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    14074 results match your criteria Hypertriglyceridemia

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    The effects of diets enriched in omega-3 polyunsaturated fatty acids on systemic vaccinia virus infection.
    Sci Rep 2017 Nov 22;7(1):15999. Epub 2017 Nov 22.
    Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
    Omega-3 polyunsaturated fatty acids (PUFA, n-3 fatty acids), the key components of fish and flaxseed oils, are increasingly consumed by the public because of their potential health benefits and are available by prescription for hypertriglyceridemia. However, numerous studies have shown that these compounds are immunoregulatory and immunosuppressive and thus may increase susceptibility to infection. In this study, we tested the effects of the amount of fat and the types of fatty acid in the diet on infection by vaccinia virus, an acute infection that begins in the respiratory tract and spreads by viremia to internal organs. Read More

    Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases.
    Arch Gynecol Obstet 2017 Nov 21. Epub 2017 Nov 21.
    Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, No.17 Yongwai Zheng Street, Nanchang, 330006, China.
    Purpose: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP).

    Methods: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. Read More

    Chewing the Fat: A Case Report of Therapeutic Plasma Exchange in Hypertriglyceridemia-Induced Pancreatitis.
    Hawaii J Med Public Health 2017 Nov;76(11 Suppl 2):13-15
    Tripler Army Medical Center, Honolulu, HI 96859.
    Hypertriglyceridemia is the third most common etiology of acute pancreatitis, but lacks a clear, evidence-based treatment approach. We present the case of a 25-year-old man who was admitted eleven times over seven years for hypertriglyceridemia-induced pancreatitis. In his first ten admissions, he received conservative therapy. Read More

    Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1.
    Arterioscler Thromb Vasc Biol 2017 Nov 21. Epub 2017 Nov 21.
    From the School of Public Health (K.C., Q.W., C.Y.) and Department of Surgery, The First Affiliated Hospital (K.H.), Anhui Medical University, Hefei, China; Section of Endocrinology, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (K.C., X.W., P.C., K.J.W.); and Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, Sweden (K.J.W.).
    Objective: Type 2 diabetes mellitus (T2DM) and the atherometabolic syndrome exhibit a deadly dyslipoproteinemia that arises in part from impaired hepatic disposal of C-TRLs (cholesterol- and triglyceride-rich remnant apoB [apolipoprotein B] lipoproteins). We previously identified syndecan-1 as a receptor for C-TRLs that directly mediates endocytosis via rafts, independent from coated pits. Caveolins and flotillins form rafts but facilitate distinct endocytotic pathways. Read More

    Sugar industry sponsorship of germ-free rodent studies linking sucrose to hyperlipidemia and cancer: An historical analysis of internal documents.
    PLoS Biol 2017 Nov 21;15(11):e2003460. Epub 2017 Nov 21.
    Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California, United States of America.
    In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr. Read More

    Emergence of Mixed-Oil Fat Emulsions for Use in Parenteral Nutrition.
    JPEN J Parenter Enteral Nutr 2017 Nov 1:148607117742595. Epub 2017 Nov 1.
    1 Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.
    Since early work by Wretlind and Schuberth led to the development of a stable and safe intravenous fat emulsion (IFE) using soybean oil (SO) and egg phospholipid emulsifier, IFEs have become a crucial source of essential fatty acids and nonprotein energy in parenteral nutrition. However, largely due to their high ω-6 polyunsaturated fatty acid (PUFA) and phytosterol content, SO IFEs have been associated with complications, including a proinflammatory profile and hypertriglyceridemia, as well as intestinal failure-associated liver disease. Subsequent generations of IFEs have used other sources of triglycerides, including medium-chain triglycerides (MCTs), olive oil (OO), and fish oil (FO), to reduce the SO component. Read More

    Metabolic disorders and cardiovascular risk in people living with HIV/AIDS without the use of antiretroviral therapy.
    Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):598-606
    Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
    Introduction: Metabolic disorders in people living with HIV/AIDS (PLH) have been described even before the introduction of antiretroviral (ARV) drugs in the treatment of HIV infection and are risk factors for cardiovascular diseases. Based on this, the purpose of this study was to assess metabolic disorders and cardiovascular risk in PLH before the initiation of antiretroviral treatment (ART).

    Methods: This was a cross-sectional descriptive study of 87 PLH without the use of ART, which was carried out between January and September 2012 at a specialized infectious diseases center in Minas Gerais, Brazil. Read More

    Body fat redistribution and changes in lipid and glucose metabolism in people living with HIV/AIDS.
    Rev Bras Epidemiol 2017 Jul-Sep;20(3):526-536
    Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - Ribeirão Preto (SP), Brasil.
    Introduction: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART).

    Objective: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART.

    Methods: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC). Read More

    Evaluation of lipid profiles in patients treated with capecitabine
    Turk J Med Sci 2017 08 23;47(4):1206-1209. Epub 2017 Aug 23.
    Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor activity. The main adverse effects are hand-foot syndrome, diarrhea, and dermatitis. In recent years, hypertriglyceridemia has been reported in patients treated with capecitabine. Read More

    Metabolic syndrome and low high-density lipoprotein cholesterol are associated with adverse pathological features in patients with prostate cancer treated by radical prostatectomy.
    Urol Oncol 2017 Nov 16. Epub 2017 Nov 16.
    Pathology Department, University Hospital of Tours, Tours, France; ReSCaP prostate cancer network, Canceropôle Grand Ouest, France.
    Background: Previous studies have suggested a link between metabolic syndrome (MetS) and prostate cancer (PCa). In the present study, we aimed to assess the association between MetS and markers of PCa aggressiveness on radical prostatectomy (RP).

    Methods: All patients consecutively treated for PCa by RP in 6 academic institutions between August 2013 and July 2016 were included. Read More

    Serum concentrations of fetuin B in lipodystrophic patients.
    Cytokine 2017 Nov 16. Epub 2017 Nov 16.
    Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany.
    Objective: Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. Regulation of fetuin B in patients with lipodystrophy (LD) - a disease group which is characterized by subcutaneous adipose tissue loss, hypertriglyceridemia, hepatic steatosis, insulin resistance, and dysregulation of several adipokines - has not been elucidated so far.

    Material And Methods: Serum fetuin B levels were determined in 37 patients with LD, as well as in a control cohort consisting of 37 non-LD participants matched for age, gender, and body mass index. Read More

    Molecular and functional characterization of familial chylomicronemia syndrome.
    Atherosclerosis 2017 Nov 14. Epub 2017 Nov 14.
    Department of Cardiovascular and Internal Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa, Japan.
    Background And Aims: Familial chylomicronemia syndrome is a rare autosomal recessive disorder leading to severe hypertriglyceridemia (HTG) due to mutations in lipoprotein lipase (LPL)-associated genes. Few data exist on the clinical features of the disorder or on comprehensive genetic approaches to uncover the causative genes and mutations.

    Methods: Eight patients diagnosed with familial hyperchylomicronemia with recessive inheritance were included in this study (two males and six females; median age of onset 23. Read More

    Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis.
    Clin Case Rep 2017 Nov 12;5(11):1756-1764. Epub 2017 Sep 12.
    Obstetrics and Gynecology ServiceBrest Medical University HospitalBrestFrance.
    Diagnosis of hemophagocytic syndrome remains a challenge in particular during pregnancy. Concomitant presence of clinical and biological signs, for example, fever, pancytopenia, hyperferritinemia, and hypertriglyceridemia, should alert clinicians to suspect HPS and proceed to prompt treatments. Read More

    Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease risk.
    Int J Obes (Lond) 2017 Nov 20. Epub 2017 Nov 20.
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, UK.
    Background/objective: Fat distribution is a strong and independent predictor of type 2 diabetes (T2D) and cardiovascular disease (CVD) and is usually determined using conventional anthropometry in epidemiological studies. Dual-energy X-ray absorptiometry (DXA) can measure total and regional adiposity more accurately. Nonetheless, whether DXA provides more precise estimates of cardiovascular risk in relation to total and regional adiposity is not known. Read More

    Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding.
    J Nutr Biochem 2017 Oct 12;52:45-53. Epub 2017 Oct 12.
    Maruha Nichiro Corporation, Tsukuba, Ibaraki, Japan.
    Chrononutrition is the science of nutrition based on chronobiology. Numerous epidemiological studies have shown that fish oil (FO) reduces the risk of cardiovascular events through various actions such as lowering triglycerides. The present study aimed to determine the time of day when the hypertriglyceridemia-decreasing ability of FO is optimal in mice. Read More

    Lipid profiles and determinants of total cholesterol and hypercholesterolaemia among 25-74 year-old urban and rural citizens of the Yangon Region, Myanmar: a cross-sectional study.
    BMJ Open 2017 Nov 15;7(11):e017465. Epub 2017 Nov 15.
    Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
    Objective: The first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar. The second is to investigate the association between urban-rural location and total cholesterol.

    Design: Two cross-sectional studies using the WHO STEPS methodology. Read More

    Clinical and biochemical correlates of male hypogonadism in type 2 diabetes.
    Andrology 2017 Nov 16. Epub 2017 Nov 16.
    Department of Medicine and Service of Endocrinology and Nutrition, University of Salamanca, University Clinical Hospital of Salamanca, Salamanca, Spain.
    The origin of hypogonadism, a condition including both symptoms and biochemical criteria of androgen deficiency, in type 2 diabetes is poorly known. In a cross-sectional study of 267 unselected patients, we analyzed the potential correlation of several clinical and biochemical variables as well as chronic micro- and macrovascular diabetic complications with hypogonadism. Hypogonadism was present in 46 patients (17. Read More

    Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.
    Rev Diabet Stud 2017 Summer-Fall;14(2-3):311-328. Epub 2017 Oct 10.
    Doctorate in Tropical Medicine, Faculty of Medicine, Universidad de Cartagena. Cartagena de Indias, Colombia.
    Background: Adiponectin is a hormone secreted by adipose tissue. It regulates glycolysis and lipolysis and is involved in the pathophysiology of diabetes and related disorders. Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32. Read More

    Reversible severe fatty liver induced by capecitabine: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8547
    Department of Tumor Rehabilitation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Rationale: Capecitabine (CAP) is a chemotherapeutic agent used to treat breast and gastrointestinal cancers. The most common adverse reactions of CAP primarily included gastrointestinal and dermatological effects. Whereas, the CAP-induced fatty liver had never been reported. Read More

    Case of familial hyperlipoproteinemia type III hypertriglyceridemia induced acute pancreatitis: Role for outpatient apheresis maintenance therapy.
    World J Gastroenterol 2017 Oct;23(40):7332-7336
    Division of Gastroenterology and Liver Disease, Department of Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, United States.
    Hypertriglyceridemic pancreatitis (HTGP) accounts for up to 10% of acute pancreatitis presentations in non-pregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type III who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP. Read More

    Are Polyunsaturated Fatty Acid Metabolites, the Protective Effect of 4-hydroxytyrosol on Human Red Blood Cell Membranes and Oxidative Damage (4-hydroxyalkenals) Compatible in Hypertriglyceridemic Patients?
    Pharmacogn Mag 2017 Oct 11;13(Suppl 3):S561-S566. Epub 2017 Oct 11.
    Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende (CS), Italy.
    Background: Increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are demonstrated in plasma of uremic patients. A study showed that the comparison of erythrocytes of healthy and diseased patients (obese, hypertensive, and Type 2 diabetics) with age is associated to a disturbed oxidant/antioxidant balance when obesity is associated with hypertension. 4-hydroxytyrosol is shown to significantly protect red blood cells (RBCs) from oxidative damage (4-HNE). Read More

    Association between metabolic syndrome and sensorineural hearing loss: a cross-sectional study of 11,114 participants.
    Diabetes Metab Syndr Obes 2017 6;10:459-465. Epub 2017 Nov 6.
    Social Determinants of Health Research Center, Occupational Medicine Center, Urmia University of Medical Sciences, Urmia.
    Background/objectives: Hearing loss (HL) is associated with certain diseases and affects health, resulting in a low quality of life. Some components of the metabolic syndrome (MetS) coincide with the risk factors for sensorineural hearing loss (SNHL). To date, very few studies have examined the link between MetS and HL. Read More

    Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia.
    Physiol Res 2017 Nov 10. Epub 2017 Nov 10.
    Department of Cardio-Metabolic Research, Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
    Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b. Read More

    Impaired Secretion of Active GLP-1 in Patients with Hypertriglyceridaemia: A Novel Lipotoxicity Paradigm?
    Diabetes Metab Res Rev 2017 Nov 14. Epub 2017 Nov 14.
    Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
    Aim: Lipotoxicity plays an important role in the pathogenesis of β-cell dysfunction. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that exerts beneficial effects on the number and function of islet β cells. However, the effect of lipotoxicity on GLP-1 secretion is still unknown. Read More

    Chylomicronemia risk factors ranked by importance for the individual and community in 108,711 women and men.
    J Intern Med 2017 Nov 11. Epub 2017 Nov 11.
    Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    Background: Hypertriglyceridemia prevalence is increasing as more individuals become obese, and chylomicronemia risk factors for the individual and community have not been described previously.

    Objective: To describe chylomicronemia risk factors in the general population for individuals and community.

    Methods: 108,711 individuals from the Copenhagen General Population Study were grouped as unlikely chylomicronemia (nonfasting triglycerides <2mmol/L(177 mg/dL)), possible chylomicronemia (2-4. Read More

    Microduplication of 10q26.3 in a Chinese hypertriglyceridemia patient.
    Mol Cell Probes 2017 Nov 9. Epub 2017 Nov 9.
    The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410013, China; The Second Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address:
    Hypertriglyceridemia (HTG) plays an important role in the development and progression of atherosclerosis. It is inherited in an autosomal dominant pattern with a frequency of approximately 1:1,000,000 worldwide. Previous study has demonstrated that more than six genes underlie this disorder. Read More

    Early changes of blood lipid levels during psychotropic drug treatment as predictors of long-term lipid changes and of new onset dyslipidemia.
    J Clin Lipidol 2017 Oct 16. Epub 2017 Oct 16.
    Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:
    Background: Cardiovascular diseases and dyslipidemia represent a major health issue in psychiatry. Many psychotropic drugs can induce a rapid and substantial increase of blood lipid levels.

    Objective: This study aimed to determine the potential predictive power of an early change of blood lipid levels during psychotropic treatment on long-term change and on dyslipidemia development. Read More

    ApoCIII as a Cardiovascular Risk Factor and Modulation by the Novel Lipid-Lowering Agent Volanesorsen.
    Curr Atheroscler Rep 2017 Nov 9;19(12):62. Epub 2017 Nov 9.
    Baylor University Medical Center, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Baylor Heart and Vascular Institute, Dallas, TX, USA.
    Purpose Of Review: Apolipoprotein CIII (ApoCIII) is now recognized as a key regulator in severe hypertriglyceridemia, chylomicronemia, and conditions of triglyceride-rich lipoprotein (TRL) remnant excess due to its inhibition of lipoprotein lipase (LPL) and hepatic lipase, leading to decreased hepatic reuptake of TRLs, as well as enhanced synthesis and secretion of VLDL from the liver. ApoCIII gain-of-function mutations are associated with atherosclerosis and coronary heart disease (CHD), and contribute to the development of cardiometabolic syndrome, hypertriglyceridemia, and type 2 diabetes mellitus. Conversely, loss-of-function mutations in ApoCIII are associated with lower levels of plasma triglycerides (TG), attenuation of vascular inflammatory processes such as monocyte adhesion and endothelial dysfunction, and potentially, a reduction in the incidence and progression of atherosclerosis and cardioprotection. Read More

    Novel associations of bile acid diarrhoea with fatty liver disease and gallstones: a cohort retrospective analysis.
    BMJ Open Gastroenterol 2017 26;4(1):e000178. Epub 2017 Oct 26.
    Division of Digestive Diseases, Imperial College London, London, UK.
    Background: Bile acid diarrhoea (BAD) is a common cause of chronic diarrhoea with a population prevalence of primary BAD around 1%. Previous studies have identified associations with low levels of the ileal hormone fibroblast growth factor 19 (FGF19), obesity and hypertriglyceridaemia. The aim of this study was to identify further associations of BAD. Read More

    The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto's Thyroiditis Treated with Levothyroxine and Selenomethionine.
    Exp Clin Endocrinol Diabetes 2017 Nov 8. Epub 2017 Nov 8.
    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
    Background Levothyroxine and selenomethionine were found to reduce thyroid antibody titers in patients with Hashimoto's thyroiditis. The same effect was produced by intensive statin therapy. The aim of the present study was to assess whether hypolipidemic agents modulate the impact of thyroid hormone supplementation and selenomethionine on thyroid autoimmunity. Read More

    Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist.
    J Endocrinol Invest 2017 Nov 7. Epub 2017 Nov 7.
    Chair of Pharmaceutical Chemistry, Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688, Kraków, Poland.
    Purpose: Previous studies have shown that several components of the metabolic syndrome, such as hypertension, obesity or imbalanced lipid and carbohydrate homeostasis, are associated with the sympathetic nervous system overactivity. Therefore, the inhibition of the adrenergic nervous system seems to be a reasonable and appropriate therapeutic approach for the treatment of metabolic disturbances. It has been suggested that non-selective adrenoceptor antagonists could be particularly beneficial, since α1-adrenoceptor antagonists can improve disrupted lipid and carbohydrate profiles, while the inhibition of the α2-adrenoceptor may contribute to body weight reduction. Read More

    Association of smoking with prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals.
    Biomed Rep 2017 Nov 27;7(5):429-438. Epub 2017 Sep 27.
    Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514-8507, Japan.
    Smoking is a significant risk factor for cardiovascular diseases (CVDs). Given that certain common pathologies, including hypertension, dyslipidemia and type 2 diabetes mellitus, are major risk factors for CVDs, the association of smoking with CVDs may be attributable, at least in part, to its effects on common diseases. The aim of the present study was to determine the association of smoking with the prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals. Read More

    Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins.
    J Biomed Res 2017 Nov 4. Epub 2017 Nov 4.
    Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA; Department University of Crete, School of Medicine, Heraklion, Crete, Greece.
    In this review, we focus on the pathway of biogenesis of HDL, the essential role of apoA-I, ATP binding cassette transporter A1 (ABCA1), and lecithin: cholesterol acyltransferase (LCAT) in the formation of plasma HDL; the generation of aberrant forms of HDL containing mutant apoA-I forms and the role of apoA-IV and apoE in the formation of distinct HDL subpopulations. The biogenesis of HDL requires functional interactions of the ABCA1 with apoA-I (and to a lesser extent with apoE and apoA-IV) and subsequent interactions of the nascent HDL species thus formed with LCAT. Mutations in apoA-I, ABCA1 and LCAT either prevent or impair the formation of HDL and may also affect the functionality of the HDL species formed. Read More

    FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism.
    Biochem Biophys Res Commun 2017 Nov 3. Epub 2017 Nov 3.
    Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:
    Lipodystrophies are disorders that directly affect lipid metabolism and storage. Familial partial lipodystrophy type 2 (FPLD2) is caused by an autosomal dominant mutation in the LMNA gene. FPLD2 is characterized by abnormal adipose tissue distribution. Read More

    Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort.
    J Diabetes Complications 2017 Sep 19. Epub 2017 Sep 19.
    Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
    Aims: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.

    Methods: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression. Read More

    Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis.
    Clin Rheumatol 2017 Nov 3. Epub 2017 Nov 3.
    Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico.
    Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. Read More

    Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit.
    Gut 2017 Nov 3. Epub 2017 Nov 3.
    Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
    Objective: Butyrate exerts metabolic benefits in mice and humans, the underlying mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite and energy expenditure, and to what extent these two components contribute to the beneficial metabolic effects of butyrate.

    Design: Acute effects of butyrate on appetite and its method of action were investigated in mice following an intragastric gavage or intravenous injection of butyrate. Read More

    Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism.
    Atherosclerosis 2017 Oct 20;267:49-60. Epub 2017 Oct 20.
    Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
    Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting as a cofactor of lipoprotein lipase (LPL), the main enzyme that hydrolyses plasma triglycerides (TG) on TRL. Here, we present an overview of the role of apoC-II in TG metabolism, emphasizing recent novel findings regarding its transcriptional regulation and biochemistry. Read More

    Subtle metabolic alterations in adolescents with obesity and polycystic ovarian syndrome.
    Gac Med Mex 2017 ;153(Supl. 2):S34-S41
    Escuela de Nutrición, Universidad Anáhuac Campus Norte, Ciudad de México.
    Objective: To evaluate the frequency of some subtle metabolic alterations in a group of adolescents with obesity and polycystic ovary syndrome (PCOS).

    Materials And Methods: A cross-sectional, comparative study was conducted in a group of adolescents with obesity, and characterized as with or without PCOS according with the Rotterdam Consensus. Medical history, anthropometry, gynecologic pelvic ultrasound (to evaluate ovarian volumes, number of antral follicles and endometrial width), as well as serum glucose, insulin, lipoproteins, interleukin-6, tumor necrosis factor alpha, total testosterone, dehydroepiandrosterone, sexual hormones binding globulin, leptin, adiponectin and insulin-like growth factor 1, the free-androgen index, free and available testosterone, and homeostatic model assessment index were calculated. Read More

    Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background.
    Atheroscler Suppl 2017 Nov;30:294-302
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital and Medical Faculty Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. Electronic address:
    Objective: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for oxidized LDL in endothelial cells. LOX-1 is highly expressed in atherosclerotic plaques. The impact of LOX-1 on development of endothelial dysfunction in large vessels in absence or presence of atherosclerosis-prone conditions has not been studied to date. Read More

    The role of antisense oligonucleotide therapy against apolipoprotein-CIII in hypertriglyceridemia.
    Atheroscler Suppl 2017 Nov 31;30:19-27. Epub 2017 May 31.
    Center for Endocrinology, Diabetes and Preventive Medicine (ZEDP), University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. Electronic address:
    Increased triglyceride levels (higher than ∼1000 mg/dL) are associated with an increased risk for pancreatitis. Apolipoprotein-CIII (apo-CIII) plays a key role in the metabolism of triglycerides and triglyceride-rich lipoproteins. While loss of function mutations in the gene encoding apo-CIII (APOC3) are associated with low triglyceride levels and a decreased risk for cardiovascular disease (CVD), overexpression of APOC3 is associated with hypertriglyceridemia. Read More

    Everolimus for pediatric patients with acute graft-versus-host disease after hematopoietic stem cell transplantation: A pilot study.
    Medicine (Baltimore) 2017 Nov;96(44):e8464
    aDepartment of Pediatrics, Chung Shan Medical University Hospital bSchool of Medicine, Chung Shan Medical University cDepartment of Nursing, College of Medicine and Nursing, Hungkuang University dDivision of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital eCollege of Medicine, Chang Gung University, Taoyuan fDivision of Pediatric Hematology-Oncology, Children's Hospital, China Medical University gDepartment of Biotechnology and Bioinformatics, Asia University hSchool of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
    Acute graft-versus-host disease (aGVHD) is a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Due to the poor prognosis for patients not responding to first-line steroids treatment, improvements in aGVHD therapy are needed. Everolimus is a promising candidate that combines immunosuppressive properties with anti-neoplastic effects. Read More

    Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes.
    J Biomed Res 2017 Nov 1. Epub 2017 Nov 1.
    Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.
    Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Read More

    The Associations of Endotoxemia With Systemic Inflammation, Endothelial Activation, and Cardiovascular Outcome in Kidney Transplantation.
    J Ren Nutr 2017 Oct 28. Epub 2017 Oct 28.
    Department of Nephrology & Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK; Centre for Translational Inflammation Research, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address:
    Objective: Cardiovascular disease is the leading cause of death in kidney transplant recipients (KTRs), yet incompletely accountable by traditional risk factors. Inflammation is an unconventional cardiovascular risk factor, with gut-derived endotoxemia potentially driving inflammation and endothelial disease. Comparable data are lacking in kidney transplantation. Read More

    Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance.
    Redox Rep 2017 Oct 31:1-6. Epub 2017 Oct 31.
    a Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos , Universidade Federal de Pelotas , Pelotas , Brazil.
    Objective: Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX).

    Methods: Wistar rats received water or extracts of Eugenia uniflora or Psidium cattleianum, once a day for 21 days. Read More

    Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs.
    PLoS One 2017 31;12(10):e0187315. Epub 2017 Oct 31.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
    Leptin and its receptor play several physiological roles in the canine gallbladder, and the dysregulation of leptin might play a role in the pathogenesis of gallbladder diseases such as gallbladder mucocele. Previous studies revealed a positive association between hyperlipidemia and gallstones in humans. However, the latter is still unclear in dogs with cholelithiasis. Read More

    Prenatal and/or postnatal high-fat diet alters testicular parameters in adult Wistar Albino rats.
    Histol Histopathol 2017 Oct 30:11941. Epub 2017 Oct 30.
    Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Here, we evaluated the effects of a high-fat diet during the prenatal and/or postnatal period on the metabolic parameters and testes of 4-month-old Wistar rats. The experimental groups, composed of male Wistar rats, were: C/C (n=8), HF/HF (n=8) (pups with the same diet as their dams, after weaning), C/HF (n=8), and HF/C (n=9) (pups with a different diet after weaning, from that of their dams). The biometric parameters, blood glucose levels, serum levels, the gonadosomatic index, sperm parameters, testes, and genital fat deposits were evaluated. Read More

    Acute pancreatitis after coronary artery bypass surgery treated by plasmapheresis.
    Turk J Gastroenterol 2017 Oct 30. Epub 2017 Oct 30.
    Department of Cardiovascular Surgery, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.
    Acute pancreatitis (AP) is a common disorder and an important cause of morbidity and mortality. There are different causes of AP, including gallstones and excessive alcohol consumption. AP after coronary artery bypass grafting (CABG) surgery is seen less frequently but it is associated with a high mortality rate due to its atypical and misleading symptoms. Read More

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