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    In vitro fertilization-induced hypertriglyceridemia with secondary acute pancreatitis and diabetic ketoacidosis.
    SAGE Open Med Case Rep 2017 18;5:2050313X16689209. Epub 2017 Jan 18.
    Department of Internal Medicine, Ain Wazein Hospital, El Chouf, Lebanon.
    Introduction: In vitro fertilization is becoming more and more popular lately, as such light is to be shed on any possible related complication. One of these complications is the possible hormonal effect on the lipid profile of the patients.

    Case Presentation: We present a case of a 39-year-old woman with no prior or family history of dyslipidemia, who presented with post in vitro fertilization severe hypertriglyceridemia and secondary acute pancreatitis and diabetic ketoacidosis. Read More

    Altered lipid metabolism in rat offspring of dams fed a low-protein diet containing soy protein isolate.
    Life Sci 2017 Feb 20. Epub 2017 Feb 20.
    Department of Food and Nutrition, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
    Aims: Substantial studies have reported that maternal protein restriction may induce later development of cardiovascular disease in offspring by impairing antioxidant system and lipid metabolism. Because a unique amino acid composition of soy protein isolate has shown to provide health benefits, including hypolipidemic effects, we investigated effects of maternal low-protein diet composed of low-isoflavone soy protein isolate (SPI) on oxidative stress and lipid metabolism in offspring.

    Main Methods: Sprague-Dawley dams were fed 20% or 10% SPI diet throughout pregnancy and lactation. Read More

    Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review.
    Arch Endocrinol Metab 2017 Feb 13. Epub 2017 Feb 13.
    Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
    Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. Read More

    Cytomegalovirus infection in patients with lupus nephritis: clinical and laboratory features and therapeutic considerations.
    Clin Exp Med 2017 Feb 17. Epub 2017 Feb 17.
    Department of Nephrology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
    To better clarify the clinical features and therapeutic strategy of CMV infection in lupus nephritis patients, we retrospectively surveyed a total of 40 lupus nephritis patients, who had been hospitalized and underwent renal biopsy and diagnosed as having CMV infection during their hospitalization at our institution within the last 10 years. The percentage of CMV infections in the entire hospitalized lupus nephritis population was 5.3% (40/755). Read More

    Laparoscopic roux-en-y gastric bypass vs. laparoscopic sleeve gastrectomy for morbid obesity: a systematic review and meta-analysis of lipid effects at one year post-surgery.
    Minerva Endocrinol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Obstetrics and Gynaecology, Hospital del Mar, Barcelona, Spain.
    Introduction: Results of the effects of Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) on triglyceride and high-density lipoprotein (HDL) cholesterol levels are controversial. Moreover, previous meta-analyses focused on global dyslipidaemia remission, but did not include the separate remission rates of the different lipid fractions. Hence, the aim of the present meta-analysis was to compare the outcomes (concentration change and remission rates) of GB and SG on diverse lipid disorders one year post-bariatric surgery (BS). Read More

    Severe Hypertriglyceridemia Induced by Sirolimus Treated With Medical Management Without Plasmapheresis.
    J Pharm Pract 2017 Jan 1:897190017692920. Epub 2017 Jan 1.
    3 Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA.
    Hypertriglyceridemia and hyperlipidemia are the most remarkable metabolic complications seen with long-term sirolimus therapy. We report the case of a 36-year-old woman status post bilateral lung transplantation on a maintenance immunosuppression regimen of sirolimus, tacrolimus, and prednisone who presented with status migrainosus, chest pain, abdominal discomfort, and triglyceride levels greater than 4425 mg/dL. In previously reported cases of severe hypertriglyceridemia that developed on maintenance sirolimus therapy, plasmapheresis has been utilized as an early strategy to rapidly lower triglycerides in order to minimize the risk of acute complications such as pancreatitis, but our case was managed medically without plasmapheresis. Read More

    Spectrum of Disease Associated with Partial Lipodystrophy (PL): Lessons from a Trial Cohort.
    Clin Endocrinol (Oxf) 2017 Feb 15. Epub 2017 Feb 15.
    Brehm Center for Diabetes Research and Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, USA.
    Context: Partial lipodystrophy (PL) is associated with metabolic co-morbidities but may go undiagnosed as the disease spectrum is not fully described.

    Objective: Define disease spectrum in PL using genetic, clinical (historical, morphometric) and laboratory characteristics.

    Design: Cross-sectional evaluation. Read More

    Serum Triglyceride Lowering Effect of Cilnidipine in Patients With Essential Hypertension.
    Cardiol Res 2016 Oct 3;7(5):173-177. Epub 2016 Nov 3.
    Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
    Background: Many epidemiological studies have established the relationship between hypertension and dyslipidemia. Calcium channel blockers (CCBs) are one of the first-line drugs for newly diagnosed patients with essential hypertension. Cilnidipine as a newer CCB acting by blocking both L- and N-type calcium channels possesses additional beneficial effects apart from lowering blood pressure (BP). Read More

    Bioequivalence Demonstration for Ω-3 Acid Ethyl Ester Formulations: Rationale for Modification of Current Guidance.
    Clin Ther 2017 Feb 8. Epub 2017 Feb 8.
    Sancilio and Company, Inc, Riviera Beach, Florida.
    The US Food and Drug Administration (FDA) draft guidance for establishing bioequivalence (BE) of ω-3 acid ethyl esters (containing both eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA] as ethyl esters), used to treat severe hypertriglyceridemia, recommends the conduct of 2 studies: one with participants in the fasting state and one with participants in the fed state. For the fasting study, the primary measures of BE are baseline-adjusted EPA and DHA levels in total plasma lipids. For the fed study, the primary measures of BE are EPA and DHA ethyl esters in plasma. Read More

    A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid Technologies(TM) (ALT(®)) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza(®).
    Clin Ther 2017 Feb 9. Epub 2017 Feb 9.
    Department of Research and Development Sancilio and Company, Inc, Riviera Beach, Florida.
    Purpose: The US Food and Drug Administration has approved several highly purified ω-3 fatty acid prescription drugs for the treatment of severe hypertriglyceridemia. These differ in the amounts and forms of docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). This study compared the bioavailability of SC401 (1530 mg EPA-ethyl esters [EEs] and DHA-EEs plus Advanced Lipid Technologies(⁎) [ALT(†)], a proprietary lipid-delivery platform to improve absorption), with. Read More

    Excessive Consumption of Fructose Causes Cardiometabolic Dysfunctions Through Oxidative Stress and Inflammation.
    Can J Physiol Pharmacol 2017 Feb 10. Epub 2017 Feb 10.
    Institute of Cardiovascular Sciences , St. Boniface Research Center , 351 Tache Avenue, R3022 , Winnipeg, Manitoba, Canada , R2H 2A6 ;
    A rapid rise in obesity as well as physical inactivity in industrialized countries is associated with fructose consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress and elevated levels of uric acid are also part of this syndrome. Read More

    [Consensus document on the management of the atherogenic dyslipidaemia of the Spanish Society of Arteriosclerosis].
    Clin Investig Arterioscler 2017 Feb 6. Epub 2017 Feb 6.
    Servicio de Medicina Interna, Hospital de Bellvitge, CIBERobn, Fipec, Universidad de Barcelona, Idibell, Hospitalet de Llobregat, Barcelona, España.
    Positioning document and summary of recommendations recently published by the Working Group on Atherogenic Dyslipemia of the Spanish Society of Arteriosclerosis and by the European Society of Arteriosclerosis. Read More

    Integration of metabolomics, lipidomics and clinical data using a machine learning method.
    BMC Bioinformatics 2016 Nov 22;17(Suppl 15):440. Epub 2016 Nov 22.
    Medical Research Council, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.
    Background: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Certain nuclear hormone receptors (NRs) play a pivotal role in lipid and carbohydrate metabolism and have been highlighted as potential treatments for obesity. This realisation started a search for NR agonists in order to understand and successfully treat MetS and associated conditions such as insulin resistance, dyslipidaemia, hypertension, hypertriglyceridemia, obesity and cardiovascular disease. Read More

    "Hemophagocytic Lymphohistiocytosis after EBV reactivation and ibrutinib treatment in relapsed/refractory Chronic Lymphocytic Leukemia".
    Leuk Res Rep 2017 22;7:11-13. Epub 2017 Jan 22.
    Hematology Section, Azienda Ospedaliero-Universitaria Arcispedale S. Anna, Ferrara, Italy.
    Hemophagocytic Lymphohistiocytosis (HLH) is a rare syndrome characterized by ineffective T-cell and NK response. We report the clinical course of a patient with relapsed CLL who developed acute symptoms soon after starting ibrutinib. Hyperpyrexia, splenomegaly, hyperferritinemia, hypertriglyceridemia, cytopenias, and a typical cytokine pattern, i. Read More

    Dyslipidemia in Patients with a Cardiovascular Risk and Disease at the University Teaching Hospital of Yaoundé, Cameroon.
    Int J Vasc Med 2017 9;2017:6061306. Epub 2017 Jan 9.
    Department of Surgery, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
    Objective. To determine the frequency of lipid abnormalities in patients with a cardiovascular risk and disease at the University Teaching Hospital (UTH) of Yaoundé. Materials and Methods. Read More

    Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death.
    Oxid Med Cell Longev 2017 10;2017:1838679. Epub 2017 Jan 10.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of a high-fat diet (HFD), produces NAFLD-like features, including increased liver lipid content; decreased antioxidant power; increased expression of TNFα, TNFα receptor, cleaved caspase-1, and interleukin-1β; decreased expression of adiponectin receptor-2; and increased cell death. This phenotype is aggravated and additional NAFLD features are differentially induced in apoCIII mice fed a HFD. Read More

    [The 454th case: a 29-week pregnant woman with abdominal pain, hyperlipemia and multiorgan dysfunction].
    Zhonghua Nei Ke Za Zhi 2017 Feb;56(2):157-160
    Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    A 32 year-old woman in the third trimester of pregnancy was admitted for severe acute pancreatitis due to hypertriglyceridemia. During hospitalization she developed multiorgan dysfunction, infected pancreatic necrosis, abdominal compartment syndrome and intrauterine fetal death. She was successfully treated by multidisciplinary team including department of emergency medicine, ICU, gastroenterology, obstetrics, endocrinology, ultrasonography, radiology, infectious disease, nutrition and surgery. Read More

    Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1.
    JIMD Rep 2017 Feb 4. Epub 2017 Feb 4.
    Division of Endocrinology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
    Background: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles. We describe hypogonadotropic hypogonadism as a novel complication in glycogen storage disease (GSD) type 1. Read More

    Interlinkage among cardio-metabolic disease markers in an urban poor setting in Nairobi, Kenya.
    Glob Health Action 2016 Jan;9(1):30626
    a African Population and Health Research Center Nairobi , Kenya.
    Introduction The main cardio-metabolic diseases - mostly cardiovascular diseases such as stroke and ischemic heart disease - share common clinical markers such as raised blood pressure and blood glucose. The pathways of development of many of these conditions are also interlinked. In this regard, a higher level of co-occurrence of the main cardio-metabolic disease markers is expected. Read More

    Omega-3 polyunsaturated fatty acid profiles and relationship with cardiometabolic risk factors in Cree (Eeyouch) of Northern Québec.
    Int J Circumpolar Health 2016 Jan;75(1):30361
    a Population Health and Optimal Health Practices Research Unit CHU de Québec Research Centre , Québec , QC , Canada.
    Background n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) from fish are known modulators of cardiometabolic risk factors. Objective To examine fatty acids (FAs) status and the relationship between n-3 LC-PUFA and cardiometabolic risk factors in Cree participants. Design We analyzed data from a cross-sectional study (n=829) conducted in Cree adults (aged 18-74 years) from 7 communities of the James Bay territory of Quebec (Canada) in 2005-2009. Read More

    [Lipid and glucose profile in patients with ischemic cerebrovascular accidents in Dakar].
    Pan Afr Med J 2016 27;25:29. Epub 2016 Sep 27.
    Clinique Neurologique du Centre Hospitalier Universitaire de Fann-Dakar, Sénégal.
    Cerebrovascular accident (CVA) is defined as the rapid development of localized or global clinical signs of neurological dysfunction with no apparent cause other than that of vascular origin. A variety of risk factors have been identified and associated with the occurrence of Ischemic CVA, including glucose and lipid metabolism disturbances. We conducted a retrospective study at the Clinic of Neurology, Fann. Read More

    Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Upregulation of E3 Ubiquitin-protein Ligase RNF216.
    J Biol Chem 2017 Feb 1. Epub 2017 Feb 1.
    Kyushu University, Japan;
    Toll-like receptor 4 (TLR4) plays an essential role in innate immunity through inflammatory cytokine induction. Recent studies demonstrated that the abnormal activation of TLR4 has a pivotal role in obesity-induced inflammation, which is associated with several diseases, including hyperinsulinemia, hypertriglyceridemia, and cardiovascular disease. Here we demonstrate that (-)-epigallocatechin-3-O-gallate, a natural agonist of the 67-kDa laminin receptor (67LR), suppressed TLR4 expression through E3 ubiquitin-protein ring finger protein 216 (RNF216) upregulation. Read More

    Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.
    Arterioscler Thromb Vasc Biol 2017 Feb 2. Epub 2017 Feb 2.
    From the Robarts Research Institute (J.P.S., A.C.B., B.G.S., D.E.T., C.G.S., J.Y.E., M.W.H.), Department of Biochemistry (J.P.S., A.C.B., M.W.H.), and Department of Medicine (D.E.T., C.G.S., J.Y.E., M.W.H.), The University of Western Ontario, London, Canada; and Esperion Therapeutics Inc, Ann Arbor, MI (S.L.P., R.S.N.).
    Objective: Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol-lowering compound. In animals, bempedoic acid targets the liver where it inhibits cholesterol and fatty acid synthesis through inhibition of ATP-citrate lyase and through activation of AMP-activated protein kinase. In this study, we tested the hypothesis that bempedoic acid would prevent diet-induced metabolic dysregulation, inflammation, and atherosclerosis. Read More

    Serum total bilirubin levels are negatively correlated with metabolic syndrome in aged Chinese women: a community-based study.
    Braz J Med Biol Res 2017 Jan 26;50(2):e5252. Epub 2017 Jan 26.
    Pingliang Community Health Service Centers, Yangpu Area, Shanghai, China.
    We evaluated serum total bilirubin levels as a predictor for metabolic syndrome (MetS) and investigated the relationship between serum total bilirubin levels and MetS prevalence. This cross-sectional study included 1728 participants over 65 years of age from Eastern China. Anthropometric data, lifestyle information, and previous medical history were collected. Read More

    Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology.
    Sci Rep 2017 Jan 31;7:41711. Epub 2017 Jan 31.
    School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.
    We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain the pharmacological effects of ESB by integrating gene expression information from db/db mouse liver with that of ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (cmap) analysis, we found an inverse relationship in the pharmaceutical profiles based on gene expression between db/db mouse liver and ESB-treated HepG2 cells. Read More

    Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA).
    Lipids Health Dis 2017 Jan 31;16(1):23. Epub 2017 Jan 31.
    Department of Medicine, Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA and Elucida Research LLC, PO Box 7100, Beverly, MA, 01915-6127, USA.
    The omega-3 fatty acid eicosapentaenoic acid (EPA) has multiple actions potentially conferring cardiovascular benefit, including lowering serum triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels and potentially reducing key steps in atherogenesis. Dietary supplements are a common source of omega-3 fatty acids in the US, but virtually all contain docosahexaenoic acid (DHA) in addition to EPA, and lipid effects differ between DHA and EPA. Contrary to popular belief, no over-the-counter omega-3 products are available in the US, only prescription products and dietary supplements. Read More

    Secular Trend of Metabolic Syndrome and Its Components in a Cohort of Iranian Adults from 2001 to 2013.
    Metab Syndr Relat Disord 2017 Jan 30. Epub 2017 Jan 30.
    1 School of Medicine and Menzies Health Institute, Griffith University , Southport, Queensland, Australia .
    Background: Metabolic syndrome (MetS) and its components increase the risk of developing cardiovascular diseases, type 2 diabetes, and all-cause mortality. Reports on the trends of MetS and its components in longitudinal studies are scarce, especially in low- and middle-income countries. This study was designed to investigate the prevalence and trends of MetS and its components in a cohort of Iranian adults from 2001 to 2013. Read More

    Risk of incident ischemic stroke according to the metabolic health and obesity states in the Vascular-Metabolic CUN cohort.
    Int J Stroke 2017 Feb 22;12(2):187-191. Epub 2016 Oct 22.
    3 University of Navarra.
    Background Whether obesity is a major risk factor for cardiovascular disease in the absence of metabolic comorbidities remains under debate. Indeed, some obese individuals may be at low risk of metabolic-related complications, while normal-weight individuals may not be "healthy." Aims To assess the incidence of ischemic stroke according to the metabolic health and obesity states of 5171 participants from the Vascular-Metabolic CUN cohort. Read More

    Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure.
    Br J Nutr 2017 Jan 30;117(2):177-186. Epub 2017 Jan 30.
    1Department of Biotechnology,BK21-PLUS,College of Life Sciences & Biotechnology,Korea University,Seoul 02841,Republic of Korea.
    Hyperlipidaemia is a major cause of atherosclerosis and related CVD and can be prevented with natural substances. Previously, we reported that a novel Bacillus-fermented green tea (FGT) exerts anti-obesity and hypolipidaemic effects. This study further investigated the hypotriglyceridaemic and anti-obesogenic effects of FGT and its underlying mechanisms. Read More

    Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.
    Toxicology 2017 Mar 25;379:12-21. Epub 2017 Jan 25.
    Department of Health Sciences, College of Public Health, East Tennessee State University, Johnson City, TN, United States; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States. Electronic address:
    Background & Aims: Cytochrome P450 2A5 (CYP2A5) is induced by ethanol, and the ethanol induction of CYP2A5 is regulated by nuclear factor-erythroid 2-related factor 2 (NRF2). Cyp2a5 knockout (Cyp2a5(-/-)) mice develop more severe alcoholic fatty liver than Cyp2a5(+/+) mice. Fibroblast growth factor 21 (FGF21), a PPARα-regulated liver hormone, is involved in hepatic lipid metabolism. Read More

    Marked hypertriglyceridemia induced by interferon-β1a therapy in a clinically isolated syndrome patient.
    J Neurol Sci 2017 Feb 27;373:144-146. Epub 2016 Dec 27.
    Department of Neurology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Electronic address:

    Cardiovascular consequences of metabolic syndrome.
    Transl Res 2017 Jan 9. Epub 2017 Jan 9.
    Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Ind; Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind.
    The metabolic syndrome (MetS) is defined as the concurrence of obesity-associated cardiovascular risk factors including abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, decreased HDL cholesterol, and/or hypertension. Earlier conceptualizations of the MetS focused on insulin resistance as a core feature, and it is clearly coincident with the above list of features. Each component of the MetS is an independent risk factor for cardiovascular disease and the combination of these risk factors elevates rates and severity of cardiovascular disease, related to a spectrum of cardiovascular conditions including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. Read More

    Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies.
    PLoS One 2017 27;12(1):e0170971. Epub 2017 Jan 27.
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
    Background: Pathophysiological investigation of disease in a suitable animal model is a classical approach towards development of a credible therapeutic strategy. This study examined appropriate insulin level in selecting animal model for type 2 diabetes (T2D) studies.

    Method: Albino Wistar rats (150-200g) were divided into two groups fed with commercially available normal-diet-feed (NDF) and water or fortified diet feed (FDF) (10g NDF per gram of margarine) with 20% fructose solution as drinking water. Read More

    [Hyperlipoproteinemia and dyslipidemia as rare diseases. Diagnostics and treatment].
    Vnitr Lek 2016 ;62(11):887-894
    Hyperlipoproteinemia (HLP) and dyslipidemia (DLP) are of course mainly perceived as diseases of common incidence and are typically seen as the greatest risk factors (RF) in the context of the pandemic of cardiovascular diseases. This is certainly true and HLP or DLP overall affect tens of percents of adults. However we cannot overlook the fact that disorders (mostly congenital) of lipid metabolism exist which, though not formally defined as such, amply satisfy the conditions for classification as rare diseases. Read More

    High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.
    J Immunol Res 2017 3;2017:3972706. Epub 2017 Jan 3.
    Department of Dermatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
    Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. Read More

    The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis.
    Endocrinol Metab (Seoul) 2017 Jan 19. Epub 2017 Jan 19.
    Department of Molecular Medicine, Inha University School of Medicine, Incheon, Korea.
    Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis in insulin-resistant states. Read More

    APOC3 Is Not a Predisposing Factor for Fat-Induced Nonalcoholic Fatty Liver Disease in Mice.
    J Biol Chem 2017 Jan 23. Epub 2017 Jan 23.
    University of Pittsburgh School of Medicine, United States
    Nonalcoholic fatty liver disease (NAFLD), characterized by excessive fat accumulation in liver, is prevalent in obesity. Genetic factors that link obesity to NAFLD remain obscure. Apolipoprotein C3 (APOC3) is a lipid-binding protein with a pivotal role in triglyceride metabolism. Read More

    Identifying Cardiovascular Risk in Survivors of Childhood Leukaemia Treated with Haematopoietic Stem Cell Transplantation and Total Body Irradiation
    Horm Res Paediatr 2017 Jan 23. Epub 2017 Jan 23.
    Background: Survivors of childhood with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have an increased cardiometabolic risk without overt obesity.

    Aim: To describe cardiometabolic risk in HSCT/TBI survivors and identify anthropometric measurements of adiposity representative of cardiometabolic risks in HSCT/TBI survivors.

    Method: Childhood leukaemia survivors treated with HSCT/TBI (n = 21, 11 males) were compared with chemotherapy-only (n = 31) and obese non-leukaemic controls (n = 30). Read More

    Impact of treatment with TNF antagonists on total cholesterol in patients with ankylosing spondylitis and psoriatic arthritis.
    Clin Rheumatol 2017 Jan 20. Epub 2017 Jan 20.
    Rheumatology Department, Complejo Hospitalario Universitario de Santiago de Compostela, c/ Travesía da Choupana s/n, 15706, Santiago de Compostela, Spain.
    The objective of the study was to analyze the impact of TNF antagonists (TNFa) on the total cholesterol and triglycerides on ankylosing spondylitis (AS) and psoriatic arthritis (PsA). In this single-centre observational study of AS and PsA patients, differences in triglyceride and total cholesterol levels and frequency of hypertriglyceridemia and hypercholesterolemia at 3 and 6 months were analysed in patients treated and not treated with TNFa. General estimation equations and linear regression analysis were used to investigate associations between disease activity and lipid levels and to identify predictors of change. Read More

    Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients.
    PLoS One 2017 20;12(1):e0169939. Epub 2017 Jan 20.
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
    Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Apolipoprotein C-II (APOC2) is an obligatory cofactor for lipoprotein lipase (LPL), the major enzyme catalyzing plasma triglyceride hydrolysis. We have created an apoc2 knockout zebrafish model, which mimics the familial chylomicronemia syndrome (FCS) in human patients with a defect in the APOC2 or LPL gene. Read More

    Racial and Ethnic Differences in the Polycystic Ovary Syndrome (PCOS) Metabolic Phenotype.
    Am J Obstet Gynecol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO.
    Background: Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome amongst women with polycystic ovarian syndrome is important for prevention strategies. Read More

    What is the appropriate strategy for diagnosing NAFLD using ultrasonography in obese children?
    World J Pediatr 2017 Jan 19. Epub 2017 Jan 19.
    Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Kyounggido, Korea.
    Background: The aim of this study is to identify obese children who are candidates for a potential diagnosis of non-alcoholic fatty liver disease (NAFLD).

    Methods: We enrolled 242 obese children (122 boys and 120 girls) aged 7-16 years who were examined with abdominal ultrasonography in our pediatric obesity clinic. We compared patients in the normal group with those in the NAFLD group (mild disease, moderate to severe disease) and identified the optimal anthropometric parameters among height, weight, body mass index (BMI), waist circumference, hip circumference, waist to height ratio (WHtR), and waist to hip ratio to predict NAFLD using a receiver operating characteristic curve analysis. Read More

    Postexercise repletion of muscle energy stores with fructose or glucose in mixed meals.
    Am J Clin Nutr 2017 Jan 18. Epub 2017 Jan 18.
    Department of Physiology, University of Lausanne, Lausanne, Switzerland; and
    Background: Postexercise nutrition is paramount to the restoration of muscle energy stores by providing carbohydrate and fat as precursors of glycogen and intramyocellular lipid (IMCL) synthesis. Compared with glucose, fructose ingestion results in lower postprandial glucose and higher lactate and triglyceride concentrations. We hypothesized that these differences in substrate concentration would be associated with a different partition of energy stored as IMCLs or glycogen postexercise. Read More

    The Prevalence of Nonalcoholic Fatty Liver Disease and Related Metabolic Comorbidities Was Associated with Age at Onset of Moderate to Severe Plaque Psoriasis: A Cross-Sectional Study.
    PLoS One 2017 18;12(1):e0169952. Epub 2017 Jan 18.
    Department of Dermatology, Shanghai Dermatology Hospital, Shanghai, China.
    Nonalcoholic fatty liver disease (NAFLD) has been found to be highly prevalent in psoriatic patients. Adult onset psoriasis could be divided into either early or late onset psoriasis. The associations between NAFLD and related metabolic comorbidities and age at onset of psoriasis have not yet been investigated. Read More

    Metreleptin Treatment in Three Patients with Generalized Lipodystrophy.
    Clin Med Insights Case Rep 2016 5;9:123-127. Epub 2017 Jan 5.
    Mayo Clinic, Rochester, MN, USA.
    Generalized lipodystrophy (GL) is a rare inherited or acquired disease characterized by widespread loss of subcutaneous fat, leading to leptin deficiency, ectopic fat deposition, and severe metabolic abnormalities. Previous studies have shown the benefit of leptin replacement (metreleptin) in ameliorating metabolic complications, but little is known about the experience of metreleptin treatment outside of a research setting. We report on post-marketing clinical experience with metreleptin therapy in three patients with GL and marked hypoleptinemia, uncontrolled diabetes, and hypertriglyceridemia. Read More

    Angiotensin II induces differential insulin action in rat skeletal muscle.
    J Endocrinol 2017 Mar 17;232(3):547-560. Epub 2017 Jan 17.
    Exercise Physiology LaboratoryDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Angiotensin II (ANGII) is reportedly involved in the development of skeletal muscle insulin resistance. The present investigation evaluated the effects of two ANGII doses on the phenotypic characteristics of insulin resistance syndrome and insulin action and signaling in rat skeletal muscle. Male Sprague-Dawley rats were infused with either saline (SHAM) or ANGII at a commonly used pressor dose (100 ng/kg/min; ANGII-100) or a higher pressor dose (500 ng/kg/min; ANGII-500) via osmotic minipumps for 14 days. Read More

    Secondary haemophagocytic lymphohistiocytosis triggered by postnatally acquired cytomegalovirus infection in a late preterm infant.
    Infection 2017 Jan 16. Epub 2017 Jan 16.
    Children's Hospital, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.
    Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition with impairment of cytotoxic T-cells and natural killer cells. Causes in infants are mostly hereditary immune defects as well as various infectious triggering factors, amongst these cytomegalovirus (CMV). Vertical CMV transmission may occur in utero, during birth, and by breast feeding. Read More

    Adipocyte and epidermal fatty acid-binding protein serum concentrations in patients with lipodystrophy.
    Cytokine 2017 Jan 12;92:20-23. Epub 2017 Jan 12.
    Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany.
    Objective: Lipodystrophy (LD) syndromes are associated with diabetes mellitus, hypertriglyceridemia, and coronary artery disease. One pathogenetic factor of LD is dysregulation of several adipokines. However, the insulin resistance- and dyslipidemia-promoting adipokines adipocyte (AFABP) and epidermal (EFABP) fatty acid-binding protein have not been investigated in non-HIV-associated LD so far. Read More

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