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    The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women.
    Climacteric 2017 Sep 22:1-6. Epub 2017 Sep 22.
    a Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology , Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
    Objective: The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women.

    Methods: A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level >5. Read More

    Uric acid contributes greatly to hepatic antioxidant capacity besides protein.
    Physiol Res 2017 Sep 22. Epub 2017 Sep 22.
    Department of Health and Sports Science, Nippon Medical School, Musashino, Tokyo, Japan.
    Uric acid is the end-product of purine nucleotide metabolism and an increase in uric acid concentration in the body results in hyperuricemia, ultimately leading to gout. However, uric acid is a potent antioxidant and interacts with reactive oxygen species (ROS) to be non-enzymatically converted to allantoin. Uric acid accounts for approximately 60% of antioxidant capacity in the plasma; however, its contribution to tissue antioxidant capacity is unknown. Read More

    Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity.
    Int J Cardiol 2017 Sep 14. Epub 2017 Sep 14.
    Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
    Introduction: Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations.

    Aim: Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS).

    Methods: This was a single-center case-control study. Read More

    Uric Acid for Cardiovascular Risk: Dr. Jekyll or Mr. Hide?
    Diseases 2016 Feb 26;4(1). Epub 2016 Feb 26.
    Fondazione CNR-Regione Toscana G Monasterio and Istituto di Fisiologia Clinica, Italian National Research Council, Pisa I-56124, Italy.
    Uric acid (UA) is a potent endogenous antioxidant. However, high concentrations of this molecule have been associated with cardiovascular disease (CVD) and renal dysfunction, involving mechanisms that include oxidative stress, inflammatory processes, and endothelial injury. Experimental and in vitro results suggest that this biomarker behaves like other antioxidants, which can shift from the physiological antioxidant action to a pro-oxidizing effect according to their level and to microenvironment conditions. Read More

    A phase 1 study of the Janus kinase 2 (JAK2)(V617F) inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.
    Leuk Res 2017 Aug 31;61:89-95. Epub 2017 Aug 31.
    University of Utah School of Medicine, Division of Hematology, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address:
    Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2(V617F) mutation. The study had a standard 3+3 dose-escalation design to define the maximum-tolerated dose. Read More

    [Simultaneous determination of 8 main compounds in Eclipta Herba by UPLC].
    Zhongguo Zhong Yao Za Zhi 2016 Nov;41(21):3982-3987
    Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
    To establish an UPLC method for the simultaneous determination of 8 compounds in Eclipta Herba, such as isoquercitrin, luteoloside, demethylwedelolactone, isochlorogenic acid A, isochlorogenic acid C, luteolin, wedelolactone and apigenin. The experiment was performed with a Waters Acquity UPLC BEH C₁₈ (2.1 mm×100 mm, 1. Read More

    [Virtual screening for components in Chicory combined with CNT2 target based on molecular docking].
    Zhongguo Zhong Yao Za Zhi 2016 Nov;41(21):3962-3967
    School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
    To virtual screen the compound of Chicory combined with the concentrative nucleoside transporter 2 (CNT2) in molecular docking technology.The homology model of hCNT2 was produced, and then the Vina software was employed to virtual screen the Chicory compound combined with CNT2. Compared with 7,8,3'-trihydroxyflavone, a CNT2 inhibitors, 23 score higher chicory compounds were hit. Read More

    Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models.
    Biomed Res Int 2017 27;2017:5852076. Epub 2017 Aug 27.
    School of Life Sciences, Jilin University, Changchun 130012, China.
    This study was performed to investigate the therapeutic effects and possible mechanisms of sunflower (Helianthus annuus) head extract (SHE) on gout. First, the components of sunflower head powder and SHE were analyzed systematically. SHE, especially SHEB (extracted with 20% ethanol and 80% double-distilled water), strongly suppressed the swelling of the ankles in rats with acute gout induced by monosodium urate (MSU) crystals and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia induced by oteracil potassium and yeast extract powder. Read More

    The role of hyperuricemia on vascular endothelium dysfunction.
    Biomed Rep 2017 Oct 9;7(4):325-330. Epub 2017 Aug 9.
    Xianning Central Hospital, Xianning, Hubei 437100, P.R. China.
    Hyperuricemia appears to be associated with an increased risk for cardiovascular disease and associated mortality. Population epidemiological data support a causal link between hyperuricemia and cardiovascular disease. Endothelium injury could be one of the potential mechanisms in hyperuricemia-induced cardiovascular disease. Read More

    Augmented Association Between Blood Pressure and Proteinuria in Hyperuricemic Patients with Non-Nephrotic Chronic Kidney Disease.
    Am J Hypertens 2017 Sep 13. Epub 2017 Sep 13.
    Dialysis Unit, University Hospital of the Ryukyus.
    Background: Hyperuricemia (HU) may enhance susceptibility to hypertensive renal damage via disrupted autoregulation of glomerular hemodynamics. The effect of HU on the association between blood pressure (BP) and proteinuria remains unknown in patients with chronic kidney disease (CKD).

    Methods: In total, 109 patients with non-nephrotic CKD (55 men and 54 females) who underwent renal biopsy were recruited. Read More

    "Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study.
    Obesity (Silver Spring) 2017 Sep 18. Epub 2017 Sep 18.
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
    Objective: Whether obesity without metabolic syndrome (i.e., "metabolically healthy" obesity) confers similar or less metabolic risk remains controversial. Read More

    Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.
    Eur J Med Chem 2017 Aug 24;140:20-30. Epub 2017 Aug 24.
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, PR China. Electronic address:
    A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also presented. Approximately half of the target compounds exhibited the inhibitory potency for XOR at the nanomolar level. Compounds 16c, 16d, and 16f emerged as the most potent xanthine oxidoreductase inhibitors with IC50 values of 5. Read More

    The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1-3.
    Oncotarget 2017 Aug 6;8(34):57099-57108. Epub 2017 Jul 6.
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    There is a high prevalence of hyperuricemia (HUA) in the chronic kidney disease (CKD) population. However, there's a dearth of research on HUA's prevalence, subtypes, early detection, and treatment strategies of HUA in lupus nephritis (LN) patients. The aim of this study is to address these knowledge gaps. Read More

    Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study.
    J Food Drug Anal 2017 Jul 3;25(3):597-606. Epub 2016 Aug 3.
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biomedical Informatics, Asia University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address:
    Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders. XOD inhibitors or uricase (catalyzes UA to the more soluble end product) can prevent these chronic diseases. Read More

    Association of serum uric acid level with coronary artery stenosis severity in Korean end-stage renal disease patients.
    Kidney Res Clin Pract 2017 Sep 30;36(3):282-289. Epub 2017 Sep 30.
    Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Background: Hyperuricemia is common in end-stage renal disease (ESRD) patients, and many previous studies have reported the associations between hyperuricemia and adverse cardiovascular outcomes, which are the major cause of death in such patients. We investigated the relationship between serum uric acid level and the severity of coronary stenosis in ESRD patients on maintenance hemodialysis (MHD).

    Methods: Among 721 patients who started MHD treatment, 102 underwent coronary angiographic tests complaining of chest discomfort that was new at initiation of MHD. Read More

    Renoprotective effects of febuxostat compared with allopurinol in patients with hyperuricemia: A systematic review and meta-analysis.
    Kidney Res Clin Pract 2017 Sep 30;36(3):274-281. Epub 2017 Sep 30.
    Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
    Background: Hyperuricemia is reported to be related to rapid progression of renal function in patients with chronic kidney disease (CKD). Allopurinol, a uric acid lowering agent, protects renal progression. However, it is not widely used in patients with CKD because of its serious adverse event. Read More

    Uric acid induces the expression of TNF‑α via the ROS‑MAPK‑NF‑κB signaling pathway in rat vascular smooth muscle cells.
    Mol Med Rep 2017 Aug 31. Epub 2017 Aug 31.
    Department of Pharmacy, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, P.R. China.
    Hyperuricemia and artery atherosclerosis are closely associated and, as a classic inflammatory biomarker, tumor necrosis factor‑α (TNF‑α) has a direct role in atherogenesis. In the present study, it was demonstrated that uric acid was capable of inducing the generation of TNF‑α in vascular smooth muscle cells (VSMCs). The expression levels of proteins were detected using enzyme‑linked immunosorbent assays and western blot analysis. Read More

    Direct-acting antiviral agents against hepatitis C virus and lipid metabolism.
    World J Gastroenterol 2017 Aug;23(31):5645-5649
    Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan.
    Hepatitis C virus (HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response (SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections. Read More

    Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.
    Molecules 2017 Sep 7;22(9). Epub 2017 Sep 7.
    Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan-gun, Jeonnam 58554, Korea.
    Cudrania tricuspidata Bureau (Moraceae) shows numerous pharmacological effects and has been used in traditional herbal remedies for inflammation, gastritis, tumors, and liver diseases. However, no validated analytical method for the standardization and optimization of the biological properties of C. tricuspidata preparations has been reported. Read More

    Treatment of tumor lysis syndrome in children with leukemia/lymphoma in resource-limited settings-Efficacy of a fixed low-dose rasburicase.
    Pediatr Hematol Oncol 2017 Sep 5:1-6. Epub 2017 Sep 5.
    a Department of Pediatric oncology, Regional Cancer Centre , Trivandrum , Kerala , India.
    Rasburicase is a novel drug used during the management of tumor lysis syndrome. In countries with limited resources, it is frequently given at a lower dose and only for the treatment of established tumor lysis syndrome and not as prophylaxis. A retrospective study was conducted in the department of pediatric oncology at a tertiary referral oncology center in south India to analyze the use of rasburicase over the past 3 years. Read More

    Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains.
    Neurosci Lett 2017 Sep 6;659:99-103. Epub 2017 Sep 6.
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan. Electronic address:
    It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease. However, whether there is a system that directly transports urate into the brain remains to be clarified. In this study, the localization of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1), which are known to be representative reabsorptive urate transporters, was immunohistochemically examined in autopsied human brains. Read More

    Hyperuricemia is associated with progression of chronic kidney disease in patients with reduced functioning kidney mass.
    Nefrologia 2017 Aug 30. Epub 2017 Aug 30.
    Hospital General Universitario Gregorio Marañón, Spain.
    Background And Objectives: Hyperuricemia plays a major role in the development and progression of chronic kidney disease (CKD). Many large observational studies have indicated that increased serum uric acid level predicts the development and progression of CKD in some population, however this hypothesis has not been yet studied in patients with reduced renal mass.

    Design, Setting, Participants, & Measurements: Retrospective study with a cohort of 324 patients with reduced renal mass from an outpatient basis, followed during 60 (36-98) months. Read More

    Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies.
    Ann Rheum Dis 2017 Sep 2. Epub 2017 Sep 2.
    The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
    Objectives: Weight loss is commonly recommended for gout, but the magnitude of the effect has not been evaluated in a systematic review. The aim of this systematic review was to determine benefits and harms associated with weight loss in overweight and obese patients with gout.

    Methods: We searched six databases for longitudinal studies, reporting the effect of weight loss in overweight/obese gout patients. Read More

    [Analysis of the Cochrane Review: Pharmacotherapy for Hyperuricemia in Hypertensive Patients. Cochrane Database Syst Rev. 2017;4:CD008652.]
    Acta Med Port 2017 May 31;30(5):356-360. Epub 2017 May 31.
    Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal. Centro Colaborador Português da Rede Cochrane Iberoamericana. Lisboa. Portugal.
    Arterial hypertension is a public health problem that affects approximately 25% of the world's adult population. The association between hypertension and hyperuricemia has been shown on epidemiological and experimental studies. However, it is unclear whether lowering serum uric acid might lower blood pressure. Read More

    Ozonated autohemotherapy modulates the serum levels of inflammatory cytokines in gouty patients.
    Open Access Rheumatol 2017 11;9:159-165. Epub 2017 Aug 11.
    Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
    Objectives: Ozonated autohemotherapy (O3-AHT) has been used to effectively treat gout, but the underlying therapeutic mechanisms remain unknown. In this study, as an initial effort to understand the therapeutic mechanisms of O3-AHT, we aim to examine the effect of O3-AHT on serum inflammatory cytokine levels in gouty patients.

    Patients And Methods: Three groups of patients and healthy subjects were recruited, including the gouty (n=10), hyperuricemia (n=10), and healthy control (n=11) groups. Read More

    Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies.
    Br J Cancer 2017 Aug 31. Epub 2017 Aug 31.
    Early Drug Development Center, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
    Background: Dinaciclib is a potent inhibitor of cell cycle and transcriptional cyclin-dependent kinases. This Phase 1 study evaluated the safety, tolerability and pharmacokinetics of various dosing schedules of dinaciclib in advanced solid tumour patients and assessed Pharmacodynamic and preliminary anti-tumour activity.

    Methods: In part 1, patients were enrolled in escalating cohorts of 2-h infusions administered once every 3 weeks, utilising an accelerated titration design until a recommended phase 2 dose (RP2D) was defined. Read More

    Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.
    J Sep Sci 2017 Aug 30. Epub 2017 Aug 30.
    Clinical Department of Rehabilitation, College of Acupuncture and Massage, Changchun University of Chinese Medicine, Changchun, China.
    Natural products have become one of the most important resources for discovering novel xanthine oxidase inhibitors, which are commonly employed in the treatment of hyperuricemia and gout. However, to date, few reports exist regarding the use of monoterpene glycosides as xanthine oxidase inhibitors. Thus, we herein report the use of ultrafiltration coupled with liquid chromatography in the screening of monoterpene glycoside xanthine oxidase inhibitors from the extract of Paeonia lactiflora (P. Read More

    In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis.
    Mol Med Rep 2017 Oct 9;16(4):4823-4828. Epub 2017 Aug 9.
    Department of Rheumatology and Immunology, Rheumatology Institute, The Fifth Hospital of Xi'an, Xi'an, Shaanxi 710082, P.R. China.
    The super-saturation of serum with monosodium urate due to hyperuricemia is the core metabolic disorder of rheumatoid arthritis. When the serum urate concentration is ≥7 mg/dl, this results in the crystallization of monosodium urate in serum at body temperature (37˚C/98.6˚F). Read More

    Novel Insights in the Metabolic Syndrome in Childhood and Adolescence.
    Horm Res Paediatr 2017 Aug 28. Epub 2017 Aug 28.
    Hospital for Children and Adolescents, Centre for Pediatric Research, Department Woman and Child Health, University of Leipzig, Leipzig, Germany.
    Metabolic syndrome (MetS) is recognized as an escalating major health risk in adults as well as in children and adolescents. Its prevalence ranges from 6 to 39% depending on the applied definition criteria. To date, there is no consensus on a MetS definition for children and adolescents. Read More

    Sex difference in the association of serum uric acid with metabolic syndrome and its components: a cross-sectional study in a Chinese Yi population.
    Postgrad Med 2017 Aug 31:1-6. Epub 2017 Aug 31.
    a School of Public Health , Southwest Medical University , Luzhou , China.
    Objectives: Since the association between serum uric acid (SUA) and metabolic syndrome (MetS) has been reported extensively, it remains unclear whether SUA is associated with MetS and its components in a Chinese Yi population.

    Methods: This study recruited 1,903 people (912 men, 991 women) older than 18 years old from the Liangshan region in Sichuan province. Anthropometric measurements and biochemical indexes were measured by a standard protocol. Read More

    Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials.
    Diabetes Obes Metab 2017 Aug 28. Epub 2017 Aug 28.
    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730.
    To describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM), PubMed, CENTRAL, EMBASE, and were searched for randomized controlled trials of SGLT2 inhibitors in patients with T2DM up to 20 May 2017. Sixty-two studies totaling 34,941 patients were included. Read More

    [Nephrolithiasis coexisting with type 2 diabetes: current concept of the features of stone formation and the effects of hypoglycemic therapy on lithogenesis].
    Urologiia 2017 Jul(3):92-97
    N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of the NMRRC of Minzdrav of Russia, Moscow, Russia.
    The article analyzes Russian and international literature examining specific features of the pathogenesis of renal stones in the setting of carbohydrate metabolism disorders. The authors outline the renal effects of the main pharmacological groups of oral hypoglycemic drugs regarding metaphylaxis of nephrolithiasis. An increased risk of nephrolithiasis in type 2 diabetes mellitus is realized through hyperuricemia with concurrent urine acidification. Read More

    Gout and Metabolic Syndrome: a Tangled Web.
    Curr Rheumatol Rep 2017 Aug 26;19(10):60. Epub 2017 Aug 26.
    Crystal Diseases Study Group, Division of Rheumatology, Department of Medicine, New York University School of Medicine, 301 East 17th Street, Suite 1410, New York, NY, 10003, USA.
    Purpose Of Review: The complexity of gout continues to unravel with each new investigation. Gout sits at the intersection of multiple intrinsically complex processes, and its prevalence, impact on healthcare costs, and association with important co-morbidities make it increasingly relevant. The association between gout and type 2 diabetes, hypertension, hyperlipidemia, cardiovascular disease, renal disease, and obesity suggest that either gout, or its necessary precursor hyperuricemia, may play an important role in the manifestations of the metabolic syndrome. Read More

    Prevalence of hyperuricemia and its related risk factors among preschool children from China.
    Sci Rep 2017 Aug 25;7(1):9448. Epub 2017 Aug 25.
    Tianjin Women and Children's Health Center, Tianjin, China.
    To estimate the prevalence of hyperuricemia and its major risk factors among Chinese preschool children. A cross-sectional survey was carried out in six central urban districts of Tianjin from March to June 2015. A cluster sampling was employed to obtain a random sample of preschool children. Read More

    Effects of Laparoscopic Roux-en-Y Gastric Bypass on Chinese Type 2 Diabetes Mellitus Patients with Different Levels of Obesity: Outcomes After 3 Years' Follow-Up.
    Obes Surg 2017 Aug 24. Epub 2017 Aug 24.
    Department of Gastrointestinal Surgery, Laboratory of Bariatric and Metabolic Surgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, People's Republic of China.
    Background: Laparoscopic Roux-en-Y gastric bypass (LRYGB) has been proven to be effective on treating type 2 diabetes mellitus (T2DM) in severely obese patients, but whether LRYGB surgery should be performed in obese class I patients is controversial.

    Materials And Methods: A retrospective study of 3-year bariatric and metabolic outcomes in different obese class T2DM patients who underwent LRYGB was conducted to compare the effectiveness of LRYGB in obese class I patients with that in obese class II/III patients in a Chinese T2DM population.

    Results: Totally, 58 patients with class I obesity and 45 patients with class II/III obesity were enrolled in this study. Read More

    Coexistence of Sarcoidosis and Gouty Arthritis.
    Reumatol Clin 2017 Aug 21. Epub 2017 Aug 21.
    Istinye University, Faculty of Medicine, Liv Hospital, Department of Rheumatology, Turkey. Electronic address:
    Sarcoidosis is an inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. Gouty arthritis is an autoinflammatory disease characterized by hyperuricemia, recurrent arthritis attacks and the deposition of monosodium urate crystals in the joints and the surrounding tissues. Read More

    [DPP-4 or SGLT2 inhibitor added to metformin alone in type 2 diabetes].
    Rev Med Suisse 2017 Aug;13(571):1410-1415
    Université de Liège, Service de diabétologie, nutrition et maladies métaboliques, CHU Liège, Belgique.
    After failure of a monotherapy with metformin, dipeptidyl peptidase-4 inhibitors (gliptins) and sodium-glucose cotransporters type 2 (gliflozins) offer an alternative to the add-on of a sulphonylurea, especially in diabetic patients at risk of hypoglycaemia. The choice between a gliptin and a gliflozin may be guided by the individual patient characteristics : rather a gliptin in a patient without obesity or severe hyperglycaemia, in an elderly patient, with a frailty profile or with renal impairment; rather a gliflozin in an obese patient, with hypertension, hyperuricaemia, antecedents of cardiovascular disease (especially heart failure), without advanced renal insufficiency and with a low risk of urinary/genital infections or events linked to dehydration such as hypotension. Read More

    Uric acid and incident chronic kidney disease in dyslipidemic individuals.
    Curr Med Res Opin 2017 Sep 21:1-7. Epub 2017 Sep 21.
    a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.
    Background: Elevated uric acid (UA) is a recognized risk factor for chronic kidney disease (CKD). This study aimed to investigate whether this association exists in dyslipidemic patients receiving multifactorial treatment.

    Methods: An observational study conducted in Greece including 1,269 dyslipidemic individuals followed-up in a lipid clinic for ≥3 years. Read More

    Elevated serum uric acid level was a notable adverse event during combination therapy with sofosbuvir and ribavirin.
    Hepatol Res 2017 Aug 19. Epub 2017 Aug 19.
    Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki Hokuse-cho, Inaba, Mie, 511-0406, Japan.
    Aim: Combination therapy with sofosbuvir and ribavirin (SOF/RBV) has been recently available for chronic hepatitis C patients with genotype 2 (CHG2) in Japan. The domestic phase-III clinical trial showed a high antiviral effect with a relatively safe adverse event (AE) profile. Our aim was to report an important AE detected during treatment. Read More

    Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes.
    Sci Rep 2017 Aug 18;7(1):8822. Epub 2017 Aug 18.
    Department of Scientific Research Project, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street Zhongshan District, Dalian, Liaoning Province, 116001, People's Republic of China.
    Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subjects from the China Health and Nutrition Survey 2009 were retained. Read More

    Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension.
    Hypertension 2017 Oct 14;70(4):703-711. Epub 2017 Aug 14.
    From the National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, P. R. China (T.H., R.Q., Q.X., R.J., L.N., C.S.); and Harbin Center for Disease Control and Prevention, P. R. China (L.L.).
    Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Read More

    Prevalence of Hyperuricemia in Patients With Acute Heart Failure With Either Reduced or Preserved Ejection Fraction.
    Am J Cardiol 2017 Oct 17;120(7):1146-1150. Epub 2017 Jul 17.
    Baylor University Medical Center, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas; The Heart Hospital, Plano, Texas.
    The relation between uric acid (UA) and heart failure has been described; however, there is little detail concerning acute heart failure (AHF) in patients with reduced versus preserved ejection fraction heart failure (HFrEF, HFpEF). We studied 324 consecutive AHF patients screened from interventional Diur-HF Trial (NCT01441245) from January 2011 to February 2016, and divided into HFrEF (EF <50%) and HFpEF (EF ≥50%). We defined hyperuricemia as serum UA ≥7. Read More

    Critical revision of the medical treatment of gout in Brazil.
    Rev Bras Reumatol Engl Ed 2017 Jul - Aug;57(4):346-355. Epub 2017 Apr 6.
    Universidade do Estado do Rio de Janeiro, Serviço de Reumatologia, Rio de Janeiro, RJ, Brazil.
    Gout is considered the most common form of inflammatory arthritis in men over 40 years. The authors present a brief review of the current treatment of gout and discuss the existing pharmacological limitations in Brazil for the treatment of this disease. Although allopurinol is still the main drug administered for decreasing serum levels of uric acid in gout patients in this country, the authors also present data that show a great opportunity for the Brazilian drug market for the treatment of hyperuricemia and gout and especially for patients using private and public (SUS) health care systems. Read More

    Impact of Hyperuricemia on Long-term Outcomes of Kidney Transplantation: Analysis of the FAVORIT Study.
    Am J Kidney Dis 2017 Aug 9. Epub 2017 Aug 9.
    Division of Nephrology, Department of Medicine, University of Iowa, Iowa City, IA.
    Background: Elevated uric acid concentration is associated with higher rates of cardiovascular (CV) morbidity and mortality in the general population. It is not known whether hyperuricemia increases the risk for CV death or transplant failure in kidney transplant recipients.

    Study Design: Post hoc cohort analysis of the FAVORIT Study, a randomized controlled trial that examined the effect of homocysteine-lowering vitamins on CV disease in kidney transplantation. Read More

    Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?
    Arthritis Res Ther 2017 Aug 10;19(1):184. Epub 2017 Aug 10.
    Academic Rheumatology, Division of Rheumatology, Orthopaedics, and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.
    The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. Read More

    Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.
    PLoS One 2017 10;12(8):e0181685. Epub 2017 Aug 10.
    Department of Rheumatology & Immunology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China.
    Background: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis. The ATP-P2X7R-IL-1β axis may be one of these pathways. Read More

    Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN).
    Nat Rev Rheumatol 2017 Sep 10;13(9):561-568. Epub 2017 Aug 10.
    VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, California 92161, USA.
    In November 2016, the American College of Physicians (ACP) published a clinical practice guideline on the management of acute and recurrent gout. This guideline differs substantially from the latest guidelines generated by the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR) and 3e (Evidence, Expertise, Exchange) Initiative, despite reviewing largely the same body of evidence. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) convened an expert panel to review the methodology and conclusions of these four sets of guidelines and examine possible reasons for discordance between them. Read More

    Allopurinol Against Progression of Chronic Kidney Disease.
    Iran J Kidney Dis 2017 Jul;11(4):286-293
    Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Introduction: Hyperuricemia is common in approximately 50% of patients with kidney failure due to decreased uric acid excretion, and it has been recently known as an independent factor in the progression of renal insufficiency. Allopurinol inhibits the production of uric acid. The aim of this study was to evaluate the effect of allopurinol on chronic kidney disease progression. Read More

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