14,977 results match your criteria Hypertriglyceridemia


Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats.

Oxid Med Cell Longev 2019 21;2019:9417498. Epub 2019 Mar 21.

Laboratory of Experimental Physiology (LeFisio), Department of Physiological Sciences, Federal University of Maranhão, Av. dos Portugueses, 1966-Cidade Universitária Dom Delgado, São Luís, MA 65080-805, Brazil.

is used worldwide for the treatment of metabolic syndrome-associated outcomes. Previously, we described the antihypertriglyceridemic effect of the hydroethanolic extract of leaf (HESc) in monosodium L-glutamate- (MSG-) induced obese rats. This study sought to investigate the molecular mechanisms underlying the antihypertriglyceridemic effect of HESc in MSG-obese rats. Read More

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http://dx.doi.org/10.1155/2019/9417498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446099PMC

Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6.

Diab Vasc Dis Res 2019 Mar;16(2):144-152

1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Reaven originally described the clustering of insulin resistance/hyperinsulinaemia, obesity (particularly visceral), altered cytokine levels, glucose intolerance, hypertriglyceridaemia and low high-density lipoprotein cholesterol. Subsequently, a potentially highly atherogenic small, dense low-density lipoprotein was also reported. We have studied the effect of bariatric surgery on this and other risk factors for atherosclerosis. Read More

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http://dx.doi.org/10.1177/1479164119826479DOI Listing

Impact of race/ethnicity on insulin resistance and hypertriglyceridaemia.

Diab Vasc Dis Res 2019 Mar;16(2):153-159

1 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Objective: Insulin sensitivity affects plasma triglyceride concentration and both differ by race/ethnicity. The purpose of this study was to provide a comprehensive assessment of the variation in insulin sensitivity and its relationship to hypertriglyceridaemia between five race/ethnic groups.

Research Design And Methods: In this cross-sectional study, clinical data for 1025 healthy non-Hispanic White, Hispanic White, East Asian, South Asian and African American individuals were analysed. Read More

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http://dx.doi.org/10.1177/1479164118813890DOI Listing

EXTERNAL VALIDATION OF A PREDICTIVE MODEL FOR ACUTE PANCREATITIS RISK IN PATIENTS WITH SEVERE HYPERTRIGLYCERIDEMIA.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Division of Endocrinology and Diabetes, John H. Stroger, Jr. Hospital of Cook County, and Rush University Medical Center, Chicago, IL.

We previously developed a predictive model to assess the risk of developing acute pancreatitis (AP) in patients with severe hypertriglyceridemia (HTG). In this study, we aimed to externally validate this model. The validation cohort included cross-sectional data between 2013 and 2017. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0599
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http://dx.doi.org/10.4158/EP-2018-0599DOI Listing
April 2019
1 Read

ATP-binding cassette sub-family a member1 gene mutation improves lipid metabolic abnormalities in diabetes mellitus.

Lipids Health Dis 2019 Apr 22;18(1):103. Epub 2019 Apr 22.

Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Background: Patients with diabetes mellitus were often accompanied with hyperlipidemia. ATP-binding cassette sub-family A member1 (ABCA1) promotes the efflux of lipids and thereby mediates the metabolism of cholesterol. The aim of our study was to determine the associations of ABCA1 gene polymorphisms with the risks of diabetes mellitus and dyslipidemia in diabetic patients. Read More

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http://dx.doi.org/10.1186/s12944-019-0998-3DOI Listing

Long-Term Comparison of Ethyl Icosapentate vs. Omega-3-Acid Ethyl in Patients With Cardiovascular Disease and Hypertriglyceridemia (DEFAT Trial).

Circ J 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiovascular Surgery, Nihon University School of Medicine.

Background: Numerous studies have demonstrated a reduction in cardiovascular events when the low-density lipoprotein cholesterol (LDL) level is decreased by statin therapy. However, despite good control of LDL, cardiovascular events may increase if the triglyceride (TG) level is high. We conducted a long-term comparison of treatment of hypertriglyceridemia with ethyl icosapentate (EPA) vs. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-0764DOI Listing

An updated review of lipid-modifying therapy.

Authors:
Leon A Simons

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

UNSW Sydney, Sydney, NSW.

Statin drugs reduce low-density lipoprotein (LDL)-cholesterol (LDL-C) and cardiovascular risk. Ezetimibe may be used to supplement statin therapy, or used alone in cases of statin intolerance. Statin-associated side effects do occur, especially muscle symptoms and new onset diabetes, but they do not detract from the benefits of statin therapy. Read More

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http://dx.doi.org/10.5694/mja2.50142DOI Listing

Familial chylomicronemia syndrome: A rare but devastating autosomal recessive disorder characterized by refractory hypertriglyceridemia and recurrent pancreatitis.

Trends Cardiovasc Med 2019 Mar 19. Epub 2019 Mar 19.

Division of Cardiology, Advocate Heart Institute at Advocate Lutheran General, Hospital, 1775 Dempster St., Parkside B-01, Park Ridge, IL 60068, USA. Electronic address:

Familial Chylomicronemia Syndrome (FCS) is a rare autosomal recessive lipid disorder characterized by severe hypertriglyceridemia and recurrent pancreatitis. Because the disorder is often misdiagnosed or not diagnosed and because traditional triglyceride lowering medications are often ineffective, the disease leads to a tremendous physical, social and emotional burden on afflicted patients and their caretakers. Mutations in 5 different genes have been implicated in the development of FCS, all of which have an effect on the activity of lipoprotein lipase. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10501738193003
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http://dx.doi.org/10.1016/j.tcm.2019.03.001DOI Listing
March 2019
1 Read

Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats.

Environ Pollut 2019 Apr 9;250:312-322. Epub 2019 Apr 9.

Laboratory of Endocrine Physiology, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, RJ, Brazil. Electronic address:

Bisphenol S (BPS) has replaced bisphenol A (BPA), a known non-persistent endocrine disrupting chemical, in several products. Considering that little is known regarding BPS effects, especially during critical windows of ontogenetic development, and that BPA, which is quite similar to BPS, is know to be transferred to the offspring via the placenta and milk, in the present study we investigated the behavioral, biochemical and endocrine profiles of Wistar rats born from dams that were BPS-exposed [groups: BPS10 (10 μg/kg/day), BPS50 (50 μg/kg/day)] during pregnancy and lactation. Due to the non-monotonic dose-response effect of bisphenol, the data of both BPS groups were directly compared with those of the controls, not to each other. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.100DOI Listing

Abnormality of hepatic triglyceride metabolism in Apc mice with colon cancer cachexia.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, No.5333 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. Electronic address:

Aims: Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of Apc mice.

Main Methods: We measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and Apc mice. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.041DOI Listing

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
1 Read

The effect of high fat dietary modification and nutritional status on the outcome of critically ill ventilated children: Single-center study.

Korean J Pediatr 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Purpose: We aimed to assess the effect of high fat dietary modification and nutritional status on ventilatory and final outcomes of pediatric intensive care.

Methods: Fifty-one ventilated children (1 month to 12 years) with pulmonary disease who could be enterally fed; in Cairo University Pediatric intensive care unit, were divided into two groups. Group A: included 25 patients who received isocaloric high fat low carbohydrates diet. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.06835
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http://dx.doi.org/10.3345/kjp.2018.06835DOI Listing
April 2019
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Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.

Hepatology 2019 Apr 15. Epub 2019 Apr 15.

Maternal and Fetal Disease Group, Women and Children's Health Division, King's College London, London, SE1 1UL, UK.

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metabolic activity. We sought to identify whether enteric endocrine signals contribute to raised serum bile acids observed in human and murine pregnancies, by measuring fibroblast growth factor (FGF)19/15 protein and mRNA levels, and 7α-hydroxy-4-cholesten-3-one. Read More

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http://dx.doi.org/10.1002/hep.30661DOI Listing

Large triglyceride-rich lipoproteins from fasting patients with type 2 diabetes activate platelets.

Diabetes Metab 2019 Apr 11. Epub 2019 Apr 11.

Université-Lyon, CarMeN Laboratory, Inserm U1060, INRA U1397, INSA Lyon, université Claude-Bernard Lyon 1, IMBL, 69621 Villeurbanne, France. Electronic address:

Aims: Type 2 diabetes (T2D) patients present with risk factors for atherothrombosis such as fasting hypertriglyceridaemia and platelet hyperactivity. Our study objective was to determine the effect of large triglyceride-rich lipoproteins (TGRL) from fasting T2D patients on platelet aggregation and, if any, to identify the signaling pathway involved.

Methods: Large TGRL were isolated from the plasma of 25 T2D patients by ultracentrifugation (density < 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12623636193005
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http://dx.doi.org/10.1016/j.diabet.2019.03.002DOI Listing
April 2019
1 Read

Cystic fibrosis dyslipidaemia: A cross-sectional study.

J Cyst Fibros 2019 Apr 9. Epub 2019 Apr 9.

Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland. Electronic address:

Background: The interest in cystic fibrosis (CF) dyslipidaemia as a potential risk factor for cardiovascular disease is increasing with patients' survival. This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE).

Methods: This cross-sectional study assessed clinical characteristics of CF, as well as the serum lipid profile, oxLDL, adiponectin, and APOE. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.001DOI Listing
April 2019
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Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.

J Am Soc Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan;

Background: A family history of urolithiasis is associated with a more than doubling of urolithiasis risk, and a twin study estimating 56% heritability of the condition suggests a pivotal role for host genetic factors. However, previous genome-wide association studies (GWAS) have identified only six risk-related loci.

Methods: To identify novel urolithiasis-related loci in the Japanese population, we performed a large-scale GWAS of 11,130 cases and 187,639 controls, followed by a replication analysis of 2289 cases and 3817 controls. Read More

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http://dx.doi.org/10.1681/ASN.2018090942DOI Listing
April 2019
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Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: the Korean Urban Rural Elderly cohort study.

BMC Geriatr 2019 Apr 11;19(1):102. Epub 2019 Apr 11.

Division of Geriatrics, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03772, Republic of Korea.

Background: Many studies have investigated the association between vitamin D and metabolic syndrome (MetS). However, few studies have investigated the association stratified by sex in the elderly. Therefore, we aimed to evaluate the association between vitamin D, MetS, and its components in Korean elderly men and women. Read More

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http://dx.doi.org/10.1186/s12877-019-1118-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458686PMC
April 2019
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Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism.

PLoS One 2019 11;14(4):e0215246. Epub 2019 Apr 11.

Department of Food Science and Dietetics, Wroclaw Medical University, Wroclaw, Poland.

In lung cancer (LC), alterations in redox balance are extensively observed and are a consequence of disease as well as co-occurrent with smoking. We previously demonstrated that metabolic disturbances such as trace element status and carbohydrate metabolism alterations are linked with redox status. The aim of this study was to evaluate relationships between the serum parameters of lipid metabolism and redox balance in LC patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215246PLOS
April 2019
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Role of apolipoprotein C-III overproduction in diabetic dyslipidemia.

Diabetes Obes Metab 2019 Apr 10. Epub 2019 Apr 10.

Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden.

Aims: ApoC-III is an important novel target underpinning the link between hypertriglyceridemia with cardiovascular disease. Here, we investigated how apoC-III metabolism is altered in subjects with type 2 diabetes, and focused on whether the perturbed plasma triglyceride concentrations in this condition are determined primarily by the secretion rate or the removal rate of this apoprotein. Second, we investigated whether improvement of glycemic control using the GLP-1 analogue liraglutide for 16 weeks modifies apoC-III dynamics. Read More

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http://dx.doi.org/10.1111/dom.13744DOI Listing
April 2019
3 Reads

Refeeding Syndrome as a Possible Cause of Very Early Mortality in Acute Pancreatitis.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background/aims: : The incidence and cause of early mortality in acute pancreatitis (AP) arenot fully understood. Refeeding syndrome (RFS) is a fatal clinical complication that can occuras a result of fluid and electrolyte shifts during early nutritional rehabilitation for malnourishedpatients. This study was conducted to determine the clinical implications of RFS in patientswith AP. Read More

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http://dx.doi.org/10.5009/gnl18458DOI Listing
February 2019
3 Reads

Molecular targets of fenofibrate in the cardiovascular-renal axis: A unifying perspective of its pleiotropic benefits.

Pharmacol Res 2019 Apr 7;144:132-141. Epub 2019 Apr 7.

Periyar Maniammai Institute of Science & Technology (Deemed to be University), Vallam, 613403, India.

The activation of peroxisome proliferator-activated receptor α (PPARα) is a key pharmacological drug target for dyslipidemic management. Dyslipidemia is associated with abnormal serum lipid profiles viz. elevated total cholesterol, high triglyceride, elevated low-density lipoprotein cholesterol, and reduced high-density lipoprotein cholesterol levels. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.025DOI Listing
April 2019
1 Read

Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: a Review.

Curr Drug Targets 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur. Malaysia.

Metabolic syndrome (MetS) involves a cluster of five conditions, i.e. obesity, hyperglycaemia, hypertension, hypertriglyceridemia and low high-density lipoprotein (HDL) cholesterol. Read More

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http://dx.doi.org/10.2174/1389450120666190405172524DOI Listing

Severe hypertriglyceridemia associated with everolimus drug-eluting stent placement in an infant.

Cardiol Young 2019 Apr 8:1-3. Epub 2019 Apr 8.

Division of Neonatology,Children's Hospital of Philadelphia,Philadelphia, PA,USA.

We report a case of severe hypertriglyceridemia associated with an everolimus drug-eluting stent in an infant with pulmonary vein stenosis. We review from current literature the mechanisms by which everolimus may cause dyslipidaemia, pharmacokinetics of everolimus in drug-eluting stents, and treatments of hypertriglyceridemia. This case demonstrates the need to closely monitor serum triglyceride levels after everolimus drug-eluting stent placement in infants. Read More

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http://dx.doi.org/10.1017/S1047951119000167DOI Listing
April 2019
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High-Fat Diet Elevates Liver Docosahexaenoic Acid Possibly through Over-Expression of Very Long-Chain Fatty Acid Elongase 2 in C57BL/6J Mice.

Int J Vitam Nutr Res 2019 Apr 8:1-11. Epub 2019 Apr 8.

1 Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, India.

The liver is the main site of lipid metabolism and vitamin A storage. Dietary factors are known to affect liver function, thereby leading to metabolic abnormalities. Here, we assessed the impact of long-term feeding of a high-fat diet on hepatic vitamin A status and lipid metabolism. Read More

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http://dx.doi.org/10.1024/0300-9831/a000432DOI Listing

Lipid profile and renal safety of tenofovir disoproxil fumarate-based anti-retroviral therapy in HIV-infected Chinese patients.

Int J Infect Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Infectious and Immune Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai, China; Department of Internal Medicine, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Background: Tenofovir disoproxil fumarate (TDF) is an important component of antiretroviral therapy (ART) that has been widely used. The aim of this study was to observe the long-term impact of TDF-based ART on lipid metabolism profiles and renal functions in Chinese patients.

Methods: 414 and 124 HIV-infected, ART-naïve patients who initiated TDF-based regimens and non-TDF regimens respectively were retrospectively included. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.03.034DOI Listing
April 2019
1 Read

Muscle relaxant induced pancreatitis leading to hyperosmolar hyperglycemic state.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz012. Epub 2019 Mar 29.

Little Rock Diagnostic Clinic, CHI St. Vincent, Little Rock, USA.

Muscle relaxants are commonly prescribed in the United States but may have deleterious side effects that are unrecognized by physicians. Here, we report a 55-year-old Caucasian man who developed pancreatitis and a subsequent hyperosmolar hyperglycemic state after being prescribed tizanidine. The patient had untreated hypertriglyceridemia, unbeknownst to the prescribing physician. Read More

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http://dx.doi.org/10.1093/omcr/omz012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440256PMC
March 2019
1 Read

Severe hypertriglyceridaemia and pancreatitis in a patient with lipoprotein lipase deficiency based on mutations in lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) genes.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands.

A 44-year-old woman was admitted with pancreatitis caused by hypertriglyceridaemia (fasting triglycerides 28 mmol/L). She used oral contraceptives and ezetimibe 10 mg. She was overweight (body mass index 29. Read More

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http://dx.doi.org/10.1136/bcr-2018-228199DOI Listing
April 2019
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Metabolic impairments in patients with myotonic dystrophy type 2.

Acta Myol 2018 Dec 1;37(4):252-256. Epub 2018 Dec 1.

Neurology Clinic, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbia.

Objectives: metabolic syndrome (MetS) increases risk of cardiovascular diseases and diabetes mellitus type 2. Aim of this study was to investigate frequency and features of MetS in a large cohort of patients with DM2.

Materials & Methods: this cross-sectional study included 47 DM2 patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416699PMC
December 2018
4 Reads

The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa.

Int J Pediatr 2019 3;2019:7013758. Epub 2019 Mar 3.

Division of Cardiology and Infectious Diseases, Department of Pediatrics, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

Background: Despite the high prevalence of the HIV/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population.

Methods: A cross-sectional study was completed in Kinshasa, the Democratic Republic of Congo. Read More

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https://www.hindawi.com/journals/ijpedi/2019/7013758/
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http://dx.doi.org/10.1155/2019/7013758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420969PMC
March 2019
6 Reads

Hypertriglyceridaemia predicts the subsequent long-term risk of cardiovascular events in Chinese adults: Results from a 23-year follow-up of the Daqing Diabetes Study.

Diabetes Metab Res Rev 2019 Apr 2:e3163. Epub 2019 Apr 2.

Center of Endocrinology and Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Xicheng District, Beijing, China.

Background: Limited information is available on the long-term risk of cardiovascular disease (CVD) associated with hypertriglyceridaemia (HTG) in the Chinese population. We estimated this risk over a 23-year period in participants recruited from among those included in the Da Qing Diabetes Study.

Methods: A total of 833 Chinese adults including 379 with normal glucose levels and 454 with hyperglycaemia were identified by their oral glucose tolerance in 1986 in Da Qing, China. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3163
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http://dx.doi.org/10.1002/dmrr.3163DOI Listing
April 2019
6 Reads

Hypertriglyceridemia-induced acute pancreatitis: progress on disease mechanisms and treatment modalities.

Discov Med 2019 02;27(147):101-109

Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, China.

Acute pancreatitis (AP) is a common and destructive inflammatory condition of the pancreas. Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) has become the second major cause of AP. Although the association between HTG and AP is well established, HTG as a risk factor of AP in the general population is not well identified. Read More

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February 2019
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Influence of hypertriglyceridemia, hyperbilirubinemia and hemolysis on thrombin generation in human plasma.

Clin Chem Lab Med 2019 Apr 2. Epub 2019 Apr 2.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Background Although accumulating evidence suggests that the hemostatic balance is impaired in patients with hypertriglyceridemia, hyperbilirubinemia or hemolytic anemias, little is known on the underlying biological mechanisms. This experimental study was aimed at exploring whether increasing values of triglycerides, bilirubin or cell-free hemoglobin promote thrombin generation in plasma. Methods Three different pools were prepared from three different sets of 20 normal routine plasma citrate samples. Read More

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http://dx.doi.org/10.1515/cclm-2019-0135DOI Listing
April 2019
4 Reads

Nutritional Support of Very Low Birth Weight Infants in a Tertiary Center in a Developing Country.

J Clin Med Res 2019 Apr 18;11(4):283-288. Epub 2019 Mar 18.

School of Pharmacy, University of Jordan, Amman, Jordan.

Background: Very low birth weight infants (VLBWIs) are at high risk for nutritional deficiency. Enteral feeding is usually challenged by increased risk of necrotizing enterocolitis (NEC). The nutritional needs of VLBWIs are usually dependent on parenteral nutrition during early postnatal life. Read More

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http://dx.doi.org/10.14740/jocmr3797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436563PMC
April 2019
2 Reads

Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.

Lipids Health Dis 2019 Apr 1;18(1):81. Epub 2019 Apr 1.

Laboratory Medicine Center, Lanzhou University Second Hospital, No. 82 Cuiyingmen Lanzhou, Lanzhou, 730030, Gansu, China.

Background: The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).

Methods: The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. Read More

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http://dx.doi.org/10.1186/s12944-019-1031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444567PMC
April 2019
2 Reads

Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride.

Oxid Med Cell Longev 2019 25;2019:9148920. Epub 2019 Feb 25.

Interdisciplinary Program in Bioinformatics and Department of Statistics, Seoul National University, 1 Kwanak-Ro, Kwanak-gu, Seoul 151-747, Republic of Korea.

Early menarche has been associated with increased risk of metabolic syndrome. Therefore, investigating the association of each component of metabolic syndrome with age at menarche, and interactions between them, might lead to a better understanding of metabolic syndrome pathogenesis. In this study, we evaluated age at menarche for risk of metabolic syndrome and associations with its components. Read More

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http://dx.doi.org/10.1155/2019/9148920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410422PMC
April 2019
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Clinical Applications of a Novel Selective PPARα Modulator, Pemafibrate, in Dyslipidemia and Metabolic Diseases.

J Atheroscler Thromb 2019 Mar 30. Epub 2019 Mar 30.

Sumitomo Hospital.

Fasting and postprandial hypertriglyceridemia is a risk factor for atherosclerotic cardiovascular diseases (ASCVD). Fibrates have been used to treat dyslipidemia, particularly hypertriglyceridemia, and low HDL-cholesterol (HDL-C). However, conventional fibrates have low selectivity for peroxisome proliferator-activated receptor (PPAR)α. Read More

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http://dx.doi.org/10.5551/jat.48918DOI Listing

Oral administration of a new HRI activator as a new strategy to improve High-Fat-Diet-induced glucose intolerance, hepatic steatosis and hypertriglyceridemia through FGF21.

Br J Pharmacol 2019 Mar 30. Epub 2019 Mar 30.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain.

Background And Purpose: Fibroblast growth factor 21 (FGF21) has emerged as a therapeutic strategy for treating type 2 diabetes mellitus due to its antidiabetic effects, and this has led to the development of FGF21 long-acting analogs. These compounds have some limitations, including requiring subcutaneous injection and their prolonged pharmacodynamic effect compared with native FGF21, which might be responsible for their reported side effects.

Experimental Approach: We have previously demonstrated that intraperitoneal administration of heme-regulated eukaryotic translation initiation factor 2α (eIF2α) kinase (HRI) activators increases hepatic and circulating levels of FGF21. Read More

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http://dx.doi.org/10.1111/bph.14678DOI Listing
March 2019
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HIV and cART-Associated Dyslipidemia Among HIV-Infected Children.

J Clin Med 2019 Mar 28;8(4). Epub 2019 Mar 28.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children.

Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Read More

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http://dx.doi.org/10.3390/jcm8040430DOI Listing

The effect of chronic oral vitamin D supplementation on adiposity and insulin secretion in hypothalamic obese rats.

Br J Nutr 2019 Mar 29:1-27. Epub 2019 Mar 29.

Biologics Science and Health Center, Laboratory of Endocrine and Metabolic Physiology,University of West Parana (UNIOESTE),Cascavel, PR,Brazil.

Reduced plasma vitamin D levels may contribute to excessive white adipose tissue, insulin resistance and dyslipidemia. We evaluated the effect of chronic oral vitamin D supplementation on adiposity and insulin secretion in monosodium glutamate (MSG)-treated rats. During their first five days of life, male neonate rats received subcutaneous injections of MSG (4g/Kg), while the control (CON) group received saline solution. Read More

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http://dx.doi.org/10.1017/S0007114519000667DOI Listing
March 2019
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Prevalence and Risk Factors for Metabolic Syndrome among Hypertensive Patients Attending the General Outpatient Clinic of a Tertiary Hospital in North Central Nigeria.

West Afr J Med 2019 Jan-Apr;36(1):5-10

Department of Family Medicine, Bingham University Teaching Hospital, Jos. Nigeria.

Background: Metabolic syndrome is an important cause of morbidity and mortality. It is important to identify those at risk and initiate early interventions to prevent or delay its onset and complications.

Methods: It was a hospital-based descriptive cross-sectional study conducted from 1 September to 31 October, 2014. Read More

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March 2019
2 Reads

Pitfalls in hypertriglyceridemia induced acute pancreatitis.

Turk J Gastroenterol 2019 Mar;30(3):217-219

Department of Gastroenterology, Acibadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey.

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http://dx.doi.org/10.5152/tjg.2019.110319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428508PMC

Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B.

FASEB J 2019 Mar 28:fj201802704R. Epub 2019 Mar 28.

Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Hypersecretion of hepatic very LDL (VLDL)-associated triglyceride (TG) is the hallmark of hypertriglyceridemia. The estrogen-related receptor γ (ERRγ), an orphan nuclear receptor, plays crucial roles in the regulation of metabolic homeostasis, including TG formation in the liver. It remains unclear whether ERRγ regulates hepatic VLDL-TG secretion. Read More

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http://dx.doi.org/10.1096/fj.201802704RDOI Listing
March 2019
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Prevalence of Metabolic Syndrome and Associated Risk Factors among Men in a Rural Health Centre Area in Tamil Nadu.

J Lifestyle Med 2019 Jan 31;9(1):44-51. Epub 2019 Jan 31.

Department of Community Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Kanchipuram District, Tamil Nadu, India.

Background: MetS is one of the emerging health problems of the world with prevalence higher among Asians, including Indians, and is rising especially in the rural area. Hence, the objectives were to estimate the prevalence of MetS and its association with life style risk factors among adult men.

Methods: Cross-Sectional based study conducted in the rural area of Kancheepuram District recruiting 360 participants at the age group of 20-40 years by PPS from 9 villages and from each village participants were selected by simple random sampling. Read More

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http://dx.doi.org/10.15280/jlm.2019.9.1.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425909PMC
January 2019
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The association of intraocular pressure with metabolic syndrome and its components: a Meta-analysis and systematic review.

Int J Ophthalmol 2019 18;12(3):510-516. Epub 2019 Mar 18.

Department of Ophthalmology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China.

Aim: To perform a Meta-analysis to explore the correlation between metabolic syndrome and intraocular pressure (IOP).

Methods: We searched PubMed and Embase in November 2017 for studies discussing the relationship between metabolic syndrome components and IOP in patients. Pearson correlation coefficients, odds ratios and standardized betas were extracted from inclusive studies. Read More

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http://dx.doi.org/10.18240/ijo.2019.03.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423386PMC

Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A.

Circ J 2019 Mar 26. Epub 2019 Mar 26.

Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital.

Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1082DOI Listing
March 2019
4 Reads

Treatment of hypertriglyceridemia-induced acute pancreatitis with therapeutic plasma exchange in 2 pregnant patients.

J Obstet Gynaecol 2019 Mar 28:1-3. Epub 2019 Mar 28.

a Department of Gastroenterology, School of Medicine , Adnan Menderes University , Aydin , Turkey.

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http://dx.doi.org/10.1080/01443615.2018.1553939DOI Listing

Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats.

Chronobiol Int 2019 Mar 28:1-12. Epub 2019 Mar 28.

a Laboratory of Nutritional Biochemistry , Nagoya University , Nagoya , Japan.

Excessive sucrose intake, known as fructose toxicity, leads to fatty liver, hyperlipidemia, and metabolic syndrome. Circadian disorders also contribute to metabolic syndrome. Here, we investigated the effect of excessive sucrose intake on circadian rhythms of the small intestine, the main location of sucrose absorption, to elucidate a mechanism of sucrose-induced abnormal lipid metabolism. Read More

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https://www.tandfonline.com/doi/full/10.1080/07420528.2019.1
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http://dx.doi.org/10.1080/07420528.2019.1592185DOI Listing
March 2019
3 Reads

High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal.

An Acad Bras Cienc 2019 Mar 21;91(1):e20180314. Epub 2019 Mar 21.

Universidade Federal de Mato Grosso, Instituto de Ciências Exatas e da Terra, Departamento de Química, Laboratório de Bioquímica Pesquisa, Av. Fernando Correa da Costa, 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil.

Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control group (commercial feed), and HF-STZ group, (66.5%-commercial feed, 13. Read More

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http://dx.doi.org/10.1590/0001-3765201920180314DOI Listing
March 2019
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The association of metabolic syndrome and its components with serum prostate-specific antigen levels.

Eur J Cancer Prev 2019 Mar 25. Epub 2019 Mar 25.

Departments of Health Management Center.

Metabolic syndrome (MetS) can increase the risk of prostate cancer. Prostate-specific antigen (PSA) is the marker for prostate cancer puncture screening. The aim of our study was to investigate the association between MetS and its components with PSA levels. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000508DOI Listing
March 2019
1 Read