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    Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold.
    Eur J Med Chem 2018 Feb 2;151:849-860. Epub 2018 Feb 2.
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:
    Xanthine oxidase, which catalyzes the oxidative reaction of hypoxanthine and xanthine into uric acid, is a key enzyme to the pathogenesis of hyperuricemia and gout. In this study, for the purpose of discovering novel xanthine oxidase (XO) inhibitors, a series of 2-arylbenzo[b]furan derivatives (3a-3d, 4a-4o and 6a-6d) were designed and synthesized. All these compounds were evaluated their xanthine oxidase inhibitory and antioxidant activities by using in vitro enzymatic assay and cellular model. Read More

    Antigout Effects of : Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method.
    Evid Based Complement Alternat Med 2018 22;2018:1364617. Epub 2018 Feb 22.
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA.
    The XOD inhibitory effects of Plantaginis Semen, that is, the seeds of , and its representative four single compounds, acteoside, 1H-indolo-3-carbaldehyde, isoacteoside, and myristic acid, were evaluated by electron transfer signal blocking activities (ETSBA), which is based on the electron transfer signal of XOD enzymatic reaction. The blocking activities were detected using an electrochemical biosensing method. Compared with control, significant effects were observed after the addition of extract, acteoside, and 1H-indolo-3-carbaldehyde (all < 0. Read More

    Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia.
    Int Heart J 2018 Apr 20. Epub 2018 Apr 20.
    Department of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Kagoshima University.
    Endothelial dysfunction is observed in several cardiovascular diseases, where endothelium-dependent vasodilation is impaired by oxidative stress. However, the time course of endothelial function during the perioperative period of a minor-to-moderate surgery, and the effects of atherosclerotic risk factors and employed general anesthetics on recovery of endothelial function, are unknown. Endothelial function of 30 patients was evaluated as the reactive hyperemia index (RHI) of reactive hyperemia peripheral arterial tonometry. Read More

    Sodium Glucose Co-Transporter 2 Inhibitors: Beyond Glucose Lowering.
    Curr Drug Targets 2018 Apr 19. Epub 2018 Apr 19.
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071. United States.
    Diabetes is an important cause of morbidity and mortality in worldwide. Management of blood glucose is critical for diabetic patients since diabetes carries risk for many diseases and disorders. Although there are several antidiabetic agents in the markets for a long time, some of the agents have dose-limiting side effects, such as hypoglycemia and weight gain which limits their ability to reduce cardiovascular complications. Read More

    Prevalence of metabolic syndrome in China: An up-dated cross-sectional study.
    PLoS One 2018 18;13(4):e0196012. Epub 2018 Apr 18.
    Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou, Guangdong, PR China.
    Metabolic syndrome (MS) is an increasing public health concern because of rapid lifestyle changes. Although there have been previous studies on the prevalence of MS in China, the prevalence may have changed with lifestyle changes over the last decade. To update this prevalence, we performed a cross-sectional survey among adults over 18 years old across China from May 2013 to July 2014. Read More

    Experimental Heat Stress Nephropathy and Liver Injury are Improved by Allopurinol.
    Am J Physiol Renal Physiol 2018 Apr 18. Epub 2018 Apr 18.
    Medicine/Nephrology, University of Colorado, Denver, United States.
    Background: An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be caused by recurrent heat stress and dehydration, and potentially by hyperuricemia. Accordingly, we developed a murine model of kidney injury associated with recurrent heat stress. Read More

    Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study.
    RMD Open 2018 9;4(1):e000647. Epub 2018 Apr 9.
    QPS MRA (Miami Clinical Research), Miami, Florida, USA.
    Objective: Verinurad (RDEA3170) is a high-affinity, selective URAT1 inhibitor in development for treating gout and asymptomatic hyperuricaemia. This study evaluated the pharmacodynamics, pharmacokinetics and safety of verinurad in combination with febuxostat in adults with gout.

    Methods: The phase IIa, open-label, multicentre study randomised 64 subjects into one of five cohorts to receive febuxostat (40 or 80 mg) alone or in combination with verinurad 2. Read More

    4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.
    Phytomedicine 2018 Mar 6;42:9-17. Epub 2018 Mar 6.
    School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, PR China. Electronic address:
    Backgound: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient.

    Purpose: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3). Read More

    Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study.
    Semin Arthritis Rheum 2018 Mar 17. Epub 2018 Mar 17.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
    Objective: This study aims to evaluate whether serum Bisphenol A (BPA) is a risk factor for hyperuricemia.

    Methods: In this prospective study, a total of 482 participants without hyperuricemia were enrolled at baseline and followed up for 6 years. Clinical characteristics were recorded, and serum levels of uric acid and BPA were measured. Read More

    A retrospective study on association between obesity and cardiovascular risk diseases with aging in Chinese adults.
    Sci Rep 2018 Apr 11;8(1):5806. Epub 2018 Apr 11.
    Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
    This study aimed to investigate the prevalence of overweight and obesity and its relationship with cardiovascular risk diseases among different sex and age groups in an urban Chinese adult population. A retrospective analysis was performed on 384,061 Chinese adults aged 20 years and older in Nanjing. The age-standardized prevalence of overweight and obesity was 42. Read More

    Gender-specific association of serum uric acid levels and cardio-ankle vascular index in Chinese adults.
    Lipids Health Dis 2018 Apr 11;17(1):80. Epub 2018 Apr 11.
    The Public Health Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Friendship Road, Yuzhong District, Chongqing, China.
    Background: Little is known about the relationship between serum uric acid (SUA) and cardio-ankle vascular index (CAVI) in Chinese population. Therefore, we aimed to investigate the gender difference in the association of SUA and CAVI in a southwestern Chinese population.

    Methods: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014 in Chongqing. Read More

    A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China.
    Pharmacogenet Genomics 2018 May;28(5):117-124
    Functional Genomics Group, Genomic Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
    Background: Hyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe side effects. HLA-B*5801 is highly associated with the allopurinol-induced toxic epidermal necrolysis and Stevens-Johnson syndrome. Read More

    Renal impairment markers in type 2 diabetic patients with different types of hyperuricemia.
    J Diabetes Investig 2018 Apr 10. Epub 2018 Apr 10.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070, Tianjin, China.
    Aims/introduction: Hyperuricemia (HUA) occurs because of decreased excretion of uric acid, increased synthesis of uric acid, or a combination of both mechanisms. The proportions of these three types of HUA in type 2 diabetic patients are not known. In the mean time, we assume that different types of HUA may manifest with different renal damage even in patients with normal renal filtration function. Read More

    Mean platelet volume at baseline and immune thrombocytopenia relapse in Chinese newly-diagnosed patients: a retrospective cohort study.
    Hematology 2018 Apr 10:1-7. Epub 2018 Apr 10.
    b Department of Hematology , The People's Hospital of Guizhou Province , Guiyang , Guizhou , People's Republic of China.
    Objective In China, the ability of the current immune thrombocytopenia (ITP) guideline to stratify recurrent risk at diagnosis is limited. This study aimed to investigate whether mean platelet volume at diagnosis (MPV) is a risk factor for ITP relapse in Chinese. Methods The present study was a retrospective cohort study. Read More

    Uric acid levels are associated with endothelial dysfunction and severity of coronary atherosclerosis during a first episode of acute coronary syndrome.
    Purinergic Signal 2018 Apr 6. Epub 2018 Apr 6.
    Department of Cardiology, Hopital Nord, Marseille, France.
    The role of serum uric acid in coronary artery disease has been extensively investigated. It was suggested that serum uric acid level (SUA) is an independent predictor of endothelial dysfunction and related to coronary artery lesions. However, the relationship between SUA and severity of coronary atherosclerosis evaluated via endothelial dysfunction using peripheral arterial tone (PAT) and the reactive hyperhemia index (RHI) has not been investigated during a first episode of acute coronary syndrome (ACS). Read More

    Effects of pharmacological reversal of hyperuricemia on features of the metabolic syndrome in patients with gouty arthritis.
    J Investig Med 2018 Apr 4. Epub 2018 Apr 4.
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, and Division of Mineral Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
    Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials. Read More

    [Glycogen storage disease type Ⅰa: a rare cause of gout in adolescent and young adult patients].
    Zhonghua Nei Ke Za Zhi 2018 Apr;57(4):264-269
    Department of General Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    To analyze the clinical features of secondary gout in glycogen storage disease type Ⅰa (GSD Ⅰa), so as to improve the awareness of this disease. The clinical features, laboratory findings, treatments and prognosis of 5 GSD Ⅰa patients with secondary gout who had been admitted to the Peking Union Medical College Hospital during 2006 to 2016 were collected and analyzed. GSD Ⅰa was confirmed by liver biopsy and genotyping. Read More

    [Prevalence of hyperuricemia in the elderly in 7 areas of China].
    Zhonghua Liu Xing Bing Xue Za Zhi 2018 Mar;39(3):286-288
    Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
    To investigate the prevalence of hyperuricemia (HUA) in the elderly in China. A randomized stratified cluster sampling survey was conducted. And 5 376 residents aged ≥60 year in 7 Beijing, Xi'an and Harbin in northern China and Chengdu, Chongqing, Changsha and Shanghai in southern China were surveyed. Read More

    Unmet Needs and the Path Forward in Joint Disease Associated with Calcium Pyrophosphate Crystal Deposition.
    Arthritis Rheumatol 2018 Apr 2. Epub 2018 Apr 2.
    Division of Rheumatology, Allergy and Immunology, VA/UC San Diego, 3350 La Jolla Village Drive, San Diego, CA, 92161.
    Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent, and can be associated with synovitis and joint damage. The older-aged population predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). Read More

    Vancomycin-induced acute kidney injury in elderly Chinese patients: A Single Center Cross-Sectional Study.
    Br J Clin Pharmacol 2018 Apr 1. Epub 2018 Apr 1.
    Department of Pharmacy, Zhongshan Hospital FuDan University, Shanghai, China.
    Aims: Objective was to investigate current situation and risk factors of vancomycin (VAN)-induced acute kidney injury (VI-AKI) in elderly Chinese patients, to assess the outcomes and its risk factors of patients who developed VI-AKI, in order to provide suggestions for improving the prevention and treatment of VI-AKI in elderly Chinese patients.

    Method: We retrospectively identified elderly inpatients that received 4 or more doses of VAN treatment. We compared the VI-AKI with NO-AKI patients. Read More

    Unusual Presentation of Spinal Gout: 2 Cases Report and Literature Review.
    J Orthop Case Rep 2017 Nov-Dec;7(6):50-54
    Department of Orthopaedics and Traumatology, Princess Margaret Hospital, Hong Kong.
    Introduction: Gouty spondyloarthropathy is generally believed to be uncommon. Together with the fact that it can mimic a variety of disease entities, it imposes significant diagnostic challenge in our clinical practice. In this article, we report two patients diagnosed with spinal gout, and both were initially suspected to have a pyogenic infection. Read More

    Efficacy of febuxostat in hyperuricemic patients with mild-to-moderate chronic kidney disease: a meta-analysis of randomized clinical trials: A PRISMA-compliant article.
    Medicine (Baltimore) 2018 Mar;97(13):e0161
    Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University.
    Background: To investigate the efficacy of febuxostat in hyperuricemic patients with chronic kidney disease (CKD), relevant randomized clinical trials (RCTs) were analyzed.

    Methods: We used PubMed, Medline, ISI Web of Science, CBMdisc, and Cochrane Library databases to conduct a systematic literature research. A fixed-effects model was used to evaluate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Read More

    Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.
    Am J Chin Med 2018 Mar 29:1-15. Epub 2018 Mar 29.
    * State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, P. R. China.
    Ethanol and water extracts of Armillaria mellea were prepared by directly soaking A. mellea in ethanol (AME) at 65[Formula: see text]C, followed by decocting the remains in water (AMW) at 85[Formula: see text]C. Significantly, AME and AMW at 30, 60 and 120[Formula: see text]mg/kg exhibited excellent hypouricemic actions, causing remarkable declines from hyperuricemic control (351[Formula: see text][Formula: see text]mol/L, [Formula: see text]) to 136, 130 and 115[Formula: see text][Formula: see text]mol/L and 250, 188 and 152[Formula: see text][Formula: see text]mol/L in serum uric acid, correspondingly. Read More

    Burden of cardio-renal-metabolic conditions in adults with type 2 diabetes within the Diabetes Collaborative Registry.
    Diabetes Obes Metab 2018 Mar 25. Epub 2018 Mar 25.
    AstraZeneca, Gaithersburg, Maryland.
    We examined the prevalence of cardio-renal-metabolic (CaReMe) conditions and their combinations among 530 747 adults with type 2 diabetes in a USA-based outpatient registry of 271 primary care, cardiology and endocrinology offices. We evaluated the following CaReMe conditions: hypertension, hyperlipidaemia, coronary artery disease (CAD), chronic kidney disease (CKD), cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and gout or hyperuricaemia; prevalence estimates were adjusted based on the distribution of diabetes by age in the US population in 2015. We found that it was uncommon for patients to have isolated type 2 diabetes without other CaReMe conditions, with only 6. Read More

    Primary male factor infertility due to asthenospermia in maturity-onset diabetes of the young type 5 (MODY 5): uncommon presentation of an uncommon disease.
    BMJ Case Rep 2018 Mar 23;2018. Epub 2018 Mar 23.
    Department of Medicine, Midnapore Medical College, Midnapore, West Bengal, India.
    Mutations in hepatocyte nuclear factor-1β gene result in a multisystemic syndrome where a monogenic form of diabetes (maturity-onset diabetes of young type 5; MODY 5) and renal anomalies, usually bilateral multiple cysts are the most characteristic findings. Many of them have pancreatic structural abnormalities as well. A plethora of extrapancreatic manifestations like altered liver function tests, hypomagnesaemia, hyperuricaemia with/without gout and urogenital malformations, particularly in females are also components of the syndrome. Read More

    A novel uromodulin mutation in autosomal dominant tubulointerstitial kidney disease: a pedigree-based study and literature review.
    Ren Fail 2018 Nov;40(1):146-151
    a Department of Endocrinology and Metabolism , West China Hospital of Sichuan University , Chengdu , P. R. China.
    Autosomal dominant tubulointerstitial kidney disease caused by mutations in uromodulin gene (ADTKD-UMOD) is a spectrum of hereditary renal disorders, characterized by early-onset hyperuricemia, gout and progressive nephropathy. This study presented a novel UMOD mutation in an ADTKD pedigree and reviewed studies in Chinese population. The index patient is a 16-year-old girl with hypertension, hyperuricemia and normal serum creatinine level. Read More

    Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins.
    Front Endocrinol (Lausanne) 2018 6;9:75. Epub 2018 Mar 6.
    Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.
    Serum uric acid (SUA), as the end product of purine metabolism, has proven emerging roles in human disorders. Here based on a sample of 379 middle and old-aged Chinese twin pairs, we aimed to explore the magnitude of genetic impact on SUA variation by performing sex-limitation twin modeling analyses and further detect specific genetic variants related to SUA by conducting a genome-wide association study. Monozygotic (MZ) twin correlation for SUA level (rMZ = 0. Read More

    The inhibitory effect of some drugs on Candida rugosa Lipase and Pancreatic Human Lipase: In vitro and in silico studies.
    Endocr Metab Immune Disord Drug Targets 2018 Mar 18. Epub 2018 Mar 18.
    Laboratoire des sciences fondamentales, universite Amar Telidji, Laghouat. Algeria.
    Side effects of some drugs may be useful in certain cases. In this work, we studied the inhibitory effects of some medications as: Folic Acid which is taken by pregnant women, Colchicine and Febuxostat which is used as treatment of gout disease. These cases are linked to obesity, where women (BMI ≥ 30) have twice higher odds of having an NTD-affected pregnancy than the normal weight women, and the Gout disease frequently occurs in combination of a Metabolic syndrome. Read More

    Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy.
    Pharmacoeconomics 2018 May;36(5):625-636
    Catholic University of Sacred Heart, Largo Francesco Vito, 1, 00168, Rome, Italy.
    Background: Until very recently the only therapeutic alternative for the management of patients affected by gout/hyperuricemia that did not respond to a first-line treatment based on allopurinol alone or who cannot tolerate allopurinol was febuxostat, a xanthine oxidase non-purine-selective inhibitor. Lately, however, a new therapeutic alternative has become available for the management of this pathology: lesinurad, a urate transporter inhibitor.

    Objective: To objective of this study was to evaluate the cost effectiveness of lesinurad/allopurinol in comparison with febuxostat as a second-line therapeutic strategy for the management of patients affected by gout and hyperuricemia that did not respond to a first-line therapy based on allopurinol alone. Read More

    Identification of monosodium urate crystal deposits in patients with asymptomatic hyperuricemia using dual-energy CT.
    RMD Open 2018 9;4(1):e000593. Epub 2018 Mar 9.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Objectives: Dual-energy CT (DECT) scan is a sensitive and specific tool used to visualise and quantify monosodium urate (MSU) crystal deposits in the joints. Few studies have examined MSU crystal deposits in patients with asymptomatic hyperuricemia (ie, hyperuricemia in the absence of gout) using DECT.

    Methods: We conducted a prospective, non-interventional cross-sectional study to detect MSU crystal deposits on DECT scans among patients with asymptomatic hyperuricemia. Read More

    Change gout: how to deal with this "silently-developing killer" in everyday clinical practice.
    Curr Med Res Opin 2018 Apr 12:1-7. Epub 2018 Apr 12.
    g Clinica Reumatologica , Università Politecnica delle Marche , Ancona , Italy.
    Background: Despite being regarded as an easily-treatable disease, gout diagnosis and management can be challenging.

    Review: This review discusses current issues in gout management and proposes some potential solutions. Gout diagnosis should be reached as early as possible and often requires specific tests, such as synovial fluid analysis or imaging techniques that are not available in most centers, leaving healthcare professionals to rely only on clinical presentations and their experience. Read More

    Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan.
    Int J Cardiol 2018 Jun 13;261:183-188. Epub 2018 Mar 13.
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, CO, USA.
    Background: High serum uric acid (SUA) is associated with the dyslipidemia, but whether hyperuricemia predicts an increase in serum low-density lipoprotein (LDL) cholesterol is unknown. This study is to evaluate whether an elevated SUA predicts the development of high LDL cholesterol as well as hypertriglyceridemia.

    Methods: This is a retrospective 5-year cohort study of 6476 healthy Japanese adults (age, 45. Read More

    Effect of allopurinol on the glomerular filtration rate of children with chronic kidney disease.
    Pediatr Nephrol 2018 Mar 16. Epub 2018 Mar 16.
    Department of Pediatrics, Division of Nephrology, Rush University Medical left, 445 East North Water Street, Suite 1804, Chicago, IL, USA.
    Background: Hyperuricemia is a leading risk factor for the development of chronic kidney disease (CKD). We hypothesized that lowering serum uric acid (SUA) with allopurinol in hyperuricemic children with CKD may reduce the risk of CKD progression.

    Methods: A total of 70 children, aged 3-15 years, with elevated serum uric acid level (SUA) > 5. Read More

    Gout: state of the art after a decade of developments.
    Rheumatology (Oxford) 2018 Mar 13. Epub 2018 Mar 13.
    UFR de Médecine, University of Paris Diderot, USPC, France.
    This review article summarizes the relevant English literature on gout from 2010 through April 2017. It emphasizes that the current epidemiology of gout indicates a rising prevalence worldwide, not only in Western countries but also in Southeast Asia, in close relationship with the obesity and metabolic syndrome epidemics. New pathogenic mechanisms of chronic hyperuricaemia focus on the gut (microbiota, ABCG2 expression) after the kidney. Read More

    The Dietary Fructose:Vitamin C Intake Ratio Is Associated with Hyperuricemia in African-American Adults.
    J Nutr 2018 Mar;148(3):419-426
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
    Background: A high fructose intake has been shown to be associated with increased serum urate concentration, whereas ascorbate (vitamin C) may lower serum urate by competing with urate for renal reabsorption.

    Objective: We assessed the combined association, as the fructose:vitamin C intake ratio, and the separate associations of dietary fructose and vitamin C intakes on prevalent hyperuricemia.

    Methods: We conducted cross-sectional analyses of dietary intakes of fructose and vitamin C and serum urate concentrations among Jackson Heart Study participants, a cohort of African Americans in Jackson, Mississippi, aged 21-91 y. Read More

    Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.
    PLoS One 2018 14;13(3):e0193731. Epub 2018 Mar 14.
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.
    Purpose: Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors.

    Methods: We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Read More

    Development and Validation of a HPLC-UV Method for Extraction Optimization and Biological Evaluation of Hot-Water and Ethanolic Extracts of Dendropanax morbifera Leaves.
    Molecules 2018 Mar 13;23(3). Epub 2018 Mar 13.
    Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan, Jeonnam 58554, Korea.
    Leveille (Araliaceae) has been used in traditional oriental remedies for cancer, inflammation, diabetes, and thrombosis. However, a validated analytical method, standardization, and optimization of extraction conditions with respect to biological activity have not been reported. In this study, a simple and validated HPLC method for identifying and quantifying active substances in was developed. Read More

    Uric Acid Induces Cardiomyocyte Apoptosis via Activation of Calpain-1 and Endoplasmic Reticulum Stress.
    Cell Physiol Biochem 2018 7;45(5):2122-2135. Epub 2018 Mar 7.
    Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
    Background/aims: Hyperuricemia is associated with an increased risk for multiple cardiovascular diseases, but the underlying mechanisms remain largely elusive. Calpain-1 is a protease that is implicated in several pathological conditions that affect the heart. The aim of this current study was to test the effects of uric acid (UA) on cardiomyocyte survival and cardiac function and to investigate the role of calpain-1 in the UA-induced effects in the heart and their underlying mechanisms. Read More

    Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
    J Clin Invest 2018 Apr 23. Epub 2018 Apr 23.
    Department of Biology, Boston University, Boston, Massachusetts, USA.
    Increasing evidence suggests a role for excessive intake of fructose in the Western diet as a contributor to the current epidemics of metabolic syndrome and obesity. Hereditary fructose intolerance (HFI) is a difficult and potentially lethal orphan disease associated with impaired fructose metabolism. In HFI, the deficiency of aldolase B results in the accumulation of intracellular phosphorylated fructose, leading to phosphate sequestration and depletion, increased adenosine triphosphate (ATP) turnover, and a plethora of conditions that lead to clinical manifestations such as fatty liver, hyperuricemia, Fanconi syndrome, and severe hypoglycemia. Read More

    Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with allopurinol in adults with gout: a phase IIa, open-label study.
    RMD Open 2018 8;4(1):e000584. Epub 2018 Feb 8.
    QPS MRA (Miami Clinical Research), Miami, Florida, USA.
    Objectives: Verinurad (RDEA3170) is a high affinity, selective uric acid transporter (URAT1) inhibitor indevelopment for treating gout and asymptomatic hyperuricaemia. This phase IIa study evaluated the pharmacodynamics, pharmacokinetics and safety of verinurad combined with allopurinol versus allopurinol alone in adults with gout.

    Methods: Forty-one subjects were randomised into two cohorts of verinurad (2. Read More

    Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China.
    Sci Rep 2018 Mar 12;8(1):4314. Epub 2018 Mar 12.
    Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
    Hyperuricemia, the physiological prerequisite for gout, is linked to the presence and severity of multiple comorbidities that affect longevity and well-being. By using the baseline data from the China Health and Retirement Longitudinal Study, a nationally representative survey, the prevalence of hyperuricemia in general middle-aged and older Chinese was estimated. The potential effects of health behaviours and comorbidities on hyperuricemia were also explored. Read More

    Hyperuricaemia as a prognostic factor for acute ischaemic stroke.
    Neurologia 2018 Mar 8. Epub 2018 Mar 8.
    Universidad de Las Palmas de Gran Canaria, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Las Palmas de Gran Canaria, España.
    Introduction: Recent studies on uric acid as a biomarker for the prognosis of acute stroke have found conflicting results.

    Methods: We collected blood samples from 600 consecutively admitted patients at our tertiary hospital and analysed the relationship between uric acid levels and functional prognosis (measured using the modified Rankin Scale [mRS]). Patients who had received reperfusion therapy were excluded since this may have influenced uric acid levels. Read More

    The IL-10-1082 (rs1800896) G allele is associated with a decreased risk of developing premature coronary artery disease and some IL-10 polymorphisms were associated with clinical and metabolic parameters. The GEA study.
    Cytokine 2018 Jun 9;106:12-18. Epub 2018 Mar 9.
    Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address:
    Interleukin 10 (IL-10) is an anti-inflammatory cytokine with a protective role in the formation and the development of the atherosclerotic plaque. The aim of the present study was to establish if IL-10 gene polymorphisms are associated with the development of premature coronary artery disease (pCAD) and cardiovascular risk factors in Mexican individuals. Three IL-10 gene polymorphisms [-592C/A (rs1800872), -819C/T (rs1800871), and -1082 A/G (rs1800896)] and IL-10 plasma levels were analyzed in 2266 individuals (1160 pCAD patients and 1106 healthy controls). Read More

    Impact of uric acid levels on the risk of long-term cardiovascular mortality in patients with type 2 diabetes mellitus.
    Endocrinol Diabetes Nutr 2018 Mar 7. Epub 2018 Mar 7.
    Instituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Servicio de Urgencias, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
    Background: Hyperuricemia is associated to cardiovascular disease. However, the contribution of uric acid (UA) to cardiovascular mortality in diabetic patients is controversial.

    Objective: To assess the impact of UA levels on the risk of cardiovascular mortality risk in a cohort of patients with type 2 diabetes mellitus (T2DM). Read More

    Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models.
    Phytomedicine 2018 Mar 6;41:54-61. Epub 2018 Feb 6.
    Center for Medicinal Resources Research, Zhejiang Academy of Traditional Chinese Medicine, 132 Tianmushan Road, Hangzhou 310007, PR China. Electronic address:
    Background: Gnaphalium affine D. Don is a folk medicine of China believed to be efficacious in the treatment of many ailments, including hyperuricemia and gout.

    Purpose: Based on a previous study, we isolated two flavones, luteolin and luteolin-4'-O-glucoside, from G. Read More

    RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
    Biomed Pharmacother 2018 May 22;101:617-626. Epub 2018 Mar 22.
    Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address:
    Recent preclinical and clinical evidence suggests that hyperuricemia (HU) is an independent risk factor for metabolic syndrome, hypertension, cardiovascular disease and chronic kidney disease. Receptor-interacting protein 3 (RIP3) is an important contributor in inducing programmed necrosis, representing a newly identified mechanism of cell death combining features of both apoptosis and necrosis. In our study, RIP3 was strongly expressed in mice with hyperuricemia. Read More

    Hyper-Uricemia and Gouty Access in the Adult Population of the Southeast of Gabon: Biochemical Aspects.
    Diseases 2018 Mar 8;6(1). Epub 2018 Mar 8.
    International Medical Research Center of Franceville (CIRMF), Franceville P.O. Box 769, Gabon.
    Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i. Read More

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