8,201 results match your criteria Hyperuricemia


Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level.

Cardiol J 2019 Apr 17. Epub 2019 Apr 17.

1. 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, 17 Kopernika Street, 31-501 Kraków, Poland.

Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity.

Methods: 109 patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1-2 essential hypertension were included in this study. Read More

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http://dx.doi.org/10.5603/CJ.a2019.0033DOI Listing

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

Commun Biol 2019 8;2:115. Epub 2019 Apr 8.

5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.

Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (<5 × 10) including eight novel loci. Read More

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http://dx.doi.org/10.1038/s42003-019-0339-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453927PMC

The Role of Uric Acid in Acute Kidney Injury.

Nephron 2019 Apr 16:1-9. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.

Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that were attenuated with uric acid lowering therapy with rasburicase, a recombinant urate oxidase. Read More

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http://dx.doi.org/10.1159/000499939DOI Listing

Anti-hyperuricemic property of 6-shogaol via self-microemulsifying drug delivery system in model rats: Formulation design, in vitro and in vivo evaluation.

Drug Dev Ind Pharm 2019 Apr 16:1-42. Epub 2019 Apr 16.

a Department of Pharmaceutics , School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University , Zhenjiang 212013 , People's Republic of China.

The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess the diverse pharmacological activities. However, its poor aqueous solubility usually lead to low bioavailability, and further clinical applications will be greatly discounted. Read More

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http://dx.doi.org/10.1080/03639045.2019.1594885DOI Listing

Benzbromarone as a possible cause of acute kidney injury in patients with urolithiasis: Two case reports.

Medicine (Baltimore) 2019 Apr;98(15):e15214

Department of Nephrology, China-Japan Friendship Hospital, Beijing.

Rationale: Reports of acute kidney injury (AKI) associated with benzbromarone use in patients with hyperuricemia (HUA) are rare so far.

Patient Concerns: We describe 2 unique clinical patterns in which benzbromarone was a possible cause of AKI following self-medication for HUA. In case 1, a 45-year-old man developed AKI after taking 100 mg of benzbromarone. Read More

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http://dx.doi.org/10.1097/MD.0000000000015214DOI Listing
April 2019
3 Reads

A Novel Mutation in a Newborn Baby Leading to Glycogen Storage Disease Type Ia.

Authors:
Dorum S Gorukmez O

Balkan J Med Genet 2018 Dec 31;21(2):55-57. Epub 2018 Dec 31.

Department of Genetics, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.

Glycogen storage disease type Ia (GSD1A) is caused by mutations in the gene. The gene was first cloned in 1993. Since then, many different mutations have been identified leading to this disease. Read More

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http://content.sciendo.com/view/journals/bjmg/21/2/article-p
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http://dx.doi.org/10.2478/bjmg-2018-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454238PMC
December 2018
1 Read

Myotonic Dystrophy-2: Unusual Phenotype Due to a Small CCTG-expansion.

Balkan J Med Genet 2018 Dec 31;21(2):39-43. Epub 2018 Dec 31.

Laboratory for Human Genetics, Vienna, Austria.

Myotonic dystrophy type 2 (MD2) is a multisystem disease, predominantly affecting the proximal limb muscles, eyes, endocrine organs, heart and intestines. Longterm asymptomatic creatine kinase (hyper-CKemia) of more than 20 years duration, in association with hyperlipidemia and diabetes, as a manifestation of MD2 has not been reported. A 52-year-old female with a history of hyper-CKemia since the age of 32 years associated with diabetes, hyperlipidemia and hyperuricemia, developed anginal chest pain and proximal muscle weakness together with clinical myotonia when opening the fists at age 51 years. Read More

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http://content.sciendo.com/view/journals/bjmg/21/2/article-p
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http://dx.doi.org/10.2478/bjmg-2018-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454246PMC
December 2018
1 Read

Novel xanthine oxidase-based cell model using HK-2 cell for screening antihyperuricemic functional compounds.

Free Radic Biol Med 2019 Apr 10;136:135-145. Epub 2019 Apr 10.

School of Food Sciences and Engineering, South China University of Technology, Guangzhou 510641, China; Sino-Singapore International Joint Research Institute, Guangzhou Knowledge City, Huangpu District, Guangzhou, 510663, China. Electronic address:

Hyperuricemia is a metabolic disease caused by disorders of purine metabolism, the prevalence of which has increased worldwide. Here, a cell model for high uric acid production was established in vitro employing cultured human kidney cells (HK-2 cells), and its molecular basis was analyzed using gene expression profile. High performance liquid chromatography (HPLC) was used to monitor the content of metabolites in cell culture media. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.007DOI Listing

Clinical Impact of a Protocolized Kidney Donor Follow-up System.

Transplant Proc 2019 Apr 8;51(3):692-700. Epub 2019 Jan 8.

Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Adequate kidney donor management after donation is increasingly emphasized due to concerns of renal function impairment after nephrectomy with increasing life expectancy. In this study, the clinical impact of a protocolized kidney donor follow-up system by nephrologists was evaluated.

Methods: A total of 427 living kidney donors underwent nephrectomy from January 2010 to December 2014 and were followed for at least 2 years at the Samsung Medical Center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183079
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http://dx.doi.org/10.1016/j.transproceed.2018.10.026DOI Listing
April 2019
2 Reads

Uromodulin-related autosomal-dominant tubulointerstitial kidney disease-pathogenetic insights based on a case.

Clin Kidney J 2019 Apr 12;12(2):172-179. Epub 2018 Nov 12.

Department of Internal Medicine III, University Hospital Jena, Friedrich-Schiller-University, Jena, Germany.

Uromodulin-related autosomal-dominant tubulointerstitial kidney disease (ADTKD-UMOD) is a rare monogenic disorder that is characterized by tubulointerstitial fibrosis and progression of kidney function loss, and may progress to end-stage renal disease. It is usually accompanied by hyperuricaemia and gout. Mutations in the uromodulin gene () resulting in malfunctioning of UMOD are known to be the cause of ADTKD-UMOD, which is assumed to be an endoplasmatic reticulum (ER) storage disease. Read More

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http://dx.doi.org/10.1093/ckj/sfy094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452205PMC
April 2019
1 Read

Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.

J Am Soc Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan;

Background: A family history of urolithiasis is associated with a more than doubling of urolithiasis risk, and a twin study estimating 56% heritability of the condition suggests a pivotal role for host genetic factors. However, previous genome-wide association studies (GWAS) have identified only six risk-related loci.

Methods: To identify novel urolithiasis-related loci in the Japanese population, we performed a large-scale GWAS of 11,130 cases and 187,639 controls, followed by a replication analysis of 2289 cases and 3817 controls. Read More

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http://dx.doi.org/10.1681/ASN.2018090942DOI Listing
April 2019
1 Read

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China.

Ren Fail 2019 Nov;41(1):197-203

a Department of Nephrology , Affiliated Yijishan Hospital, Wannan Medical College , Wuhu , China.

Objective: To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference.

Methods: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Read More

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https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1
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http://dx.doi.org/10.1080/0886022X.2019.1591994DOI Listing
November 2019
2 Reads

Febuxostat administration for the prevention of tumour lysis syndrome: A meta-analysis.

J Clin Pharm Ther 2019 Apr 10. Epub 2019 Apr 10.

Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Athens University Medical School, National and Kapodistrian University of Athens, Athens, Greece.

What Is Known And Objective: Tumour lysis syndrome is an oncological emergency, characterized by rapid cytolysis leading to an abrupt rise of serum uric acid levels. The aim of the present meta-analysis is to evaluate the efficacy and safety of febuxostat as a preventive measure in patients at risk of tumour lysis syndrome development, by comparing it with allopurinol administration.

Methods: MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, Clinicaltrials. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpt.12839
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http://dx.doi.org/10.1111/jcpt.12839DOI Listing
April 2019
2 Reads

Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study.

Monaldi Arch Chest Dis 2019 Mar 27;89(1). Epub 2019 Mar 27.

Highly Specialized Rehabilitation Hospital in Motta Di Livenza, Cardiac Prevention and Rehabilitation Unit.

Serum uric acid (UA) has been shown to be a predictor of cardiovascular (CV) morbidity and mortality, and it may play a role in the pathogenesis of CV disease affecting vascular structure and function. However, there is limited evidence of its specific association with carotid artery stiffness and structure. The aim of our study was to evaluate whether UA is associated with early signs of atherosclerosis, namely local carotid arterial stiffness and intima-media thickening. Read More

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http://dx.doi.org/10.4081/monaldi.2019.1007DOI Listing
March 2019
1 Read

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.

Objective: Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for kidney disease in adults with diabetes, but data in youth are limited. We hypothesized that elevated SUA predicts development of elevated urinary albumin excretion (UAE) and hypertension over time in teens with type 2 diabetes (T2D).

Research Design And Methods: Serum creatinine, cystatin C, SUA, and the urine albumin-to-creatinine ratio (UACR) were assessed in 539 obese youth, ages 12-17 years, with T2D duration <2 years at baseline in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Read More

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http://dx.doi.org/10.2337/dc18-2147DOI Listing
April 2019
1 Read
8.420 Impact Factor

Hyperuricemia and Cardiovascular Disease.

Curr Pharm Des 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmacy, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang. China.

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. Read More

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http://dx.doi.org/10.2174/1381612825666190408122557DOI Listing
April 2019
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Vegetarian diet and risk of gout in two separate prospective cohort studies.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Department of Cardiology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan; Department of Internal Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Backgrounds & Aims: Plant-based diets may target multiple pathways in gout pathogenesis (uric acid reduction and anti-inflammation) while improving gout associated cardiometabolic comorbidities. We aim to prospectively examine the relationship between a vegetarian diet and gout, and to explore if this relationship is independent of hyperuricemia.

Methods: We followed 4903 participants in the Tzu Chi Health Study (Cohort1, recruited in 2007-2009) and 9032 participants in the Tzu Chi Vegetarian Study (Cohort2, recruited in 2005) until end of 2014. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.016DOI Listing
March 2019
3 Reads

Triglyceride-glucose index is a predictor of incident chronic kidney disease: a population-based longitudinal study.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii cho, Kamigyo-ku, Kyoto, 621-8585, Japan.

Background: Insulin resistance is one of the risks of chronic kidney disease (CKD). The triglyceride-glucose index (TyG index) has been suggested as a marker of moderate insulin resistance. We aimed to investigate the association between TyG index and incident CKD. Read More

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http://dx.doi.org/10.1007/s10157-019-01729-2DOI Listing
April 2019
2 Reads

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS One 2019 5;14(4):e0214862. Epub 2019 Apr 5.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of oxonic acid (uricase inhibitor) and adenine (biosynthetic precursor of uric acid). These hyperuricemic rats showed plasma uric acid concentrations of up to 6 mg/dL, which is similar to the serum uric acid level in hyperuricemic humans, with little change of inulin clearance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214862PLOS
April 2019
2 Reads
3.234 Impact Factor

Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.

Int J Endocrinol 2019 28;2019:7545137. Epub 2019 Feb 28.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Objective: Both hyperuricemia and hypertension have important clinical implications, but their relationship in terms of gender and age is still a matter of debate. In this study, we aimed to explore gender- and age-specific differences in this association between hyperuricemia and hypertension in a Chinese population.

Methods: A total of 78596 ostensibly healthy subjects (47781 men and 30815 women) were recruited. Read More

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http://dx.doi.org/10.1155/2019/7545137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421730PMC
February 2019
3 Reads

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study.

BMC Nephrol 2019 Apr 2;20(1):117. Epub 2019 Apr 2.

Cohort Study Team, Center for Cluster Development and Coordination, Foundation for Biomedical Research and Innovation at Kobe, 2-2 Minatojima Minamimachi, Chuo-ku, Hyogo, 650-0047, Japan.

Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD).

Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. Read More

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http://dx.doi.org/10.1186/s12882-019-1291-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446294PMC
April 2019
2 Reads

Hepatocyte-Specific Ablation or Whole Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.

Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Department of Physiology and Pharmacology; West Virginia University, Health Sciences Center, Morgantown, WV

Systemic hyperuricemia (HyUA) in obesity/T2DM facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Here, the effects of hepatocyte-specific ablation of , the gene encoding XOR (HXO) and whole-body pharmacologic inhibition of XOR (febuxostat) on obesity-induced insulin resistance/dyslipidemia were assessed. Deletion of hepatocyte substantially lowered liver and plasma UA concentration. Read More

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http://dx.doi.org/10.2337/db18-1198DOI Listing
April 2019
2 Reads

Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.

Lipids Health Dis 2019 Apr 1;18(1):81. Epub 2019 Apr 1.

Laboratory Medicine Center, Lanzhou University Second Hospital, No. 82 Cuiyingmen Lanzhou, Lanzhou, 730030, Gansu, China.

Background: The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).

Methods: The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. Read More

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http://dx.doi.org/10.1186/s12944-019-1031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444567PMC
April 2019
2 Reads

Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout.

J Immunol 2019 Mar 29. Epub 2019 Mar 29.

Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, China;

Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack. A high level of leptin in plasma is a marker of individuals with obesity. Population studies show that leptin promotes obesity-related arthritis, such as osteoarthritis, but it is unknown whether leptin contributes to gouty arthritis, another form of obesity-related arthritis. Read More

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http://dx.doi.org/10.4049/jimmunol.1801097DOI Listing
March 2019
1 Read

Association between serum uric acid and large-nerve fiber dysfunction in type 2 diabetes: a cross-sectional study.

Chin Med J (Engl) 2019 Mar 27. Epub 2019 Mar 27.

Department of Endocrinology and Metabolism, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing 101200, China.

Background: Large-nerve fiber dysfunction, as assessed by vibration perception threshold (VPT) predicts risks of ulceration, amputation, and mortality in diabetes. Serum uric acid (UA) is closely associated with various metabolic disorders, especially diabetes. Thus, we sought to investigate the clinical relevance of UA to large-nerve fiber dysfunction, among patients with type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.1097/CM9.0000000000000223DOI Listing
March 2019
1 Read

Hyperuricaemia and vascular risk: the debate continues.

Curr Opin Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy.

Purpose Of Review: To update the evidence about the role of elevated levels of uric acid as a risk factor for cardiovascular disease. The review includes the most recent epidemiological evidence as well as the possible mechanisms supporting the interaction between uric acid and cardiovascular, metabolic and renal disease.

Recent Findings: The confirmed role of uric acid as involved in the onset and progression of cardiovascular and metabolic diseases. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000626DOI Listing
March 2019
1 Read

Recent Guidelines for Hypertension.

Circ Res 2019 Mar;124(7):984-986

World Hypertension League/South Asia Office, Apollo Hospitals, and Apollo Medical College, Hyderabad, India (C.V.S.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314789DOI Listing
March 2019
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Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia.

Diabet Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Aim: To investigate the association of urinary glucose excretion with levels of serum uric acid in adults with newly diagnosed diabetes.

Methods: A total of 597 people with newly diagnosed diabetes, confirmed in an oral glucose tolerance test, were included in the present study. The participants were divided into two groups: 142 participants with low urinary glucose excretion and 455 with high urinary glucose excretion. Read More

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http://dx.doi.org/10.1111/dme.13956DOI Listing
March 2019
1 Read

Safety and tolerability of available urate-lowering drugs: a critical review.

Expert Opin Drug Saf 2019 Mar 27:1-11. Epub 2019 Mar 27.

b Medical and Surgical Sciences Department , Alma Mater Studiorum University of Bologna , Bologna , Italy.

Introduction: Urate-lowering therapy (ULT) is the cornerstone of gout management, which is a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus development, and urolithiasis. Since asymptomatic increased serum urate levels are associated with a higher risk of cardiovascular, renal and metabolic disorders, a larger use of ULTs in the general population is expected in the near future. Areas covered: This review will focus on the safety and tolerability profile of the available urate-lowering drugs: xanthine oxidase inhibitors (XOIs), uricosuric agents and injectable uricases. Read More

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http://dx.doi.org/10.1080/14740338.2019.1594771DOI Listing
March 2019
1 Read

Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats.

Clin Exp Hepatol 2019 Mar 20;5(1):65-74. Epub 2019 Feb 20.

Department of Tropical Medicine, Faculty of Medicine, Minia University, Egypt.

Aim Of The Study: Non-alcoholic fatty liver disease (NAFLD) is a challenging health problem. Hyperuricemia is a key player in the pathogenesis of NAFLD. This study investigated the effect of allopurinol (uric acid synthesis inhibitor) in combination with metformin and vitamin E in prevention of fructose induced-fatty liver in rats. Read More

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http://dx.doi.org/10.5114/ceh.2019.83159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431087PMC
March 2019
1 Read

Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.

Mol Nutr Food Res 2019 Mar 5:e1801402. Epub 2019 Mar 5.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, Hubei, P. R. China.

Scope: Conjugated linoleic acid (CLA), a bioactive substance predominantly found in ruminant products, improves insulin resistance and exhibits anti-inflammatory activity. The chief objective of the study is to investigate the effects and potential mechanisms of CLA on high fructose-induced hyperuricemia and renal inflammation.

Methods And Results: Hyperuricemia and renal inflammation are induced in rats by 10% fructose. Read More

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http://dx.doi.org/10.1002/mnfr.201801402DOI Listing
March 2019
2 Reads

Prognostic value of NT-proBNP added to clinical parameters to predict two-year prognosis of chronic heart failure patients with mid-range and reduced ejection fraction - A report from FAR NHL prospective registry.

PLoS One 2019 26;14(3):e0214363. Epub 2019 Mar 26.

Department of Cardiology, University Hospital Brno, Brno, Czech Republic.

Background: According to guidelines, the prognosis of patients with chronic heart failure can be predicted by determining the levels of natriuretic peptides, the NYHA classification and comorbidities. The aim our work was to develop a prognostic score in chronic heart failure patients that would take account of patients' comorbidities, NYHA and NT-proBNP levels.

Methods And Results: A total of 1,088 patients with chronic heart failure with reduced ejection fraction (HFrEF) (LVEF<40%) and mid-range EF (HFmrEF) (LVEF 40-49%) were enrolled consecutively. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435170PMC
March 2019
4 Reads

Associations of hyperuricemia, gout, and UA-lowering therapy with the risk of fractures: a meta-analysis of observational studies.

Joint Bone Spine 2019 Mar 22. Epub 2019 Mar 22.

Division of Orthopedic Surgery, Affiliated Hospital of Qinghai University, 810001, Xining, Qinghai Province, China. Electronic address:

Objective: A systematic review and meta-analysis were conducted to investigate the associations of hyperuricemia, gout, and uric acid (UA)-lowering therapy with the risk of fractures.

Methods: Electronic searches on PubMed, the Cochrane Library, and Embase were conducted from inception to January 2, 2019. Observational studies assessing the effects of hyperuricemia, gout, and UA-lowering therapy on fractures were included in the meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.03.003DOI Listing
March 2019
2 Reads

Maternal serum uric acid and calcium as predictors of hypertensive disorder of pregnancy: A case control study.

Taiwan J Obstet Gynecol 2019 Mar;58(2):244-250

Department of Physiology, U.P. University of Medical Sciences, House No. 168, Kaveri Kunj, Phase II, Kamla Nagar, Saifai, Etawah, Agra, 282005, Uttar Pradesh, India. Electronic address:

Objectives: Compare serum uric acid and calcium levels among normotensive and hypertensive pregnant women, to compare maternal and perinatal outcomes in two groups.

Materials And Methods: Prospective case control study was conducted after ethical approval in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India, over seven months. Total 220 antenatal women ≥34 weeks of gestation with 110 cases having hypertensive disorder of pregnancy and 110 controls with normal blood pressure were compared for maternal uric acid and calcium levels and maternal, perinatal outcomes. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.014DOI Listing
March 2019
1 Read

A meta-analysis of the association between gout, serum uric acid level, and obstructive sleep apnea.

Sleep Breath 2019 Mar 22. Epub 2019 Mar 22.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.

Previous epidemiological investigations have evaluated the association between gout, serum uric acid levels, and obstructive sleep apnea syndrome (OSAS), but with inconsistent results. We conducted this meta-analysis aiming at providing clear evidence about whether OSAS patients have higher serum uric acid levels and more susceptible to gout. Relevant studies were identified via electronic databases from inception to December 17, 2018. Read More

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http://dx.doi.org/10.1007/s11325-019-01827-1DOI Listing
March 2019
1 Read
2.869 Impact Factor

Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia.

Arch Med Sci 2019 Mar 2;15(2):343-349. Epub 2018 Mar 2.

Department of Endocrinology, Xili People's Hospital of Nanshan District, Shenzhen, China.

Introduction: The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia.

Material And Methods: Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated dilation was assessed at baseline, and after 1 year's follow-up the incidence of hypertension was compared between those with and without hyperuricemia. Read More

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http://dx.doi.org/10.5114/aoms.2018.73856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425196PMC
March 2019
2 Reads

A Clinical Score to Predict Severe Acute Kidney Injury in Chinese Patients after Cardiac Surgery.

Nephron 2019 Mar 21:1-10. Epub 2019 Mar 21.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications.

Methods: This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 in our institution established associations between predictor variables and postoperative SAKI from a cohort of 1,692 patients and developed a clinical score that was assessed in a validation cohort of 860 patients. Read More

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http://dx.doi.org/10.1159/000499345DOI Listing
March 2019
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The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients.

Arthritis Res Ther 2019 Mar 20;21(1):77. Epub 2019 Mar 20.

Institute of Rheumatology, Na Slupi 4, 128 50, Prague 2, Czech Republic.

Background: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K) being the most common. In this study, we analyzed the ABCG2 gene in a hyperuricemia and gout cohort focusing on patients with pediatric-onset, i. Read More

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http://dx.doi.org/10.1186/s13075-019-1860-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425717PMC
March 2019
1 Read

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications.

Front Pharmacol 2019 5;10:208. Epub 2019 Mar 5.

Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in cancer like other ABC transporters such as ABCB1 (-glycoprotein). As an efflux pump exhibiting a broad substrate specificity localized on cellular plasma membrane, ABCG2 excretes a variety of endogenous and exogenous substrates including chemotherapeutic agents, such as mitoxantrone and several tyrosine kinase inhibitors. Moreover, in the normal tissues, ABCG2 is expressed on the apical membranes and plays a pivotal role in tissue protection against various xenobiotics. Read More

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http://dx.doi.org/10.3389/fphar.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411714PMC
March 2019
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Uricase and Horseradish Peroxidase Hybrid CaHPO₄ Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia.

J Biomed Nanotechnol 2019 May;15(5):951-965

Currently, there are approximately 170 million hyperuricemia patients in China. Conventional drug therapy has limited clinical benefits and may induce serious side effects. Enzyme replacement therapy has attracted much attention owing to its advantages of strong specificity, small dosage, and remarkable curative effect. Read More

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http://dx.doi.org/10.1166/jbn.2019.2752DOI Listing
May 2019
7 Reads

Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome.

BMC Rheumatol 2018 20;2:17. Epub 2018 Jun 20.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120 USA.

Background: Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. Read More

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http://dx.doi.org/10.1186/s41927-018-0027-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390615PMC
June 2018
1 Read

Hyperuricemia and its related histopathological features on renal biopsy.

BMC Nephrol 2019 Mar 18;20(1):95. Epub 2019 Mar 18.

Renal Department and Nephrology Institute, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Background: Hyperuricemia (HUA) is very common in chronic kidney disease (CKD). HUA is associated with an increased risk of cardiovascular events and accelerates the progression of CKD. Our study aimed to explore the relationship between baseline serum uric acid levels and renal histopathological features. Read More

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http://dx.doi.org/10.1186/s12882-019-1275-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423852PMC
March 2019
2 Reads
1.520 Impact Factor

The association between socioeconomic status and prevalence of chronic kidney disease: A cross-sectional study among rural residents in eastern China.

Medicine (Baltimore) 2019 Mar;98(11):e14822

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

To investigate the prevalence of chronic kidney disease (CKD) among eastern Chinese rural residents and analyze the relationship between socioeconomic conditions and CKD.A cross-sectional survey of 1713 adults, enrolled from 4 villages in the north-central part of Zhejiang province in eastern China was conducted by collecting data on socioeconomic status, physical examination, and laboratory investigations. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000014822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426623PMC
March 2019
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Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population.

BMC Nephrol 2019 Mar 15;20(1):93. Epub 2019 Mar 15.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Read More

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http://dx.doi.org/10.1186/s12882-019-1274-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420755PMC

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine.

BMC Complement Altern Med 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Background: Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and inflammatory effects remains elusive. In the present study, Yokuininto exerts multiple homeostatic action on serum uric acid (sUA) levels by blocking pro-inflammatory cytokine activities and inducing uricosuric function with anti-renal injury functions. Read More

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http://dx.doi.org/10.1186/s12906-019-2469-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419507PMC
March 2019
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Production and Characterization of Recombinant Wild Type Uricase from Indonesian Coelacanth () and Improvement of Its Thermostability by In Silico Rational Design and Disulphide Bridges Engineering.

Int J Mol Sci 2019 Mar 13;20(6). Epub 2019 Mar 13.

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

The ideal therapeutic uricase (UOX) is expected to have the following properties; high expression level, high activity, high thermostability, high solubility and low immunogenicity. The latter property is believed to depend largely on sequence identity to the deduced human UOX (dH-UOX). Herein, we explored uricase (LM-UOX) and found that it has 65% sequence identity to dH-UOX, 68% to the therapeutic chimeric porcine-baboon UOX (PBC) and 70% to the resurrected ancient mammal UOX. Read More

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http://dx.doi.org/10.3390/ijms20061269DOI Listing
March 2019
2 Reads

Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.

PLoS One 2019 14;14(3):e0213786. Epub 2019 Mar 14.

Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

A fixed dose combination of lesinurad and allopurinol has been recently approved by USFDA and EMA for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone. In this study, an ultra-performance hydrophilic interaction liquid chromatography (UPHILIC) coupled with tandem mass spectrometry method was developed and validated for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma. Liquid liquid extraction using ethyl acetate as extracting agent was used for samples extraction procedure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213786PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417734PMC
March 2019
3 Reads

Association Of Non-Alcoholic Fatty Liver Disease With Serum Uric Acid.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):64-66

Department of Surgery, Ayub Medical College Abbottabad, Pakistan.

Background: Non-alcoholic fatty liver disorder is a clinicopathological condition, characterized by macro vesicular steatosis in hepatic cells and metabolic stress related disorders without other causes of chronic hepatic disease. Uric acid is basically a heterocyclic compound of hydrogen, carbon, oxygen and nitrogen. Uric acid is the metabolic end product of purine metabolism. Read More

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March 2019
2 Reads

Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity.

Intern Emerg Med 2019 Mar 13. Epub 2019 Mar 13.

Division of Endocrine and Metabolic Surgery, Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Some evidence suggests a relationship between thyroid dysfunction and uric acid (UA) metabolism, but the potential influential role of thyroid hormones on UA metabolism is still debated. This report was designed to evaluate the influential role of levothyroxine (L-T4) replacement therapy on circulating levels of UA in patients with recent onset post-thyroidectomy subclinical hypothyroidism. Circulating levels of thyroid hormones, UA and other metabolic parameters were assessed in 155 recently thyroidectomized patients (131 females, mean age 51. Read More

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http://dx.doi.org/10.1007/s11739-019-02065-9DOI Listing
March 2019
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Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.

Drugs 2019 Apr;79(5):531-541

Department of Medicine, University of Alabama School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294, USA.

Cardiovascular disease affects more than 90 million Americans. Recent studies support an increased cardiovascular disease risk in inflammatory conditions, such as gout. Increased serum urate levels, or hyperuricemia, are a precursor to gout. Read More

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http://dx.doi.org/10.1007/s40265-019-01081-5DOI Listing
April 2019
5 Reads