1,527 results match your criteria Hyperviscosity Syndrome


Associations between biochemical components of human semen with seminal conditions.

Syst Biol Reprod Med 2018 Nov 30:1-9. Epub 2018 Nov 30.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

The aim of the study was to assess whether abnormal levels of seminal biochemical components could be associated with semen alterations and infertility. In this study, 92 human ejaculates from selected men were analyzed. Albumin, estradiol, ferritin, total proteins (TP), folic acid (FA), vitamin B12, alkaline phosphatase (ALP), creatine kinase (CK), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase were evaluated. Read More

View Article
November 2018

Black stomach: acute gastric wall ischemia due to polycythemia of an unknown origin.

Rev Esp Enferm Dig 2018 Nov 19;111. Epub 2018 Nov 19.

Gastroenterology, Hospital Amato Lusitano, ULS Castelo Branco, Portugal.

Acute ischemia of the gastric mucosa, resulting in a black stomach, is a very rare event given the blood supply of the stomach, with a rich collateral blood flow system. We present the case of a 65-year-old man, with polycythemia of unknown origin under investigation, presented to the emergency department with a history of diffuse abdominal pain and hematemesis. Blood tests revealed a hemoglobin level of 22 g/dL. Read More

View Article
November 2018
4 Reads

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

View Article
November 2018
3 Reads

Waldenström macroglobulinemia: 2018 update on diagnosis, risk stratification, and management.

Authors:
Morie A Gertz

Am J Hematol 2018 Oct 17. Epub 2018 Oct 17.

Division of Hematology, Mayo Clinic, Rochester, Minnesota.

Disease Overview: Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity.

Diagnosis: Presence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis. Read More

View Article
October 2018
13 Reads

Plasmapheresis for hypertriglyceridemia: The association between blood viscosity and triglyceride clearance rate.

J Clin Lab Anal 2018 Oct 15:e22688. Epub 2018 Oct 15.

Division of Nephrology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.

Objectives: Several factors in double filtration plasmapheresis (DFPP) were associated with triglyceride (TG) clearance rate. This study examines whether baseline whole blood viscosity was a predictor for efficient TG removal.

Methods: Adult subjects who receiving DFPP for hyperlipidemia in Taoyuan General Hospital from January 2015 to March 2018 were classified into efficient and inefficient TG removal according to TG removal rate ≥50% vs <50%. Read More

View Article
October 2018
1 Read

Vasoproliferative retinopathy secondary to Waldenström's disease.

Arch Soc Esp Oftalmol 2018 Oct 11. Epub 2018 Oct 11.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

A 66 year-old patient, monitored for diabetic retinopathy refractory to multiple treatment methods despite a good metabolic control, referred to progressive weight loss. For this reason, a systemic study was performed, detecting anaemia, elevation of the erythrocyte sedimentation rate, and hyperproteinaemia due to elevated serum levels of monoclonal IgM. Subsequently, by performing a bone marrow biopsy and genetic study, the diagnosis of Waldenström macroglobulinaemia was made. Read More

View Article
October 2018
4 Reads

Hyperviscosity syndrome in splenic marginal zone lymphoma.

Blood 2018 Oct;132(15):1627

Keck School of Medicine of the University of Southern California.

View Article
October 2018
3 Reads

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.

J Ophthalmol 2018 9;2018:8629429. Epub 2018 Sep 9.

Department of Ophthalmology, Taichung Veterans General Hospital, Taichung 407, Taiwan.

Purpose: To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients.

Methods: From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2013, a total of 22919 subjects with RVO were enrolled in the RVO group, and 114595 propensity score (PS)-matched non-RVOs were enrolled in the comparison group. PS matching was based on age, gender, obesity, diabetes, hypertension, hyperlipidemia, coronary artery disease, atrial fibrillation, hyperviscosity syndrome, Charlson comorbidity index, glaucoma, and the use of antithrombotic drugs. Read More

View Article
September 2018
5 Reads

IgM plasma cell myeloma in the era of novel therapy: a Clinicopathologic study of 17 cases.

Hum Pathol 2018 Sep 25. Epub 2018 Sep 25.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

IgM plasma cell myeloma (PCM) is a rare subtype of myeloma and its response to novel therapies has not been fully characterized. We describe clinicopathological features and outcome of 17 patients with IgM PCM (11 men and 6 women) with a median age of 63years. Patients presented with serum hyperviscosity (77%), bone lesions (71%), anemia (65%), renal dysfunction (53%), and hypercalcemia (35%). Read More

View Article
September 2018
1 Read
2.770 Impact Factor

Oncologic Emergencies: Recognition and Initial Management.

Am Fam Physician 2018 Jun;97(11):741-748

Novant health Family Medicine Residency, Charlotte, NC, USA.

Most oncologic emergencies can be classified as metabolic, hematologic, structural, or treatment related. Tumor lysis syndrome is a metabolic emergency that presents as severe electrolyte abnormalities. Stabilization is focused on vigorous rehydration, maintaining urine output, and lowering uric acid levels. Read More

View Article
June 2018
3 Reads

Pulmonary Arteriovenous Malformations.

QJM 2018 Sep 12. Epub 2018 Sep 12.

Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

A 34-year-old gentleman, presented with a recurrent headache, redness of the face, and shortness of breath for six months. He had congestive palpebral conjunctiva, reddish face and drumstick appearance of the fingers with loss of Lovibond angle. His SpO2 82 % at room air. Read More

View Article
September 2018
3 Reads

Red blood cell exchange in patients with sickle cell disease-indications and management: a review and consensus report by the therapeutic apheresis subsection of the AABB.

Transfusion 2018 Aug;58(8):1965-1972

Department of Pathology, University of Chicago, Chicago, Illinois.

Background: A prior practice survey revealed variations in the management of patients with sickle cell disease (SCD) and stressed the need for comprehensive guidelines. Here we discuss: 1) common indications for red blood cell exchange (RCE), 2) options for access, 3) how to prepare the red blood cells (RBCs) to be used for RCE, 4) target hemoglobin (Hb) and/or hematocrit (Hct) and HbS level, 5) RBC depletion/RCE, and 6) some complications that may ensue.

Study Design And Methods: Fifteen physicians actively practicing apheresis from 14 institutions representing different areas within the United States discussed how they manage RCE for patients with SCD. Read More

View Article
August 2018
1 Read

Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia.

Hematol Oncol 2018 Sep 7. Epub 2018 Sep 7.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Read More

View Article
September 2018
5 Reads

Initial Evaluation of the Patient with Waldenström Macroglobulinemia.

Hematol Oncol Clin North Am 2018 Oct 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More

View Article
October 2018
2 Reads

Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia.

J Clin Apher 2018 Oct 6;33(5):611-615. Epub 2018 Sep 6.

Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.

Background: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation.

Objectives: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP. Read More

View Article
October 2018
8 Reads

Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only.

Am J Ophthalmol Case Rep 2018 Dec 29;12:49-51. Epub 2018 Aug 29.

Department of Ophthalmology, Meir Medical Center, Kfar Sava, Israel.

Purpose: To describe the clinical presentation and imaging features of a patient presenting with bilateral central retinal vein occlusion (CRVO), who was subsequently diagnosed with hyperviscosity retinopathy due to B cell lymphoproliferative disease, and had a good response to systemic immunosuppressive therapy.

Observations: A clinical case report of an 87-year-old woman who presented with bilateral CRVO. Visual acuity, clinical examination, spectral domain optical coherence tomography (SD-OCT), color fundus photography and systemic evaluation were obtained. Read More

View Article
December 2018

Fetal vascular malperfusion, an update.

APMIS 2018 Jul;126(7):561-569

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Read More

View Article
July 2018
2 Reads

Predictors of symptomatic hyperviscosity in Waldenström macroglobulinemia.

Am J Hematol 2018 Nov 2;93(11):1384-1393. Epub 2018 Oct 2.

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Symptomatic hyperviscosity is a well-established phenomenon in Waldenström macroglobulinemia (WM). Monoclonal IgM can variably impact intrinsic serum viscosity, leading to widely disparate symptomatic thresholds for development of hyperviscosity-related symptoms. Data regarding the predictors of symptomatic hyperviscosity and outcomes related to this complication remain scarce and a recent study proposed that IgM >6000 mg/dL be considered a new criterion for initiating therapy in otherwise asymptomatic (smoldering) WM to pre-empt hyperviscosity-related injury. Read More

View Article
November 2018
12 Reads
3.800 Impact Factor

Acute hyperviscosity: syndromes and management.

Authors:
Morie A Gertz

Blood 2018 Sep 13;132(13):1379-1385. Epub 2018 Aug 13.

Mayo Clinic, Rochester, MN.

Plasma hyperviscosity is a rare complication of both monoclonal and polyclonal disorders associated with elevation of immunoglobulins. Asymptomatic patients with an elevation in the serum viscosity do not require plasma exchange, and the majority will have other indications for therapeutic intervention. For patients with hemorrhagic or central nervous system manifestations, plasma exchange is the therapy of choice and is relatively safe. Read More

View Article
September 2018
1 Read

Cardiovascular adverse events in modern myeloma therapy - Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA).

Haematologica 2018 Sep 26;103(9):1422-1432. Epub 2018 Jul 26.

Department of Medicine I, Hematology, Oncology & Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, Germany.

Cardiovascular disease in patients with multiple myeloma may derive from factors unrelated to the disease (age, diabetes, dyslipidemia, obesity, prior cardiovascular diseases), related to the disease (cardiac AL-amyloidosis, hyperviscosity, high-output failure, arteriovenous shunting, anemia, renal dysfunction) and/or related to anti-myeloma treatment (anthracyclines, corticosteroids, alkylating agents, immunomodulatory drugs, proteasome inhibitors). Good knowledge of cardiovascular events, effective dose reductions, prevention and management of early and late cardiovascular side effects of chemotherapeutic agents are essential in current clinical practice. Myeloma experts are obliged to carefully balance the efficacy and toxicity of drugs for each individual patient. Read More

View Article
September 2018
8 Reads

Rapid Fire: Acute Blast Crisis/Hyperviscosity Syndrome.

Emerg Med Clin North Am 2018 Aug 11;36(3):603-608. Epub 2018 Jun 11.

Department of Emergency Medicine, Wexner Medical Center at The Ohio State University, 760 Prior Hall, 376 West 10th Avenue, Columbus, OH 43210, USA.

Emergency providers are likely to encounter patients with acute and chronic leukemias. In some cases, the first presentation to the emergency department may be for symptoms related to blast crisis and leukostasis. Making a timely diagnosis and consulting a hematologist can be life saving. Read More

View Article
August 2018
3 Reads

[CME: Multiple Myeloma - a Review].

Praxis (Bern 1994) 2018 Jul;107(14):749-754

1 Universitätsspital, Klinik für Innere Medizin, Basel.

CME: Multiple Myeloma - a Review Abstract. Multiple myeloma accounts for 1 % of all malignancies, and its incidence increases with age. Both the symptoms and the course of the disease are heterogeneous. Read More

View Article
July 2018
2 Reads

Cardiopulmonary Bypass in the Setting of Waldenström's Macroglobulinemia.

J Extra Corpor Technol 2018 06;50(2):120-123

School of Cardiovascular Perfusion, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Waldenström's Macroglobulinemia (WM) is a rare lymphoma caused by the overproduction of immunoglobulin M (IgM). The elevated level of IgM causes serum hyperviscosity, cold agglutinins, and cryoglobulinemia. Anemia is also present because of impaired production of erythrocytes. Read More

View Article
June 2018
2 Reads

Idelalisib in a patient with refractory Waldenström's macroglobulinemia complicated by anuric renal failure: a case report.

J Med Case Rep 2018 Jun 12;12(1):164. Epub 2018 Jun 12.

Hematology Department, University Hospital of Nancy, 1, allée du Morvan, 54511, Vandoeuvre Cedex, France.

Background: Waldenström's macroglobulinemia is a rare B-cell lymphoma. The gold standard treatment for Waldenström's macroglobulinemia is an anti-CD20 antibody (rituximab) in combination with alkylating agents and dexamethasone. Treatment targeting the B-cell receptor such as ibrutinib (but not idelalisib) is currently approved for treatment of patients with relapsed or refractory Waldenström's macroglobulinemia. Read More

View Article
June 2018
2 Reads

Anuran amphibians as comparative models for understanding extreme dehydration tolerance: a unique negative feedback lymphatic mechanism for blood volume regulation.

Am J Physiol Regul Integr Comp Physiol 2018 Oct 6;315(4):R790-R798. Epub 2018 Jun 6.

Department of Biology, Portland State University , Portland, Oregon.

Anurans are the most terrestrial order of amphibians. Couple the high driving forces for evaporative loss in terrestrial environments and their low resistance to evaporation, dehydration is an inevitable stress on their water balance. Anurans have the greatest tolerances for dehydration of any vertebrate group. Read More

View Article
October 2018
6 Reads

Use of intravenous iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension.

Int J Cardiol 2018 Sep 19;267:79-83. Epub 2018 May 19.

Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College School of Medicine, London, UK. Electronic address:

Background: Secondary erythrocytosis is common in patients with cyanosis secondary to congenital heart disease (CHD) and/or pulmonary hypertension (PH). This compensatory mechanism aims at increasing oxygen delivery to the tissues, but it requires adequate iron stores. Optimal methods of iron supplementation in this setting remain controversial, with fears of excessive erythropoiesis and hyperviscosity symptoms. Read More

View Article
September 2018
3 Reads

MR imaging findings in some rare neurological complications of paediatric cancer.

Insights Imaging 2018 May 15. Epub 2018 May 15.

Department of Radiology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Read More

View Article
May 2018
1 Read

Blood hyperviscosity identification with reflective spectroscopy of tongue tip based on principal component analysis combining artificial neural network.

Biomed Eng Online 2018 May 10;17(1):60. Epub 2018 May 10.

Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences, Beijing, 100101, China.

Background: With spectral methods, noninvasive determination of blood hyperviscosity in vivo is very potential and meaningful in clinical diagnosis. In this study, 67 male subjects (41 health, and 26 hyperviscosity according to blood sample analysis results) participate.

Methods: Reflectance spectra of subjects' tongue tips is measured, and a classification method bases on principal component analysis combined with artificial neural network model is built to identify hyperviscosity. Read More

View Article
May 2018
4 Reads

Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats.

Microvasc Res 2018 Sep 6;119:91-97. Epub 2018 May 6.

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Background: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms.

Objective: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied.

Methods: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i. Read More

View Article
September 2018
4 Reads

Effects of ex vivo aging and storage temperature on blood viscosity.

Clin Hemorheol Microcirc 2018 ;70(2):155-172

Center for Molecular and Engineering Thermodynamics and Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.

Background: Research on hemorheology is driven in part by its significance in blood diseases and the possible use of hemorheology as a diagnostic tool. However, existing data on blood rheology are limited largely to measurements of steady shear behavior often with varying measurement protocols and insufficient characterization of the physiology.

Objective: The effects of ex vivo aging and environmental conditions on blood viscosity are investigated to improve standards for hemorheology measurements. Read More

View Article
January 2018
2 Reads

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

Clin Hemorheol Microcirc 2018 ;70(1):95-105

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

Background: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable sickled RBCs. Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion and other SCD pathophysiology. GBT440 (generic name voxelotor) is a novel anti-polymerization and anti-sickling agent currently undergoing clinical evaluation for the treatment of SCD. Read More

View Article
November 2018
3 Reads

Increased plasma viscosity in plasma cell dyscrasia and whole blood viscosity in polycythemia vera.

Clin Hemorheol Microcirc 2018 ;70(1):59-67

Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background: Although hyperviscosity syndrome in plasma cell dyscrasia (PCD) and thrombosis in myeloproliferative neoplasm (MPN) are major causes of morbidity and mortality, blood viscosity measurements are often underutilized.

Objective: This study aimed to characterize whether whole blood viscosity (WBV) or plasma viscosity (PV) could be predictive of hyperviscosity syndrome in PCD and could be elevated in subgroups of MPN.

Methods: A total of 75 patients with hematologic diseases: PCD (n = 26), MPN (n = 25) including polycythemia vera (P. Read More

View Article
November 2018
7 Reads

Fifty-Year Incidence of Waldenström Macroglobulinemia in Olmsted County, Minnesota, From 1961 Through 2010: A Population-Based Study With Complete Case Capture and Hematopathologic Review.

Mayo Clin Proc 2018 Jun 12;93(6):739-746. Epub 2018 Apr 12.

Division of Hematology, Mayo Clinic, Rochester, MN.

Objective: To determine the incidence of Waldenström macroglobulinemia (WM) in a strictly defined geographic area over a 50-year period.

Patients And Methods: All residents of Olmsted County with a diagnosis of WM, consisting of a monoclonal IgM protein of any size and/or 10% or more lymphoplasmacytic infiltration of the bone marrow along with anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly requiring therapy, were identified from January 1, 1961, to December 31, 2010. Patients with smoldering WM, lymphoplasmacytic lymphoma with an IgG or IgA monoclonal protein, and those with an IgM monoclonal gammopathy of undetermined significance were excluded. Read More

View Article
June 2018
3 Reads

Caffeine to prevent respiratory failure and improve outcome in infant pertussis.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Randall Children's Hospital, Legacy Emanuel Medical Center, Portland, Oregon, USA.

Pertussis remains a dangerous disease for children around the world, especially for infants less than 6 months old. In this age group, high mortality and morbidity have been linked to the effects of the pertussis toxin, including lymphocytosis, pulmonary hyperviscosity and pulmonary hypertension. This paper reports on an infant with pertussis who received therapeutic caffeine. Read More

View Article
March 2018
3 Reads

Blood Is Thicker: Hyperviscosity Syndrome.

Am J Med 2018 Aug 22;131(8):916-917. Epub 2018 Mar 22.

Department of Medicine, University of California, San Francisco; Department of Medicine, Medical Service, VA Medical Center, San Francisco, Calif.

View Article
August 2018
6 Reads

Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria.

Am J Reprod Immunol 2018 Jun 3;79(6):e12838. Epub 2018 Mar 3.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto (I3S), Porto, Portugal.

Problem: Sexually transmitted diseases and other infections of male genitourinary tract are thought to negatively impact reproductive health, affecting semen quality. Despite a possible link between bacteria and infertility, few studies attempted to characterize seminal microbiota in healthy and diseased subjects.

Methods Of The Study: A high-throughput sequencing of 16S ribosomal RNA gene was performed in a cohort of infertility-related cases (N = 89) and controls (N = 29) using a pooled sample approach. Read More

View Article
June 2018
6 Reads

Therapeutic plasma exchange for hyperviscosity syndrome secondary to high rheumatoid factor.

Transfus Apher Sci 2018 Apr 15;57(2):225-227. Epub 2018 Feb 15.

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, United States.

Hyperviscosity syndrome (HVS) is most commonly associated with Waldenstrom's macroglobulinemia, where it may be life-threatening. HVS may also occur in autoimmune diseases; data pertaining to efficacy of therapeutic plasma exchange (TPE) in HVS arising in non-malignant gammopathy are limited. We report a case of 71-year-old female with erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal <35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis and plasma viscosity (8. Read More

View Article
April 2018
6 Reads

The use of emergency apheresis in the management of plasma cell disorders.

Transfus Apher Sci 2018 Feb 20;57(1):35-39. Epub 2018 Feb 20.

Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Division of Hematology, Therapeutic Apheresis Unit and Blood Bank, Istanbul, Turkey. Electronic address:

Hyperviscosity syndrome (HVS) develops most commonly in Waldenström's macroglobulinemia (WM) and multiple myeloma (MM). Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The most commonly used replacement fluid is 4%-5% human albumin in physiologic saline. Read More

View Article
February 2018
11 Reads

Hyperviscosity syndrome.

Intensive Care Med 2018 07 23;44(7):1151-1152. Epub 2018 Feb 23.

Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, 75012, France.

View Article
July 2018
3 Reads

Treatment of semen samples with α-chymotrypsin alters the expression pattern of sperm functional proteins-a pilot study.

Andrology 2018 03 6;6(2):345-350. Epub 2018 Feb 6.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Semen hyperviscosity delays the liquefaction of semen sample and is subjected to limited proteolysis by addition of α-chymotrypsin to reduce the viscosity. α-Chymotrypsin is a proteolytic enzyme involved in degradation of the proteins and polypeptides. Even though α-chymotrypsin improves the handling of hyperviscous samples, its effect on the sperm proteins is not clear. Read More

View Article
March 2018
5 Reads

Blood rheology of angina pectoris patients with myocardial injury after ischemia reperfusion and its effect on thromboxane B levels.

Exp Ther Med 2018 Jan 6;15(1):769-772. Epub 2017 Nov 6.

Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B (TXB) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure. Read More

View Article
January 2018
2 Reads

Intensely Pruritic Papules and Plaques in Waldenstrom's Macroglobulinemia.

Ann Dermatol 2018 Feb 26;30(1):87-90. Epub 2017 Dec 26.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Waldenstrom's macroglobulinemia (WM) is lymphoplasmacytoid malignancy that affects B lymphocytes. Cutaneous involvement of WM is rare, but various cutaneous manifestations have been reported. These findings are due to various pathological processes including direct invasion of tumor cells into the skin, deposition of paraproteins, hyperviscosity syndrome, and cryoglobulinemia. Read More

View Article
February 2018
4 Reads

Waldenstrom's Macroglobulinemia: A Report of Two Cases, One with Severe Retinopathy and One with Renal Failure.

Case Rep Hematol 2017 31;2017:3732902. Epub 2017 Oct 31.

Division of Hematology, Takasago-seibu Hospital, Takasago 676-0812, Japan.

We report here two cases of Waldenstrom's macroglobulinemia (WM), one with central nervous system (CNS) symptoms and severe retinopathy and one with renal failure. In both cases, the serum IgM levels exceeded 3,000 mg/dL and monoclonal IgM-kappa was observed in the blood. At onset, Case 1, a 63-year-old female, developed CNS symptoms-namely, drowsiness and syncope. Read More

View Article
October 2017
11 Reads

A clinical picture of pulmonary embolism revealing light-chain myeloma.

Clin Case Rep 2017 12 2;5(12):2044-2046. Epub 2017 Nov 2.

Department of Clinical Biochemistry and Toxicology Faculty of Medicine and Pharmacy Mohammed V Military Teaching Hospital Mohammed V University Rabat Morocco.

We are highlighting on the particularity of a clinical picture of pulmonary embolism revealing light-chain myeloma in a 56-year-old male patient. Myeloma remains a rare affection. Even though its revelation through pulmonary embolism remains rare, it can be explained by hyperviscosity syndrome accompanying it. Read More

View Article
December 2017
7 Reads

Erythrocyte Membrane Fluidity Alterations in Sudden Sensorineural Hearing Loss Patients: The Role of Oxidative Stress.

Thromb Haemost 2017 12 6;117(12):2334-2345. Epub 2017 Dec 6.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.

Introduction Sudden sensorineural hearing loss (SSNHL) involves an acute unexplained hearing loss, nearly always unilateral, that occurs over less than a 72-hour period. SSNHL pathogenesis is not yet fully understood. Cochlear vascular occlusion has been proposed as a potential mechanism of hearing damage and cochlear ischaemia has been related to alterations of cochlear microvessels. Read More

View Article
December 2017
11 Reads

A Case of Advanced Glaucoma with Increased Episcleral Venous Pressure in a 17-Year-Old with Eisenmenger Syndrome.

Case Rep Ophthalmol Med 2017 23;2017:5808047. Epub 2017 Oct 23.

Mater Dei Hospital, Msida, Malta.

Eisenmenger syndrome refers to reversal of shunt and central cyanosis due to pulmonary hypertension induced by congenital heart disease with a large systemic-to-pulmonary shunt. We report a case of a 17-year-old man with Eisenmenger syndrome who presented with gradual deterioration in visual acuity and was diagnosed with advanced secondary open angle glaucoma. There have been reports of patients suffering from thrombosis due to hyperviscosity associated with this syndrome; however, to our knowledge, the association of secondary open angle glaucoma with Eisenmenger syndrome has not yet been documented. Read More

View Article
October 2017
12 Reads

Multiple Myeloma Presenting as Acute Renal Failure in the Absence of Other Characteristic Features.

Cureus 2017 Sep 20;9(9):e1703. Epub 2017 Sep 20.

Hematology and Oncology, University of Arizona Cancer Center.

This case report describes a 54-year-old, asymptomatic man who presented with hyperkalemia on routine lab testing who was later found to have acute renal failure, unresponsive to fluid resuscitation, with minimal improvement after hemodialysis. After a comprehensive evaluation ruled out common causes of acute renal failure, the patient underwent testing with a bone survey, urine protein electrophoresis (UPEP), serum protein electrophoresis (SPEP), and immunoelectrophoresis for suspected plasma cell dyscrasia and received plasmapheresis for hyperviscosity syndrome and nephrotoxicity, which resulted in improved renal function. Lab results showed monoclonal gammopathy, elevated serum free light chains, and Bence Jones protein in the urine with a follow-up bone marrow biopsy indicating plasma cell dyscrasia. Read More

View Article
September 2017
8 Reads