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    Multiple symmetric lipomatosis and gynecomastia: A case report and relative literature review.
    J Clin Lipidol 2017 Mar 30. Epub 2017 Mar 30.
    Department of Endocrinology, The Third Hospital of Hebei Medical University, ShiJiazhuang, Hebei Province, China.
    Multiple symmetric lipomatosis is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk, and limbs. Here, we reported an extremely rare case of multiple symmetric lipomatosis in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. Read More

    Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.
    PLoS One 2017 24;12(4):e0175970. Epub 2017 Apr 24.
    Molecular Genetics of Renal Disorders, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
    Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle's loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromodulin-related (ADTKD-UMOD), characterised by hyperuricemia, gout and progressive loss of renal function. Read More

    Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway.
    Food Funct 2017 Apr 21. Epub 2017 Apr 21.
    School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China.
    This study was designed to investigate the effects of polydatin (PLD) on potassium oxonate-induced hyperuricemic rats. Hyperuricemic rats were treated with potassium oxonate (250 mg kg(-1)) intragastrically for 7 days, and polydatin (25, 50 mg kg(-1)) or allopurinol (5 mg kg(-1)) was administered to the rats 1 h after the potassium oxonate exposure. Polydatin administration decreased the levels of uric acid and creatinine in serum and urine, leading to inhibition of pro-inflammatory cytokine production in serum and kidney. Read More

    Hyperuricemia is associated with cardiovascular diseases clustering among very elderly women - a community based study in Chengdu, China.
    Sci Rep 2017 Apr 20;7(1):996. Epub 2017 Apr 20.
    Cardiovascular and Metabolic Disease Center, The Second People's Hospital of Chengdu, Chengdu, China.
    Cardiovascular epidemiological features among very elderly Chinese are still uncertain. This study aimed to describe the distribution of cardiovascular diseases and sex difference, and investigate potential risk factors for diseases clustering among very elderly Chinese. From May 2013 to May 2015, a total of 1056 very elderly were sampled in this cross-sectional study. Read More

    Evaluation of serum uric acid levels in psoriasis vulgaris.
    Turk J Med Sci 2017 Apr 18;47(2):531-534. Epub 2017 Apr 18.
    Department of Biostatistics, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
    Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Read More

    Lesinurad: A Review in Hyperuricaemia of Gout.
    Drugs Aging 2017 Apr 19. Epub 2017 Apr 19.
    Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
    Lesinurad (Zurampic(®)) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Lesinurad 200 mg once daily is indicated for use in combination with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in adults with gout who have not achieved target sUA levels with an XOI alone. Approval was based on three 12-month phase 3 trials that evaluated lesinurad in combination with allopurinol in adults with gout inadequately responsive to allopurinol (CLEAR 1 and 2) and in combination with febuxostat in adults with tophaceous gout (CRYSTAL). Read More

    Metabolic syndrome, serum uric acid and renal risk in patients with T2D.
    PLoS One 2017 19;12(4):e0176058. Epub 2017 Apr 19.
    Università degli Studi and IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genova, Italy.
    Background And Aims: Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear.

    Methods And Results: Within the AMD Annals database we identified patients with T2D and normal renal function and urine albumin excretion at baseline and regular follow-up visits during a 4-year period. Read More

    An unusual location of gouty panniculitis: A case report.
    Medicine (Baltimore) 2017 Apr;96(16):e6733
    aDepartment of Visceral Surgery bInstitute of Pathology, University Hospital CHUV, Lausanne, Switzerland.
    Rationale: Gouty panniculitis, characterised by the deposition of monosodium urate crystals in subcutaneous tissue, is a rare clinical manifestation of gout.

    Patient Concerns: The case of a 67-year-old man is reported, who presented an erythematous nodule on the upper part of the right buttock suspicious for an abscess. This was in the context of chemotherapy for non-Hodgkin's lymphoma. Read More

    In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity.
    Evid Based Complement Alternat Med 2017 22;2017:4097195. Epub 2017 Mar 22.
    Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.
    Quercus acuta Thunb. (Fagaceae) (QA) is cultivated as a dietary and ornamental plant in China, Japan, South Korea, and Taiwan. It has been widely used as the main ingredient of acorn tofu, a traditional food in China and South Korea. Read More

    Clinical and Molecular Characterization of Patients with Fructose 1,6-Bisphosphatase Deficiency.
    Int J Mol Sci 2017 Apr 18;18(4). Epub 2017 Apr 18.
    Department of Endocrinology and Metabolism, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
    Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare, autosomal recessive inherited disease caused by the mutation of the FBP1 gene, the incidence is estimated to be between 1/350,000 and 1/900,000. The symptoms of affected individuals are non-specific and are easily confused with other metabolic disorders. The present study describes the clinical features of four Chinese pediatric patients who presented with hypoglycemia, hyperlactacidemia, metabolic acidosis, and hyperuricemia. Read More

    Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review.
    Nutrients 2017 Apr 18;9(4). Epub 2017 Apr 18.
    Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.
    There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. Recent preclinical and clinical evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, and cardiovascular disease. It is probably also an independent risk factor for chronic kidney disease, Type 2 diabetes, and cognitive decline. Read More

    New synthesis of poly ortho-methoxyaniline nanostructures and its application to construct modified multi-wall carbon nanotube/graphite paste electrode for simultaneous determination of uric acid and folic acid.
    Mater Sci Eng C Mater Biol Appl 2017 Jun 27;75:791-797. Epub 2017 Feb 27.
    Analytical Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, P.O. Box 98155-674, Iran.
    Uric acid (UA) and folic acid (FA) are compounds of biomedical interest. In humans, about 70% of daily uric acid disposal occurs via the kidneys, and in 5-25% of humans, impaired renal (kidney) excretion leads to hyperuricemia. Folate is another form folic acid of which is known as, is one of the B vitamins. Read More

    Xanthine oxidase and its role as target in cardiovascular disease: cardiovascular protection by enzyme inhibition?
    Curr Pharm Des 2017 04 17. Epub 2017 Apr 17.
    Charité - Universitaetsmedizin Berlin, Campus Benjamin Franklin, Department of Nephrology and Transplantation, Hindenburgdamm 30, 12203 Berlin, Germany.
    Background: Formerly, hyperuricemia was mainly restricted to the rich population, but now-a-days it is a condition affecting wide parts of western civilization. Although only a minority of our population develops clinically relevant symptomatic hyperuricemia, there is growing evidence that elevated serum uric acid levels might be associated with elevated cardiovascular risk and cardiovascular disease progression. But it is not clear whether uric acid is just a biomarker or exerts detrimental effects itself. Read More

    Spontaneous tumor lysis syndrome in a patient with metastatic prostate cancer.
    Mol Clin Oncol 2017 Apr 8;6(4):589-592. Epub 2017 Mar 8.
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
    Tumor lysis syndrome (TLS) is a life-threatening oncological emergency, with most cases occurring in hematological malignancies following the initiation of treatment. However, on rare occasions, TLS may occur in solid tumors as well. In the present case study, the case is reported of a 56-year-old African-American man who presented with a recent diagnosis of prostate cancer, abdominal pain, elevated transaminases, renal insufficiency, hyperkalemia, and hyperuricemia, consistent with spontaneous TLS in the setting of metastatic prostate cancer. Read More

    Bioengineered robust hybrid hydrogels enrich the stability and efficacy of biological drugs.
    J Control Release 2017 Apr 12. Epub 2017 Apr 12.
    School of Chemical Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Electronic address:
    Biological drugs are exquisitely tailored components offering the advantages of high specificity and efficacy that are considered safe for treating diseases. Nevertheless, the effectiveness of biological drugs is limited by their inherent short biological half-life and poor stability in vivo. Herein, we engineered a novel delivery platform based on hybrid injectable hydrogels, in which pH- and temperature-responsive biodegradable copolymers were site-specifically coupled to the sulfhydryl group of human serum albumin, which effectively enhances the stability and circulation half-life of the biological drug, recombinant uricase enzyme (Uox). Read More

    Development of Nephrolithiasis in Asymptomatic Hyperuricemia: A Cohort Study.
    Am J Kidney Dis 2017 Apr 12. Epub 2017 Apr 12.
    Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea. Electronic address:
    Background: Although the association between gout and nephrolithiasis is well known, the relationship between asymptomatic hyperuricemia and the development of nephrolithiasis is largely unknown.

    Study Design: Cohort study.

    Setting & Participants: 239,331 Korean adults who underwent a health checkup examination during January 2002 to December 2014 and were followed up annually or biennially through December 2014. Read More

    Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.
    Oncotarget 2017 Mar 30. Epub 2017 Mar 30.
    Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
    We have performed exome-wide association studies to identify genetic variants that influence renal function-related traits or confer susceptibility to chronic kidney disease or hyperuricemia in Japanese. Exome-wide association studies for estimated glomerular filtration rate and the serum concentration of creatinine were performed with 12,565 individuals, that for the serum concentration of uric acid with 9934 individuals, and those for chronic kidney disease or hyperuricemia with 5161 individuals (3270 cases, 1891 controls) or 11,686 individuals (2045 cases, 9641 controls), respectively. The relation of genotypes of single nucleotide polymorphisms to estimated glomerular filtration rate or the serum concentrations of creatinine or uric acid was examined by linear regression analysis, and that of allele frequencies of single nucleotide polymorphisms to chronic kidney disease or hyperuricemia was examined with Fisher's exact test. Read More

    Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells.
    Arterioscler Thromb Vasc Biol 2017 Apr 13. Epub 2017 Apr 13.
    From the Department of Medical and Surgical Sciences, Viale Europa, University Magna-Græcia of Catanzaro, Italy (R.S., E.M., C.D.F., A.F., F.P., F.A., G.C.M., G.S.); and Department of Systems Medicine, University of Rome Tor Vergata, Italy (M.A.M.).
    Objective: Serum uric acid (UA) has been associated with increased risk of cardiovascular and metabolic diseases. However, the causal mechanisms linking elevated UA levels to cardio-metabolic diseases are still unsettled. One potential explanation for how UA might contribute to cardio-metabolic disease might be its ability to induce systemic inflammation. Read More

    Mendelian randomization to establish the causality of uric acid with diabetic nephropathy in type 1 diabetics.
    Kidney Int 2017 May;91(5):1005-1007
    Dialysis Clinic, Inc., Albuquerque, New Mexico, USA; University of New Mexico, Albuquerque, New Mexico, USA. Electronic address:
    Previous studies have demonstrated an association of serum uric acid with kidney disease. However, it is unknown whether this relationship is causal. Mendelian randomization takes advantage of allele randomization at birth to assess causation. Read More

    Con: Mesoamerican nephropathy: is the problem dehydration or rehydration?
    Nephrol Dial Transplant 2017 Apr;32(4):603-606
    In recent years, an increasing number of inhabitants of Central America have developed a form of chronic kidney disease, now named Mesoamerican nephropathy. This disease is characterized by minimal proteinuria, hyperuricemia, hypokalemia and reduced glomerular filtration rate. Histologically the kidneys manifest tubulointerstitial nephritis. Read More

    Pharmacotherapy for hyperuricemia in hypertensive patients.
    Cochrane Database Syst Rev 2017 Apr 13;4:CD008652. Epub 2017 Apr 13.
    Nephrology, Rio de Janeiro State University, Av. 28 de setembro, 87, Vila Isabel, Rio de Janeiro, Rio de Janeiro, Brazil, 20551030.
    Background: High blood pressure represents a major public health problem. Worldwide, approximately one-fourth of the adult population has hypertension. Epidemiological and experimental studies suggest a link between hyperuricemia and hypertension. Read More

    Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake.
    J Cell Mol Med 2017 Apr 12. Epub 2017 Apr 12.
    Key Laboratory of Transplant Engineering and Immunology, NHFPC; Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.
    Hyperuricemia is an important risk factor for cardiovascular and renal diseases. Phloretin had shown antioxidant and anti-inflammatory properties, but its role in endothelial injury is rarely reported. In this study, we aimed to investigate the protective effect of phloretin on UA-induced injury in human umbilical vein endothelial cells. Read More

    Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study.
    Hypertension 2017 Apr 10. Epub 2017 Apr 10.
    From the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., A.A.-H., P.B., T.J., Y.S., T.M., G.G., M.A.L., R.J.J.); Department of Cardiology, Toranomon Hospital, Tokyo, Japan (M.K., M.O.); Cardiovascular Center, St Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Future Basic Medicine, Nara Medical University, Kashihara, Japan (T.N.); and Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.).
    Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic hyperuricemia and cardiometabolic conditions. Subjects consisting of Japanese adults between 30 and 85 years of age were enrolled in the study at Center for Preventive Medicine, St Luke's International Hospital, Tokyo, and were available at enrollment (2004) and at 5-year follow-up (2009). Read More

    Prevalence and risk factors of hyperuricemia: results of the Kailuan cohort study.
    Mod Rheumatol 2017 Apr 11:1-6. Epub 2017 Apr 11.
    e Department of Cardiology , Kailuan General Hospital , Tangshan , Hebei Province , China.
    Objective: The objective of this study is to determine the serum uric acid (SUA) level and the prevalence of hyperuricemia (HUA) in Chinese population.

    Methods: We conducted a cross-sectional study among 100,226 employees (79.9% male) of the Kailuan Group using physical examination data in 2006-2007. Read More

    Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis.
    Rheumatology (Oxford) 2017 Mar;56(3):457-466
    Institute of Pharmacology, Program in Molecular Medicine, School of Medicine, National Yang-Ming University, Taipei.
    Objective.: Gout is characterized by recurrent attacks of arthritis with hyperuricaemia and urate crystal-induced inflammation. Although urate transporters are known as risk factors, the immunogenetics of gouty inflammation remains unclear. Read More

    Insulin Resistance and Chronic Kidney Disease in Patients with Type 1 Diabetes Mellitus.
    J Nutr Metab 2017 14;2017:6425359. Epub 2017 Mar 14.
    University of Medicine and Pharmacy of Craiova, Craiova, Romania; Clinical Municipal Hospital "Philanthropy" of Craiova, Craiova, Romania.
    Background and Aims. Diabetes mellitus (DM) is a chronic disease which can evolve towards devastating micro- and macrovascular complications. DM is the most frequent cause of chronic kidney disease (CKD). Read More

    Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
    J Ethnopharmacol 2017 May 5;203:304-311. Epub 2017 Apr 5.
    Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, 132 Tianmushan Road, Hangzhou 310007, PR China. Electronic address:
    Ethnopharmacological Relevance: The Gnaphalium affine D. Don is used in China as a folk medicine to treat gout, anti-inflammatory, antitussive and expectorant activities. The aim of this study was to evaluate the potential of the extract of G. Read More

    Relationship between uric acid and technique failure in patients on continuous ambulatory peritoneal dialysis: a long-term observational cohort study.
    BMJ Open 2017 Apr 7;7(4):e010816. Epub 2017 Apr 7.
    Institute of Biomedical Sciences, College of Life Science, National Chung Hsing University, Taichung, Taiwan.
    Objectives: Uric acid (UA) is the product of purine or nucleotide metabolism via the pathway of xanthine oxidase or xanthine dehydrogenase. Although epidemiological studies assessing the role of UA in cardiovascular disease or mortality have produced inconsistent results, the correlation between UA and technique failure in patients on continuous ambulatory peritoneal dialysis (CAPD) remains to be assessed.

    Design: A retrospective cohort study. Read More

    Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.
    Sci Rep 2017 Apr 6;7(1):665. Epub 2017 Apr 6.
    Department of Biology, Ardea Biosciences, Inc. (A member of the AstraZeneca Group), San Diego, CA, USA.
    Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad (RDEA3170), which is currently under evaluation for gout therapy. Verinurad specifically inhibits URAT1 with a potency of 25 nM. Read More

    Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single-center cross-sectional study.
    Medicine (Baltimore) 2017 Apr;96(14):e6565
    aDepartment of Internal Medicine, Yonsei University College of Medicine Gangnam Severance Hospital, Seoul bDepartment of Internal Medicine, CHA University School of Medicine CHA Bundang Medical Center, Seongnam-si cSeverance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Recently, the pathogenic role of uric acid (UA) in both systemic metabolic and atherosclerotic diseases has been investigated. We sought to determine the independent correlation between serum UA levels and coronary artery calcification, as a marker of subclinical atherosclerosis. A total of 4188 individuals without prior coronary artery disease or urate-deposition disease were included. Read More

    Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia.
    Pediatr Nephrol 2017 Apr 5. Epub 2017 Apr 5.
    Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
    Background: Patients with sickle cell anemia (SCA) have an increased prevalence of nephropathy and mortality from chronic kidney disease (CKD).

    Methods: We evaluated the association of hyperuricemia and nocturnal hypertension with lower estimated glomerular filtration rate (eGFR) using cystatin-C in patients aged 10-21 years with the HbSS or HbSB0 form of the disease during a non-acute clinic visit. eGFR and uric acid measurements were obtained in 83 and 81 participants, respectively, and 24-h ambulatory blood pressure monitoring (ABPM) was performed in 44 participants. Read More

    Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content.
    BMC Complement Altern Med 2017 Apr 4;17(1):191. Epub 2017 Apr 4.
    College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, 34134, Republic of Korea.
    Background: The medicinal plant Siegesbeckia orientalis L. has been commonly used for the treatment of acute arthritis, rheumatism, and gout in Vietnam. However, pharmacological research of this plant associated with gout has not been reported. Read More

    Cadmium exposure and its association with serum uric acid and hyperuricemia.
    Sci Rep 2017 Apr 3;7(1):550. Epub 2017 Apr 3.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
    Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. Read More

    Population specific resequencing associates the ATP Binding Cassette Subfamily C Member 4 (ABCC4) gene with gout in New Zealand Māori and Pacific men.
    Arthritis Rheumatol 2017 Mar 28. Epub 2017 Mar 28.
    Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand.
    Objective There is no evidence for genetic association of the organic anion transporters (OAT) 1-3 (SLC22A6, SLC22A7, SLC22A8) and multi-drug resistance protein 4 (MRP4; ABCC4) with serum urate or gout. The Māori and Pacific (Polynesian) population of New Zealand (NZ) has the highest prevalence of gout worldwide. Our aim was to determine if there were any Polynesian population-specific genetic variants in the SLC22A6-8 and ABCC4 genes associated with gout. Read More

    Inborn Errors of Fructose Metabolism. What Can We Learn from Them?
    Nutrients 2017 Apr 3;9(4). Epub 2017 Apr 3.
    Center for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital (CHUV), Beaumont-02/248, Lausanne CH-1011, Switzerland.
    Fructose is one of the main sweetening agents in the human diet and its ingestion is increasing globally. Dietary sugar has particular effects on those whose capacity to metabolize fructose is limited. If intolerance to carbohydrates is a frequent finding in children, inborn errors of carbohydrate metabolism are rare conditions. Read More

    The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices.
    Int J Endocrinol 2017 7;2017:5438157. Epub 2017 Mar 7.
    Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Read More

    Uricosuric targets of tranilast.
    Pharmacol Res Perspect 2017 Apr 6;5(2):e00291. Epub 2017 Feb 6.
    Renal Divisions VA Boston Healthcare System and Brigham and Women's Hospital Boston Massachusetts.
    Uric acid, generated from the metabolism of purines, has both proven and emerging roles in human disease. Serum uric acid in humans is determined by production and by the net balance of reabsorption and secretion in kidney and intestine. In the human kidney, epithelial reabsorption dominates over secretion, such that in normal subjects there is at least 90% net reabsorption of filtered urate resulting in a fractional excretion of <10%. Read More

    Association of renal function with clinical parameters and conditions in a longitudinal population-based epidemiological study.
    Biomed Rep 2017 Feb 23;6(2):242-250. Epub 2016 Dec 23.
    Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan.
    The aim of the present study was to examine the association of renal function with clinical parameters and conditions in the general population. Study subjects comprised 6,027 community-dwelling individuals who were recruited to the Inabe Health and Longevity Study: A longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. The cutoff value, which was used to divide the subjects into those with normal and those with low estimated glomerular filtration rate (eGFR), was 60 ml/min/1. Read More

    Recent advances in understanding and managing gout.
    F1000Res 2017 10;6:247. Epub 2017 Mar 10.
    The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA.
    Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Read More

    N-acetyl cysteine versus allopurinol in the prevention of contrast nephropathy in patients with chronic kidney disease: A randomized controlled trial.
    Indian J Nephrol 2017 Mar-Apr;27(2):93-98
    Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
    Contrast media administration can lead to acute deterioration in renal function particularly in patients with pre-existing chronic kidney disease. This prospective, randomized controlled open-label parallel group study was undertaken at Nizam's Institute of Medical Sciences, Hyderabad, from June to December 2015. A total of 95 patients were included, of which 35 received n-acetylcysteine (NAC) + normal saline (NS), 30 patients received allopurinol (ALL) + NS, and 30 patients received placebo. Read More

    Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident end-stage renal disease, and mortality.
    BMC Nephrol 2017 Mar 27;18(1):103. Epub 2017 Mar 27.
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the development of end stage renal disease (ESRD) is not well-described.

    Methods: Data from 304 patients undergoing OLT between 1996 and 2010 were used to assess the association of mean serum uric acid (UA) level in the 3-months post-OLT with mortality, doubling of creatinine, and ESRD incidence. Post-OLT survival to event outcomes according to UA level and eGFR was assessed using the Kaplan Meier method and multivariate Cox proportional hazards models. Read More

    Hyperuricemia at The Time Of Diagnosis is a Factor for Poor Prognosis in Patients With Stage II and III Colorectal Cancer (Uric Acid and Colorectal Cancer)
    Asian Pac J Cancer Prev 2017 02 1;18(2):485-490. Epub 2017 Feb 1.
    Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla.
    Purpose: In this pilot study we investigated whether serum levels of uric acid, the final breakdown product of purine metabolism, might influence cancer-related events in stage II and III colorectal cancer patients. Material and methods: In this cross-sectional retrospective study, a total of 150 stage II and III colorectal adenocarcinoma patients with no exclusion criteria were included. Serum uric acid levels of the patients measured at diagnosis and demographic, clinical, laboratory analyses were performed and histologically features recorded. Read More

    Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults.
    Br J Nutr 2017 Mar 27;117(5):686-697. Epub 2017 Mar 27.
    1Laboratory of Epidemiology and Population Sciences,National Institute on Aging (NIA),National Institutes of Health, Intramural Research Program (NIH/IRP),Baltimore,MD 21224,USA.
    Serum uric acid (SUA), a causative agent for gout among others, is affected by both genetic and dietary factors, perhaps differentially by sex. We evaluated cross-sectional (SUAbase) and longitudinal (SUArate) associations of SUA with a genetic risk score (GRS), diet and sex. We then tested the interactive effect of GRS, diet and sex on SUA. Read More

    Major electrocardiographic abnormality predicts support/care-need certification and/or death in community-dwelling older adults with no history of cardiovascular disease.
    Geriatr Gerontol Int 2017 Mar 27. Epub 2017 Mar 27.
    Department of Geriatric Medicine, Kanazawa Medical University, Ishikawa, Japan.
    Aim: Not only cardiovascular disease (CVD) itself, but also subclinical major electrocardiographic (ECG) abnormalities are related to frailty in older adults. We investigated whether major ECG abnormality was associated with first support/care-need certification in Long-Term Care Insurance or death in community-dwelling older adults.

    Methods: We analyzed 1078 community-dwelling older adults with no history of certification aged 65-94 years. Read More

    Risk Factors of Hyperuricemia After Renal Transplantation and Its Long-term Effects on Graft Functions.
    Transplant Proc 2017 Apr;49(3):505-508
    Department of Nephrology, Ankara University School of Medicine, Ankara, Turkey; Transplantation Center, Ankara University School of Medicine, Ankara, Turkey.
    Background: Hyperuricemia is a common complication in renal transplant recipients. Recent studies have suggested that hyperuricemia may contribute to the deterioration of graft function.

    Methods: In this study, we aimed to investigate the risk factors related to hyperuricemia and the effects of hyperuricemia on graft dysfunction, graft survival, cardiovascular events, and mortality rates. Read More

    Discovery and Assessment of Atropisomers of (±)-Lesinurad.
    ACS Med Chem Lett 2017 Mar 14;8(3):299-303. Epub 2017 Feb 14.
    Sagacity New Drug R&D Co., Ltd. , 18 Zhenze Road, Xinwu District, Wuxi, Jiangsu 214135, P. R. China.
    (+)- and (-)-Lesinurad were isolated as atropisomers from racemic lesinurad for the first time. No interconversion was observed between the two atropisomers under various conditions tested. The two atropisomers showed significant differences in hURAT1 highly expressed HEK293 cell-based inhibition assays, monkey pharmacokinetic studies, and in vitro human recombinant CYP2C9 stability studies. Read More

    Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats.
    Oxid Med Cell Longev 2017 28;2017:3759153. Epub 2017 Feb 28.
    Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
    Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria. Read More

    Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females: A cross-sectional study.
    Endocr Res 2017 Mar 23:1-6. Epub 2017 Mar 23.
    a Department of Endocrinology , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
    Objective: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females.

    Methods: A cross-sectional population survey was performed in Luzhou, China (2014). Questionnaires, physical examinations and biochemical tests were conducted. Read More

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