8,934 results match your criteria Hyperuricemia


Sex Differences in the Outcomes of Elderly Patients with Acute Coronary Syndrome.

Cardiol Res Pract 2020 12;2020:5091490. Epub 2020 May 12.

Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: The impact of sex on the outcome of patients with acute coronary syndrome (ACS) has been suggested, but little is known about its impact on elderly patients with ACS.

Methods: This study analyzed the impact of sex on in-hospital and 1-year outcomes of elderly (≥75 years of age) patients with ACS hospitalized in our department between January 2013 and December 2017.

Results: A total of 711 patients were included: 273 (38. Read More

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http://dx.doi.org/10.1155/2020/5091490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240792PMC

Albumin affibody-outfitted injectable gel enabling extended release of urate oxidase-albumin conjugates for hyperuricemia treatment.

J Control Release 2020 May 23. Epub 2020 May 23.

School of Chemical Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:

Therapeutic proteins are attractive candidates for the treatment of human diseases. However, their short half-life often limits their clinical application. To overcome this problem, injectable hydrogels have been developed as depots for controlled release of therapeutic proteins, but these systems have not yet achieved the desired extended, sustained drug release profile. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.037DOI Listing

The role of uric acid in inflammasome-mediated kidney injury.

Curr Opin Nephrol Hypertens 2020 May 20. Epub 2020 May 20.

Nephrology Division, Federal University of São Paulo.

Purpose Of Review: Uric acid is produced after purine nucleotide degradation, upon xanthine oxidase catalytic action. In the evolutionary process, humans lost uricase, an enzyme that converts uric acid into allantoin, resulting in increased serum uric acid levels that may vary according to dietary ingestion, pathological conditions, and other factors. Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000619DOI Listing

Cardiovascular risk in patients with new gout diagnosis: is monosodium urate volume at ankles and feet on dual-energy CT associated with previous cardiovascular events?

Clin Exp Rheumatol 2020 May 11. Epub 2020 May 11.

Department of Rheumatology, Medical Center Amersfoort, The Netherlands.

Objectives: Chronic inflammation associated with hyperuricaemia and urate deposition may contribute to an increased risk of developing cardiovascular (CV) events (CVE) in patients with gout. The aim of this study was to explore whether urate deposition on dual-energy CT (DECT) present at the diagnosis of gout is associated with a history of CVE.

Methods: Patients from a study on clinical value of DECT with mono or oligoarthritis who had gout according the 2015 EULAR/ACR classification criteria were included in this cross-sectional study. Read More

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SMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family.

Sci Rep 2020 May 25;10(1):8616. Epub 2020 May 25.

Division of Nephrology, Beijing AnZhen Hospital, Capital Medical University, Beijing, 100029, China.

We reported a large Chinese family diagnosed with autosomal dominant tubulointerstitial kidney disease caused by MUC1 mutation (ADTKD-MUC1). Cytosine duplication within a string of 7 cytosines in the variable-number tandem repeats (VNTR) region of the MUC1 gene was detected by long-read single-molecule real-time (SMRT) sequencing. MUC1 frameshift protein (MUC1fs) was found to be expressed in renal tubules and urinary exfoliated cells by pathological examination. Read More

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http://dx.doi.org/10.1038/s41598-020-65491-2DOI Listing

Madelung's disease and pulmonary aspergillosis: a case report and literature review.

J Cardiothorac Surg 2020 May 25;15(1):114. Epub 2020 May 25.

Department of Thoracic Surgery, Second Affiliated Hospital of Kunming Medical University, 374th Dianmian Road, Kunming, 650101, China.

Background: Madelung's disease (MD) is a rare disorder of fat metabolism, which is usually associated with diabetes, hyperuricemia, liver disease, nevertheless there is no report of a patient with MD and pulmonary aspergillosis (PA). This article aimed to enhance the awareness of this two diseases and discuss the possible mechanism of the combination of them preliminarily.

Case Presentation: In this case, we described a 56-year-old male patient with cough, expectoration and dyspnea. Read More

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http://dx.doi.org/10.1186/s13019-020-01166-3DOI Listing

Incidence and risk of tumor lysis syndrome in patients with relapsed chronic lymphocytic leukemia (CLL) treated with venetoclax in routine clinical practice.

Leuk Lymphoma 2020 May 25:1-6. Epub 2020 May 25.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

The risk of TLS in patients with relapsed CLL treated outside of clinical trials is not well described. Using the Mayo Clinic CLL Database, 48 patients treated with venetoclax for relapsed CLL in routine practice were identified; chart review determined baseline risk for TLS and laboratory abnormalities during venetoclax ramp-up. Overall, 6 (13%) patients developed laboratory TLS, 3 of whom demonstrated clinical TLS. Read More

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http://dx.doi.org/10.1080/10428194.2020.1768384DOI Listing

Kidney involvement and associated risk factors in children with Duchenne muscular dystrophy.

Pediatr Nephrol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics, Division of Pediatric Nephrology, Antalya Training and Research Hospital, 07059, Antalya, Turkey.

Background: Kidney dysfunction is a common complication in adults with Duchenne muscular dystrophy (DMD); however, little attention has been paid to kidney function in pediatric patients.

Methods: Medical records of patients with DMD who were followed up for ≥ 12 months were retrospectively reviewed. Inclusion criteria were (i) aged 5-18 years, (ii) proven mutations in the dystrophin gene, and (iii) absence of structural anomalies of the kidney and urinary tract. Read More

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http://dx.doi.org/10.1007/s00467-020-04587-3DOI Listing

Management of gout by Moroccan rheumatologists: a Moroccan Society for Rheumatology National Survey.

Rheumatol Int 2020 May 23. Epub 2020 May 23.

Department of Rheumatology B, El Ayachi Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.

To assess the modalities and current practices in gout management reported by Moroccan rheumatologists. We performed a cross-sectional online survey using a questionnaire e-mailed to 360 rheumatologists included 30 multiple-choice questions. 105 rheumatologists responded to the survey with 29% of response rate. Read More

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http://dx.doi.org/10.1007/s00296-020-04599-0DOI Listing

Prevalence of hyperuricaemia in an Eastern Chinese population: a cross-sectional study.

BMJ Open 2020 May 20;10(5):e035614. Epub 2020 May 20.

Department of Endocrinology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

Objectives: In the past decade, China has been characterised by large-scale urbanisation as well as rapid economic growth. The aim of this study was to further investigate the prevalence of hyperuricaemia (HUA) in an Eastern Chinese population.

Design: Cross-sectional study. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035614DOI Listing

Association between retinol intake and hyperuricaemia in adults.

Public Health Nutr 2020 May 21:1-10. Epub 2020 May 21.

Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, People's Republic of China.

Objective: Current evidences on the association between hyperuricaemia and retinol intake remain inconsistent. Furthermore, no known studies have investigated the relationship between hyperuricaemia and retinol intake from animal food and plant food separately. This study aimed to assess the relationship between different sources of retinol intake and risk of hyperuricaemia among US adults. Read More

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http://dx.doi.org/10.1017/S1368980020000324DOI Listing

Impact of plasma xanthine oxidoreductase activity in patients with heart failure with preserved ejection fraction.

ESC Heart Fail 2020 May 20. Epub 2020 May 20.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.

Aims: Reactive oxygen species are reportedly involved in the mechanism underlying heart failure with preserved ejection fraction (HFpEF); however, the disease pathophysiology remains poorly understood. Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species. However, the impact of plasma XOR activity on the clinical outcomes of patients with HFpEF remains unclear. Read More

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http://dx.doi.org/10.1002/ehf2.12734DOI Listing

Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia.

Heart Vessels 2020 May 19. Epub 2020 May 19.

Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639 Zhizaoju road, Shanghai, 200011, People's Republic of China.

Both hypertension and hyperuricemia are closely associated with the morbidity and mortality of heart failure. This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-onset heart failure with preserved ejection fraction (HFpEF) in these patients. Using a propensity score matching of 1:2 ratio, this retrospective claims database study compared febuxosatat prescription (n = 96) and non-urate-lowering therapy (n = 192) in patients with hypertensive left ventricular hypertrophy (LVH) and asymptomatic hyperuricemia. Read More

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http://dx.doi.org/10.1007/s00380-020-01619-8DOI Listing

Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease.

Proc Natl Acad Sci U S A 2020 May 19. Epub 2020 May 19.

Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322.

Lesch-Nyhan disease (LND), caused by a deficient salvage purine pathway, is characterized by severe neurological manifestations and uric acid overproduction. However, uric acid is not responsible for brain dysfunction, and it has been suggested that purine nucleotide depletion, or accumulation of other toxic purine intermediates, could be more relevant. Here we show that purine alterations in LND fibroblasts depend on the level of folic acid in the culture media. Read More

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http://dx.doi.org/10.1073/pnas.2003475117DOI Listing

Takotsubo syndrome and cancer, clinical and prognostic implications, insights of RETAKO.

Med Clin (Barc) 2020 May 16. Epub 2020 May 16.

Servicio de Cardiología, Hospital Joan XXIII, Tarragona, España.

Background And Objectives: A relationship between neoplasms and Takotsubo syndrome (TS) has been postulated. Our goal was to determine its prevalence in patients with TS, compare the clinical profile of TS with or without cancer and study its long-term evolution.

Materials And Methods: The oncological situation of patients included in the National Registry on TAKOtsubo syndrome (RETAKO), admitted between 2002 and 2019, provided by 38 hospitals throughout the country is analysed. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.01.033DOI Listing

Uric acid and kidney damage in systemic lupus erythematosus.

Clin Chim Acta 2020 May 16. Epub 2020 May 16.

Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs; lupus nephritis (LN) is one of the most severe complications of SLE. In the kidneys, an intense inflammatory reaction affects the glomeruli and tubular interstitium. Uric acid has been considered a key molecule in the pathogenesis of some conditions such as metabolic syndrome, hypertension, and kidney disease as it is produced by injured cells and promotes immune-inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.034DOI Listing

Longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease in hypertensive and normotensive adults.

Blood Press 2020 May 19:1-11. Epub 2020 May 19.

Center for Cardiovascular Prevention, First Faculty of Medicine and Thomayer Hospital, Charles University in Prague, Prague, Czech Republic.

To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT). Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population random sample of the general population of nine districts of the Czech Republic aged 25-64 years, stratified by age and gender. Hyperuricaemia was defined as serum uric acid ≥ 420 μmol/l in men, and ≥ 360 μmol/l in women. Read More

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http://dx.doi.org/10.1080/08037051.2020.1763158DOI Listing

Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan.

Nutrients 2020 May 14;12(5). Epub 2020 May 14.

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

The potential contribution of serum osmolarity in the modulation of blood pressure has not been evaluated. This study was done to examine the relationship between hyperosmolarity and hypertension in a five-year longitudinal design. We enrolled 10,157 normotensive subjects without diabetes who developed hypertension subsequently as determined by annual medical examination in St. Read More

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http://dx.doi.org/10.3390/nu12051422DOI Listing

Effect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled Trial.

J Diet Suppl 2020 May 18:1-13. Epub 2020 May 18.

Rheumatic Disease Unit, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

Hyperuricemia leads to gout and renal complications and may increase cardiovascular risk. Curcumin inhibits xanthine oxidase and increases uricosuric activity and, as a result, decreases serum urate (SU). This randomized controlled trial aimed to determine the effects of curcumin versus placebo on SU in subjects with asymptomatic hyperuricemia (SU level ≥ 6 mg/dL in women or ≥ 7 mg/dL in men). Read More

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http://dx.doi.org/10.1080/19390211.2020.1757798DOI Listing

Comparative effect of allopurinol and febuxostat on long-term renal outcomes in patients with hyperuricemia and chronic kidney disease: a systematic review.

Clin Rheumatol 2020 May 16. Epub 2020 May 16.

Durham Veterans Affairs Health Care System, Pharmacy Department, Durham, NC, 27705, USA.

Patients with chronic kidney disease (CKD) are more likely to develop hyperuricemia and gout. Allopurinol and febuxostat are the most commonly used urate-lowering therapies with established safety and efficacy in CKD patients. The objective of the systematic review is to assess the long-term renal outcomes of allopurinol compared with febuxostat in patients with hyperuricemia and CKD or kidney transplantation. Read More

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http://dx.doi.org/10.1007/s10067-020-05079-3DOI Listing

Elevated Uric Acid Prevalence and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from RELAX.

Am J Med 2020 May 13. Epub 2020 May 13.

Division of Cardiology, Department of Medicine, Duke University Hospital, Durham, NC 27710; Duke Clinical Research Institute, Durham, NC 27701.

Purpose: We aimed to 1) describe characteristics of patients with heart failure with preserved ejection fraction (HFpEF) enrolled in RELAX stratified by normal or elevated baseline serum uric acid (sUA) level, 2) evaluate the association between sUA level and surrogate clinical measures, and 3) assess associations between changes in sUA level over time and changes in surrogate clinical measures.

Methods: We analyzed 212 patients with HFpEF and normal or elevated (>6 mg/dL) baseline sUA measurements from the RELAX trial. Variables examined included clinical characteristics, cardiopulmonary exercise (CPX) testing, 6-minute walk testing (6MWT), quality of life, echocardiography, and serum biomarker testing. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.03.054DOI Listing

Over 20-Year Follow-up of Patients with Hepatic Glycogen Storage Diseases: Single-Center Experience.

Diagnostics (Basel) 2020 May 13;10(5). Epub 2020 May 13.

Department of Pediatrics, Nutrition and Metabolic Diseases, Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Background: The published data on the long-term outcomes of glycogen storage disease (GSD) patients is sparse in the literature. The aim of this study was to analyze the long-term (over 20 years) follow-up of patients with hepatic types of GSD-I, III, VI, and IX-from childhood to adulthood, managed by one referral center.

Patients And Methods: Thirty adult patients with hepatic GSD were included in the study. Read More

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http://dx.doi.org/10.3390/diagnostics10050297DOI Listing

Efficacy and safety of urate-lowering treatments in patients with hyperuricemia: A comprehensive network meta-analysis of randomized controlled trials.

J Clin Pharm Ther 2020 May 13. Epub 2020 May 13.

Department of Pharmacy, The First Hospital of China Medical University, Shenyang, Liaoning Province, PR China.

What Is Known And Objective: Hyperuricemia (HUA) and gout are considerable public health problems because of their increasing incidence and interactions with other diseases. We aimed to evaluate the efficacy and safety of urate-lowering therapies (ULTs) for patients.

Methods: A systematic literature review was conducted, and a network meta-analysis was performed on the included studies using the Markov Chain Monte Carlo simulation method and a Bayesian statistical framework. Read More

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http://dx.doi.org/10.1111/jcpt.13156DOI Listing

A review of the safety of favipiravir - a potential treatment in the COVID-19 pandemic?

J Virus Erad 2020 Apr 30;6(2):45-51. Epub 2020 Apr 30.

MetaVirology LTD, London, UK.

Background: Repurposing broad-spectrum antivirals is an immediate treatment opportunity for 2019 coronavirus disease (COVID-19). Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. We aim to review existing favipiravir safety evidence, which is vital to informing the potential future use of favipiravir in COVID-19. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213073PMC

SGLT2 Inhibitors: the Star in the Treatment of Type 2 Diabetes?

Authors:
Yoshifumi Saisho

Diseases 2020 May 11;8(2). Epub 2020 May 11.

Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan.

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral hypoglycemic agents which increase urinary glucose excretion by suppressing glucose reabsorption at the proximal tubule in the kidney. SGLT2 inhibitors lower glycated hemoglobin (HbA1c) by 0.6-0. Read More

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http://dx.doi.org/10.3390/diseases8020014DOI Listing

Serum uric acid is independently associated with aortic arch calcification in a cross-sectional study of middle-aged and elderly women.

Nutr Metab Cardiovasc Dis 2020 Mar 3. Epub 2020 Mar 3.

Division of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, China. Electronic address:

Background And Aims: The increased serum uric acid (SUA) level is associated with the prevalence of cardiovascular disease (CVD) risks. Aortic arch calcification (AAC) reflects subclinical coronary atherosclerosis and is linked to subsequent cardiovascular morbidity and mortality risks closely. To better understand the role of SUA on arteriosclerosis and CVD, we aim to determine the association between SUA and the presence of AAC. Read More

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http://dx.doi.org/10.1016/j.numecd.2020.02.015DOI Listing

A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients.

Ren Fail 2020 Nov;42(1):447-454

Nephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

Hyperuricemia occurs frequently in patients with continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the impact of serum uric acid (UA) over time on residual renal function (RRF) loss in a cohort of patients with CAPD. A total of 201 patients who started CAPD therapy between January 1, 2008 and April 30, 2016 were included in this single-center, retrospective cohort study. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1761387DOI Listing
November 2020

Association of anti-hyperuricemia treatment and prevalent cardiovascular disease in hypertensive patients.

Arch Med Sci 2020 11;16(3):545-550. Epub 2019 Apr 11.

Department of Cardiology, FuWai Hospital Chinese Academic of Medical Science, Shenzhen, Guangdong, China.

Introduction: The current study aimed to evaluate the association of anti-hyperuricemia treatment and prevalent cardiovascular disease (CVD) in hypertensive patients.

Material And Methods: Primary hypertensive patients with hyperuricemia were enrolled. All participants were separated into two groups: anti-hyperuricemia and control groups (without anti-hyperuricemia treatment). Read More

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http://dx.doi.org/10.5114/aoms.2019.84397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212227PMC

Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis.

Clin Nutr Res 2020 Apr 27;9(2):122-133. Epub 2020 Apr 27.

Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931851147, Iran.

High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2-6, 7-10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc. Read More

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http://dx.doi.org/10.7762/cnr.2020.9.2.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192665PMC

Sex-specific differences in the prevalence of and risk factors for hyperuricemia among a low-income population in China: a cross-sectional study.

Postgrad Med 2020 May 12:1-9. Epub 2020 May 12.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

: China has already entered the aging society, and its aging population is the largest worldwide. Accordingly, several aging-related conditions including hyperuricemia are becoming a public health concern owing to their increasing prevalence in rural areas. However, the sex-specific differences in the risk factors for hyperuricemia among the middle-aged and elderly in rural North China are unclear. Read More

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http://dx.doi.org/10.1080/00325481.2020.1761133DOI Listing

Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout.

Am J Cardiol 2020 Apr 22. Epub 2020 Apr 22.

Division of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.

Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke University Health System to describe characteristics of patients with HFpEF and hyperuricemia (serum uric acid >6 mg/dl) or gout (gout diagnosis or gout medication within the previous year) and to explore associations with 5-year outcomes (death and hospitalization). Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.026DOI Listing

Arterial hypertension associated with hyperuricemia: features of heart damage.

Wiad Lek 2020 ;73(5):943-946

Internal Medicine Department, Medical Institute, Sumy State University, Sumy, Ukraine.

Objective: The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension.

Patients And Methods: Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) - arterial hypertension. Read More

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January 2020

Risk factors for progression of ossification of the posterior longitudinal ligament in asymptomatic subjects.

J Neurosurg Spine 2020 May 8:1-7. Epub 2020 May 8.

1Department of Orthopaedic Surgery, University of Tokyo; and.

Objective: The incidence and risk factors for the progression of ossification of the posterior longitudinal ligament (OPLL) have been previously reported in surgically and nonsurgically treated symptomatic patients. However, the correlates of OPLL progression in asymptomatic subjects with OPLL are not well characterized. This study aimed to clarify the incidence and risk factors for OPLL progression in asymptomatic subjects based on whole-body CT. Read More

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http://dx.doi.org/10.3171/2020.3.SPINE2082DOI Listing

Extract Alleviates Monosodium Urate-Induced Acute Gouty Arthritis in Rats by Inhibiting Uric Acid and Inflammation.

Evid Based Complement Alternat Med 2020 21;2020:3095624. Epub 2020 Apr 21.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Gouty arthritis is an inflammatory joint disease closely related to hyperuricemia. It is characterized by deposition of monosodium urate crystals in the joints, resulting in an intense inflammatory process and pain. Control of hyperuricemia and anti-inflammation treatments are the main therapeutic approaches. Read More

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http://dx.doi.org/10.1155/2020/3095624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193269PMC

[Hyperuricemia in shift workers: a cross-sectional study in a spanish chemical factory].

Rev Esp Salud Publica 2020 Apr 28;94. Epub 2020 Apr 28.

Facultad de Medicina. Universidad de Cádiz. Cádiz. España.

Objective: There is no clear consensus over the findings of research into shift work and cardiovascular risk factors, such as those present in the metabolic syndrome (MetS). This is further confounded by the varying definitions of MetS and shift work. Our objective was to learn about the link between shift work, lifestyles and cardiovascular health in chemical factory workers. Read More

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Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.

Clin Rheumatol 2020 May 7. Epub 2020 May 7.

Department of Rheumatology and Immunology, Peking University International Hospital, Life Park Road No. 1 Life Science Park of Zhong Guancun, Chang Ping District, Beijing, 102206, China.

Objective: The aim of our study was to explore the serum levels of homocysteine (Hcy) and its association with clinical characteristics in patients with different types of inflammatory arthritis.

Methods: A total of 242 patients diagnosed with inflammatory arthritis (which included rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout), 49 with osteoarthritis (OA), and 36 with hyperuricaemia (HUA) and 81 healthy controls (HCs) were enrolled for comparisons.

Results: The serum Hcy levels of patients with RA, AS, and OA were comparable with those of the HC group (P > 0. Read More

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http://dx.doi.org/10.1007/s10067-020-05093-5DOI Listing

Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion.

BMC Med Genet 2020 May 6;21(1):91. Epub 2020 May 6.

Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Renal hypouricemia (RHUC) is a hereditary disorder where mutations in SLC22A12 gene and SLC2A9 gene cause RHUC type 1 (RHUC1) and RHUC type 2 (RHUC2), respectively. These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Urate metabolism is tightly interconnected with glucose metabolism, and SLC2A9 gene may be involved in insulin secretion from pancreatic β-cells. Read More

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http://dx.doi.org/10.1186/s12881-020-01031-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201978PMC

Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis.

Asian J Pharm Sci 2020 Mar 7;15(2):173-180. Epub 2019 Nov 7.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, United States.

Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water (6-7 mg/dl). The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion, the latter occurring in urine (kidney), bile (liver) and feces (intestinal tract). Reabsorption in kidney is also an important component of this process. Read More

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http://dx.doi.org/10.1016/j.ajps.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193448PMC

Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort.

Sci Rep 2020 May 5;10(1):7578. Epub 2020 May 5.

Agency for Preventive and Social Medicine, Bregenz, Austria.

Little is known about sex- and age-specific variations and temporal trends in serum uric acid (SUA) concentrations, the prevalence of hyperuricemia and its association with metabolic risk factors in the general population. Between January 1, 1985 and June 30, 2005 146,873 participants (42% women) were recruited. Prevalence of hyperuricemia was estimated applying a common (SUA > 360 µmol/L) and sex-specific cut-off points (women > 340 µmol/L, men > 420 µmol/L). Read More

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http://dx.doi.org/10.1038/s41598-020-64587-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200724PMC

Uricase-deficient rat is generated with CRISPR/Cas9 technique.

PeerJ 2020 27;8:e8971. Epub 2020 Apr 27.

Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China.

Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 technique by deleting exons 2 to 4 of the Uox gene. The uricase-deficient rats were named "Kunming-DY rats", and were apparently healthy with more than a 95% survival up to one year. Read More

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http://dx.doi.org/10.7717/peerj.8971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192158PMC

Urate-lowering therapy exerts protective effects against hypertension development in patients with gout.

J Hum Hypertens 2020 May 4. Epub 2020 May 4.

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Many studies have demonstrated that hyperuricemia is associated with hypertension (HTN) development, but few studies have explored whether urate-lowering therapy (ULT), which reverses hyperuricemia, decreases the risk of incident HTN. In this retrospective cohort study, we compared the risk of incident HTN of gout patients between those undergoing and not undergoing ULT. Risks of new-onset diabetes mellitus (DM) and chronic kidney disease (CKD) were also examined. Read More

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http://dx.doi.org/10.1038/s41371-020-0342-4DOI Listing

The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout.

J Int Med Res 2020 May;48(5):300060520902950

Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China.

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http://dx.doi.org/10.1177/0300060520902950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221481PMC

Evaluation of xanthine oxidase inhibitory activity of flavonoids by an online capillary electrophoresis-based immobilized enzyme microreactor.

Electrophoresis 2020 May 3. Epub 2020 May 3.

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P. R. China.

Xanthine oxidase (XOD) is a key enzyme in the human body to produce uric acid, and its inhibitor can be used for the treatment of hyperuricemia and gout. In this study, an online CE-based XOD immobilized enzyme microreactor (IMER) was developed for the enzyme kinetics assays and inhibitor screening. After 30 consecutive runs, the XOD activity remained about 95. Read More

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http://dx.doi.org/10.1002/elps.202000083DOI Listing
May 2020
3.028 Impact Factor

Polymorphisms Are Associated with the Presence of Premature Coronary Artery Disease and with Cardiovascular Risk Factors: The Genetics of Atherosclerotic Disease Mexican Study.

DNA Cell Biol 2020 Apr 29. Epub 2020 Apr 29.

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

The aim of this study was to evaluate the association of the polymorphisms with the presence of premature coronary artery disease (pCAD) and with cardiovascular risk factors. The study included 2163 individuals (1133 patients with pCAD and 1030 healthy controls). Seven polymorphisms (rs1363670, rs3212220, rs3212227, rs6887695, rs1433048, rs2853694, and rs1368439) were determined by TaqMan assays. Read More

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http://dx.doi.org/10.1089/dna.2020.5464DOI Listing

Multimodal Enzyme Delivery and Therapy Enabled by Cell Membrane-Coated Metal-Organic Framework Nanoparticles.

Nano Lett 2020 May 4;20(5):4051-4058. Epub 2020 May 4.

Department of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, United States.

Therapeutic enzymes used for genetic disorders or metabolic diseases oftentimes suffer from suboptimal pharmacokinetics and stability. Nanodelivery systems have shown considerable promise for improving the performance of enzyme therapies. Here, we develop a cell membrane-camouflaged metal-organic framework (MOF) system with enhanced biocompatibility and functionality. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c01654DOI Listing

Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.

J Food Biochem 2020 Apr 29:e13213. Epub 2020 Apr 29.

Institute of Food Science and Nutrition, University of Sargodha, Sargodha, Pakistan.

The aim of this study was to examine the preventive action of grapefruit juice (GFJ) against potassium oxonate-induced hyperuricemic mice. The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1β, caspase-1, NLRP3, and ASC. Read More

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http://dx.doi.org/10.1111/jfbc.13213DOI Listing
April 2020
0.741 Impact Factor

[Gout and Its Management in Clinical Practice].

Praxis (Bern 1994) 2020 Apr;109(6):439-445

Klinik für Rheumatologie, Kantonsspital St. Gallen.

Gout and Its Management in Clinical Practice Resolution of an acute attack is usually the prime objective in routine clinical management of gout. Crystal identification in synovial fluid by polarised light microscopy is considered the diagnostic gold standard. Imaging procedures such as high-resolution ultrasonography are also useful. Read More

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http://dx.doi.org/10.1024/1661-8157/a003461DOI Listing

In vitro and in silico xanthine oxidase inhibitory activity of selected phytochemicals widely present in various edible plants.

Comb Chem High Throughput Screen 2020 Apr 27. Epub 2020 Apr 27.

Beijing Advance Innovation center for Food Nutrition and Human Health, School of Food and Chemical Technology, China-Canada joint laboratory for food nutrition and health, Beijing Technology and Business University(BTBU),Beijing 100048. China.

Aims And Objective: The present study was designed to evaluate the xanthine oxidase (XO) inhibitory and antioxidant activities of 30 bioactive compounds present in edible food plants for the possible treatment of hyperuricemia.

Materials And Methods: The XO inhibitory, SO and DPPH radical scavenging activities of selected dietary polyphenols were determined by using colorimetric assays. The molecular docking analysis was performed to evaluate the insight into inhibitory mode of action of bioactive compounds against XO. Read More

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http://dx.doi.org/10.2174/1386207323666200428075224DOI Listing
April 2020
1.222 Impact Factor

Associations of Blood Heavy Metals with Uric Acid in the Korean General Population: Analysis of Data from the 2016-2017 Korean National Health and Nutrition Examination Survey.

Biol Trace Elem Res 2020 Apr 27. Epub 2020 Apr 27.

Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, # 290-3 Cheonha-dong, Dong-gu, Ulsan, 44033, South Korea.

We hypothesized that blood heavy metal levels such as lead, cadmium, and mercury were associated with uric acid level and hyperuricemia, and that this association remains significant after adjustment for other metals. We tested this hypothesis using the Korean National Health and Nutrition Examination Survey data. Beta coefficients and 95% confidence intervals (95% CIs) were calculated using multiple linear regression, and odds ratios (ORs) and 95% CIs were calculated using logistic regression in the cross-sectional study design. Read More

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http://dx.doi.org/10.1007/s12011-020-02152-5DOI Listing

Plasma xanthine oxidoreductase (XOR) activity in patients who require cardiovascular intensive care.

Heart Vessels 2020 Apr 27. Epub 2020 Apr 27.

Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels were significantly higher in the intensive care patients (6. Read More

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http://dx.doi.org/10.1007/s00380-020-01608-xDOI Listing