2,764 results match your criteria Hypertrophic Osteoarthropathy


QJM 2022 Jun 22. Epub 2022 Jun 22.

Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.

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Digital clubbing, joint pain, and skin changes in a young man: primary hypertrophic osteoarthropathy.

Clin Rheumatol 2022 Jun 16. Epub 2022 Jun 16.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universidad de Antioquia, Hospital Universitario de San Vicente Fundación, Calle 10E # 25-165, 050021, Medellín, Colombia.

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Digital Clubbing: Ultrasound Findings.

Actas Dermosifiliogr 2022 05 10;113(5):522-523. Epub 2021 Sep 10.

Servicio de Dermatología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.

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[Abnormal extremities].

Rev Med Interne 2022 May 24. Epub 2022 May 24.

Service de médecine polyvalente, CH de Périgueux, 80, avenue Georges-Pompidou, 24019 Périgueux cedex, France.

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Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with Gene: A KASID Multicenter Study.

Gut Liver 2022 May 25. Epub 2022 May 25.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: Chronic enteropathy associated with gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS.

Methods: From July 2018 to July 2021, we performed Sanger sequencing of the gene in 46 patients with chronic intestinal ulcers. Read More

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Paraneoplastic musculoskeletal disorders: review and update for radiologists.

Skeletal Radiol 2022 May 23. Epub 2022 May 23.

Department of Radiology, University of Washington, 4245 Roosevelt Way NE, Box 354755, Seattle, WA, 98105, USA.

Rheumatic paraneoplastic syndromes are rare syndromes that occur at distant sites from the underlying tumor and may involve the bones, joints, fasciae, muscles, or vessels. In the absence of a known tumor, early recognition of a rheumatic syndrome as paraneoplastic permits dedicated work-up for, and potentially early treatment of an occult malignancy. Although there is a continuously growing list of paraneoplastic rheumatic disorders, not all of these disorders have a well-established association with a neoplastic process. Read More

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Familial Touraine-Solente-Gole syndrome.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, Delhi, India

Touraine-Solente-Gole syndrome is a rare, autosomal dominant multisystem disorder arising from dysregulated prostaglandin synthesis due to underlying genetic defects. Early symptoms are related to skin and soft tissue involvement (coarse facial features, widening of wrists, etc) and may thus be overlooked unless a careful physical examination is carried out. Secondary causes of pachydermoperiosteitis must always be looked for in such patients. Read More

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A Giant Solitary Fibrous Tumour of the Pleura.

Cureus 2022 Apr 12;14(4):e24062. Epub 2022 Apr 12.

Department of Cardiothoracic Surgery, The Essex Cardiothoracic Centre, Basildon & Thurrock University Hospital, Mid and South Essex NHS Foundation Trust, Basildon, GBR.

A solitary fibrous tumour of the pleura (SFTP) is a rare pathology, frequently benign in nature, and is usually diagnosed incidentally on imaging. We herein describe the case of a previously fit and well, 35-year-old Caucasian lady, who presented to us with a history of progressively worsening shortness of breath. Her chest X-ray showed a near-complete opacification of the right hemithorax, with displacement of the mediastinum towards the left. Read More

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Gastrointestinal Multiple Adenomas in Primary Hypertrophic Osteoarthropathy.

Mayo Clin Proc 2022 05;97(5):941-942

Department of General Surgery, Peking University First Hospital, Beijing, China. Electronic address:

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[Surgical Treatment for Lung Cancer Associated with Hypertrophic Pulmonary Osteoarthropathy].

Kyobu Geka 2022 May;75(5):363-367

Department of Thoracic Surgery, Aomori Prefectural Central Hospital, Aomori, Japan.

Hypertrophic pulmonary osteoarthropathy( HPO) is a rare paraneoplastic manifestation of lung cancer that causes joint pain, joint swelling, and limited range of motion. Two surgical cases of lung cancer with HPO are presented. Case1:A 43-year-old female was referred to our department with a diagnosis of cStage ⅡB left hilar lung cancer. Read More

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Primary Hypertrophic Osteoarthropathy.

N Engl J Med 2022 03;386(9):e22

Armed Forces Medical College, Pune, India

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Whole body diffusion weighted imaging with background suppression in pachydermoperiostosis: a case report.

Clin Imaging 2022 Apr 4;84:38-42. Epub 2022 Jan 4.

Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Hypertrophic osteoarthropathy (HOA) is a disease characterized by abnormal skin findings and bone deformities related to subperiosteal bone formation. The disease can be associated with major systemic manifestations (secondary form) or present with absent or less prominent systemic signs and symptoms (primary form). The primary form is called pachydermoperiostosis (PDP). Read More

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A rare helicobacter pylori infection-negative early gastric cancer in a young man with primary hypertrophic osteoarthropathy.

Endoscopy 2022 Jan 26. Epub 2022 Jan 26.

Digestive Endoscopic Center, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.

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January 2022

Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.

J Clin Rheumatol 2022 03;28(2):104-110

Centre for Heart Rythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Abstract: Digital clubbing and hypertrophic osteoarthropathy (HOA) are long-standing clinical entities, but their prevalence have not been synthesized. We aimed to estimate the prevalence of digital clubbing and HOA in people with existing medical conditions.We comprehensively searched PubMed, Embase, and Web of Science to select studies addressing HOA or digital clubbing and published through March 23, 2021. Read More

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Case report: Schizophrenia and hypertrophic osteoarthropathy, a rare syndrome hiding a life-threatening condition.

Clin Case Rep 2022 Jan 12;10(1):e05247. Epub 2022 Jan 12.

Psychiatry Department Razi Psychiatric Hospital Manouba Tunisia.

Schizophrenia is associated to somatic disorders especially cardio-vascular and auto-immune. Through this case report, we describe an association with hypertrophic osteoarthropathy (HPO). For this patient, it was a paraneoplastic syndrome secondary to lung cancer. Read More

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January 2022

Bone Geometry, Density, Microstructure, and Biomechanical Properties in the Distal Tibia in Patients With Primary Hypertrophic Osteoarthropathy Assessed by Second-Generation High-Resolution Peripheral Quantitative Computed Tomography.

J Bone Miner Res 2022 03 3;37(3):484-493. Epub 2022 Jan 3.

Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Periosteosis refers to pathological woven bone formation beneath the cortical bone of the long bones. It is an imaging hallmark of primary hypertrophic osteoarthropathy (PHO) and also considered as one of the major diagnostic criteria of PHO patients. Up to date, detailed information on bone quality changes in long bones of PHO patients is still missing. Read More

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A Case of Lung Adenocarcinoma with Pulmonary Hypertrophic Osteoarthropathy Showing Pathological Complete Response to a Pembrolizumab-Containing Chemoimmunotherapy.

Case Rep Oncol 2021 Sep-Dec;14(3):1380-1386. Epub 2021 Sep 21.

Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada-city, Japan.

A 65-year-old woman with prolonged cough and presumed pulmonary hypertrophic osteoarthropathy was referred to our hospital. Computed tomography showed 2 tumors larger than 3 cm in size and massive hilar lymph node enlargement in the right lung. Pathological examination of the transbronchial lung biopsy specimen showed atypical malignant cells, presumed adenocarcinoma, with 1% positivity of programmed cell death 1 ligand (PD-L1). Read More

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September 2021

Paraneoplastic Syndromes in Lung Cancers: Manifestations of Ectopic Endocrinological Syndromes and Neurologic Syndromes.

Thorac Surg Clin 2021 Nov;31(4):519-537

Hospital of the University of Pennsylvania, Ravdin 6, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Paraneoplastic syndromes are clinical entities associated with cancers and often overlap with metabolic and endocrine syndromes. The cell types of lung cancer involved are frequently small cell, squamous cell, adenocarcinoma, large cell, and carcinoid tumor. A number of neurologic paraneoplastic syndromes have been described for which the tumor product remains unknown. Read More

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November 2021

Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins.

Int Immunopharmacol 2021 Dec 13;101(Pt B):108176. Epub 2021 Oct 13.

Key Laboratory of Physical Fitness and Exercise Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, Hunan 410012, China. Electronic address:

15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2α) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2). As a key enzyme, 15-PGDH catalyzes the rapid oxidation of 15-hydroxy-PGs into 15-keto-PGs with lower biological activity. Increasing evidence suggests that 15-PGDH plays a key role in many physiological and pathological processes in mammals and is considered a potential pharmacological target for preventing organ damage, promoting bone marrow graft recovery, and enhancing tissue regeneration. Read More

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December 2021

Rhytidectomy for pachydermoperiostosis.

Indian J Dermatol Venereol Leprol 2021 Nov-Dec;87(6):863-864

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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February 2022

Chronic Joint Pain in a Young Adult With Cystic Fibrosis.

Cureus 2021 Aug 16;13(8):e17229. Epub 2021 Aug 16.

Pulmonary Medicine, Maine Medical Center, Portland, USA.

A 25-year-old male with end-stage cystic fibrosis (CF) with genotype F508del/F508del presented to the clinic complaining of bilateral knee and ankle pain. He had severe lung disease (forced expiratory volume 1 {FEV1} 19% of predicted), chronic colonization with achromobacter, malnutrition, and CF-related diabetes. On physical examination, he was found to have bilateral knee swelling as well as pain on flexion and extension of the wrists and ankles without erythema or warmth. Read More

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Severe hypoglycemia and finger clubbing in a patient with a BRCA1 mutation in a solitary fibrous tumor: a case report.

Ann Transl Med 2021 Jul;9(13):1093

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Solitary fibrous tumors (SFTs) are rare tumors that stem from mesenchymal cells of submesothelial tissues belonging to the pleura. They can occur in many places such as the spinal canal, intracranial, neck, kidney, liver, pelvis, limbs and other places, most commonly in the chest and abdomen. Pleural SFTs are one of the most common types, and are common in middle-aged people. Read More

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Digital clubbing as first sign of giant solitary fibrous tumor. A case report.

J Surg Case Rep 2021 Aug 4;2021(8):rjab337. Epub 2021 Aug 4.

Department of Surgery, St Luke's Episcopal Medical Center, Ponce, Puerto Rico.

Solitary fibrous tumors are rare pleural tumors. Most of the time they are benign tumors and identified incidentally once they cause symptoms secondary to their mass effect. Here we present an interesting case of a 54-year-old female found with a giant solitary fibrous tumor with signs of hypertrophic pulmonary osteoarthropathy with associated digital clubbing 6 month before identifying the tumor. Read More

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Clubbed Digits Presumably Caused by Lubiprostone.

Intern Med 2021 1;60(15):2499-2502. Epub 2021 Aug 1.

Department of Community Medicine, Ehime University Graduate School of Medicine, Japan.

Digital clubbing has been regarded as an important sign in medicine. A 33-year-old woman with no history of hepatic, pulmonary, or malignant disease was referred to our hospital. She had been taking lubiprostone every day for three years for constipation. Read More

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Clinical Imaging Features of Thyroid Acropachy.

Takafumi Taguchi

Intern Med 2022 Jan 30;61(2):133-134. Epub 2021 Jul 30.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Japan.

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January 2022

The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.

BMC Musculoskelet Disord 2021 Jul 27;22(1):642. Epub 2021 Jul 27.

Orthopedics Ward 3, The General Hospital of Ningxia Medical University, 804 Shengli South Street, Yinchuan, 750004, Ningxia, P.R. China.

Background: Osteoarthritis (OA) is a chronic degenerative disease that suppresses middle-aged and older people worldwide. Silent information regulator 1(SIRT-1) is associated with several age-related diseases, such as cardiovascular diseases, neurodegenerative diseases and tumors, etc. The protective role of SIRT-1 in bone and joint diseases has become increasingly well known. Read More

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Lost bones: differential diagnosis of acro-osteolysis seen by the pediatric rheumatologist.

Pediatr Rheumatol Online J 2021 Jul 14;19(1):113. Epub 2021 Jul 14.

Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

Introduction: Acro-osteolysis is a radiographic finding which refers to bone resorption of the distal phalanges. Acro-osteolysis is associated with various conditions and its presence should prompt the clinician to search for the underlying etiology. The aim of this review is to discuss disorders with which acro-osteolysis is associated and their distinguishing features, with a focus on the pediatric population. Read More

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Hypertrophic osteoarthropathy in renal cell carcinoma - A case report.

Anesth Pain Med (Seoul) 2021 Jul 5;16(3):290-294. Epub 2021 Jul 5.

Department of Anesthesiology and Pain Medicine, Chung-Ang University Hospital, Seoul, Korea.

Background: Hypertrophic osteoarthropathy (HOA) is a rare clinical condition including an abnormal periosteal reaction in the long bones that causes painful swelling and tenderness of the extremities, digital clubbing, arthritis, synovitis, and joint effusions. Most cases are associated with tumorous conditions and most commonly with lung cancer. HOA has been rarely reported in association with other cancers. Read More

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Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations.

J Dermatol 2021 Sep 11;48(9):1442-1446. Epub 2021 Jun 11.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused by mutated HPGD or SLCO2A1. Plasma prostaglandin (PG)E levels are increased in these patients. However, other eicosanoids have not been quantitated. Read More

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September 2021