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    1 OF 148

    Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.
    PLoS One 2017 16;12(11):e0186769. Epub 2017 Nov 16.
    Departments of Urology and Pathology, New York University School of Medicine, New York, New York, United States of America.
    Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys' thick ascending limb (TAL) caused unfolded protein response in younger (1-month old) mice and apoptosis in older (12-month old) mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance. Read More

    Engineering mammalian designer cells for the treatment of metabolic diseases.
    Biotechnol J 2017 Nov 16. Epub 2017 Nov 16.
    Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
    Synthetic biology applies engineering principles to biological systems and has significantly advanced the design of synthetic gene circuits that can reprogram cell activities to perform new functions. The ability to engineer mammalian designer cells with robust therapeutic behaviors has brought new opportunities for treating metabolic diseases. In this review, we highlight the most recent advances in the development of synthetic designer cells uploaded with open-loop gene circuits or closed-loop gene circuits for the treatment of metabolic disorders including diabetes, hypertension, hyperuricemia and obesity, and discuss the current technologies and future perspectives in applying these designer cells for clinical applications. Read More

    Higher triglyceride level predicts hyperuricemia: A prospective study of 6-year follow-up.
    J Clin Lipidol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, P.R. China. Electronic address:
    Background: Despite abundant evidence indicating that higher triglyceride (TG) levels are associated with increased risks of hyperuricemia (HUA), it is unclear whether TG levels can independently predict the incidence of HUA.

    Objective: The aim of the study was to investigate whether TG is an independent risk factor of HUA in a cohort study.

    Methods: We explored the relationship between TG levels and HUA in a dynamic cohort established in 2009. Read More

    [The associations between adenosine triphosphate binding cassette subfamily G member-2 single nucleotide polymorphism and hyperuricemia in a Chinese tertiary hospital faculty cohort].
    Zhonghua Nei Ke Za Zhi 2017 Nov;56(11):833-838
    Division of General Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To investigate gender specific association between single nucleotide polymorphism rs2231142 and hyperuricemia. Method: A matched case-control study was conducted in a faculty cohort of a tertiary hospital in Beijing. The enrollment criteria were faculty member of the hospital with signed consent. Read More

    Uric Acid and the Risks of Kidney Failure and Death in Individuals With CKD.
    Am J Kidney Dis 2017 Nov 10. Epub 2017 Nov 10.
    Renal Division, Brigham & Women's Hospital, Boston, MA.
    Background: Serum uric acid concentrations increase in chronic kidney disease (CKD) and may lead to tubular injury, endothelial dysfunction, oxidative stress, and intrarenal inflammation. Whether uric acid concentrations are associated with kidney failure and death in CKD is unknown.

    Study Design: Prospective observational cohort study. Read More

    Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity.
    J Pharmacol Sci 2017 Oct 31. Epub 2017 Oct 31.
    Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, PR China. Electronic address:
    Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. Read More

    Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases.
    Case Rep Crit Care 2017 11;2017:4141287. Epub 2017 Sep 11.
    Division of Pulmonary-Critical Care Medicine, University of CT Health Center, Farmington, CT 06030, USA.
    Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. Read More

    Diabetic ketoacidosis, hyperuricemia, and encephalopathy intractable to regular-dose insulin.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    .
    Background: Diabetic ketoacidosis (DKA) in children less than 1 year of age is a rare occurrence. Typical presentation includes a prodrome of weight loss and polyuria with subsequent presentation to medical care when acidosis becomes symptomatic.

    Case Presentation: We describe an unusual case of a previously healthy infant with a 3 days' history of constipation, presenting acutely with abdominal pain, lethargy, and dehydration. Read More

    Salivary uric acid and C-reactive protein associations with hypertensionin Midwestern Latino preadolescents and their parents.
    Dev Psychobiol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Human Development and Family Studies, Purdue University, West Lafayette, Indiana.
    Latino families face increased risk for hypertension. Serum-based uric acid and C-reactive protein have been linked to hypertension. However, a paucity of salivary biomarker data exists in this area for Latino families. Read More

    Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
    Mol Genet Genomics 2017 Nov 9. Epub 2017 Nov 9.
    Department of Human Functional Genomics, Advanced Science Research Promotion Center, Organization for the Promotion of Regional Innovation, Mie University, 1577 Kurima-machiya, Tsu, Mie, 514-8507, Japan.
    Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. Read More

    Long-term safety profile of tolvaptan in autosomal dominant polycystic kidney disease patients: TEMPO Extension Japan Trial.
    Drug Healthc Patient Saf 2017 25;9:93-104. Epub 2017 Oct 25.
    Department of Advanced Informatics for Genetic Disease, Juntendo University Graduate School of Medicine, Tokyo.
    Aim: The aim of this trial (ClinicalTrials.gov identifier: NCT01280721) was to investigate the long-term safety profile of tolvaptan in Japanese patients with autosomal dominant polycystic kidney disease (ADPKD).

    Methods: This open-label multicenter trial was conducted to examine adverse drug reactions (ADRs) related to tolvaptan up to an additional 3 years in 135 Japanese patients who participated in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes (TEMPO) 3:4 trial at doses of 60-120 mg/d. Read More

    Hyperuricemia in type 2 diabetic model KK-A(y)/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels.
    BMC Res Notes 2017 Nov 7;10(1):577. Epub 2017 Nov 7.
    Center for Bioscience Research and Education, Utsunomiya University, Mine-machi 350, Utsunomiya, Tochigi, 321-8505, Japan.
    Objective: Hyperuricemia is recognized as a main cause of gout. Accumulating clinical evidence suggests that hyperuricemia is strongly associated with insulin resistance and abnormal glucose metabolism. However, there seem no proper animal models for investigating such associations. Read More

    Asymptomatic hyperuricemia and coronary artery disease in elderly patients without comorbidities.
    Oncotarget 2017 Oct 19;8(46):80688-80699. Epub 2017 Sep 19.
    Department of Nephrology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
    Because many subjects with hyperuricemia have comorbidities, it can be difficult to differentiate the role of hyperuricemia from that of other comorbidities of coronary artery disease (CAD). Subjects aged ≥ 65 years were enrolled in the study and were available at enrollment and at 5-year follow-up. Subjects were excluded if they were overweight or obese, hypertensive, diabetic, hyperlipidemic, had a pre-existing cardiovascular disease, a history of gout or hyperuricemia on medications, or chronic kidney disease as estimated by a glomerular filtration rate (eGFR) < 60 mL/min per 1. Read More

    Lesinurad for the treatment of hyperuricaemia in people with gout.
    Expert Opin Pharmacother 2017 Nov 13:1-7. Epub 2017 Nov 13.
    b Bone & Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences , University of Auckland , Auckland , New Zealand.
    Introduction: Gout is a common form of inflammatory arthritis caused by deposition of monosodium urate crystals. The central strategy for effective long-term management of gout is serum urate lowering. Current urate-lowering drugs include both xanthine oxidase inhibitors and uricosuric agents. Read More

    Prehypertension and high serum uric acid increase risk of arterial stiffness.
    Scand J Clin Lab Invest 2017 Dec 6;77(8):673-678. Epub 2017 Nov 6.
    a Department of Cardio-thoracic Technology, Faculty of Allied Health Sciences , Naresuan University , Phitsanulok , Thailand.
    Prehypertension and serum uric acid are emerging as independent risk factors for arterial stiffness and may also predict cardiovascular diseases. Previous studies have demonstrated the association between serum uric acid and arterial stiffness in hypertensive adults, but there are limited studies in prehypertensive adults. We compared the serum uric acid (SUA) and cardio-ankle vascular index (CAVI) between normotensive and prehypertensive participants. Read More

    Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study.
    J Am Heart Assoc 2017 Nov 4;6(11). Epub 2017 Nov 4.
    University of Alabama, Birmingham, AL.
    Background: Hyperuricemia is associated with hypertension, with elevated serum uric acid levels postulated to have a causal role in the development of hypertension. Consequently, serum uric acid reduction may help lower blood pressure (BP). A Phase 2, double-blind, placebo-controlled trial was conducted to assess the potential BP-lowering effects of the xanthine oxidase inhibitor febuxostat in subjects with hypertension and hyperuricemia (serum uric acid ≥0. Read More

    Relationship of hyperuricemia with low density lipoprotein , liver function tests and markers of systemic inflammation in patients with morbid obesity.
    Gac Med Mex 2017 ;153(Supl. 2):S42-S50
    Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
    Objective: To examine the relationship of uric acid levels with parameters of systemic inflammation, metabolic dysfunction as well as anthropometric parameters and liver function tests in subjects with morbid obesity.

    Methods: C-reactive protein (CRP), tumour necrosis factor-alpha, and interleukin 10 (IL-10) were analyzed in 49 women and men with morbid obesity, relating these markers with uric acid, hepatic function tests, anthropometric and metabolic parameters. Metabolic parameters as serum glucose level, glycosylated hemoglobin, total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein (c-LDL) as well as hepatic function parameters were measured in all subjects. Read More

    Metabonomics study of the effects of traditional Chinese medicine formula Ermiaowan on hyperuricemic rats.
    J Sep Sci 2017 Nov 3. Epub 2017 Nov 3.
    Pharmacology of Chinese Traditional Medicine, College of Pharmacy, Changchun University of Chinese Medicine, Changchun, P. R.China.
    To explore the global mechanism of Ermiaowan on hyperuricemia regulation, the holistic function of Ermiaowan for hyperuricemia in rats was firstly assessed by the urinary metabonomics method which was based on ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. The urinary targeted metabonomics approach combined with the serum biochemical analysis and histological assay was conducted to verify the research result. As a result, the significant differences in metabolic profiles were observed from Ermiaowan-treated group, model group and healthy control group by using multivariate statistical approaches. Read More

    The anti-hyperuricemic effect of epigallocatechin-3-gallate (EGCG) on hyperuricemic mice.
    Biomed Pharmacother 2017 Oct 26;97:168-173. Epub 2017 Oct 26.
    State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, China.
    Epigallocatechin-3-gallate (EGCG), a major constituent of green tea catechin, has been used for antioxidant. This study aimed to evaluate the antihyperuricemic activity of EGCG on hyperuricemic mice. We demonstrated that serum uric acid (UA) level was decreased significantly with dose-dependence by EGCG treated with 10, 20, and 50mg/kg. Read More

    Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation.
    BMC Nephrol 2017 Oct 31;18(1):326. Epub 2017 Oct 31.
    Department of Anatomy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
    Background: Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage. Endothelin-1 (ET-1) is a well-known profibrotic factor in the kidney and is associated with fibroblast expansion. We examined the role of hyperuricemia conditions in causing elevation of ET-1 expression and kidney injury. Read More

    [URATE AS A POTENTIAL RISK FACTOR OF CARDIOVASCULAR AND RENAL DISEASES].
    Acta Med Croatica 2016 12;70(4-5):233-9
    Although asymptomatic hyperuricemia is rather often in laboratory reports, it cannot be considered a disease. Despite the high prevalence of hyperuricemia in patients with arterial hypertension (AH), chronic kidney disease (CKD), cardiovascular disease (CVD) or metabolic syndrome, hyperuricemia is not confirmed as a causative factor of these disorders. The aim is to point to the latest studies of the importance of urate as a possible cardiorenal risk factor. Read More

    Nonalcoholic fatty liver disease: Evolving paradigms.
    World J Gastroenterol 2017 Sep;23(36):6571-6592
    Department of Medical, Surgical, Neurological, Geriatric, and Metabolic Sciences, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
    In the last years new evidence has accumulated on nonalcoholic fatty liver disease (NAFLD) challenging the paradigms that had been holding the scene over the previous 30 years. NAFLD has such an epidemic prevalence as to make it impossible to screen general population looking for NAFLD cases. Conversely, focusing on those cohorts of individuals exposed to the highest risk of NAFLD could be a more rational approach. Read More

    Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease.
    Cochrane Database Syst Rev 2017 10 30;10:CD009460. Epub 2017 Oct 30.
    Department of Renal Medicine and Transplantation, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Cosham, Portsmouth, UK.
    Background: Non-randomised data have shown a link between hyperuricaemia and the progression or development of chronic kidney disease (CKD). If this is correct, urate lowering therapy might form an important part of chronic kidney disease care, reducing risks for cardiovascular outcomes and end-stage kidney disease.

    Objectives: This review aims to study the benefits and harms of uric acid lowering therapy on the progression of CKD and other cardiovascular endpoints. Read More

    Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke.
    Stroke Res Treat 2017 10;2017:1935136. Epub 2017 Sep 10.
    Department of Internal Medicine, Douala General Hospital, Douala, Cameroon.
    Background: Prognostic significance of serum uric acid (SUA) in acute stroke still remains controversial.

    Objectives: To determine the prevalence of hyperuricemia and its association with outcome of stroke patients in the Douala General Hospital (DGH).

    Methods: This was a hospital based prospective cohort study which included acute stroke patients with baseline SUA levels and 3-month poststroke follow-up data. Read More

    A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility.
    Hum Cell 2017 Oct 28. Epub 2017 Oct 28.
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
    Gout is a multifactorial disease characterized by acute inflammatory arthritis, and it is caused as a consequence of hyperuricemia. A recent meta-analysis of genome-wide association studies has newly identified the relationship between serum uric acid (SUA) levels and rs889472, a single nucleotide polymorphism of musculoaponeurotic fibrosarcoma oncogene (MAF/c-MAF). However, it remained unclear whether rs889472 is associated with gout susceptibility. Read More

    Hyperuricemia on Admission Predicts Short-Term Mortality due to Myocardial Infarction in a Population with High Prevalence of Cardiovascular Risk Factors.
    Rev Invest Clin 2017 Sep-Oct;69(5):247-253
    Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
    Background: National health surveys have revealed an outstandingly high prevalence of obesity, hypertension, and diabetes in Mexico.

    Objective: To assess whether serum uric acid levels on admission may predict short-term mortality in patients with ST-segment elevation myocardial infarction in a population with an unusually high prevalence of classic cardiovascular risks.

    Methods: A total of 795 ST-segment elevation myocardial infarction patients undergoing primary reperfusion therapy were classified as having normouricemia or hyperuricemia according to serum uric acid levels at admission, and the occurrence of mortality and major adverse cardiovascular events during coronary care unit stay was assessed. Read More

    The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function.
    Curr Hypertens Rep 2017 Oct 25;19(12):95. Epub 2017 Oct 25.
    Hypertension Research Unit, Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
    Several epidemiological studies have demonstrated the existence of a correlation between high serum uric acid (SUA) levels, hypertension, and chronic kidney disease (CKD). Xantine oxidase inhibitors (XOI) are the most powerful uric acid lowering drugs, with presumed beneficial effects on cardiovascular and renal system. The multifactorial mechanism linking hyperuricemia with cardiovascular and renal diseases involves both the SUA level and the xanthine oxidase (XO) activity. Read More

    A non-randomized, open-label, single-arm, Phase 2 study of emibetuzumab in Asian patients with MET diagnostic positive, advanced gastric cancer.
    Cancer Chemother Pharmacol 2017 Dec 25;80(6):1197-1207. Epub 2017 Oct 25.
    National Cancer Center Hospital East, 5-1, Kashiwanoha 6-chome, Kashiwa, Chiba, 277-8577, Japan.
    Purpose: Mesenchymal-epithelial transition factor (MET) is expressed in gastric cancer and associated with poor clinical outcomes. We assessed activity, safety, and pharmacokinetics of emibetuzumab, a bivalent monoclonal anti-MET antibody that blocks ligand-dependent and ligand-independent MET signaling.

    Methods: This non-randomized, single-arm, Phase 2 study enrolled Asian patients with MET diagnostic positive advanced gastric adenocarcinoma. Read More

    Gender-related association between uric acid, homocysteine, γ-glutamyltransferase, inflammatory biomarkers and metabolic syndrome in subjects affected by obesity.
    Biomark Med 2017 Oct 26. Epub 2017 Oct 26.
    Department of Biomedical, Surgical & Dental Sciences, University of Milan, Milan, Italy.
    Aim: Evaluation of gender-related differences in uric acid (UA), homocysteine and inflammatory biomarkers as metabolic syndrome (MetS) determinants.

    Patients & Methods: Anthropometric and routine data were obtained from 825 obese subjects (591 F, mean age 54 ± 14 years).

    Results: Hyperuricemia was 24% in both genders. Read More

    Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics.
    J Chromatogr B Analyt Technol Biomed Life Sci 2017 Oct 4;1068-1069:149-156. Epub 2017 Oct 4.
    Tea Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong 510640, China; Guangdong Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangzhou, Guangdong 510640, China. Electronic address:
    To evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography-mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Read More

    Predictors of reaching a serum uric acid goal in patients with gout and treated with febuxostat.
    Clinicoecon Outcomes Res 2017 10;9:629-639. Epub 2017 Oct 10.
    Comprehensive Health Insights, Inc., Louisville, KY.
    Purpose: Clinical guidelines recommend febuxostat as first-line pharmacologic urate-lowering therapy for patients with gout to achieve a goal serum uric acid (sUA) <6 mg/dL; however, little is known about other contributing factors. This study identified clinical characteristics of patients treated with febuxostat to develop and validate a predictive model for achieving a goal sUA.

    Patients And Methods: Patients with Humana Medicare or commercial insurance, diagnosed with gout and newly initiated on febuxostat (index date February 1, 2009 - December 31, 2013), were identified for a retrospective cohort study. Read More

    [Hyperuricemia in obese patients with pharmacologically treated essential hypertension].
    Wiad Lek 2017 ;70(2 pt 2):335-339
    Katedra Dietetyki, Wydział Nauk O Żywieniu Człowieka I Konsumpcji, SGGW, Warszawa, Polska.
    Introduction: Hyperuricemia and gout are a growing health problem worldwide. Their etiology is complex, and usually caused by excessive production of uric acid and/or impaired excretion. Some drugs used in the treatment of high blood pressure furthermore increase the risk of hyperuricemia. Read More

    Low-Purine Diet Is More Effective Than Normal-Purine Diet in Reducing the Risk of Gouty Attacks After Sleeve Gastrectomy in Patients Suffering of Gout Before Surgery: a Retrospective Study.
    Obes Surg 2017 Oct 23. Epub 2017 Oct 23.
    Department of Cardio-Thoracic and Respiratory Science, University of Campania "Luigi Vanvitelli", Naples, Italy.
    Background: Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet.

    Objectives: The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty attacks and also whether a postoperative low-purine diet (LPD) may further reduce these attacks as compared to a normal-purine diet (NPD) in a series of patients suffering of gout before SG.

    Methods: In this retrospective study, we measured and compared total body weight (TBW), body mass index (BMI), uric acid levels (UAL), anti-gout medication (allopurinol) requirements, and frequency in gouty attacks in 40 patients that underwent SG and who received either a LPD (n = 24) or NPD (n = 16). Read More

    Erding Formula in hyperuricaemia treatment: unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches.
    J Pharm Pharmacol 2017 Oct 23. Epub 2017 Oct 23.
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
    Objectives: Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula, Erding Formula (EF) and its constituent herbs for a new indication, hyperuricaemia.

    Methods: A hypoxanthine and potassium oxonate-induced hyperuricemic mouse model, a xylene-induced inflammatory mouse model and an acetic acid-induced pain model were used to test the effects of EF and its constituent herbs. Read More

    Aprepitant for the Treatment of Chronic Refractory Pruritus.
    Biomed Res Int 2017 19;2017:4790810. Epub 2017 Sep 19.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Read More

    Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid.
    Ther Adv Endocrinol Metab 2017 Oct 11;8(10):141-146. Epub 2017 Oct 11.
    Hospital General de Ticomán SS DF, Mexican Group for Basic and Clinical Research, Plan de San Luis S/N esq Bandera, México DF CP 07330, México.
    Background: Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid. The aim of this study was to evaluate whether there is a correlation between serum uric acid levels with homeostatic model assessment (HOMA) 1 in nondiabetic patients.

    Methods: We evaluated 88 nondiabetic patients, in whom uric acid levels were measured, in all of them HOMA of β-cell function (HOMA 1B) and HOMA of insulin resistance (HOMA 1IR) scores were performed. Read More

    Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.
    Biomed Pharmacother 2017 Oct 15;96:727-735. Epub 2017 Oct 15.
    State Key Laboratory of Natural Medicines, Tongjia Lane 24#, China Pharmaceutical University, Nanjing 210009, PR China; School of Pharmacy, Tongjia Lane 24#, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:
    Emodinol, 1β, 3β, 23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our Research Group, was identified with apparent uricosuric and nephroprotective effects in hyperuricemia mice in our previous study. This study aimed to investigate the renal protective effect of emodinol in urate nephropathy rats. Rats were orally administrated by combined adenine and ethambutol to induce urate nephropathy. Read More

    Bisphenol A promotes hyperuricemia via activating xanthine oxidase.
    FASEB J 2017 Oct 17. Epub 2017 Oct 17.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
    The prevalence of hyperuricemia has increased rapidly over the past decades. Bisphenol A (BPA) is an environmental endocrine disruptor. We investigated the effects of BPA on uric acid metabolism and its potential mechanisms. Read More

    Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults.
    Lipids Health Dis 2017 Oct 16;16(1):202. Epub 2017 Oct 16.
    The Public Health Center, the First Affiliated Hospital of Chongqing Medical University, 1 Friendship Road, Yuzhong District, Chongqing, NO, China.
    Background: Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects.

    Methods: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. The data included completed anthropometry and blood biochemical indicators and the results of abdominal ultrasound. Read More

    Spontaneous isolated dissection of the superior mesenteric artery and aneurysm formation resulting from segmental arterial mediolysis: a case report.
    Diagn Pathol 2017 Oct 16;12(1):74. Epub 2017 Oct 16.
    Respiratory Medicine, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan.
    Background: Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear.

    Case Presentation: A 57-year-old Japanese man with a history of untreated hypertension and hyperuricemia was admitted to our hospital with the sudden onset of severe epigastric pain. Read More

    A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an Immunomodulatory Effect in C57BL/6J Mice.
    Int J Mol Sci 2017 Oct 16;18(10). Epub 2017 Oct 16.
    School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China.
    Hyperuricemia (HUA) is related to diabetes. Uric acid-induced inflammation and oxidative stress are risk factors for diabetes and its complications. Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. Read More

    Relation of elevated serum uric acid levels to first-degree heart block and other cardiac conduction defects in hospitalized patients with type 2 diabetes.
    J Diabetes Complications 2017 Dec 20;31(12):1691-1697. Epub 2017 Sep 20.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Aims: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM.

    Methods: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Read More

    Impact of Uric Acid Levels on Kidney Disease Progression.
    Am J Nephrol 2017 13;46(4):315-322. Epub 2017 Oct 13.
    Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
    Background: Hyperuricemia is associated with the progression of chronic kidney disease (CKD), but it is not known whether the relationship is causal. We examined the association of hyperuricemia and uric acid lowering therapy (UALT) with progression of CKD in patients with CKD 3 and 4 in the Cleveland Clinic CKD registry.

    Methods: We included 1,676 patients with CKD stages 3 and 4 from Ohio, who had measured their uric acid (UA) levels a year prior to the recording of the second eGFR <60 mL/min/1. Read More

    Design, synthesis and biological evaluation of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors.
    Eur J Med Chem 2017 Dec 27;141:362-372. Epub 2017 Sep 27.
    School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China. Electronic address:
    A series of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives was designed, synthesized and evaluated for inhibitory potency in vitro against xanthine oxidase. The isonicotinamide series was considerably more effective than the nicotinamide series. SARs analysis revealed that the isonicotinoyl moiety played a significant role on the inhibition and that a benzyl ether tail (e. Read More

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