2,614 results match your criteria Hypertrophic Osteoarthropathy


Review of paraneoplastic syndromes in children.

Pediatr Radiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02215, USA.

Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. Read More

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http://dx.doi.org/10.1007/s00247-019-04371-yDOI Listing
March 2019
3 Reads

Complete primary pachydermoperiostosis: A case report from Jordan and review of literature.

Clin Case Rep 2019 Feb 9;7(2):346-352. Epub 2019 Jan 9.

Special Surgery Department Jordan University Hospital Amman Jordan.

Complete Primary Pachydermoperiostosis is a rare syndrome that presents with skin and skeletal manifestations. Though diagnosis can be made on the basis of the classic clinical and radiological features, it is often missed due to variable presentations. Therefore, it is important to know about this syndrome to reach correct diagnosis. Read More

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http://dx.doi.org/10.1002/ccr3.1971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389490PMC
February 2019

Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report.

J Med Case Rep 2019 Feb 21;13(1):39. Epub 2019 Feb 21.

Tribhuvan University Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Background: Pachydermoperiostosis (PDP) is a rare disorder characterized by clubbing of the fingers, thickening of the skin (pachyderma), and excessive sweating (hyperhidrosis). It typically appears during childhood or adolescence, often around the time of puberty, and progresses slowly. Clinical presentations of PDP can be confused with secondary hypertrophic osteoarthropathy, psoriatic arthritis, rheumatoid arthritis, thyroid acropachy, and acromegaly. Read More

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http://dx.doi.org/10.1186/s13256-018-1961-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383214PMC
February 2019
1 Read

Successful Treatment of ROS1-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy: A Case Report.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan.

Hypertrophic pulmonary osteoarthropathy (HPO) is a paraneoplastic syndrome characterized by digital clubbing, arthritis, and periostitis. Tumor removal usually leads to the resolution of these symptoms. We herein report the efficacy of crizotinib treatment for treating the symptoms of HPO associated with c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1982-18DOI Listing
January 2019
2 Reads

Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis.

AJR Am J Roentgenol 2019 Jan 7;212(1):157-165. Epub 2018 Nov 7.

1 Department of Radiology, University of Illinois College of Medicine, 1740 W Taylor St, Rm. 2483 (MC 931), Chicago, IL 60612.

Objective: Voriconazole is an antifungal medication used primarily for the treatment of Candida and Aspergillus infections. A fairly newly described side effect of long-term voriconazole use is periostitis. The purpose of this article is to describe the main differential consideration-hypertrophic osteoarthropathy-and other differential diagnoses, including venous stasis, thyroid acropachy, and hypervitaminosis A. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.19991
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http://dx.doi.org/10.2214/AJR.18.19991DOI Listing
January 2019
19 Reads

A male Korean who was diagnosed with chronic enteropathy associated with (CEAS): case report with literature review.

BMJ Open Gastroenterol 2018 23;5(1):e000223. Epub 2018 Oct 23.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Objective: To further disseminate the nomenclature of chronic enteropathy associated with SLCO2A1 (CEAS), especially for physicians in China and Korea where the genetic feature of gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied. gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied.

Design: A case report with literature review of gene mutations-related disorders. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202987PMC
October 2018
9 Reads

Novel SLCO2A1 mutations cause gender differentiated pachydermoperiostosis.

Endocr Connect 2018 Aug 1. Epub 2018 Aug 1.

Y Wu, Department of Biochemistry and Molecular Biology, Center for DNA Typing, Fourth Military Medical University, Xi'an, China.

Primary hypertrophic osteoarthropathy (PHO) is a rare familial disorder with reduced penetrance for females. The genetic mutations associated with PHO have been identified in HPGD and SLCO2A1 which involved in prostaglandin E2 metabolism. Here we report 5 PHO patients from 4 non-consanguineous families. Read More

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https://ec.bioscientifica.com/downloadpdf/journals/ec/aop/ec
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https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-032
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http://dx.doi.org/10.1530/EC-18-0326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223238PMC
August 2018
4 Reads

Co-morbidity with hypertrophic osteoarthropathy: A possible Iron Age Sarmatian case from the Volga steppe of Russia.

Int J Paleopathol 2019 Mar 5;24:66-78. Epub 2018 Oct 5.

Department of Electronic Devices, St. Petersburg State Electrotechnical University «LETI», 5 Professora Popova street, St. Petersburg, Russia. Electronic address:

Purpose: Hypertrophic osteoarthropathy (HOA) is a condition that can be inherited or acquired. It causes diffuse periosteal new bone formation on the long bones, with a predilection for the appendicular skeleton. When acquired, it is a nonspecific indicator of systemic disease that arises following a primary condition. Read More

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http://dx.doi.org/10.1016/j.ijpp.2018.09.007DOI Listing
March 2019
6 Reads

Targeted exome sequencing identified a novel mutation hotspot and a deletion in Chinese primary hypertrophic osteoarthropathy patients.

Clin Chim Acta 2018 Dec 4;487:264-269. Epub 2018 Oct 4.

Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children's Medical Center, Shanghai Jiao tong University School of Medicine, Shanghai 200127, PR China; Institute of Pediatric Translational Medicine, Shanghai Jiao tong University School of Medicine, Shanghai 200127, PR China. Electronic address:

Background: Primary hypertrophic osteoarthropathy (PHO) is a genetically and clinically heterogeneous systematic disorder caused by mutations in genes HPGD and SLCO2A1. The purpose of the present study is to provide useful information for the early and precise diagnosis of PHO and identify causative mutations in Chinese PHO children.

Methods And Results: The clinical manifestations, radiographic features of seven Chinese pediatric patients were systematically analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981183053
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http://dx.doi.org/10.1016/j.cca.2018.10.005DOI Listing
December 2018
3 Reads
2.820 Impact Factor

GUT AND BONE CONNECTION: CELIAC DISEASE PRESENTED AS HYPERTROPHIC OSTEOARTHROPATHY.

Endocr Pract 2018 Oct 5. Epub 2018 Oct 5.

From: Division of Diabetes and Endocrinology, Department of Medicine, University of Minnesota.

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http://dx.doi.org/10.4158/EP-2018-0370DOI Listing
October 2018
3 Reads

Pulmonary arteriovenous malformations.

QJM 2019 Feb;112(2):141-142

Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/qjmed/hcy207DOI Listing
February 2019
13 Reads

Hypertrophic osteoarthropathy: Detecting periosteal inflammation using Doppler ultrasound.

Eur J Rheumatol 2018 Jul 25;5(2):151-152. Epub 2017 Oct 25.

Department of Rheumatology, NTT Sapporo Medical Center, Sapporo, Japan.

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http://dx.doi.org/10.5152/eurjrheum.2017.17060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072694PMC
July 2018
3 Reads

[Two cases of primary hypertrophic osteoarthropathy with SLCO2A1 gene mutations].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):100-105

Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Two patients with primary hypertrophic osteoarthropathy (PHO) and their available healthy family members were studied. All exons of the SLCO2A1 and HPGD gene and adjacent exon-intron sequences were amplified by PCR and subsequently sequenced. To assess the damaging effects of missense mutations in silico, the online database, PolyPhen-2 and SIFT were used. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.01.016DOI Listing
January 2018
8 Reads

Clubbing and pachydermoperiostosis.

Authors:
M-H Lin C-H Hsieh

QJM 2018 Nov;111(11):833-834

Division of Endocrinology and Metabolism, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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https://academic.oup.com/qjmed/article/111/11/833/5040729
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http://dx.doi.org/10.1093/qjmed/hcy132DOI Listing
November 2018
9 Reads

A Case of Hypertrophic Pulmonary Osteoarthropathy in Both Upper and Lower Extremities: A Rare Involvement.

Mol Imaging Radionucl Ther 2018 Jun;27(2):88-90

Ankara Numune Training and Research Hospital, Clinic of Nuclear Medicine, Ankara, Turkey.

Hypertrophic pulmonary osteoarthropathy (HPOA) is a paraneoplastic manifestation of gastric and, more frequently, lung carcinomas. It is characterized by extremity pain, clubbing, arthritis and periostitis of the long bones. Periostitis is the hallmark of HPOA and can be revealed with bone scintigraphy. Read More

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http://dx.doi.org/10.4274/mirt.78941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996602PMC
June 2018
17 Reads

Lung cancer, clubbing and hypertrophic pulmonary osteoarthropathy.

QJM 2018 Nov;111(11):825

Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

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http://dx.doi.org/10.1093/qjmed/hcy119DOI Listing
November 2018
12 Reads

Pachydermoperiostosis Mimicking Acromegaly: A Case Report.

Indian Dermatol Online J 2018 May-Jun;9(3):182-184

Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Pachydermoperiostosis is a rare, hereditary disease commonly presenting with digital clubbing, pachyderma, and periosteal hypertrophy. Coarsening of facial features and spade-like enlargement of hands and feet may give rise to a diagnostic dilemma between pachydermoperiostosis and acromegaly. This report highlights a case of a 36-year-old man who presented with broadening of hands and feet, facial skin thickening, and edematous and drooping eyelids for the last 10 years. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_230_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956866PMC
June 2018
18 Reads

Comprehensive Surgical Strategies for the Management of Pachydermoperiostosis.

Facial Plast Surg 2018 Jun 15;34(3):330-334. Epub 2018 May 15.

Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The cosmetic and functional deformities induced by thickened folds and furrows are the main complaints of patients in pachydermoperiostosis (PDP). However, traditional drug therapy only has a limited effect for its unclear genetic pathogenesis. Surgical treatment has now become one of the optimal strategies mainly aiming for its cosmetic improvement. Read More

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http://dx.doi.org/10.1055/s-0038-1653992DOI Listing
June 2018
3 Reads

Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.

BMC Musculoskelet Disord 2018 May 14;19(1):145. Epub 2018 May 14.

Department of Medical Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 449, 34149, Trieste, Italy.

Background: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-018-2068-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952696PMC
May 2018
19 Reads

FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2.

Endocrinology 2018 06;159(6):2386-2396

Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, UConn Health, Farmington, Connecticut.

Although humans with X-linked hypophosphatemia (XLH) and the Hyp mouse, a murine homolog of XLH, are known to develop degenerative joint disease, the exact mechanism that drives the osteoarthritis (OA) phenotype remains unclear. Mice that overexpress high-molecular-weight fibroblast growth factor (FGF) 2 isoforms (HMWTg mice) phenocopy both XLH and Hyp, including OA with increased FGF23 production in bone and serum. Because HMWTg cartilage also has increased FGF23 and there is cross-talk between FGF23-Wnt/β-catenin signaling, the purpose of this study was to determine if OA observed in HMWTg mice is due to FGF23-mediated canonical Wnt signaling in chondrocytes, given that both pathways are implicated in OA pathogenesis. Read More

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https://academic.oup.com/endo/article/159/6/2386/4985542
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http://dx.doi.org/10.1210/en.2018-00184DOI Listing
June 2018
13 Reads

Hepatobiliary and Pancreatic: Rare hepatic vascular tumor presenting with hypertrophic osteoarthropathy.

Authors:
H Caterson K Liu

J Gastroenterol Hepatol 2018 Aug 24;33(8):1434. Epub 2018 Apr 24.

AW Morrow Gastroenterology and Liver Center, Royal Prince Alfred Hospital, Sydney, Australia.

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http://dx.doi.org/10.1111/jgh.14087DOI Listing
August 2018
7 Reads

A novel homozygous mutation in the SLCO2A1 gene causing pachydermoperiostosis: Efficacy of hydroxychloroquine treatment.

Am J Med Genet A 2018 05;176(5):1253-1257

Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.

Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation. Joint pain, polyarthritis, cutis verticis gyrata, seborrhea, and hyperhidrosis are frequently associated to this condition. We report a 17-year-old boy presented with pain and swelling of knees and ankles, and progressive thickening of skin face with seborrhea from about 4 years. Read More

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http://dx.doi.org/10.1002/ajmg.a.38677DOI Listing
May 2018
21 Reads

[Identification of a HPGD mutation in three families affected with primary hypertrophic osteoarthropathy].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Apr;35(2):156-159

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.

Objective: To detect mutation of HPGD gene among three pedigrees affected with primary hypertrophic osteoarthropathy (PHO) by DNA sequencing and high-resolution melting (HRM) analysis.

Methods: Genomic DNA was extracted from peripheral blood samples collected from the pedigrees. PCR and direct sequencing were carried out to identify potential mutations of the HPGD gene. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.02.002DOI Listing
April 2018
8 Reads

Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma.

J Clin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.

University of Washington School of Medicine Seattle, WA Division of Pediatric Radiology Department of Radiology University of Washington School of Medicine and Seattle Children's Hospital Seattle, WA. Division of Rheumatology Department of Pediatrics University of Washington School of Medicine and Seattle Children's Hospital Seattle, WA

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http://Insights.ovid.com/crossref?an=00124743-900000000-9928
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http://dx.doi.org/10.1097/RHU.0000000000000722DOI Listing
April 2018
21 Reads

Incomplete form of Primary Hypertrophic Osteoarthropathy (Touraine-Solente-Gole Syndrome) Masquerading as Polyartrhalgia Diagnosed in Technetium-99m-Methylene Diphosphonate Scintigraphy: An Interesting Case Report.

Indian J Nucl Med 2018 Apr-Jun;33(2):128-131

Department of Nuclear Medicine and PET-CT, Apollo Hospitals, Chennai, Tamil Nadu, India.

The primary hypertrophic osteoarthropathy (PHOA) (pachydermoperiostosis) is a rare genetic/hereditary disease characterized by skin changes (pachydermia), clubbing of fingers and periosteal thickening (periostitis) with sub-periosteal new bone formation. Here we describe a case of an adolescent male who presented with clubbing and polyarthralgia. On evaluation with scintigraphy and SPECT-CT, he was diagnosed to have incomplete form of PHOA(skeletal manifestations without skin changes). Read More

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http://www.ijnm.in/text.asp?2018/33/2/128/227493
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http://dx.doi.org/10.4103/ijnm.IJNM_134_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883430PMC
April 2018
19 Reads

[Paraneoplastic syndromes in rheumatology].

Authors:
Marc Schmalzing

Z Rheumatol 2018 May;77(4):309-321

Zentrum Innere Medizin, Medizinische Klinik und Poliklinik II, Rheumatologie/Klinische Immunologie, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.

Rheumatic paraneoplastic syndromes are paraneoplastic arthritis, palmar fasciitis and polyarthritis syndrome, remitting seronegative symmetrical synovitis with pitting edema, pancreatic panniculitis with polyarthritis, paraneoplastic vasculitis, cancer-associated myositis, hypertrophic osteoarthropathy (Marie-Bamberger disease) and tumor-induced osteomalacia. Typical clinical manifestations, pathogenesis, prognosis, and treatment of this entity are presented. Knowledge of these disease entities can lead to timely diagnosis of the underlying malignant disease and to a higher probability of a cure. Read More

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http://dx.doi.org/10.1007/s00393-018-0445-2DOI Listing
May 2018
8 Reads

Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy.

Am J Case Rep 2018 Mar 9;19:267-271. Epub 2018 Mar 9.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865406PMC
March 2018
20 Reads

Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.

J Med Case Rep 2018 Mar 8;12(1):59. Epub 2018 Mar 8.

Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Background: Primary hypertrophic osteoarthropathy also known as pachydermoperiostosis is a rare genetic disorder that has often been confused with acromegaly because of similar clinical features. Vascular endothelial growth factors which have been implicated in the clinical features of pachydermoperiostosis, have also been shown to be present in chronic hepatitis and implicated in the malignant transformation of hepatitis B infection to hepatocellular carcinoma. To the best of our knowledge there is one reported case of pachydermoperiostosis with chronic hepatitis B infection. Read More

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http://dx.doi.org/10.1186/s13256-018-1578-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842528PMC
March 2018
19 Reads

Hypertrophic osteoarthropathy.

Med Clin (Barc) 2018 Dec 28;151(12):509. Epub 2018 Feb 28.

Servicio de Radiodiagnóstico, Hospital Clínico Universitario de Valladolid, Valladolid, España.

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http://dx.doi.org/10.1016/j.medcli.2018.01.010DOI Listing
December 2018
12 Reads

A young female with cyanosis and clubbing.

Eur J Intern Med 2018 08 2;54:e7. Epub 2018 Mar 2.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183008
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http://dx.doi.org/10.1016/j.ejim.2018.02.023DOI Listing
August 2018
17 Reads

Hypertrophic Osteopathy Associated with Mycotic Pneumonia in a Roe Deer ( Capreolus capreolus).

J Wildl Dis 2018 07 2;54(3):631-634. Epub 2018 Mar 2.

1 Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.

Aspergillus fumigatus is one of the most common Aspergillus species causing disease in individual animals but it rarely affects deer species. We report a case of A. fumigatus infection causing mycotic pneumonia and hypertrophic osteopathy in a roe deer ( Capreolus capreolus). Read More

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http://dx.doi.org/10.7589/2017-07-171DOI Listing
July 2018
12 Reads

Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany.

Int J Paleopathol 2018 Mar 21;20:72-79. Epub 2017 Nov 21.

Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart, Stromeyersdorfstraße 3, 78467, Konstanz, Germany; Eberhard Karls University Tübingen, Institute for Archaeological Science, Rümelinstraße 23, 72070, Tübingen, Germany.

Hypertrophic osteoarthropathy (HOA) is rarely diagnosed in archaeological human skeletons. Here, we report on the well-preserved skeleton of a middle-adult man from the early Medieval settlement site of Lauchheim (Germany) that exhibits pronounced multi-layered shell-like periosteal new bone formation in a bilaterally symmetric fashion on the long bones, the skeletal elements of the pelvis and those of the pectoral girdle. In addition, the two distal phalanges recovered show signs of osteoclastic resorption on their distal tuberosities. Read More

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http://dx.doi.org/10.1016/j.ijpp.2017.10.013DOI Listing
March 2018
19 Reads

Hypertrophic osteoarthropathy: estrogens, prostaglandinE, prostaglandin A, and the inflammatory reflex.

Clin Rheumatol 2019 Jan 26;38(1):211-222. Epub 2018 Feb 26.

Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.

It has been claimed that hyperestrogenism occurs in hypertrophic osteoarthropathy (HOA), but not in simple clubbing. However, one of our patients had simple clubbing and hyperestrogenism. We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing. Read More

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http://dx.doi.org/10.1007/s10067-018-4044-zDOI Listing
January 2019
14 Reads

Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report.

J Med Case Rep 2018 Feb 16;12(1):38. Epub 2018 Feb 16.

Departamento de Endocrinología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.

Background: Exophthalmos, myxedema, and osteoarthropathy syndrome is a very rare condition that is associated with Graves' disease. The presence of dermopathy and the involvement of joint/bone tissues indicate that it seems to be related with the severity of the autoimmune process. Owing to its low incidence, there is a lack of information regarding its treatment and clinical follow-up. Read More

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http://dx.doi.org/10.1186/s13256-018-1571-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815205PMC
February 2018
14 Reads

Pachydermoperiostosis in a Patient with Crohn's Disease: Treatment and Literature Review.

Iran J Med Sci 2018 Jan;43(1):81-85

Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Pachydermoperiostosis (PDP) is a rare disorder characterized by pachydermia, digital clubbing, periostitis, and an excess of affected males. It is the primary form of hypertrophic osteoarthropathy (HOA) and there are some rare associations of PDP with other disorders. Here we describe a patient with Crohn's disease associated with PDP. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775998PMC
January 2018
22 Reads

Successful treatment of pachydermoperiostosis patients with etoricoxib, aescin, and arthroscopic synovectomy: Two case reports.

Medicine (Baltimore) 2017 Nov;96(47):e8865

Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.

Rationale: Pachydermoperiostosis (PDP) is a rare hereditary disorder that affects the skin and bones. PDP is characterized by periostosis, digital clubbing, and pachydermia. Previous studies demonstrated that increased prostaglandin E2 (PGE2) levels resulting from defective protein degradation pathways play a crucial role in PDP pathogenesis, and males were more commonly and severely affected than females. Read More

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http://dx.doi.org/10.1097/MD.0000000000008865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709004PMC
November 2017
22 Reads

Pierre-Marie-Bamberger syndrome and solitary fibrous tumor: a rare association.

Asian Cardiovasc Thorac Ann 2018 Feb 29;26(2):154-157. Epub 2018 Jan 29.

3 Pathology Department, 61679 Angeles del Pedregal Hospital , Mexico City, Mexico.

A solitary fibrous tumor originates in the pleura with variable degrees of invasion. Hypertrophic osteoarthropathy, known as Pierre-Marie-Bamberger syndrome, is characterized by clubbing of the fingers due to bone surface and soft tissue calcification, historically known as a bronchogenic carcinoma paraneoplastic syndrome; however, a few cases have been associated with solitary fibrous tumors. We describe the case of a 38-year-old woman who presented with clubbing of the fingers. Read More

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http://dx.doi.org/10.1177/0218492318757042DOI Listing
February 2018
18 Reads

Hypertrophic osteoarthropathy in a patient with known lung cancer.

Postgrad Med J 2018 May 20;94(1111):308-309. Epub 2018 Jan 20.

Department of Radiology, Dorset County Hospital NHS Foundation Trust, Dorchester, UK.

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http://dx.doi.org/10.1136/postgradmedj-2017-135365DOI Listing
May 2018
7 Reads

Proliferative Periostitis – eine seltene Differenzialdiagnose.

Rofo 2018 May 18;190(5):450-453. Epub 2018 Jan 18.

Diagnostic Radiology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

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http://dx.doi.org/10.1055/s-0043-125220DOI Listing
May 2018
18 Reads

[Paraneoplastic syndromes in rheumatology].

Internist (Berl) 2018 Feb;59(2):145-150

Rheumaeinheit, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Pettenkoferstr. 8a, 80336, München, Deutschland.

Malignancies can present as inflammatory rheumatic diseases. These rheumatic paraneoplastic syndromes are rare, but characteristic in their pattern. This article focuses on epidemiology, clinical and diagnostic features as well as treatment of paraneoplasic rheumatic diseases such as paraneoplastic arthritides, vasculitides, myositis and hypertrophic osteoarthropathy. Read More

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http://dx.doi.org/10.1007/s00108-017-0376-zDOI Listing
February 2018
9 Reads

Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease.

J Gastroenterol 2018 Aug 8;53(8):907-915. Epub 2018 Jan 8.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. Read More

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http://dx.doi.org/10.1007/s00535-017-1426-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061663PMC
August 2018
31 Reads

Effectiveness of non-steroidal anti-inflammatory drugs among patients with primary hypertrophic osteoarthropathy: A systematic review.

J Dermatol Sci 2018 Apr 28;90(1):21-26. Epub 2017 Dec 28.

Division of Dermatology, National Center for Child Health and Development, Tokyo, Japan.

Background: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811173101
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http://dx.doi.org/10.1016/j.jdermsci.2017.12.012DOI Listing
April 2018
23 Reads

[A boy with digital clubbing].

Ned Tijdschr Geneeskd 2017;161:D1807

Maastricht Universitair Medisch Centrum+, afd. Kindergeneeskunde, Maastricht.

A 4-year-old boy was referred because of pan-digital clubbing and watch-glass nails. Other remarkable findings were: surgical closure of a patent arterial duct, decreased knee-mobility and consanguineous parents. This combination is suggestive for primary hypertrophic osteoarthropathy (PHO; #OMIM 259100). Read More

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December 2018
19 Reads

Digital clubbing: A patient with hypertrophic osteoarthropathy and the presence of acro-osteolysis.

Reumatol Clin 2017 Dec 29. Epub 2017 Dec 29.

Unidad de Cuidados Críticos Urgente, San Fernando-Cádiz, San Fernando, Cádiz, España.

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http://dx.doi.org/10.1016/j.reuma.2017.11.012DOI Listing
December 2017
19 Reads

A novel mutation in the HPGD gene causing primary hypertrophic osteoarthropathy with digital clubbing in a Pakistani family.

Ann Hum Genet 2018 May 28;82(3):171-176. Epub 2017 Dec 28.

Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan.

Primary hypertrophic osteoarthropathy (PHO) is a congenital multisystemic entity characterized by three major clinical symptoms: pachydermia, periostosis, and digital clubbing. Recently it has been reported that pathogenic mutations in two genes are known to be associated with PHO: HPGD and SLCO2A1. In the present study, a five-generation consanguineous Pakistani family harboring primary hypertrophic osteoarthropathy in autosomal-recessive pattern was ascertained. Read More

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http://doi.wiley.com/10.1111/ahg.12239
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http://dx.doi.org/10.1111/ahg.12239DOI Listing
May 2018
32 Reads
2.210 Impact Factor

Pachydermoperiostosis Masquerading as Acromegaly.

J Endocr Soc 2017 Feb 16;1(2):109-112. Epub 2017 Jan 16.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OXE 7LE, United Kingdom.

Context: Acromegaly usually is suspected on clinical grounds. Biochemical confirmation is required to optimize therapy, but there are other differential diagnoses.

Case Description: We describe a 24-year-old Uzbek man who presented with many clinical symptoms and signs of apparent acromegaly. Read More

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http://dx.doi.org/10.1210/js.2016-1084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686560PMC
February 2017
8 Reads

Primary Hypertrophic Osteoarthropathy With SLCO2A1 Mutation in a Chinese Patient Successfully Treated With Etoricoxib.

J Clin Rheumatol 2018 Apr;24(3):164-167

Department of Rheumatology South Campus Ren Ji Hospital School of Medicine Shanghai Jiaotong University, Shanghai China

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http://Insights.ovid.com/crossref?an=00124743-900000000-9940
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http://dx.doi.org/10.1097/RHU.0000000000000647DOI Listing
April 2018
10 Reads