16,570 results match your criteria Hypertriglyceridemia

Sequential everolimus for angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study.

Orphanet J Rare Dis 2021 Jun 14;16(1):277. Epub 2021 Jun 14.

Department of Urology, the Third Medical Centre, Chinese PLA General Hospital, 69 Yong Ding Road, Beijing, 100039, China.

Background: To evaluate the efficacy, safety and health economics of sequential everolimus in treating angiomyolipoma (AML) associated with tuberous sclerosis complex (TSC).

Methods: In this prospective cohort study, patients met the inclusion criteria received standard or sequential treatment according to their willingness. All patients received an initial dose of everolimus (10 mg oral, once a day) for 3 months. Read More

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Stressful life events and serum triglyceride level: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort.

Epidemiol Health 2021 Jun 9:e2021042. Epub 2021 Jun 9.

Department of Public Health, Graduate School, Yonsei University, Seoul, South Korea.

Background: An elevated serum triglyceride level is a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on the serum triglyceride levels among the healthy population. Read More

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Association between hyperuricemia and metabolic risk components in Korean women.

Health Care Women Int 2021 Jun 14:1-11. Epub 2021 Jun 14.

College of Nursing, Gachon University, Incheon, Korea.

The researchers evaluated the association between hyperuricemia and metabolic risk components in Korean women of reproductive and postmenopausal ages. The study data were collected from the Korea National Health and Nutrition Examination Survey 2016. Among a total of 4305 female participants, the data of 2958 women were analyzed. Read More

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A Fatal Case of Hypertriglyceridemia-Induced Acute Pancreatitis in a Patient With Diabetic Ketoacidosis.

Cureus 2021 May 11;13(5):e14968. Epub 2021 May 11.

Pulmonary and Critical Care, Richmond University Medical Center, Staten Island, USA.

Diabetic ketoacidosis (DKA) with coexisting hypertriglyceridemia-induced acute pancreatitis is a rare yet potentially life-threatening condition. This report describes a patient with no history of diabetes who presented with DKA and coexisting acute pancreatitis secondary to severe hypertriglyceridemia. The patient did not respond to standard DKA management or plasmapheresis, developed acute respiratory distress syndrome (ARDS), and eventually expired. Read More

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Four New Cases of SLC35A2-CDG With Novel Mutations and Clinical Features.

Front Genet 2021 27;12:658786. Epub 2021 May 27.

Department of Hepatology, Children's Hospital of Fudan University, Shanghai, China.

SLC35A2-CDG is a rare type of X-linked CDG with more than 60 reported cases. We retrospectively analyzed clinical phenotypes and genotypes of four cases of SLC35A2-CDG from four unrelated families of Han ethnicity in China. All patients had infantile onset epilepsies that were completely or partly resistant to multiple anti-epileptic medications or ketogenic diet. Read More

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Association of Dynamic Changes in Metabolic Syndrome Status with the Risk of Parkinson's Disease: A Nationwide Cohort Study.

J Parkinsons Dis 2021 Jun 10. Epub 2021 Jun 10.

Department of Medical Lifescience, College of Medicine, The catholic University of Korea, Seoul, Republic of Korea.

Background: The longitudinal association between dynamic changes in the metabolic syndrome (MS) status and Parkinson's disease (PD) has been poorly studied.

Objective: We examined whether dynamic changes in MS status are associated with altered risk for PD.

Methods: This study was a nationwide retrospective cohort study. Read More

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Agomelatine reduces circulating triacylglycerides and hepatic steatosis in fructose-treated rats.

Biomed Pharmacother 2021 Jun 11;141:111807. Epub 2021 Jun 11.

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 105 Alexander Flemming St., Zip Code: 13083-881, Campinas, SP, Brazil. Electronic address:

Agomelatine (AGO) is an antidepressant drug with agonistic activity at melatonin receptor 1 (MT1) and MT2 and with neutral antagonistic activity at serotonin receptor 5-HT2. Although experimental studies show that melatonin reduces hypertriglyceridemia and hepatic steatosis induced by excessive fructose intake, no studies have tested if AGO exerts similar actions. To address this issue we have treated male Wistar rats with fructose (15% in the drinking water) and/or AGO (40 mg/kg/day) for two weeks. Read More

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A rare case of diabetic ketoacidosis presenting with severe hypertriglyceridemia requiring plasmapheresis in an adult with type-2 diabetes mellitus: Case report.

Medicine (Baltimore) 2021 Jun;100(23):e26237

Internal Medicine Residency Program, UPMC Pinnacle Harrisburg Hospital.

Introduction: Severe hypertriglyceridemia (HTG) is a rare complication of insulin resistance. Its presentation with diabetic ketoacidosis (DKA) has been reported in a few cases, where most patients have type-1 diabetes mellitus (DM). Our case represents a unique presentation of DKA associated with severe HTG above 10,000 mg/dL in an adult with type-2 DM. Read More

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Peroxisome proliferator-activated receptor agonist (pioglitazone) with exogenous adiponectin ameliorates arterial stiffness and oxidative stress in diabetic Wistar Kyoto rats.

Eur J Pharmacol 2021 Jun 7:174218. Epub 2021 Jun 7.

School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia; Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

Oxidative stress causes hypoadiponectemia and reactive oxygen species production. This study investigates the pathophysiological role and potential effects of adiponectin with partial and full peroxisome proliferator-activated receptor-gamma agonists on modulation of metabolic dysregulation and oxidative stress in diabetic model of Wistar Kyoto rats (WKY). Forty two male WKY rats were randomized equally into 7 groups (n=6), Group I serve as control, group II as WKY diabetic control, groups III, IV and V treated with irbesartan (30mg/kg), pioglitazone (10mg/kg) and adiponectin (2. Read More

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Triglyceride-Rich Lipoproteins, Apolipoproteins, and Atherosclerotic Cardiovascular Events Among Patients with Diabetes Mellitus and End-Stage Renal Disease on Hemodialysis.

Am J Cardiol 2021 Jun 6. Epub 2021 Jun 6.

Kidney Research Institute, University of Washington, Seattle, Washington.

Hypertriglyceridemia may be implicated in the high atherosclerotic cardiovascular disease (ASCVD) risk experienced by patients with end-stage renal disease (ESRD). In this post-hoc analysis of the "Die Deutsche Diabetes Dialyse Studie (4D)" clinical trial, we examined incident ASCVD events, defined as myocardial infarction, ischemic stroke, or a coronary revascularization procedure, among 1255 participants with type 2 diabetes and ESRD treated with hemodialysis. Cox-regression methods were used to evaluate the association of triglycerides, very-low density lipoprotein cholesterol (VLDL-C), and apolipoproteins B (Apo B) and C-III (Apo C-III) with ASCVD. Read More

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A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time.

BMC Endocr Disord 2021 Jun 9;21(1):115. Epub 2021 Jun 9.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

Background: Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. Read More

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[Sucecesfull bone marrow transplantation in a case of familial hemophagocytic lymphohistiocytosis type 3].

Andes Pediatr 2021 Apr;92(2):269-273

Centro de Investigaciones en Anomalías Congénitas y enfermedades Raras, Universidad ICEsI, Cali, Colombia.

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an exaggerated activation of the immune system which can be either primary (familial) or secondary. Familial hemophagocytic lymphohistiocytosis type 3 (FHL-3) is a severe immune disorder, caused by mutations in the UNC13D gene, which codes for a protein crucial to the cytotoxic function of lymphocytes.

Objective: To describe the diagnostic relevance of next-generation sequencing in the approach of a patient with suspected FHL and to demonstrate the effectiveness of bone marrow transplantation as the only curative measure. Read More

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Validation by HPLC analyses of new equations for estimating cholesterol in plasma lipoprotein subfractions.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jun 5;1866(9):158986. Epub 2021 Jun 5.

Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.

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Lipids and peripheral neuropathy.

Curr Opin Lipidol 2021 Jun 7. Epub 2021 Jun 7.

Faculty of Biology, Medicine and Health, University of Manchester Department of Endocrinology, Diabetes and Metabolism, Peter Mount Building, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK Department of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK Weill-Cornell Medicine-Qatar, Doha, Qatar.

Purpose Of Review: Hyperlipidaemia is associated with the development of neuropathy. Indeed, a mechanistic link between altered lipid metabolism and peripheral nerve dysfunction has been demonstrated in a number of experimental and clinical studies. Furthermore, post hoc analyses of clinical trials of cholesterol and triglyceride-lowering pharmacotherapy have shown reduced rates of progression of diabetic neuropathy. Read More

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Predictors of same-admission cholecystectomy in mild, acute, biliary pancreatitis.

HPB (Oxford) 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgery, Saint Agnes Healthcare, Baltimore, MD, USA.

Background: Failure to perform same-admission cholecystectomy (SA-CCY) for mild, acute, biliary pancreatitis (MABP) is a recognized risk factor for recurrence and readmission. However, rates of SA-CCY are low and factors associated with these low rates require elucidation.

Methods: Primary MAPB admissions were pooled from NIS 2000-2014 (weighted n = 578 258). Read More

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Efficacy of a micronized, nanocrystal fenofibrate formulation in treatment of hyperlipidemia in dogs.

J Vet Intern Med 2021 Jun 6. Epub 2021 Jun 6.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, 1 Shields Ave., Davis, California 95616, USA.

Background: Safe, effective, and readily available drug therapies are required for the management of hyperlipidemia and its associated complications in dogs.

Objectives: To investigate the efficacy of a micronized, nanocrystal formulation of fenofibrate (Tricor) in the treatment of hyperlipidemia in dogs.

Animals: Ten client-owned dogs with primary (n = 7) and secondary (n = 3) hyperlipidemia. Read More

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Treatment of Severe Hypertriglyceridemia During Pregnancy With High Doses of Omega-3 Fatty Acid and Plasmapheresis.

AACE Clin Case Rep 2021 May-Jun;7(3):211-215. Epub 2021 Jan 27.

Division of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Objective: Severe hypertriglyceridemia carries increased health risks, including the development of pancreatitis. The objective of this study was to report on management of 2 cases with severe gestational hypertriglyceridemia.

Cases: In case 1, a 33-year-old pregnant woman presented with serum triglyceride level of 14 000 mg/dL after discontinuing hypolipidemic medications. Read More

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January 2021

Associations Between Single-Child Status and Metabolic Syndrome in Children and Adolescents in China.

Front Pediatr 2021 20;9:661164. Epub 2021 May 20.

Menzies Health Institute Queensland, Griffith University, Brisbane, QLD, Australia.

To evaluate the associations between single-child status and metabolic syndrome (MS) and to identify the highest risk group of MS among single children. Differences in participants' characteristics by sex were examined by Student's -test for continuous variables and Pearson's chi-squared test for categorical variables. Multivariate logistic regression analysis was performed to estimate the odds ratios () and 95% confidence intervals () for MS and its components according to the single-child status. Read More

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Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study.

J Clin Hypertens (Greenwich) 2021 Jun 6. Epub 2021 Jun 6.

Department of Cardiovascular Medicine, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n = 2423) were hypertensive and diabetic patients enrolled in a China nationwide registry. Read More

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Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.

Mol Metab 2021 Jun 3:101265. Epub 2021 Jun 3.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Objective: Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims to prevent hypoglycemia, patients still experience hypoglycemic events. Read More

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Gender difference in metabolic syndrome and incident colorectal adenoma: A prospective observational study (KCIS No.42).

Medicine (Baltimore) 2021 Jun;100(22):e26121

Department of Family Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Abstract: This community-based study aimed to elucidate whether there is a gender difference in the effect of metabolic syndrome (MetS) and its individual components on an elevated risk for incident colorectal adenoma.A prospective cohort study was conducted by enrolling 59,767 subjects aged 40 years or older between 2001 and 2009 in Keelung, Taiwan, to test this hypothesis, excluding those with a prior history of colorectal cancer and those with colorectal cancer diagnosed at the first screening. Cox proportional hazards regression models were used to assess the effect of MetS in terms of a dichotomous classification, each individual component and the number of components for males and females. Read More

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Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study.

Int J Lab Hematol 2021 Jun 4. Epub 2021 Jun 4.

Department of Internal Medicine, King George's Medical University, Lucknow, India.

Introduction: The clinical and laboratory features of severe COVID-19 infection overlap with those of hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory disorder often associated with several viral infections. The clinical syndrome of HLH encompasses fever, organomegaly, cytopenias, hyperferritinemia, hypertriglyceridemia, raised transaminases, hypofibrinogenemia, absent natural killer (NK) cell activity, increased soluble CD25 and hemophagocytic lymphohistiocytosis in bone marrow, spleen, and lymph nodes.

Methods: We analyzed clinicopathological and laboratory features of thirteen patients with severe COVID-19 infection suspected to have HLH and found to have hemophagocytic histiocytosis on bone marrow examination (BME). Read More

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Metabolic complications in myotonic dystrophy type 1: A cross-sectional survey using the National Registry of Japan.

J Neurol Sci 2021 May 27;427:117511. Epub 2021 May 27.

Department of Neurology, National Hospital Organization Aomori National Hospital, Namioka, Aomori 038-1331, Japan. Electronic address:

Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults, affecting multiple organs, including the eyes, heart, endocrine system, and central nervous system. The broad spectrum of DM1 symptoms has been attributed to the aberrant pre-mRNA splicing of various genes due to an abnormal expansion of the CTG repeat in the 3' untranslated region of the DMPK gene. The current challenge in the clinical care of DM1 is the lack of well-established protocols for the management of each organ disorder or symptom. Read More

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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore.

PLoS One 2021 2;16(6):e0252320. Epub 2021 Jun 2.

Department of Infectious Diseases, National Centre for Infectious Diseases, Singapore.

Background: While the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore.

Methods: We conducted a retrospective study using the clinical database maintained by the Clinical HIV Programme at the National Centre for Infectious Diseases, Singapore. Read More

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Association between the Use of Health Services, Cardiovascular Risk Factors and Metabolic Syndrome in Mexican Adults.

Int J Environ Res Public Health 2021 May 17;18(10). Epub 2021 May 17.

Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS & IDISBA, 07122 Palma de Mallorca, Spain.

: The use of health services is a complex behavioral phenomenon affected by multiple factors (availability, distance, cost, quality, attitudes, cultural beliefs, socioeconomic characteristics, and individuals' self-perception of health). Mexico has a segmented health system, and the access to it depends on the labor insertion and the population's ability to pay. : To assess association between use of health services and cardiovascular and metabolic syndrome risk factors among Mexican adults. Read More

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Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review.

Nutrients 2021 May 22;13(6). Epub 2021 May 22.

Internal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

While targeting elevated serum levels of low-density lipoprotein cholesterol has been the mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding the atherogenic role of hypertriglyceridemia is still controversial. Various epidemiological population-based studies on statin-treated subjects nominated triglycerides, triglyceride-rich lipoproteins (namely, chylomicrons and very-low-density lipoprotein particles), and their remnants as major determinants of the substantial residual cardiovascular risk. With the triglyceride-glucose index and triglyceride to high-density lipoprotein ratio emerging as surrogate indicators of peripheral artery disease and atherosclerotic cerebrovascular disease, one can conclude that further research addressing the intricate relationship between triglycerides and atherosclerosis is warranted. Read More

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Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis.

Biomolecules 2021 May 6;11(5). Epub 2021 May 6.

Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. Read More

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Asymptomatic Carotid Atherosclerosis Cardiovascular Risk Factors and Common Hypertriglyceridemia Genetic Variants in Patients with Systemic Erythematosus Lupus.

J Clin Med 2021 May 20;10(10). Epub 2021 May 20.

Cardiovascular Risk Unit-Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

SLE is associated with increased cardiovascular risk. The objective of this study was to determine the prevalence of asymptomatic carotid atherosclerosis to analyze its relationship with dyslipidemia and related genetic factors in a population of patients with SLE. Seventy-one SLE female patients were recruited. Read More

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Development of Metabolic Syndrome Decreases Bone Mineral Density T-Score of Calcaneus in Foot in a Large Taiwanese Population Follow-Up Study.

J Pers Med 2021 May 20;11(5). Epub 2021 May 20.

Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Studies have suggested that there may be common pathogenic pathways linking osteoporosis and metabolic syndrome (MetS) due to the multiple risk factors for atherosclerotic cardiovascular disease caused by MetS. However, results on the association between MetS and bone health are inconsistent and sometimes contradictory. In this study, we aimed to investigate the associations between the effects of MetS risk factors and bone mineral density (BMD) T-score in a longitudinal study of 27,033 participants from the Taiwan Biobank with a follow-up period of 4 years. Read More

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Postprandial Lipid Metabolism in Normolipidemic Subjects and Patients with Mild to Moderate Hypertriglyceridemia: Effects of Test Meals Containing Saturated Fatty Acids, Mono-Unsaturated Fatty Acids, or Medium-Chain Fatty Acids.

Nutrients 2021 May 20;13(5). Epub 2021 May 20.

Department of Internal Medicine 4, Ludwig-Maximilians University Munich, 81377 Munich, Germany.

Fasting and postprandial hypertriglyceridemia are causal risk factors for atherosclerosis. The prevalence of hypertriglyceridemia is approximately 25-30% and most hypertriglyceridemic patients suffer from mild to moderate hypertriglyceridemia. Data regarding dietary interventions on postprandial triglyceride metabolism of mildly to moderately hypertriglyceridemic patients is, however, sparse. Read More

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