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    14415 results match your criteria Hypertriglyceridemia

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    Impact on Dyslipidemia After Laparoscopic Sleeve Gastrectomy.
    Obes Surg 2018 Jun 16. Epub 2018 Jun 16.
    General Surgery Department, Bariatric Surgery Program, Hospital Privado Universitario de Córdoba, Naciones Unidas 346, 5016, Córdoba, Argentina.
    Background: Improvement of dyslipidemia is an important benefit of bariatric surgery. The benefits of laparoscopic sleeve gastrectomy (LSG) among dyslipidemia are still a matter of debate.

    Methods: We conducted a retrospective descriptive study between 2010 and 2013. Read More

    Hormonal Management for Transfeminine Individuals.
    Clin Plast Surg 2018 Jul;45(3):313-317
    Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle NE-WMRB 1301, Atlanta, GA 30322, USA.
    Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Read More

    Identifying suspected familial chylomicronemia syndrome.
    Proc (Bayl Univ Med Cent) 2018 Jul 21;31(3):284-288. Epub 2018 May 21.
    Baylor Heart and Vascular Institute, Dallas, Texas.
    Familial chylomicronemia syndrome (FCS) is a rare lipid disorder posing significant clinical burdens on patients. Due to its rarity, variety of presentations, and lack of universal diagnostic criteria, patients see an average of five physicians before diagnosis. We screened adults for a triglyceride level ≥1000 mg/dL from September 2015 to September 2016 and a history of pancreatitis and performed a thorough chart review on those who met the criteria. Read More

    Hypertriglyceridemia thalassemia syndrome.
    J Pediatr Endocrinol Metab 2018 Jun 14. Epub 2018 Jun 14.
    Department of Pathology, King George's Medical University, Lucknow, India.
    Background: Hypertriglyceridemia thalassemia syndrome is a rare entity with an unknown pathogenetic link.

    Case Presentation: We report a case of an 8-month-old female with thalassemia major and increased triglyceride (TG) levels. The clinical features were as in classical thalassemia except for a white discoloration of the plasma. Read More

    The Prevalence of Metabolic Syndrome in Iran: A Systematic Review and Meta-analysis.
    Iran J Public Health 2018 Apr;47(4):473-480
    Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
    Background: Metabolic syndrome (MS) is a collection of metabolic disorders which leads to early cardiovascular disease and diabetes type II. Regarding the wide range of its prevalence in Iran, this systematic review and meta-analysis determined the overall prevalence of the metabolic syndrome in Iran.

    Methods: In this systematic review and meta-analysis, the Medline, ISI, IranMedex, and SID were searched using "metabolic syndrome", "syndrome X", "prevalence", and "Iran" keywords from 2002 to 2012. Read More

    Infection-associated Hemophagocytic Lymphohistiocytosis: An Unusual Clinical Masquerader.
    Cureus 2018 Apr 12;10(4):e2472. Epub 2018 Apr 12.
    Medical Student, Civil Hospital Karachi, Dow University of Health Sciences (DUHS), Karachi, PAK.
    Hemophagocytic lymphohistiocytosis (HLH) secondary to an infection is a great impersonator. It is caused by hyperimmune activation, which leads to a wide array of hematological abnormalities. If the disease is untreated, it is usually fatal. Read More

    A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.
    Proc Natl Acad Sci U S A 2018 Jun 13. Epub 2018 Jun 13.
    Finsen Laboratory, Rigshospitalet, DK-2200 Copenhagen N, Denmark;
    The intravascular processing of triglyceride-rich lipoproteins depends on lipoprotein lipase (LPL) and GPIHBP1, a membrane protein of endothelial cells that binds LPL within the subendothelial spaces and shuttles it to the capillary lumen. In the absence of GPIHBP1, LPL remains mislocalized within the subendothelial spaces, causing severe hypertriglyceridemia (chylomicronemia). The N-terminal domain of GPIHBP1, an intrinsically disordered region (IDR) rich in acidic residues, is important for stabilizing LPL's catalytic domain against spontaneous and ANGPTL4-catalyzed unfolding. Read More

    [Relationship between GSTM1 and GSTT1 gene polymorphisms and plasma lipid and apolipoprotein levels in Chinese normalipidemic and endogenous hypertriglyceridemic subjects].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Jun;35(3):408-413
    Laboratory of Genetic Disease and Perinatal Medicine, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
    Objective: To investigate effects of GSTM1 and GSTT1 gene polymorphisms on serum lipid and apopoprotein levels in healthy normolipidemic and endogenous hypertriglyceridemic subjects.

    Methods: Two hundred and thirty-seven healthy normolipidemic and 102 endogenous hypertriglyceridemic subjects from a population of Chinese Han nationality in Chengdu area were studied using the multiplex polymerase chain reaction (PCR). Serum lipids were measured by enzymatic kits and apolipoproteins AⅠ, AⅡ, B100, CⅡ, CⅢ and E were measured by the RID kits. Read More

    IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is related to triglyceride level in diet-induced obese rats.
    BMC Endocr Disord 2018 Jun 13;18(1):39. Epub 2018 Jun 13.
    Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710061, People's Republic of China.
    Background: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia. Read More

    Phase I safety and pharmacokinetic study of cipatinib, an original dual tyrosine kinase inhibitor.
    Thorac Cancer 2018 Jun 12. Epub 2018 Jun 12.
    Department of Medical Oncology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: Cipatinib is a novel tyrosine kinase inhibitor against both EGFR and HER2/neu. This phase I trial was conducted to assess the safety, dose-limiting toxicities (DLTs), and maximum-tolerated dose of cipatinib in HER2-positive patients with advanced breast cancer.

    Methods: Eligible adults with advanced breast cancer were administered cipatinib 200 mg/day (n = 3) as an initial dose, with escalating dosages of 400 mg (n = 4), 800 mg (n = 2), 1200 mg (n = 3), 1400 mg (n = 3), 1600 mg (n = 3), and 1800 mg (n = 2) in 21 day cycles. Read More

    The effect of volanesorsen treatment on the burden associated with familial chylomicronemia syndrome: the results of the ReFOCUS Study.
    Expert Rev Cardiovasc Ther 2018 Jun 11. Epub 2018 Jun 11.
    b Akcea Therapeutics , Cambridge , MA , USA.
    Background: Volanesorsen, an investigational inhibitor of apoC-III synthesis, significantly reduced triglyceride levels in clinical trials in patients with familial chylomicronemia syndrome (FCS), a rare genetic disorder characterized by marked chylomicronemia leading to a spectrum of symptoms, including recurrent abdominal pain and episodes of potentially fatal acute pancreatitis (AP).

    Objective: To determine the effect of volanesorsen on burden of disease on patients with FCS Methods: ReFOCUS was a retrospective global web-based survey open to patients with FCS who received volanesorsen for ≥3 months in an open-label extension study. The survey included questions about patients' experiences before and after volanesorsen treatment. Read More

    Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.
    J Assist Reprod Genet 2018 Jun 7. Epub 2018 Jun 7.
    CS Mott Center for Human Growth and Development, Department of Ob/Gyn, Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 275 East Hancock, Detroit, MI, 48201, USA.
    Here we examine recent evidence suggesting that many drugs and diet supplements (DS), experimental AMP-activated protein kinase (AMPK) agonists as well as energy-depleting stress, lead to decreases in anabolism, growth or proliferation, and potency of cultured oocytes, embryos, and stem cells in an AMPK-dependent manner. Surprising data for DS and drugs that have some activity as AMPK agonists in in vitro experiments show possible toxicity. This needs to be balanced against a preponderance of evidence in vivo that these drugs and DS are beneficial for reproduction. Read More

    Dilated cardiomyopathy secondary to acute pancreatitis caused by hypertriglyceridemia.
    J Surg Case Rep 2018 May 18;2018(5):rjy104. Epub 2018 May 18.
    Department of Surgery, Division of Acute Care Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    A 30-year-old male presented to an outside facility with acute pancreatitis and triglycerides of 1594. He was transferred to our facility after becoming febrile, hypoxic and in acute renal failure with triglycerides of 4243. CT scan performed showed wall-off pancreatic necrosis. Read More

    Establishing the role of in protein-losing enteropathy: a homozygous missense variant leads to an attenuated phenotype.
    J Med Genet 2018 Jun 6. Epub 2018 Jun 6.
    The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.
    Background: Intestinal integrity is essential for proper nutrient absorption and tissue homeostasis, with damage leading to enteric protein loss, that is, protein-losing enteropathy (PLE). Recently, homozygous nonsense variants in the plasmalemma vesicle-associated protein gene () were reported in two patients with severe congenital PLE. PLVAP is the building block of endothelial cell (EC) fenestral diaphragms; its importance in barrier function is supported by mouse models of Plvap deficiency. Read More

    Hemophagocytic lymphohistiocytosis with immunotherapy: brief review and case report.
    J Immunother Cancer 2018 Jun 5;6(1):49. Epub 2018 Jun 5.
    Inova Center for Personalized Health, Inova Schar Cancer Institute, 8505 Arlington Blvd Suite 140, Fairfax, VA, 22031, USA.
    Background: Hemophagocytic Lymphohistiocytosis (HLH), a rare but potentially fatal syndrome of immune hyperactivation, may be an under-recognized immune-related adverse event (irAE). Unlike other irAEs, HLH triggered by immune checkpoint blockade is not well described; no particular diagnostic guidelines and treatment regimens exist. The HLH-2004 criteria remain as the common diagnostic guide. Read More

    Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation.
    Front Cell Infect Microbiol 2018 9;8:147. Epub 2018 May 9.
    School of Life Sciences, University of Hyderabad, Hyderabad, India.
    Deficiency of leptin () and/or desensitization of leptin signaling () and elevated expression of suppressor of cytokine signaling-3 (SOCS3) reported in obesity are also reported in a variety of pathologies including hypertriglyceridemia, insulin resistance, and malnutrition as the risk factors in host defense system. Viral infections cause the elevated SOCS3 expression, which inhibits leptin signaling. It results in immunosuppression by T-regulatory cells (Tregs). Read More

    Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE.
    J Clin Gastroenterol 2018 Jun 2. Epub 2018 Jun 2.
    Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, Iowa City, IA.
    Introduction: The significance of pancreas divisum (PD) as a risk factor for pancreatitis is controversial. We analyzed the characteristics of children with PD associated with acute recurrent or chronic pancreatitis to better understand its impact.

    Patients And Methods: We compared children with or without PD in the well-phenotyped INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort. Read More

    Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control.
    J Diabetes Complications 2018 May 12. Epub 2018 May 12.
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia; Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science, The University of Queensland, Brisbane, Australia. Electronic address:
    Aims: To examine the relationship between steatosis quantified by controlled attenuation parameter (CAP) values and glycaemic/metabolic control.

    Methods: 230 patients, recruited from an Endocrine clinic or primary care underwent routine Hepatology assessment, with liver stiffness measurements and simultaneous CAP. Multivariable logistic regression was performed to identify potential predictors of Metabolic Syndrome (MetS), HbA1c ≥ 7%, use of insulin, hypertriglyceridaemia and CAP ≥ 300 dB/m. Read More

    Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr mice.
    Atherosclerosis 2018 May 24;275:43-49. Epub 2018 May 24.
    Edward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University, Saint Louis, MO, 63104, USA; Center for Cardiovascular Research, Saint Louis, MO, 63104, USA; Liver Center, Saint Louis University, Saint Louis, MO, 63104, USA. Electronic address:
    Background And Aims: Obesity, hepatosteatosis, and hypertriglyceridemia are components of the metabolic syndrome and independent risk factors for cardiovascular disease. The lipid droplet-associated protein CIDEC (cell death-inducing DFFA-like effector C), known in mice as FSP27 (fat-specific protein 27), plays a key role in maintaining triacylglyceride (TAG) homeostasis in adipose tissue and liver, and controls circulating TAG levels in mice. Importantly, mutations and SNPs in CIDEC are associated with dyslipidemia and altered metabolic function in humans. Read More

    Relationship of lipid regulatory gene polymorphisms and dyslipidemia in a pediatric population: the CASPIAN III study.
    Hormones (Athens) 2018 Mar 17;17(1):97-105. Epub 2018 Apr 17.
    Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Hezar-Jarib Ave, Isfahan, Iran.
    Objective: In this study, we aimed to assess the association between four variants in three genes whose association has been reported in adults but not in children. We evaluated the relationship of the GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) polymorphisms with serum lipid levels in Iranian children.

    Design: This cross-sectional study was conducted in a subpopulation of the CASPIAN III study. Read More

    Effect of infliximab and tocilizumab on fructose-induced hyperinsulinemia and hypertension in rats.
    Biomed Pharmacother 2018 May 29;105:182-186. Epub 2018 May 29.
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
    Fructose administration can induce hypertension, insulin resistance and hypertriglyceridemia. Here, we investigated the possible protective effect of infliximab (IFX), a tumor necrosis factor alpha (TNF-α) inhibitor, or tocilizumab (TOC), an interleukin-6 (IL6) inhibitor, on fructose-induced increase in blood pressure, insulin resistance and hyperlipidemia in rats. The animals were fed a 60% fructose diet in the absence or presence of IFX (5 mg/kg, i. Read More

    [Eruptive Xanthomas: A Cardinal Manifestation of Serious Metabolic Disease].
    Acta Med Port 2018 Apr 30;31(4):219-222. Epub 2018 Apr 30.
    Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra, Portugal.
    Eruptive cutaneous xanthomas develop as a result of rapid intracellular and dermal deposition of lipids and are a cardinal sign of high cardiovascular risk. We describe the case of a 47-year-old male with multiple dome-shaped, yellowish and firm, slightly pruriginous papules distributed over the buttocks, lumbar region, abdominal wall, elbows and neck, for about two months. Previous medical history included alcohol abuse, non-medicated type 2 diabetes mellitus, dyslipidemia and recent onset of therapy with olanzapine for depressive syndrome. Read More

    Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice.
    J Dev Orig Health Dis 2018 Jun 1:1-8. Epub 2018 Jun 1.
    1Laboratory of Experimental Physiology,Department of Physiological Sciences,Federal University of Maranhão,São Luís,MA,Brazil.
    Monosodium l-glutamate (MSG)-induced obesity is a useful model for non-alcoholic fatty liver disease (NAFLD) studies. However, there is limited data on its initiation and progression. Thus, this study aimed to characterize the onset of metabolic and histopathological features of NAFLD and its progression to non-alcoholic steatohepatitis (NASH) in this model. Read More

    Undernutrition in childhood resulted in bad dietary behaviors and the increased risk of hypertension in a middle-aged Chinese population.
    J Dev Orig Health Dis 2018 Jun 1:1-8. Epub 2018 Jun 1.
    1School of Public Health,Anhui Medical University,Hefei,Anhui,P. R. China.
    This study was designed to explore the association between undernutrition in the growth period and cardiovascular risk factors in a middle-aged Chinese population. A total of 1756 subjects, aged 45-60 years, were invited to participate in the Hefei Nutrition and Health Study and divided into three groups according to their self-reported animal food intake in the growth period. Group 1, Group 2 and Group 3 were defined as undernutrition, nutritional improvement and the good nutrition group, respectively. Read More

    Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children.
    Can J Gastroenterol Hepatol 2018 26;2018:9465784. Epub 2018 Apr 26.
    School of Medicine in Katowice, Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland.
    Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in obese children. Early diagnosis and treatment are essential for curing or slowing down the disease progression. The aim of the study was to assess the prevalence of NAFLD in this population and to identify anthropometrical and metabolic risk factors for NAFLD prediction and its development. Read More

    Metabolic Syndrome Among Antiretroviral Therapy-Naive Versus Experienced HIV-Infected Patients Without Preexisting Cardiometabolic Disorders in Western Kenya.
    AIDS Patient Care STDS 2018 Jun;32(6):215-222
    8 Department of Medicine, Duke Clinical Research Institute and Duke Global Health Institute, Duke University , Durham, North Carolina.
    Metabolic syndrome (MetS), a cluster of cardiovascular disease risk factors, is increasingly common in people living with HIV; however, data on prevalence and the role of antiretroviral therapy (ART) as a risk factor for MetS in sub-Saharan Africa are lacking. We conducted a cross-sectional study to assess the prevalence and risk factors for MetS among ART-naive and ART-experienced HIV-infected adults without preexisting cardiometabolic disorders in Western Kenya using validated questionnaires and laboratory tests after overnight fasting. We used logistic regression to identify associations between traditional risk factors, HIV disease characteristics, ART, and MetS. Read More

    Hypertriglyceridemia in Diabetes Mellitus: Implications for Pediatric Care.
    J Endocr Soc 2018 Jun 1;2(6):497-512. Epub 2018 May 1.
    Boston Children's Hospital, Department of Cardiology, Boston, Massachusetts.
    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). It is estimated that the risk of CVD in diabetes mellitus (DM) is 2 to 10 times higher than in the general population. Much of this increased risk is thought to be related to the development of an atherogenic lipid profile, in which hypertriglyceridemia is an essential component. Read More

    Discovering Associations of Adverse Events with Pharmacotherapy in Patients with Non-Small Cell Lung Cancer Using Modified Apriori Algorithm.
    Biomed Res Int 2018 23;2018:1245616. Epub 2018 Apr 23.
    Department of Pharmacy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Aim: To explore the associations between adverse events and pharmacotherapy in patients with non-small cell lung cancer.

    Methods: 16,527 patients with non-small cell lung cancer admitted to the Cancer Hospital, Chinese Academy of Medical Sciences, between January 1, 2010, and December 31, 2016, were included in the study. Their medication and laboratory examinations data were extracted from the medical records. Read More

    First case report of acquired generalized lipodystrophy associated with common variable immunodeficiency.
    J Clin Endocrinol Metab 2018 May 28. Epub 2018 May 28.
    Department of Endocrinology and Metabolism, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Context: Acquired generalized lipodystrophy (AGL), a rare disorder characterized by loss of subcutaneous adipose tissue, is estimated to occur in association with autoimmune diseases in approximately 25% of the cases. Common variable immunodeficiency (CVI) is a condition known for its strong association with autoimmune diseases often occurring with negative autoantibodies. We describe here the first known case of AGL in a patient with CVI. Read More

    Essential Fatty Acid Status in Surgical Infants Receiving Parenteral Nutrition With a Composite Lipid Emulsion: A Case Series.
    JPEN J Parenter Enteral Nutr 2018 May 30. Epub 2018 May 30.
    Harvard Medical School, Boston, Massachusetts, USA.
    Infants requiring prolonged parenteral nutrition (PN) may receive intravenous (IV) lipid in the form of soybean oil, fish oil, or a composite lipid emulsion (CLE) (i.e., SMOFlipid®). Read More

    Successful exchange transfusion in extremely preterm infant after symptomatic lipid overdose.
    J Neonatal Perinatal Med 2018 May 23. Epub 2018 May 23.
    Department of Neonatology, Hospital Clínico San Carlos Madrid, Spain.
    Background: Complications of intravenous lipid administration are relatively uncommon. However, inadvertent rapid infusion of intravenous fat emulsion (IVFE) is an inherent risk when fats are infused separately from the dextrose-amino acid solution.

    Case Report: Extremely preterm infant, born at 25 weeks and 6 days of gestational age weighing 920 g, who inadvertently received a massive overdose of IVFE due to a device failure. Read More

    Pharmacological treatment options for severe hypertriglyceridemia and familial chylomicronemia syndrome.
    Expert Rev Clin Pharmacol 2018 Jun 11:1-10. Epub 2018 Jun 11.
    c Department of Metabolic Medicine/Chemical Pathology , Guy's and St Thomas' Hospitals , London , UK.
    Introduction: A spectrum of disorders, ranging from rare severe cases of homozygous null lipoprotein lipase deficiency (LPLD)-familial chylomicronemia syndrome (FCS) to heterozygous missense LPLD or polygenic causes, result in hypertriglyceridemia and pancreatitis. The effects of mutations are exacerbated by environmental factors such as diet, pregnancy, and insulin resistance. Areas covered: In this review, authors discuss chronic treatment of FCS by ultra-low fat diets allied with the use of fibrates, omega-3 fatty acids, niacin, statins, and insulin-sensitizing therapies depending on the extent of residual lipoprotein lipase (LPL) activity; novel therapies in development target triglyceride (TG)-rich lipoprotein particle clearance. Read More

    Bexarotene-Induced Hypertriglyceridemia: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):234-238. Epub 2018 Apr 11.
    Oncology Clinic, UMass Memorial Medical Center, Worcester, Massachusetts, USA.
    We present a case of a patient with cutaneous T-cell lymphoma started on bexarotene 300 mg/m due to progressing disease. The patient experienced good clinical response, but unfortunately, she developed rapid and profound hypertriglyceridemia. Although hypertriglyceridemia occurs in high incidence with bexarotene therapy, management recommendations are scarce. Read More

    Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span.
    J Clin Lipidol 2018 Apr 27. Epub 2018 Apr 27.
    FCS Foundation, San Diego, CA, USA.
    Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder with loss of function mutations of lipoprotein lipase resulting in hypertriglyceridemia and accumulation of chylomicrons in plasma, often leading to acute pancreatitis. The mainstay of treatment is a specialized very-low-fat diet. Even adhering to the diet, some patients may experience high triglycerides and pancreatitis. Read More

    Initial Characteristics and Clinical Severity of Hemophagocytic Lymphohistiocytosis in Pediatric Patients Admitted in the Emergency Department.
    Pediatr Emerg Care 2018 May 23. Epub 2018 May 23.
    From the Departments of Pediatrics, and.
    Objectives: The diagnosis and management of children with hemophagocytic lymphohistiocytosis (HLH) admitted in the emergency department (ED) are challenging. The present study aimed at describing the initial characteristics of pediatric patients with HLH upon admission in the ED. Moreover, the clinical severity of the condition was assessed. Read More

    The Effects of Long-Term Dietary Therapy on Patients with Hypertriglyceridemia.
    J Atheroscler Thromb 2018 May 22. Epub 2018 May 22.
    Laboratory of Clinical Nutrition and Management, School of Food and Nutritional Sciences, The University of Shizuoka.
    Aim: This study aimed to evaluate the effect of diet on serum lipids and to assess the effectiveness of long-term dietary therapy for hypertriglyceridemia.

    Methods: Seventy-nine patients (34 males and 45 females) with hypertriglyceridemia were enrolled and underwent dietary counseling for 12 months based on the following three recommendations: (1) reduce carbohydrate intake, (2) increase n-3 polyunsaturated fatty acid (PUFA) intake, and (3) limit alcohol drinking. We examined the effect of dietary therapy for 6 months on serum triglyceride (TG) levels and also compared the effectiveness of dietary and combined drug therapies on preventing arteriosclerotic disease from 7 to 12 months. Read More

    Oral Magnesium Supplementation and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
    Adv Chronic Kidney Dis 2018 May;25(3):261-266
    Biomedical Research Unit of the Mexican Social Security Institute, Durango, Durango, Mexico; and Research Group on Diabetes and Chronic Illnesses, Durango, Durango, Mexico. Electronic address:
    The objective of the study was to evaluate the efficacy of oral magnesium supplementation in the improvement of metabolic syndrome (MetS) and its components. This is a randomized double-blind, placebo-controlled clinical trial that enrolled 198 individuals with MetS and hypomagnesemia who were randomly allocated to receive either 30 mL of magnesium chloride 5% solution, equivalent to 382 mg of elemental magnesium (n = 100), or placebo solution (n = 98), daily for 16 weeks. Serum magnesium levels <1. Read More

    Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
    Hepatology 2018 May 23. Epub 2018 May 23.
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520.
    Pharmacologic inhibition of acetyl-CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for non-alcoholic fatty liver disease (NAFLD) via simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid oxidation. However, the effects of ACC inhibition on hepatic mitochondrial oxidation, anaplerosis, and ketogenesis in vivo are unknown. Here, we evaluated the impact of a novel liver-directed allosteric inhibitor of ACC1 and ACC2 (Compound 1) on these parameters, as well as glucose and lipid metabolism, in control and diet-induced rodent models of NAFLD. Read More

    Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.
    Mol Metab 2018 May 16. Epub 2018 May 16.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, United Kingdom. Electronic address:
    Objective: Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The 'overflow hypothesis' posits that the capacity to increase the size and number of adipocytes is finite and that when this limit is exceeded, fat accumulates in ectopic sites and leads to metabolic disease. Read More

    Severe hypertriglyceridemia. Clinical characteristics and therapeutic management.
    Clin Investig Arterioscler 2018 May 19. Epub 2018 May 19.
    Servicio de Cardiología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
    Introduction: The therapeutic management of severe hypertriglyceridaemia represents a clinical challenge.

    Objectives: The objectives of this study were 1) to identify the clinical characteristics of patients with severe hypertriglyceridaemia, and 2) to analyse the treatment established by the physicians in each case.

    Methods: A cross-sectional study was carried out using the computerised medical records of all patients>18 years of age with a blood triglyceride level≥1,000mg/dL between 1 January 2011 and 31 December 2016. Read More

    The Correlation of Dyslipidemia with the Extent of Coronary Artery Disease in the Multiethnic Study of Atherosclerosis.
    J Lipids 2018 27;2018:5607349. Epub 2018 Mar 27.
    Harbor UCLA Cardiology, 1000 W. Carson St, Torrance, CA 90509, USA.
    Background: The extent of coronary artery calcium (CAC) improves cardiovascular disease (CVD) risk prediction. The association between common dyslipidemias (combined hyperlipidemia, simple hypercholesterolemia, metabolic Syndrome (MetS), isolated low high-density lipoprotein cholesterol, and isolated hypertriglyceridemia) compared with normolipidemia and the risk of multivessel CAC is underinvestigated.

    Objectives: To determine whether there is an association between common dyslipidemias compared with normolipidemia, and the extent of coronary artery involvement among MESA participants who were free of clinical cardiovascular disease at baseline. Read More

    Highly efficacious, long-term, triglyceride lowering with rituximab therapy in a patient with autoimmune hypertriglyceridemia.
    J Clin Lipidol 2018 Apr 30. Epub 2018 Apr 30.
    Aix Marseille University, INSERM, INRA, C2VN, Marseille, France; Department of Nutrition, Metabolic Diseases and Endocrinology, APHM, La Conception Hospital, Marseille, France.
    We report the first case of an autoimmune hypertriglyceridemia successfully treated with rituximab, an anti-CD20-targeted monoclonal antibody. A 45-year-old man, with prior autoimmune conditions, developed severe, acquired hypertriglyceridemia resistant to traditional triglyceride lowering therapies. After the elimination of secondary or genetic causes, we detected the presence of anti-LPL-IgG by immunoblot. Read More

    The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study.
    J Clin Lipidol 2018 Apr 26. Epub 2018 Apr 26.
    Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
    Background: Familial chylomicronemia syndrome (FCS) is a rare genetic disorder characterized by a deficiency of lipoprotein lipase leading to extreme hypertriglyceridemia. Patients' burden of illness and quality of life have been poorly addressed in the literature.

    Objective: To understand the ways in which FCS impacts patients' lives. Read More

    [Lipid Blood Profile in Old Patients With Ischemic Heart Disease].
    Kardiologiia 2018 Mar(3):28-36
    Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.
    Purpose: to assess prevalence of dyslipidemia in patients with ischemic heart disease (IHD) older than 75 years as well as to evaluate possible associations between serum lipids and various cardiovascular and other diseases in these patients.

    Methods: We enrolled in this cross sectional study 555 hospitalized IHD patients aged 75-98 years (mean age 86.8 years, 74. Read More

    Acute pancreatitis secondary to oral contraceptive-induced hypertriglyceridemia: a case report.
    Gynecol Endocrinol 2018 May 21:1-3. Epub 2018 May 21.
    a Departamento de Medicina , Universidade Estadual de Ponta Grossa , Ponta Grossa , Brazil.
    Hypertriglyceridemia is the third most common cause of acute pancreatitis. Among the causes that lead to secondary hypertriglyceridemia, the use of contraceptive agents is the main reason to be assessed in young women. We report a case of a 31-year-old woman who had suffered two acute pancreatitis episodes secondary to hypertriglyceridemia. Read More

    The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis.
    Nutr Metab Cardiovasc Dis 2018 Jul 21;28(7):657-674. Epub 2018 Mar 21.
    Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
    Background & Aims: Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. Read More

    Prevalence and risk factors of type 2 diabetes in insomnia sufferers: a study on 1311 individuals referred for sleep examinations.
    Sleep Med 2018 Jun 8;46:37-45. Epub 2018 Mar 8.
    Erasme Hospital, Department of Psychiatry and Sleep Laboratory, Université libre de Bruxelles, ULB, Brussels, Belgium.
    Background: Several studies have investigated the particular relationship between insomnia and type 2 diabetes. However, few studies have investigated the prevalence and risk factors for type 2 diabetes in insomnia sufferers. The aim of this study was to examine the prevalence and risk factors of type 2 diabetes in a large sample of insomnia sufferers. Read More

    Hypertriglyceridemia and Cardiovascular Risk: A cautionary note about metabolic confounding.
    J Lipid Res 2018 May 16. Epub 2018 May 16.
    McGill University, Canada.
    Triglycerides are the conventional tool to measure very low-density lipoproteins (VLDL) whereas low-density lipoprotein cholesterol (LDL-C) is the conventional tool to measure low-density lipoproteins (LDL). Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated cardiovascular risk is related to triglycerides independently of LDL-C and this has led to a series of new therapeutic agents designed specifically to reduce plasma triglycerides. The triglyceride hypothesis posits that increased levels of triglycerides increase cardiovascular risk and decreasing plasma triglycerides decreases cardiovascular risk. Read More

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