9,722 results match your criteria Hyperuricemia


Assessing the Causal Relationships between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital Boston MA, USA.

Objective: Hyperuricemia is closely associated with insulin resistance syndrome (and its many cardiometabolic sequalae); however, whether they are causally related has long been debated. We used bidirectional Mendelian randomization (MR) to investigate the potential causal nature and direction between insulin resistance and hyperuricemia, along with gout.

Methods: We used genome-wide association data (N=288,649 for SU, N=763,813 for gout, N=153,525 for fasting insulin) to select genetic instruments for two-sample MR analyses, using multiple MR methods to address potential pleiotropic associations. Read More

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Insulin resistance surrogates predict hypertension plus hyperuricemia.

J Diabetes Investig 2021 May 13. Epub 2021 May 13.

Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

Objective: To compare the association of hypertension plus hyperuricemia with four insulin resistance surrogates, including glucose and triglycerides (TyG index), TyG index with BMI (TyG-BMI), the ratio of triglycerides divided by HDL-C (TG/HDL-C), and a novel non-insulin-based fasting score (METS-IR).

Methods: Data from a cross-sectional epidemiological study enrolling a representative population sample aged ≥65 years were used to calculate the four indexes. The association with hypertension plus hyperuricemia and insulin resistance surrogates was examined with multinomial logistic regression and receiver operating characteristic. Read More

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An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy.

Authors:
Ron Hogg

Pediatr Nephrol 2021 May 13. Epub 2021 May 13.

, Kailua Kona, HI, USA.

In recent years, many significant advances have been made in determining which clinical manifestations and pathologic lesions can provide prognostic information for patients with IgA nephropathy (IgAN). However, some important questions remain, including the long-term consequences of hematuria, both macroscopic (MH) and microscopic (mH), in patients with IgAN. The importance of distinguishing patients who have a single episode of MH of long duration from those with recurrent episodes of short duration and the prognostic importance of the episodes of acute kidney injury (AKI) that sometimes accompany episodic MH will be discussed. Read More

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Efficacy of Ayurvedic treatment protocol in gouty arthritis - a clinical study.

J Complement Integr Med 2021 May 11. Epub 2021 May 11.

Department of Kayachikitsa, Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Kollam, India.

Objectives: Gout is an inflammatory response to the Monosodium urate crystals formed secondary to hyperuricaemia. The prevalence of gout has increased in recent years. The current conventional medical management aims at symptomatic management. Read More

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Gout-induced endothelial impairment: The role of SREBP2 transactivation of YAP.

FASEB J 2021 Jun;35(6):e21613

Department of General Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Gout is a multifaceted inflammatory disease involving vascular impairments induced by hyperuricemia. Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Mechanistically, UA- or MSU-induced SREBP2 expression and its transcriptional activity. Read More

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Prevalence of and risk factors for metabolic associated fatty liver disease in an urban population in China: a cross-sectional comparative study.

BMC Gastroenterol 2021 May 10;21(1):212. Epub 2021 May 10.

Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Metabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population.

Methods: We conducted this study in a health examination population who underwent abdominal ultrasonography in China. Read More

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Relationship between hyperuricemia and serositis in patients with lupus nephritis.

Int Urol Nephrol 2021 May 10. Epub 2021 May 10.

The Department of Nephropathy, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin Province, China.

Purpose: To investigate the clinical and pathological characteristics of lupus nephritis (LN) patients with serositis and analyse the relationship between serositis and hyperuricemia (HUA) in LN patients in northeast China.

Methods: The data of patients with LN diagnosed by renal biopsy in our hospital from April 2013 to May 2020 were retrospectively analyzed. The differences between the non-serositis and serositis groups were compared by t tests and Chi-square test. Read More

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Hepatic Accumulation of Hypoxanthine: A Link Between Hyperuricemia and Nonalcoholic Fatty Liver Disease.

Arch Med Res 2021 May 6. Epub 2021 May 6.

Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. Ciudad de México, México. Electronic address:

Background: An elevated level of plasma uric acid has been widely recognized as a risk factor for non-alcoholic fatty liver disease (NAFLD), where oxidative stress and inflammation play an important role in the pathophysiology of the disease. Although the complete molecular mechanisms involved remain unknown, while under physiological conditions uric acid presents antioxidant properties, hyperuricemia has been linked to oxidative stress, chronic low-grade inflammation, and insulin resistance, basic signs of NAFLD.

Aim Of Study: Employing in vivo experimentation, we aim to investigate whether a high-fat diet rich in cholesterol (HFD), modifies the metabolism of purines in close relationship to molecular events associated with the development of NAFLD. Read More

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Development of a fluorescence-based assay for screening of urate transporter 1 inhibitors using 6-carboxyfluorescein.

Anal Biochem 2021 May 6:114246. Epub 2021 May 6.

MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China. Electronic address:

The urate transporter 1 (URAT1) inhibitors were considered a very promising class of uricosuric agents for the treatment of hyperuricemia and gout. In vitro activity testing of these compounds has been conducted by radio-labeling uric acid for a long time. However, relatively few offer the convenience and speed of fluorescence-based assays. Read More

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Association of serum uric acid levels with COVID-19 severity.

BMC Endocr Disord 2021 May 8;21(1):97. Epub 2021 May 8.

Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital Sun Yat-Sen University, Zhuhai, Guangdong, China.

Aims: Hyperuricemia has attracted increasing attention. However, limited concern has been paid to the potential dangers of lowering serum uric acid (SUA). We observed lower levels of SUA in patients with COVID-19. Read More

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[Exploring the therapeutic mechanism of pills for hyperuricemia based on network pharmacology and molecular docking].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):579-587

School of Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the mechanism of pills for treatment of hyperuricemia based on network pharmacology and molecular docking.

Objective: The active ingredients of pills and their targets of action were predicted using TCMSP, SEA, Swiss and PharmMapper databases. GeneCards and TCD databases were searched for the disease targets related to hyperuricemia. Read More

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Prevalence of dyslipidemia and associated risk factors among adult residents of Shenmu City, China.

PLoS One 2021 7;16(5):e0250573. Epub 2021 May 7.

Shenmu Hospital Affiliated to Northwest University, Shenmu City Hospital, Shenmu, Shaanxi province, China.

Objective: Dyslipidemia is a leading risk factor for cardiovascular and cerebrovascular diseases. By collecting the blood lipid profiles among adult residents of Shenmu City in Shaanxi Province, China, we aim to assess and elucidate the prevalence and risk factors of dyslipidemia in this city.

Method: Stratified multistage sampling was used to survey 4,598 permanent adult residents in five areas of Shenmu (2 communities in the county seat, 2 in the southern area and 2 in the northern area) from September 2019 to December 2019. Read More

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Alcohol consumption and serum uric acid are synergistically associated with renal dysfunction among community-dwelling persons.

J Clin Lab Anal 2021 May 7:e23812. Epub 2021 May 7.

Department of Community Medicine, Ehime University Graduate School of Medicine, Toon, Japan.

Background: Serum uric acid (SUA) is a key risk factor contributing to renal failure, a serious public health problem. However, few studies have examined whether the interactive relationship between alcohol consumption and SUA is independently associated with the estimated glomerular filtration rate (eGFR).

Methods: Our sample comprised 742 men aged 69 ± 11 years (mean ± standard deviation) and 977 women aged 69 ± 10 years from a rural area. Read More

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Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Front Pharmacol 2021 20;12:645879. Epub 2021 Apr 20.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation and . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. Read More

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A phase 2 trial of single low doses of rasburicase for treatment of hyperuricemia in adult patients with acute leukemia.

Leuk Res 2021 Apr 24;107:106588. Epub 2021 Apr 24.

Section of Leukemia, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Rasburicase can markedly and rapidly decrease uric acid (UA) levels, thereby preventing and treating tumor lysis syndrome. However, rasburicase is expensive, especially when used as per the manufacturer's recommended dosage of 0.2 mg/kg/day for up to 5 days. Read More

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Anti-inflammatory drugs as new inhibitors to xanthine oxidase: In vitro and in silico approach.

Mol Cell Probes 2021 May 3;58:101733. Epub 2021 May 3.

Laboratory of Fundamental Sciences, University of Amar Telidji, Laghouat, Algeria.

The two important targets to treat gout disease are (1) control the hyperuricemia by the inhibition of Xanthine Oxidase (XO) and (2) treatment of acute attacks of gout by the use of anti-inflammatory drugs. It is important to distinguish between therapy to manage hyperuricemia and to reduce acute inflammation. While reducing hyperuricemia is resolved very slowly with available drugs, gout symptoms like pain and inflammation may become persistent. Read More

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Study on the independent effect of thyroid hormone based on uric acid level on NAFLD.

J Health Popul Nutr 2021 May 3;40(1):21. Epub 2021 May 3.

Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.

Objective: This study aims to explain the correlation among non-alcoholic fatty liver disease (NAFLD), hyperuricemia, and thyroid function and to find independent risk factors for each other.

Methods: Data were obtained from subjects who underwent health examination in the Health Promotion Centre of Sir Run Run Shaw Hospital of Zhejiang University from January 2017 to February 2019. The diagnosis of NAFLD was according to the clinical diagnosis of the guidelines. Read More

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Metabolic score for visceral fat and the risk of hyperuricemia in Chinese men.

Minerva Endocrinol (Torino) 2021 May 3. Epub 2021 May 3.

Department of Endocriology, Punan Hospital of Pudong New District, Shanghai, China -

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Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review.

Front Pharmacol 2021 16;12:660757. Epub 2021 Apr 16.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.

Hirudin, an acidic polypeptide secreted by the salivary glands of (also known as "Shuizhi" in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess potent anti-thrombotic effect in previous studies. Recently, increasing researches have focused on the anti-thrombotic activity of the derivatives of hirudin, mainly because these derivatives have stronger antithrombotic activity and lower bleeding risk. Read More

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MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome.

Front Pharmacol 2021 16;12:637415. Epub 2021 Apr 16.

Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, China.

MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders. Here, we measured miR-223 expression in acute and intercritical gout patients, after which we used RAW264.7 macrophages transfected with a miR-223 mimic/inhibitor to determine the function of miR-223 in monosodium urate (MSU)-induced gouty inflammation. Read More

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The inflammatory state is a risk factor for cardiovascular disease and graft fibrosis in kidney transplantation.

Kidney Int 2021 Apr 28. Epub 2021 Apr 28.

Division of Nephrology and Dialysis, Ca' Granda Foundation, Scientific Institute Ospedale Maggiore Policlinico di Milano, Milano, Italy.

Several factors, such as donor brain death, ischemia-reperfusion injury, rejection, infection, and chronic allograft dysfunction, may induce an inflammatory state in kidney transplantation. Furthermore, inflammatory cells, cytokines, growth factors, complement and coagulation cascade create an unbalanced interaction with innate and adaptive immunity, which are both heavily involved in atherogenesis. The crosstalk between inflammation and thrombosis may lead to a prothrombotic state and impaired fibrinolysis in kidney transplant recipients increasing the risk of cardiovascular disease. Read More

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Association Between Dietary Intake and Serum Uric Acid Levels in Kidney Transplant Patients.

J Ren Nutr 2021 Apr 27. Epub 2021 Apr 27.

Laboratory of Nutrition, Exercise and Health (LaNES), School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address:

Objectives: The aim of this study was to evaluate the association between dietary intake and uric acid (UA) levels in kidney transplant patients (KTPs).

Methods: A cross-sectional study was performed with 113 KTPs. Dietary intake assessment was carried out thorough two 24-hour dietary recalls using the 5-step multiple pass method. Read More

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Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout.

Expert Opin Pharmacother 2021 Apr 30:1-10. Epub 2021 Apr 30.

School of Medicine, Jikei University, Tokyo, Japan.

Introduction: Gout is an inflammatory disease triggered by deposition of urate crystals secondary to longstanding hyperuricemia, and its management implies both the treatment of flares and management of hyperuricemia. Dotinurad is a selective urate reabsorption inhibitor (SURI), potently inhibits urate transporter 1 in the apical surface of renal proximal tubular cells, and has been approved for the treatment of gout and hyperuricemia in Japan.

Areas Covered: This overview of dotinurad covers nonclinical and clinical pharmacology studies in special populations and its efficacy and safety in Japanese hyperuricemic patients with and without gout. Read More

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Autoinflammatory Features in Gouty Arthritis.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Rheumatology Unit, Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Read More

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The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients.

J Clin Med 2021 Apr 27;10(9). Epub 2021 Apr 27.

Department of Internal Medicine, Daejeon St. Mary's Hospital, Catholic University of Korea, Daejeon 34943, Korea.

Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) is a well-known primary glomerular nephropathy. Hyperuricemia is associated with a poor prognosis in IgAN patients. Read More

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Fucoidan from Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells.

Mar Drugs 2021 Apr 23;19(5). Epub 2021 Apr 23.

Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.

This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activate NF-κB, JNK and PI3K/Akt pathways, but both pathway inhibitors and FPS inhibited the UA-induced activation of these three pathways. Read More

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Hyperuricemia as a Marker of Reduced Left Ventricular Ejection Fraction in Patients with Atrial Fibrillation: Results of the POL-AF Registry Study.

J Clin Med 2021 Apr 22;10(9). Epub 2021 Apr 22.

3rd Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland.

: Hyperuricemia is an established risk factor for cardiovascular disease, including atrial fibrillation (AF). The prevalence of hyperuricemia and its clinical significance in patients with already diagnosed AF remain unexplored. : The Polish Atrial Fibrillation (POL-AF) registry includes consecutive patients with AF hospitalized in 10 Polish cardiology centers from January to December 2019. Read More

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Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases.

Int J Mol Sci 2021 Apr 18;22(8). Epub 2021 Apr 18.

Department of Kinesiology, Health and Leisure Studies, National University of Kaohsiung, Kaohsiung 81148, Taiwan.

Variants of transcription factor binding sites (TFBSs) constitute an important part of the human genome. Current evidence demonstrates close links between nucleotides within TFBSs and gene expression. There are multiple pathways through which genomic sequences located in TFBSs regulate gene expression, and recent genome-wide association studies have shown the biological significance of TFBS variation in human phenotypes. Read More

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Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway.

Antioxidants (Basel) 2021 Apr 6;10(4). Epub 2021 Apr 6.

Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders. Chrysin is a flavonoid compound found naturally in honey, propolis, and mushrooms and has anti-inflammatory and antioxidant effects. However, its mechanism of action is not clear yet. Read More

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Association Between Metabolic Associated Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study from NHANES 2017-2018.

Diabetes Metab Syndr Obes 2021 22;14:1751-1761. Epub 2021 Apr 22.

Department of Nephrology, The Chengdu Second Affiliated Hospital of Chongqing Medical University, The Third People's Hospital of Chengdu, Chengdu, People's Republic of China.

Purpose: In 2020, an international expert consensus proposed a novel concept, defined as metabolic associated fatty liver disease (MAFLD). We aimed to investigate the association between MAFLD and chronic kidney disease (CKD).

Methods: A total of 4869 subjects with demographic data, laboratory tests, and ultrasound transient elastography from National Health and Nutrition Examination Surveys of the United States (NHANES) 2017-2018 were included in the study. Read More

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