50,264 results match your criteria Hyperthyroidism Thyroid Storm & Graves Disease

Henoch-Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis.

Case Rep Endocrinol 2021 22;2021:6669653. Epub 2021 May 22.

Pathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Graves' disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch-Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch-Schönlein purpura (IgA vasculitis) as a side effect. Read More

View Article and Full-Text PDF

Hyperthyroidism Prevalence in China After Universal Salt Iodization.

Front Endocrinol (Lausanne) 2021 28;12:651534. Epub 2021 May 28.

Zhejiang Center for Disease Control and Prevention (Zhejiang CDC), Hangzhou, China.

Background: Universal salt iodization (USI) was implemented in mainland China in 1996. The prevalence of hyperthyroidism and its risk factors now require examination.

Methods: Data were acquired from a nationwide Thyroid, Iodine, and Diabetes Epidemiological survey (TIDE 2015-2017) of 78,470 subjects from 31 provinces. Read More

View Article and Full-Text PDF

Graves'-induced prothrombotic state and the risk of early-onset myocardial infarction.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Imperial College Healthcare NHS Trust, London, UK

Hyperthyroidism represents a state of hypercoagulability and hypofibrinolysis, which predisposes an individual to the increased risk of thromboembolism. We present a case of a 25-year-old patient presenting with an acute myocardial infarction secondary to plaque rupture with thrombotic occlusion of proximal left anterior descending artery, in a patient known to have Graves' disease. She had a sudden ventricular fibrillation arrest and a precordial thump given and cardiopulmonary resuscitation started. Read More

View Article and Full-Text PDF

Hyperthyroidism in severe mitral regurgitation post mechanical mitral valve replacement: the effect on warfarin anticoagulation.

Cardiovasc Endocrinol Metab 2021 Jun 17;10(2):146-148. Epub 2020 Sep 17.

Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia-National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

A 24-year-old male patient came to the emergency room with melena, gum bleeding and nosebleeds. This patient has a history of mechanical prosthetic mitral valve replacement for severe mitral regurgitation (MR) and consumed warfarin irregularly, but did not come back for regular check-up. Investigations showed greatly increased thyroid function and international normalised ratio (INR) was 15. Read More

View Article and Full-Text PDF

Analysis of the physiological and pathological factors of hospitalized patients taking warfarin and the correlation between drug interactions and warfarin efficacy.

Ann Palliat Med 2021 May;10(5):5400-5406

Department of Pharmacy, Shenzhen Hospital of Southern Medical University, Shenzhen, China.

Background: To study the various factors affecting the anticoagulant effect of warfarin, and to promote the rational use of warfarin.

Methods: We collected the medical records of 125 hospitalized patients who used warfarin from January 2018 to December 2019. Statistical analysis was performed on characteristics such as gender, age, treatment, diabetes, hyperlipidemia, hyperthyroidism, hypothyroidism, hepatitis, renal insufficiency, and nephritis; along with other pathological factors, such as aspirin, clopidogrel, spironolactone, amiodarone, amlodipine, trimetazidine, bisoprolol, isosorbide, atorvastatin, furosemide, digoxin, metoprolol, acarbose, levamlodipine, enoxaparin, moxifloxacin, levofloxacin, other drug interactions, and comorbidities. Read More

View Article and Full-Text PDF

SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves' disease.

Endocrine 2021 Jun 9. Epub 2021 Jun 9.

Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.

Coronavirus disease 2019 (COVID-19) advances to affect every part of the globe and remains a challenge to the human race. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) was shown to affect many organs and organ systems including the thyroid gland as these parts highly express angiotensin-converting enzyme 2 (ACE2) protein, which functions as a receptor for initially entering the virus into the cells. Furthermore, some categories of the population including older people and persons with comorbidities are prone to be more vulnerable to COVID-19 and its complications. Read More

View Article and Full-Text PDF

Determining Anterior Fontanel Size and Associated Factors Among Term Neonates on the First Day of Life Born at Jimma University Medical Center (JUMC), Southwest Ethiopia: A Linear Regression Model.

Pediatric Health Med Ther 2021 1;12:269-278. Epub 2021 Jun 1.

School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Background: Knowledge of the normal variation in AF size may be helpful to cue early diagnosis of congenital hypothyroidism, hyperthyroidism, cardiac disease, meningitis, degree of dehydration or provide a clue to disorders of neural and skeletal development. However, the data is scarce. Therefore, this study was aimed to determine AF size and associated factors among term neonates on the first day of life born in Jimma University Medical Center (JUMC), Southwest Ethiopia. Read More

View Article and Full-Text PDF

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study.

Biomed Phys Eng Express 2021 Jun 16;7(4). Epub 2021 Jun 16.

Institute of Biomedical Engineering, Bogazici University, Kandilli Kampus, Cengelkoy, 34684 Istanbul, Turkey.

. SPECT-CT is a standard procedure conducted before minimally invasive surgery for the treatment of primary hyperthyroidism. In order to improve image quality, it is important to know how defect detectability is influenced by acquisition and processing parameters. Read More

View Article and Full-Text PDF

A randomised, controlled trial to determine the effect of levothyroxine on Standardbred racehorses.

Equine Vet J 2021 Jun 8. Epub 2021 Jun 8.

Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, 47907, USA.

Background: The use of thyroid supplement is pervasive in athletic horses although its effects on measures of performance are not known.

Objectives: One purpose of this study was to determine whether supra-physiologic doses of levothyroxine affect the velocities at which blood lactate was greater than 4 mmol/L (V ) and heart rate was over 150 (V ) and 200 (V ) beats per minute respectively. Additionally, a survey of post-race blood samples was also conducted to determine whether high thyroxine concentrations were common in racehorses. Read More

View Article and Full-Text PDF

Received dose variability after administration of I-131 for treatment of hyperthyroidism in cats.

J Vet Intern Med 2021 Jun 6. Epub 2021 Jun 6.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Background: Injectable radioactive iodine (I-131) frequently is used to treat hyperthyroidism in cats. In human medicine, residual activity after injection of radionuclides has been reported, and the actual quantity administered is recorded after administration.

Objective: Our aim was to evaluate actual administered dose variability after administration of preprepared I-131 single unit doses for the treatment of hyperthyroidism in cats. Read More

View Article and Full-Text PDF

Unusual Endocrinopathies in 18q Deletion Syndrome: Pseudoparathyroidism and Hyper-/Hypo-Thyroidism.

AACE Clin Case Rep 2021 May-Jun;7(3):192-194. Epub 2020 Dec 24.

Department of Pediatric Endocrinology, University of South Alabama, Mobile, Alabama.

Objective: To describe new and unusual endocrinopathies in children with de novo 18q deletion (18q-) syndrome.

Methods: We describe 2 patients who have atypical thyroid conditions and 1 who also developed symptomatic hypocalcemia.

Results: The first patient developed hyperthyroidism at the age of 3 years, with a free thyroxine level of 3. Read More

View Article and Full-Text PDF
December 2020

Post-COVID-19 Fatigue: A Case of Infectious Hypothyroidism.

Cureus 2021 May 3;13(5):e14815. Epub 2021 May 3.

Internal Medicine/Nephrology, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Elmhurst, USA.

Since the beginning of the coronavirus disease 2019 (COVID-19) global pandemic, an array of different clinical sequela and comorbid conditions have been discovered to be associated with COVID-19 infection. Of these sequela, subacute thyroiditis (SAT) causing hyperthyroidism has been prominent, more commonly affecting women. However, our case details a 49-year-old male patient with no history of thyroid disease showing signs and symptoms of hypothyroidism for six months after recovery from COVID-19 infection. Read More

View Article and Full-Text PDF

US-guided percutaneous microwave ablation for hyperthyroidism and immediate treatment response evaluation with contrast-enhanced ultrasound.

Clin Hemorheol Microcirc 2021 Jun 3. Epub 2021 Jun 3.

Center of Minimally Invasive Treatment for Tumor, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai, China.

Hyperthyroidism is a common disease mainly manifested by hyperexcitability of multiple systems and hypermetabolism. Currently, antithyroid drugs (ATDs), radioiodine therapy (RIT), and surgery are mainly used in the clinical treatment for primary hyperthyroidism. We reported a case of a 28-year-old female who received a novel treatment for primary hyperthyroidism. Read More

View Article and Full-Text PDF

Serum Raman spectroscopy combined with Deep Neural Network for analysis and rapid screening of hyperthyroidism and hypothyroidism.

Photodiagnosis Photodyn Ther 2021 Jun 6;35:102382. Epub 2021 Jun 6.

College of Information Science and Engineering, Xinjiang University, Urumqi 830046, China; College of Software, Xinjiang University, Urumqi 830046, Xinjiang, China; Key Laboratory of signal detection and processing, Xinjiang University, Urumqi 830046, Xinjiang, China.

Hyperthyroidism and hypothyroidism may cause a series of clinical complications have a high incidence, and early diagnosis is beneficial to treatment. Based on Raman spectroscopy and deep learning algorithms, we propose a rapid screening method to distinguish serum samples of hyperthyroidism patients, hypothyroidism patients and control subjects. We collected 99 serum samples, including 38 cases from hyperthyroidism patients, 32 cases from hypothyroidism patients and 29 cases from control subjects. Read More

View Article and Full-Text PDF

Nonspecific orbital inflammation and thyroid eye disease, a rare comorbidity: report of two cases and review of literature.

BMC Ophthalmol 2021 Jun 5;21(1):251. Epub 2021 Jun 5.

Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: To present the very rare comorbidity of developing non-specific orbital inflammation (NSOI) in two patients with histories of definite thyroid eye disease (TED).

Case Presentation: Both patients complained of new-onset progressive proptosis although their thyroid disease was controlled and computed tomography scan revealed an intraorbital inflammatory mass. The pathological assessment indicated that both patients had developed fibrosing NSOI. Read More

View Article and Full-Text PDF

Potential pitfalls when interpreting plasma BNP levels in heart failure practice.

J Cardiol 2021 Jun 1. Epub 2021 Jun 1.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

B-type (or brain) natriuretic peptide (BNP) is synthesized in cardiac myocytes and released constitutively into the circulation. Pressure/volume overload, neurohumoral factors, cytokines, and ischemia enhance BNP gene expression, and then precursor proBNP is produced. It has been thought that proBNP is cleaved into active BNP molecule and inactive marker molecule NT-proBNP intracellularly by processing enzyme furin, and they are released into the circulation. Read More

View Article and Full-Text PDF

Urticaria as a manifestation of hyperthyroidism.

Clin Case Rep 2021 May 5;9(5):e03620. Epub 2021 May 5.

Tameside and Glossop Integrated Care NHS Foundation Trust Ashton-Under-Lyne UK.

In clinically euthyroid patients presenting with urticaria, a trial period of withholding antithyroid medications can be exercised. In clinically hyperthyroid patients, antithyroid medications may be stopped with close observation of response. Read More

View Article and Full-Text PDF

A Rare Clinical Manifestation of Graves' Disease: Evans Syndrome and a Review of the Literature.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):518-521

University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital - Endocrinology and Metabolism - Ankara, Turkey.

Evans syndrome is a rare combination of autoimmune hemolytic anemia and immune thrombocytopenia. Evans syndrome in cases of Graves' disease is extremely rare. The coexistence of these autoimmune diseases suggests that they may share a common pathogenic pathway. Read More

View Article and Full-Text PDF

The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones in rats with hypothyroidism and hyperthyroidism.

J Food Biochem 2021 Jun 3:e13801. Epub 2021 Jun 3.

Department of Physiology, Faculty of Milas Veterinary Medicine, University of Mugla Sıtkı Kocman, Mugla, Turkey.

In our study, the effect of essential oil obtained from Nigella sativa L. (NSE) on thyroid hormones and antioxidant balance in hypothyroidism (HT) and hyperthyroidism (HP) models induced by propylthiouracil(PTU) and L-thyroxine(LT ), respectively, in rats were investigated for 4 weeks. NSE was administered by gastric gavage at a dose of 200 mg/kg body weight. Read More

View Article and Full-Text PDF

A Diagnosis of Maternal Hyperthyroidism.

Neoreviews 2021 Jun;22(6):e409-e414

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL.

View Article and Full-Text PDF

Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals.

Nutrients 2021 May 28;13(6). Epub 2021 May 28.

Neurological Health Foundation, Dallas, TX 75230, USA.

The levels of many essential minerals decrease during pregnancy if un-supplemented, including calcium, iron, magnesium, selenium, zinc, and possibly chromium and iodine. Sub-optimal intake of minerals from preconception through pregnancy increases the risk of many pregnancy complications and infant health problems. In the U. Read More

View Article and Full-Text PDF

Involvement of Thyroid Hormones in Brain Development and Cancer.

Cancers (Basel) 2021 May 30;13(11). Epub 2021 May 30.

Department of Biomedicine, Neurosciences and Advanced Diagnostics (Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata) (Bi.N.D.), University of Palermo, 90127 Palermo, Italy.

The development and maturation of the mammalian brain are regulated by thyroid hormones (THs). Both hypothyroidism and hyperthyroidism cause serious anomalies in the organization and function of the nervous system. Most importantly, brain development is sensitive to TH supply well before the onset of the fetal thyroid function, and thus depends on the trans-placental transfer of maternal THs during pregnancy. Read More

View Article and Full-Text PDF

Efficacy and Safety of Durvalumab Combined with Daratumumab in Daratumumab-Refractory Multiple Myeloma Patients.

Cancers (Basel) 2021 May 18;13(10). Epub 2021 May 18.

Cancer Center Amsterdam, Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.

Daratumumab is active both as a single agent and in combination with other agents in multiple myeloma (MM) patients. However, the majority of patients will develop daratumumab-refractory disease, which carries a poor prognosis. Since daratumumab also has immunomodulatory effects, addition of the PD-L1 blocking antibody durvalumab at the time of progression may reverse daratumumab-resistance. Read More

View Article and Full-Text PDF

The Role of Thyroid Hormone in Neuronal Protection.

Compr Physiol 2021 Jun 1;11(3):1-21. Epub 2021 Jun 1.

Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

Thyroid hormone is essential for brain development and brain function in the adult. During development, thyroid hormone acts in a spatial and temporal-specific manner to regulate the expression of genes essential for normal neural cell differentiation, migration, and myelination. In the adult brain, thyroid hormone is important for maintaining normal brain function. Read More

View Article and Full-Text PDF

[Lithium as an adjuvant to I therapy for hyperthyroidism complicated by severe jaundice in 4 cases].

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):561-563

Department of Nuclear Medicine, Fifth Medical Center of General Hospital of PLA, Beijing 100071,China.

View Article and Full-Text PDF

Incidence of Dysphonia and Dysphagia Exceeds Recurrent Laryngeal Nerve Injury During Thyroid Surgery.

J Voice 2021 May 27. Epub 2021 May 27.

Loma Linda University Health, Department of Otolaryngology, Loma Linda, California.

Objectives: To determine the prevalence of separate and combined voice and swallowing impairments before and after total thyroidectomy and to delineate risk factors for these symptoms.

Methods: Retrospective review of 592 consecutive patients who underwent total thyroidectomy from July 2003 to August 2015.

Results: Combined voice and swallowing problems occurred preoperatively in 4. Read More

View Article and Full-Text PDF

Five-year follow-up and clinical outcome in euthyroid patients with thyroid nodules.

Radiol Oncol 2021 May 31. Epub 2021 May 31.

Department of Nuclear Medicine, University Medical Centre Ljubljana, LjubljanaSlovenia.

Background: Thyroid nodule diagnosis has become increasingly frequent. Defining optimum surveillance intervals for patients with unsuspicious thyroid nodules remains a challenge. This was a single centre cohort study in which patients diagnosed with unsuspicious thyroid nodules in whom no treatment was indicated were invited for re-evaluation 5 years after the diagnosis. Read More

View Article and Full-Text PDF

Adolescent Thyroid disorders and Risk for Type 2 Diabetes in Young Adulthood.

J Clin Endocrinol Metab 2021 May 29. Epub 2021 May 29.

Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.

Context: Thyroid hormones play a key role in systemic metabolism, yet the relationship between thyroid dysfunction and risk for type 2 diabetes is unclear.

Objective: To assess type 2 diabetes risk in adulthood among adolescents with thyroid disorders.

Design And Setting: A nationwide, population-based study of Israeli adolescents who were examined before military recruitment during 1988-2007, and were followed until December 31, 2016. Read More

View Article and Full-Text PDF

Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study.

Endocrine 2021 May 28. Epub 2021 May 28.

Endocrinology, Diabetology and Medical Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089, Milan, Italy.

Purpose: To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis.

Methods: This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43-85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up for a median period of 90 days (range: 30-120) after hospital discharge. At follow-up, patients were evaluated for serum thyrotropin (TSH), free-thyroxine (FT4), free-triiodiothyronine (FT3), TSH receptor antibodies (TRAb), thyroglobulin antibodies (TgAb), thyroperoxidase antibodies (TPOAb) and ultrasonographic thyroid structure. Read More

View Article and Full-Text PDF

Systematic review and meta-analysis for the value of thyroid disorder screening in men with ejaculatory dysfunction.

Int J Clin Pract 2021 May 28:e14419. Epub 2021 May 28.

School of Medicine, Department of Urology, Dokuz Eylül University, Izmir, Turkey.

Objective: To demonstrate evidence from available clinical studies to clarify the scientific points that have been achieved in relation to thyroid disorders and ejaculatory dysfunction (EjD).

Data Sources: Clinical trial articles published in English on Medline.

Eligibility Criteria: Clinical studies that investigated the association of thyroid disorders with the ejaculatory function of subjects and the trials evaluating the effect of thyroid dysfunction treatment on the ejaculatory function of the subjects were eligible. Read More

View Article and Full-Text PDF