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    Chronic tophaceous gout in patients with psoriasis.
    An Bras Dermatol 2017 Jan-Feb;92(1):104-106
    Department of Psoriasis - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
    Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. Read More

    An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia.
    Vasc Health Risk Manag 2017 8;13:23-28. Epub 2017 Feb 8.
    Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
    Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%-4% for gout. As such, early detection and careful management of this pathological condition is required, starting from lifestyle changes (mainly based on a diet low in red meat, sugars, and alcoholic beverages, with increased intake of vegetables, water, and vitamin C sources), adding specific drugs to lead serum uric acid (SUA) levels under the target value of 7 mg/dL. Read More

    Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population.
    J Int Med Res 2017 Feb 12;45(1):254-260. Epub 2017 Jan 12.
    1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
    Objective To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. Methods This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital between October 2013 and November 2014. Hyperuricemia was defined as uric acid ≥416 mmol/l for males and ≥360 mmol/l for females. Read More

    Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.
    J Hepatol 2017 Feb 6. Epub 2017 Feb 6.
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom.
    Background & Aims: Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alcoholic steatohepatitis (NASH). Read More

    Dietary and commercialized fructose: Sweet or sour?
    Int Urol Nephrol 2017 Feb 16. Epub 2017 Feb 16.
    School of Medicine, Koç University, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey.
    Metabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Read More

    Evaluation of Association of Hyperuricaemia with Metabolic Syndrome and Insulin Resistance.
    J Clin Diagn Res 2016 Dec 1;10(12):OC32-OC34. Epub 2016 Dec 1.
    Professor and Head, Department of Internal Medicine, Kasturba Medical College , Mangalore, Karnataka, India .
    Introduction: The prevalence of Metabolic Syndrome (MetS) ranges from <10% to as much as 84% depending on region and composition of the population studied. The MetS is a growing public health problem in the world.

    Aim: To evaluate association of hyperuricaemia with components of MetS and insulin resistance. Read More

    The waist circumference-adjusted associations between hyperuricemia and other lifestyle-related diseases.
    Diabetol Metab Syndr 2017 10;9:11. Epub 2017 Feb 10.
    0000 0004 1762 2738grid.258269.2Department of General Medicine, Juntendo University School of Medicine, Japan Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421 Japan.
    Background: Few studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex.

    Methods: This cross-sectional study included 33,498 Japanese individuals, and was conducted at the Center for Preventive Medicine, NTT Kanto Medical Center, Tokyo, from May 2006 to March 2015. Hyperuricemia was defined as a uric acid level of >7 mg/dl in men; >6 mg/dl in women. Read More

    Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase.
    Onco Targets Ther 2017 2;10:597-605. Epub 2017 Feb 2.
    Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Technische Universitaet Dresden, Dresden.
    Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized by acute renal failure, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. While limited options are available for treating TLS, identifying patients at high risk for developing TLS and prevention in high-risk patients remain an important aspect in the treatment of cancer patients. Read More

    Effects of Cilnidipine on Heart Rate and Uric Acid Metabolism in Patients With Essential Hypertension.
    Cardiol Res 2016 Oct 3;7(5):167-172. Epub 2016 Nov 3.
    Ishpat Cooperative Hospital, Kolkata, India.
    Background: The relation between hypertension and hyperuricemia has been established by epidemiological studies. Calcium channel blockers are one of the first-line drugs for newly diagnosed patients with essential hypertension. Cilnidipine is a new calcium channel blocker acting by blocking both L- and N-type calcium channels. Read More

    Prevalence of Calcified Carotid Artery Atheromas on Panoramic Images of Older Men with Gout: a Descriptive Retrospective Study.
    Dentomaxillofac Radiol 2017 Feb 10:20160406. Epub 2017 Feb 10.
    4 Veterans Affairs Great Los Angeles Healthcare System and an Instructor or Oral and Maxillofacial Surgery, School of Dentistry, University of California Los Angeles, CA.
    Objectives: Given the enhanced risk of ischemic stroke resulting from the direct effects of hyperuricemia on vascular plaque formation seen among older males with gout we sought to determine the prevalence of calcified carotid artery atheromas (CCAA) on their panoramic images.

    Methods: Medical records librarians identified all male patients over age 45 who had a diagnosis of gout and a panoramic image incidentally obtained between 2000-2015. The prevalence rate of CCAA on technically appropriate images was determined as were these patients' atherogenic risk profiles including: age, BMI, hypertension, dyslipidemia. Read More

    Endothelial dysfunction in normoglycaemic first-degree relatives of type 2 diabetes mellitus complicated with hyperuricaemia.
    Diab Vasc Dis Res 2017 Mar 21;14(2):88-93. Epub 2016 Dec 21.
    Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, China.
    Objective: To reveal the effect of hyperuricaemia on endothelial function in normoglycaemic first-degree relatives of type 2 diabetes mellitus.

    Methods: In all, 40 first-degree relatives of type 2 diabetes mellitus with hyperuricaemia, 40 first-degree relatives of type 2 diabetes mellitus with normouricaemia and 35 healthy subjects without diabetic family history were recruited in this study. Anthropometric parameters as well as blood pressure, blood lipids, fasting blood glucose, fasting insulin, C-reactive protein, tumour necrosis factor-α and interleukin-6 were measured. Read More

    Association between the hypertriglyceridemic waist phenotype and hyperuricemia: a cross-sectional study.
    Clin Rheumatol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
    The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hyperuricemia. We undertook a cross-sectional study with a sample of 11,576 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Read More

    Prevalence and determinants of left ventricular geometric abnormalities in hypertensive patients: A study based on the updated classification system of left ventricular geometry.
    Hellenic J Cardiol 2017 Feb 4. Epub 2017 Feb 4.
    Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China. Electronic address:
    Aim: The aim of this study was to determine whether different risk factors were associated with different type of left ventricular (LV) geometric abnormalities.

    Methods: This retrospective analysis included 2290 hypertensive participants without other cardiovascular disease, valve disease and with ejection fraction≥50%. The type of LV geometric abnormality was defined on the basis of the new classification system. Read More

    A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study.
    Medicine (Baltimore) 2017 Feb;96(6):e5957
    aDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing bDepartment of Health Care and Geriatrics, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou, Gansu Province, China.
    Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively. Read More

    Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort.
    Clin Rheumatol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Rheumatology and Immunology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
    Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate. To determine the association between serum uric acid and risk of hypertension in the Chinese population, we conducted a prospective study using the "Kailuan Corporation cohort." A total of 39,233 adult subjects with available data on serum uric acid were enrolled from 2006 to 2007. Read More

    Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet.
    Sci Rep 2017 Feb 7;7:41604. Epub 2017 Feb 7.
    Department of Laboratory Medicine, Changhai Hosipital, Second Millitary Medical University, Shanghai 200433, China.
    Given the adverse effects of drugs used for NAFLD treatment, identifying novel and effective natural compound to prevent NAFLD is urgently needed. In the present study, the effects of phytosterol esters (PSEs) on NAFLD were explored. Adult SD rats were randomized into five groups: normal chow diet (NC), high-fat diet (HF), low-, medium- and high-dose PSE treatment plus high-fat diet groups (PSEL, PSEM, and PSEH). Read More

    Metabolic syndrome and the hepatorenal reflex.
    Surg Neurol Int 2016 15;7:99. Epub 2016 Nov 15.
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA.
    Insufficient hepatic O2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in the stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. This theoretical concept is supported by experimental results in animals fed a high fructose diet to induce MetS. Read More

    Synthesis, characterization and xanthine oxidase inhibition of Cu(II)-chrysin complex.
    Spectrochim Acta A Mol Biomol Spectrosc 2017 Jan 31;178:71-78. Epub 2017 Jan 31.
    School of Biological Sciences, The University of Auckland, Auckland 1142, New Zealand.
    Xanthine oxidase (XO) is a key enzyme catalyzing hypoxanthine to xanthine and then uric acid causing hyperuricemia. A Cu(II) complex of chrysin was synthesized and characterized by UV-vis absorption, Fourier transform infrared, nuclear magnetic resonance ((1)H NMR) and mass spectroscopy studies. The interaction of Cu(II)-complex with XO was investigated by spectroscopic methods and molecular simulation. Read More

    Independent Association between Hyperuricemia and Histopathological Parameters in Chinese Patients with Henöch-Schönlein Purpura Nephritis.
    Clin Lab 2016 Nov;62(11):2271-2275
    Background: This study aimed to investigate the role of hyperuricemia in the development of histopathological changes in HSPN.

    Methods: Clinical and laboratory data pertaining to 139 adult HSPN patients with and without elevated serum uric acid levels were retrospectively evaluated. There was a 14. Read More

    Lesinurad: A significant advancement or just another addition to existing therapies of gout?
    J Pharmacol Pharmacother 2016 Oct-Dec;7(4):155-158
    Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
    Gout is a metabolic disorder that usually presents as recurrent episodes of acute arthritis due to deposition of crystals in joints and cartilages. Despite the availability of several drugs for gout, its management is still less than adequate. There is always a search for newer, safer, and more potent urate-lowering therapies for treating patients inadequately controlled with available drugs. Read More

    Cardiovascular morbidity and mortality after liver transplantation: The protective role of Mycophenolate Mofetil.
    Liver Transpl 2017 Feb 3. Epub 2017 Feb 3.
    Liver Unit, Clinica Universidad de Navarra, CIBERehd and Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona.
    Cardiovascular (CV) diseases are recognized long-term causes of death after liver transplantation (LT). The objective of this multicenter study was to analyse the prevalence and the evolution of CV risk factors and CV morbidity and mortality in 1819 liver transplant recipients along 5 years after LT. The influence of baseline variables on survival, morbidity and mortality was studied. Read More

    Gout - a guide for the general and acute physicians.
    Clin Med (Lond) 2017 Feb;17(1):54-59
    University of Nottingham, Nottingham, UK.
    Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase - eg allopurinol, febuxostat - or by increasing the renal excretion of uric acid. Read More

    Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT).
    Am J Clin Nutr 2017 Feb 1. Epub 2017 Feb 1.
    National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China;
    Background: The effect of folic acid supplementation on uric acid (UA) concentrations is still inconclusive.

    Objective: We aimed to test the efficacy of folic acid therapy in reducing serum UA in hypertensive patients.

    Design: A total of 15,364 hypertensive patients were randomly assigned to a double-blind daily treatment with a single tablet that contained 10 mg enalapril and 0. Read More

    Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China.
    BMC Neurol 2017 Feb 1;17(1):21. Epub 2017 Feb 1.
    Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
    Background: Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further complicate the assessment of the correlation. We aimed to investigate SUA in predicting the prognosis of acute stroke in different glycometabolism status.

    Methods: A total of 2907 patients aged from 18 to 85 (1220 diabetes mellitus (DM), 777 prediabetes and 910 normoglycemia) were selected from the Abnormal Glucose Regulation in Patients with Acute Stroke across China (ACROSS-China) study. Read More

    [The values of cardio-ankle vascular and ankle-brachial indices in patients with carbohydrate metabolic disorders: The ESSE-RF study in the Kemerovo Region].
    Ter Arkh 2016 ;88(12):11-20
    Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
    Aim: To investigate factors associated with pathological cardio-ankle vascular and ankle-brachial indices (CAVI and ABI) in patients with carbohydrate metabolic disorders (CMD).

    Subjects And Methods: A cross-sectional study was conducted in the framework of the multicenter epidemiological study "Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Russian Federation" (ESSE-RF) in March to October 2013. The standard ESSE-RF protocol was extended by an additional study of peripheral arterial stiffness, by estimating CAVI and ABI automatically. Read More

    Association between serum uric acid concentrations and grip strength: Is there effect modification by age?
    Clin Nutr 2017 Jan 17. Epub 2017 Jan 17.
    Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid/IdiPaz, Madrid, Spain; CIBER of Epidemioloy and Public Health (CIBERESP), Madrid, Spain.
    Background: Given that some of the deleterious effects of uric acid (UA) on health are greater in younger than in older subjects, and that age is strongly associated with skeletal muscle composition and function, this study tested the hypothesis that the association between UA and muscle strength differs by age.

    Methods: Cross-sectional analysis with 3595 individuals who participated in NHANES 2011-2012. Serum uric acid was determined by the uricase-peroxidase technique. Read More

    Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney transplant patients: A systematic-review and meta-analysis.
    Complement Ther Med 2017 Feb 21;30:84-92. Epub 2016 Dec 21.
    Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:
    Objectives: Cordyceps sinensis (cordyceps) is a fungus used in traditional Chinese medicine as adjuvant immunosuppressive agent in patients with kidney transplant. This review evaluates current evidence on the efficacy and safety of natural and fermented cordyceps preparations in patients with kidney transplant.

    Methods: English and Chinese electronic databases including The Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, and CNKI (China National Knowledge Infrastructure) were searched up to December 2015 for relevant randomized controlled trials. Read More

    Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.
    Molecules 2017 Jan 27;22(2). Epub 2017 Jan 27.
    Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
    The enzymes called ribosome-inactivating proteins (RIPs) that are able to depurinate  nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline  research field, mostly because of their promising medical applications. The contributions of Stirpe  to the development of these studies has been one of the most relevant. After a short biographical  introduction, an overview is offered of the main results obtained by his investigations during last  55 years on his main research lines: hyperuricaemia, xanthine oxidoreductase and RIPs. Read More

    2-Benzamido-4-methylthiazole-5-carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers.
    Arch Pharm (Weinheim) 2017 Feb 30;350(2). Epub 2017 Jan 30.
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Hamdard University, New Delhi, India.
    The new chemical entities febuxostat and topiroxostat have been approved by the US Food and Drug Administration, opening new avenues for exploiting different heterocycles other than purines as xanthine oxidase (XO) inhibitors. A different series of substituted 2-benzamido-4-methylthiazole-5-carboxylic acid derivatives (5a-r) was synthesized and characterized by the collective use of IR, (1) H and (13) C NMR, and mass spectroscopy, for the treatment of gout and hyperuricemia. In vitro studies of the synthesized derivatives revealed that the presence of a fluoro group at the para position in 5b (IC50 = 0. Read More

    Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors.
    Bioorg Med Chem Lett 2017 Feb 16;27(4):729-732. Epub 2017 Jan 16.
    School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China. Electronic address:
    A series of (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety were synthesized and identified as novel xanthine oxidase inhibitors. Among them, the most promising compounds 1h and 1k were obtained with IC50 values of 0.6μM and 0. Read More

    Hyperuricemia as an independent risk factor for major cardiovascular events: a 10-year cohort study from Southern Italy.
    J Cardiovasc Med (Hagerstown) 2017 Mar;18(3):159-164
    aUnità Operativa di Cardiologia ed UTIC - Ospedale "G.Fucito", Mercato S. Severino - Azienda Ospedaliera Universitaria di SalernobCanopo Centro Studi, Salerno, Italy.
    Aims: To date, whether hyperuricemia may represent a marker or an independent risk factor for cardiovascular disease remains unclear. This study aimed at assessing the role of hyperuricemia in the onset of major cardiovascular events (MACE).

    Methods: Baseline clinical data were collected through a 1998/1999 longitudinal survey as part of the larger Valle dell'Irno Prevenzione Project. Read More

    [Uric acid as a risk factor for cardiovascular diseases].
    Vnitr Lek 2016 ;62(11):919-923
    According to current knowledge, uric acid plays an important role in pathogenesis of civilizational diseases - obesity, metabolic syndrome and cardiovascular diseases. Uric acid has become an independent risk factor of morbidity and mortality. It is questionable, if the relationship between uric acid and cardiovascular diseases is direct (through influence on endothelial dysfunction, oxidative stress and inflammation) or indirect (mediated by known risk factors of cardiovascular diseases - metabolic syndrome, obesity, insulin resistance and hypertension). Read More

    Regular physical activity prevents development of hypertension in young people with hyperuricemia.
    J Hypertens 2017 Jan 23. Epub 2017 Jan 23.
    aDepartment of Medicine, University of Padova, Padova bEmergency Area, Town Hospital, San Daniele del Friuli cDepartment of Medicine, Town Hospital, Cremona, Italy.
    Objective: The association of serum uric acid (SUA) with risk of hypertension is controversial and may be modulated by lifestyle factors. We did a prospective study to investigate whether SUA was an independent predictor of hypertension in the young and whether physical activity influences this association.

    Methods: The study was conducted in a cohort of 1156 young to middle-age participants screened for stage 1 hypertension and followed for a median of 11. Read More

    Effect of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi compatibility on uric acid metabolism and urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in rats with hyperuricemia.
    Chin J Integr Med 2017 Jan 24. Epub 2017 Jan 24.
    College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
    Objective: To explore the effects of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi compatibility (PR) on uric acid metabolism and the expression of urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in rats with hyperuricemia.

    Methods: Seventy male Sprague Dawley (SD) rats were randomly divided into 7 groups with 10 rats per group, including the normal group, model group, allopurinol group, benzbromarone group and PR groups at 3 doses (3.5, 7, 14 g/kg). Read More

    Uric Acid, Vascular Stiffness, and Chronic Kidney Disease: Is There a Link?
    Blood Purif 2017 Jan 24;43(1-3):189-195. Epub 2017 Jan 24.
    Controversy exists with regard to the causal role of hyperuricemia in chronic kidney disease. Vascular stiffness may be the link that explains the relation between hyperuricemia and kidney disease. Hyperuricemia is associated with a number of effects on the vascular endothelium and vascular smooth muscle cells, including an increase in oxidative stress, production of vasoconstrictors, and changes on the structural properties of the large artery wall. Read More

    Total Antioxidant Capacity in beta-thalassemia: A systematic review and meta-analysis of case-control studies.
    Crit Rev Oncol Hematol 2017 Feb 8;110:35-42. Epub 2016 Dec 8.
    Center of Nutrition, Council for Agricultural Research and Economics (CREA-NUT), Rome, Italy. Electronic address:
    Total Antioxidant Capacity (TAC), a biomarker measuring the antioxidant potential of body fluids, including redox synergistic interactions, is influenced by the presence of products of catabolism such as bilirubin (BR) and uric acid (UA). Hyperuricaemia and increased BR levels were observed in thalassemia. In order to evaluate the differences in TAC values between thalassemic patients and healthy subjects, we performed a systematic review and meta-analysis of case-control studies. Read More

    Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini-Review.
    PLoS One 2017 20;12(1):e0170393. Epub 2017 Jan 20.
    Division of Nephrology and Kidney Institute, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
    Background: Increasing evidence supports the association between hyperuricemia and incident chronic kidney disease (CKD); however, there are conflicting data regarding the role of hyperuricemia in the progression of CKD. This study retrospectively assessed the longitudinal association between uric acid (UA) level and CKD progression in a Chinese population lived in Taiwan.

    Methods: Patients with physician diagnosis of hyperuricemia or receiving urate-lowering therapy between 2003 and 2005 were identified in the electronic medical records (EMR) of a tertiary medical center and were followed up until December 31, 2011. Read More

    Prevalence and Correlates of Metabolic Syndrome in Chinese Children: The China Health and Nutrition Survey.
    Nutrients 2017 Jan 18;9(1). Epub 2017 Jan 18.
    Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing 100191, China.
    Metabolic syndrome (MetS) is generally defined as a cluster of metabolically related cardiovascular risk factors which are often associated with the condition of insulin resistance, elevated blood pressure, and abdominal obesity. During the past decades, MetS has become a major public health issue worldwide in both adults and children. In this study, data from the China Health and Nutrition Surveys (CHNS) was used to assess the prevalence of MetS based on both the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) guidelines and the International Diabetes Federation (IDF) criteria, and to evaluate its possible correlates. Read More

    Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects.
    Front Pharmacol 2016 5;7:527. Epub 2017 Jan 5.
    Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityBangkok, Thailand; Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, Ramathibodi HospitalBangkok, Thailand.
    Background: Atypical antipsychotics have been found to be associated with hyperuricemia. Risperidone, one of the atypical antipsychotics, might be related to the hyperuricemia among autism spectrum disorder (ASD) patients. The aims of this study were to determine the prevalence of hyperuricemia in ASD patients treated with risperidone and to determine associations between serum uric acid levels and risperidone dosage, treatment duration, and metabolic parameters. Read More

    Hyperuricemia and Acute Renal Failure in Renal Transplant Recipients Treated With High-Dose Mizoribine.
    Transplant Proc 2017 Jan - Feb;49(1):73-77
    Surgery, Omihachiman Community Medical Center, Omihachiman, Japan.
    Background: Hyperuricemia is a common adverse event frequently found in renal transplant recipients with mizoribine (MZ). Hyperuricemia itself will be a cause of renal dysfunction, and renal dysfunction also will be a cause of hyperuricemia simultaneously. This study investigates frequency of hyperuricemia and renal failure in renal transplant recipients treated with high-dose MZ. Read More

    Comparison of Mizoribine and Mycophenolate Mofetil With a Tacrolimus-Based Immunosuppressive Regimen in Living-Donor Kidney Transplantation Recipients: A Retrospective Study in China.
    Transplant Proc 2017 Jan - Feb;49(1):26-31
    Institute of Liver Transplantation, General Hospital of Chinese People's Armed Police Force, Beijing, China; Organ Transplantation Center, Tianjin First Center Hospital, Tianjin, China.
    Background: A retrospective study was conducted to investigate the prevalence of gastrointestinal (GI) symptoms as well as the efficacy and safety of mizoribine (MZR) and mycophenolate mofetil (MMF) in Chinese living-donor kidney transplantation (LDKT).

    Methods: Forty-two recipients enrolled between January 2012 and March 2014 were treated with either MZR (n = 22) or MMF (n = 20). All patients were treated in combination with a tacrolimus-based immunosuppressive regimen, besides the study drugs. Read More

    Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice.
    Cytotechnology 2017 Jan 18. Epub 2017 Jan 18.
    Center for Bioscience Research and Education, Utsunomiya University, Tochigi, 321-8505, Japan.
    Hyperuricemia is recognized as an important risk factor for gout. High dietary intake of purine-rich foods such as meats and sea foods increases uric acid (UA) levels in the blood. Taxifolin present in Siberian larch and strawberries has been reported to possess health promoting activities including anti-oxidant effect. Read More

    The Prevalence of Nonalcoholic Fatty Liver Disease and Related Metabolic Comorbidities Was Associated with Age at Onset of Moderate to Severe Plaque Psoriasis: A Cross-Sectional Study.
    PLoS One 2017 18;12(1):e0169952. Epub 2017 Jan 18.
    Department of Dermatology, Shanghai Dermatology Hospital, Shanghai, China.
    Nonalcoholic fatty liver disease (NAFLD) has been found to be highly prevalent in psoriatic patients. Adult onset psoriasis could be divided into either early or late onset psoriasis. The associations between NAFLD and related metabolic comorbidities and age at onset of psoriasis have not yet been investigated. Read More

    Factors associated with initiation and persistence of urate-lowering therapy.
    Arthritis Res Ther 2017 Jan 17;19(1). Epub 2017 Jan 17.
    Department of Rheumatology, University of Gothenburg, Gothenburg, Sweden.
    Background: Gout is the most common inflammatory arthritic disease and is caused by crystal deposition secondary to persistent hyperuricemia. Etiological treatment with urate-lowering therapy (ULT) has been available since the 1950s but previous studies have demonstrated suboptimal degree of treatment. In recent years we have seen recommendations for ULT earlier in the course of the disease, but there are few contemporary reports reflecting the current situation. Read More

    Hyperuricemia increases the risk of acute kidney injury: a systematic review and meta-analysis.
    BMC Nephrol 2017 Jan 17;18(1):27. Epub 2017 Jan 17.
    Department of Nephrology, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai, 200032, People's Republic of China.
    Background: Mounting evidence indicated that the elevated serum uric acid level was associated with an increased risk of acute kidney injury (AKI). Our goal was to systematically evaluate the correlation of serum uric acid (SUA) level and incidence of AKI by longitudinal cohort studies.

    Methods: We searched electronic databases and the reference lists of relevant articles. Read More

    Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.
    BMC Med Genet 2017 Jan 17;18(1). Epub 2017 Jan 17.
    Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA.
    Background: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Read More

    Chronic kidney disease in Chinese postmenopausal women: A cross-sectional survey.
    Niger J Clin Pract 2017 Feb;20(2):153-157
    Division of Nephrology, Peking University Institute of Nephrology, University First Hospital, Beijing, P. R. China.
    Introduction: Despite advances in the management of chronic kidney disease (CKD), there is ongoing uncertainty regarding the prevalence of CKD in postmenopausal women. This study was designed to investigate both CKD prevalence and related risk factors in a cohort of postmenopausal Chinese women.

    Materials And Methods: A cross-sectional survey was administered to a nationally representative sample of female Chinese participants, including a total of 47,204 subjects, among whom were 8573 self-reported postmenopausal women. Read More

    The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica).
    J Ethnopharmacol 2017 Jan 12. Epub 2017 Jan 12.
    Laboratório de Plantas Medicinais (LAPLAMED), CiPharma, Escola de Farmácia, Campus da Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
    Ethnopharmacological Relevance: Lychnophora passerina (Mart ex DC) Gardn (Asteraceae), popularly known as Brazilian arnica, is used in Brazilian folk medicine to treat pain, rheumatism, bruises, inflammatory diseases and insect bites.

    Aim Of The Study: Investigate the influence of the seasons on the anti-inflammatory and anti-hyperuricemic activities of ethanolic extract of L. passerina and the ratio of the goyazensolide content, main chemical constituent of the ethanolic extract, with these activities. Read More

    Limitations of the Current Standards of Care for Treating Gout and Crystal Deposition in the Primary Care Setting: A Review.
    Clin Ther 2017 Jan 11. Epub 2017 Jan 11.
    Department of Medicine, Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, North Carolina. Electronic address:
    Purpose: This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for gout based on the most current guidelines, opportunities for improving gout management, and current and emerging therapies for gout.

    Methods: [PubMed and Google Scholar databases] were search for all articles and trials published before 2016, using the key terms [hyperuricemia, gout, tophi, joint erosion, joint damage, treatment guidelines, American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), flare, comorbidity, epidemiology, adherence, serum uric acid (sUA), monosodium urate (MSU), <6 mg/dL, MSU crystal formation, as well as individual drug names and classes of treatments of interest (allopurinol, febuxostat, colchicine, non-steroidal anti-inflammatories (NSAIDs)]. Read More

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