14,845 results match your criteria Hypertriglyceridemia


Real-world effectiveness of antipsychotic monotherapy and polytherapy in 1543 patients with acute-phase schizophrenia.

Asian J Psychiatr 2019 Feb 8;40:82-87. Epub 2019 Feb 8.

Department of Psychiatry, Numazu Chuo Hospital, Numazu, Japan.

Purpose: The effectiveness of antipsychotic treatments in the acute phase of schizophrenia in actual clinical practice remains somewhat unclear. Therefore, the purpose of the present naturalistic, multi-center study conducted from 1 year starting in September 2017 was to examine the response rate to an initial or second antipsychotic in newly admitted patients with acute-phase schizophrenia, as well as the response rate and quality of augmentation with two antipsychotics in patients who failed to respond to both the initial and second antipsychotics.

Results: In total, there were 660 (42. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.005DOI Listing
February 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

Chylomicrons: When you can't direct the wind, adjust the sail.

Atherosclerosis 2019 Feb 5. Epub 2019 Feb 5.

Research Institute of the McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.015DOI Listing
February 2019

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment.

Cancer Biol Med 2018 Nov;15(4):443-451

Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy. This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372914PMC
November 2018

Acute Pancreatitis after Colonoscopy: A Case Presentation and Literature Review.

Case Rep Gastrointest Med 2019 15;2019:4587371. Epub 2019 Jan 15.

Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.

We report a case of acute pancreatitis after an elective screening colonoscopy. A 51-year-old male with a left ventricular assist device for end-stage nonischemic cardiomyopathy and a family history of colorectal cancer was admitted for an expedited heart transplant evaluation. He underwent screening colonoscopy during this admission which was technically uncomplicated apart from requiring slight maneuvering at the splenic flexure. Read More

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http://dx.doi.org/10.1155/2019/4587371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350525PMC
January 2019

The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome.

PLoS One 2019 14;14(2):e0212341. Epub 2019 Feb 14.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Spot 14 (S14) protein is primarily expressed in adipogenic tissues. Compared to wild type, S14 knockout mice had better resistance to diet-induced obesity and glucose tolerance. However, the association between serum S14 level and metabolic variables in humans has never been investigated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212341PLOS
February 2019

The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: A 10-year analysis of the National Inpatient Sample.

Medicine (Baltimore) 2019 Feb;98(7):e14378

Gastroenterology and Hepatology Department, Digestive Disease Institute.

The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. Read More

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http://dx.doi.org/10.1097/MD.0000000000014378DOI Listing
February 2019
3 Reads

Associations Between Serum Uric Acid Levels and Cardiometabolic Risk, Renal İnjury in Obese and Overweight Children

J Clin Res Pediatr Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Manisa Celal Bayar University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey

Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children.

Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL). Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0241DOI Listing
February 2019

Plasma Exchange for the Treatment of Transient Extreme Hypertriglyceridemia Associated with Diabetic Ketoacidosis and Acute Pancreatitis.

Eur J Case Rep Intern Med 2018 25;5(5):000853. Epub 2018 May 25.

Alta Intensità Medica, Department of Internal Medicine, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy.

Diabetic ketoacidosis (DKA) can quite frequently present in association with acute pancreatitis (AP) caused by transient severe hypertriglyceridemia (HTG). Here we report the case of a patient presenting with DKA, severe HTG and AP who received urgent plasma exchange for HTG control, and who reached adequate serum triglyceride levels only after appropriate DKA management. The treatment of patients presenting with DKA and coexistent AP associated with severe HTG should focus first on appropriate DKA management. Read More

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http://dx.doi.org/10.12890/2018_000853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346927PMC

Experimental therapies targeting apolipoprotein C-III for the treatment of hyperlipidemia - spotlight on volanesorsen.

Expert Opin Investig Drugs 2019 Feb 12:1-6. Epub 2019 Feb 12.

a First Propedeutic Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, AHEPA Hospital , Thessaloniki , Greece.

Introduction: Despite the substantial reduction in cardiovascular morbidity and mortality after the management of dyslipidemia with statins, residual risk remains even after achieving low-density lipoprotein cholesterol targets. This residual risk appears to be partly attributed to low levels of high-density lipoprotein cholesterol (HDL-C) and high levels of triglycerides (TG). Apolipoprotein C3 (APOC3) is a key regulator of TG metabolism and its targeting may reduce TG levels and cardiovascular risk. Read More

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http://dx.doi.org/10.1080/13543784.2019.1582028DOI Listing
February 2019

Metreleptin treatment for congenital generalized lipodystrophy type 4 (CGL4): a case report.

Clin Pediatr Endocrinol 2019 31;28(1):1-7. Epub 2019 Jan 31.

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Congenital generalized lipodystrophy type 4 (CGL4) is a rare disease caused by mutations in the gene polymerase I and transcript release factor (), the main symptoms of which are systemic reductions in adipose tissue and muscular dystrophy. The strategy of treating CGL4 is to improve the insulin resistance and hypertriglyceridemia that result from systemic reductions in adipose tissue. Metreleptin, a synthetic analog of human leptin, is effective against generalized lipodystrophies; however, there are no reports of the use of metreleptin in the treatment of CGL4. Read More

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http://dx.doi.org/10.1297/cpe.28.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356095PMC
January 2019
1 Read

[The association between blood lipids and calcaneus bone mineral density in children and adolescents aged 6-16 years in Beijing].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):196-201

Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the association between blood lipid and calcaneus bone mineral density (BMD) in children and adolescents aged 6-16 years in Beijing. Children and adolescents were selected in 30 schools (8 primary schools, 21 middle schools and one 12-year education school) from Dongcheng, Tongzhou, Fangshan and Miyun districts of Beijing by using a stratified cluster sampling method from November 2017 to January 2018. A total of 14 303 students in grade 1 to 4 of primary school, grade 1 of junior and senior middle school were enrolled after excluding subjects who were not able to participate into this study due to trauma or other uncomfortable physical conditions or with missing key values or with diabetes and kidney diseases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.014DOI Listing
February 2019
2 Reads

Resolving the Paradox of Hepatic Insulin Resistance.

Cell Mol Gastroenterol Hepatol 2018 Nov 3;7(2):447-456. Epub 2018 Nov 3.

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Insulin resistance is associated with numerous metabolic disorders, such as obesity and type II diabetes, that currently plague our society. Although insulin normally promotes anabolic metabolism in the liver by increasing glucose consumption and lipid synthesis, insulin-resistant individuals fail to inhibit hepatic glucose production and paradoxically have increased liver lipid synthesis, leading to hyperglycemia and hypertriglyceridemia. Here, we detail the intrahepatic and extrahepatic pathways mediating insulin's control of glucose and lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.016DOI Listing
November 2018
1 Read

Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell.

J Clin Lab Anal 2019 Feb 8:e22839. Epub 2019 Feb 8.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: We aimed to evaluate the values of neutrophil-to-lymphocyte ratio (NLR) and white blood cell (WBC) in predicting severity of acute pancreatitis (AP) with different etiologies.

Methods: We compared NLR and WBC levels in patients with different etiologies and AP severity. The optimal cutoff value for them to predict severe acute pancreatitis (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Read More

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http://dx.doi.org/10.1002/jcla.22839DOI Listing
February 2019
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Long-Term Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα), in Dyslipidemic Patients with Renal Impairment.

Int J Mol Sci 2019 Feb 6;20(3). Epub 2019 Feb 6.

Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba 260-8670, Japan.

Pemafibrate (K-877) is a novel selective peroxisome proliferator-activated receptor-α modulator (SPPARMα) with a favorable benefit-risk balance. Previous clinical trials of pemafibrate used stringent exclusion criteria related to renal functions. Therefore, we investigated its safety and efficacy in a broader range of patients, including those with chronic kidney disease (CKD). Read More

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http://www.mdpi.com/1422-0067/20/3/706
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http://dx.doi.org/10.3390/ijms20030706DOI Listing
February 2019
2 Reads

Autoimmune-Associated Hemophagocytosis and Myelofibrosis in a Newly Diagnosed Lupus Patient: Case Report and Literature Review.

Case Rep Hematol 2019 9;2019:3879148. Epub 2019 Jan 9.

Section of Hematology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Bone marrow abnormalities in SLE are now becoming increasingly recognized, suggesting that the bone marrow may also be an important site of target organ damage. In this study, we present a rare case of concurrent autoimmune hemophagocytic syndrome and autoimmune myelofibrosis, potentially life-threatening conditions, in a newly diagnosed SLE patient. We report a case of a 30-year-old Filipino woman who presented with a one-year history of fever, constitutional symptoms, exertional dyspnea, joint pains, and alopecia and physical examination findings of fever, facial flushing, cervical lymphadenopathies, and knee joint effusions. Read More

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http://dx.doi.org/10.1155/2019/3879148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343163PMC
January 2019
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CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study.

Sci Rep 2019 Feb 6;9(1):1472. Epub 2019 Feb 6.

IRCCS Don Carlo Gnocchi Foundation Italy, Florence, Italy.

A total of 356 elderly subjects [257F; 88-106 years] were genotyped for three polymorphisms of the CLOCK gene by TaqMan real-time PCR approach, in order to find associations with quality of aging. Subjects homozygous for the minor allele of rs1801260 were less frequently overweight (p = 0.046), had higher fasting glucose levels (p = 0. Read More

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http://dx.doi.org/10.1038/s41598-018-37992-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365537PMC
February 2019

Kaempferia parviflora Ethanol Extract, a Peroxisome Proliferator-Activated Receptor γ Ligand-binding Agonist, Improves Glucose Tolerance and Suppresses Fat Accumulation in Diabetic NSY Mice.

J Food Sci 2019 Feb;84(2):339-348

Faculty of Agriculture, Kagawa Univ., 2393 Ikenobe, Miki, Kita, Kagawa, 761-0795, Japan.

This study assessed the effect of Kaempferia parviflora, also known as black ginger (BG), and its ethanol extract (BGE) on peroxisome proliferator-activated receptor (PPAR) γ agonistic activity, glucose tolerance, fat accumulation, and lipids-induced hypertriglyceridemia in mice. PPARγ ligand-binding capacity in vitro and polymethoxy flavone contents were highly observed in organic solvent extracts. In an animal experiment A, male diabetic Nagoya-Shibata-Yasuda mice were divided into five dietary groups and fed each diet for 8 weeks: AIN-93G diet (low-fat [LF] diet), high-fat (HF) diet, HF diet supplemented with 1% BG, HF diet supplemented with 0. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1750-3841.14
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http://dx.doi.org/10.1111/1750-3841.14437DOI Listing
February 2019
3 Reads

Diabetic Ketoacidosis Revealing a Severe Hypertriglyceridemia and Acute Pancreatitis in Type 1 Diabetes Mellitus.

Case Rep Endocrinol 2019 6;2019:8974619. Epub 2019 Jan 6.

Department of Endocrinology, Diabetes, Metabolic Diseases and Nutrition, Mohammed VI University Hospital, Marrakech, Morocco.

Diabetic ketoacidosis (DKA) is a life-threatening acute metabolic complication occurring in patients with diabetes, especially in patients with type 1 diabetes (T1D), due to an insulin deficiency. Moderate hypertriglyceridemia is commonly observed in DKA but severe hypertriglyceridemia with a triglyceride level exceeding 10g/L is very rarely reported. We report a case of a 14-year-old boy who had type 1 diabetes for 4 years treated with insulin therapy, also having adrenal insufficiency treated with hydrocortisone who presented with ketoacidosis and excruciating abdominal pain. Read More

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http://dx.doi.org/10.1155/2019/8974619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339756PMC
January 2019
2 Reads

Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or apoC3 RNA interference.

J Lipid Res 2019 Feb 5. Epub 2019 Feb 5.

UC Davis, United States;

Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil reduces plasma lipids. Diet-induced dyslipidemia in a rhesus model better approximates the pathophysiology of human metabolic syndrome than rodent models. Read More

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http://dx.doi.org/10.1194/jlr.M089508DOI Listing
February 2019
7 Reads

Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr mice.

Atherosclerosis 2019 Jan 29;282:100-109. Epub 2019 Jan 29.

Institute of Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, China. Electronic address:

Background And Aims: Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in triglyceride hydrolysis, and GPIHBP1 deficiency leads to severe hypertriglyceridemia (HTG). Gpihbp1 knockout (GKO) mice develop mild lesions in the aortic root at the age of 11 months. Herein, we investigated the effect of Gpihbp1 deficiency on atherosclerosis (AS) under diabetic conditions. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.025DOI Listing
January 2019
2 Reads
3.994 Impact Factor

The biochemical and genetic diagnosis of lipid disorders.

Curr Opin Lipidol 2019 Jan 31. Epub 2019 Jan 31.

Eurofins Genomics, Louisville, Kentucky, USA.

Purpose Of Review: To examine recent advances in our knowledge on the diagnosis of lipid disorders.

Recent Findings: Fasting values above the 99th percentile for direct LDL-cholesterol (LDL-C), lipoprotein(a), and triglycerides are greater than 225 mg/dl, greater than 160 mg/dl, and greater than 500 mg/dl (>5.82, >394, and >5. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000590DOI Listing
January 2019
2 Reads

Tomato Powder Modulates NF-B, mTOR, and Nrf2 Pathways during Aging in Healthy Rats.

J Aging Res 2019 2;2019:1643243. Epub 2019 Jan 2.

Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Purpose: In the present study, we aimed to investigate the effects of tomato powder (TP) on glucose and lipid metabolism, as well as oxidative stress and the NF-B, mTOR, and Nrf2 pathways during the aging process in healthy rats.

Methods And Results: Male Wistar rats were randomly assigned to four groups as follows: (i) Control group 1 (=15, 3-week old): rats were fed standard diet for 7 weeks; (ii) TP group 1 (=15, 3-week old): rats were fed standard diet supplemented with TP for 7 weeks; (iii) Control group 2 (=15, 8-week old): rats were fed standard diet for 69 weeks; and (iv) TP group 2 (8-week old): rats were fed standard diet supplemented with TP for 69 weeks. TP supplementation significantly reduced the hyperglycemia, hypertriglyceridemia, and hypercholesterolemia and improved liver function and kidney function in 77-week old rats compared with the control animals ( < 0. Read More

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http://dx.doi.org/10.1155/2019/1643243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334329PMC
January 2019
1 Read

Lipemic uveitis and its etiologies in dogs: 75 cases.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Objective: To describe clinical features of dogs with lipemic uveitis (LU).

Animals Studied: Seventy-five dogs (114 eyes) with LU.

Procedures: Medical records of dogs examined by the Cornell University ophthalmology service with a clinical diagnosis of LU between 2008 and 2017 were analyzed. Read More

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http://dx.doi.org/10.1111/vop.12625DOI Listing
February 2019
1 Read

A haplotype of the phosphodiesterase 4D (PDE4D) gene is associated with myocardial infarction and with cardiometabolic parameters: the GEA study.

EXCLI J 2018 19;17:1182-1190. Epub 2018 Dec 19.

Department of Molecular Biology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.

The phosphodiesterase family is involved in a wide spectrum of diseases, including ischemic stroke. However, few studies have analyzed the relationship between phosphodiesterase 4D (PDE4D) and myocardial infarction (MI). Therefore, the aim of this research was to evaluate the association of the gene polymorphisms with MI, and with cardiometabolic parameters in the Mexican population. Read More

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http://dx.doi.org/10.17179/excli2018-1608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343085PMC
December 2018
1 Read

Population Risk of Ischemic Heart Disease Depending on the Volume of Alcohol Consumption by the Population (ЭССЕ-РФ Study in the Kemerovo Region).

Kardiologiia 2019 Jan 28;59(1):62-68. Epub 2019 Jan 28.

Research Institute for Complex Issues of Cardiovascular Diseases.

Purpose: to assess relationship between the prevalence of cardiovascular risk factors and associated population risk of ischemic heart disease (IHD) alcohol consumption in the Siberian region (Kemerovo Region).

Materials And Methods: This work was carried out within the framework of a multicenter epidemiological study "Epidemiology of CardioVascular Diseases in the regions of the Russian Federation" (ЭССЕ-РФ in the Kemerovo region) in 2013. In the final form, the sample size was 1628 individuals aged 25-64 years. Read More

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http://dx.doi.org/10.18087/cardio.2019.1.10217DOI Listing
January 2019
2 Reads

Juvenile-onset systemic lupus erythematosus with severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody.

Pediatr Int 2019 Jan 31. Epub 2019 Jan 31.

Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

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http://dx.doi.org/10.1111/ped.13736DOI Listing
January 2019
1 Read

Oral Glucose Mobilizes Triglyceride Stores From the Human Intestine.

Cell Mol Gastroenterol Hepatol 2018 Oct 12;7(2):313-337. Epub 2018 Oct 12.

Division of Endocrinology and Metabolism, Departments of Medicine and Physiology, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background & Aims: The small intestine regulates plasma triglyceride (TG) concentration. Within enterocytes, dietary TGs are packaged into chylomicrons (CMs) for secretion or stored temporarily in cytoplasmic lipid droplets (CLDs) until further mobilization. We and others have shown that oral and intravenous glucose enhances CM particle secretion in human beings, however, the mechanisms through which this occurs are incompletely understood. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357697PMC
October 2018

Lipid Abnormalities in Persons Living With HIV Infection.

Can J Cardiol 2018 Nov 15. Epub 2018 Nov 15.

Division of Cardiology, Zuckerberg San Francisco General Hospital, and Department of Medicine, University of California, San Francisco, California, USA.

Lipid abnormalities are prevalent among persons living with HIV infection and contribute to increasing the risk of cardiovascular events. Antiretroviral therapy (ART) is associated with lipid abnormalities, most commonly hypertriglyceridemia, but also increases in low-density lipoprotein cholesterol and total cholesterol. Different classes of ART, and different drugs within classes, have differing effects on lipid levels, but in general newer drugs have more favourable effects compared with older ones. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183127
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http://dx.doi.org/10.1016/j.cjca.2018.11.005DOI Listing
November 2018
6 Reads

A case of apolipoprotein E Toyonaka and homozygous apolipoprotein E2/2 showing non-immune membranous nephropathy-like glomerular lesions with foamy changes.

CEN Case Rep 2019 Jan 30. Epub 2019 Jan 30.

Sanko Clinic, Fukuoka, Japan.

A 47-year-old Japanese man with mild proteinuria was treated with an ACE inhibitor and antiplatelet agent for 7 years. However, urinary protein levels increased and renal biopsy was performed. Eight out of 20 glomeruli showed global or segmental sclerosis with foamy changes or bubbles, but with a different appearance to typical foam cells or lipoprotein thrombi. Read More

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http://link.springer.com/10.1007/s13730-019-00380-w
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http://dx.doi.org/10.1007/s13730-019-00380-wDOI Listing
January 2019
4 Reads

Critical Role of SREBP (Sterol Regulatory Element-Binding Protein)-1c Large-VLDL (Very Low-Density Lipoprotein) Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.

Arterioscler Thromb Vasc Biol 2019 Jan 31:ATVBAHA118311931. Epub 2019 Jan 31.

From the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Japan (Mikio Takanashi, T. Kimura, C.L., A.M., H. Yoshida, A.N., P.X., S.T., S.O., Y. Iizuka, T.G., T.Y., T. Kadowaki, H.O.).

Objective- APOA5 variants are strongly associated with hypertriglyceridemia, as well as increased risks of cardiovascular disease and acute pancreatitis. Hypertriglyceridemia in apo AV dysfunction often aggravates by environmental factors such as high-carbohydrate diets or aging. To date, the molecular mechanisms by which these environmental factors induce hypertriglyceridemia are poorly defined, leaving the high-risk hypertriglyceridemia condition undertreated. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311931DOI Listing
January 2019
1 Read

Triglycerides and triglyceride-rich lipoproteins in the development and progression of atherosclerosis.

Curr Opin Endocrinol Diabetes Obes 2019 Jan 28. Epub 2019 Jan 28.

Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo.

Purpose Of Review: In this review, we intend to show the heterogenicity of the triglyceride group, including the triglyceride-rich lipoproteins and its subparticles, apolipoproteins, and its role in atherogenesis through epidemiological and genetic studies, observing the association of these various components and subclasses with subclinical atherosclerosis and cardiovascular events. Also, we reevaluated the moment of blood collection for the triglyceride measurement and its repercussion in atherosclerosis. Finally, we present the current scenario and new insights about the pharmacologic treatment of hypertriglyceridemia. Read More

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http://dx.doi.org/10.1097/MED.0000000000000468DOI Listing
January 2019

Severe hypertriglyceridemia-induced pancreatitis successfully managed with therapeutic plasma exchange: Report from India.

Asian J Transfus Sci 2018 Jul-Dec;12(2):154-156

Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.

Hypertriglyceridemia (HTG) is the third most significant risk factor for acute pancreatitis after gallstones and alcohol. Therapeutic plasma exchange (TPE) has been considered a possible treatment for HTG-induced pancreatitis, especially in severe and refractory cases. Here, we report one such clinical experience with a patient of severe HTG-induced pancreatitis. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_86_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327775PMC
January 2019
1 Read

Remnant lipoproteins play an important role of in-stent restenosis in type 2 diabetes undergoing percutaneous coronary intervention: a single-centre observational cohort study.

Cardiovasc Diabetol 2019 Jan 28;18(1):11. Epub 2019 Jan 28.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotlic Disease, Clinical Centre for Coronary Heart Disease, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: Increasing evidence has suggested that the presence of remnant lipoproteins is a significant risk factor for atherosclerosis. Remnant lipoproteins are lipoproteins that are rich in triglycerides (TGs), and the main components include very-low-density lipoprotein (VLDL) in the fasting state. Diabetic patients often have hypertriglyceridemia with elevated levels of VLDL cholesterol but normal levels of low-density lipoprotein cholesterol (LDL-C). Read More

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https://cardiab.biomedcentral.com/articles/10.1186/s12933-01
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http://dx.doi.org/10.1186/s12933-019-0819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348605PMC
January 2019
4 Reads

Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: a randomized crossover pilot study.

J Diabetes Investig 2019 Jan 28. Epub 2019 Jan 28.

Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta-Otsu 520-2192, Shiga, Japan.

Aims/introduction: Preprandial metformin administration significantly reduces postprandial plasma triglyceride levels in animal studies by reducing intestinal absorption through delayed gastric emptying. However, this effect has not been shown in a clinical study. Therefore, we planned to investigate the efficacy of preprandial metformin administration on postprandial hypertriglyceridemia and the related gastrointestinal effects in patients with type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.1111/jdi.13016DOI Listing
January 2019

Deciphering the role of V200A and N291S mutations leading to LPL deficiency.

Atherosclerosis 2019 Jan 20;282:45-51. Epub 2019 Jan 20.

Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. Electronic address:

Background And Aims: Type I hyperlipoproteinemia is an autosomal recessive disorder of lipoprotein metabolism caused by mutations in the LPL gene, with an estimated prevalence in the general population of 1 in a million. In this work, we studied the molecular mechanism of two known mutations in the LPL gene in ex vivo and in vitro experiments and also the effect of two splice site mutations in ex vivo experiments.

Methods: Two patients with hypertriglyceridemia were selected from the Lipid Clinic in Vienna. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.004DOI Listing
January 2019
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A young Chinese man with nephrotic syndrome due to lipoprotein glomerulopathy.

J Clin Lipidol 2018 Dec 19. Epub 2018 Dec 19.

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong. Electronic address:

Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant renal disease with incomplete penetrance, associated with specific protein-modifying mutations in the APOE gene. LPG is associated with poor renal prognosis, in which lipoprotein thrombi are seen in the glomerular capillaries. Dyslipidemia in LPG generally resembles type III hyperlipoproteinemia with elevated serum apolipoprotein E level. Read More

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http://dx.doi.org/10.1016/j.jacl.2018.12.004DOI Listing
December 2018
4 Reads

Kawasaki disease shock syndrome complicated with macrophage activation syndrome in a 5-month old boy: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14203

Department of Pediatric Cardiology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.

Rationale: Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology and often occurs in children under 5 years old. During the acute phase, approximately 5% of children with KD develop hypotension and shock, a severe condition termed KD shock syndrome (KDSS). Macrophage activation syndrome (MAS), another life-threatening complication, has been reported to be associated with KD, although rarely. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0004
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http://dx.doi.org/10.1097/MD.0000000000014203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358384PMC
January 2019
3 Reads

Frequency and Risk Factors of Kidney Alterations in Children and Adolescents who Are Overweight and Obese in a Primary Health-care Setting.

J Ren Nutr 2019 Jan 21. Epub 2019 Jan 21.

Unit of Medical Research in Renal Diseases, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Mexico. Electronic address:

Objective: Obesity is clearly associated to kidney disease in adult population; however, there is scarce evidence in children and adolescents. The aim was to compare frequency of renal damage according to the presence of overweight-obesity in children and adolescents, as well as to compare nutritional and biochemical risk factors, according to the presence of kidney alterations.

Methods: Cross-sectional study; 172 children and adolescents, 6-16 years old, without malnutrition, diabetes mellitus, hypertension and independent comorbid conditions associated to obesity or kidney disease, as well as transitory causes of microalbuminuria (MA) from a Primary Health-Care Unit were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10512276183027
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http://dx.doi.org/10.1053/j.jrn.2018.11.005DOI Listing
January 2019
3 Reads

Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia.

Blood Cells Mol Dis 2018 Dec 28. Epub 2018 Dec 28.

Laboratório de Imunobiologia Experimental e Aplicada (LABIBIO), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Hyperlipidemia is associated with endothelial dysfunction and inflammatory disorders. Adenosine and adenosine deaminase (ADA) modulate immune responses and lipid metabolism. Curcumin and rutin are polyphenols with antioxidant, anti-inflammatory, and hypolipidemic effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10799796183044
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http://dx.doi.org/10.1016/j.bcmd.2018.12.005DOI Listing
December 2018
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Fenofibrate Solid Dispersion Processed by Hot-melt Extrusion: Elevated Bioavailability and Its Cell Transport Mechanism.

Curr Drug Deliv 2019 Jan 22. Epub 2019 Jan 22.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006. China.

Background: Fenofibrate (FNB) is an effective drug for the treatment of hypertriglyceridemia, hypercholesterolemia as well as mixed hyperlipidemia. However, due to its poor aqueous solubility, FNB exists the problem of poor oral absorption followed by low bioavailability.

Objective: The aim of this research was to construct FNB amorphous solid dispersion employing PVP VA64 as the carrier by hot-melt extrusion method, in order to improve the oral bioavailability. Read More

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http://dx.doi.org/10.2174/1567201816666190122123044DOI Listing
January 2019

Association between Dyslipidemia and Nephrolithiasis Risk in a Chinese Population.

Urol Int 2019 Jan 23:1-10. Epub 2019 Jan 23.

Department of Gastroenterology, The Changshu Hospital Affiliated to Soochow University, Changshu, China.

Purpose: To evaluate the association between dyslipidemia and nephrolithiasis risk in a Chinese population.

Materials And Methods: Fasting plasma lipid profiles were measured in a case-control study of 540 nephrolithiasis cases and 656 kidney stone-free controls.

Results: Triglycerides (TG) levels were significantly higher, but total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were significantly lower in nephrolithiasis patients than those in the control group (each p < 0. Read More

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https://www.karger.com/Article/FullText/496208
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http://dx.doi.org/10.1159/000496208DOI Listing
January 2019
3 Reads
1.151 Impact Factor

[The gender features of disorders of composition of lipids of blood serum in patients with chronic pathology of kidneys.]

Klin Lab Diagn 2018 ;63(3):152-158

The I.K. Akhunbaiev Kirghiz State Medical Academy, 720020, Bishkek, Kyrgyzstan.

The purpose of the study was to investigate gender features of abnormalities of blood serum lipid composition and their relationship with clinical and functional manifestations in patients with chronic kidney disease (CKD). The study covered patients with CKD at pre-dialysis stage of disease, aged 17 - 71 years (average age 37.3±13. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-3-152-158DOI Listing
January 2018
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The triglyceride paradox in the mortality of coronary artery disease.

Lipids Health Dis 2019 Jan 22;18(1):21. Epub 2019 Jan 22.

Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, 610041, People's Republic of China.

Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.

Methods: A retrospective analysis was conducted from a single registered database. Read More

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http://dx.doi.org/10.1186/s12944-019-0972-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343235PMC
January 2019
1 Read

Medicinal plants in treatment of hypertriglyceridemia: A review based on their mechanisms and effectiveness.

Phytomedicine 2019 Feb 5;53:43-52. Epub 2018 Sep 5.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamic and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Hypertriglyceridemia (HTg) defines as high amounts of triglyceride (TG) in the blood which can lead to serious complications over time. HTg is usually a part of metabolic disorders such as diabetes mellitus, metabolic syndrome, and dyslipidemia. Different medications have been used to treat HTg but experimentally, many herbs have been recommended for treating HTg as an adjuvant therapy. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.09.024DOI Listing
February 2019
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Evaluation of hypertriglyceridemia-induced acute pancreatitis: A single tertiary care unit experience from Turkey.

Turk J Gastroenterol 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterology, Mersin University School of Medicine, Mersin, Turkey.

Background/aims: This study aimed to determine the frequency of hypertriglyceridemia (HTG)-induced acute pancreatitis (AP) and assess different clinical and prognostic features in these patients.

Materials And Methods: The patients who were hospitalized with AP due to HTG (HTG-AP) between January 2005 and December 2014 were retrospectively evaluated in the clinic. The patients with AP due to non-HTG (non-HTG-AP) were also investigated during the same period. Read More

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http://dx.doi.org/10.5152/tjg.2018.18292DOI Listing
January 2019
3 Reads

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans.

Emerg Infect Dis 2019 Feb;25(2):290-298

Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Read More

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http://dx.doi.org/10.3201/eid2502.181326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346465PMC
February 2019
2 Reads

Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303.

Thorac Cancer 2019 Jan 21. Epub 2019 Jan 21.

Department of Respiratory Diseases, Tangdu Hospital, Xi'an, China.

Background: Anlotinib is an oral tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, and stem cell factor receptor (c-Kit). In the phase III ALTER-0303 trial (Clinical Trial Registry ID: NCT 02388919), anlotinib significantly improved overall survival versus placebo in advanced non-small cell lung cancer patients who had received at least two previous chemotherapy and epidermal growth factor receptor/anaplastic lymphoma kinase targeted therapy regimens. This study summarized adverse event management in this trial. Read More

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http://doi.wiley.com/10.1111/1759-7714.12977
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http://dx.doi.org/10.1111/1759-7714.12977DOI Listing
January 2019
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Increased trunk fat along with decreased peripheral fat as an important predictor of hypertriglyceridaemia & hypercholesterolaemia in Indians with HIV infection.

Indian J Med Res 2018 Oct;148(4):411-421

Department of Biochemistry, Post Graduate Institute of Medical Education & Research & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background & Objectives: Dyslipidaemia is a major contributor to cardiovascular morbidity, which is increased in HIV. Data on dyslipidaemia in Indians with HIV are scant. This study was undertaken to determine the predictors of dyslipidaemia and lipoatrophy in Indians with HIV infection and their relation with body composition parameters. Read More

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http://www.ijmr.org.in/text.asp?2018/148/4/411/250537
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http://dx.doi.org/10.4103/ijmr.IJMR_236_17DOI Listing
October 2018
4 Reads