17,457 results match your criteria Hypertriglyceridemia


The analysis of risk factors for diabetic kidney disease progression: a single-centre and cross-sectional experiment in Shanghai.

BMJ Open 2022 Jun 28;12(6):e060238. Epub 2022 Jun 28.

Tongren Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China

Objective: To identify the risk factors for diabetic kidney disease (DKD) development, especially the difference between patients with different courses.

Patients And Methods: 791 patients were considered to be eligible and were enrolled in the cross-sectional study from Shanghai Tongren Hospital Inpatient Department. 36 variables were initially screened by univariate analysis. Read More

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Lifestyle school-based intervention to increase the proportion of adolescents free of components of the metabolic syndrome in an andean region of Peru.

Rev Peru Med Exp Salud Publica 2022 Jan-Mar;39(1):36-46. Epub 2022 Jun 24.

Facultad de Medicina Humana, Universidad de Piura. Lima, Perú.

Objective.: To estimate the impact of a school-based nutritional and healthy lifestyle intervention to increase the proportions of adolescents free of components of the metabolic syndrome.

Materials And Methods. Read More

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Prospective Validation of a Machine Learning Model for Low-Density Lipoprotein Cholesterol Estimation.

Lab Med 2022 Jun 28. Epub 2022 Jun 28.

Faculty of Medicine, Université Saint Joseph, Beirut, Lebanon.

Objective: We aim to prospectively validate a previously developed machine learning algorithm for low-density lipoprotein cholesterol (LDL-C) estimation.

Methods: We retrospectively and prospectively evaluated a machine learning algorithm based on k-nearest neighbors (KNN) according to age, sex, healthcare setting, and triglyceridemia against a direct LDL-C assay. The agreement of low-density lipoprotein-k-nearest neighbors (LDL-KNN) with the direct measurement was assessed using intraclass correlation coefficient (ICC). Read More

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Safety and efficacy of therapies for chylomicronemia.

Expert Rev Clin Pharmacol 2022 Jun 28. Epub 2022 Jun 28.

Department of Medicine, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, Ontario N6A 5B7, Canada.

Introduction: Primary chylomicronemia is characterized by pathological accumulation of chylomicrons in plasma causing severe hypertriglyceridemia, typically >10 mmol/L (>875 mg/dL). Patients with the ultra-rare familial chylomicronemia syndrome (FCS) subtype completely lack lipolytic capacity and respond minimally to traditional triglyceride-lowering therapies. The mainstay of treatment is a low-fat diet, which is difficult to follow and compromises quality of life. Read More

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Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals.

Metabolism 2022 Jun 24:155247. Epub 2022 Jun 24.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Aims: Hypertriglyceridemia is associated with an increased risk of type 2 diabetes. We aimed to comprehensively examine the effects of hypertriglyceridemia on major glucose homeostatic mechanisms involved in diabetes progression.

Methods: In this randomized, cross-over, single-blinded study, two dual-labeled, 3-hour oral glucose tolerance tests were performed during 5-hour intravenous infusions of either 20 % Intralipid or saline in 12 healthy subjects (age 27. Read More

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HYPERLIPIDEMIA AND XANTHOMATOSIS IN YELLOW-FOOTED ROCK WALLABIES () UNDER MANAGED CARE.

J Zoo Wildl Med 2022 Jun;53(2):470-479

Department of Medicine and Epidemiology and Karen C. Drayer Wildlife Health Center, University of California Davis School of Veterinary Medicine, Davis, CA 95616, USA.

Xanthomas are localized lipid deposits in organs with associated granulomatous inflammation. Xanthomatosis is a rare condition in both human and veterinary medicine and is often linked to inherited or acquired dyslipidemias. Three female yellow-footed rock wallabies () at a single institution were diagnosed via biopsy with cutaneous xanthomas secondary to hypertriglyceridemia and hypercholesterolemia, and an additional two female yellow-footed rock wallabies were diagnosed with xanthomas at a second institution. Read More

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ASSOCIATIONS OF ENOS GLU298ASP (G894T) ENDOTHELIAL DYSFUNCTION GENE POLYMORPHISMS WITH METABOLIC DISORDERS IN PATHOLOGICAL PREGNANCY.

Wiad Lek 2022 ;75(5 pt 2):1362-1369

IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.

Objective: The aim: To determine the association between the Glu298Asp (G894T) polymorphisms of the eNOS gene with metabolic disorders in excessive gestational weight gain (GWG) pregnancy.

Patients And Methods: Materials and methods: 97 pregnant women in 9-12, and 37-39 weeks of gestation were examined. The recommended GWG was diagnosed in 33 (34. Read More

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The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study.

Diabetes Metab Syndr Obes 2022 20;15:1885-1895. Epub 2022 Jun 20.

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: The aim of this study was measuring the association between the hypertriglyceridemic-waist (HTGW) phenotype and chronic kidney disease in a large type 2 diabetes population.

Methods: A total of 4254 diabetic patients from the cross-sectional Environmental Pollutant Exposure and Metabolic Diseases in Shanghai (METAL) study were enrolled. The hypertriglyceridemic-waist (HTGW) phenotype was defined as the presence of an elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Read More

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Missed at Birth: A Rare Case of Acute Pancreatitis Secondary to Congenital Diaphragmatic Hernia.

Case Rep Gastrointest Med 2022 16;2022:7580807. Epub 2022 Jun 16.

Franciscan Health Olympia Fields, Department of Gastroenterology, Olympia Fields, IL, USA.

Acute pancreatitis is a common gastrointestinal cause of hospitalizations across the world. The most common etiologies of acute pancreatitis include gallstones, excessive alcohol use, hypertriglyceridemia, or, rarely, trauma. Traction-induced pancreatitis is an uncommon but previously reported cause of acute pancreatitis. Read More

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Dyslipidemia and coronary artery calcium: From association to development of a risk-prediction nomogram.

Nutr Metab Cardiovasc Dis 2022 May 19. Epub 2022 May 19.

Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Big Data Center, China Medical University Hospital and College of Medicine, Taichung, Taiwan. Electronic address:

Background And Aims: The associations between dyslipidemia and coronary artery calcium (CAC) are controversial. We investigated their cross-sectional relationships and developed a predictive scoring system for prognostically significant coronary calcification (PSCC).

Methods And Results: This study evaluated the lipid profiles and the CAC score (CACS) measured through multidetector computed tomography (MDCT) among Taiwanese adult patients in a tertiary hospital between 2011 and 2016. Read More

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Impaired Mitophagy in Sanfilippo A mice Causes Hypertriglyceridemia and Brown Adipose Tissue Activation.

J Biol Chem 2022 Jun 21:102159. Epub 2022 Jun 21.

Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA. Electronic address:

Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase deficiency and heparan sulfate storage on energy homeostasis and metabolism in a mouse model of Type IIIa mucopolysaccharidosis (MPS IIIa, Sanfilippo A syndrome). At 12 weeks of age, MPS IIIa mice exhibited fasting and postprandial hypertriglyceridemia compared to wild-type mice, with a reduction of white and brown adipose tissue depots. Read More

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Risk of Chronic Disease after an Episode of Marasmus, Kwashiorkor or Mixed-Type Severe Acute Malnutrition in the Democratic Republic of Congo: The Lwiro Follow-Up Study.

Nutrients 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2200 Copenhagen, Denmark.

Background: Long-term impact of different forms of severe acute malnutrition (SAM) in childhood on the emergence of noncommunicable diseases (NCDs) is poorly known.

Aim: To explore the association between subtypes of SAM during childhood, NCDs, and cardiovascular risk factors (CVRFs) in young adults 11 to 30 years after post-SAM nutritional rehabilitation.

Methods: In this follow-up study, we investigated 524 adults (mean age 22 years) treated for SAM during childhood in eastern Democratic Republic of the Congo (DRC) between 1988 and 2007. Read More

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A Cross-Sectional Pilot Study on Food Intake Patterns Identified from Very Short FFQ and Metabolic Factors Including Liver Function in Healthy Japanese Adults.

Nutrients 2022 Jun 13;14(12). Epub 2022 Jun 13.

Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, 2-8-1 Mejiro-dai, Bunkyo-ku, Tokyo 112-8681, Japan.

Non-alcoholic fatty liver disease is a growing health problem, and rapid diet assessment is required for personal nutrition education. This pilot study aimed to clarify associations between current food intake patterns identified from the short food frequency questionnaire (FFQ) and metabolic parameters, including liver function. We conducted a cross-sectional study on Japanese non-alcoholic residents of Tokyo and surrounding districts, 20 to 49 years of age. Read More

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Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan.

Colorectal polyps are the precursor lesions of most colorectal cancers. This study aimed to evaluate associations between bone mineral density (BMD), metabolic syndrome (MetS), and gastrointestinal diseases with colorectal polyps in middle-aged and elderly populations. A retrospective cross-sectional study was performed using data from the health examination database of a tertiary medical center in southern Taiwan in 2015. Read More

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A Clinical Case of a Homozygous Deletion in the Gene with Severe Hypertriglyceridemia.

Genes (Basel) 2022 Jun 14;13(6). Epub 2022 Jun 14.

Research Centre for Medical Genetics, Moskvorechye Street, 1, 115522 Moscow, Russia.

Background: Hypertriglyceridemia (HTG) is one of the most common forms of lipid metabolism disorders. The leading clinical manifestations are pancreatitis, atherosclerotic vascular lesions, and the formation of eruptive xanthomas. The most severe type of HTG is primary (or hereditary) hypertriglyceridemia, linked to pathogenic genetic variants in , , and genes. Read More

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A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis.

JCI Insight 2022 Jun 23. Epub 2022 Jun 23.

Department of Diabetes, Endocrinology, and Nutrition (UDEN), Girona Biomedical Research Institute (IDIBGI), Girona, Spain.

The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this, mice lacking the S6k1 gene have a defect in their ability to induce the commitment of fat precursor cells to the adipogenic lineage, which contributes to a significant reduction of fat mass. Here, we assess the therapeutic blockage of S6K1 in diet-induced obese mice challenged with LY2584702 tosylate, a specific oral S6K1 inhibitor initially developed for the treatment of solid tumours. Read More

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Serum Ferritin in Metabolic Syndrome-Mechanisms and Clinical Applications.

Pathophysiology 2022 Jun 17;29(2):319-325. Epub 2022 Jun 17.

Department of Medicine, School of Medical Science and Research, Sharda University, Uttar Pradesh 201306, India.

Metabolic syndrome (MS) is a cluster of conditions including central obesity, hypertriglyceridemia, low HDL cholesterol, hyperglycaemia, and hypertension with a prevalence rate of 20-25% of the world's adult population. Metabolic syndrome is often characterized by insulin resistance, which some have suggested is a major supportive connection between physical inactivity and MS. Various studies suggest that moderately elevated iron and ferritin levels are associated with an increased prevalence of metabolic syndrome and are markers of insulin resistance. Read More

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Metabolome Alterations Linking Sugar-Sweetened Beverage Intake with Dyslipidemia in Youth: The Exploring Perinatal Outcomes among CHildren (EPOCH) Study.

Metabolites 2022 Jun 17;12(6). Epub 2022 Jun 17.

Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.

The objective of this study was to assess intermediary metabolic alterations that link sugar-sweetened beverage (SSB) intake to cardiometabolic (CM) risk factors in youth. A total of 597 participants from the multi-ethnic, longitudinal Exploring Perinatal Outcomes among CHildren (EPOCH) Study were followed in childhood (median 10 yrs) and adolescence (median 16 yrs). We used a multi-step approach: first, mixed models were used to examine the associations of SSB intake in childhood with CM measures across childhood and adolescence, which revealed a positive association between SSB intake and fasting triglycerides (β (95% CI) for the highest vs. Read More

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Metreleptin Treatment in a Boy with Congenital Generalized Lipodystrophy due to Homozygous c.465_468delGACT (p.T156Rfs*8) Mutation in the Gene; The First-year Results.

J Clin Res Pediatr Endocrinol 2022 Jun 23. Epub 2022 Jun 23.

Gazi Yasargil Training and Research Hospital, Pediatric Endocrinology, Diyarbakır, Turkey.

Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by an almost complete absence of body fat. In CGL, patients may have hyperphagia due to leptin deficiency. Recombinant human leptin (metreleptin) has been suggested as an effective treatment option. Read More

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Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis.

Hepatol Commun 2022 Jun 23. Epub 2022 Jun 23.

Gilead Sciences, Foster City, California, USA.

Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl CoA carboxylase (ACC) inhibitors decrease hepatocyte lipotoxicity by inhibiting de novo lipogenesis and concomitantly increasing fatty acid oxidation (FAO), and firsocostat, a liver-targeted inhibitor of ACC1/2, is under evaluation clinically in patients with NASH. ACC inhibition is associated with improvements in indices of NASH and reduced liver triglyceride (TG) content, but also increased circulating TG in subjects with NASH and preclinical rodent models. Read More

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Apheresis Technique for Acute Hyperlipidemic Pancreatitis: A Systemic Review and Meta-Analysis.

Dig Dis Sci 2022 Jun 22. Epub 2022 Jun 22.

Department of Critical Care Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.

Background: The apheresis technique is increasingly used in patients with hypertriglyceridemia-induced pancreatitis (HTGP), while its role in this context is still not well established. Thus, we aimed to evaluate the clinical outcomes of an apheresis therapy compared to usual care in such a patient population.

Methods: We searched PubMed, Embase, and Cochrane library databases up to July 10, 2021. Read More

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The incidence of propofol infusion syndrome in critically-ill patients.

J Crit Care 2022 Jun 17;71:154098. Epub 2022 Jun 17.

New York University Langone Hospital - Long Island, NY, USA.

Purpose: PRIS is a potentially fatal syndrome characterized by various clinical symptoms and abnormalities. Experts suggest that propofol treatment duration ≥48 h or dose ≥83 μg/kg/min is associated with developing PRIS. We hypothesized PRIS might be underdiagnosed due to the overlap of PRIS clinical manifestations with critical illnesses. Read More

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Acute Pancreatitis in Pregnancy: A Ten-Year Noninterventional, Retrospective Cohort Experience.

Gastroenterol Res Pract 2022 9;2022:3663079. Epub 2022 Jun 9.

Department of Gastroenterology, Second Affiliated Hospital of Army Medical University, China.

Background: The study is aimed at evaluating the clinical attributes, types, and risk factors associated with poor outcomes in women with acute pancreatitis (AP) during pregnancy.

Methods: From 2011 to 2020, 45 antenatal mothers with AP were included in this noninterventional, retrospective study. The correlation between etiology of AP, its severity, biochemical parameters, length of stay, and treatment was analyzed. Read More

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Daily Intake of a L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial.

Front Nutr 2022 3;9:890136. Epub 2022 Jun 3.

Research and Graduate Program in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Queretaro, Mexico.

Current efforts to prevent dyslipidemia are focused on the development of functional products as an alternative for hypertriglyceridemia management. This study assessed the metabolic effect of the daily consumption of a bean and oats snack bar (BOSB) on hypertriglyceridemia biomarkers among Mexican women. An 8-weeks randomized parallel clinical trial (ID: NCT0496694, https://clinicaltrials. Read More

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Metabolic dysfunction and obesity-related cancer: Results from the cross-sectional National Health and Nutrition Examination Survey.

Cancer Med 2022 Jun 19. Epub 2022 Jun 19.

Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA.

Background: Metabolic syndrome (MetS), a group of risk factors that define metabolic dysfunction in adults, is strongly associated with obesity and is an emerging risk factor for cancer. However, the association of MetS and degree of metabolic dysfunction with obesity-related cancer is unknown.

Methods: Using National Health and Nutrition Examination Survey data from 1999 to 2018, we identified 528 obesity-related cancer cases and 18,972 cancer-free participants. Read More

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A More Atherogenic Lipoprotein Status Is Present in Adults With Than Without Type 2 Diabetes Mellitus With Equivalent Degrees of Hypertriglyceridemia.

Can J Diabetes 2022 Feb 9. Epub 2022 Feb 9.

Division of Endocrinology and Metabolism, Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address:

Objectives: The impact of type 2 diabetes (T2DM) on biomarkers denoting lipoprotein compositional status was studied in mild and moderate hypertriglyceridemia (HTG). Diabetic dyslipidemia pathophysiology could contribute to differences in lipoprotein compositional status, which could be reflected in the preferred cardiovascular disease risk prediction markers in HTG: non-high-density lipoprotein cholesterol (non-HDLC) and apolipoprotein B (apoB).

Methods: 2,775 fasting lipid profiles from a tertiary-care lipid clinic were analyzed as 2 subgroups (with and without T2DM), stratified by triglyceride (TG) levels: normotriglyceridemia (TG 0. Read More

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February 2022

Circulating microparticles as indicators of cardiometabolic risk in PCOS.

Clin Chim Acta 2022 Jun 17;533:63-70. Epub 2022 Jun 17.

Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Polycystic ovary syndrome (PCOS), the most prevalent endocrine disturbance of the female reproductive system, is associated with several pathologic conditions, such as metabolic syndrome, obesity, diabetes, dyslipidemia, and insulin resistance, all of which are tightly connected to its progression. These factors are associated with a type of extracellular vesicle, ie, microparticles (MPs), released by shedding due to cell activation and apoptosis. Circulating MPs (cMPs) are secreted by a variety of cells, such as platelets, endothelial, leukocytes, and erythrocytes, and contain cytoplasmic substances derived from parent cells that account for their biologic activity. Read More

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Increased prevalence of depression and anxiety among subjects with metabolic syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

J Acad Consult Liaison Psychiatry 2022 Jun 16. Epub 2022 Jun 16.

Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo, São Paulo; Department of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Metabolic syndrome (MetS) and common mental disorders are prevalent conditions. However, the relationship between MetS and its components with depression, anxiety, and common mental disorders has not been sufficiently addressed in low-/middle- income countries.

Objective: To investigate whether depression, anxiety, and common mental disorders are associated with MetS and its components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Read More

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Normal fasting triglyceride levels and incident type 2 diabetes in the general population.

Cardiovasc Diabetol 2022 Jun 18;21(1):111. Epub 2022 Jun 18.

Division of Clinical Chemistry, Department of Laboratory Medicine (LABMED), Karolinska Institutet, H5, Alfred Nobels Alle 8, S-141 83, Stockholm, Sweden.

Background: Type 2 diabetes is increasing worldwide. Traditionally, only hypertriglyceridemia is considered a risk factor. We investigated whether also normal triglycerides prospectively associate with incident type 2 diabetes in healthy subjects. Read More

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Acute coronary syndrome after liver transplantation in a young primary biliary cholangitis recipient with dyslipidemia: a case report.

Surg Case Rep 2022 Jun 17;8(1):113. Epub 2022 Jun 17.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Primary biliary cholangitis (PBC) is a chronic, progressive liver disease associated with dyslipidemia. There is a consensus that PBC does not accelerate coronary artery disease despite high cholesterol levels, so the screening test for the coronary artery is not routinely performed before liver transplantation (LT). To date, no report has described the potential risk of PBC-related dyslipidemia for developing acute coronary syndrome (ACS) after LT. Read More

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