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    [Relationship between hyperuricemia and adverse events in patients aged 40 years or older receiving rheumatic aortic valve replacement].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Jul;37(7):943-946
    Department of Cardiology, Guangdong Cardiovascular Institute/Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention/Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.E-mail:
    Objective: To explore the prognostic value of hyperuricemia for adverse events in patients >40 years old receiving valve replacement surgery for rheumatic aortic valve disease.

    Methds: Consecutive middle-aged and elderly patients receiving aortic valve replacement surgery for rheumatic aortic valve disease between March, 2009 and July, 2013 were recruited in this study. The patients were divided into hyperuricemic group and normouricemic group based on their serum levels of uric acid, and the clinical data and adverse events within 1 year after the surgery were compared between the 2 groups. Read More

    Increased risk for diabetes mellitus in patients with carbon monoxide poisoning.
    Oncotarget 2017 Jun 29. Epub 2017 Jun 29.
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limited. We conducted a nationwide study in Taiwan to fill the data gap. Read More

    Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.
    Kidney Int 2017 Jul 17. Epub 2017 Jul 17.
    Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China; Institute of Metabolic Diseases, Qingdao University, Qingdao, China; Department of Endocrinology and Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:
    The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. The loss of uricase in humans during primate evolution causes their vulnerability to hyperuricemia. Thus, we generated a Uox-knockout mouse model on a pure C57BL/6J background using the transcription activator-like effector nuclease (TALEN) technique. Read More

    Prevalence of chronic kidney disease in Peruvian primary care setting.
    BMC Nephrol 2017 Jul 19;18(1):246. Epub 2017 Jul 19.
    University of Connecticut/Hartford Hospital Evidence-based Practice Center, Hartford, CT, 06102, USA.
    Background: Chronic Kidney Disease (CKD) is a worldwide public health problem. There are few studies in Latin America, especially in primary care settings. Our objective was to determine the prevalence, stages, and associated factors of CKD in primary care setting. Read More

    Association between serum uric acid level and hypertension in a Chinese elderly rural population.
    Clin Exp Hypertens 2017 Jul 19:1-8. Epub 2017 Jul 19.
    a Department of Epidemiology, Institute of Geriatrics , Chinese People's Liberation Army General Hospital , Beijing , China.
    Previous studies have examined the association between elevated serum uric acid (SUA) level and hypertension; however, the association in the Chinese elderly is still uncertain. A cross-sectional study was performed in a rural district of Beijing. A total of 2,397 participants (967 men and 1,430 women) completed the survey. Read More

    Childhood-Onset Adult Growth Hormone Deficiency: Clinical, Hormonal, and Radiological Assessment in a Single Center in China.
    Horm Res Paediatr 2017 Jul 18. Epub 2017 Jul 18.
    Background: Although growth hormone deficiency (GHD) is an important issue in pediatric patients, adult GHD (AGHD) is a neglected field of endocrinology in China. The aim of this study is to characterize the clinical, hormonal, and radiological features in childhood-onset AGHD (CO AGHD) in a single center in China and to compare them with counterparts from Japan.

    Methods: The medical records of 78 Chinese patients with CO AGHD were reviewed and compared with data from the HypoCCS database study from Japan (N = 69). Read More

    Hyperuricemia is associated with an increased prevalence of paroxysmal atrial fibrillation in patients with type 2 diabetes referred for clinically indicated 24-h Holter monitoring.
    J Endocrinol Invest 2017 Jul 15. Epub 2017 Jul 15.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale A. Stefani, 1, 37126, Verona, Italy.
    Purpose: Several studies have reported an association between hyperuricemia and increased risk of permanent atrial fibrillation (AF) in patients with and without type 2 diabetes mellitus (T2DM). Currently, no published data are available on the relationship between hyperuricemia and risk of paroxysmal AF.

    Methods: We retrospectively evaluated 245 T2DM outpatients without pre-existing AF, cancer, cirrhosis and end-stage renal disease, who underwent a 24-h ECG-Holter monitoring for various clinical indications. Read More

    The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1-3.
    Oncotarget 2017 Jul 6. Epub 2017 Jul 6.
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    There is a high prevalence of hyperuricemia (HUA) in the chronic kidney disease (CKD) population. However, there's a dearth of research on HUA's prevalence, subtypes, early detection, and treatment strategies of HUA in lupus nephritis (LN) patients. The aim of this study is to address these knowledge gaps. Read More

    Effectiveness of Single-dose Rasburicase in Patients With Lymphoid Malignancies at a High Risk for Tumor Lysis Syndrome.
    Clin Lymphoma Myeloma Leuk 2017 Jun 27. Epub 2017 Jun 27.
    Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Institute for Translational Research and Molecular Imaging, Catholic Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea; Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea. Electronic address:
    Background: Tumor lysis syndrome (TLS) is a life-threatening disorder that occurs mainly in patients with high-tumor burden hemato-oncologic malignancies. It results in metabolic derangements, including hyperuricemia and acute renal failure. The powerful management for TLS is a daily dose of rasburicase for up to 5 days before chemotherapy; however, the optimal dose and duration of rasburicase for TLS prophylaxis have not been standardized for patients at high risk for TLS. Read More

    Genomic Influences on Hyperuricemia and Gout.
    Rheum Dis Clin North Am 2017 Aug;43(3):389-399
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand. Electronic address:
    Genome-wide association studies (GWAS) have identified nearly 30 loci associated with urate concentrations that also influence the subsequent risk of gout. The ABCG2 Q141 K variant is highly likely to be causal and results in internalization of ABCG2, which can be rescued by drugs. Three other GWAS loci contain uric acid transporter genes, which are also highly likely to be causal. Read More

    Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population.
    Sci Rep 2017 Jul 14;7(1):5456. Epub 2017 Jul 14.
    Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
    Hyperuricemia is common in China and the relevance of hyperuricemia and cardiovascular disease (CVD) risk has been highlighted, but to date there has been rarely nation-wide study in China. Here, we aim to estimate the current prevalence of hyperuricemia and evaluate the associations between hyperuricemia and cardiovascular risk factors (CRFs) clustering in a large sample of China adults including a plurality of ethnic minorities. Generally, a nationally representative sample of 22983 adults aged ≥18 years was recruited from 2007 to 2011. Read More

    Intestinal absorption of Pallidifloside D are limited by P-glycoprotein in mice.
    Xenobiotica 2017 Jul 14:1-22. Epub 2017 Jul 14.
    a Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
    1. Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be very effective in hyperuricemic control. But it is poorly bioavailable after oral administration. Read More

    Serum Uric Acid and Arterial Function After Renal Transplantation.
    Ann Transplant 2017 Jul 14;22:431-439. Epub 2017 Jul 14.
    Medical Department I, University Clinic Marienhospital Herne, Ruhr-University of Bochum, Herne, Germany.
    BACKGROUND Hyperuricemia is associated with an increased risk of cardiovascular disease and chronic allograft nephropathy after renal transplantation. It has recently been demonstrated that treatment of asymptomatic hyperuricemia is associated with improved patient and graft survival; although, the underlying mechanisms remain elusive. The present study investigated the association of serum uric acid (SUA) and systemic arterial function after renal transplantation. Read More

    Tophaceous Gout in the Lumbar Spinal Canal Mimicking Epidural Spinal Tumor.
    Korean J Spine 2017 Jun 30;14(2):50-52. Epub 2017 Jun 30.
    Department of Neurosurgery, Korea University Ansan Hospital, Ansan, Korea.
    Gout is an inflammatory arthritis characterized by deposition of monosodium urate crystals in joints. Though gout frequently involves the big toe or other extremities, it rarely occurs in the spinal canal. A 35-year-old man presented with left L5 radiculopathy. Read More

    [Hypertension].
    Rev Med Suisse 2017 Jan;13(544-545):61-65
    Service de néphrologie et hypertension, CHUV, 1011 Lausanne.
    The year 2016 has been impacted essentially by the results of the SPRINT trial published in the end of 2015. This study proposed a systolic blood pressure target of <120 mmHg for all high cardiovascular risk patients. In this review, we shall discuss the impact of this trial and the criticisms that have appeared following its publications. Read More

    Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies.
    World J Pediatr 2017 Jul 12. Epub 2017 Jul 12.
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
    Background: To review the available evidence from prospective studies on the safety and tolerability of the ketogenic diet (KD) for the treatment of refractory childhood epilepsy.

    Methods: A comprehensive bibliographic search was performed with the aim of retrieving prospective studies that monitored adverse effects (AEs) in children after receiving the classic or medium-chain triglyceride KD therapy for refractory epilepsy.

    Results: A total of 45 studies were retrieved, including 7 randomized controlled trials. Read More

    Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report.
    BMC Nephrol 2017 Jul 12;18(1):234. Epub 2017 Jul 12.
    Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter, Devon, EX2 5DW, UK.
    Background: Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. We report a novel dominant REN mutation discovered in an individual after forty years of renal disease.

    Case Presentation: A 57 year old Caucasian woman with chronic kidney disease stage five was reviewed in a regional joint renal genetics clinic. Read More

    [Hyperuricemia and gene mutations: a case report].
    G Ital Nefrol 2017 Jun;34(3):38-43
    S.C. Nefrologia e Dialisi ASLCN1, Ospedali di Ceva, Mondoví, Savigliano e Saluzzo.
    Hyperuricemia is frequently found in nephrology. The case presented may be useful to clarify some pathogenetic aspects. It is a patient of 18 years, hyperuricaemic. Read More

    Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.
    Bioorg Med Chem Lett 2017 Jun 23. Epub 2017 Jun 23.
    School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China; Division of Pharmacology Laboratory, National Institutes for Food and Drug Control, Beijing 100050, China. Electronic address:
    This study mainly focused on the modification of the X(2) position in febuxostat analogs. A series of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives (1a-s) with an N atom occupying the X(2) position was designed and synthesized. Evaluation of their inhibitory potency in vitro on xanthine oxidase indicated that these compounds exhibited micromolar level potencies, with IC50 values ranging from 0. Read More

    Serum uric acid is positively associated with pulmonary function in Korean health screening examinees.
    Mod Rheumatol 2017 Feb 21:1-9. Epub 2017 Feb 21.
    c Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , South Korea.
    Objectives: To determine whether level of serum uric acid (SUA) is linked to pulmonary function in health screening examinees without overt medical conditions.

    Methods: We performed a cross-sectional study on 69,928 Koreans that participated in an annual health check.

    Results: Percent predicted forced vital capacity (FVC%) and forced expiratory volume in 1 s (FEV1%) were positively correlated with SUA in both genders (FVC%: r = . Read More

    Hyperuricemia is an independent risk factor for psoriatic arthritis in psoriatic patients.
    J Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
    Psoriatic arthritis (PsA) is a spondyloarthritic condition mainly seen in patients with psoriasis. Psoriatic patients with plaques on the scalp, gluteal fold or nail lesions are known to develop PsA more frequently, but other markers for PsA have not yet been identified. To determine which psoriatic patients are at greatest risk of developing PsA, psoriasis vulgaris (PsV) patients who visited the Department of Dermatology, Fukuoka University Hospital in 2015 were enrolled. Read More

    Current and future therapies for Gout.
    Expert Opin Pharmacother 2017 Jul 10. Epub 2017 Jul 10.
    c Department of Rheumatology, Assistance Publique-Hôpitaux de Paris , Hôpital Lariboisiere , Paris , F-75010 , France .
    Introduction: Gout is a common disease responsible for recurrent flares triggered by the deposition of monosodium urate crystals secondary to longstanding hyperuricaemia. The management of gout implies both the treatment of flares and the treatment of hyperuricaemia itself. Recent improvement in the understanding of the disease led to the development of new drugs. Read More

    A phase I study of cabazitaxel in combination with platinum and 5-fluorouracil (PF) in locally advanced squamous cell carcinoma of head and neck (LA-SCCHN).
    Oral Oncol 2017 Aug 16;71:99-104. Epub 2017 Jun 16.
    Tisch Cancer Institute, Mount Sinai School of Medicine, NYC, NY 10029, United States. Electronic address:
    Background: There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed an excellent response rate compared to docetaxel and might prove useful in treatment of patients. The primary objective of this study was to determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of cabazitaxel when combined with cisplatin and 5-fluorouracil (PF) in induction chemotherapy (IC) for patients with SCCHN. Read More

    [The uric acid cardio-nephropathy].
    G Ital Nefrol 2017 Mar;34(Suppl 69):41-48
    Università degli Studi di Genova, IRCCS A.O.U. San Martino-IST, Genova, Italy.
    Uric acid is a product of purine catabolism formed by the activity of xanthine-oxidase and prevalently excreted by the kidney. In vivo, urate is known to have both an anti- or pro-oxidant role depending on several biological conditions. New evidence suggests that chronic hyperuricemia can contribute to hypertension development, kidney disease and cardiovascular risk. Read More

    Long-lasting response to oral therapy in a young male with monogenic diabetes as part of HNF1B-related disease.
    Endocrinol Diabetes Metab Case Rep 2017 23;2017. Epub 2017 Jun 23.
    Endocrinologists in Complejo Hospitalario Universitario de Albacete, Castilla La ManchaSpain.
    Mutations in hepatocyte nuclear factor 1β gene (HNF1B) are responsible for a multisystemic syndrome where monogenic diabetes (classically known as MODY 5) and renal anomalies, mostly cysts, are the most characteristic findings. Urogenital malformations, altered liver function tests, hypomagnesemia or hyperuricemia and gout are also part of the syndrome. Diabetes in these patients usually requires early insulinization. Read More

    Predictive value of CHADS2 and CHA2DS2-VASc scores for acute myocardial infarction in patients with atrial fibrillation.
    Sci Rep 2017 Jul 5;7(1):4730. Epub 2017 Jul 5.
    Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
    The presence of acute myocardial infarction (AMI) confers a poor prognosis in atrial fibrillation (AF), associated with increased mortality dramatically. This study aimed to evaluate the predictive value of CHADS2 and CHA2DS2-VASc scores for AMI in patients with AF. This retrospective study enrolled 5140 consecutive nonvalvular AF patients, 300 patients with AMI and 4840 patients without AMI. Read More

    Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette sub-family G member 2.
    Am J Physiol Renal Physiol 2017 Jul 5:ajprenal.00012.2017. Epub 2017 Jul 5.
    Teikyo University School of Medicine, Japan.
    Accumulating data indicate that renal uric acid (UA) handling is altered in diabetes and by hypoglycemic agents. In addition, hyperinsulinemia is associated with hyperuricemia and hypouricosuria. However, the underlying mechanisms remain unclear. Read More

    Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.
    Arthritis Res Ther 2017 Jul 5;19(1):161. Epub 2017 Jul 5.
    Biochemistry Department, University of Otago, 710 Cumberland Street, Box 56, Dunedin, 9054, New Zealand.
    Background: Some gout-associated loci interact with dietary exposures to influence outcome. The aim of this study was to systematically investigate interactions between alcohol exposure and urate-associated loci in gout.

    Methods: A total of 2792 New Zealand European and Polynesian (Māori or Pacific) people with or without gout were genotyped for 29 urate-associated genetic variants and tested for a departure from multiplicative interaction with alcohol exposure in the risk of gout. Read More

    Change gout: the need for a new approach.
    Minerva Med 2017 Aug;108(4):341-349
    Unit of Rheumatology, Department of Medicine DIMED, Padua University Hospital, Padua, Italy -
    Gout is the most common form of inflammatory arthropathy and is caused by an excess of uric acid in the blood (hyperuricemia). It is a chronic, debilitating condition that gradually increases in severity and affects an increasing number of people. It has a wide spectrum of clinical manifestations and is related to serious kidney and cardiovascular conditions and to an increased risk of mortality. Read More

    Lipidomics to investigate the pharmacologic mechanisms of ginkgo folium in the hyperuricemic rat model.
    J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jun 20;1060:407-415. Epub 2017 Jun 20.
    School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address:
    Hyperuricemia caused by purine metabolic abnormalities is reported to have close correlation with lipid metabolic disorders. Ginkgo folium, a frequently-used lipid-lowering medicine, has significant anti-hyperuricemia effects. However, it is poorly known about the interaction between lowering uric acid and regulation of lipid metabolic disorders. Read More

    Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options.
    BMC Med 2017 Jul 3;15(1):123. Epub 2017 Jul 3.
    Université Paris Diderot, UFR médicale, Paris, France.
    Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular and renal diseases, and is an independent predictor of premature death. The frequencies of obesity, chronic kidney disease (CKD), hypertension, type 2 diabetes, dyslipidaemias, cardiac diseases (including coronary heart disease, heart failure and atrial fibrillation), stroke and peripheral arterial disease have been repeatedly shown to be increased in gout. Therefore, the screening and care of these comorbidities as well as of cardiovascular risk factors are of outmost importance in patients with gout. Read More

    Recombinant production of Aspergillus Flavus uricase and investigation of its thermal stability in the presence of raffinose and lactose.
    3 Biotech 2017 Jul 30;7(3):201. Epub 2017 Jun 30.
    Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran.
    Aspergillus flavus uricase (Rasburicase) with a molecular mass of 135 kDa is currently used for the treatment of gout and hyperuricemia occurring in tumor lysis syndrome. To characterize the effects of raffinose and lactose osmolytes on the uricase structure, its coding sequence was cloned, expressed in E. coli BL21, and purified by Ni-NTA agarose affinity chromatography. Read More

    Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening in Korean population.
    PLoS One 2017 30;12(6):e0180406. Epub 2017 Jun 30.
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Hyperuricemia is a risk factor for cardiovascular disease and is associated with increased arterial stiffness in high-risk populations. However, given the possible sex-related differences in the prevalence of hyperuricemia, the association between elevated serum uric acid (SUA) level and increased arterial stiffness has yielded conflicting results. We investigated the relationship between SUA and arterial stiffness in asymptomatic healthy subjects who underwent a health examination. Read More

    Diet-independent relevance of serum uric acid for blood pressure in a representative population sample.
    J Clin Hypertens (Greenwich) 2017 Jun 29. Epub 2017 Jun 29.
    DONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Bonn, Germany.
    A direct relationship between serum uric acid and blood pressure (BP) has been reported, but the possible confounding impact of diet on this association is unclear. The authors performed a cross-sectional analysis in the representative German Health Interview and Examination Survey for Adults (n=6788, aged 18-79 years). In adjusted regression models considering dietary factors, each 1-mg/dL higher uric acid value was associated with a 1. Read More

    Updates on the treatment of gout, including a review of updated treatment guidelines and use of small molecule therapies for difficult-to-treat gout and gout flares.
    Expert Opin Pharmacother 2017 Aug 9;18(11):1115-1125. Epub 2017 Jul 9.
    b Department of Pharmacy Practice and Administration , Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey , Piscataway , NJ , USA.
    Introduction: Gout is a rheumatologic condition associated with elevated serum uric acid levels and deposition of monosodium urate crystals in joints and soft tissues. Areas covered: In this article, we describe the role of currently available drug therapies for managing acute gout flares and used in reducing serum urate levels. Further, we explore the role of novel small molecular therapies and biologic agents in the treatment of refractory or severe gout symptoms. Read More

    Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.
    Bioorg Med Chem Lett 2017 Aug 19;27(15):3602-3606. Epub 2017 Jan 19.
    Department of Orthopedics, First Affiliated Hospital, Guangxi Medical University, Nanning, PR China. Electronic address:
    A series of hydroxychalcone derivatives have been designed, synthesized and evaluated for human xanthine oxidase (XO) inhibitory activity. Most of the tested compounds acted moderate XO inhibition with IC50 values in the micromolar rang. Molecular docking and kinetic studies have been performed to explain the binding modes of XO with the selected compounds. Read More

    Higher oxidative stress in skeletal muscle of McArdle disease patients.
    Mol Genet Metab Rep 2017 Sep 9;12:69-75. Epub 2017 Jun 9.
    Department of Pediatrics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
    McArdle disease (MCD) is an autosomal recessive condition resulting from skeletal muscle glycogen phosphorylase deficiency. The resultant block in glycogenolysis leads to an increased flux through the xanthine oxidase pathway (myogenic hyperuricemia) and could lead to an increase in oxidative stress. We examined markers of oxidative stress (8-isoprostane and protein carbonyls), NAD(P)H-oxidase, xanthine oxidase and antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activity in skeletal muscle of MCD patients (N = 12) and controls (N = 12). Read More

    Hypouricemic and nephroprotective effects of total flavonoids from the residue of supercritical CO2 extraction of Humulus lupulus in potassium oxonate-induced mice.
    Pak J Pharm Sci 2017 Mar;30(2):493-497
    Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, PR China.
    Total flavonoids of Humulus lupulus (TFHL) were prepared using ethanol extraction, liquid-liquid partition and purification with polyamide resin. Different dose of TFHL were orally administered to normal and hyperuricemic mice for 7 days. The xanthine oxidase (XOD) inhibitory activity and hypouricemic effects of TFHL on potassium oxonate-induced hyperuricemic mice were examined. Read More

    Diagnosis and treatment for hyperuricaemia and gout: a protocol for a systematic review of clinical practice guidelines and consensus statements.
    BMJ Open 2017 Jun 23;7(6):e014928. Epub 2017 Jun 23.
    Department of Endocrinology and Metabolism 610041, West China Hospital, Sichuan University, Chengdu, China.
    Introduction: Gout and hyperuricaemia are major health issues and relevant guidance documents have been released by a variety of national and international organisations. However, these documents contain inconsistent recommendations with unclear quality profiles. We aim to conduct a systematic appraisal of the clinical practice guidelines and consensus statements pertaining to the diagnosis and treatment for hyperuricaemia and gout, and to summarise recommendations. Read More

    Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.
    Eur J Gastroenterol Hepatol 2017 Jun 21. Epub 2017 Jun 21.
    aDepartment of Internal Medicine, University of Hawaii, Honolulu, HawaiibDepartment of Internal Medicine, Norwalk Hospital, Norwalk, ConnecticutcDepartment of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, New YorkdDepartment of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USAeDepartment of Medicine, King Chulalongkorn Memorial HospitalfDepartment of Medicine, Division of Rheumatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. Read More

    ARISTOLOCHIA BRACTEOLATE RETZ. ATTENUATES HYPERURICEMIA IN A METABOLIC ARTHRITIS RAT MODEL.
    Afr J Tradit Complement Altern Med 2017 5;14(4):180-187. Epub 2017 Jun 5.
    Department of Pediatric Orthopedics, Luoyang Orthopedictraumatological Hospital, Luoyang, Henan, 471000, China.
    Background: The leaves of Aristolochia bracteolata Retz. has been documented in the folk medicine literature for its anti-arthritic activity. The target of the research envisaged was to elucidate the activity of A. Read More

    Prognostic Value of Uric Acid for Pulmonary Thromboembolism.
    Respir Care 2017 Aug 20;62(8):1091-1096. Epub 2017 Jun 20.
    Department of Pulmonary Medicine.
    Background: Pulmonary thromboembolism is a serious cardiovascular condition with considerable morbidity and mortality. Clinical studies have indicated that hyperuricemia is an independent risk factor for cardiovascular events. The aim of this study was to investigate possible value of the serum levels of uric acid (UA) in predicting 30-d pulmonary thromboembolism-related mortality. Read More

    [Independent risk factors for severe cardiovascular events in male patients with gout: Results of a 7-year prospective study].
    Ter Arkh 2017 ;89(5):10-19
    V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; I.N. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
    Aim: To determine risk factors for severe cardiovascular (CV) events (CVEs) in male patients with crystal-verified gout.

    Subjects And Methods: 251 male patients with crystal-verified gout were prospectively followed up in 2003 to 2013. The mean follow-up period was 6. Read More

    Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia.
    Nutr Metab (Lond) 2017 13;14:38. Epub 2017 Jun 13.
    Department of Clinical Chinese Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.
    Background: Excessive production and/or reduced excretion of uric acid could lead to hyperuricemia, which could be a major cause of disability. Hyperuricemia has received increasing attention in the last few decades due to its global prevalence. Cichorium intybus L. Read More

    Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes.
    Sci Rep 2017 Jun 19;7(1):3802. Epub 2017 Jun 19.
    Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.
    Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal females with type 2 diabetes. The overall prevalence of SRC was 18. Read More

    Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats.
    Biomed Pharmacother 2017 Jun 15;93:88-94. Epub 2017 Jun 15.
    Integrative Medicine College, Anhui University of Chinese Medicine, Hefei 230038, China. Electronic address:
    Objective: The current study aimed to investigate whether the saponins, bioactive component of effects of D. collettii, could reduce the serum uric acid level in a hyperuricemic mouse via regulation of urate transporters.

    Methods: Chronic hyperuricemia model was established by combine administration of adenine (100mg/kg) and ethambutol (250mg/kg). Read More

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