2,720 results match your criteria Hypertrophic Osteoarthropathy

A Case of Progressive Thickening and Furrowing of Facial Skin and Scalp with Scarring Alopecia.

Skin Appendage Disord 2021 Apr 11;7(3):237-242. Epub 2021 Mar 11.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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Multiple small intestinal ulcers with SLCO2A1 and PLA2G4A mutation in a Chinese patient.

Dig Liver Dis 2021 May 26. Epub 2021 May 26.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China. Electronic address:

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J Clin Res Pediatr Endocrinol 2021 May 24. Epub 2021 May 24.

Karadeniz Technical University Faculty of Medicine, Medical Geneticist, Specialist, Erzurum, Turkey.

Pachydermoperiostosis (PDP), also known as primary hypertrophic osteoarthropathy is a rare genetic disorder characterized bypachyderma and periostosis.Acromegaly is a condition caused by excessive secretion of growth hormone leading to elevated insulin growth factor-1 levels, which is characterised by somatic overgrowth and physical disfigurement notably affecting hands and feet. We presented two cases referred with an initial diagnosis of acromegaly and were ultimately diagnosed as PDP. Read More

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Doege-Potter Syndrome with a Benign Solitary Fibrous Tumor: A Case Report and Literature Review.

Case Rep Oncol 2021 Jan-Apr;14(1):470-476. Epub 2021 Mar 18.

Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA.

Doege-Potter syndrome is a rare paraneoplastic syndrome that is often diagnosed incidentally during the workup of hypoglycemia of unclear etiology. It is characterized by a non-islet cell tumor hypoglycemia secondary to excessive production of partially processed IGF-II hormone from a solitary fibrous tumor (SFT). Often these tumors are intrathoracic, benign, and asymptomatic. Read More

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"Black nails" as a sign of hypertrophic osteoarthropathy.

Rheumatology (Oxford) 2021 Apr 24. Epub 2021 Apr 24.

Department of Rheumatology, Hospital del Mar, Barcelona, Spain.

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Monoallelic mutations in SLCO2A1 cause autosomal dominant primary hypertrophic osteoarthropathy.

J Bone Miner Res 2021 Apr 14. Epub 2021 Apr 14.

Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Primary hypertrophic osteoarthropathy (PHO) is a rare disease inherited as a recessive or irregular dominant trait and characterized by digital clubbing, pachydermia, and periostosis. Biallelic mutations in HPGD and SLCO2A1, disturbing prostaglandin E (PGE ) catabolism and leading to increased circulating PGE level, cause PHO autosomal recessive 1 (PHOAR1) and PHO autosomal recessive 2 (PHOAR2), respectively. However, no causative genes have been reported for PHO autosomal dominant (PHOAD). Read More

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Cutaneous Paraneoplastic Syndromes with Nail Involvement.

Dermatol Clin 2021 Apr 12;39(2):175-182. Epub 2021 Feb 12.

Nail Disease Centre, Rue des Serbes 42, Cannes 06400, France.

The cutaneous paraneoplastic syndromes are rare and intrinsically devoid of any neoplastic nature. The manifestations on the skin and the nails are due to various mechanisms caused by the tumor, either due to production of bioactive substances or in response to it. These disorders evolve in parallel to the malignancy, in that, they regress when the tumor is removed and reappear in the case of tumor recurrence. Read More

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[A Case of Lung Adenocarcinoma with Pulmonary Hypertrophic Osteoarthropathy].

Gan To Kagaku Ryoho 2021 Feb;48(2):297-299

Dept. of Surgery, Kishiwada Tokushukai Hospital.

Background: Hypertrophic osteoarthropathy(HOA)is a syndrome that has three signs, the digital finger, periosteal neoplasia of the iliac bone, and arthritis. Among them, the secondary 1 associated with lung disease is called pulmonary hypertrophic osteoarthropathy(PHO). It is reported that many of the underlying diseases are associated with primary lung cancer, but in Japan, this is a rare condition with about 0. Read More

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February 2021

gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy.

J Orthop Translat 2021 May 28;28:10-11. Epub 2021 Jan 28.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan.

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Establishment of a novel human iPSC line (SDQLCHi032-A) derived from a patient with primary hypertrophic osteoarthropathy caused by HPGD homozygous mutation.

Stem Cell Res 2021 Apr 1;52:102217. Epub 2021 Feb 1.

Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China. Electronic address:

Primary hypertrophic osteoarthropathy, autosomal recessive type 1 (PHOAR1, MIM259100) is caused by mutations in the 15-hydroxyprostaglandin dehydrogenase gene (HPGD, MIM601688) on chromosome 4q34. An induced pluripotent stem cells (iPSCs) line was generated in our lab from peripheral blood mononuclear cells (PBMCs) of a 2-year-7-month-old girl with PHOAR1 carrying a homozygous mutation of c.310_311del in HPGD. Read More

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Hypertrophic Osteoarthropathy: A Secondary Manifestation of Malignant Melanoma.

Case Rep Rheumatol 2021 18;2021:6691320. Epub 2021 Jan 18.

HonorHealth Internal Medicine Residency, Scottsdale, AZ, USA.

Background: Hypertrophic osteoarthropathy (HOA) is a rare finding in the setting of metastatic melanoma. A majority of cases of secondary HOA involve lung malignancies. Evaluation of presenting symptoms such as polyarthralgia and clubbing followed by review of imaging studies are diagnostic steps for HOA. Read More

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January 2021

Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action.

Pharmacol Ther 2021 Jul 16;223:107803. Epub 2021 Jan 16.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan.

Solute carrier organic anion transporter family member 2A1 (SLCO2A1, also known as PGT, OATP2A1, PHOAR2, or SLC21A2) is a plasma membrane transporter consisting of 12 transmembrane domains. It is ubiquitously expressed in tissues, and mediates the membrane transport of prostaglandins (PGs, mainly PGE, PGF, PGD) and thromboxanes (e.g. Read More

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A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing.

Chest 2021 01;159(1):e45-e48

Department of Pediatric Pulmonology, Ankara University School of Medicine, Ankara, Turkey.

Case Presentation: A 2-year-old boy was referred to the Ankara University School of Medicine Children's Hospital with a history of recurrent respiratory distress and cyanosis since birth. His medical history was significant for premature birth at 31 weeks via cesarean section, as an infant of a diabetic mother. There was no parental consanguinity. Read More

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January 2021

[Clinical and genetic characteristics of patients with chronic enteropathy associated with SLCO2A1 gene].

Zhonghua Nei Ke Za Zhi 2021 Jan;60(1):45-50

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To determine the clinical features and genetic characters of patients with chronic enteropathy associated SLCO2A1 gene (CEAS). Five CEAS patients diagnosed at Peking Union Medical College Hospital from January 2012 to December 2019 were enrolled in this study. The clinical manifestations, laboratory test, radiological and endoscopic findings, gene detections, treatments and prognosis of these patients were reviewed and analyzed. Read More

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January 2021

Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review.

Clin Case Rep 2020 Dec 3;8(12):3510-3514. Epub 2020 Nov 3.

Department of Infectious, Respiratory, and Digestive Medicine Graduate School of Medicine University of the Ryukyus Nishihara Japan.

Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare paraneoplastic syndrome. Our literature review shows the location of arthralgia and existence of edema are referable information for the differential diagnosis in paraneoplastic arthralgia. Read More

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December 2020

Characterization of Mineral and Bone Metabolism Biomarkers in a Chinese Consanguineous Twin Family with Primary Hypertrophic Osteoarthropathy.

Int J Endocrinol 2020 3;2020:6698878. Epub 2020 Dec 3.

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, China.

Purpose: Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In this study, we describe the clinical characteristics, SLCO2A1 mutations, and bone metabolic markers of a PHO pedigree from a Chinese consanguineous twin family. Read More

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December 2020

Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis.

Intern Med 2020 15;59(24):3147-3154. Epub 2020 Dec 15.

Department of General Internal Medicine, Saitama Medical University, Japan.

A 49-year-old man complained of chronic palpitation and shortness of breath, which had recently become exacerbated. A blood examination indicated severe refractory anemia and hypoproteinemia. Physical examinations revealed anemia, a systolic murmur, and spoon nails. Read More

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Primary hypertrophic osteoarthropathy with severe arthralgia identified by gene mutation of .

Mod Rheumatol Case Rep 2021 Jan 18:1-7. Epub 2021 Jan 18.

Department of Maternal-Fetal Biology, National Center for Child Health and Development, Tokyo, Japan.

Male, 41 years old (yo) had been complaining of severe arthralgia. Past History indicated obstruction of intestinal tract at 12 yo and gastric ulcer at 13 yo. He had been suffered from polyarthralgia especially at PIP and MP joints of both hands from 38 yo. Read More

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January 2021

Atypical and incomplete pulmonary hypertrophic osteoarthropathy in the left distal femur: a case report.

BMC Surg 2020 Nov 23;20(1):293. Epub 2020 Nov 23.

Department of Orthopaedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Pulmonary hypertrophic osteoarthropathy (PHO) is a rare paraneoplastic syndrome that mainly occurs in patients with lung cancer. Most symptoms occur symmetrically, and unilateral symptoms without clubbing are infrequent. This report presents the case of a rare atypical symptom that was highly suspected of being PHO. Read More

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November 2020

Primary pulmonary lymphoepithelioma-like carcinoma accompanied by hypertrophic pulmonary osteoarthropathy in a non-epidemic region: a case report and literature review.

J Int Med Res 2020 Nov;48(11):300060520965816

Department of Respiratory and Critical Care Medicine, Ningbo First Hospital, Ningbo, China.

Pulmonary lymphatic epithelioma-like carcinoma (LELC) is a rare and unique subtype, accounting for 0.9% of all lung cancers. To date, just over 200 cases have been reported worldwide. Read More

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November 2020

Ankle arthritis - an important signpost in rheumatologic practice.

Rheumatology (Oxford) 2021 01;60(1):23-33

Department of Rheumatology, Frimley Health NHS Foundation Trust, Frimley, UK.

Ankle arthritis is a useful clinical signpost to differential diagnosis in rheumatic disease. Biomechanical features and differences in cartilage physiology compared with the knee may confer protection of the ankle joint from factors predisposing to certain arthritides. The prevalence of ankle OA is low, and usually secondary to trauma. Read More

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January 2021

Bone Scintigraphy in Pembrolizumab-Induced Inflammatory Arthritis.

Clin Nucl Med 2020 Dec;45(12):999-1000

From the Department of Radiology, Toranomon Hospital, Tokyo, Japan.

We present a novel report on the use of bone scintigraphy in pembrolizumab-induced inflammatory arthritis. A 70-year-old man with lung cancer complained about arthralgia after 7 courses of the pembrolizumab therapy. Tc-HMDP bone scintigraphy revealed symmetrically strong uptakes in the major distal joints of the upper and lower extremities, thereby clearly identifying them as the affected joints. Read More

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December 2020

Oldest evidence of tuberculosis in Argentina: A multidisciplinary investigation in an adult male skeleton from Saujil, Tinogasta, Catamarca (905-1030 CE).

Tuberculosis (Edinb) 2020 12 22;125:101995. Epub 2020 Sep 22.

University of Buenos Aires, Institute of Cultures (IDECU, UBA-CONICET), Faculty of Philosophy and Letters, Buenos Aires, Argentina. Electronic address:

The Mycobacterium tuberculosis complex (MTC) has affected South American populations since ca. 200 years BCE. In Argentina, possible cases date from ca. Read More

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December 2020

Pulmonary Sarcomatoid Giant Cell Carcinoma with Paraneoplastic Hypertrophic Osteoarthropathy: A Case Report.

Am J Med Case Rep 2020 12;8(7):162-165. Epub 2020 Apr 12.

Department of Internal Medicine, SUNY- Downstate Health Science University, 450 Clarkson Avenue, Box 50, Brooklyn, NY 11203.

Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 57 year old female with a past medical history of HIV on HAART (CD4 count at the time was 621 cell/μl). She presented to the hospital with a two months history of productive cough with yellowish sputum containing streaks of blood, twelve pound weight loss, bilateral hand swelling, and knee pain with noticeable finger clubbing on physical examination. Read More

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Hypertrophic pulmonary osteoarthropathy with esophageal sarcomatoid carcinoma: a case report.

Ann Palliat Med 2021 May 16;10(5):5862-5869. Epub 2020 Sep 16.

Department of Radiation Oncology, Department of VIP Medical Services, National Carcinoma Center/National Clinical Research Center for Carcinoma/Carcinoma Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Hypertrophic pulmonary osteoarthropathy (HPOA), mainly manifested clubbing, is rare in patients with esophageal sarcomatoid carcinoma. We herein describe a 48-year-old Chinese man whose advanced sarcomatoid carcinoma was diagnosed while examining his symptoms of HPOA. The patient had no opportunity of surgery after surgical evaluation. Read More

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Rosai-Dorfman Disease Occurring in Elderly Patient With Long-Standing Idiopathic Hypertrophic Osteoarthropathy.

J Clin Rheumatol 2020 Sep 4. Epub 2020 Sep 4.

From the Department of Medicine, NYC Health + Hospitals/Woodhull, Brooklyn, NY.

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September 2020

Sudden onset polyarthritis as a paraneoplastic syndrome from non-small cell lung cancer.

J Community Hosp Intern Med Perspect 2020 May 21;10(2):174-178. Epub 2020 May 21.

Methodist Dallas Medical Center, Dallas, TX, USA.

A 48-year-old male presented to the emergency room for 2 weeks of joint pain and swelling of his four extremities. His symptoms started suddenly and were quite debilitating. His hands, fingers, knees, and ankles were so swollen and painful that he was unable to get out of bed and had to use crutches to ambulate. Read More

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[Primary hypertrophic osteoarthropathy with renal hypokalemia: a case report].

Zhonghua Nei Ke Za Zhi 2020 Sep;59(9):720-723

Department of Endocrinology, Fuyang People's Hospital of Anhui Province, Fuyang, Anhui 236003, China.

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September 2020

Hypertrophic Pulmonary Osteoarthropathy Revealing a Solitary Fibrous Tumor.

Mayo Clin Proc 2020 08;95(8):1567-1568

Department of Clinical Immunology & Infectious Diseases, Centre Hospitalier de Vienne Lucien Hussel, Médecine interne, Montée du Dr Chapuis, Vienne, Rhône-Alpes, France. Electronic address:

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