Hypertension 2021 Mar 25;77(3):1001-1009. Epub 2021 Jan 25.
Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (A.W., J.C., V.N., E.C.S., E.M.G., S.P., L.E.O., B.K.B., I.B., A.G.), Vanderbilt University Medical Center, Nashville, TN.
The purpose of this study is to evaluate endothelial function in postural tachycardia syndrome (PoTS), a poorly understood chronic condition characterized by a state of consistent orthostatic tachycardia (delta heart rate ≥30 beats per minute) upon standing without orthostatic hypotension. Nineteen patients with PoTS and 9 healthy controls were studied after 3 days of a fixed, caffeine-free, normal sodium (150 milliequivalents/day) diet. All participants underwent autonomic function testing, including sinus arrhythmia, valsalva maneuver, hyperventilation, cold pressor, handgrip, and a standing test with catecholamine measurements, followed by endothelial function testing. Read More