8,104 results match your criteria Hyperuricemia


[Formation in the phylogenesis of three pulls of cells with expressed different absorption and metabolism of fatty acids. Insulin and medium chains fatty acids.]

Klin Lab Diagn 2018 ;63(12):732-740

Moscow State University M.V. Lomonosov, 119991, Moscow.

Somatic cells at the early stages of phylogenesis realized the metabolism of long-chain fatty acids (FA), primarily palmitic saturated FA. It dominated the construction of a bilayer cell membrane and as a substrate for oxidation in mitochondria during energy production. Later, polyene FAs became involved in the construction of the cell membrane, the membranes of intracellular organelles, and became the substrate for the synthesis of biologically active eicosanoids. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-732-740DOI Listing
January 2018

Purification, Characterization, and Bioactivities of Polyphenols from Platycladus orientalis (L.) Franco.

J Food Sci 2019 Feb 19. Epub 2019 Feb 19.

the School of Food Science and Engineering, South China Univ. of Technology, Guangzhou, China.

The polyphenols (PF) from Platycladus Orientalis (L.) Franco leaves were purified by using 10 different macroporous adsorption resins. HPD-722 resin showed the best adsorption and desorption capacities. Read More

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http://doi.wiley.com/10.1111/1750-3841.14483
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http://dx.doi.org/10.1111/1750-3841.14483DOI Listing
February 2019
1 Read

Long-term prognostic impact of hyperuricemia in community.

Scand J Clin Lab Invest 2019 Feb 19:1-6. Epub 2019 Feb 19.

a Department of Internal Medicine , Päijät-Häme Central Hospital , Lahti , Finland.

The debate whether an elevated level of serum uric acid (SUA) is an independent marker of cardiovascular risk is still going on. We examined morbidity and mortality related to SUA and hyperuricemia in a well-characterized population with very long follow-up. Study included 4696 participants (aged 30-59 years at baseline) of the coronary heart disease (CHD) Study of the Finnish Mobile Clinic Health Examination Survey. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576098DOI Listing
February 2019

Molecular alterations induced by fructose and its impact on metabolic diseases

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):491-504. Epub 2019 Jan 28.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Bioquímica. Ciudad de México, México

Scientific evidence has identified that the excessive consumption of products made from high-fructose corn syrup is a trigger for obesity, whose prevalence increased in recent years. Due to the metabolic characteristics of fructose, a rapid gastric emptying is produced, altering signals of hunger-satiety and decreasing the appetite. In addition to the hepatic level during catabolism, triose phosphate is generated and adenosine triphosphate (ATP) is reduced, producing uric acid. Read More

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January 2019

Glomerular filtration rate in patients with moderate to severe psoriasis.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Psoriasis could be associated to comorbidities that can affect kidney function, including diabetes mellitus, arterial hypertension and hyperuricaemia. Chronic kidney disease (CKD) affects up to 10.4% of patients with psoriasis , and it is a risk factor for renal failure, cardiovascular diseases and overall mortality. Read More

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http://doi.wiley.com/10.1111/jdv.15506
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http://dx.doi.org/10.1111/jdv.15506DOI Listing
February 2019
1 Read

Synovial fluid leukocyte count in asymptomatic hyperuricaemia with crystal deposition: a proof-of-concept study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Sección de Reumatología, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez023DOI Listing
February 2019
1 Read

Identification and Extraction Optimization of Active Constituents in Seib ex TANAKA Peel and Its Biological Evaluation.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Korea.

Seib ex TANAKA possesses various biological effects. It has been used in oriental remedies for blood circulation and the common cold. Recently, biological effects of peel have been reported. Read More

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http://dx.doi.org/10.3390/molecules24040680DOI Listing
February 2019
3 Reads

Pharmacological urate-lowering approaches in chronic kidney disease.

Eur J Med Chem 2019 Jan 23;166:186-196. Epub 2019 Jan 23.

Kidney Research Laboratory, Division of Nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Chronic kidney disease (CKD) has become a global public health issue and uric acid (UA) remains a major risk factor of CKD. As the main organ for the elimination of UA, kidney owned a group of urate transporters in tubular epithelium. Kidney disease hampered the UA excretion, and the accumulation of serum UA in return harmed the renal function. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.043DOI Listing
January 2019
1 Read

[The person in philogenesis is not (omnivores), but the herbivores with the carnivores past and the fuzzy future. Biological function of trophology (nutrition) in ontogenesis.]

Klin Lab Diagn 2018 ;63(10):596-604

«Northern (Arctic) Federal University. M.V. Lomonosov», Arkhangelsk.

According to the phylogenetic theory of general pathology, seven biological functions have been formed over billions of years. 1. biological function of trophology, nutrition; 2. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-596-604DOI Listing
January 2018
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The Daniel K. Inouye College of Pharmacy Scripts: Perspectives on the Epidemiology of Gout and Hyperuricemia.

Authors:
Youssef M Roman

Hawaii J Med Public Health 2019 Feb;78(2):71-76

Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI.

Gout is the most common inflammatory arthritic condition affecting more men than women. Hyperuricemia and the deposition of urate crystals into the joints are the hallmarks of gout. The prevalence of gout and hyperuricemia is rising in the United States and world-wide possibly due to the aging population, comorbidities, and other lifestyle factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369891PMC
February 2019
1 Read

Association of hyperuricemia with metabolic syndrome among university workers: sex and occupational differences.

Afr Health Sci 2018 Dec;18(4):842-851

State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.

Background: The relationship between metabolic syndrome (MetS) and hyperuricemia is not fully understood.

Objective: To examine the association of hyperuricemia with MetS and the component of MetS that is mostly influenced by hyperuricemia among university workers.

Methods: Anthropometric measurements, blood pressure, glucose, lipid profiles, renal function tests were measured in 1198 male and 1075 female (22-60 years old) workers on annual medical examination. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354883PMC
December 2018
1 Read

Association between smoking and serum uric acid in Korean population: Data from the seventh Korea national health and nutrition examination survey 2016.

Medicine (Baltimore) 2019 Feb;98(7):e14507

The aim of this study was to identify any association between serum uric acid and smoking status using data from the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-1) 2016 of the Korean population.This study used a cross-sectional design and analyzed 5609 subjects aged ≥ 19 years among 8150 participants enrolled in the KNHANES VII-1 2016. Smoking status was classified into current smokers, never smokers, and ex-smokers. Read More

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http://dx.doi.org/10.1097/MD.0000000000014507DOI Listing
February 2019
1 Read

Secretion of IL-1β From Monocytes in Gout Is Redox Independent.

Front Immunol 2019 29;10:70. Epub 2019 Jan 29.

Clinical and Experimental Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom.

The pro-inflammatory cytokine interleukin-1β (IL-1β) plays important roles in immunity but is also implicated in autoimmune disease. The most well-established mechanism of IL-1β secretion is via activation of the NOD-like receptor family pyrin domain containing-3 (NLRP3) inflammasome which requires an initial priming signal followed by an activating signal. However, the precise mechanism by which the inflammasome is activated remains unclear. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361747PMC
January 2019
1 Read

Associations Between Serum Uric Acid Levels and Cardiometabolic Risk, Renal İnjury in Obese and Overweight Children

J Clin Res Pediatr Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Manisa Celal Bayar University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey

Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children.

Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL). Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0241DOI Listing
February 2019
2 Reads

Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.

Clin Pharmacol Drug Dev 2019 Feb 13. Epub 2019 Feb 13.

AstraZeneca, Gaithersburg, MD, USA.

Lesinurad is a selective uric acid reabsorption inhibitor approved for use in combination with xanthine oxidase inhibitors for the treatment of hyperuricemia associated with gout. In vitro, lesinurad was shown to be a weak inhibitor of cytochrome P450 (CYP)2C9 and a weak inducer of CYP3A4. Warfarin is a widely prescribed oral coumarin-based anticoagulant commonly prescribed in gout patients. Read More

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http://dx.doi.org/10.1002/cpdd.662DOI Listing
February 2019
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Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.

Clin Pharmacol Drug Dev 2019 Feb 12. Epub 2019 Feb 12.

AstraZeneca, Gaithersburg, MD, USA.

Two clinical studies were performed in healthy volunteers to investigate food and antacid effects on lesinurad, a novel selective uric acid reabsorption inhibitor approved for treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors. Study 1 evaluated a high-fat, high-calorie meal or high doses of antacids (3000 mg calcium carbonate or 1600 mg magnesium hydroxide/1600 mg aluminum hydroxide) on the pharmacokinetics (PK) and pharmacodynamics (PD) of 400 mg oral lesinurad. Study 2 evaluated low doses of antacids (1250 mg calcium carbonate or 800 mg magnesium hydroxide/800 mg aluminum hydroxide) on the PK and PD of 400 mg lesinurad. Read More

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http://dx.doi.org/10.1002/cpdd.663DOI Listing
February 2019
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Association of uric acid with stenosis of intracranial and extracranial arteries in elderly patients with cerebral infarction.

Neurol Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Zhongshan North Road 34, Quanzhou, 362000, Fujan, China.

Background: To determine whether uric acid (UA) and intracranial and extracranial atherosclerosis stenosis of elderly patients suffering from ischaemic stroke are inter-related.

Methods: Elderly patients with ischaemic stroke underwent computed tomography angiography (CTA) were enrolled between October 2015 and December 2017. We collected clinical assessment, image data, and laboratory tests, and divided patients into four groups: (1) intracranial stenosis atherosclerosis (ICAS) group, (2) combined intracranial and extracranial atherosclerosis stenosis (COAS) group, (3) extracranial carotid stenosis atherosclerosis (ECAS) group, and (4) non-cerebral stenosis atherosclerosis (NCAS) group. Read More

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http://dx.doi.org/10.1007/s10072-019-03737-2DOI Listing
January 2019
1 Read

The predictive value of the renal resistive index for contrast-induced nephropathy in patients with acute coronary syndrome.

BMC Cardiovasc Disord 2019 Feb 11;19(1):36. Epub 2019 Feb 11.

Southern Medical University , Guangzhou, 510515, China.

Background: Percutaneous coronary intervention (PCI) has been associated with contrast-induced nephropathy (CIN) at a rate that varies depending on the patient's risk factors. This study was conducted to evaluate the predictive value of the renal resistive index (RRI) for CIN in patients with acute coronary syndrome (ACS) undergoing PCI.

Methods: This prospective study enrolled 146 consecutive patients with ACS. Read More

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http://dx.doi.org/10.1186/s12872-019-1017-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371464PMC
February 2019
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Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome.

Drug Deliv 2019 Dec;26(1):70-77

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China.

Gout is a kind of joint disease characterized by the accumulation of monosodium urate (MSU) crystals in the joint and its surrounding tissue, causing persistent hyperuricemia. Colchicine is the first choice of treatment for acute gout attacks. Due to strong toxicity of colchicines oral tablets, there are high fluctuations of blood drug concentration and serious irritation of gastrointestinal tract, and hence a transdermal preparation can help to slow down the blood drug concentration, reduce the frequency of drug taking, and improve the patients' compliance of the drug. Read More

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http://dx.doi.org/10.1080/10717544.2018.1559258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374970PMC
December 2019
1 Read

Inhibitors of xanthine oxidase: scaffold diversity and structure-based drug design.

ChemMedChem 2019 Feb 10. Epub 2019 Feb 10.

MALAYSIA.

Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines in the body and their conversion to uric acid. XO is thus the target enzyme for the treatment of hyperuricemia and gout. For more than 50 years the only drug inhibitor of XO available on the market was the purine analogue allopurinol. Read More

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http://dx.doi.org/10.1002/cmdc.201900034DOI Listing
February 2019
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Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.

J Inherit Metab Dis 2019 Jan;42(1):178-185

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, Via A. Moro 2, 53100 Siena, Italy.

Lesch-Nyhan disease (LND) is a rare X-linked genetic disorder, with complete hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, uric acid (UA), hypoxanthine and xanthine accumulation, and a devastating neurologic syndrome. UA excess, causing renal failure, is commonly decreased by xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, yielding a xanthine and hypoxanthine increase. Xanthine accumulation may result in renal stones, while hypoxanthine excess seems involved in the neurological disorder. Read More

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http://dx.doi.org/10.1002/jimd.12039DOI Listing
January 2019
1 Read

Association between allopurinol and cardiovascular outcomes and all-cause mortality in diabetes: A retrospective, population-based cohort study.

Diabetes Obes Metab 2019 Feb 8. Epub 2019 Feb 8.

Dept of Medicine, University of Toronto, Toronto, ON, Canada.

Aims: Hyperuricemia is common in diabetes and is associated with cardiovascular morbidity and mortality. However, the impact of allopurinol has not been well-studied. We assessed the association between allopurinol and mortality and cardiovascular outcomes in an allopurinol-treated diabetes cohort. Read More

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http://dx.doi.org/10.1111/dom.13656DOI Listing
February 2019
1 Read

The clinical characteristics of Chinese patients with unilateral renal agenesis.

Clin Exp Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: We aimed to investigate the clinical characteristics of Chinese patients with unilateral renal agenesis.

Methods: We enrolled patients with unilateral renal agenesis diagnosed radiologically at the Department of Nephrology from January 2008 to January 2016. Patients with a solitary kidney due to nephrectomy or renal atrophy due to secondary factors were excluded. Read More

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http://dx.doi.org/10.1007/s10157-019-01704-xDOI Listing
February 2019
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New xanthine oxidase inhibitors from the fruiting bodies of Tyromyces fissilis.

Biosci Biotechnol Biochem 2019 Feb 7:1-11. Epub 2019 Feb 7.

a Graduate School of Science and Technology, Department of Agriculture , Shinshu University , Nagano , Japan.

Excessive uric acid production, which causes gout and hyperuricemia, can be blocked by inhibiting xanthine oxidase (XO). However, some agents to block on XO often cause side effects, thereby necessitating the identification of new inhibitors. During the screening of XO inhibitors from various mushroom extracts, we found that a methanolic extract of the fruiting bodies of Tyromyces fissilis, an inedible and non-toxic fungus, showed inhibitory activity. Read More

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http://dx.doi.org/10.1080/09168451.2019.1576501DOI Listing
February 2019
2 Reads

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy.

Diabetes 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Medical College of Georgia, Augusta, University, Augusta, GA 30912

We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human retinas and vitreous from donors with DR, we have found a significant increase in MSU levels which correlated with the presence of inflammatory markers and enhanced expression of xanthine oxidase. Same elevation in MSU levels was also detected in serum and vitreous of streptozotocin-induced diabetic rats (STZ-rats) analyzed at 8 weeks of hyperglycemia. Read More

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http://dx.doi.org/10.2337/db18-0912DOI Listing
February 2019
1 Read
8.095 Impact Factor

Hyperuricemia, urine uric excretion, and associated complications in thalassemia patients.

Ann Hematol 2019 Feb 5. Epub 2019 Feb 5.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Thalassemia patients have a high cell turnover rate due to chronic hemolysis and ineffective erythropoiesis; therefore, hyperuricemia is anticipated. This study aimed to identify the prevalence of hyperuricemia, gout and nephrolithiasis, conditions associated with serum uric acid (SUA), and urine uric acid excretion (UUA) in thalassemia patients. This was a cross-sectional study in patients aged 15 years or older at Chiang Mai University Hospital. Read More

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http://dx.doi.org/10.1007/s00277-019-03630-0DOI Listing
February 2019
2 Reads
2.634 Impact Factor

Somatic and sociodemographic predictors of depression outcome among depressed patients with coronary artery disease - a secondary analysis of the SPIRR-CAD study.

BMC Psychiatry 2019 Feb 4;19(1):57. Epub 2019 Feb 4.

Department of Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany.

Background: Depressive symptoms are common in patients with coronary artery disease (CAD) and are associated with an unfavourable outcome. Establishing prognostic patient profiles prior to the beginning of mental health care may facilitate higher efficacy of targeted interventions. The aim of the current study was to identify sociodemographic and somatic predictors of depression outcome among depressed patients with CAD. Read More

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http://dx.doi.org/10.1186/s12888-019-2026-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360727PMC
February 2019
1 Read

Exploration of Machine Learning for Hyperuricemia Prediction Models Based on Basic Health Checkup Tests.

J Clin Med 2019 Feb 2;8(2). Epub 2019 Feb 2.

Department of Biomedical Science, Seoul National University Graduate School, Seoul 03081, Korea.

Background: Machine learning (ML) is a promising methodology for classification and prediction applications in healthcare. However, this method has not been practically established for clinical data. Hyperuricemia is a biomarker of various chronic diseases. Read More

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http://dx.doi.org/10.3390/jcm8020172DOI Listing
February 2019
1 Read

Phytochemical Analysis and Potential Biological Activities of Essential Oil from Rice Leaf.

Molecules 2019 Feb 2;24(3). Epub 2019 Feb 2.

Department of Biotechnology, NTT Institute of Hi-Technology, Nguyen-Tat-Thanh University, 298A-300A Nguyen-Tat-Thanh Street, 13 Ward, District 04, Ho Chi Minh City 72820, Vietnam.

Although many investigations on phytochemicals in rice plant parts and root exudates have been conducted, information on the chemical profile of essential oil (EO) and potent biological activities has been limited. In this study, chemical compositions of rice leaf EO and in vitro biological activities were investigated. From 1. Read More

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http://dx.doi.org/10.3390/molecules24030546DOI Listing
February 2019
2 Reads

Hyperuricemia predicts adverse clinical outcomes after cardiac resynchronization therapy.

Scand Cardiovasc J 2018 Oct 3;52(5):250-255. Epub 2019 Feb 3.

a Heart and Vascular Center, Semmelweis University , Budapest , Hungary.

Objectives: Changes in the levels of serum creatinine and N-terminal of prohormone brain natriuretic peptide (NT-proBNP) are useful risk markers after cardiac resynchronization therapy (CRT). The diagnostic value of changes in serum uric acid levels has been established in chronic heart failure, but no data are available on the prognostic value of hyperuricemia in a CRT population.

Design: We measured markers of renal function [creatinine, blood urea nitrogen (BUN) and uric acid] and NT-proBNP levels of 129 heart failure patients undergoing CRT in a prospective, observational study. Read More

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http://dx.doi.org/10.1080/14017431.2018.1499954DOI Listing
October 2018
1 Read

A Rare Case of Spontaneous Tumor Lysis Syndrome in Idiopathic Primary Myelofibrosis.

Am J Case Rep 2019 Feb 3;20:146-150. Epub 2019 Feb 3.

Department of Hemato-Oncology, Chosun University Hospital, Gwangju, South Korea.

BACKGROUND Tumor lysis syndrome (TLS) is an oncologic emergency resulting from the massive destruction of tumor cells after cytotoxic chemotherapy for chemosensitive malignancies with a high tumor burden. Its clinical manifestations include severe electrolyte disturbances, metabolic acidosis, acute renal failure secondary to urate deposition in the kidney, heart, and skeletal muscle, and nervous system dysfunction. We report an extremely rare case of spontaneous TLS (STLS) in idiopathic primary myelofibrosis (PMF). Read More

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http://dx.doi.org/10.12659/AJCR.912682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369657PMC
February 2019
2 Reads

Apelin-13 reduces oxidative stress induced by uric acid via downregulation of renin-angiotensin system in adipose tissue.

Toxicol Lett 2019 May 30;305:51-57. Epub 2019 Jan 30.

Department of Endocrinology, Wuhan General Hospital of the Chinese People's Liberation Army, Wuhan, China.

Apelin-13, a novel adipocytokine, is found to be a powerful antioxidant. Our previous work reported that uric acid could induce oxidative stress via an activation of renin-angiotensin system (RAS) in 3T3-L1 adipocytes. In the present study, we tried to observe the effect of apelin-13 on uric acid-induced oxidative stress. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.01.014DOI Listing
May 2019
1 Read

Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis.

Semin Arthritis Rheum 2019 Jan 11. Epub 2019 Jan 11.

Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Objectives: Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.004DOI Listing
January 2019
1 Read

Gout. New opportunities of diagnosis and treatment.

Authors:
S P Yakupova

Ter Arkh 2018 May;90(5):88-92

Associate Professor at Hospital Therapy Department Federal State Budgetary Educational Institution of Higher Education "Kazan Medical University" of the Ministry of Healthcare of the Russian Federation, Kazan, Russia.

In recent yearsincidences of gout has increased. Despite the current diagnostic possibilities, doctors face the difficultiesin establishing the diagnosis. In 2015new criteria of diagnosis of goutwere developed by European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR). Read More

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http://dx.doi.org/10.26442/terarkh201890588-92DOI Listing
May 2018
1 Read

Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta-analysis.

Eur J Clin Invest 2019 Jan 30:e13074. Epub 2019 Jan 30.

Department of CCU, The No.6 people's hospital, Huizhou city, Huizhou, Guangdong province, P.R. China, (516200).

Background: The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) are conflicting. This meta-analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.

Methods: A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI, and WanFang databases up to June 16, 2018. Read More

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http://dx.doi.org/10.1111/eci.13074DOI Listing
January 2019
1 Read

Hyperuricemia Predicts an Early Decline in Renal Function among Older People: A Community-Based Cohort Study.

Sci Rep 2019 Jan 30;9(1):980. Epub 2019 Jan 30.

Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Whether elevated serum uric acid levels (SUA) predict renal dysfunction remains controversial in the elderly. Therefore, we investigated the association between SUA and early renal function decline defined as an estimated glomerular filtration rate (eGFR) reduction ≥30% over 2 years. From 2001 to 2010, we conducted a longitudinal cohort study comprising 44,078 participants aged ≥65 years in the Taipei City Elderly Health Examination Database. Read More

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http://dx.doi.org/10.1038/s41598-018-37529-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353916PMC
January 2019
1 Read

Reporting, presentation and wording of recommendations in clinical practice guideline for gout: a systematic analysis.

BMJ Open 2019 Jan 29;9(1):e024315. Epub 2019 Jan 29.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Objectives: We systematically analysed recommendations from gout guidelines as an example, to provide a basis for developing a reporting standard of recommendations in clinical practice guidelines (CPGs).

Design: Systematic review without meta-analysis.

Methods: We systematically searched MEDLINE and all relevant guideline websites (National Institute for Health and Care Excellence, National Guideline Clearinghouse, Scottish Intercollegiate Guidelines Network, WHO, Guidelines International Network, DynaMed, UpTodate, Best Practice) from their inception to January 2017 to identify and select gout CPGs. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02431
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-024315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352818PMC
January 2019
4 Reads

Xanthine Oxidase Inhibitory Potential, Antioxidant and Antibacterial Activities of (L.) Link Fruiting Body.

Medicines (Basel) 2019 Jan 29;6(1). Epub 2019 Jan 29.

Graduate school for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan.

is a medicinal mushroom and has been extensively used as a folk medicine in East Asia. In this study, the separation of constituents involved in xanthine oxidase (XO) inhibitory, antioxidant and antibacterial properties of was conducted. The aqueous residue of this fungus was extracted by methanol and then subsequently fractionated by hexane, chloroform, ethyl acetate and water. Read More

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http://dx.doi.org/10.3390/medicines6010020DOI Listing
January 2019
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Association between platelet distribution width and serum uric acid in Chinese population.

Biofactors 2019 Jan 30. Epub 2019 Jan 30.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. Read More

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http://dx.doi.org/10.1002/biof.1491DOI Listing
January 2019
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Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study.

Aging Clin Exp Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China.

Background: The association between uric acid (UA) and coronary artery disease (CAD) was controversial. It was still unclear how the UA level changes with age and gender.

Aims: To confirm the relationship between the change of UA with age and gender and CAD, especially in elderly people. Read More

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http://dx.doi.org/10.1007/s40520-019-01137-2DOI Listing
January 2019
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Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice.

Food Funct 2019 Feb;10(2):867-878

Department of Nutrition, School of Public Health, Sun Yat-Sen University (North Campus), Guangzhou, 510080, P. R. China.

Hyperuricemia (HUA) is a universal metabolic disorder characterized by a high level of uric acid in the serum. Anthocyanins (ACNs) are a group of natural flavonoids that have shown favourable bioactivities in the metabolic syndrome but the effect on uric acid metabolism remains underexplored. The present study investigated the hypouricemic effects of ACNs in a mice model and further studied the potential mechanisms. Read More

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http://dx.doi.org/10.1039/c8fo02124dDOI Listing
February 2019
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Hyperuricemia and gout are associated with cancer incidence and mortality: A meta-analysis based on cohort studies.

J Cell Physiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

The association between hyperuricemia or gout and cancer risk has been investigated in various published studies, but their results are conflicting. We conducted a meta-analysis to investigate whether hyperuricemia or gout was associated with the cancer incidence and mortality. Linear and nonlinear trend analyses were conducted to explore the dose-response association between them. Read More

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http://doi.wiley.com/10.1002/jcp.28138
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http://dx.doi.org/10.1002/jcp.28138DOI Listing
January 2019
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Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study.

J Diabetes Res 2018 30;2018:6905720. Epub 2018 Dec 30.

School of Public Health, Capital Medical University, Beijing, China.

Background: Hyperuricemia is known to be a risk factor for diabetes. However, information is limited regarding the association between changes in hyperuricemia and the risk of diabetes.

Methods: A total of 15,403 participants who were free of diabetes at the time of 2009 and 2011 surveys in the Beijing Health Management Cohort (BHMC) study were recruited and followed up until 2016. Read More

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http://dx.doi.org/10.1155/2018/6905720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332976PMC
December 2018
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Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis.

FEBS J 2019 Jan 28. Epub 2019 Jan 28.

Institute of Metabolic Diseases, Qingdao University, China.

Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and cardiovascular disease. However, the role of soluble serum urate (SU) on atherosclerosis development remains elusive. Read More

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http://dx.doi.org/10.1111/febs.14768DOI Listing
January 2019
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Socioeconomic and geographic variations in the prevalence, awareness, treatment and control of dyslipidemia in middle-aged and older Chinese.

Atherosclerosis 2019 Jan 19;282:57-66. Epub 2019 Jan 19.

Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China. Electronic address:

Background And Aims: Unevenly socioeconomic development and nutrition transition might bring large variations in the epidemiology of dyslipidemia. We aimed to estimate the prevalence, awareness, treatment and control of dyslipidemia in different socioeconomic statuses and geographic regions in China, and to assess the associated factors and comorbidities of dyslipidemia.

Methods: We included participants aged 45 years and above from a nationally representative investigation: the China Health and Retirement Longitudinal Study 2011. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.005DOI Listing
January 2019

Vitamin D Insufficiency and Deficiency are Associated with a Higher Level of Serum Uric Acid: A Systematic Review and Meta-analysis.

Mod Rheumatol 2019 Jan 28:1-15. Epub 2019 Jan 28.

c Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

Introduction/objectives: Several epidemiological studies have suggested that patients with vitamin D insufficiency and deficiency tend to have a higher level of serum uric acid compared with those with adequate vitamin D level although the results were inconsistent across the studies. The current systematic review and meta-analysis was conducted with the aim to summarize all the available data.

Method: A systematic review was conducted using MEDLINE and EMBASE database from inception to May 2018 to identify all studies that compared the level of serum uric acid between individuals with normal vitamin D level and patients with vitamin D insufficiency/deficiency. Read More

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http://dx.doi.org/10.1080/14397595.2019.1575000DOI Listing
January 2019

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

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http://dx.doi.org/10.2174/1871526519666190128102039DOI Listing
January 2019
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Clinical features and recurrent attack in gout patients according to serum urate levels during an acute attack.

Korean J Intern Med 2019 Jan 28. Epub 2019 Jan 28.

Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: A substantial portion of gout patients have normal serum urate levels during an acute attack but data on the clinical characteristics and risk of recurrence compared with hyperuricemic patients are limited.

Methods: In this retrospective cohort study, clinical features of normouricemic and hyperuricemic patients were compared. Multivariate analysis was performed to determine whether normouricemic patients were less likely to have a recurrent attack. Read More

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http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.205
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http://dx.doi.org/10.3904/kjim.2018.205DOI Listing
January 2019
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Common variants in the gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese.

Hereditas 2019 16;156. Epub 2019 Jan 16.

1Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiaric Disorders (Ministry of Education), Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai, 200030 People's Republic of China.

Background: Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, , exerts susceptibility for SUA fluctuation and incidence of HUA and gout in the Han Chinese population.

Results: Three sample sets of 1376 gout patients, 1290 long-term HUA subjects (no gout attack) and 1349 normouricemic controls were recruited for this study. Read More

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http://dx.doi.org/10.1186/s41065-018-0078-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335706PMC
January 2019
1 Read