a case of cerebral infarction in the setting of severe OHSS secondary to in vitro fertilization treatment with no residual neurological deficits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.04.023DOI Listing
September 2016
3 Reads