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    13794 results match your criteria Hypertriglyceridemia

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    Prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador.
    Diabetes Metab Syndr 2017 May 15. Epub 2017 May 15.
    Universidad Católica de Santiago de Guayaquil, Ave. Carlos julio Arosemena, Guayaquil, Ecuador.
    Aims: To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador.

    Materials And Methods: The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the association of abdominal obesity with cardio metabolic risk factors. Read More

    Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis.
    Oncotarget 2017 May 10. Epub 2017 May 10.
    Department of Endocrinology and Metabolic Diseases, The Affiliated Hospital of Qingdao University, Qingdao, China.
    Lipoprotein lipase (LPL) is widely expressed in skeletal muscles, cardiac muscles as well as adipose tissue and involved in the catabolism of triglyceride. Herein we have systematically characterized two novel loss-of-function mutations in LPL from a Chinese family in which afflicted members were manifested by severe hypertriglyceridemia and recurrent pancreatitis. DNA sequencing revealed that the proband was a heterozygote carrying a novel c. Read More

    Hypertriglyceridemic acute pancreatitis in an Emergency Department: the typical clinical features and genetic variants.
    J Dig Dis 2017 May 26. Epub 2017 May 26.
    Department of Emergency Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, 160# Pujian Rd, Pudong new District, Shanghai, China, 200127.
    Objective: To investigate the clinical characteristics of hypertriglyceridemic acute pancreatitis (HTGAP), and the molecular foundation contributing to the hypertriglyceridemia in this group of patients.

    Methods: Clinical data from 329 patients with AP were collected and analyzed. All the patients were divided into 1) HTGAP group (n = 40), with fasting serum triglyceride ≥ 500 mg/dL; and 2) NHTGAP group (n = 289). Read More

    Constitutive activation of AKT2 in humans leads to hypoglycemia without fatty liver or metabolic dyslipidemia.
    J Clin Endocrinol Metab 2017 May 23. Epub 2017 May 23.
    The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.
    Context: The activating p.Glu17Lys mutation in AKT2, a kinase mediating many of insulin's metabolic actions, causes hypoinsulinemic hypoglycemia and left-sided hemihypertrophy. The wider metabolic profile and longer term natural history of the condition has not yet been reported. Read More

    Childhood Obesity Is a High-risk Factor for Hypertriglyceridemia: A Case-control Study in Vietnam.
    Osong Public Health Res Perspect 2017 Apr 30;8(2):138-146. Epub 2017 Apr 30.
    Hanoi National University of Education, Hanoi, Vietnam.
    Objectives: To investigate the relationship between dyslipidemia and obesity status among Viet-namese adolescents.

    Methods: In this case-control study, 282 adolescents (6-11 years), including 88 obese cases and 194 normal-weight controls, were recruited from a population-based cross-sectional study from two provinces in Vietnam. The anthropometric, blood lipid, and other laboratory test results of the study subjects were analyzed. Read More

    The KSR2-rs7973260 Polymorphism is Associated with Metabolic Phenotypes, but Not Psychological Phenotypes, in Chinese Elders.
    Genet Test Mol Biomarkers 2017 May 24. Epub 2017 May 24.
    5 Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine , Shanghai, China .
    Objective: To examine the associations between genetic variants KSR2 (kinase suppressor of RAS)-rs7973260, RAPGEF6 (guanine nucleotide exchange factor 6)-rs3756290, LOC105377703-rs4481363, and subjective well-being (SWB) and depressive symptoms (DSs) in Chinese elders, which were recently associated in a genome-wide association study conducted in Caucasians. The pleiotropic effects of KSR2-rs7973260 on metabolic phenotypes were also explored.

    Materials And Methods: We used data of 1788 older individuals aged 70-84 years from the aging arm of the Rugao Longevity and Aging Study, a population-based cohort study conducted in the Jiangsu province of China. Read More

    Do Patients With a Baseline Clinical Condition Warranting the Cautious Use of Parenteral Nutrition Develop Subsequent Metabolic Complications?
    Nutr Clin Pract 2017 Jun 1;32(3):400-406. Epub 2016 Dec 1.
    1 Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, USA.
    Background: The American Society for Parenteral and Enteral Nutrition Adult Nutrition Support Core Curriculum describes clinical conditions that warrant cautious use of parenteral nutrition (CCWCPN). The Core Curriculum authors acknowledge there is no evidence for specific criteria suggested for the clinical conditions. Consequently, the purpose of this study was to determine the impact of a baseline CCWCPN on the development of subsequent metabolic complications in patients receiving parenteral nutrition (PN). Read More

    Body mass index growth trajectories associated with the different parameters of the metabolic syndrome at adulthood.
    Int J Obes (Lond) 2017 May 22. Epub 2017 May 22.
    From Paris 13 University, Nutritional Epidemiology Research Team, French National Institute of Health and Medical Research (Inserm) U1153, French National Institute for Agricultural Research (Inra) U1125, French National Conservatory of Arts and Crafts (CNAM), Sorbonne Paris Cité University, Bobigny, France.
    Background: Growth trajectories have shown to be related to obesity and metabolic risks in later life, however body mass index (BMI) trajectories according to the presence or absence of metabolic syndrome (MS) and its parameters in adulthood are scarce in literature.

    Objectives: To investigate BMI trajectories during childhood in relation to MS and its parameters in adult age.

    Methods: A total of 1919 subjects (43. Read More

    Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats.
    Endocrine 2017 May 19. Epub 2017 May 19.
    Laboratory of Endocrine Physiology, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Purpose: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Read More

    Association between prepregnancy obesity and metabolic risk in Chilean premenopausal women 10 y postpartum.
    Nutrition 2017 Jun 12;38:20-27. Epub 2017 Jan 12.
    Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
    Objectives: One of every four pregnant women in Chile is obese. Gestational obesity is associated with maternal metabolic complications in pregnancy (e.g. Read More

    Prevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease.
    Dig Dis Sci 2017 May 18. Epub 2017 May 18.
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
    Background/aims: Transient elastography (TE) can be used to assess the degree of liver fibrosis and steatosis. We investigated the prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) with or without significant liver fibrosis in the general population.

    Methods: A total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. Read More

    Frequency of Dyslipidemia in patients with Lupus Nephritis.
    Pak J Med Sci 2017 Mar-Apr;33(2):358-362
    Bilal Azeem Butt, FCPS (Medicine), Division of Rheumatology, Fatima Memorial College of Medicine & Dentistry, University of Health Sciences, Lahore, Pakistan.
    Objective: To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria.

    Methods: This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from 21(st) Sep 2016 to 20(th) Dec 2016. After 12 hours overnight fast their blood samples were assessed for total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Read More

    Dysbiosis of Intestinal Microbiota and Decreased Antimicrobial Peptide Level in Paneth Cells during Hypertriglyceridemia-Related Acute Necrotizing Pancreatitis in Rats.
    Front Microbiol 2017 4;8:776. Epub 2017 May 4.
    Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China.
    Hypertriglyceridemia (HTG) aggravates the course of acute pancreatitis (AP). Intestinal barrier dysfunction is implicated in the pathogenesis of AP during which dysbiosis of intestinal microbiota contributes to the dysfunction in intestinal barrier. However, few studies focus on the changes in intestine during HTG-related acute necrotizing pancreatitis (ANP). Read More

    [Severe hypertriglyceridemia : Diagnostics and new treatment principles].
    Internist (Berl) 2017 May 17. Epub 2017 May 17.
    Charité, Universitätsklinik Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.
    Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For diagnosis, secondary factors have to be excluded and treated before further genetic tests are considered. Typical symptoms in almost all patients are recurrent, sometimes severe abdominal pain attacks, which can result in acute pancreatitis, the most important, sometimes life-threatening complication. Read More

    Replacement of Refined Starches and Added Sugars with Egg Protein and Unsaturated Fats Increases Insulin Sensitivity and Lowers Triglycerides in Overweight or Obese Adults with Elevated Triglycerides.
    J Nutr 2017 May 17. Epub 2017 May 17.
    Midwest Biomedical Research/Center for Metabolic and Cardiovascular Health, Glen Ellyn, IL; and.
    Background: Hypertriglyceridemia is a common condition in the United States and is often associated with other metabolic disturbances, including insulin resistance, metabolic syndrome, and a predominance of small dense LDL particles.Objective: The objective of this trial was to evaluate the effects of a combination of egg protein (Epro) and unsaturated fatty acids (UFAs) substituted for refined starches and added sugars on insulin sensitivity (primary outcome) and other cardiometabolic health markers in overweight or obese adults with elevated triglyceride (TG) concentrations.Methods: Subjects with elevated TG concentrations were given test foods prepared by using Epro powder (∼8% of energy) and vegetable oil (∼8% of energy; Epro and UFA condition) or test foods prepared by using refined starch and sugar (∼16% of energy; carbohydrate condition) in a randomized, double-blind, controlled-feeding, crossover trial (3 wk/condition, 2-wk washout). Read More

    Light Chain Myeloma induced Severe Hypertriglyceridemia.
    J Clin Diagn Res 2017 Mar 1;11(3):OD01-OD03. Epub 2017 Mar 1.
    Professor, Department of Medicine, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Hyperlipidemia is very common in general population and incidence has further increased in recent years. Evaluation of patient presenting with lipid disorders is essential to obtain a definite diagnosis to prevent complications, and apply the most appropriate treatment. An isolated elevation in triglyceride levels may be caused by a primary disorder of lipid metabolism like familial hypertriglyceridemia. Read More

    Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial.
    J Clin Diagn Res 2017 Mar 1;11(3):OC13-OC16. Epub 2017 Mar 1.
    Medical Officer, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.
    Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level.

    Aim: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients. Read More

    Atherosclerotic vascular diseases have really the same risk factors? Comparison between large abdominal aortic aneurysm and obstructive non-coronary arterial disease.
    Vascular 2017 Jan 1:1708538117708474. Epub 2017 Jan 1.
    Dipartimento di Medicina Interna e, Scienze Biomediche, Sezione di Cardiologia, Università degli Studi di Parma, Parma, Italy.
    Objectives The purpose of this study was to investigate whether there are differences among clinical conditions and traditional atherosclerotic risk factors between patients with large abdominal aortic aneurysm and those with occlusive non-coronary arterial disease. Methods We clinically examined 519 patients with asymptomatic abdominal aortic aneurysm and 672 with severe obstructive arterial diseases before surgical repair. Results In patients with abdominal aortic aneurysm, we identified a clear predominance of males ( p < 0. Read More

    Fatty liver as a risk factor for progression from metabolically healthy to metabolically abnormal in non-overweight individuals.
    Endocrine 2017 May 16. Epub 2017 May 16.
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
    Purpose: Recent studies identified that metabolically abnormal non-obese phenotype is a risk factor for cardiovascular diseases. However, little is known about risk factor for progression from metabolically healthy non-overweight to metabolically abnormal phenotype. We hypothesized that fatty liver had a clinical impact on progression from metabolically healthy non-overweight to metabolically abnormal phenotype. Read More

    Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature.
    Ther Adv Endocrinol Metab 2017 Apr 1;8(4):59-65. Epub 2017 Feb 1.
    Assistant Professor, Pulmonary, Critical Care and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room G-228, Memphis, TN 38163, USA.
    Background: Severe hypertriglyceridemia (HTG) is the third leading cause of acute pancreatitis (AP) in the United States. The current standard of care includes management of HTG using pharmacological therapy. More recently, plasmapheresis has been proposed as a therapeutic tool for decreasing triglyceride (TG) levels, especially in critically ill patients. Read More

    Long-term outcomes in children with chronic kidney disease stage 5 over the last 40 years.
    Arch Med Sci 2017 Apr 20;13(3):635-644. Epub 2017 Apr 20.
    Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: We evaluated outcomes in children with chronic kidney disease stage 5 (CKD 5) treated in the first pediatric dialysis unit in Poland during 1973-2012.

    Material And Methods: The retrospective analysis included 208 children with CKD 5 undergoing renal replacement therapy (RRT), stratified into four decades of treatment: 1973-1982, 1983-1992, 1993-2002, and 2003-2012.

    Results: The most common causes of CKD 5 included glomerulonephritis in 27. Read More

    Assessment of pharmacokinetic interaction between omega-3 carboxylic acids and the statins rosuvastatin and simvastatin: Results of 2 phase I studies in healthy volunteers.
    J Clin Lipidol 2017 May - Jun;11(3):739-748. Epub 2017 Apr 5.
    Quantitative Clinical Pharmacology, AstraZeneca Gothenburg, Mölndal, Sweden.
    Background: Omega-3 carboxylic acids (OM3-CA) can lower triglyceride levels. OM3-CA is often prescribed concomitantly with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin).

    Objective: The aim of the article was to assess the potential for pharmacokinetic interaction between OM3-CA and the statins rosuvastatin and simvastatin. Read More

    Serum triglyceride, high-density lipoprotein cholesterol, apolipoprotein B, and coronary heart disease in a Chinese population undergoing coronary angiography.
    J Clin Lipidol 2017 May - Jun;11(3):646-656. Epub 2017 Mar 18.
    Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, Shanghai, China. Electronic address:
    Background: Increased serum triglyceride and apolipoprotein B (apoB) levels and decreased high-density lipoprotein cholesterol (HDL-C) levels are risk factors for cardiovascular diseases. The major types of dyslipidemia in Chinese population are hypertriglyceridemia and low HDL-C.

    Objective: This study aimed to evaluate the effect of HDL-C, triglyceride, and apoB levels on the risk of coronary heart disease (CHD) in a Chinese population undergoing coronary angiography. Read More

    Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy.
    J Clin Lipidol 2017 Mar - Apr;11(2):543-550. Epub 2017 Feb 24.
    Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIH, Bethesda, MD, USA.
    Background: Reduced triglyceride clearance due to impaired lipoprotein lipase-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting lipoprotein lipase. Whether circulating ANGPTL3/4 levels are altered in lipodystrophy and the effects of leptin replacement on these ANGPTLs are unknown. Read More

    Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid Technologies(TM) (ALT(®))-based formulation.
    J Clin Lipidol 2017 Mar - Apr;11(2):394-405. Epub 2017 Feb 9.
    Sancilio & Company, Inc (SCI), Riviera Beach, FL, USA.
    Background: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by food effect. SC401 is a novel Advanced Lipid Technologies-based formulation of EPA-EE and DHA-EE. Read More

    A novel frameshift mutation in the lipoprotein lipase gene is rescued by alternative messenger RNA splicing.
    J Clin Lipidol 2017 Mar - Apr;11(2):357-361. Epub 2017 Feb 3.
    LabPlus, Auckland City Hospital, Auckland, New Zealand.
    Background: Type I hyperlipoproteinemia, manifesting as chylomicronemia and severe hypertriglyceridemia, is a rare autosomal recessive disorder usually caused by mutations in the lipoprotein lipase gene (LPL).

    Objective: We sought to determine whether mutations in LPL could explain the clinical indications of a patient presenting with pancreatitis and hypertriglyceridemia.

    Methods: Coding regions of LPL were amplified by polymerase chain reaction and analyzed by nucleotide sequencing. Read More

    Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
    J Pediatr 2017 May 9. Epub 2017 May 9.
    University of Iowa Carver College of Medicine, Stead Family Department of Pediatrics, Iowa City, IA. Electronic address:
    Objectives: To assess whether the age of onset was associated with unique features or disease course in pediatric acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).

    Study Design: Demographic and clinical information on children with ARP or CP was collected at INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE) centers. The Cochran-Armitage trend test and Jonckheere-Terpstra test were used to examine for differences between pediatric age groups (<6, 6-11, and ≥12 years). Read More

    LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects.
    Korean J Intern Med 2017 May 16. Epub 2017 May 16.
    Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
    Background/aims: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community.

    Methods: A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models. Read More

    Update on APOA5 Genetics: Toward a Better Understanding of Its Physiological Impact.
    Curr Atheroscler Rep 2017 Jul;19(7):30
    Unitat de Recerca en Lípids i Arteriosclerosi, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Sant Llorenç 21, 43201, Reus, Spain.
    Purpose Of Review: This review is intended to summarize the genetic studies published during the last 3 years that help us understand the physiology of apoAV and its clinical implications.

    Recent Findings: APOA5 is probably the gene with the strongest effect on triglyceride (TG) metabolism. APOA5 is almost exclusively expressed in the liver, and its product apoAV has a very low circulating concentration. Read More

    Fructose increases corticosterone production in association with NADPH metabolism alterations in rat epididymal white adipose tissue.
    J Nutr Biochem 2017 Apr 6;46:109-116. Epub 2017 Apr 6.
    Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Farmacología, Cátedra de Farmacología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Cardiológicas (ININCA), Buenos Aires, Argentina. Electronic address:
    Metabolic syndrome is an array of closely metabolic disorders that includes glucose intolerance/insulin resistance, central obesity, dyslipidemia, and hypertension. Fructose, a highly lipogenic sugar, has profound metabolic effects in adipose tissue, and has been associated with the etiopathology of many components of the metabolic syndrome. In adipocytes, the enzyme 11 β-HSD1 amplifies local glucocorticoid production, being a key player in the pathogenesis of central obesity and metabolic syndrome. Read More

    Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels.
    J Stroke Cerebrovasc Dis 2017 May 8. Epub 2017 May 8.
    Department of Neurosurgery, Mie University Graduate School of Medicine, Mie University Hospital, Mie, Japan. Electronic address:
    Background: Dyslipidemia is a well-known risk factor for carotid stenosis progression, but triglycerides have attracted little attention. The aim of this study was to assess if serum triglycerides affect progression of carotid stenosis in patients with well-controlled low-density lipoprotein cholesterol (LDL-C) levels.

    Methods: This is a retrospective study in a single hospital consisting of 71 Japanese patients with internal carotid artery stenosis greater than or equal to 50% and normal serum LDL-C levels who underwent angiographic examination with or without the resultant carotid artery stenting or endarterectomy from 2007 to 2011, and were subsequently followed up for 4 years. Read More

    Hemophagocytic lymphohistiocytosis in acute African swine fever clinic.
    Vet Immunol Immunopathol 2017 May 8;187:64-68. Epub 2017 Apr 8.
    Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 0014 Yerevan, Armenia.
    Introduction: Hemophagocytic lymphohistiocytosis (HLH) usually has been defined as the combination of a proliferation of cytologically benign, actively phagocytic macrophages in bone marrow, spleen, lymph nodes, etc. in association with fever, cytopenia, splenomegaly, and hypertriglyceridemia. HLH is often triggered by viral infection. Read More

    Prevalence of metabolic syndrome and its association with lifestyle and cardiovascular biomarkers among postmenopausal women in western Algeria.
    Int J Gynaecol Obstet 2017 May 11. Epub 2017 May 11.
    Département de Biologie, Université d'Oran1 Ahmed Benbella, Oran, Algeria.
    Objective: To evaluate the prevalence of metabolic syndrome (MetS), its components, and their relationship with lifestyle, inflammation, and oxidative stress among postmenopausal Algerian women.

    Methods: A prospective cross-sectional survey was conducted among postmenopausal women at a clinic in Oran, Algeria, from March 1 to June 28, 2015. A diagnosis of MetS was made using the National Cholesterol Education Program Adult Treatment Panel III guidelines. Read More

    Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors.
    Pediatr Diabetes 2017 May 11. Epub 2017 May 11.
    Department of Paediatrics, Torrecárdenas Hospital, Almería, Spain.
    Background: The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors.

    Materials And Methods: Population-based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9. Read More

    Chronic active Epstein-Barr virus infection associated with hemophagocytic syndrome and extra-nodal natural killer/T-cell lymphoma in an 18-year-old girl: A case report.
    Medicine (Baltimore) 2017 May;96(19):e6845
    Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
    Rationale: Chronic active Epstein-Barr virus infection (CAEBV) associated with hemophagocytic syndrome (HPS) and extra-nodal natural killer (NK)/T-cell lymphoma (ENKL) is a rare life-threatening disorder. This disease is easily misdiagnosed because of its varied presentations.

    Patient Concerns: An 18-year-old girl was admitted to our hospital with a history of edema in the lower limbs and intermittent fever lasting for more than 1 month. Read More

    Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity.
    Clin Toxicol (Phila) 2017 Jul 26;55(6):603-607. Epub 2017 Feb 26.
    a Division of Emergency Medicine , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
    Background: Intravenous lipid emulsion (ILE) has gained favor as a rescue treatment for cardiovascular collapse due to intravenous local anesthetic overdose, however, goals of ILE therapy are still being defined. We describe a case of a girl given 66 mL/kg of 20% lipid emulsion (ILE) in the treatment of presumed mepivacaine toxicity.

    Case Report: An 11-year-old girl weighing 55. Read More

    Prevalence of Canine Obesity, Obesity-Related Metabolic Dysfunction, and Relationship with Owner Obesity in an Obesogenic Region of Spain.
    Front Vet Sci 2017 25;4:59. Epub 2017 Apr 25.
    Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain.
    The main objective of this study was to evaluate the prevalence of canine obesity and obesity-related metabolic dysfunction (ORMD) in the obesogenic area in Spain. The prevalence of overweight/obesity among owners of obese pets was also evaluated. In the sample population studied (93 client-owned dogs), 40. Read More

    Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated.
    Am J Physiol Endocrinol Metab 2017 May 9:ajpendo.00416.2016. Epub 2017 May 9.
    Karolinska Institutet
    Bile acid (BA) production in mice is regulated by hepatic farnesoid X receptors and by intestinal fibroblast growth factor (FGF) 15, (in humans FGF19) a suppressor of BA synthesis that also reduces serum triglycerides and glucose. Cholestyramine treatment reduces FGF19 and induces BA synthesis while plasma triglycerides may increase of unclear reasons. We explored if FGF19 may suppress BA synthesis and plasma triglycerides in humans by modulation of FGF19 levels through long-term cholestyramine at increasing doses. Read More

    Variations in serum free thyroxin concentration within normal ranges predict the incidence of metabolic syndrome in non-obese adults: a Cohort Study.
    Thyroid 2017 May 9. Epub 2017 May 9.
    Univ Med Scs, Endocrine Science Research Center - Taleghani Hosp Shaheed B , Evin Avenue , PO Bos 19395-4763 , Tehran, Iran, Islamic Republic of , 54763 ;
    Background: The association of changes in thyroid hormone values overtime with the incidence of metabolic syndrome (MetS) has not yet been evaluated. This study, for the first time, assessed the effect of thyroid hormone variations in the subclinical and euthyroid range on the incidence of MetS and its components over a 10 year follow-up in an adult population.

    Methods: Data were analyzed from the prospective population-based Tehran Thyroid Study. Read More

    Similar but not the same: Differential diagnosis of HLH and sepsis.
    Crit Rev Oncol Hematol 2017 Jun 23;114:1-12. Epub 2017 Mar 23.
    Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.
    Differential diagnosis of hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) and sepsis is critically important because the life-saving aggressive immunosuppressive treatment, required in the effective HLH therapy, is absent in sepsis guidelines. Moreover, HLH may be complicated by sepsis. Hyperinflammation, present in both states, gives an overlapping clinical picture including fever and performance status deterioration. Read More

    Genetics of Lipodystrophy.
    Endocrinol Metab Clin North Am 2017 Jun 22;46(2):539-554. Epub 2017 Feb 22.
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10-CRC, Room 6-5942, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address:
    Lipodystrophy disorders are characterized by selective loss of fat tissue with metabolic complications including insulin resistance, hypertriglyceridemia, and nonalcoholic liver disease. These complications can be life-threatening, affect quality of life, and result in increased health care costs. Genetic discoveries have been particularly helpful in understanding the pathophysiology of these diseases, and have shown that mutations affect pathways involved in adipocyte differentiation and survival, lipid droplet formation, and lipid synthesis. Read More

    Geography of Food Consumption Patterns between South and North China.
    Foods 2017 May 5;6(5). Epub 2017 May 5.
    Department of Nutritional Science and Food Management, Ewha Womans University, Daehyun-dong, Sodaemun-gu, Seoul 03760, Korea.
    The geographical environment, food culture, and dietary habits are substantially different between the southern and northern regions in China. We investigated the associations with dietary patterns and metabolic syndrome between Chinese adult from the southern and northern regions (North: 1249; South: 1849) using data from the Chinese Health and Nutrition 2009 survey. Respectively, four dietary patterns were identified by factor analysis in each of the two regions. Read More

    Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR(-/-) and LDLR(+/+) mice.
    Immun Inflamm Dis 2017 Jun 13;5(2):151-162. Epub 2017 Mar 13.
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
    Introduction: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D3 , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.

    Methods: We analyzed female LDLR(-/-) and LDLR(+/+) mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation. Read More

    Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies.
    Oncotarget 2017 Apr 27. Epub 2017 Apr 27.
    Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
    We have performed exome-wide association studies to identify single nucleotide polymorphisms that influence serum concentrations of triglycerides, high density lipoprotein (HDL)-cholesterol, or low density lipoprotein (LDL)-cholesterol or confer susceptibility to hypertriglyceridemia, hypo-HDL-cholesterolemia, or hyper-LDL-cholesterolemia in Japanese. Exome-wide association studies for serum triglycerides (13,414 subjects), HDL-cholesterol (14,119 subjects), LDL-cholesterol (13,577 subjects), hypertriglyceridemia (4742 cases, 8672 controls), hypo-HDL-cholesterolemia (2646 cases, 11,473 controls), and hyper-LDL-cholesterolemia (4489 cases, 9088 controls) were performed with HumanExome-12 DNA Analysis BeadChip or Infinium Exome-24 BeadChip arrays. Twenty-four, 69, or 32 loci were significantly (P < 1. Read More

    Nonoverweight nonalcoholic fatty liver disease and incident cardiovascular disease: A post hoc analysis of a cohort study.
    Medicine (Baltimore) 2017 May;96(18):e6712
    aDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science bDepartment of Diabetology, Kameoka Municipal Hospital, Kyoto cDepartment of Gastroenterology, Murakami Memorial Hospital, Asahi University, Gifu, Japan.
    Nonalcoholic fatty liver disease (NAFLD) is known as a risk of incident cardiovascular disease (CVD). About 20% of NAFLD occurs in nonobese individuals. However, it remains to be elucidated the association between nonoverweight with NAFLD and a risk of incident CVD. Read More

    Resistant starch suppresses postprandial hypertriglyceridemia in rats.
    Food Res Int 2016 Nov 15;89(Pt 1):838-842. Epub 2016 Oct 15.
    Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address:
    Postprandial increase in blood triglyceride levels is an independent risk factor for coronary artery disease, and dietary resistant starch (RS) is increasingly being considered for its contribution to disease prevention. Specifically, RS has beneficial effects on of the glycemic index, diabetes, cholesterol levels, and weight management. However, the effects of once-daily intake of RS on postprandial hypertriglyceridemia remain poorly characterized. Read More

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