2,677 results match your criteria Hypertrophic Osteoarthropathy


Hypertrophic Osteoarthropathy Presenting as Rheumatoid Arthritis Mimicker: A Case Report.

Cureus 2020 Jul 19;12(7):e9271. Epub 2020 Jul 19.

Rheumatology, Pamukkale University, Denizli, TUR.

Paraneoplastic rheumatologic syndromes are defined as clinical conditions that mimic primary rheumatic disease in the course of cancer; they generally improve with the effective treatment of underlying malignancy. Hypertrophic osteoarthropathy (HOA) is one of the paraneoplastic syndromes, and it is characterized by the combined presence of periostosis, digital clubbing, and swelling of soft tissues, skin, and joints in the distal extremities. HOA is commonly associated with intrathoracic malignancies (primary lung tumors or metastases). Read More

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http://dx.doi.org/10.7759/cureus.9271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372233PMC

Secondary Hypertrophic Osteoarthropathy in Pediatric Hodgkin Lymphoma.

Arthritis Rheumatol 2020 Jul 20. Epub 2020 Jul 20.

Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada.

A 14-year-old previously healthy Caucasian boy presented to the Pediatric Rheumatology clinic with 6 months history of progressive distal extremity swelling, weakness, functional limitation, and 12kg weight loss. There were no fevers or night sweats. The remainder of the review of systems was unremarkable. Read More

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http://dx.doi.org/10.1002/art.41445DOI Listing

Pachydermoperiostosis: Classic Presentation of a Rare Disease.

Mediterr J Rheumatol 2020 Jun 30;31(2):214-215. Epub 2020 Jun 30.

Department of Clinical Immunology & Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

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http://dx.doi.org/10.31138/mjr.31.2.214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362114PMC

Recurrent hypertrophic pulmonary osteoarthropathy in an adult with bronchiectasis.

Respirol Case Rep 2020 Aug 23;8(6):e00602. Epub 2020 Jun 23.

Department of Respiratory Medicine Middlemore Hospital, Counties Manukau DHB Auckland New Zealand.

Hypertrophic pulmonary osteoarthropathy (HPOA) is a well-documented complication of pulmonary malignancy and cystic fibrosis (CF). However, HPOA associated with exacerbations of non-CF bronchiectasis has only been reported once previously in an adolescent. We describe a case of an adult patient with bronchiectasis and HPOA, whose joint symptoms flared during pulmonary exacerbations and improved with treatment of each exacerbation. Read More

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http://dx.doi.org/10.1002/rcr2.602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308669PMC

Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review.

Cureus 2020 May 1;12(5):e7919. Epub 2020 May 1.

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Solitary fibrous tumors (SFT) represent a unique subset of mostly benign heterogeneous tumors with mesenchymal cell origins. These tumors have been reported in the past as being mostly indolent, with a slowly evolving clinical course and low potential for malignancy. Although found systemically, the incidence of SFT arising intrathoracically, from the pleura of the lung, is relatively poorly documented in the medical literature. Read More

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http://dx.doi.org/10.7759/cureus.7919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263730PMC

Incomplete primary hypertrophic osteoarthropathy.

BMJ Case Rep 2020 May 13;13(5). Epub 2020 May 13.

Department of Orthopaedics, University College of Medical Sciences, New Delhi, Delhi, India.

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http://dx.doi.org/10.1136/bcr-2020-236034DOI Listing

More Than Knee Pain: A Case of Hypertrophic Osteoarthropathy Secondary to Lung Cancer.

J Emerg Med 2020 May 10. Epub 2020 May 10.

Saint Louis University School of Medicine, St Louis, Missouri; Division of Emergency Medicine, Saint Louis University Hospital, St Louis, Missouri.

Background: Hypertrophic osteoarthropathy (HOA) is a musculoskeletal pathology that often occurs as a paraneoplastic syndrome. 90% of HOA cases occur secondary to malignancy. 60 to 80% of which are lung cancers. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.028DOI Listing

Hypertrophic osteoarthropathy.

Best Pract Res Clin Rheumatol 2020 Apr 11:101507. Epub 2020 Apr 11.

Chief Rheumatology Department. National Institute of Cardiology, Juan Badiano 1, 14080, Mexico City, Mexico. Electronic address:

Hypertrophic osteoarthropathy (HOA) is an orphan syndrome characterized by abnormal proliferation of the skin and osseous tissues at the distal parts of the extremities. The main clinical features are: a peculiar bulbous deformity of the tips of the digits conventionally described as "clubbing," periosteal proliferation of the tubular bones, and synovial effusions. In most instances, HOA develops a reaction to a severe internal illness, such as lung cancer, cyanotic heart disease, or liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.berh.2020.101507DOI Listing

Digital clubbing as the predominant manifestation of hypertrophic osteoarthropathy caused by pathogenic variants in HPGD in three Indian families.

Clin Dysmorphol 2020 Jul;29(3):123-126

Department of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal.

15-Hydroxyprostaglandin dehydrogenase is NAD-dependent catalytic enzyme involved in prostaglandin biosynthesis pathway encoded by HPGD. The pathogenic variations in HPGD cause primary hypertrophic osteoarthropathy (PHO). The objective of the present study is to identify the genetic basis in patients with digital clubbing due to PHO. Read More

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http://dx.doi.org/10.1097/MCD.0000000000000324DOI Listing
July 2020
0.416 Impact Factor

Hypertrophic pulmonary osteoarthropathy: an unusual manifestation of lung cancer.

QJM 2020 Mar 14. Epub 2020 Mar 14.

Department of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, Japan.

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http://dx.doi.org/10.1093/qjmed/hcaa093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094792PMC

Touraine-Solente-Gole syndrome: Clinical manifestation with bilateral true eyelid ptosis.

JPRAS Open 2019 Sep 27;21:6-13. Epub 2019 Apr 27.

Division of Plastic Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.

Touraine-Solente-Gole syndrome (pachydermoperiostosis [PDP] or primary idiopathic hypertrophic osteoarthropathy [HOA]) is a rare hereditary disorder that is characterized by a triad of manifestations that consists of skin changes (pachydermia), abnormal bone and joint manifestations (periostosis and/or artritis), and digital clubbing (acropachia). Here, we report the case of 24-year-old male who presented with severe bilateral true eyelid ptosis. Physical examination revealed severe ptosis with poor function of the levator palpabrae superioris muscle, thickening of and deep grooves in facial skin (especially at the frontal region), and abnormal appearance of the scalp with accentuating folds and deep furrows (cutis verticis gyrata). Read More

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http://dx.doi.org/10.1016/j.jpra.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061552PMC
September 2019

Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Am J Med Sci 2020 05 26;359(5):312-313. Epub 2019 Dec 26.

Internal Medicine, University of Texas Health Science Center at Houston; Houston, Texas.

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http://dx.doi.org/10.1016/j.amjms.2019.12.010DOI Listing

A 49-Year-Old Man With Cough and Hand, Wrist, and Knee Pain.

Chest 2020 02;157(2):e47-e51

Department of Pulmonary and Critical Care, Drexel University College of Medicine, Philadelphia, PA. Electronic address:

Case Presentation: A 49-year-old man was sent by his primary care physician to the rheumatology clinic with complaints of several months of bilateral lower extremity swelling. The swelling migrated from both ankles up to his knees. Presenting symptoms consisted of bilateral knee pain as well as bilateral wrist and hand pain with swelling. Read More

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http://dx.doi.org/10.1016/j.chest.2019.09.033DOI Listing
February 2020

The pleura and the endocrine system.

Eur J Intern Med 2020 02 7;72:34-37. Epub 2020 Jan 7.

Division of Pulmonary, Critical Care, and Sleep Medicine, Johns Hopkins Hospital, USA.

The functioning of the pleura and the endocrine system are not entirely independent of each other. Some hormones can reach a greater concentration in the pleural exudate than in the blood. However, the clinical significance of this finding remains unknown. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.12.034DOI Listing
February 2020
2.300 Impact Factor

Complete form of pachydermoperiostosis.

An Bras Dermatol 2020 Jan - Feb;95(1):98-101. Epub 2019 Dec 18.

Dermatology Service, Hospital Universit´rio Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis. Its pathogenesis is uncertain and the diagnosis is based on clinical and radiological data. A complete form of the syndrome is reported in a male patient with disease onset in adolescence, with compatible clinical and radiological findings, presenting the three cardinal findings as well as other associated manifestations, such as hyperhidrosis and acne. Read More

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http://dx.doi.org/10.1016/j.abd.2019.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058884PMC

Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature.

Orphanet J Rare Dis 2019 12 26;14(1):297. Epub 2019 Dec 26.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease related to HPGD and SLCO2A1 gene mutation. Gastrointestinal involvement of PHO is even rarer with unknown pathogenesis. Clinical features of GI complication in PHO mimics other auto-immune based bowel entities, such as inflammatory bowel diseases and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Read More

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http://dx.doi.org/10.1186/s13023-019-1264-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933916PMC
December 2019

Digital clubbing occurring in intrathoracic Hodgkin lymphoma: A case report.

Medicine (Baltimore) 2019 Dec;98(51):e18388

Rationale: Digital clubbing is rarely associated with lymphoma. This study reports a case of intrathoracic Hodgkin lymphoma with digital clubbing and reviews the current literature regarding the clinical characteristics of this condition.

Patient Concern: A 21-year-old woman presented with a 3-month history of cough and 1 month of fever, with apparent digital clubbing. Read More

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http://dx.doi.org/10.1097/MD.0000000000018388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940046PMC
December 2019

Touraine-Solente-Gole syndrome.

BMJ Case Rep 2019 Nov 19;12(11). Epub 2019 Nov 19.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

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http://dx.doi.org/10.1136/bcr-2019-232238DOI Listing
November 2019

Paraneoplastic Arthritides: Insights to Pathogenesis, Diagnostic Approach, and Treatment.

J Clin Rheumatol 2019 Nov 15. Epub 2019 Nov 15.

Department of Internal Medicine, University of Cyprus Medical School, Nicosia, Cyprus.

Paraneoplastic arthritides are a group of inflammatory rheumatic syndromes induced by an occult and manifest malignancy, characterized by a wide range of musculoskeletal signs and symptoms that masquerade other rheumatic diseases such as rheumatoid arthritis. Although the pathogenesis of paraneoplastic arthritides is unknown, immune-mediated mechanisms can induce a paraneoplastic syndrome, with a dominant feature the polyarthritis. Common entities of paraneoplastic arthritides include paraneoplastic polyarthritis, hypertrophic osteoarthropathy, remitting seronegative symmetrical synovitis with pitting edema, palmar fasciitis and polyarthritis, and polyarthritis and panniculitis associated with pancreatic carcinoma. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001202DOI Listing
November 2019
1.245 Impact Factor

Schamroth sign.

Authors:
Naoki Matsuura

CMAJ 2019 Nov;191(45):E1251

Department of Internal Medicine, Koga General Hospital, Miyazaki, Japan

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http://dx.doi.org/10.1503/cmaj.190515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861154PMC
November 2019

Hypertrophic Osteoarthropathy in a Patient With Primary Hepatic Angiosarcoma.

Clin Nucl Med 2020 Jan;45(1):57-59

Department of Nuclear Medicine, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

Primary hepatic angiosarcoma was diagnosed in a 59-year-old woman who presented an arthralgia of limbs and dry cough for 6 weeks. Physical examination revealed digital clubbing. A Tc-MDP bone scintigraphy showed diffusely increased uptake along the cortical margins of long bones, suggesting hypertrophic osteoarthropathy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002817DOI Listing
January 2020

A case of primary hypertrophic osteoarthropathy: Management considerations.

Int J Rheum Dis 2019 Nov 24;22(11):2080-2081. Epub 2019 Oct 24.

Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

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http://dx.doi.org/10.1111/1756-185X.13736DOI Listing
November 2019

Impaired bone microarchitecture in distal interphalangeal joints in patients with primary hypertrophic osteoarthropathy assessed by high-resolution peripheral quantitative computed tomography.

Osteoporos Int 2020 Jan 23;31(1):153-164. Epub 2019 Oct 23.

Musculoskeletal Research Laboratory and Bone Quality and Health Assessment Centre, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, 5/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, N.T., Hong Kong, SAR, Hong Kong.

This study aimed to investigate the bone impairment in finger joints in PHO patients by HR-pQCT. Results showed distinguished differences in bone architecture and biomechanics parameters at DIPs between PHO patients and healthy controls using HR-pQCT assessment. Besides, serum PGE2, hsCRP and ESR levels were found negatively correlated with total vBMD. Read More

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http://dx.doi.org/10.1007/s00198-019-05168-3DOI Listing
January 2020

Finger clubbing and cirrhosis in a sarcoidosis patient.

Monaldi Arch Chest Dis 2019 Oct 18;89(3). Epub 2019 Oct 18.

Department of Internal Medicine Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University.

Sarcoidosis is a multisystem granulomatous inflammatory disorder frequently affecting the lungs, but also the liver, along with cirrhosis and portal hypertension occurring in less than 1% of the patients. A 56-year-old female presented with dyspnea, abdominal and leg swelling. Physical examination revealed finger clubbing, ascites and pretibial edema. Read More

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http://dx.doi.org/10.4081/monaldi.2019.1141DOI Listing
October 2019
1 Read

Characteristic Facial Appearance Was the Key to Diagnosing Chronic Enteropathy Associated with SLCO2A1-associated Primary Hypertrophic Osteoarthropathy.

Intern Med 2020 Feb 15;59(4):491-494. Epub 2019 Oct 15.

Department of Gastroenterology, Oita University, Japan.

Patients with chronic enteropathy associated with SLCO2A1 (CEAS) develop multiple circular, longitudinal, or eccentric ulcers in the ileum. It is sometimes difficult to distinguish CEAS from Crohn's disease. CEAS and primary hypertrophic osteoarthropathy (PHO) are together known to be caused by a mutation of SLCO2A1 gene. Read More

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http://dx.doi.org/10.2169/internalmedicine.3369-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056367PMC
February 2020
1 Read

Surgical outcomes and clinical courses of solitary fibrous tumors of pleura.

Niger J Clin Pract 2019 Oct;22(10):1412-1416

Department of Thoracic Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.

Aim: This study's aim is to define the clinicopathological and surgical outcomes, clinical courses, and results of long-term follow-up of cases that underwent surgical treatment for solitary fibrous tumors of the pleura (SFTp).

Subjects And Methods: Clinical and long-term follow-up records of 16 consecutive patients who had surgery for SFTp between 2006 and 2016 were reviewed in the retrospective chart review. There were nine males (56%) and seven (44%) females with an average age of 60. Read More

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http://dx.doi.org/10.4103/njcp.njcp_213_18DOI Listing
October 2019
1 Read

[Paraneoplastic rheumatologic syndromes in the elderly].

Wiad Lek 2019 ;72(9 cz 1):1646-1654

Katedra i Klinika Reumatologii i Układowych Chorób Tkanki Łącznej, Uniwersytet Medyczny w Lublinie, Lublin, Polska.

Risk of development of malignant tumors increases in elderly people. There are numerous clinical symptoms mimicking primary rheumatic diseases in the course of cancers, referred to as paraneoplastic rheumatologic syndromes. They are not caused directly by the tumor or its metastases, but result from the action of biologically active substances released by cancer cells and abnormal immunological reactions. Read More

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October 2019
1 Read

Bisphosphonates use in Pachydermoperiostosis.

J Assoc Physicians India 2019 Sep;67(9):87-90

Resident of Chest Medicine, Cheat and TB Hospital, Govt. Medical College, Patiala, Punjab.

Pachydermoperiostosis is a rare genetic disorder which commonly presents with clubbing, bone pains and skin changes. The treatment is mostly unsatisfactory. We tried bisphosphonates in our case with encouraging results. Read More

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September 2019
8 Reads

Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial.

J Orthop Translat 2019 Jul 31;18:109-118. Epub 2018 Oct 31.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Dongcheng District, Beijing 100730, China.

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease involving joint, bone and skin. Two underlying genes responsible for this disease-hydroxyprostaglandin dehydrogenase () and solute carrier organic anion transporter family, member 2A1 ()-are both associated with aberrant accumulation of prostaglandin E2 (PGE2). Cyclooxygenase-2 (COX-2) is a key enzyme in PGE2 synthesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214031X183010
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http://dx.doi.org/10.1016/j.jot.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718875PMC
July 2019
3 Reads

Dyspnoea, clubbing, cirrhosis, and bubbles in both sides of the heart suggests hepatopulmonary syndrome.

Lancet 2019 Aug 8;394(10197):510. Epub 2019 Aug 8.

Liver Transplant Unit, Austin Hospital, Heidelberg, VIC, Australia.

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http://dx.doi.org/10.1016/S0140-6736(19)31720-9DOI Listing
August 2019
2 Reads

Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice.

Sci Rep 2019 08 1;9(1):11188. Epub 2019 Aug 1.

Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool, L7 8TX, UK.

The structure, ultrastructure and function of hyaline articular cartilage (HAC) and subchondral bone (SCB), and their involvement in the pathogenesis of osteoarthritis (OA) have been extensively researched. However, much less attention has been focused on the intervening tissue, articular calcified cartilage (ACC) and its role in the initiation and progression of OA. Using both light microscopy (LM) and transmission electron microscopy (TEM), a study of ACC in wild type (WT) mice, and mice with genetic osteoarthropathies (AKU) was undertaken to further understand the role played by ACC in the early stages of OA. Read More

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http://dx.doi.org/10.1038/s41598-019-47545-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671989PMC
August 2019
2 Reads

Reversible Hippocratic Fingers in a Patient with Pneumonia.

Am J Med 2020 01 24;133(1):e9-e10. Epub 2019 Jul 24.

Division of Internal Medicine, University Hospital Basel.

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http://dx.doi.org/10.1016/j.amjmed.2019.07.010DOI Listing
January 2020

Hypertrophic Osteoarthropathy in Cystic Fibrosis.

Arthritis Rheumatol 2019 10 27;71(10):1633. Epub 2019 Aug 27.

Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.

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http://dx.doi.org/10.1002/art.41014DOI Listing
October 2019
16 Reads

A young man with progressive worsening dyspnoea

Aust J Gen Pract 2018 12;47(12):856-858

MBBS, FRACP, PhD, Staff Specialist – Respiratory Medicine, Department of Respiratory Medicine, Gold Coast University Hospital, Southport, Qld; Associate Professor, School of Medicine, Griffith University, Southport, Qld

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http://dx.doi.org/10.31128/AJGP-05-18-4579DOI Listing
December 2018
4 Reads

Primary Hypertrophic Osteoarthropathy Mimicking Juvenile Idiopathic Arthritis: A Novel SLCO2A1 Mutation and Imaging Findings.

Cytogenet Genome Res 2019 15;158(3):126-132. Epub 2019 Jun 15.

Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations. Radiographs show distinctive periosteal reaction and thickening along the long bones. PHO is caused by homozygous mutations in the HPGD gene in chromosome 4q34. Read More

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http://dx.doi.org/10.1159/000500988DOI Listing
September 2019
13 Reads

Feet Deformity and Gait Disturbance in a Patient with Pachydermoperiostosis (PDP). Case Study.

Ortop Traumatol Rehabil 2019 Apr;21(2):123-129

Klinika Ortopedii i Ortopedii Dziecięcej, Uniwersytet Medyczny w Łodzi, Polska / Orthopedics and Pediatric Orthopedics Department, Medical University of Łódź, Poland.

Pachydermoperiostosis is a rare condition representing a primary form of hypertrophic osteoarthropathy. It presents in different stages. Patients often overlook early symptoms, because they are benign. Read More

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http://dx.doi.org/10.5604/01.3001.0013.1916DOI Listing
April 2019
8 Reads

Nociceptive pain unmasking a serious pathology - paraneoplastic hypertrophic osteoarthropathy: A case report.

Medicine (Baltimore) 2019 Jun;98(23):e15900

University Emergency Hospital Bucharest, Neurology Department.

Rationale: Hypertrophic osteoarthropathy, also named Pierre Marie-Bamberger syndrome, represents a rare medical condition that may be considered either a primary or a secondary disease, and lung malignancies are responsible for more than two-thirds of the cases with secondary forms of the disease.

Patient Concerns: We present the case of a 41-year-old man referred to our Neurology Department for pain that was considered secondary to cervical disc protrusions. The neurologic examination was normal. Read More

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http://dx.doi.org/10.1097/MD.0000000000015900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571421PMC
June 2019
8 Reads

Voriconazole-associated periostitis presenting as hypertrophic osteoarthropathy following lung transplantation report of two cases and review of the literature.

Semin Arthritis Rheum 2019 10 25;49(2):319-323. Epub 2019 Apr 25.

Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 822, Charleston, SC 29401, USA. Electronic address:

Background: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and osseous tissue frequently associated with underlying pulmonary disorders. Cardinal features include digital clubbing, periostitis and significant joint and bone pain. A number of recent reports have emerged of HOA and periostitis occurring in association with the antifungal agent voriconazole. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.04.003DOI Listing
October 2019
7 Reads

The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation.

Endocr Connect 2019 Jun;8(6):736-744

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare genetic multi-organic disease characterized by digital clubbing, periostosis and pachydermia. Two genes, HPGD and SLCO2A1, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and prostaglandin transporter (PGT), respectively, have been reported to be related to PHO. Deficiency of aforementioned two genes leads to failure of prostaglandin E2 (PGE2) degradation and thereby elevated levels of PGE2. Read More

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http://dx.doi.org/10.1530/EC-19-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547301PMC
June 2019
19 Reads

Hypertrophic osteoarthropathy in an adult macaque.

Int J Paleopathol 2019 06 28;25:39-45. Epub 2019 Apr 28.

Institute of Archaeology, University College London, 31-34 Gordon Square, London, WC1H 0PY, United Kingdom.

Objective: To evaluate through differential diagnosis whether hypertrophic osteoarthropathy was present on an adult macaque skeleton.

Materials: Skeletal remains of a well-preserved adult macaque (Macaca) of unknown species curated by the archaeology department at University College London.

Methods: Macroscopic and radiographic evaluation of pathological lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18799817173013
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http://dx.doi.org/10.1016/j.ijpp.2019.04.002DOI Listing
June 2019
14 Reads

Novel SLCO2A1compound heterozygous mutation causing primary hypertrophic osteoarthropathy with Bartter-like hypokalemia in a Chinese family.

J Endocrinol Invest 2019 Oct 19;42(10):1245-1252. Epub 2019 Apr 19.

Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, 100730, China.

Purpose: Primary hypertrophic osteoarthropathy (PHO) is an inherited disease characterized by digital clubbing, periostosis and pachydermia with defects in the degradation of prostaglandin E2 (PGE2). Mutations in SLCO2A1 gene-encoding prostaglandin transporter (PGT) resulted in PHO, autosomal recessive 2 (PHOAR2). The spectrum of mutations and variable clinical complications of PHOAR2 has been delineated. Read More

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http://dx.doi.org/10.1007/s40618-019-01048-zDOI Listing
October 2019
18 Reads

Acral enlargement without growth hormone excess: a clinical conundrum.

BMJ Case Rep 2019 Apr 11;12(4). Epub 2019 Apr 11.

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1136/bcr-2018-229046DOI Listing
April 2019
3 Reads

Using synovial volume measurement by MRI to evaluate the effect of 32P Radiation synovectomy on hemophilic arthropathy patients.

J Xray Sci Technol 2019 ;27(2):187-195

Department of Radiology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Objective: To evaluate the potential of synovial membrane volume measurement by MRI in monitoring the effect of radiation synovectomy on patients of Hemophilic Arthropathy (HA).

Methods: We studied 63 diseased joints of 42 HA patients who received hospitalized services at the Hemophilia Diagnosis and Treatment Center of Henan Provincial People's Hospital from May 2011 to January 2015. Unenhanced and enhanced MR scanning of each diseased joint was performed simultaneously. Read More

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http://dx.doi.org/10.3233/XST-180480DOI Listing
July 2020
18 Reads

Fourteenth Century Iconography of Digital Clubbing in Prince William II of Aragon (1312-1338).

Chest 2019 04;155(4):880-882

Warwick Medical School, Microbiology and Infection Unit, The University of Warwick; Legal Medicine Section, Department of Public Health and Paediatric Sciences, University of Turin, Turin, Italy; UMR 7268, Laboratoire d'Anthropologie bio-culturelle, Droit, Etique & Santé (Adés), Faculté de Médecine de Marseille, Montigny-Le-Bretonneux, France. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.01.022DOI Listing
April 2019
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A novel mutation in the SLCO2A1 gene in a Chinese family with pachydermoperiostosis.

Australas J Dermatol 2019 Nov 31;60(4):e348-e350. Epub 2019 Mar 31.

Dermatological Department, Hua Zhong University of Science and Technology Affiliated the First Wuhan Hospital, Wuhan, Hubei Province, China.

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http://dx.doi.org/10.1111/ajd.13041DOI Listing
November 2019
9 Reads

Complete form of pachydermoperiostosis with cutis verticis gyrata resulting from the gene mutation.

Indian J Dermatol Venereol Leprol 2019 Nov-Dec;85(6):681

Department of Dermatovenerology, West China Hospital, Sichuan University, Sichuan, China.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_911_17DOI Listing
March 2020
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Review of paraneoplastic syndromes in children.

Pediatr Radiol 2019 04 16;49(4):534-550. Epub 2019 Mar 16.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02215, USA.

Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. Read More

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http://dx.doi.org/10.1007/s00247-019-04371-yDOI Listing
April 2019
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Complete primary pachydermoperiostosis: A case report from Jordan and review of literature.

Clin Case Rep 2019 Feb 9;7(2):346-352. Epub 2019 Jan 9.

Special Surgery Department Jordan University Hospital Amman Jordan.

Complete Primary Pachydermoperiostosis is a rare syndrome that presents with skin and skeletal manifestations. Though diagnosis can be made on the basis of the classic clinical and radiological features, it is often missed due to variable presentations. Therefore, it is important to know about this syndrome to reach correct diagnosis. Read More

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http://dx.doi.org/10.1002/ccr3.1971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389490PMC
February 2019
7 Reads