15,866 results match your criteria Hypertriglyceridemia


NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with postprandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density-lipoproteins (HDL-TG), and subsequent HDL-dysfunction. We assessed liver fat by MR-spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following 3 consecutive meals, in 36 men with type 2 diabetes (T2DM), with the MetS, and controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14597DOI Listing

Evaluation of the Chylomicron-TG to VLDL-TG ratio for Type I Hyperlipoproteinemia diagnostic.

Eur J Clin Invest 2020 Jul 10:e13345. Epub 2020 Jul 10.

Department of Medicine and Dermatology, Lipids and Atherosclerosis Laboratory. Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Spain.

Background: The aim of this study is to confirm the diagnostic performance of the Chylomicron to Very Low Density Lipoproteins Triglycerides (CM/VLDL-TG) ratio, the Triglycerides to Cholesterol ratio (TG/TC) and a dichotomic rule including the Tryglicerides to Apolipoprotein B (TG/APOB) ratio for the presence of Type I Hyperlipoproteinemia (HPLI) in patients with severe hypertriglyceridemia (sHTG) that were at high risk for Familial Chylomicronemia Syndrome (FCS).

Methods: Two cohorts (Derivation and Validation) of patients with sHTG were included in the study. Anthropometric, clinical, biochemical and genetic data were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13345DOI Listing

Berardinelli-Seip Syndrome and Essential Thrombocytosis: An Unusual Association.

Oman Med J 2020 May 30;35(3):e135. Epub 2020 Jun 30.

Department of Internal Medicine, Endocrine Division, King Hussein Medical Centre, Amman, Jordan.

Congenital generalized lipodystrophy (Berardinelli-Seip syndrome) is an autosomal recessive condition, presenting during infancy with generalized loss of fat. We report a 30-year-old female patient with diabetes who has acromegaloid features, prominent umbilicus, prominent muscles, prominent subcutaneous veins, and gross hepatomegaly. Near-total loss of subcutaneous fat was confirmed by whole-body magnetic resonance imaging and laboratory data revealed significant hypertriglyceridemia, uncontrolled diabetes mellitus, and heavy proteinuria with stage IIIa chronic kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5001/omj.2020.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335454PMC

Evaluation of efficacy and safety of antisense inhibition of apolipoprotein C-III with volanesorsen in patients with severe hypertriglyceridemia.

Expert Opin Pharmacother 2020 Jul 10:1-10. Epub 2020 Jul 10.

Department of Translational and Precision Medicine, Sapienza University of Rome , Rome, Italy.

Introduction: Severe hypertriglyceridemia (sHTG) is a complex disorder of lipid metabolism characterized by plasma levels of triglyceride (TG) greater than 885 mg/dl (>10 mmol/L). The treatment of sHTG syndromes is challenging because conventional treatments are often ineffective in reducing TG under the threshold to prevent acute pancreatitis (AP). The inhibition of , which encodes a protein involved in triglyceride (TG)-rich lipoproteins (TGRLs) removal, has been reported to be a novel target for the treatment of sHTG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2020.1787380DOI Listing

Prevalence of non-communicable diseases among individuals with HIV infection by antiretroviral therapy status in Dar es Salaam, Tanzania.

PLoS One 2020 9;15(7):e0235542. Epub 2020 Jul 9.

Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Background: Long-term antiretroviral therapy has modified the clinical course of HIV infection to a chronic condition associated with increased risk of developing non-communicable diseases (NCDs). Information is scant, from sub-Saharan Africa, on the prevalence of NCDs and associated factors among individuals on ART.

Methodology: We consecutively enrolled individuals with HIV infection who were ART naïve and those on ART for ≥5 years (LTART) attending health facilities in Dar es Salaam. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235542PLOS

The Efficacy of Intravenous Insulin Infusion in the Management of Hypertriglyceridemia-Induced Pancreatitis in a Rural Community Hospital.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620940492

White River Health System, Batesville, AR, USA.

A 28-year-old female presented to the emergency room with epigastric pain, nausea, and vomiting; her lipase was elevated, and computed tomography of abdomen showed evidence of acute pancreatitis. Her past medical history was significant for poorly controlled insulin requiring type 2 diabetes mellitus and 2 previous admissions for hypertriglyceridemia-induced pancreatitis. Due to the severity of her pancreatitis presentation, she was admitted to the intensive care unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620940492DOI Listing

Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress.

Inflammation 2020 Jul 9. Epub 2020 Jul 9.

Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China.

Hypertriglyceridemia (HTG) can aggravate acute pancreatitis (AP), but its pathogenesis remains unclear. As autophagic activity is closely related to lipid metabolism and AP, we investigated the autophagic response in models of AP aggravated by HTG and explored whether rapamycin has a protective effect against HTG-related pancreatitis. HTG-associated AP models were established in vivo in rats and in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10753-020-01228-7DOI Listing

Pediatric Dyslipidemia-Beyond Familial Hypercholesterolemia.

Can J Cardiol 2020 Mar 23. Epub 2020 Mar 23.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address:

Dyslipidemia is seen with increasing prevalence in young Canadians, mainly mild to moderate hypertriglyceridemia secondary to obesity. This review focuses on pediatric dyslipidemias excluding familial hypercholesterolemia (FH), but including both severe and mild to moderate hypertriglyceridemia, combined hyperlipidemia, and elevated lipoprotein(a) [Lp(a)]. We suggest that for Canadian children and adolescents with dyslipidemia, atherosclerotic cardiovascular disease (ASCVD) risk assessment should include both low-density lipoprotein cholesterol and triglycerides measurement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2020.03.020DOI Listing

PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome.

Nutr Metab Cardiovasc Dis 2020 May 28. Epub 2020 May 28.

Molecular Genetics of Complex Phenotypes Research Unit, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy. Electronic address:

Background And Aims: We previously demonstrated that children with Down syndrome (DS) exhibited a greater risk of steatosis than the general pediatric population. This trend was independent of obese phenotype, thus suggesting a role of genetic predisposition. Therefore, we investigated the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in function of genetic susceptibility and adipocytokine levels in children with DS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.numecd.2020.05.012DOI Listing

The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study.

J Trace Elem Med Biol 2020 Jun 30;62:126601. Epub 2020 Jun 30.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam College of Medicine, Daegu, Republic of Korea. Electronic address:

Aim: The potential effects of heavy metals on non-alcoholic fatty liver disease (NAFLD) remain unknown. We investigated the sex-specific relationships of blood lead (BPb), mercury (BHg), and cadmium (BCd) levels with hepatic steatosis (HS) and fibrosis (HF).

Method: We included 4420 participants from the 2016-2017 Korea National Health and Nutrition Examination Survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2020.126601DOI Listing

Evaluation of Maternal Reproductive Outcomes and Biochemical Analysis from Wistar Audiogenic Rats (WAR) and Repercussions in Their Offspring.

Reprod Sci 2020 Jul 6. Epub 2020 Jul 6.

Tocogynecology Postgraduate Course, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

The objective of the present study was to evaluate maternal reproductive performance, body weight, and frequency of external and internal anomalies of newborns of Wistar Audiogenic Rat (WAR) females as compared with Wistar rats. The adult WAR and Wistar rats were mated within their respective strains. After confirming the pregnancy, the body weights were weekly evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s43032-020-00236-0DOI Listing

Identifying endemic areas and estimating the prevalence of hyperlipidemia in Taiwan's townships.

J Formos Med Assoc 2020 Jul 3. Epub 2020 Jul 3.

Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan. Electronic address:

Background/purpose: This study aimed to evaluate geographic variations and differences in the prevalence of hypertriglyceridemia and hypercholesterolemia between Taiwan's townships.

Methods: The prevalence of hypertriglyceridemia and hypercholesterolemia was evaluated according to the geographic characteristics of the people in the Adult Preventive Service Program from 2009 to 2010. The prevalence of hypertriglyceridemia and hypercholesterolemia in 2009 and 2010 was used and divided into three groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfma.2020.05.031DOI Listing

The role of double filtration plasmapheresis in hypertriglyceridemic pancreatitis: A propensity score matching analysis.

J Clin Apher 2020 Jul 6. Epub 2020 Jul 6.

Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: The role of double filtration plasmapheresis (DFPP) in hypertriglyceridemic pancreatitis (HTGP) is still not well established. Our study aimed to investigate the efficacy of DFPP in reducing triglyceride levels as well as their effects on the outcomes of HTGP.

Material And Methods: We retrospectively evaluated the data of patients with HTGP presenting within 72 hours from symptom onset between January 2016 and February 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21811DOI Listing

Blood levels of perfluoroalkyl substances (PFASs), elements and their associations with metabolic syndrome (MetS) in Chinese male adults mediated by metabolic-related risk factors.

Sci Total Environ 2020 Jun 29;742:140595. Epub 2020 Jun 29.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China. Electronic address:

Our preliminary studies have suggested PFASs, heavy metals, and trace elements could bring significant risks to MetS. However, the role of epigenetic mechanisms (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.140595DOI Listing

Tumorigenic Potential of Granulocyte Colony-Stimulating Factor Therapy-A Case Report and Review of Literature.

J Oral Maxillofac Surg 2020 Jun 10. Epub 2020 Jun 10.

Assistant Professor of Surgery and Residency Program Director, Department of Oral and Maxillofacial Surgery, Parkland/UT Southwestern, Dallas, TX.

An association between granulocyte colony-stimulating factor therapy (G-CSFT) in patients with glycogen storage disease type Ib (GSDIb) and the development of giant cell lesions of the maxillofacial complex has emerged. We have reported, to the best of our knowledge, the fourth case of giant cell granuloma (GCG) in a patient with GSDIb undergoing G-CSFT. GSDIb can present with hypoglycemia, hypertriglyceridemia, and neutropenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2020.06.006DOI Listing

Genetic analysis and long-term treatment monitoring of 11 children with glycogen storage disease type IIIa.

J Pediatr Endocrinol Metab 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030,China.

Objectives To investigate the clinical and genetic characteristics of children with glycogen storage disease type IIIa (GSD IIIa) and to explore the muscle involvement and manifestations of GSD IIIa patients. Methods The clinical data of 11 patients with GSD IIIa diagnosed by genetic testing from 2003 to 2019 were retrospectively analyzed. Results Twenty variants of AGL gene were detected in 11 patients, eight of which were novel variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jpem-2019-0453DOI Listing

Plasmapheresis Treatment of Hypertriglyceridemia-Induced Acute Pancreatitis: A Case Report.

Cureus 2020 May 30;12(5):e8360. Epub 2020 May 30.

Pulmonary Critical, Richmond University Medical Center, Staten Island, USA.

Hypertriglyceridemia is the third most common etiology for acute pancreatitis (AP), after alcohol and gallstones. Clinical evidence is relatively weak in its support of plasmapheresis for the treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP). We report a case of severe HTG-AP in a young man who was successfully treated with plasmapheresis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325388PMC

Lipid profile assessed in the family pediatrician's office: the COLIBRI'- SIMPeF study.

Eur J Pediatr 2020 Jul 2. Epub 2020 Jul 2.

School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, MB, Italy.

There is limited information on the prevalence of dyslipidemia in the Italian pediatric population. Aim of the study was to evaluate total cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride levels, and associated factors in a large sample of Italian children, applying a micro-sampling procedure in the family pediatrician's office. In a population of 1910 children (50. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-020-03726-0DOI Listing

A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders.

Diabetes 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 U.S.A.;

Targeting rexinoid X receptor (RXR) has been proposed as one of the therapeutic strategies to treat individuals with metabolic syndrome, because RXR heterodimerizes with multiple nuclear receptors that regulate genes involved in metabolism. Despite numerous efforts, RXR ligands (rexinoids) have not been approved for clinical trials to treat metabolic syndrome due to the serious side effects such as hypertriglyceridemia and altered thyroid hormone axis. Herein, we demonstrate a novel rexinoid-like small molecule, UAB126, which has positive effects on metabolic syndrome without the known side effects of potent rexinoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db19-1001DOI Listing

Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Programa de Pós-Graduação em Nutrição, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.

Objective: To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. The moderator role of 25(OH)D in the association of MetS, its diagnostic components and IR with hsCRP were also explored.

Materials And Methods: A cross-sectional study (2014/2015) with a population-based cohort in Southern Brazil (n = 605). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20945/2359-3997000000272DOI Listing

A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.

Cureus 2020 May 26;12(5):e8299. Epub 2020 May 26.

U. O. C. Di Medicina Generale E Lungodegenza, San Giovanni Bosco Hospital, Asl Napoli 1 Centro, Naples, ITA.

A 24-year-old obese Caucasian male, without relevant anamnesis, who was admitted to the ER presented with abdominal pain, nausea and vomiting, hyperglycemia, and diabetic ketoacidosis (DKA). The diagnosis of acute pancreatitis (AP) was supported by increased serum levels of triglycerides and lipase associated with abdominal CT scans. The patient was treated for five days with IV regular insulin, hydration, electrolytes replacement, and statin/fibrate therapy with clinical improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320639PMC

Hyperglycemia, Hypertriglyceridemia, and Acute Pancreatitis in COVID-19 Infection: Clinical Implications.

Pancreas 2020 Jun 23. Epub 2020 Jun 23.

Division of Gastroenterology Hepatology and Clinical Nutrition Saint Peter's University Hospital New Brunswick, NJ Department of Medicine Saint Peter's University Hospital New Brunswick, NJ Division of Gastroenterology and Hepatology Montifiore Medical Center Bronx, NY Division of Gastroenterology Hepatology and Clinical Nutrition Saint Peter's University Hospital New Brunswick,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPA.0000000000001595DOI Listing

Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue.

J Dev Orig Health Dis 2020 Jun 29:1-12. Epub 2020 Jun 29.

Laboratory of Experimental Physiology (LeFisio), Department of Physiological Sciences, Federal University of Maranhão (UFMA), São Luís, MA, Brazil.

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) particularly among chronic consumers of added sugar-rich diets. However, the impact of early consumption of such diets on NAFLD onset and progression is unclear. Thus, this study sought to characterise metabolic factors involved in NAFLD progression in young mice fed with a high-sucrose diet (HSD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S2040174420000598DOI Listing

Fundoscopic characteristics in three cases of familial hyperchylomicronaemia.

Arch Soc Esp Oftalmol 2020 Jun 24. Epub 2020 Jun 24.

Servicio de Oftalmología. Hospital Universitario Virgen del Rocío, Sevilla, España.

Cases Report: Three cases are presented of patients with familial hyperchylomicronaemia and lipaemia retinalis, in whom an analysis is made of the fundoscopic characteristics of each of them.

Discussion: The typical appearance of the retinal fundus is pale salmon coloured and corresponds to levels of severe lipaemia retinalis. As regards the findings, the vascular tree tonality is probably the best exploratory evidence to help in the ophthalmological diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2020.05.025DOI Listing

The Effect of Smoking on the Association between Long-Term Alcohol Consumption and Dyslipidemia in a Middle-Aged and Older Population.

Alcohol Alcohol 2020 Jun 26. Epub 2020 Jun 26.

Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea.

Aims: The joint effects of chronic alcohol consumption and smoking on dyslipidemia remain unclear in a prospective design. This study examined the effect of smoking on the association between long-term alcohol consumption and risk of incident dyslipidemia.

Methods: A total of 4467 participants (1866 men and 2601women) aged 40-69 years without dyslipidemia were recruited at baseline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/alcalc/agaa051DOI Listing

A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.

PLoS One 2020 25;15(6):e0235362. Epub 2020 Jun 25.

Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: Cardiovascular disease is a leading cause of death worldwide. Obesity-related metabolic disorders including dyslipidemia cause impaired collateralization under ischemic conditions, thereby resulting in exacerbated cardiovascular dysfunction. Pemafibrate is a novel selective PPARα modulator, which has been reported to improve atherogenic dyslipidemia, in particular, hypertriglyceridemia and low HDL-cholesterol. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316279PMC

Fenofibrate-induced renal dysfunction, yes or no?

J Res Med Sci 2020 13;25:39. Epub 2020 Apr 13.

Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

In the treatment process of hypertriglyceridemia and diabetic nephropathy in type 2 diabetes, fenofibrate (FEN) is a well-known medication. FEN is from fibrate class drugs that using orally; however, as a side effect, it is associated with serum creatinine level increasing. The aim of this review was to determine the real effect of FEN therapy on renal functions based on both experimental and clinical studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jrms.JRMS_772_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306240PMC

Loss-of-Function Variants in Patients With Severe Hypertriglyceridemia.

Arterioscler Thromb Vasc Biol 2020 Jun 25:ATVBAHA120314168. Epub 2020 Jun 25.

From the Robarts Research Institute, Western University, London, ON, Canada (J.S.D., A.A.D., A.L., A.D.M., J.W., H.C., R.A.H.).

Objective: Genetic determinants of severe hypertriglyceridemia include both common variants with small effects (assessed using polygenic risk scores) plus heterozygous and homozygous rare variants in canonical genes directly affecting triglyceride metabolism. Here, we broadened our scope to detect associations with rare loss-of-function variants in genes affecting noncanonical pathways, including those known to affect triglyceride metabolism indirectly. Approach and Results: From targeted next-generation sequencing of 69 metabolism-related genes in 265 patients of European descent with severe hypertriglyceridemia (≥10 mmol/L or ≥885 mg/dL) and 477 normolipidemic controls, we focused on the association of rare heterozygous loss-of-function variants in individual genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.120.314168DOI Listing

Metabolic Complications Occur More Frequently in Older Patients Receiving Parenteral Nutrition.

Nutr Clin Pract 2020 Aug 24;35(4):627-633. Epub 2020 Jun 24.

Department of Pharmacy, Cooper University Hospital, Camden, New Jersey, USA.

Background: The European Society for Clinical Nutrition and Metabolism Guidelines for Parenteral Nutrition in Geriatric Patients state metabolic complications are more frequent in elderly patients. However, literature provides limited information about metabolic complications in older patients receiving parenteral nutrition (PN). Consequently, the purpose of this study was to compare the development of metabolic complications in older vs younger patients receiving PN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ncp.10499DOI Listing
August 2020
2.058 Impact Factor

Association between atherogenic dyslipidemia and fournier's gangrene.

Rev Assoc Med Bras (1992) 2020 Apr;66(4):479-484

. Department of Urology, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Objective: We aimed to determine whether atherogenic dyslipidemia is associated with the disease and morbidity in our patients treated for Fournier's gangrene (FG).

Methods: Sixty-two patients who were treated with the diagnosis of FG at our center between 2012 and 2017 were retrospectively screened.

Results: The triglyceride values of the patients who required reconstructive surgery were statistically significantly higher than those of the patients for whom wound debridement and primary suturing was sufficient (p:0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1806-9282.66.4.479DOI Listing

Ph myeloproliferative neoplasms and the related risk factors for stroke occurrence: Results from a registry of patients treated with Anagrelide.

J Thromb Thrombolysis 2020 Jun 23. Epub 2020 Jun 23.

University Hospital Hradec Králové, Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic.

Arterial thrombosis is a common complication in patients with Ph myeloproliferative neoplasms (MPN). We searched for the risk factors of stroke in MPN patients from anagrelide registry. We analyzed the potential risk factors triggering a stroke/TIA event in 249 MPN patients with previous stroke (n = 168) or Transient Ischemic Attack (TIA) (n = 140), and in 1,193 MPN control subjects (without clinical history of thrombosis). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-020-02175-8DOI Listing

A proprotein convertase subtilisin/kexin type 9 inhibitor provides comparable efficacy with lower detriment than statins on mitochondria of oxidative muscle of obese estrogen-deprived rats.

Menopause 2020 Jun 22. Epub 2020 Jun 22.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: The aim of the study was to compare the effects of atorvastatin, a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i), and 17β-estradiol on oxidative muscle mitochondria in a model of menopause with obesity.

Methods: Female Wistar rats consumed either a standard diet (n = 12) or a high-fat/calorie diet (HFCD: n = 60). At week 13, standard diet-fed rats underwent a sham operation, whereas HFCD-fed rats underwent either a sham operation (n = 12) or an ovariectomy (n = 48). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GME.0000000000001586DOI Listing

Hypertriglyceridemia and acute pancreatitis.

Pancreatology 2020 Jun 12. Epub 2020 Jun 12.

Division of Gastroenterology, Hepatology & Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Hypertriglyceridemia is the third most common cause of acute pancreatitis. It typically occurs in patients with an underlying disorder of lipoprotein metabolism and in the presence of a secondary condition such as uncontrolled diabetes, alcohol abuse, or medication use. The presentation of hypertriglyceridemia-induced pancreatitis is similar to that of acute pancreatitis due to other causes; however, patients with hypertriglyceridemia-induced pancreatitis are more likely to have severe disease courses and have a higher likelihood of persistent organ failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pan.2020.06.005DOI Listing

Twelve months of exercise training did not halt abdominal aortic calcification in patients with CKD - a sub-study of RENEXC-a randomized controlled trial.

BMC Nephrol 2020 Jun 22;21(1):233. Epub 2020 Jun 22.

Department of Clinical Sciences Lund, Nephrology, Lund, Sweden, Lund University, Skåne University Hospital, Alwallhuset Barngatan 2A, 121 85, Lund, Sweden.

Background: Arteriosclerosis is prevalent in patients with chronic kidney disease (CKD). Our aims were to investigate (1) the effects of 12 months of either balance- or strength- both in combination with endurance training on abdominal aortic calcification (AAC); on some lipids and calcific- and inflammatory markers; and (2) the relationships between the change in AAC score and these markers in non-dialysis dependent patients with CKD stages 3 to 5.

Methods: One hundred twelve patients (mean age 67 ± 13 years), who completed 12 months of exercise training; comprising either balance- or strength training, both in combination with endurance training; with a measured glomerular filtration rate (mGFR) 22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01881-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310004PMC

Pharmacokinetics of Single and Multiple Doses of Omega-3 Carboxylic Acids in Healthy Chinese Subjects: A Phase I, Open-Label Study.

Clin Pharmacol Drug Dev 2020 Jun 21. Epub 2020 Jun 21.

Clinical Pharmacology Centre, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

In patients with coronary heart disease undergoing primary prevention, hypertriglyceridemia is a residual risk for cardiovascular events. Omega-3 carboxylic acid (OM3-CA), a mixture of the free fatty acid forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may be beneficial in reducing triglyceride levels. As part of the clinical development program of OM3-CA in China, this phase I study evaluated the pharmacokinetics, safety, and tolerability profile of OM3-CA in healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.800DOI Listing

Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice.

Food Sci Nutr 2020 Jun 18;8(6):2588-2597. Epub 2020 Mar 18.

Shandong Provincial Hospital and School of Medicine Shandong University Jinan China.

Oxidative stress and inflammation contribute to hypertriglyceridemia-induced nonalcoholic fatty liver disease (NAFLD). Cholesterol-enriched diets increase the risk of NAFLD. Murr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/fsn3.1445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300084PMC

Development and validation of a tool for predicting type 2 diabetes in Mexican women of reproductive age.

Endocrinol Diabetes Nutr 2020 Jun 18. Epub 2020 Jun 18.

Departamento de Endocrinología y Metabolismo del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Unidad de Posgrados. Universidad Nacional Autónoma de México, Mexico. Electronic address:

Introduction: Diabetes is a worldwide problem with a greater impact in developing countries, where many people are unaware of their risk. In Mexico, women show the greatest risk for T2D. Current risk scores have been developed and validated in predominantly older European cohorts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.endinu.2020.02.006DOI Listing

ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death.

Metabolism 2020 Jun 17;109:154296. Epub 2020 Jun 17.

Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China. Electronic address:

Rationale: ApoC2 is an important activator for lipoprotein lipase-mediated hydrolysis of triglyceride-rich plasma lipoproteins. ApoC2-deficient patients display severe hypertriglyceridemia (sHTG) and recurrent acute pancreatitis. However, due to embryonic lethality in ApoC2 deleted mouse extensive understanding of ApoC2 function is limited in mammalian species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2020.154296DOI Listing

Non-HDL Cholesterol or apoB: Which to Prefer as a Target for the Prevention of Atherosclerotic Cardiovascular Disease?

Curr Cardiol Rep 2020 Jun 19;22(8):67. Epub 2020 Jun 19.

Mike and Valeria Rosenbloom Centre for Cardiovascular Prevention, Division of Cardiology, Royal Victoria Hospital-McGill University Health Centre, Montreal, Quebec, Canada.

Purpose Of Review: Guidelines propose using non-HDL cholesterol or apolipoprotein (apo) B as a secondary treatment target to reduce residual cardiovascular risk of LDL-targeted therapies. This review summarizes the strengths, weaknesses, opportunities, and threats (SWOT) of using apoB compared with non-HDL cholesterol.

Recent Findings: Non-HDL cholesterol, calculated as total-HDL cholesterol, includes the assessment of remnant lipoprotein cholesterol, an additional risk factor independent of LDL cholesterol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11886-020-01323-zDOI Listing

Gene-environment interaction between APOA5 c.553G>T and pregnancy in hypertriglyceridemia-induced acute pancreatitis.

J Clin Lipidol 2020 May 21. Epub 2020 May 21.

Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The etiology of hypertriglyceridemia (HTG) and, consequently, HTG-induced acute pancreatitis (HTG-AP), is complex.

Objective: Herein, we explore a possible gene-environment interaction between APOA5 c.553G>T (p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacl.2020.05.003DOI Listing

Circulating IGFBP-2 levels reveal atherogenic metabolic risk in schizophrenic patients using atypical antipsychotics.

World J Biol Psychiatry 2020 Jun 17:1-8. Epub 2020 Jun 17.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, Canada.

Second generation antipsychotics (SGAs) induce weight gain and dyslipidemia, albeit with important intervariability. Insulin-like growth factor binding protein (IGFBP)-2 is proposed as a circulating biomarker negatively associated with waist circumference and hypertriglyceridemia. Thus, we tested whether metabolic alterations developed upon the use of SGAs are associated with plasma IGFBP-2 levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15622975.2020.1770858DOI Listing

Vitamin D supplementation after the menopause.

Ther Adv Endocrinol Metab 2020 5;11:2042018820931291. Epub 2020 Jun 5.

Department of Internal Medicine, Medical University of Graz, Graz, Austria.

The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions associated with vitamin D deficiency and interventions to manage them. Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2042018820931291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278294PMC

Retrospective Analysis of Cardiovascular Disease Risk Parameters in Participants of a Preventive Health and Wellness Program.

Integr Med (Encinitas) 2019 Jun;18(3):78-95

Scripps Green Hospital, University of California San Diego, located in La Jolla, Calfornia.

Lifestyle, dietary, and nutritional choices are important influencing parameters of cardiovascular disease (CVD) risk, the number one cause of morbidity and mortality globally. Our aims were to i) characterize CVD risk parameters using data from 7939 participants enrolled in a preventive health and wellness program between March 2010 and January 2017; and ii) evaluate intervention effects in 3,020 participants who returned for follow-up. Blood measurements (nutrient markers), CVD risk parameters (abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein (HDL), insulin resistance, and inflammation), glycemic status (HbA1c), and insulin resistance (HOMA-IR) were assessed. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217396PMC

Macrophage activation syndrome as a complication of dermatomyositis: A case report.

World J Clin Cases 2020 Jun;8(11):2339-2344

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Macrophage activation syndrome (MAS) can be a fatal complication of rheumatic disorders, which occurs most commonly in patients with systemic juvenile idiopathic arthritis or systemic lupus erythematosus. It has rarely been reported in patients with dermatomyositis. Here, we describe a fatal case of MAS that developed in an adult patient with dermatomyositis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v8.i11.2339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281037PMC

2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats.

Eur J Pharmacol 2020 Jun 13;882:173278. Epub 2020 Jun 13.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

Metabolic syndrome (MetS) is a common disorder that is associated with hypertension and poses a significant cardiovascular risk. Deactivation of extra-neuronal norepinephrine is mediated by catechol-O-methyltransferase (COMT). Endogenous 2-methoxyestradiol (2ME) is a product of COMT activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2020.173278DOI Listing

Loss of association between HbA1c and vascular disease in older adults with type 1 diabetes.

PLoS One 2020 15;15(6):e0234319. Epub 2020 Jun 15.

Imperial College Healthcare NHS Trust, London, United Kingdom.

Aims: Robust evidence supports intensive glucose control in those with recently diagnosed type 1 diabetes to reduce the risk of developing micro- and macrovascular complications. Data to support longitudinal glycaemic targets is lacking. We aimed to explore if longer duration of diabetes and greater age might reduce the impact of glycaemia on the risk of vascular complications. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234319PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295188PMC

HIV, Antiretroviral Therapy and Metabolic Alterations: A Review.

Cureus 2020 May 11;12(5):e8059. Epub 2020 May 11.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

The introduction of antiretroviral therapy (ART) has caused some metabolic problems to people who suffer from HIV. ART probably is not the sole reason for these metabolic disorders. Most likely, HIV itself affects the metabolism as well. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286589PMC

Prevalence of hypertriglyceridemia in adults and related cardiometabolic factors. SIMETAP-HTG study.

Clin Investig Arterioscler 2020 Jun 10. Epub 2020 Jun 10.

Centro de Salud Comillas, Madrid, España.

Aim: To determine in the adult population the crude and the sex- and age-adjusted prevalence rates of hypertriglyceridaemia (HTG) and to assess its association with cardiovascular risk factors, chronic kidney disease, cardiovascular and cardiometabolic diseases.

Methods: Cross-sectional observational study conducted in Primary Care, with 6,588 adult study subjects, randomly selected on base-population. Patients had HTG if the triglyceride level was≥150mg/dL (≥1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arteri.2020.04.001DOI Listing