7,984 results match your criteria Hyperuricemia


Alterations of Renal Epithelial Glucose and Uric Acid Transporters in Fructose Induced Metabolic Syndrome.

Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,

Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More

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December 2018

Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino-IST, Genova, Italy.

Renal proximal tubular cells (PTECs) participate in several mechanisms of innate immunity, express toll-like receptors (TLRs), and proinflammatory cytokines. Hyperuricemia may be a promoter of inflammation and renal damage. Angiotensin II (Ang II) modulate immune and inflammatory responses in renal tubular cells. Read More

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December 2018

Effect of Laparoscopic Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Patients with Body Mass Index less than 30 kg/m.

Obes Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China.

Background: Laparoscopic sleeve gastrectomy (LSG) has been proved to be the most effective treatment strategy for the treatment of type 2 diabetes mellitus (T2DM) with a body mass index ≥ 30 kg/m achieving high remission rates. However, there are few clinical studies on the treatment of T2DM patients with a body mass index less than 30 kg/m by LSG. This study aims to study the effect of LSG on type 2 diabetes mellitus(T2DM) in patients with a body mass index (BMI) less than 30 kg/m. Read More

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December 2018

Implications of Hyperuricemia in Severe Coronary Artery Disease.

Am J Cardiol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Hyperuricemia has been associated with mortality in patients with coronary artery disease (CAD). However, its prognostic value remains unknown in the context of severe CAD with heavy atherosclerotic burden in all 3 vessels. We used data from a large cohort of consecutive patients with severe CAD. Read More

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November 2018

Mechanistic insights of soluble uric acid-related kidney disease.

Curr Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041. China.

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Read More

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December 2018

Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.

Neurol Res 2018 Dec 11:1-7. Epub 2018 Dec 11.

b Department of Neurology , the first Affiliated Hospital of Harbin Medical University , Harbin , China.

Objectives: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.

Methods: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. Read More

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December 2018

Predictive Value of Hepatorenal Status in Contrast-Induced Nephropathy Among Patients Receiving Coronary Angiography and/or Intervention: A Systematic Review and Meta-Analysis.

Angiology 2018 Dec 9:3319718816206. Epub 2018 Dec 9.

1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background:: Low serum albumin, high blood urea nitrogen (BUN), and uric acid are regarded closely related to the incidence of contrast-induced nephropathy (CIN), whereas it remains unclear whether they can function as predictors of CIN onset. The objective of this systematic review and meta-analysis was to explore the association between abovementioned indicators and CIN incidence rate in patients receiving coronary angiography (CAG) and/or intervention.

Methods:: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and ScienceDirect from their inception to July 13, 2018. Read More

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December 2018

Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1218-1225

Joint Program of Family Medicine, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess knowledge and practice levels in asymptomatic hyperuricemia (AH) and investigate predictors of urate-lowering therapy (ULT) misprescribing among primary health care (PHC) physicians.

Methods: A cross-sectional study was conducted among 201 PHC physicians from December 2017 to May 2018. A based clinical guidelines for hyperuricemia management from American Professional Organizations, a semi-structured questionnaire was administered to collect demographic and professional data; knowledge and practice levels in management of AH; and barriers to the management of hyperuricemia and gout, with focus of the misprescribing of ULT in AH. Read More

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December 2018

Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.

Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More

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November 2018

Relationship Between Uric Acid, Proteinuria, and Atherogenic Index of Plasma in Renal Transplant Patients.

Authors:
Z Biyik I Guney

Transplant Proc 2018 May 29. Epub 2018 May 29.

Health Science University, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

This study aimed to determine the association of atherogenic index of plasma (AIP) with both hyperuricemia and proteinuria in renal transplant recipients.

Material And Methods: Between the years 2015 and 2017, 61 renal transplant recipients with at least 1 year of follow-up were included in this retrospective cohort study. Uric acid levels of ≥7 mg/dL in men and ≥6 mg/dL in women were accepted as hyperuricemia. Read More

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A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:

With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time. The results show PO 200 μM + XSS 10 μM, PO 300 μM + XSS 15 μM, and PO 400 μM + XSS 20 μM can significantly increase the level of uric acid in the zebrafish larvae (P < 0.05), the concentrations as described above can be used to construct the zebrafish larvae model of acute hyperuricemia. Read More

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November 2018

Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address:

Hyperuricemia contributes to vascular injury and dysfunction, yet the potential mechanisms are not well understood. Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Given that MIF is able to induce vascular smooth muscle cell (VSMC) de-differentiation (from contractile state to a secretory state), we thus hypothesized that UA-induced vascular injury is via up-regulating of MIF in VSMCs, which enhancing vascular inflammation and VSMC transition. Read More

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November 2018
1 Read

Independent links between plasma xanthine oxidoreductase activity and levels of adipokines.

J Diabetes Investig 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.

Aims/introduction: Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.

Materials And Methods: The association between plasma XOR activity measured by using liquid chromatography and mass spectrometry and levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) and fibroblast growth factor 21 (FGF21), were investigated in 282 subjects (male/female: 126/156) with no medication of the Tanno-Sobetsu Study. Read More

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December 2018
4 Reads

Effectiveness of healthcare educational and behavioral interventions to improve gout outcomes: a systematic review and meta-analysis.

Ther Adv Musculoskelet Dis 2018 Dec 19;10(12):235-252. Epub 2018 Nov 19.

Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham VA Medical Center, Faculty Office Tower 805B, 510 20th Street South, Birmingham, AL, 35294, USA.

Background: We aimed to systematically review the effectiveness of healthcare behavioral and education interventions for gout patients on clinical outcomes.

Methods: We searched multiple databases to identify trials or observational studies of educational or behavioral interventions in gout. Risk of bias was assessed with the Cochrane tool for randomized control trials (RCTs) and the Newcastle-Ottawa Scale for observational studies. Read More

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December 2018
1 Read

Tumor Lysis Syndrome.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Tumor lysis syndrome (TLS) is an acute, life-threatening disease among adults and children that is associated with the initiation of cytoreductive therapy in the treatment of malignancy. A pattern of metabolic derangements occurs as a result of a massive release of intracellular contents into the systemic circulation. Characteristic findings include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia, and uremia, all of which can lead to cardiac arrhythmia, seizures, renal failure, and sudden death. Read More

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November 2018

Sex-Specific Association between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study.

Endocr Metab Immune Disord Drug Targets 2018 Nov 29. Epub 2018 Nov 29.

Department of Medicine, Hualien Armed Forces General Hospital, Hualien. Taiwan.

Aim: The study was conducted in order to examine the sex-specific association of serum uric acid (SUA) levels with elevated serum alanine aminotransferase (ALT) in a Taiwanese military cohort.

Methods: We made a cross-sectional examination of the sex-specific relationship using 6728 men and 766 women, aged 18-50 years from a large military cohort in Taiwan. SUA levels within the reference range (<7. Read More

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November 2018
2 Reads

Association between hyperuricemia and nontraditional adiposity indices.

Clin Rheumatol 2018 Nov 29. Epub 2018 Nov 29.

Department of Rheumatology, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai, China.

Background: The association between several novel adiposity indices and hyperuricemia is inconclusive. Therefore, we aimed to investigate this association so as to provide theoretical support for the management of hyperuricemia in overweight/obese individuals.

Methods: A cross-sectional study was carried out among 174,698 adults. Read More

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November 2018

Efficacy and tolerability of olive oil-based ketogenic diet in children with drug-resistant epilepsy: A single center experience from Turkey.

Eur J Paediatr Neurol 2018 Nov 20. Epub 2018 Nov 20.

Dokuz Eylul University, Division of Pediatric Metabolism and Nutrition, Izmir, Turkey. Electronic address:

Purpose: Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications of olive oil-based KD in epileptic children.

Method: In this single-center, prospective study, patients were followed up at 1, 3, 6 and 12 months after KD initiation. Read More

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November 2018

Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China.

Ren Fail 2018 Nov;40(1):666-671

a Beilun People's Hospital & the Beilun Branch of the First Affiliated Hospital of School of Medicine , Zhejiang University , Ningbo , Zhejiang , China.

Objective: Uric acid (UA) is a risk marker of CKD and SUA level in CKD 3-4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the risk factors for HN in CKD 3-4 patients.

Methods: The 461 CKD 3-4 patients were recruited and all patients were divided into three groups (24 h UUA normal, underexeret, and overproduct type groups) according to the 24 h UUA level after receiving low purine food for five days. Read More

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November 2018
4 Reads

Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.

Biopharm Drug Dispos 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.

Metformin is always used the baseline antidiabetic therapy of patients with type 2 diabetes mellitus (T2DM) and hyperuricemia. Metformin excreted into urine through active secretion mediated by rOCTs and rMATE1.The aim of this study was to identify the effects of high uric acid on the disposition and its mechanism. Read More

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November 2018
4 Reads

Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death.

World J Gastroenterol 2018 Nov;24(43):4920-4927

Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Aim: To describe the prevalence of posttransplant metabolic syndrome (PTMS) after donation after cardiac death (DCD) liver transplantation (LT) and the pre- and postoperative risk factors.

Methods: One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre- and post-transplantation were collected for both recipients and donors. Read More

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November 2018
1 Read

Production Inhibition and Excretion Promotion of Urate by Fucoidan from in Adenine-Induced Hyperuricemic Mice.

Mar Drugs 2018 Nov 27;16(12). Epub 2018 Nov 27.

College of Food Science & Technology, Guangdong Ocean University, Zhanjiang 524088, China.

This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of the drugs. Serum uric acid, urea nitrogen, hepatorenal functions, activities of hepatic adenosine deaminase (ADA), xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and NF-κB p65 were assessed. Read More

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November 2018
2 Reads

Dietary factors and risk of gout and hyperuricemia: a meta-analysis and systematic review.

Asia Pac J Clin Nutr 2018 ;27(6):1344-1356

Department of Clinical Nutrition, Tianjin Union Medical Center, China.

Background And Objectives: To evaluate the associations of dietary factors and the risk of gout and hyperuricemia.

Methods And Study Design: PubMed and Embase databases were searched from inception to June 2017 for eligible studies. Nineteen prospective cohort or cross-sectional studies with adequate sample sizes are included, all involving red meat, seafoods, alcohol, fructose, dairy products, soy foods, high-purine vegetables and coffee. Read More

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January 2018

Association between vitamin C intake and risk of hyperuricemia in US adults.

Asia Pac J Clin Nutr 2018 ;27(6):1271-1276

Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.

Background And Objectives: The relationship between vitamin C intake and hyperuricemia among the general US adult population has seldom been reported; thus, the present study examined the associations of total vitamin C (dietary vitamin C plus supplementary vitamin C) and dietary vitamin C intake with the risk of hyperuricemia.

Methods And Study Design: Pooled data from three 2-year cycles (2007-2012) of the cross-sectional National Health and Nutrition Examination Survey were used in the present study. Dietary intake data were extracted from two 24-hour dietary recall interviews. Read More

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January 2018

[Renal involvement during monoclonal gammopathies at the teaching hospital of Yopougon in Abidjan, from 2000 to 2016].

Mali Med 2018 ;33(1):6-9

Service de Néphrologie, CHU de Yopougon. Adresse : 21 BP 632 Abidjan 21.

Background: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan.

Methods: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours. Read More

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January 2018
2 Reads

Natural history and risk factors for diabetic kidney disease in patients with T2D: lessons from the AMD-annals.

J Nephrol 2018 Nov 27. Epub 2018 Nov 27.

Università degli Studi and IRCCS Policlinico San Martino-IST, Genoa, Italy.

The Associazione Medici Diabetologi (AMD) annals initiative is an ongoing observational survey promoted by AMD. It is based on a public network of about 700 Italian diabetes clinics, run by specialists who provide diagnostic confirmation and prevention and treatment of diabetes and its complications. Over the last few years, analysis of the AMD annals dataset has contributed several important insights on the clinical features of type-2 diabetes kidney disease and their prognostic and therapeutic implications. Read More

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November 2018
7 Reads

Urate and Osteoarthritis: Evidence For a Reciprocal Relationship.

Joint Bone Spine 2018 Nov 21. Epub 2018 Nov 21.

Rheumatology Section, Department of Medicine, New York Harbor Health Care System, New York Campus, US Department of Veterans Affairs, New York, NY, 10003, USA; Crystal Diseases Study Group, Division of Rheumatology, Department of Medicine, New York University School of Medicine/NYU Langone Health, New York, NY, 10016, USA. Electronic address:

Hyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis. Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient. However, the relationship between the two remains poorly defined. Read More

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November 2018
2 Reads

Epigallocatechin gallate attenuates uric acid-induced injury in rat renal interstitial fibroblasts NRK-49F by up-regulation of miR-9.

Authors:
L-L Chen Y Xu

Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7458-7469

Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Objective: Hyperuricemia is a common symptom in chronic kidney disease (CKD) and uric acid (UA) was observed to be elevated in CKD. Epigallocatechin gallate (EGCG) was reported to have multiple protective functions in inflammatory process. In this study, we investigated the effects of EGCG in UA-treated NRK-49F cells. Read More

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November 2018
3 Reads

Flavanoids and Anthranquinones as Xanthine oxidase and Monoamine oxidase inhibitors: A new approach towards Inflammation and oxidative stress.

Curr Top Med Chem 2018 Nov 20. Epub 2018 Nov 20.

Faculty of Pharmaceutical Sciences, M. D. University, Rohtak. India.

The development of xanthine oxidase and monoamine oxidase inhibitors led to important breakthroughs in the therapy of oxidative damage, hyperuricemia, gout, neurological, neuropsychiatric disorders and management of reperfusion injury. Drugs obtained from natural sources play an important role in treatment of various pathological disorders and act as lead compound for the discovery of new synthetic drug substances. In this review various pharmacological effects produced by inhibition of xanthine oxidase and monoamine oxidase through natural and synthetic flavanoids as well as anthraquinones are discussed in detail. Read More

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November 2018
4 Reads

Efficiency of hyperuricemia correction by low level laser therapy in the treatment of arterial hypertension.

Wiad Lek 2018 ;71(7):1310-1315

Sumy State University, Sumy, Ukraine.

Objective: Introduction: Uric acid (UA) is the risk factors for the development of arterial hypertension (AH). Development of alternative methods of UA level reduction becomes relevant. The aim - to determine the correlation between UA and endothelial dysfunction and blood pressure level (BP), and to evaluate the effectiveness of low level laser therapy (LLLT). Read More

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January 2018
3 Reads

Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women.

Arch Bronconeumol 2018 Nov 13. Epub 2018 Nov 13.

Respiratory Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain.

Objectives: Although an association between uric acid (UA) levels and obstructive sleep apnea (OSA) has been reported, the effect of continuous positive airway pressure (CPAP) on this measure is yet unclear. We aimed to investigate the effect of CPAP therapy on serum UA levels in patients with OSA.

Methods: We conducted a multicenter, open-label, randomized controlled trial in 307 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI]≥15) in 19 Spanish Sleep Units. Read More

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November 2018
6 Reads

Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied?

Environ Toxicol Pharmacol 2018 Dec 26;64:181-186. Epub 2018 Oct 26.

Veterinary Pharmacology/Toxicology, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort, South Africa; University of Pretoria Biotechnology Research Centre, South Africa. Electronic address:

Diclofenac, a non-steroidal anti-inflammatory pharmaceutical agent was responsible for the death of millions of Gyps vulture's in the Indian sub-region with the safety of the other non-steroidal anti-inflammatory drugs (NSAIDs) being questionable. With preclinical safety testing not well established for avian species unlike for mammalian and environmental toxicity, we ask the question if a preclinical model could have predicted the toxic effect of the drug. For this study, we test an Organisation for Economic Co-operation and Development (OECD) guideline 223 for assessing the acute toxic potential of pesticides in birds by exposing three avian species to the drug. Read More

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December 2018
3 Reads

Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats.

Int J Biol Macromol 2018 Nov 13;123:801-809. Epub 2018 Nov 13.

Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

In this present study, we investigated the anti-hyperuricemic and anti-gouty arthritis effect of a puried water-soluble polysaccharide (LJP-1) obtained from Lonicera japonica. A series of characterization of the purified polysaccharide were carried out in this paper. Monosaccharide analysis showed that LJP-1 composed of glucuronic acid, glucose, galactose, arabinose, and xylose at the ratio of 2. Read More

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November 2018
10 Reads

Hyperuricemia-associated Mesoamerican Nephropathy: Case Report and Review of Literature.

Cureus 2018 Sep 11;10(9):e3282. Epub 2018 Sep 11.

Nephrology Unit, Howard University Hospital, Washington, D.C., USA.

Mesoamerican nephropathy (MeN), formerly called chronic kidney disease of unknown cause (CKDu), refers to chronic kidney disease (CKD) that presents in young and middle-aged Central Americans in the absence of any clear etiology. MeN is a relatively new diagnosis with rapidly rising prevalence in specific regions of El Salvador and Nicaragua, Guatemala, and Costa Rica. It is seldom associated with hyperuricemia. Read More

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September 2018
1 Read

Controversies in the treatment of gout.

Vnitr Lek 2018 ;64(7-8):753-761

The authors discuss current options on the treatment of gout (acute gout attack, prophylaxis, management of hypouricemia) and asymptomatic hyperuricemia. They highlight the differences in individual guidelines in terms of the spectrum of drugs used, their preferences, dosing, dose titration, and goals of treatment as well as different positions over asymptomatic hyperuricemia. Further, the authors provide an overview of latest concepts related to uric acid and its association with some neurologic and cardiovascular diseases. Read More

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January 2018
1 Read

Postpartum nephrotic syndrome related to new onset of systemic lupus erythematosus: A case report.

Case Rep Womens Health 2018 Oct 15;20:e00083. Epub 2018 Oct 15.

Second Department of Obstetrics and Gynecology, Aretaieio University Hospital, Vasilissis Sofias 76, Greece.

Postpartum nephrotic syndrome in a pregnant woman with rheumatoid arthritis in long-standing remission is rare. Systemic lupus erythematosus can remain undiagnosed, especially in the absence of clinical manifestations. We present the case of a 34-year-old woman (gravida 2, para 1) who underwent a lower-segment cesarean section at 34 weeks and 6 days of gestation because she had developed preeclampsia and nephrotic syndrome. Read More

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October 2018
6 Reads

Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study.

Dis Markers 2018 23;2018:1236837. Epub 2018 Oct 23.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.

Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and sex-matched apparently healthy people served as controls. Read More

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October 2018
3 Reads

Relation between prognostic impact of hyperuricemia and sympathetic overactivation in patients with heart failure.

J Cardiol 2018 Nov 9. Epub 2018 Nov 9.

Second Department of Internal Medicine, University of Toyama, Toyama, Japan.

Background: Uric acid (UA), which could provide additional prognostic information in patients with heart failure (HF), can activate sympathetic nerve activity and vice versa, thus creating a vicious cycle in the cardiovascular system. However, it remains unclear whether hyperuricemia (UA>7.0mg/dl) can provide prognostic information independent of sympathetic nerve activity. Read More

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November 2018
1 Read

Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway.

Am J Transl Res 2018 15;10(10):3276-3290. Epub 2018 Oct 15.

Laboratory of Children's Kidney Disease, Children's Medical Center, The Second Xiangya Hospital, Central South University Changsha 410000, Hunan, China.

Preglomerular arteriopathy (PA) induced by hyperuricemia contributes to the progression of chronic kidney disease (CKD). Green tea polyphenols (GTPs) are antioxidant ingredients thought to assist in preventing hyperuricemia. However, the underlying mechanism by which GTPs affect renal function remains unclear. Read More

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October 2018
11 Reads

Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.

EBioMedicine 2018 Nov 8;37:259-268. Epub 2018 Nov 8.

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Background: Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also be neuroprotective, and urate-elevating treatment with its precursor inosine is currently under clinical development as a potential disease-modifying strategy for Parkinson's disease (PD). Read More

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November 2018
4 Reads

Gout - An update of aetiology, genetics, co-morbidities and management.

Maturitas 2018 Dec 26;118:67-73. Epub 2018 Oct 26.

University of Queensland School of Clinical Medicine, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Brisbane, Queensland, 4006, Australia. Electronic address:

Gout is an increasingly common chronic disorder of urate crystal deposition that manifests as flares of acute inflammatory arthritis. Hyperuricaemia is a prerequisite and a fifth of both men and woman are hyperuricaemic. The prevalence of gout is much lower than the prevalence of hyperuricaemia for reasons that are not currently clear. Read More

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December 2018
9 Reads

Unravelling the Effect of p,p'-Dichlorodiphenyldichloroethylene (DDE) in Hypertension of Wistar Rats.

J Agric Food Chem 2018 Nov 20. Epub 2018 Nov 20.

CINTESIS , Center for Health Technology and Services Research , Al. Prof. Hernâni Monteiro , 4200-369 Porto , Portugal.

Hypertension is a multifactorial disease with limited knowledge of the involved mechanisms. p,p'-DDE ( p,p'-dichlorodiphenyldichloroethylene) is a pollutant commonly found in tissues that interferes with endocrine signaling. This study aimed to evaluate the mechanism of hypertension triggered by p,p'-DDE exposure in the presence or absence of a HF (high-fat) diet in rats. Read More

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November 2018
12 Reads

Serum Uric Acid Is Independently Associated with Coronary Calcification in an Asymptomatic Population.

J Cardiovasc Transl Res 2018 Nov 9. Epub 2018 Nov 9.

Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, H-1122, Hungary.

Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score is a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with cardiovascular diseases. Read More

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November 2018
4 Reads

The correlation between controlled attenuation parameter and metabolic syndrome and its components in middle-aged and elderly nonalcoholic fatty liver disease patients.

Medicine (Baltimore) 2018 Oct;97(43):e12931

Department of Geriatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

This study aims to investigate the correlation between controlled attenuation parameter (CAP) and metabolic syndrome (MetS) and its components in middle-aged and elderly nonalcoholic fatty liver disease (NAFLD) patients.Middle-aged and elderly patients with NAFLD, who visited our hospital from June 2016 to May 2017, were enrolled as study subjects, whereas middle-aged and elderly patients without liver disease were enrolled as controls in the same period. The prevalence of MetS, MetS components, and the different numbers of MetS components were compared among patients with different CAP values. Read More

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October 2018
6 Reads

Study of the Treatment Effects of Compound Tufuling Granules in Hyperuricemic Rats Using Serum Metabolomics.

Evid Based Complement Alternat Med 2018 16;2018:3458185. Epub 2018 Oct 16.

Department of Traditional Chinese Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.

The study aimed to investigate the mechanism of the effect of Compound Tufuling Granules (CTG) to lower the serum uric acid level in a rat model of hyperuricemia. The rat model was established by administering hypoxanthine through oral gavage and potassium oxonate through intraperitoneal injection. Rats were divided into the normal group, model group, CTG group, and allopurinol group. Read More

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October 2018
3 Reads

Natural Compounds with xanthine oxidase inhibitory activity: A review.

Chem Biol Drug Des 2018 Nov 7. Epub 2018 Nov 7.

Beijing Advance Innovation center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, 100048, China.

Hyperuricemia (HUA), a disease due to an elevation of BUA (body uric acid) level and responsible for various diseases like gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now become a special issue. Previously, we critically discussed the role of dietary polyphenols in the treatment of HUA. Read More

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November 2018
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An Inverse Relationship between Hyperuricemia and Mortality in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis.

J Clin Med 2018 Nov 5;7(11). Epub 2018 Nov 5.

Department of Internal Medicine, Changhua Christian Hospital, Changhua 50006, Taiwan.

The results have been inconsistent with regards to the impact of uric acid (UA) on clinical outcomes both in the general population and in patients with chronic kidney disease. The aim of this study was to study the influence of serum UA levels on mortality in patients undergoing continuous ambulatory peritoneal dialysis. Data on 492 patients from a single peritoneal dialysis unit were retrospectively analyzed. Read More

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November 2018
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Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection.

Nutrients 2018 Nov 2;10(11). Epub 2018 Nov 2.

Department of Gastroenterology, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Zinc deficiency is frequently observed in chronic liver diseases. However, no studies have focused on the zinc status in chronic hepatitis C (HCV)-infected patients receiving direct-acting antiviral agents (DAAs). In this retrospective study, we assessed the serum zinc status in DAA-treated HCV patients with sustained virologic response for over two years (Zn-2y). Read More

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November 2018
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Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.

Psychoneuroendocrinology 2018 Oct 26;101:19-26. Epub 2018 Oct 26.

Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, 4201 SBSG., Irvine, CA, 92697-7085, United States; Department of Acute and Chronic Care, Johns Hopkins University School of Nursing, Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Department of Pediatrics, Johns Hopkins University School of Medicine, 615 North Wolfe St., Baltimore, MD, 21205, United States; Salivary Bioscience Laboratory and Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, 68588-0156, United States.

High levels of uric acid are associated with greater risk of stress-related cardiovascular illnesses that occur disproportionately among African Americans. Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection. The current study examined how salivary uric acid (sUA) is associated with resting and reactive blood pressure - two robust predictors of hypertension and related cardiovascular disease and disparity. Read More

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October 2018
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Myopathies Related to Glycogen Metabolism Disorders.

Neurotherapeutics 2018 Oct;15(4):915-927

Division of Neuromuscular & Neurometabolic Disorders, Departments of Pediatrics and Medicine, McMaster University, Hamilton Health Sciences Centre, Rm 2H26, Hamilton, ON, L8S 4L8, Canada.

Most of the glycogen metabolism disorders that affect skeletal muscle involve enzymes in glycogenolysis (myophosphorylase (PYGM), glycogen debranching enzyme (AGL), phosphorylase b kinase (PHKB)) and glycolysis (phosphofructokinase (PFK), phosphoglycerate mutase (PGAM2), aldolase A (ALDOA), β-enolase (ENO3)); however, 3 involve glycogen synthesis (glycogenin-1 (GYG1), glycogen synthase (GSE), and branching enzyme (GBE1)). Many present with exercise-induced cramps and rhabdomyolysis with higher-intensity exercise (i.e. Read More

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October 2018
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