- Oksana V Muzychka,
- Oleksandr L Kobzar,
- Antonina V Popova,
- Mykhaylo S Frasinyuk,
- Andriy I Vovk
Bioorg Med Chem 2017 May 6. Epub 2017 May 6.
Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Murmanska, 1, 02660, Kyiv 94, Ukraine. Electronic address:
Xanthine oxidase is a potential target for treatment of hyperuricemia and gout. In this study, a number of A- and B-ring carboxylated aurone derivatives were synthesized and evaluated for their ability to inhibit xanthine oxidase in vitro. According to the results obtained, two different ranges of inhibitory activity were observed. Read More