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    13889 results match your criteria Hypertriglyceridemia

    1 OF 278

    A systematic review of malignancy-associated hemophagocytic lymphohistiocytosis that needs more attentions.
    Oncotarget 2017 Jul 14. Epub 2017 Jul 14.
    Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
    As an infrequent but potentially life-threatening hyperinflammatory syndrome, hemophagocytic lymphohistiocytosis (HLH) is clinically characterized with prolonged fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. Malignancy-associated HLH (M-HLH), one type of acquired HLH, usually presents variable overlaps of symptoms with other types of HLH, thus resulting in higher incidence of misdiagnosis and mortality. In recent years, with the increasing awareness to this disease, the diagnosis and management of HLH have gained more and more attention, and improvements have been made accordingly. Read More

    Effect of Euterpe oleracea Mart. (Açaí) Oil on Dyslipidemia Caused by Cocos nucifera L. Saturated Fat in Wistar Rats.
    J Med Food 2017 Jul 21. Epub 2017 Jul 21.
    1 Drug Research Laboratory, Department of Biological Sciences and Health, College of Pharmacy, Federal University of Amapá , Macapá, Brazil .
    Dyslipidemia is caused by disturbances in lipid metabolism that lead to chronic elevations of serum lipids, especially low-density lipoprotein (LDL)-cholesterol and triglycerides, increasing the risk of metabolic syndrome, obesity, diabetes, atherogenic processes, and cardiovascular diseases. The oil from the fruits of Euterpe oleracea (OFEO) is rich in unsaturated fatty acids with potential for treating alterations in lipid metabolism. In this study, we aimed to investigate the effect of OFEO on hyperlipidemia induced by Cocos nucifera L. Read More

    Lipid-lowering therapy of everolimus-related severe hypertriglyceridaemia in a pancreatic neuroendocrine tumour (pNET).
    J Clin Pharm Ther 2017 Jul 21. Epub 2017 Jul 21.
    Dyslipidemia Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
    What Is Known And Objective: Hypertriglyceridaemia (HTG) is a potentially serious side effect of everolimus therapy. We here report a case of severe HTG in an everolimus-treated patient and provide recommendations for its management.

    Case Summary: The patient was a 70-year-old woman, being treated with everolimus for a pancreatic neuroendocrine tumour (pNET). Read More

    Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study.
    BMC Obes 2017 17;4:29. Epub 2017 Jul 17.
    Non-Communicable Diseases, Research Unit, South African Medical Research Council, Cape Town, South Africa.
    Background: Factors influencing the increasing prevalence of overweight/obesity among children and adolescents in sub-Saharan Africa remain unclear. We assessed the prevalence and determinants of overweight and obesity and effects on cardio-metabolic profile in school learners in the Western Cape, South Africa.

    Methods: Cross-sectional data were collected from 7 to 18-year-old South African school learners attending 14 schools, randomly selected from 107 government schools in the areas. Read More

    Acute Pancreatitis Secondary to Severe Hypertriglyceridemia: Management of Severe Hypertriglyceridemia in Emergency Setting.
    Gastroenterology Res 2017 Jun 30;10(3):190-192. Epub 2017 Jun 30.
    Department of Endocrinology, Bassett Medical Center, Cooperstown, NY, USA.
    Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP). The incidence of AP is around 10-20% with levels > 2,000 mg/dL. We present here a case of a 44-year-old male with history of uncontrolled diabetes mellitus and HTG admitted with severe abdominal pain. Read More

    The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.
    Pharmacol Ther 2017 Jul 16. Epub 2017 Jul 16.
    National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, P.O. Box 12233, MD D2-01, Research Triangle Park, NC 27709, United States. Electronic address:
    The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that upregulate a suite of genes that together promote coordinated mobilization of excess cholesterol from cells and from the body. The LXRs, like other nuclear receptors, are anti-inflammatory, inhibiting signal-dependent induction of pro-inflammatory genes by nuclear factor-κB, activating protein-1, and other transcription factors. Synthetic LXR agonists have been shown to ameliorate atherosclerosis and a wide range of inflammatory disorders in preclinical animal models. Read More

    Obesity and pancreatitis.
    Curr Opin Gastroenterol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
    Purpose Of Review: The obesity pandemic poses a unique set of problems for acute pancreatitis - both by increasing acute pancreatitis incidence, and worsening acute pancreatitis severity. This review explores these associations, underlying mechanisms, and potential therapies.

    Recent Findings: We review how the obesity associated increase in gallstones, surgical, and endoscopic interventions for obesity management, diabetes, and related medications such as incretin-based therapies and hypertriglyceridemia may increase the incidence of acute pancreatitis. Read More

    An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children.
    Sci Rep 2017 Jul 17;7(1):5607. Epub 2017 Jul 17.
    Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
    Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. Read More

    Hypertension, dyslipidemia and cardiovascular risk in HIV infected adults in Poland.
    Kardiol Pol 2017 Jul 17. Epub 2017 Jul 17.
    Uniwersytet Medyczny w Białymstoku.
    Background: Prevalence of cardiovascular diseases (CVD) in HIV infected patients increases with aging and duration of the disease. Hypertension (HA), high cholesterol level obesity, diabetes, tobacco exposure and use of alcohol are among the traditional risk factors that contribute to CVD.

    Aim: was to determinate the incidence of HA, lipid disturbances and CVD risk in dependence on clinical, viral and biochemical factors. Read More

    Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus.
    Cureus 2017 Jun 13;9(6):e1347. Epub 2017 Jun 13.
    Internal Medicine, Jinnah Sindh Medical University (SMC).
    Context: Dyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes.

    Purpose: The main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. Read More

    Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-related Death in Men with Chronic Hepatitis B: A Large Cohort Study.
    Gastroenterology 2017 Jul 12. Epub 2017 Jul 12.
    Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
    Background & Aims: Little is known about the absolute risk of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis B virus (HBV) infection.

    Methods: We collected data from 5373 male Taiwanese civil servants who visited Taiwan's Government Employees' Central Clinics and received routine free physical examinations from 1989 through 1992. We obtained information on liver-related morbidity and mortality in HBV carriers, 40-65 years old (n=1690), with different metabolic risk factors. Read More

    Hypertriglyceridemia, an Underestimated Cardiovascular Risk Factor: An Epidemiological Study of the Rome Area.
    High Blood Press Cardiovasc Prev 2017 Jul 14. Epub 2017 Jul 14.
    FIMMG ASL Roma 3 Distretto X Municipio, Rome, Italy.
    Introduction: Hypertriglyceridemia (triglycerides ≥200 mg/dL) is a major cardiovascular risk factor. Despite the high incidence of this condition in the Italian population, epidemiological information remains limited.

    Aim: To analyze a large database of clinical charts from general practitioners in the Rome area of Italy. Read More

    Metabolic syndrome and its components in Polish women of childbearing age: a nationwide study.
    BMC Public Health 2017 Jul 13;18(1):15. Epub 2017 Jul 13.
    Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
    Background: Abnormal body mass and related metabolic disorders may affect female reproductive health. The purpose of the study was to determine the prevalence of underweight, overweight, obesity, lipid and glucose metabolism disorders, hypertension, and metabolic syndrome, among Polish women of childbearing age.

    Methods: One thousand five hundred eighty-eight non-pregnant Polish women of childbearing age (20-49 years) who participated in the Multi-Centre National Population Health Examination Survey (WOBASZ II study) in 2013-2014, were assigned to 3 age groups: 20-29 years (n = 403), 30-39 years (n = 600) and 40-49 years (n = 585). Read More

    Role of the Polymorphisms of Uncoupling Protein Genes in Childhood Obesity and Their Association with Obesity-Related Disturbances.
    Genet Test Mol Biomarkers 2017 Jul 13. Epub 2017 Jul 13.
    1 Department of Pediatrics, Gaziosmanpasa University School of Medicine , Tokat, Turkey .
    Background: Obesity, one of the most common disorders observed in clinical practice, has been associated with energy metabolism-related protein genes such as uncoupling proteins (UCPs). Herein, we evaluated UCPs as candidate genes for obesity and its morbidities.

    Methods: A total of 268 obese and 185 nonobese children and adolescents were enrolled in this study. Read More

    A possible FTIR-based plasma fingerprint of ACE-I induced reversal of endothelial dysfunction in diabetic mice.
    J Biophotonics 2017 Jul 12. Epub 2017 Jul 12.
    Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.
    Angiotensin-converting enzyme inhibitors (ACE-I) display vasoprotective activity and represent the cornerstone in the treatment of cardiovascular diseases. In the present work we tested whether FTIR-based analysis of blood plasma is sensitive to detect vasoprotective effects of treatment with perindopril including reversal of endothelial dysfunction in diabetes. For this purpose, a plasma samples were collected from untreated db/db mice, db/db mice treated with 2 or 10 mg/kg perindopril and db + mice. Read More

    Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study.
    BMC Obes 2017 3;4:25. Epub 2017 Jul 3.
    TWU-UANL Consortium to Promote Research in Obesity and Obesity-related Diseases, Monterrey, Mexico.
    Background: Metabolic syndrome (MetS) is a major risk factor for cardiovascular disease and diabetes. Previous studies in obese children demonstrating a positive association between serum uric acid (sUA) and components of MetS are confounded by lack of uniformity in age and pubertal status of children. Therefore, we have examined the role of sUA in MetS and its components in pre-pubertal children (Tanner Stage I, age ≤ 9 years). Read More

    Dyslipidemia and its Association with Meibomian Gland Dysfunction: A Systematic Review.
    Int Ophthalmol 2017 Jul 7. Epub 2017 Jul 7.
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL, 33136, USA.
    Purpose: To perform a systematic review of the literature examining the association between meibomian gland dysfunction (MGD) and dyslipidemia.

    Methods: A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here. Read More

    Juvenile-onset generalized lipodystrophy due to a novel heterozygous missense LMNA mutation affecting lamin C.
    Am J Med Genet A 2017 Jul 7. Epub 2017 Jul 7.
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas.
    The LMNA gene contains 12 exons and encodes lamins A and C by alternative splicing within exon 10. While mutations in lamin A specific residues cause several diseases including lipodystrophy, progeria, muscular dystrophy, neuropathy, and cardiomyopathy, only three families with mutations in lamin C-specific residues are reported with cardiomyopathy, neuropathy, and muscular dystrophy so far. We now report two brothers with juvenile-onset generalized lipodystrophy due to a lamin C-specific mutation. Read More

    The prevalence of impaired fasting glucose and undiagnosed diabetes mellitus and associated risk factors among adults living in a rural Koladiba town, northwest Ethiopia.
    BMC Res Notes 2017 Jul 6;10(1):251. Epub 2017 Jul 6.
    Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Diabetes mellitus is becoming a big public health challenge, particularly in developing countries like Ethiopia. It is a manageable disease if early screening and follow up is made. However, as studies in Ethiopia are limited and unorganized, determining the magnitude of prediabetes and diabetes and identifying associated risk factors is quite essential. Read More

    Visceral fat reference values derived from healthy European men and women aged 20-30 years using GE Healthcare dual-energy x-ray absorptiometry.
    PLoS One 2017 6;12(7):e0180614. Epub 2017 Jul 6.
    Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
    Dual energy X-ray absorptiometry (DXA) is an established technique used in clinical and research settings to evaluate total and regional fat. Additionally, recently developed software allow to quantify visceral adipose tissue (VAT). Currently, there are no reference values available for GE Healthcare DXA systems for VAT. Read More

    Elevated Serum Triglycerides in the Prognostic Assessment of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Observational Studies.
    J Clin Gastroenterol 2017 Aug;51(7):586-593
    *Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an †Department of General Surgery, The General Hospital of the People's Liberation Army, Beijing ‡Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
    Background: Hypertriglyceridemia has been positively associated with the risk of acute pancreatitis (AP), but whether increased triglyceride (TG) levels are associated with the severity of AP remains unknown. To this, a meta-analysis was conducted to assess the effect of elevated serum TG on the prognosis of AP.

    Methods: We searched PubMed, EMBASE, and the Cochrane library to identify all eligible studies (up to September 2016). Read More

    Lipid management in India: a nationwide, cross-sectional physician survey.
    Lipids Health Dis 2017 Jul 3;16(1):130. Epub 2017 Jul 3.
    Cipla Ltd, Lower Parel, Mumbai, 400013, India.
    Background: Current international guidelines on dyslipidemia are not concordant on various aspects of management. Also, there are no uniformly accepted Indian guidelines. We, therefore, performed a physician survey to understand lipid management practices in India. Read More

    Significant improvement in triglyceride levels after switching from ritonavir to cobicistat in suppressed HIV-1-infected subjects with dyslipidaemia.
    HIV Med 2017 Jul 3. Epub 2017 Jul 3.
    Foundation Lluita against AIDS, University Hospital Germans Trias i Pujol, Badalona, Spain.
    Objectives: Cobicistat seems to have a low rate of adverse events compared with ritonavir.

    Methods: This restrospective observational study to evaluated changes in lipid parameters and the percentage of subjects with dyslipidemia in virologically suppressed HIV-infected patients who were receiving a regimen containing darunavir/ritonavir and were then switched from ritonavir to cobicistat, carried out from December 2015 to May 2016, included 299 HIV-1-infected patients who were on stable antiretroviral treatment including darunavir/ritonavir (monotherapy, bitherapy or triple therapy for at least 6 months) and were then switched from ritonavir to cobicistat. Lipid parameters, as well as plasma HIV-1 RNA and CD4 cell counts, were recorded at baseline just before the switch, and 24 weeks after the switch. Read More

    Plasmapheresis for recurrent acute pancreatitis from hypertriglyceridemia.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):358-359
    Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
    Acute pancreatitis is a known complication of severe hypertriglyceridemia. Therapeutic experience with plasmapheresis is less well reported but has been highly successful in life-threatening presentations. We describe a 38-year-old obese Hispanic woman with a previous history of acute pancreatitis from diabetic hypertriglyceridemia who presented to the emergency department with a 2-day history of worsening abdominal pain. Read More

    Pharmacologic approaches for the management of patients with moderately elevated triglycerides (150-499 mg/dL).
    J Clin Lipidol 2017 Jun 6. Epub 2017 Jun 6.
    Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.
    Hypertriglyceridemia, defined as serum triglyceride (TG) levels >150 mg/dL, now affects over one-quarter of the US adult population and is associated with an increased risk of atherosclerotic cardiovascular disease. Available guidelines for managing hypertriglyceridemia vary with respect to TG thresholds and severity of disease. Lifestyle modifications and management of secondary causes (eg, diabetes) remain the first step in managing hypertriglyceridemia, with pharmacotherapy reserved to reduce the risk of pancreatitis and/or further reduce TG levels. Read More

    Association of Hypertriglyceridemia With the Incidence and Progression of Chronic Kidney Disease and Modification of the Association by Daily Alcohol Consumption.
    J Ren Nutr 2017 Jun 28. Epub 2017 Jun 28.
    Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD), based on the Individual Risk Assessment by Specific Health Checkup, The Ministry of Health, Labour and Welfare of Japan, Fukushima, Japan.
    Objective: The association of serum triglycerides (TGs) and alcohol consumption with chronic kidney disease (CKD) is unclear. The purpose of this study was to investigate the association of serum TG and daily alcohol consumption with CKD in the general population.

    Design: The design of the study was longitudinal cohort study. Read More

    A 28-year-old woman with fever, rash, and pancytopenia.
    Allergy Asthma Proc 2017 Jul;38(4):322-327
    A 28-year-old Hispanic woman was admitted to the hospital with fever, sore throat, arthralgia, and a generalized rash of 2 weeks' duration. Her medical history was significant for various food and medication allergies. Multiple antibiotics were given for suspected infection, and she subsequently developed a new skin rash, acute liver injury, eosinophilia, and pancytopenia. Read More

    GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.
    J Clin Lipidol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:
    Background: GPIHBP1, a glycolipid-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the interstitial spaces and transports it to the capillary lumen. GPIHBP1 deficiency prevents LPL from reaching the capillary lumen, resulting in low intravascular LPL levels, impaired intravascular triglyceride processing, and severe hypertriglyceridemia (chylomicronemia). A recent study showed that some cases of hypertriglyceridemia are caused by autoantibodies against GPIHBP1 ("GPIHBP1 autoantibody syndrome"). Read More

    The alcohol extract of North American ginseng (Panax quinquefolius) reduces fatty liver, dyslipidemia, and other complications of metabolic syndrome in a mouse model.
    Can J Physiol Pharmacol 2017 Jun 30. Epub 2017 Jun 30.
    University of Guelph , 346 - ANNU Bldg. , Guelph, Ontario, Canada , N1G 2W1 ;
    We investigated if the North American ginseng could reduce development of the metabolic syndrome phenotype in a mouse model (ETKO) of the disease. Young ETKO has no disease but similarly to humans starts to develop the fatty liver, hypertriglyceridemia, obesity, and insulin resistance at 25-30 weeks of age, and the disease continues to progress by ageing. ETKO mice were given orally an ethanol extract of ginseng roots at 4 weeks and 32 weeks of age. Read More

    Can Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease Co-Exist?
    J Clin Exp Hepatol 2017 Jun 3;7(2):121-126. Epub 2017 Feb 3.
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
    Background: Nonalcoholic fatty liver disease (NAFLD) by definition would require exclusion of significant alcohol intake. Present study was aimed to assess the prevalence of various components of metabolic syndrome (MS) in patients with alcoholic cirrhosis (AC) and to study the affect of its presence on the severity of liver disease, testing the hypothesis if alcoholic liver disease (ALD) and NAFLD could co-exist.

    Methods: In a retrospective analysis of 16 months data, 81 patients with AC were analysed for the prevalence of MS. Read More

    Serum Gamma-Glutamyl Transferase and Ferritin Synergistically Associated with the Rate of Chronic Kidney Disease.
    Dis Markers 2017 4;2017:9765259. Epub 2017 Jun 4.
    Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China.
    The present study investigated the effects of GGT and SF on the risk of CKD. 1024 participants (436 men and 588 women) were divided into three groups according to GGT and SF levels: group 1 (both GGT and SF not in the fourth quartile), group 2 (only GGT or SF in the fourth quartile), and group 3 (both GGT and SF in the fourth quartile). The risks of CKD in different levels of GGT and SF and in groups 2-3 compared with group 1 were analyzed by multiple logistic regression. Read More

    Prevalence of Non Alcoholic Fatty Liver Disease and its Association with Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus.
    J Clin Diagn Res 2017 May 1;11(5):OC04-OC07. Epub 2017 May 1.
    Endocrinologist, Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.
    Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus (T2DM) are two common problems affecting global health as these two conditions can influence each other. There is very little information about the possible association between NAFLD and diabetic microvascular complications such as diabetic nephropathy.

    Aim: The aim of this study was to evaluate the prevalence of NAFLD in patients with T2DM and to investigate the association between NAFLD and diabetic nephropathy in these patients. Read More

    The prevalence of metabolic syndrome and its components among overweight and obese Nigerian adolescents and young adults.
    Niger J Clin Pract 2017 Jun;20(6):670-676
    Department of Paediatrics, Benjamin S. Carson (Snr) School of Medicine, Babcock University and Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria.
    Background: The incidence of metabolic syndrome (MetS), is rapidly increasing in developing countries. However, the epidemiology of MetS is not well reported in the pediatric and young adult population. We determined the prevalence of MetS and its components among overweight and obese Nigerian adolescents and young adults presenting for university admission. Read More

    Stratified analysis and clinical significance of elevated serum triglyceride levels in early acute pancreatitis: a retrospective study.
    Lipids Health Dis 2017 Jun 27;16(1):124. Epub 2017 Jun 27.
    Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
    Background: Hypertriglyceridemia is one of the three most common causes of AP, which is associated with the AP prognosis that has not been clearly defined.

    Methods: In this retrospective study, 1539 AP patients, who had serum triglyceride (TG) levels measured within the first 72 h, were assessed. The study groups consisted of patients with normal, mild, moderate, and severe/very severe HTG levels based on the Endocrine Society Clinical Practice Guidelines. Read More

    Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling.
    Oncotarget 2017 Jun 16. Epub 2017 Jun 16.
    The Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, China.
    Maternal obesity influence the child's long-term development and health. Though, the mechanism concerned in this process is still uncertain. In the present study, we explored whether overfeeding of a high-fat diet during pregnancy in female rats altered metabolic phenotypes in an F1 generation and authenticated the contribution of hypothalamic leptin signaling. Read More

    Sugar-Sweetened Beverages Consumption Positively Associated with the Risks of Obesity and Hypertriglyceridemia Among Children Aged 7-18 Years in South China.
    J Atheroscler Thromb 2017 Jun 23. Epub 2017 Jun 23.
    Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University.
    Aims: Excessive consumption of sugar-sweetened beverages (SSBs) may increase the prevalence of obesity and other metabolic risk factors. However, data regarding the relationship between SSB consumption and metabolic risk factors are insufficient in Chinese children. Hence, we aimed to explore the association between SSB consumption and cardio-metabolic risk factors in children aged 7-18 years living in South China. Read More

    Relationship between simple markers of insulin resistance and coronary artery calcification.
    J Clin Lipidol 2017 Jun 6. Epub 2017 Jun 6.
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
    Background: Insulin resistance in apparently healthy persons is associated with a cluster of metabolic abnormalities that promote coronary atherosclerosis. Identifying these individuals before manifest disease would provide useful clinical information.

    Objective: We hypothesized that combining 2 simple markers of insulin resistance, prediabetes (PreDM) and triglyceride (TG) concentration ≥150 mg/dL, would identify apparently healthy persons with adverse cardiometabolic risk profiles and increased coronary artery calcium (CAC) compared with those with neither or only 1 abnormality. Read More

    [Mycosis fungoides in a heart transplant recipient].
    Ann Dermatol Venereol 2017 Jun 22. Epub 2017 Jun 22.
    Service de dermatologie, groupe hospitalier du Havre, hôpital J.-Monod, BP 24, 76083 Le Havre, France.
    Background: Skin cancer occurs frequently in organ transplant patients as a result of induced immunosuppression. Most cases involve carcinomas or B-cell lymphomas induced by the Epstein Barr virus (EBV). Cutaneous T-cell lymphomas remain rare. Read More

    Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study.
    Clin Nutr 2017 Jun 8. Epub 2017 Jun 8.
    Department of Biochemistry and Molecular Biology, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Spain.
    Background: Hypertriglyceridemia is common in HIV-infected patients. Polyunsaturated fatty acids reduce fasting serum triglyceride (TG) levels in HIV-infected patients. It is not known whether docosahexanoic acid (DHA) supplementation can reduce hypertriglyceridemia and modify fat distribution in HIV-infected patients. Read More

    [Prevalence of hypertension and risk factors in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Jun;38(6):709-714
    Office of Director, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
    Objective: To investigate the prevalence of hypertension and risk factors in Uygur adults in Kashgar of Xinjiang. Methods: A total of 4 748 Uygur adults aged ≥18 years selected through cluster random sampling in Shufu county of Kashgar prefecture were surveyed by means of questionnaire survey, physical examination and laboratory test. The prevalence, awareness, treatment and control rate of hypertension of different groups were calculated and risk factors of hypertension was analyzed by using non-conditional logistic regression model. Read More

    Dynapenic obesity as an associated factor to lipid and glucose metabolism disorders and metabolic syndrome in older adults - Findings from SABE Study.
    Clin Nutr 2017 Jun 10. Epub 2017 Jun 10.
    Department of Epidemiology, University of São Paulo, São Paulo, Brazil.
    Background & Aims: There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo.

    Methods: This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010. Read More

    The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model.
    Pancreatology 2017 Jun 12. Epub 2017 Jun 12.
    Department of SICU, Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
    Objective: The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis.

    Methods: Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Read More

    The Patient's Comorbidity Burden Correlates with the Erectile Dysfunction Severity.
    Actas Urol Esp 2017 Jun 19. Epub 2017 Jun 19.
    Departamento of Urología, Hospital Clínic de Barcelona, Barcelona, España.
    Objective: To explore the potential relationship between erectile dysfunction (ED), low testosterone levels, and the Charlson Comorbidity Index (CCI).

    Material And Methods: Cross-sectional study on patients referred to the andrology unit in 7 Spanish centers. The ED was diagnosed and graded using the International Index of Erectile Function (IIEF-5) score. Read More

    Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: Experience from a multicenter, observational study.
    Epilepsy Behav 2017 Jun 19;73:173-179. Epub 2017 Jun 19.
    Hospital Universitario Ramón y Cajal, Servicio de Neurología, Madrid, Spain. Electronic address:
    Eslicarbazepine acetate (ESL, Aptiom™) is a once-daily anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). Historical-controlled trials investigating the use of ESL as monotherapy have demonstrated a favorable efficacy and tolerability profile in patients with POS. This prospective, non-interventional study recruited POS patients in 17 hospitals in Spain. Read More

    Specificity of, and influence of hemolysis, lipemia, and icterus on serum lipase activity as measured by the v-LIP-P slide.
    Vet Clin Pathol 2017 Jun 21. Epub 2017 Jun 21.
    Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
    Background: Measurement of pancreatic lipase in serum is being used for the diagnosis of pancreatitis.

    Objectives: The aims of this study were to measure serum lipase activity by the v-LIP-P slide and serum canine pancreatic lipase immunoreactivity (cPLI) concentration by Spec cPL in dogs with exocrine pancreatic insufficiency (EPI) and in serum samples that were hemolyzed, lipemic, or icteric.

    Methods: Serum samples from 50 dogs with EPI, 8 samples spiked with canine hemoglobin, Intralipid, or ditaurobilirubin, and 8 samples from dogs with severe hypertriglyceridemia were evaluated using v-LIP-P and Spec cPL assays. Read More

    Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.
    Nutrients 2017 Jun 21;9(6). Epub 2017 Jun 21.
    Center of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal.
    Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (n = 10)-received 35% of sucrose in drinking water; Control (n = 12)-received vehicle (water). Read More

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