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    7124 results match your criteria Hyperuricemia

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    Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.
    Bioorg Med Chem 2017 May 6. Epub 2017 May 6.
    Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Murmanska, 1, 02660, Kyiv 94, Ukraine. Electronic address:
    Xanthine oxidase is a potential target for treatment of hyperuricemia and gout. In this study, a number of A- and B-ring carboxylated aurone derivatives were synthesized and evaluated for their ability to inhibit xanthine oxidase in vitro. According to the results obtained, two different ranges of inhibitory activity were observed. Read More

    Any link of gout disease control among hypertensive patients and onset of end-stage renal disease? Results from a population-based study.
    World J Nephrol 2017 May;6(3):132-142
    Sylvie Perreault, Faculty of Pharmacy, University of Montreal, Montreal, QC H3C 3J7, Canada.
    Aim: To determine the impact of allopurinol non-adherence as a proxy for uncontrolled disease on primary prevention of end-stage renal disease (ESRD).

    Methods: A cohort of 2752 patients with gout diagnosis was reconstructed using the Québec Régie de l'assurance maladie du Québec and MedEcho administrative databases. Eligible patients were new users of allopurinol, aged 45-85, with a diagnosis of hypertension, and treated with an antihypertensive drug between 1997 and 2007. Read More

    Are ultrasound features at the first metatarsophalangeal joint associated with clinically-assessed pain and function? A study of people with gout, asymptomatic hyperuricaemia and normouricaemia.
    J Foot Ankle Res 2017 22;10:22. Epub 2017 May 22.
    Department of Podiatry, Health & Rehabilitation Research Institute, Auckland University of Technology, Private Bag 92006, Auckland, 1142 New Zealand.
    Background: The first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. However, it is unclear whether these are related to clinically-assessed pain and function. This study aimed to determine the association between ultrasound features and clinical characteristics of the 1st MTP joint in people with gout, asymptomatic hyperuricaemia and age- and sex-matched normouricaemic individuals. Read More

    [Effects of Clostridium butyricum on serum uric acid and inflammatory mediators in rats with hyperuricemia].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 May;37(5):678-682
    Department of Internal Medicine, 413 Hospital of PLA, Zhoushan 316000, China.E-mail:
    Objective: To investigate the effects of intragastric administration of Clostridium butyricum in regulating serum uric acid, lipopolysaccharides (LPS), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in rats with hyperuricemia rats.

    Methods: Forty SD rats were randomized into 4 equal groups, namely the normal control group, hyperuricemia model group, benzbromarone (3 mg/kg daily) intervention group and live Clostridium butyricum group (1.5×10(7) CFU/day). Read More

    Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis.
    PLoS One 2017 22;12(5):e0177877. Epub 2017 May 22.
    School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P. R. China.
    Urate oxidase is a key enzyme in purine metabolism and catalyzes the oxidation of uric acid to allantoin. It is used to treat hyperuricemia and gout, and also in a diagnostic kit. In this study, error-prone polymerase chain reaction and staggered extension process was used to generate a mutant urate oxidase with improved enzyme activity from Bacillus subtilis. Read More

    Cardiovascular Disease and Gout: Real-World Experience Evaluating Patient Characteristics, Treatment Patterns, and Health Care Utilization.
    J Manag Care Spec Pharm 2017 Jun;23(6):677-683
    5 YourCareChoice, Ann Arbor, Michigan.
    Background: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone.

    Objective: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity.

    Methods: Data were assessed from a survey of U. Read More

    Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a mouse model of hyperuricemia.
    Biomed Rep 2017 May 10;6(5):539-544. Epub 2017 Apr 10.
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, Japan.
    Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate metabolism disorders; however, its effects on such disorders have not been characterized in detail. Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro. Read More

    Hyperuricemia as a Protective Factor for Mild Cognitive Impairment in Non-Obese Elderly.
    Tohoku J Exp Med 2017 ;242(1):37-42
    Department of Geriatrics, Tianjin Medical University General Hospital.
    Mild cognitive impairment (MCI) is regarded as incipient dementia. Patients with MCI have increased risk of later progressing to dementia. Blood uric acid (UA) is an important non-enzymatic antioxidant in peripheral circulation, and plays an unconfirmed protective role in MCI. Read More

    Risk reclassification ability of uric acid for cardiovascular outcomes in essential hypertension.
    Int J Cardiol 2017 May 13. Epub 2017 May 13.
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Italy. Electronic address:
    Background: Hyperuricemia is associated with incident cardiovascular events in different settings of patients. We tested whether the inclusion of uric acid (UA) in Cox models including standard risk factors allows to better stratify cardiovascular risk in a cohort of 1522 naïve hypertensives with preserved renal function.

    Methods: We used multiple Cox regression models to assess the independent effect of UA on cardiovascular outcomes, and Harrell'C index, Net Reclassification Index (NRI), and Integrated Discrimination Improvement (IDI) as indicators of the additional prognostic value of UA beyond and above that provided by standard risk factors and estimated glomerular filtration rate (e-GFR). Read More

    Serum Uric Acid level in the severity of Congestive Heart Failure (CHF).
    Pak J Med Sci 2017 Mar-Apr;33(2):330-334
    Sanan Arshad, Final Year Students (MBBS), Rehman Medical College, Peshawar Pakistan.
    Background And Objective: It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure.

    Methods: We analyze 285 patients with a diagnosis of Congestive heart failure admitted in Lady Reading Hospital Peshawar from March 1(st) to August 2016. Read More

    Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study.
    BMC Nephrol 2017 May 18;18(1):162. Epub 2017 May 18.
    Department of Nephrology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
    Background: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD.

    Methods: This was a single-center, retrospective, follow-up study. Read More

    Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia.
    Planta Med 2017 May 18. Epub 2017 May 18.
    Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea.
    Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. Read More

    An update on the animal models in hyperuricaemia research.
    Clin Exp Rheumatol 2017 May 8. Epub 2017 May 8.
    Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
    Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Read More

    Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation.
    Int J Hematol 2017 May 17. Epub 2017 May 17.
    Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Calcineurin inhibitors (CIs) such as cyclosporine A (CSA) and tacrolimus often cause renal dysfunction, resulting in increased serum creatinine, hyperkalemia, and hyperuricemia. However, the effects of CIs on sodium excretion have not been fully elucidated. We retrospectively evaluated the effects of CI administration on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). Read More

    Renal manifestations of primary mitochondrial disorders.
    Biomed Rep 2017 05 12;6(5):487-494. Epub 2017 Apr 12.
    Paulista de Medicina School, Federal University of São Paulo, Primeiro Andar CEP, São Paulo 04039-032, SP, Brazil.
    The aim of the present review was to summarize and discuss previous findings concerning renal manifestations of primary mitochondrial disorders (MIDs). A literature review was performed using frequently used databases. The study identified that primary MIDs frequently present as mitochondrial multiorgan disorder syndrome (MIMODS) at onset or in the later course of the MID. Read More

    Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study.
    PLoS One 2017 16;12(5):e0177249. Epub 2017 May 16.
    Health Management Department, the First Affiliated Hospital, College of Medicine, Southwest Medical University, Luzhou, China.
    Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease associated with high levels of serum uric acid (SUA). However, whether this relationship applies in obese subjects has been unclear, and no cohort study has previously been conducted in non-obese subjects. We therefore performed a retrospective cohort study among employees of seven companies in China to investigate whether hyperuricemia was independently associated with NAFLD in obese and non-obese subjects, respectively. Read More

    A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease.
    Pharm Res 2017 Jul 15;34(7):1477-1490. Epub 2017 May 15.
    Department of Medicine and Surgery,, University of Parma, Parco Area delle Scienze 23/A, 43124, Parma, Italy.
    Purpose: Because of the evolutionary loss of the uricolytic pathway, humans accumulate poorly soluble urate as the final product of purine catabolism. Restoration of uricolysis through enzyme therapy is a promising treatment for severe hyperuricemia caused by deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT). To this end, we studied the effect of PEG conjugation on the activity and stability of the enzymatic complement required for conversion of urate into the more soluble (S)-allantoin. Read More

    Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats.
    Mol Nutr Food Res 2017 May 12. Epub 2017 May 12.
    Department of Kinesiology, Health and Leisure Studies, National University of Kaohsiung, Kaohsiung, Taiwan.
    Scope: This study established a hyperuricemic rat model to elucidate the effect of resveratrol on the transport of UA in the kidney.

    Methods And Results: Hyperuricemia was induced in rats through daily oral gavage of a potassium oxonate and UA mixture over 3 weeks. Our results revealed that resveratrol significantly reduced the serum UA levels but not creatinine, c-creative protein, alanine aminotransferase, or aspartate aminotransferase levels in these rats. Read More

    Metabolic characteristics and renal dysfunction in 65 patients with tophi prior to gout.
    Clin Rheumatol 2017 May 10. Epub 2017 May 10.
    School of Public Health, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South Dist, Taichung City, Taiwan.
    Tophi typically occur many years after uncontrolled gout. Therefore, their development before gout remains unusual. Such patients might exhibit some characteristic differences compared with typical tophaceous gout patients. Read More

    Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo.
    Int J Mol Med 2017 Jun 3;39(6):1613-1620. Epub 2017 May 3.
    Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.
    Camellia japonica L. is a plant of which the seeds are used as a folk medicine, and it is native to South Korea, Japan and China. In previous study, triterpenes, flavonoids, tannins and fatty acids which have antiviral, antioxidant and anti inflammatory activity were reported from C. Read More

    The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study.
    BMJ 2017 May 9;357:j1794. Epub 2017 May 9.
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Objective To prospectively examine the relation between the Dietary Approaches to Stop Hypertension (DASH) and Western diets and risk of gout (ie, the clinical endpoint of hyperuricemia) in men.Design Prospective cohort study.Setting The Health Professionals Follow-up Study. Read More

    Value and Progress of Ultrasound in Diagnosis and Treatment of Hyperuricemia.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Apr;39(2):280-284
    Department of Ultrasound,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
    Uric acid is the final end-product of purine metabolism and 70% of it is excreted through the kidneys. Chronic hyperuricemia can easily cause gout and meanwhile may affect the kidneys and cardiovascular system. In recent years,the incidences of hyperuricemia and gout have gradually increased. Read More

    Tumor Lysis Syndrome: A Unique Solute Disturbance.
    Nurs Clin North Am 2017 Jun 7;52(2):309-320. Epub 2017 Apr 7.
    Department of Acute and Continuing Care, University of Texas Health Science Center at Houston, 6901 Bertner Avenue SON 654, Houston, TX 77030, USA.
    Tumor lysis syndrome (TLS) is a life-threatening disorder that is an oncologic emergency. Risk factors for TLS are well-known, but the current literature shows case descriptions of unexpected acute TLS. Solid tumors and untreated hematologic tumors can lyse under various circumstances in children and adults. Read More

    Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.
    Eur J Med Chem 2017 Apr 19;135:491-516. Epub 2017 Apr 19.
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000, Slovenia. Electronic address:
    Xanthine oxidase (XO), a versatile metalloflavoprotein enzyme, catalyzes the oxidative hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while simultaneously producing reactive oxygen species. Both lead to the gout-causing hyperuricemia and oxidative damage of the tissues where overactivity of XO is present. Over the past years, significant progress and efforts towards the discovery and development of new XO inhibitors have been made and we believe that not only experts in the field, but also general readership would benefit from a review that addresses this topic. Read More

    Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells.
    Nephrology (Carlton) 2017 May 5. Epub 2017 May 5.
    Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
    Background: Hyperuricemia is common among kidney transplant recipients and has been associated with worse graft outcome. Since episodes of acute cellular rejection and chronic humoral rejection contribute to decreased graft survival, in this study the effect of uric acid on cellular and humoral alloimmunity was evaluated.

    Methods: Cellular alloimmunity was assessed by cell proliferation in two-way mixed lymphocyte reaction (MLR) with human peripheral blood mononuclear cells (PBMC). Read More

    Cytokeratin-18 and uric acid predicts disease severity in Taiwanese nonalcoholic steatohepatitis patients.
    PLoS One 2017 4;12(5):e0174394. Epub 2017 May 4.
    Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
    Background & Aims: Identification of disease severity remains a challenge in the management of non-alcoholic steatohepatitis (NASH). Cytokeratin-18 (CK18), is a recently developed non-invasive biomarker for NASH. We aimed to assess the performance of CK18 in disease severity prediction among Taiwanese NASH patients. Read More

    Early onset hyperuricemia is a prognostic marker for kidney graft failure: Propensity score matching analysis in a Korean multicenter cohort.
    PLoS One 2017 3;12(5):e0176786. Epub 2017 May 3.
    Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea.
    It remains inconclusive whether hyperuricemia is a true risk factor for kidney graft failure. In the current study, we investigated the association of hyperuricemia and graft outcome. We performed a multi-center cohort study that included 2620 kidney transplant recipients. Read More

    Adiponectin, lipids and atherosclerosis.
    Curr Opin Lipidol 2017 Apr 29. Epub 2017 Apr 29.
    aSecond Department of Propaedeutic Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece bDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA cDepartment of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
    Purpose Of Review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Read More

    Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study.
    Am J Nephrol 2017 3;45(5):452-459. Epub 2017 May 3.
    Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
    Background: Endothelial dysfunction is an important risk factor for cardiovascular diseases to occur in end-stage renal disease patients. Febuxostat, being a novel xanthine oxidase inhibitor, is apparently having a beneficial role in improving the endothelial dysfunction; however, data among hemodialysis patients are still limited.

    Methods: A prospective, placebo-controlled, block-randomized, double-blinded study was carried out to evaluate the effect of oral febuxostat on the endothelial dysfunction in hemodialysis patients. Read More

    Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats.
    Biomed Pharmacother 2017 Apr 29;91:358-365. Epub 2017 Apr 29.
    Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China. Electronic address:
    Hyperuricemia is associated with the development of chronic kidney disease. Epithelial-to-mesenchymal transition (EMT) induced by hyperuricemia is blamed for initiation of renal fibrosis, which is one of the main characters of hyperuricemic nephropathy. Qi-Zhu-Xie-Zhuo-Fang (QZXZF) has been employed clinically for many years to treat patients with hyperuricemic nephropathy, but the mechanism underlying the therapeutic potential remains unclear. Read More

    Serum Uric Acid, Kidney Function and Acute Ischemic Stroke Outcomes in Elderly Patients: A Single-Cohort, Perspective Study.
    Neurol Int 2017 Feb 27;9(1):6920. Epub 2017 Mar 27.
    Department of Internal Medicine, Santa Casa Hospital, Loreto (AN).
    Chronic kidney disease and hyperuricemia have been associated to an increased risk and a worse prognosis in acute ischemic stroke. Several mechanisms, including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and an increased risk of atrial fibrillation could be implicated. The role of serum uric acid in this setting is still object of debate. Read More

    ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches.
    Pharmgenomics Pers Med 2017 20;10:129-142. Epub 2017 Apr 20.
    Department of Biochemistry, University of Otago, Dunedin, New Zealand.
    As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid transporter. This review discusses the relevance of ABCG2 polymorphisms in gout, possible etiological mechanisms, and treatment approaches. The 141K ABCG2 urate-increasing variant causes instability in the nucleotide-binding domain, leading to decreased surface expression and function. Read More

    [Effect of febuxostat on epithelial-to-mesenchymal transition of kidney tubules, serum interleukin-6 and transforming growth factor β(1) in hyperuricemic rats].
    Zhonghua Nei Ke Za Zhi 2017 May;56(5):363-367
    Department of Endocrinology, the 305th Hospital of PLA, Beijing 100017, China.
    Objective: To observe the effect of febuxostat on epithelial-to-mesenchymal transition (EMT) of kidney tubules and the levels of serum IL-6 nad transforming growth factor (TGF)β(1) in hyperuricemic rats. Methods: Forty male SD rats were divided into 4 groups: normal control group (NC group), oteracil potassium group (OP group), oteracil potassium with febuxostat group (OF group) and oteracil potassium with benzbromarone group (OB group). Each group had 10 rats and balanced in body weights. Read More

    TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.
    Oncotarget 2017 Apr;8(16):26918-26926
    Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
    The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Read More

    Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study.
    Int J Endocrinol 2017 26;2017:5262560. Epub 2017 Mar 26.
    Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
    The mechanisms facilitating hypertension in diabetes still remain to be elucidated. Nonalcoholic fatty liver disease (NAFLD), which is a higher risk factor for insulin resistance, shares many predisposing factors with diabetes. However, little work has been performed on the pathogenesis of hypertension in type 2 diabetes (T2DM) with NAFLD. Read More

    Treatment approaches and adherence to urate-lowering therapy for patients with gout.
    Patient Prefer Adherence 2017 19;11:795-800. Epub 2017 Apr 19.
    Division of Rheumatology/Department of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
    Gout is the most common inflammatory arthritis characterized by painful disabling acute attacks. It is caused by hyperuricemia and deposition of urate crystals in and around the joints. Long-standing untreated hyperuricemia can lead to chronic arthritis with joint damage, tophi formation and urate nephropathy. Read More

    Previous Dosage of Allopurinol Is a Strong Determinant of Febuxostat Efficacy.
    Biol Pharm Bull 2017 ;40(5):681-686
    Department of Pharmacy, Shiga University of Medical Science Hospital.
    Febuxostat has currently played pivotal role in the treatment of hyperuricemia, but there is little comprehensive information for the determinants of individual difference in efficacy of febuxostat. Therefore, the present study, a retrospective investigation, was carried out to analyze the effects of patient characteristics on the efficacy of febuxostat. A total of 225 patients who were continuously prescribed the same dose of febuxostat for 8-12 weeks from the initial therapy were enrolled in the present study. Read More

    Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient.
    Intern Med 2017 1;56(9):1071-1077. Epub 2017 May 1.
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.
    A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. Read More

    Fructose malabsorption in people with and without gout: A case-control study.
    Semin Arthritis Rheum 2017 Mar 22. Epub 2017 Mar 22.
    Department of Medicine, University of Otago, Christchurch, New Zealand; Department of Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand. Electronic address:
    Background: Higher fructose intake has been associated with hyperuricaemia and gout. Some individuals malabsorb fructose in the small intestine. The aims of this study were to determine the rate of fructose malabsorption and the effects of gout and fructose malabsorption on serum urate in people with and without gout. Read More

    Nephrolithiasis in Israel: Epidemiological Characteristics of Return Patients in a Tertiary Care Center.
    Isr Med Assoc J 2016 Dec;18(12):725-728
    Department of Urology, Sheba Medical Center, Tel Hashomer, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: The prevalence and etiology of nephrolithiasis vary, depending on geography, gender and ethnicity.

    Objectives: To analyze the demographic data of return nephrolithiasis patients in a tertiary care center.

    Methods: We retrospectively reviewed our prospective registry database of return patients seen at our outpatient clinic for nephrolithiasis. Read More

    Management of Gout and Hyperuricemia in CKD.
    Am J Kidney Dis 2017 Apr 26. Epub 2017 Apr 26.
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA. Electronic address:
    Hyperuricemia and gout, the clinical manifestation of monosodium urate crystal deposition, are common in patients with chronic kidney disease (CKD). Although the presence of CKD poses additional challenges in gout management, effective urate lowering is possible for most patients with CKD. Initial doses of urate-lowering therapy are lower than in the non-CKD population, whereas incremental dose escalation is guided by regular monitoring of serum urate levels to reach the target level of <6mg/dL (or <5mg/dL for patients with tophi). Read More

    Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice.
    Sci Rep 2017 Apr 28;7(1):1266. Epub 2017 Apr 28.
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, metabolic derangements such as insulin resistance, and prothrombotic state. In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Read More

    Hyperuricemia is associated with low cardiorespiratory fitness levels and excess weight in schoolchildren.
    J Pediatr (Rio J) 2017 Apr 24. Epub 2017 Apr 24.
    Universidade de Santa Cruz do Sul (UNISC), Programa de Pós-graduação em Promoção da Saúde, Departamento de Educação Física e Saúde, Santa Cruz do Sul, RS, Brazil. Electronic address:
    Objective: To evaluate the possible association between hyperuricemia and cardiorespiratory fitness levels/nutritional profile, grouped into a single variable, in schoolchildren.

    Method: Cross-sectional study of 2335 students from Elementary schools, aged 7-17 years of both genders, stratified by conglomerates of a municipality in Southern Brazil. Body mass index (BMI) was calculated and cardiorespiratory fitness (CRF) was assessed by the 6-minute run/walk test. Read More

    Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children.
    Int J Environ Res Public Health 2017 Apr 27;14(5). Epub 2017 Apr 27.
    Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing 100191, China.
    Nonalcoholic fatty liver disease (NAFLD) has become a serious public health problem worldwide; however, the availability of information on the prevalence of NAFLD in the general pediatric population is still limited. The primary aim of this study was to reveal the prevalence and correlates of suspected NAFLD in Chinese children at the national level. Data from the China Health and Nutrition Surveys (CHNS) was used. Read More

    An observational study on the relationship between serum uric acid and hypertension in a Northern Chinese population aged 45 to 59 years.
    Medicine (Baltimore) 2017 Apr;96(17):e6773
    Department of Burns and Orthopedics, Linyi People's Hospital, Linyi, Shandong, The People's Republic of China.
    Little is known about the relationship serum uric acid (SUA) and hypertension in Chinese population. Therefore, the aim of this study was to determine the association between SUA and hypertension in a northern Chinese population. The participants were a group of 1730 Chinese adults aged 45 to 59 years in Shandong Province, who were recruited from the Linyi Nutrition and Health Survey (2015-2016). Read More

    Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice.
    Oncotarget 2017 Apr 7. Epub 2017 Apr 7.
    State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, 100191, P.R. China.
    Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. Read More

    Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats.
    Oncotarget 2017 May;8(20):33807-33826
    Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
    The pathogenesis of hyperuricemia-induced chronic kidney disease is largely unknown. In this study, we investigated whether extracellular signal-regulated kinases1/2 (ERK1/2) would contribute to the development of hyperuricemic nephropathy (HN). In a rat model of HN induced by feeding mixture of adenine and potassium oxonate, increased ERK1/2 phosphorylation and severe glomerular sclerosis and renal interstitial fibrosis were evident, in parallel with diminished levels of renal function and increased urine microalbumin excretion. Read More

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