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    13720 results match your criteria Hypertriglyceridemia

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    Membrane lipid alterations in the metabolic syndrome and the role of dietary oils.
    Biochim Biophys Acta 2017 Apr 18. Epub 2017 Apr 18.
    Bioactive Compunds, Nutrition and Health, Instituto de la Grasa-CSIC, Campus Universidad Pablo de Olavide, Ctra. Utrera km 1, Building 46, 41013 Seville, (Spain).
    The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic syndrome, might be at the same time cause and consequence of impaired lipid composition in plasma membranes of insulin-sensitive tissues like liver, muscle and adipose tissue. Diet intervention has been proposed as a powerful tool to prevent the development of the metabolic syndrome, since healthy diets have been shown to have a protective role against the components of the metabolic syndrome. Read More

    [ASSOCIATION OF AGE OBESITY AND METABOLIC SYNDROME IN MEN].
    Adv Gerontol 2016 ;29(1):86-92
    Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russian Federation.
    The study included 253 men aged 22 to 74 years. Was shown that at the end of the first period of middle age the accumulation of adipose tissue was enhanced that was associated with the change of dominance from the gynoid to the android type of obesity. The most pronounced increase in the frequency of occurrence of individual components and the overall metabolic syndrome was diagnosed in men in the second period of middle age with a following decrease in the frequency such components as hypertriglyceridemia, low HDL cholesterol and hyperglycemia in elderly age. Read More

    Acitretin : A Review of its Pharmacology and Therapeutic Use.
    Drugs 1992 Apr;43(4):597-627
    Adis International Limited, Private Bag 65901, 41 Centorian Drive, Mairangi Bay, Auckland 10, New Zealand.
    Synopsis: Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. Read More

    Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism.
    Front Endocrinol (Lausanne) 2017 4;8:60. Epub 2017 Apr 4.
    University of Colorado School of Medicine, Division of Endocrinology, Metabolism and Diabetes, Aurora, CO, USA.
    Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2 diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic syndrome (MetS). Despite major advances in our understanding of the pathogenesis of these disorders, the prevalence of the MetS continues to rise. It is becoming increasingly apparent that intermediary metabolism within the central nervous system is a major contributor to the regulation of systemic metabolism. Read More

    Phase I Study of Fenretinide Delivered Intravenously in Patients with Relapsed or Refractory Hematologic Malignancies: a California Cancer Consortium Trial.
    Clin Cancer Res 2017 Apr 18. Epub 2017 Apr 18.
    Cancer Center and Departments of Cell Biology & Biochemistry, Pediatrics, and Medicine, School of Medicine, Texas Tech University Health Sciences Center
    Purpose: A phase I study was conducted to determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of fenretinide delivered as an intravenous emulsion in relapsed/refractory hematologic malignancies. 

    Experimental Design: Fenretinide (80 - 1810 mg/m(2)/day) was administered by continuous infusion on Days 1 - 5, in 21-day cycles, using an accelerated titration design. 

    Results: Twenty-nine patients, treated with a median of three prior regimens (range, 1 to 7), were enrolled and received test drug. Read More

    Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis.
    Am J Physiol Endocrinol Metab 2017 Apr 18:ajpendo.00449.2016. Epub 2017 Apr 18.
    Women's Health Academic Centre, King's College London, London, United Kingdom
    Human pregnancy is associated with enhanced de novo lipogenesis in the early stages followed by hyperlipidemia during advanced gestation. Liver X receptors (LXRs) are oxysterol-activated nuclear receptors which stimulate de novo lipogenesis and also promote the efflux of cholesterol from extrahepatic tissues followed by its transport back to the liver for biliary excretion. Although LXR is recognized as a master regulator of triglyceride and cholesterol homeostasis it is unknown whether it facilitates the gestational adaptations in lipid metabolism. Read More

    Post-lunch triglyceridaemia associates with HDLc and insulin resistance in fasting normotriglyceridaemic menopausal women.
    J Hum Nutr Diet 2017 Apr 17. Epub 2017 Apr 17.
    Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.
    Objectives: Post-prandial hypertriglyceridaemia (P-HTG) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high-density lipoprotein-cholesterol (HDLc) and elevated triglyceride (TG) levels. We aimed to provide a self-assesing tool to screen for P-HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean-style eating pattern. Read More

    Nivolumab versus everolimus in advanced renal cell carcinoma: Japanese subgroup analysis from the CheckMate 025 study.
    Jpn J Clin Oncol 2017 Apr 13:1-8. Epub 2017 Apr 13.
    Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: Nivolumab improved overall survival (OS) and objective response rate (ORR) versus everolimus in previously treated patients with advanced renal cell carcinoma in the phase III CheckMate 025 study (minimum follow-up: 14 months). We report efficacy and safety in the global and Japanese populations (minimum follow-up: 26 months).

    Methods: Patients were randomized 1:1 to receive nivolumab 3 mg/kg intravenously every 2 weeks or everolimus 10-mg tablet orally once daily. Read More

    Unraveling the Regulation of Hepatic Metabolism by Insulin.
    Trends Endocrinol Metab 2017 Apr 14. Epub 2017 Apr 14.
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Present address: Internal Medicine, Pfizer Inc., Cambridge, MA, USA. Electronic address:
    During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia and hypertriglyceridemia. Defining the downstream signaling pathways underlying the control of hepatic metabolism by insulin is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. We summarize recent literature highlighting the importance of both hepatic and extrahepatic mechanisms in insulin regulation of liver glucose and lipid metabolism. Read More

    Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach.
    Environ Int 2017 Apr 14;104:48-57. Epub 2017 Apr 14.
    Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada, Spain; University of Granada, Centro de Investigación Biomédica, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain; Oncology Unit, Virgen de las Nieves University Hospital, Spain. Electronic address:
    We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome ("metabolically compromised") was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. Read More

    Recurrent Hypertriglyceridemic Pancreatitis (HTGP); and the Use of Insulin Drip as Treatment.
    J La State Med Soc 2017 Mar-Apr;169(2):55-56. Epub 2017 Apr 15.
    Department of Internal Medicine, Ochsner Medical Center, New Orleans, LA.
    Introduction: Chronic pancreatitis by definition is a recurrent episode of acute pancreatitis and is commonly associated with alcoholism in the US. Another cause of chronic pancreatitis is hypertriglyceridemia (HTGP);, occurring in 1-5 percent of cases. The incidence of HTGP is higher in patients with diabetes and HIV, usually requiring triglyceride levels > 1000 mg/dL. Read More

    Assessment of Lean Patients with Non-alcoholic Fatty Liver Disease in a Middle Income Country; Prevalence and Its Association with Metabolic Disorders: A Cross-sectional Study.
    Arch Iran Med 2017 Apr;20(4):211-217
    Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Recent data has proven that the WHO (world health organization) cut-off for obesity is not applicable to the Asian population. This study aims to estimate the prevalence of lean NAFLD (non-alcoholic fatty liver disease) in the capital of Iran and extract probable predictors for this growing health issue in this population.

    Methods: This is a population-based cross-sectional study on apparently healthy subjects over 18 years of age. Read More

    Severe insomnia is associated with hypertriglyceridemia in women with major depression treated in psychiatry settings.
    J Affect Disord 2017 Apr 9;217:159-162. Epub 2017 Apr 9.
    INSERM UMRS 1178, Team "Depression and Antidepressants", 94275 Le Kremlin Bicêtre, France; Univ. Paris-Sud, Faculté de Médecine Paris Sud, 94275 Le Kremlin Bicêtre, France; Service de Psychiatrie, Hôpital Bicêtre, Hôpitaux Universitaires Paris Sud, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
    Background: Hypertriglyceridemia (HTG) is a cardiovascular risk factor. In the general population, elevated fasting triglyceridemia (TG) is associated with insomnia. Since insomnia is a core symptom of Major Depressive Episodes (MDE), we studied the association of severe insomnia with HTG in major depression. Read More

    Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia.
    Atherosclerosis 2017 Mar 24. Epub 2017 Mar 24.
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
    Background And Aims: Substantial residual cardiovascular risks remain despite intensive statin treatment. Residual risks with high triglyceride and low high-density lipoprotein cholesterol are not the primary targets of statins. K-877 (pemafibrate) demonstrated robust efficacy on triglycerides and high-density lipoprotein cholesterol and a good safety profile as a monotherapy. Read More

    LMNA-associated partial lipodystrophy: anticipation of metabolic complications.
    J Med Genet 2017 Apr 13. Epub 2017 Apr 13.
    Department of Molecular Biology and Genetics, Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
    Background: Type-2 familial partial lipodystrophy (FPLD2) is a rare autosomal dominant lipodystrophic disorder due to mutations in LMNA encoding lamin A/C, a key epigenetic regulator. FPLD2 severity is determined by the occurrence of metabolic complications, especially diabetes and hypertriglyceridaemia. We evaluated the disease history and severity over generations. Read More

    Severe hypertriglyceridemia secondary to venlafaxine use in an older adult on dialysis -case report.
    BMC Health Serv Res 2017 Apr 13;17(1):272. Epub 2017 Apr 13.
    Department of Psychiatry, China Medical University Hospital, No. 2 Yuh-Der Road, Taichung, 40447, Taiwan.
    Background: Although the prescribing information for Venlafaxine extended release includes a discussion about possible increases in total cholesterol and triglycerides (TG) seen in healthier adult patients during premarketing clinical trials, no post-marketing studies or case reports, that discuss the effects of venlafaxine on TG in elderly patients with chronic kidney disease.

    Case Presentation: We report a 71 year-old male patient with end-stage renal disease on hemodialysis, with a history of coronary artery disease, mild hyperlipidemia, and hypertension. This patient twice demonstrated the severe rises in triglycerides while taking the antidepressant, i. Read More

    Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?
    Diabetol Metab Syndr 2017 7;9:22. Epub 2017 Apr 7.
    Department of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, São Paulo, SP 01246-904 Brazil.
    Cardiovascular disease is the leading cause of death in women at advanced age, who are affected a decade later compared to men. Cardiovascular risk factors in women are not properly investigated nor treated and events are frequently lethal. Both menopause and type 2 diabetes substantially increase cardiovascular risk in the female sex, promoting modifications on lipid metabolism and circulating lipoproteins. Read More

    Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
    N Engl J Med 2017 Apr 5. Epub 2017 Apr 5.
    From the Departments of Medicine (A.P.B., M.A.M., N.P.S., X.H., C.M.A., M.L., L.G.F., S.G.Y.), Rheumatology (M.A.M.), Human Genetics (K.R., S.G.Y.), and Pathology and Laboratory Medicine (P.T.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, and the Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, San Francisco (C.R.P.); the Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi (K.M., T.M., M.M., K.N.), and the Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (M.A.) - both in Japan; the Finsen Laboratory, Rigshospitalet, Copenhagen (M.P.); the Department of Medicine, University of Cape Town, Cape Town, South Africa (D.J.B.); the Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville (M.F.L.); the Department of Medicine, Faculty of Medicine, Chulalongkorn University and Thai Red Cross Society, Bangkok, Thailand (W.K.); Clinique de Prévention Cardiovasculaire, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal (R.D.); the Department of Medicine, University of Texas Southwestern Medical Center, Dallas (A.G.); the Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York (I.J.G.); and Fédération d'Endocrinologie, Groupement Hospitalier Est, Hospices Civils de Lyon, INSERM UMR-1060 Carmen, Université de Lyon, Lyon, France (P.M., S.C.).
    Background A protein that is expressed on capillary endothelial cells, called GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1), binds lipoprotein lipase and shuttles it to its site of action in the capillary lumen. A deficiency in GPIHBP1 prevents lipoprotein lipase from reaching the capillary lumen. Patients with GPIHBP1 deficiency have low plasma levels of lipoprotein lipase, impaired intravascular hydrolysis of triglycerides, and severe hypertriglyceridemia (chylomicronemia). Read More

    Severe Hypertriglyceridemia Causing Pancreatitis in a Child with New-onset Type-I Diabetes Mellitus Presenting with Diabetic Ketoacidosis.
    Indian J Crit Care Med 2017 Mar;21(3):176-178
    Department of Clinical Biochemistry, Sri Balaji Action Medical Institute, New Delhi, India.
    The triad of pancreatitis, hypertriglyceridemia, and diabetic ketoacidosis and its treatment has not been extensively discussed in the pediatric literature. We report a 4-year-old child with severe hypertriglyceridemia, pancreatitis, and diabetic ketoacidosis. Hypertriglyceridemia and pancreatitis with diabetic ketoacidosis can be successfully managed with insulin and hydration therapy in children. Read More

    Prevalence of Diet Atherogenicity and Coexistence of Lipid Disorders and Arterial Hypertension among 50-year-old Inhabitants of Wroclaw, Poland.
    Cent Eur J Public Health 2017 03;25(1):15-21
    Department of Dietetics, Wroclaw Medical University, Wroclaw, Poland.
    Objective: The incorrect composition of a diet, its atherogenicity, is conducive to the occurrence of lipid disorders, arterial hypertension (HTN), diabetes, and metabolic syndrome (MetS). The aim of the study was to evaluate the prevalence of incorrect anthropometric and biochemical parameters as well as diet atherogenicity.

    Methods: The study group included 1,520 adults (880 women, 640 men). Read More

    Relationship of lipoprotein lipase gene variants and fasting triglyceride levels in a pediatric population: The CASPIAN-III study.
    Adv Clin Exp Med 2017 Jan-Feb;26(1):77-82
    Physiology Department, Applied Physiology Research Center, Isfahan University of Medical Sciences, Iran.
    Background: Lipoprotein lipase (LPL) is one of the major enzymes responsible for the hydrolysis of triglyceride (TG)-rich lipoprotein. The effects of LPL polymorphisms on serum TG are inconsistent among different populations.

    Objectives: This study aims to assess the TG serum concentration and distributions of three LPL single nucleotide polymorphisms (SNPs), namely D9N, HINDIII and S447X, in a nationally representative sample of Iranian adolescents. Read More

    Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris.
    Heart Vessels 2017 Apr 10. Epub 2017 Apr 10.
    Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
    Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. Read More

    ApoB-lipoproteins and dysfunctional white adipose tissue: Relation to risk factors for type 2 diabetes in humans.
    J Clin Lipidol 2017 Jan - Feb;11(1):34-45.e2. Epub 2016 Oct 3.
    Nutrition Department, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada; Montreal Diabetes Research Center (MDRC), Montréal, Québec, Canada. Electronic address:
    Background: Elevated plasma apoB is an independent predictor of T2D; however, underlying mechanisms remain unclear. Chronic reduction in white adipose tissue (WAT) function promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL induce their dysfunction (decreased hydrolysis and storage of triglyceride-rich lipoproteins [TRL]). Read More

    Estrogen-associated severe hypertriglyceridemia with pancreatitis.
    J Clin Lipidol 2017 Jan - Feb;11(1):297-300. Epub 2016 Dec 23.
    Department of Cardiology and Research Institute, McGill University Health Center, Montreal, Quebec, Canada; Department of Biochemistry and Molecular Genetics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
    Background: Estrogen, whether therapeutic or physiologic, can cause hypertriglyceridemia. Hypertriglyceridemia-induced pancreatitis is a rare complication.

    Cases: We report 2 women who developed estrogen-associated severe hypertriglyceridemia with pancreatitis. Read More

    Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.
    J Clin Lipidol 2017 Jan - Feb;11(1):272-281.e8. Epub 2017 Jan 11.
    Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, Italy; Molecular Biology Diagnostic Laboratory, Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP "Paolo Giaccone", Palermo, Italy. Electronic address:
    Background: Severe hypertriglyceridemia (HTG) may result from mutations in genes affecting the intravascular lipolysis of triglyceride (TG)-rich lipoproteins.

    Objective: The aim of this study was to develop a targeted next-generation sequencing panel for the molecular diagnosis of disorders characterized by severe HTG.

    Methods: We developed a targeted customized panel for next-generation sequencing Ion Torrent Personal Genome Machine to capture the coding exons and intron/exon boundaries of 18 genes affecting the main pathways of TG synthesis and metabolism. Read More

    Effects of MAT9001 containing eicosapentaenoic acid and docosapentaenoic acid, compared to eicosapentaenoic acid ethyl esters, on triglycerides, lipoprotein cholesterol, and related variables.
    J Clin Lipidol 2017 Jan - Feb;11(1):102-109. Epub 2016 Oct 18.
    Department of Medicine, University of Minnesota (Retired), Minneapolis, MN, USA.
    Background: Long-chain omega-3 fatty acid concentrate pharmaceuticals are used in the United States for treatment of severe hypertriglyceridemia (≥500 mg/dL) and are under investigation as adjuncts to statins for lowering cardiovascular risk in patients with high triglycerides (TGs; 200-499 mg/dL).

    Objective: To evaluate MAT9001, an investigational prescription-only omega-3 fatty acid agent containing predominantly eicosapentaenoic acid (EPA) and docosapentaenoic acid, in 42 men and women with fasting TG 200 to 400 mg/dL.

    Methods: In this open-label, crossover trial, subjects received MAT9001 and EPA ethyl esters (EPA-EE) in random order. Read More

    Isolated brachydactyly type E and idiopathic pancreatitis in a patient presenting to a lipid disorders clinic.
    BMJ Case Rep 2017 Apr 6;2017. Epub 2017 Apr 6.
    Department of Clinical Biochemistry, Royal Perth Hospital and Fiona Stanley Hospital Network, Perth, Australia
    An 18-year-old female tertiary student was referred to a lipid clinic with hypertriglyceridaemia discovered after presentation with acute pancreatitis. The patient's only medication was l-thyroxine for treatment of hypothyroidism. She was overweight, normotensive, with unremarkable facies. Read More

    Metabolic Syndrome in Psoriasis among Urban South Indians: A Case Control Study Using SAM-NCEP Criteria.
    J Clin Diagn Res 2017 Feb 1;11(2):WC01-WC04. Epub 2017 Feb 1.
    Junior Resident, Department of Dermatology, K.S Hegde Medical Academy , Mangalore, Karnataka, India .
    Introduction: Psoriasis is a chronic inflammatory disease of the skin associated with increased cardiovascular morbidity. Metabolic syndrome is a significant forecaster of cardiovascular events.

    Aim: To assess the association of metabolic syndrome and its components in patients with psoriasis and to compare it with the age and sex matched control group. Read More

    Therapy of Canine Hyperlipidemia with Bezafibrate.
    J Vet Intern Med 2017 Apr 6. Epub 2017 Apr 6.
    University of California, Davis, CA.
    Background: Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs.

    Objective: To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations.

    Animals: Forty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]). Read More

    An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy.
    Ann Med Surg (Lond) 2017 May 14;17:7-13. Epub 2017 Mar 14.
    Dow University of Health Sciences, Karachi, Pakistan.
    Objective: Recognition of Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome in patients with gallstones undergoing laparoscopic or open cholecystectomy, along with it we will also study the life style of patients with gall stones.

    Background: Patients with gallstones have associated NAFLD, with concurrent metabolic syndrome and these ailments share similar factors for example obesity, hypertriglyceridemia and diabetes mellitus. Factors like body mass index, gender, raised lipid levels, use of contraceptives and alcohol and having diabetes, physical inactiveness, multiparous women, water with excessive iron content, metabolic syndrome, and NAFLD are accountable factors for gallstones formation. Read More

    Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats.
    BMC Vet Res 2017 Apr 4;13(1):85. Epub 2017 Apr 4.
    Department of Production Animal Health, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N4N1, Canada.
    Background: Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats. Client-owned cats were recruited and assigned into 3 study groups: lean, overweight and diabetic. Read More

    PPARα Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil.
    Basic Clin Pharmacol Toxicol 2017 Apr 4. Epub 2017 Apr 4.
    Medical School of Ningbo University, Ningbo, China.
    Gemfibrozil, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely used for hypertriglyceridaemia and mixed hyperlipidaemia. Drug-drug interaction of gemfibrozil and other PPARα agonists has been reported. However, the role of PPARα in Cytochrome P450 (CYP) induction by fibrates is not well known. Read More

    Temporary resolution of insulin requirement in acquired partial lipodystrophy associated with chronic graft-versus-host disease.
    Pediatr Blood Cancer 2017 Mar 29. Epub 2017 Mar 29.
    Florida Hospital, Orlando, Florida.
    This is a case presentation describing a high insulin requirement that suddenly resolved in a patient with acute lymphoblastic leukemia treated with stem cell transplantation complicated by chronic graft-versus-host disease. The patient was diagnosed with acquired partial lipodystrophy that did not require alternative therapies such as leptin or insulin-like growth factor 1. Read More

    Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.
    Pediatr Transplant 2017 May 28;21(3). Epub 2017 Mar 28.
    Division of Pediatric Nephrology, University Children's and Adolescent's Hospital, Cologne, Germany.
    Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Read More

    Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia.
    Nutrients 2017 Apr 1;9(4). Epub 2017 Apr 1.
    Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, UK.
    Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level; which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL); emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. Read More

    Association of non-alcoholic fatty liver disease and cardiometabolic risk factors with early atherosclerosis in an adult population in Southern Italy.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):77-81
    Unità di Medicina, Gastroenterologia e Epatologia, Dipartimento di Scienze della Salute, Ospedale San Paolo, Università degli Studi di Milano, Milan, Italy.
    Aim: The prevalence of risk factors for cardiovascular and metabolic diseases was investigated in an adult population of the city of Cittanova, Southern Italy.

    Methods: The study was conducted among 992 randomly selected adults aged 18-75 years, between April 2009 and January 2011.

    Results: Prevalence rates of non-alcoholic fatty liver disease (NAFLD), overweight, obesity, and metabolic syndrome (MS) were 24. Read More

    PPAR-α Agonist Fenofibrate Reduces Insulin Resistance in Impaired Glucose Tolerance Patients with Hypertriglyceridemia: A Cross-Sectional Study.
    Diabetes Ther 2017 Apr 30;8(2):433-444. Epub 2017 Mar 30.
    Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
    Introduction: Peroxisome proliferator-activated receptor-α (PPAR-α) agonists can regulate metabolism and protect the cardiovascular system. This study investigated the effects of PPAR-α agonist fenofibrate on insulin resistance in patients with impaired glucose tolerance (IGT).

    Methods: This research evaluated cross-sectional and interventional studies. Read More

    Molecular analysis of glycogen storage disease type Ia in Iranian Azeri Turks: identification of a novel mutation.
    J Genet 2017 Mar;96(1):19-23
    Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran.
    Glycogen storage diseases (GSDs) are caused by abnormalities in enzymes that are involved in the regulation of gluconeogenesis and glycogenolysis. GSD I, an autosomal recessive metabolic disorder, is the most common GSD and has four subtypes. Here, we examined GSD Ia caused by the defective glucose-6-phosphatase catalytic (G6PC) gene. Read More

    Paclitaxel and platinum-based chemotherapy results in transient dyslipidemia in cancer patients.
    Mol Clin Oncol 2017 Feb 13;6(2):261-265. Epub 2016 Dec 13.
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, P.R. China.
    Paclitaxel and cisplatin (TP) are common chemotherapeutic agents extensively used for treating lung and esophageal cancers. The present study reported three patients with transient hypertriglyceridemia (HTG) following TP chemotherapy. Serum triglyceride (TG) levels returned to baseline at chemotherapy intermission. Read More

    Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function.
    Int J Chron Obstruct Pulmon Dis 2017 22;12:981-987. Epub 2017 Mar 22.
    Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
    Introduction: Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). The role of PAI-1 in COPD with respect to metabolic and cardiovascular functions is unclear.

    Methods: In this study, which was nested within a prospective cohort study, the serum levels of PAI-1 were cross-sectionally measured in 74 stable COPD patients (Global Initiative for Chronic Obstructive Lung Disease [GOLD] Stages I-IV) and 18 controls without lung disease. Read More

    Hemophagocytic lymphohistiocytosis secondary to hemodialysis catheter-related blood stream infection.
    Indian J Nephrol 2017 Mar-Apr;27(2):133-135
    Department of Clinical Hematology and Oncology, Yashoda Hospitals, Secunderabad, Telangana, India.
    A 57-year-old man on dialysis presented with fever due to Pseudomonas septicemia. Workup revealed very high triglycerides and serum ferritin levels. A bone marrow examination showed hemophagocytosis. Read More

    Enrichment of Triglyceride-Rich Lipoproteins with Apolipoprotein C-I Is Positively Associated with Their Delayed Plasma Clearance Independently of Other Transferable Apolipoproteins in Postmenopausal Overweight and Obese Women.
    J Nutr 2017 Mar 29. Epub 2017 Mar 29.
    Montreal Clinical Research Institute, Montreal, Quebec, Canada;
    Background: The role of plasma apolipoprotein (apo) C-I in cardiometabolic risk in humans is unclear. However, in vitro studies showed a dual role for apoC-I, both protective and harmful, depending on the carrier lipoprotein.Objective: We tested the hypothesis that triglyceride (TG)-rich lipoprotein (TRL) apoC-I, not total or HDL apoC-I, is associated with delayed postprandial plasma clearance of TRLs, independently of apoC-II, apoC-III, and apoE. Read More

    Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study.
    Medicine (Baltimore) 2017 Mar;96(13):e6477
    aDepartment of Internal Medicine, Yeungnam University College of Medicine bDepartment of Internal Medicine, Kyungpook National University School of Medicine cDepartment of Internal Medicine, Keimyung University School of Medicine dDepartment of Internal Medicine, Catholic University of Daegu School of Medicine eDepartment of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.
    The aim of this study was to evaluate sex difference in the prevalence and risk factors for asymptomatic cholelithiasis in Korean health screening examinees.Examinees who underwent examination through health promotion center at 5 hospitals of Daegu-Gyeongbuk province in 2014 were analyzed retrospectively. All examinees were checked for height, weight, waist circumference, and blood pressure, and underwent laboratory tests and abdominal ultrasound. Read More

    Horm Metab Res 2017 03 28;49(3):192-200. Epub 2017 Mar 28.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran.
    The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated. Read More

    Prevalence and Clinical Characteristics of Dyslipidemia in Koreans.
    Endocrinol Metab (Seoul) 2017 Mar;32(1):30-35
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    The prevalence of hypercholesterolemia in Koreans 30 years old and over was 19.5% in 2015 according to the Korean Nutrition and Health Examination Survey, which means that one-fifth of adults had hypercholesterolemia. The prevalence of hypertriglyceridemia in adults 30 years of age and older was 16. Read More

    PPAR-α agonists are still on the rise: an update on clinical and experimental findings.
    Expert Opin Investig Drugs 2017 Apr 11:1-10. Epub 2017 Apr 11.
    b Dipartimento di Scienze Farmacologiche e Biomolecolari , Università degli Studi di Milano , Milan , Italy.
    Introduction: Non-fasting plasma triglyceride (TG) and remnant cholesterol levels, cholesterol content of triglyceride-rich lipoproteins, have been suggested to be an additional cause of cardiovascular diseases; thus, pharmacological TG-lowering with fibrates, activators of PPAR-alpha system, has been linked to risk reduction. Areas covered: This manuscript reviews available evidence on clinical trials involving highly selective PPAR-α agonists (i.e. Read More

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