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    13959 results match your criteria Hypertriglyceridemia

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    Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013-2014.
    Environ Pollut 2017 Sep 15. Epub 2017 Sep 15.
    School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan; Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan. Electronic address:
    Perfluorinated chemicals (PFCs) have been used widely in consumer products manufacture. Recent in vitro as well as animal studies have found that there are different toxicity and pharmacokinetic profiles between isomers of perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS). However, the differential effects of linear or branched PFOA/PFOS isomers on human beings have never been reported. Read More

    Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report.
    Rom J Intern Med 2017 Sep 16. Epub 2017 Sep 16.
    .
    Introduction: Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs) are the cornerstone of SLE therapy. Read More

    Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status.
    Diabetes Metab 2017 Sep 14. Epub 2017 Sep 14.
    Department of Internal Medicine, Niigata University Faculty of Medicine, 1-757, Asahimachi, 951-8510 Niigata, Japan. Electronic address:
    Objective: This study aimed to examine the impact of obesity, as defined by body mass index (BMI), and a metabolically unhealthy phenotype on the development of coronary artery disease (CAD) according to glucose tolerance status.

    Methods: This population-based retrospective cohort study included 123,746 Japanese men aged 18-72years (normal glucose tolerance: 72,047; prediabetes: 39,633; diabetes: 12,066). Obesity was defined as a BMI≥25kg/m(2). Read More

    Use of lipid emulsion therapy in local anesthetic overdose.
    Saudi Med J 2017 Oct;38(10):985-993
    Department of Emergency Medicine, University of Health Sciences, Istanbul Education and Research Hospital, Istanbul, Turkey. E-mail.
    The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment ("lipid sink"). Read More

    A case of severe acquired hypertriglyceridemia in a 7-year-old girl.
    J Clin Lipidol 2017 Aug 12. Epub 2017 Aug 12.
    Department of Medicine, Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:
    We report a case of severe type I hyperlipoproteinemia caused by autoimmunity against lipoprotein lipase (LPL) in the context of presymptomatic Sjögren's syndrome. A 7-year-old mixed race (Caucasian/African American) girl was admitted to the intensive care unit at Vanderbilt Children's Hospital with acute pancreatitis and shock. She was previously healthy aside from asthma and history of Hashimoto's thyroiditis. Read More

    Clinical and molecular characterization of two Chinese patients with Type 2 congenital generalized lipodystrophy.
    Gene 2017 Sep 12. Epub 2017 Sep 12.
    Department of Endocrinology, Fuzhou Children's Hospital of Fujian, Fujian Medical University Teaching Hospital, Fuzhou 350005, China.
    Background: Type 2 congenital generalized lipodystrophy (CGL2, OMIM 269700) is a rare autosomal recessive disease, characterized by the generalized absence of adipose tissue at birth or in early infancy. Pathogenic variants in BSCL2 gene have been reported to be responsible for CGL2. The aim of this study is to analyze the clinical and genetic characteristics of two Chinese patients with CGL2, and with particular focus on the BSCL2 gene sequence variants. Read More

    Nutrition in primary and secondary prevention of cardiovascular risk in the continental and Mediterranean regions of Croatia.
    BMC Cardiovasc Disord 2017 Sep 16;17(1):247. Epub 2017 Sep 16.
    Division of Cardiology, Department of Internal Medicine, Sveti Duh University Hospital, Zagreb, Croatia.
    Background: The aim of this observational study was to evaluate the effect of Mediterranean and continental nutrition on cardiovascular risk in patients with acute and chronic coronary heart disease in Croatia.

    Methods: The study included 1284 patients who were hospitalized in a 28-month period due to acute or chronic ischaemic heart disease in hospitals across Croatia. An individual questionnaire was prepared which enabled recording of various cardiovascular risk factors. Read More

    [Therapeutic options in hyperlipidemia].
    Wien Med Wochenschr 2017 Sep 14. Epub 2017 Sep 14.
    Institute for Diagnosis and Treatment of Atherosclerosis and Lipid Disorders, Institut ATHOS, Wien, Österreich.
    Treatment of lipid disorders (dyslipidemia) is the cornerstone of atherosclerosis prevention and reduction of progression. Lifestyle modification is the first step to improve the plasma lipid profile. Statins play a central role in the reduction of LDL cholesterol. Read More

    Prevalence of metabolic syndrome among elderly Mexicans.
    Arch Gerontol Geriatr 2017 Sep 7;73:288-293. Epub 2017 Sep 7.
    Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands & CIBEROBN, Palma de Mallorca, Spain. Electronic address:
    Background: One of the most prevalent chronic diseases among elderly population is the Metabolic Syndrome (MetS). The aim of this study was to assess the prevalence of MetS and associated factors among Mexican elderly people.

    Subjects: Cross-sectional survey carried out in Mexico (2007). Read More

    Prevalence of Metabolic Syndrome in Psoriasis and Levels of Interleukin-6 and Tumor Necrosis Factor-α in Psoriasis Patients with Metabolic Syndrome: Indian Tertiary Care Hospital Study.
    Int J Appl Basic Med Res 2017 Jul-Sep;7(3):169-175
    Department of Pharmacology, PGIMER, Chandigarh, India.
    Background: Psoriasis is a chronic inflammatory multisystem disease, found to be associated with metabolic syndrome (MS) and increased levels of cytokines. To evaluate the prevalence of MS in psoriasis and to determine the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in psoriasis patients with MS.

    Methods: Observational study on 334 psoriasis patients and 230 controls. Read More

    Balanced Coagonist of GLP-1 and Glucagon Receptors Corrects Dyslipidemia by Improving FGF21 Sensitivity in Hamster Model.
    Drug Res (Stuttg) 2017 Sep 12. Epub 2017 Sep 12.
    Department of Pharmacology & Toxicology, Zydus Research Centre, Cadila Healthcare Limited, Moraiya, Ahmedabad, India.
    Hyperlipidemia is often associated with obesity and diabetes, and can lead to serious complications like atherosclerosis and fatty liver disease. Coagonist of GLP-1 and glucagon receptors is a therapy under clinical investigation for treatment of obesity and diabetes. In this study, we have characterized the mechanism of hypolipidemic effect of a balanced coagonist using high cholesterol-fed hamsters. Read More

    Indispensable role of lipoprotein bound-ApoE in adipogenesis and endocytosis induced by postprandial TRL.
    Biochem Biophys Res Commun 2017 Sep 9. Epub 2017 Sep 9.
    Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Research Institute of Blood Lipid and Atherosclerosis, Central South University, Changsha, Hunan, PR China. Electronic address:
    Diet-associated obesity is coexisted with postprandial hypertriglyceridemia that indicates increased number of triglyceride-rich lipoproteins (TRL). This study aimed to investigate the effect of postprandial TRL-bound apolipoprotein E (ApoE) on adipogenesis and potential mechanisms. 3T3-L1 cells were cultured with (i) human TRL (h-TRL) with or without insulin, or (ii) TRL from wild type mice (WT-TRL) or ApoE knock-out mice (EKO-TRL) and insulin. Read More

    The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.
    J Lipid Res 2017 Sep 8. Epub 2017 Sep 8.
    University of Ottawa, Canada;
    Recent cell culture and animal studies have suggested expression of human apolipoprotein (apo) C-III in the liver has a profound impact on the triacylglycerol (TAG)-rich VLDL1 production under lipid-rich conditions. The apoC-III Gln38Lys variant was identified in subjects of Mexican origin with moderate hypertriglyceridemia. We postulated that Gln38Lys (C3QK), being a gain-of-function mutation, promotes hepatic VLDL1 assembly/secretion. Read More

    Severe Hypertriglyceridemia Possibly Masked Acute Pancreatitis and Led to a Difficult Diagnosis in an Obese Patient with Ketoacidosis-onset Type 2 Diabetes.
    Intern Med 2017 Sep 6. Epub 2017 Sep 6.
    Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Japan.
    A young obese man with ketoacidosis-onset type 2 diabetes mellitus, associated with severe hypertriglyceridemia, was admitted to a local hospital complaining of abdominal pain. Although the abdominal pain worsened, his serum amylase level remained normal with persistent severe hypertriglyceridemia until the second day of hospitalization. The next day, computed tomography showed severe acute pancreatitis (AP) with serum amylase elevation, while the patient's triglyceride level decreased to 558 mg/dL. Read More

    Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling.
    Oncotarget 2017 Aug 16;8(32):53450-53464. Epub 2017 Jun 16.
    The Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, China.
    Maternal obesity influence the child's long-term development and health. Though, the mechanism concerned in this process is still uncertain. In the present study, we explored whether overfeeding of a high-fat diet during pregnancy in female rats altered metabolic phenotypes in an F1 generation and authenticated the contribution of hypothalamic leptin signaling. Read More

    Prevalence, awareness, treatment and control of diabetes and impaired fasting glucose in the Southern Cone of Latin America.
    PLoS One 2017 6;12(9):e0183953. Epub 2017 Sep 6.
    Department of Epidemiology and Department of Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
    Aims: To determine the prevalence, treatment and control of diabetes mellitus (DM) and impaired fasting glucose (IFG) as well as associated factors in the adult population of four cities of the Southern Cone of Latin America (SCLA).

    Methods: This is a cross-sectional population-based study that included 7407 adults between 35 and 74 years old in four cities of the SCLA: Temuco (Chile), Marcos Paz and Bariloche (Argentina), and Pando-Barros Blancos (Uruguay). DM was defined as fasting plasma glucose ≥126 mg/dL or self-reported history of diabetes. Read More

    Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate.
    J Lipid Res 2017 Sep 5. Epub 2017 Sep 5.
    Saint Louis University, United States;
    Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD progresses from benign steatosis to steatohepatitis (NASH) to cirrhosis, and is linked to hepatocellular carcinoma. No targeted treatment is currently approved for NAFLD/NASH. Read More

    Postprandial triglyceride responses and endothelial function in prediabetic first-degree relatives of patients with diabetes.
    J Clin Lipidol 2017 Aug 8. Epub 2017 Aug 8.
    Department of Medicine, University College of Medical Sciences & GTB Hospital, Delhi, India; Department of Cardiology, National Heart Institute, New Delhi, India.
    Background: Only a few studies have reported on postprandial lipid responses and endothelial function in prediabetic subjects. None of the study has compared role of familial predisposition in determining postprandial endothelial dysfunction and postprandial hypertriglyceridemia in subjects with prediabetes.

    Objective: The objective was to study the postprandial triglyceride (PPTG) responses and endothelial function in prediabetic first-degree relatives of patients with diabetes. Read More

    Approach to Hypertriglyceridemia in the Pediatric Population.
    Pediatr Rev 2017 Sep;38(9):424-434
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Children's of Alabama, University of Alabama at Birmingham, Birmingham, AL.
    Hypertriglyceridemia is increasingly identified in children and adolescents, owing to improved screening and higher prevalence of childhood obesity. Hypertriglyceridemia can result from either increased triglyceride (TG) production or reduced TG clearance. The etiologic origin can be primary (genetic) or secondary, but it is often multifactorial. Read More

    Effect of Combination Therapy of Ezetimibe and Atorvastatin on Remnant Lipoprotein Versus Double Atorvastatin Dose in Egyptian Diabetic Patients.
    J Clin Pharmacol 2017 Aug 31. Epub 2017 Aug 31.
    Diagnostic Radiology Department, College of Medicine, Tanta University, Tanta, Egypt.
    A high level of remnant lipoprotein cholesterol (RLP-C) is a predominant feature in diabetic patients with atherosclerosis. This study aimed to investigate the effect of ezetimibe added to statin therapy compared to doubling standard statin dose. Sixty-five eligible patients were recruited then prospectively randomized to receive ezetimibe 10 mg/day plus their 40 mg daily atorvastatin dose (group 1) or atorvastatin 80 mg/day (group 2) for 3 months. Read More

    Serum ghrelin, but not obestatin, is a potential predictor of acute pancreatitis severity.
    Medicine (Baltimore) 2017 Sep;96(35):e7963
    aDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University bDepartment of Chemotherapy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
    The roles of ghrelin and obestatin in AP remain controversial.This study investigates the effects and the predictive value of serum ghrelin and obestatin levels in the early stage of AP.A total of 193 consecutive patients with AP and 24 healthy controls were included. Read More

    DIFFERENT PATTERNS OF WALKING AND POSTPRANDIAL TRIGLYCERIDES IN OLDER WOMEN.
    Med Sci Sports Exerc 2017 Aug 29. Epub 2017 Aug 29.
    1Graduate School of Sport Sciences, Waseda University, Saitama, Japan; 2Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan; 3Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan; 4Physical Education and Sports Science Academic Group, Nanyang Technological University, Singapore; 5National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom; 6Faculty of Sport Sciences, Waseda University, Saitama, Japan.
    Purpose: Although a single bout of continuous exercise (≥30 min) reduces postprandial triglyceride (TG), little evidence is available regarding the effect of multiple short (≤10 min) bouts of exercise on postprandial TG in individuals at increased risk of cardiovascular diseases. This study compared the effect of different patterns of walking on postprandial TG in postmenopausal, older women with hypertriglyceridemia.

    Methods: Twelve inactive women (aged 71 ± 5 yrs, mean ± S. Read More

    The triglycerides and glucose index is associated with cardiovascular risk factors in normal-weight children and adolescents.
    Pediatr Res 2017 Aug 30. Epub 2017 Aug 30.
    Biomedical Research Unit of the Mexican Social Security Institute at Durango, Durango, México.
    BackgroundGiven the usefulness of the product of triglycerides and glucose (TyG) to recognize individuals at high risk for developing cardiovascular events, the aim of this study was to determine whether the TyG index is associated with the presence of cardiovascular risk factors in apparently healthy normal-weight children and adolescents.MethodsApparently healthy children and adolescents with normal weight, aged 6-15 years, were enrolled in a population-based cross-sectional study. The children were allocated into groups with and without cardiovascular risk factors. Read More

    Unawareness of Hepatitis B Virus Infection confers on Higher Rate of Metabolic Syndrome: A Community-based Study.
    Sci Rep 2017 Aug 29;7(1):9869. Epub 2017 Aug 29.
    Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C..
    The objective of this study was to determine whether awareness of hepatitis B virus (HBV) serostatus was discordant with metabolic syndrome (MetS) among people with chronic HBV infection. We conducted a community-based study in four Taiwanese districts. A total of 3493 adult participants were recruited. Read More

    Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib.
    Br J Cancer 2017 Aug 29. Epub 2017 Aug 29.
    Gustave Roussy, Villejuif, France.
    Background: This multicentre phase II trial (DOVIGIST) evaluated the antitumour activity of dovitinib as second-line treatment of patients with gastrointestinal stromal tumour (GIST) refractory to imatinib or who do not tolerate imatinib.

    Methods: Patients received oral dovitinib 500 mg day(-1), 5 days on/2 days off, until GIST progression or unacceptable toxicity, with an objective to evaluate efficacy, assessed as the disease control rate (DCR) at 12 weeks. Tumour assessment and response to dovitinib therapy were evaluated by Response Evaluation Criteria In Solid Tumours (RECIST v1. Read More

    Triglyceride metabolism in Japanese kidney transplant recipients.
    Clin Exp Nephrol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Kidney Disease Center, Nagoya Daini Red Cross Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
    Background: Residual cardiovascular risk factors, such as triglyceride (TG), can cause cardiovascular disease. The role of TG metabolism in kidney transplantation remains unclear.

    Methods: Sixty-three consecutive stable recipients at 1 year after their kidney transplants were included in the study from January to September 2014 at Nagoya Daini Red Cross Hospital. Read More

    Relationship of Serum Apolipoprotein A-V Levels, Oxidative Stress and Inflammatory Biomarkers with Hypertriglyceridemia in Type 2 Diabetes Mellitus.
    Int J Endocrinol Metab 2017 Apr 22;15(2):e44805. Epub 2017 Apr 22.
    Departement of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
    Background: Serum levels of triglycerides (TGs) are often found to be raised in type 2 diabetes mellitus (T2DM). TG levels ≥ 2.2 mM, systemic inflammation and oxidative stress (OS) are known to increase the risk of incident cardiovascular disease (CVD) substantially. Read More

    Sex difference in the association of serum uric acid with metabolic syndrome and its components: a cross-sectional study in a Chinese Yi population.
    Postgrad Med 2017 Aug 31:1-6. Epub 2017 Aug 31.
    a School of Public Health , Southwest Medical University , Luzhou , China.
    Objectives: Since the association between serum uric acid (SUA) and metabolic syndrome (MetS) has been reported extensively, it remains unclear whether SUA is associated with MetS and its components in a Chinese Yi population.

    Methods: This study recruited 1,903 people (912 men, 991 women) older than 18 years old from the Liangshan region in Sichuan province. Anthropometric measurements and biochemical indexes were measured by a standard protocol. Read More

    The burden of familial chylomicronemia syndrome from the patients' perspective.
    Expert Rev Cardiovasc Ther 2017 Sep 11:1-9. Epub 2017 Sep 11.
    c Division of Cardiology , Advocate Lutheran General Hospital , Park Ridge , IL , USA.
    Background: Familial chylomicronemia syndrome (FCS) is a rare, inherited lipid disorder characterized by high levels of plasma triglycerides and chylomicrons, which may cause life-threatening acute pancreatitis. Currently no FDA-approved treatment exists. Management is low-fat diet (<20g fat/day), which is difficult to maintain. Read More

    Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study.
    J Diabetes Res 2017 3;2017:9294038. Epub 2017 Aug 3.
    Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, Italy.
    There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD_2 study were investigated. Read More

    Elevated levels of very low-density lipoprotein cholesterol independently associated with in-stent restenosis in diabetic patients after drug-eluting stent implantation.
    Chin Med J (Engl) 2017 Aug 22. Epub 2017 Aug 22.
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University; Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Beijing 100029, China.
    Background: High rate of in-stent restenosis (ISR) remained an unsolved clinical problem in clinical practice, especially among patients with diabetes mellitus (DM). Diabetic patients often had hypertriglyceridemia with elevated levels of very low-density lipoprotein cholesterol (VLDL-C). Increasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines. Read More

    Fatty Acid Metabolic Remodelling During Type 2 Diabetes Remission After Bariatric Surgery.
    Diabetes 2017 Aug 23. Epub 2017 Aug 23.
    Department of Medicine, Division of Endocrinology, Centre de recherche du CHUS, Université de Sherbrooke, Québec, Canada
    Hypertrophic remodelling of white adipose tissues is associated with lean organs overexposure to circulating triglycerides (TG) and non-esterified fatty acids (NEFA), ultimately leading to insulin resistance. Bariatric surgery promotes type 2 diabetes (T2D) remission by a succession of weight-loss dependent and independent mechanisms. However, the longitudinal contribution of adipocytes size reduction and fatty acid metabolic handling remain unknown. Read More

    Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study.
    Sci Rep 2017 Aug 22;7(1):9072. Epub 2017 Aug 22.
    Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
    Limited information is available on the effect of hypertriglyceridemia-waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Read More

    Alterations in plasma triglycerides lipolysis in patients with history of multifactorial chylomicronemia.
    Atherosclerosis 2017 Jul 29;265:22-28. Epub 2017 Jul 29.
    Univ-Lyon, CarMeN Laboratory, Inserm U1060, INRA U1397, Université Claude Bernard Lyon 1, INSA Lyon, F-69100, Villeurbanne, France; Fédération d'endocrinologie, Maladies Métaboliques, Diabète et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677, Bron Cedex, France.
    Background And Aims: The heterogeneity and mechanisms of multifactorial chylomicronemia (MCM) remain poorly understood. To gain new insights, post heparin lipolysis measured at 60 min (PHLA60), in addition to the more commonly used 10 min (PHLA10), was assessed in patients with history of MCM.

    Methods: 62 consecutive MCM patients were studied. Read More

    [Severely increased serum lipid levels in diabetic ketoacidosis - case report].
    Laeknabladid 2017 Juli;103(7):331-333
    Severe hypertriglyceridemia is a known, but uncommon complication of diabetic ketoacidosis. We discuss the case of a 23-year-old, previously healthy, woman who initially presented to the emergency department with abdominal pain. Grossly lipemic serum due to extremely high triglyceride (38. Read More

    Artemisia Iwayomogi Extract Attenuates High-Fat Diet-Induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low Density Lipoprotein Assembly in the Liver.
    Int J Mol Sci 2017 Aug 12;18(8). Epub 2017 Aug 12.
    Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
    This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0. Read More

    Triglycerides and Open Angle Glaucoma - A Meta-analysis with meta-regression.
    Sci Rep 2017 Aug 10;7(1):7829. Epub 2017 Aug 10.
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
    Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glaucoma. The objective of this meta-analysis was to investigate the association of triglyceride levels with the risk of glaucoma in case-control studies. Read More

    The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence.
    Biosci Rep 2017 Aug 30;37(4). Epub 2017 Aug 30.
    Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
    It has been shown that adipose tissue and skeletal muscles in lean individuals respond to meal-induced hyperinsulinemia by increase in perfusion, the effect not observed in patients with metabolic syndrome. In conditions of hyperglycaemia and hypertriglyceridemia, this insufficient vascularization leads to the liberation of reactive oxygen species (ROS), and disruption of nitric oxide (NO) synthesis and endothelial signalling responsible for the uptake of circulating fatty acids (FAs), whose accumulation in skeletal muscles and adipose tissue is widely associated with the impairment of insulin signalling. While the angiogenic role of VEGF-A and its increased circulating concentrations in obesity have been widely confirmed, the data related to the metabolic role of VEGF-B are diverse. Read More

    Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
    Lipids Health Dis 2017 Aug 10;16(1):149. Epub 2017 Aug 10.
    AstraZeneca Gothenburg, Pepparedsleden 1, SE-431 83, Mölndal, Sweden.
    Background: Epidemiological and genetic studies suggest that elevated triglyceride (TG)-rich lipoprotein levels in the circulation increase the risk of cardiovascular disease. Prescription formulations of omega-3 fatty acids (OM3FAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma TG levels and are approved for the treatment of patients with severe hypertriglyceridemia. Many preclinical studies have investigated the TG-lowering mechanisms of action of OM3FAs, but less is known from clinical studies. Read More

    Cardiovascular risk and dyslipidemia among persons living with HIV: a review.
    BMC Infect Dis 2017 Aug 9;17(1):551. Epub 2017 Aug 9.
    Divisione Malattie Infettive AO S. Gerardo, Monza, Italy.
    Background: Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or fibrate to reduce the risk? How to influence behavior and lifestyles?

    Discussion: Prevention of cardiovascular disease (CVD) risk remains the first and essential step in a medical intervention on these patients. The lifestyle modification, including smoking cessation, increased physical activity, weight reduction, and the education on healthy dietary practices are the main instruments. Read More

    Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis.
    Cien Saude Colet 2017 Aug;22(8):2659-2669
    Escola de Nutrição, Unirio. Rio de Janeiro RJ Brasil.
    Hypertriglyceridemia is common in antiretroviral therapy-treated patients and Omega 3 fatty acids are being used as a intervention in reducing serum triglycerides (TG) in these patients. The objective of this study is to evaluate the effectiveness of the use of Omega 3 in the treatment of hypertriglyceridemia in HIV/AIDS patients on antiretroviral therapy. This study is a systematic review with meta-analysis of randomized clinical trials. Read More

    [Dyslipidemias : Diagnostics and management].
    Herz 2017 Aug 8. Epub 2017 Aug 8.
    Klinik für Kardiologie, Charité Centrum für Herz‑, Kreislauf- und Gefäßmedizin, Charité - Universitätsmedizin Berlin (Campus Benjamin Franklin), Hindenburgdamm 30, 12203, Berlin, Deutschland.
    For disorders of lipid metabolism the risk-adapted adjustment of low-density lipoprotein (LDL) cholesterol remains the primary treatment target, as a causal role in minimizing the progression of ACVD has been shown. Because of their efficacy in reducing cardiovascular morbidity and mortality, statins are recommended as first-line pharmacological treatment in dyslipidemias. Additionally, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition have been shown to significantly reduce cardiovascular events in high-risk patients. Read More

    Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.
    Rev Esp Cardiol (Engl Ed) 2017 Aug 5. Epub 2017 Aug 5.
    Departamento de Medicina Preventiva, Salud Pública e Historia de la Ciencia, Universidad Complutense de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
    Introduction And Objectives: Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin).

    Methods: Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase). Read More

    Metabolic Abnormalities and Clinical Lipodystrophy in Children with Human Immunodeficiency Virus Infection: A Report from A Tertiary-Care-Center in India.
    Pediatr Infect Dis J 2017 Aug 3. Epub 2017 Aug 3.
    Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India- 160012.
    A cross-sectional study from a tertiary-care-center in India was undertaken to assess and compare the prevalence of blood glucose and lipid profile aberrations in children who received first-line anti-retroviral therapy (ART) (n=63) and in children who were naïve to ART (n=46).Impaired fasting blood glucose values were found in 7 children in ART-experienced group but none in ART-naïve group (p=0.02). Read More

    Comparison of Metabolic Syndrome Indicators in Two Samples of Central and South Americans Living in the Washington, D.C. Area in 1993-1994 and 2008-2009: Secular Changes in Metabolic Syndrome in Hispanics.
    Int J Environ Res Public Health 2017 Aug 5;14(8). Epub 2017 Aug 5.
    Department of Nutrition and Food Science, University of Maryland, College Park, MD 20740, USA.
    The Central and South American populations are growing rapidly in the US; however, there is a paucity of information about their health status. Objectives: we estimated the prevalence of metabolic syndrome (MetS) and its individual components from two cohorts of Central and South Americans. Methods: This cross-sectional, medical record extraction survey sampled 1641 adults from a Washington, D. Read More

    Lipid Profile in Childhood-and Youth-Onset Type 2 Diabetes and their Association with Microvascular Complications.
    J Assoc Physicians India 2017 Jun;65(6):42-47
    President, Madras Diabetes Research Foundation and Chairman, Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu.
    Aim: To assess the lipid profiles in childhood and youth onset type 2 diabetes (T2DM) and study their association with microvascular complications.

    Methods: Clinical details of individuals with childhood and youth onset T2DM, age at diagnosis between 10 and 25 yrs (n=1340) were retrieved from electronic medical records. Lipid abnormalities were classified based on the NCEP (ATP III) guidelines and management of dyslipidemia in children and adolescents with diabetes. Read More

    A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice.
    J Atheroscler Thromb 2017 Aug 5. Epub 2017 Aug 5.
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    Aims: Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have atherogenic effects. Fibrates can improve fasting and PHTG; however, reduction of remnants is clinically needed to improve health outcomes. In the current study, we investigated the effects of a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), K-877 (Pemafibrate), on PHTG and remnant metabolism. Read More

    Urbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles.
    J Clin Lipidol 2017 Jul 5. Epub 2017 Jul 5.
    CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Department of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru. Electronic address:
    Background: Geographical and environmental features such as urbanization and altitude may influence individual's lipid profiles because of the diversity of human-environment interactions including lifestyles.

    Objective: To characterize the association between altitude and urbanization and lipid profile among Peruvian adults aged ≥35 years.

    Methods: Cross-sectional analysis of the CRONICAS Cohort Study. Read More

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