51,789 results match your criteria Hyperthyroidism Thyroid Storm & Graves Disease


Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management.

Authors:
Philippe Caron

Endocrine 2022 Jun 28. Epub 2022 Jun 28.

Department of Endocrinology and Metabolic Diseases, Cardiovascular and Metabolic Unit, CHU-Larrey, Toulouse, France.

Since the Covid-19 pandemic emerged in 2019, several adenoviral-vectored, mRNA-based and inactivated whole-virus vaccines have been developed. A massive vaccination campaign has been undertaken around the world, and an increasing number of SARS-CoV-2 vaccine-induced thyroid diseases have been described in the literature. Subacute thyroiditis has been reported in 52 patients, mean age 45. Read More

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Case report: hypoglycemia secondary to methimazole-induced insulin autoimmune syndrome in young Taiwanese woman with Graves' disease.

Medicine (Baltimore) 2022 Jun 24;101(25):e29337. Epub 2022 Jun 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Rationale: Hypoglycemia is an emergent condition with many causes, including underlying diabetes mellitus either with the use of insulin or oral anti-diabetic medications for glucose control, and organ (heart, hepatic, or renal) failure. Insulin autoimmune syndrome (IAS) can also cause hypoglycemia, however it is relatively difficult to diagnose as it is rare clinically. Although uncommon, IAS can be life threatening in patients with persistent hypoglycemia. Read More

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["Block and replace" of sodium levothyroxine therapy].

Recenti Prog Med 2022 Jun;113(6):11e-14e

We present the case of a 65 years old patient with Graves disease associated with hyperthyroidism and a medical history of bipolar disorder treated with lithium. Hyperthyroidism was initially treated with high-dose methimazole monotherapy and later the patient developed overt hypothyroidism (clinical and biochemical), but without remission of the underlying autoimmune disease. A "block and replace" therapeutic regimen was then started with reduced methimazole doses in combination with levothyroxine, which resulted in a short time in normalization of the hormonal profile and significant improvement of the clinical picture. Read More

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[Thyroxine replacement therapy in patients with thyroid cancer and thyroid hormone resistance syndrome].

Authors:
Andrea Corsello

Recenti Prog Med 2022 Jun;113(6):7e-10e

Resistance to thyroid hormone (RTH) is a genetic syndrome defined by an impaired sensitivity to thyroid hormones. It is characterized by discrepancies between the blood levels of thyroid hormones (FT3, FT4) and TSH, and by the coexistence of hypothyroidism and hyperthyroidism symptoms. Here we describe the case of a patient affected with thyroid cancer and RTH in whom it was difficult to obtain a good control of TSH after total thyroidectomy despite high doses of thyroxine replacement therapy. Read More

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'The Mercury Challenge': feline systolic blood pressure in primary care practice - a European survey.

J Feline Med Surg 2022 Jun 27:1098612X221105844. Epub 2022 Jun 27.

Companion Animal Franchise, Ceva Santé Animale, Libourne, France.

Objectives: The aim of this study was to collect data from a substantial number of older cats having their systolic blood pressure (SBP) measured in a variety of clinical practices, to describe the findings and assess variables that affected the duration of assessment and the values obtained.

Methods: An international (European-based) multicentre convenience sample survey of cats ⩾7 years of age attending veterinary clinics and having SBP measured as part of their clinical assessment. Information gathered included details of the cat, concomitant disease(s) or therapies, SBP results, device used, time taken to assess SBP and the demeanor of the cat. Read More

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Cardiovascular Manifestations in Hyperthyroidism: A Cross-Sectional Study in a Tertiary Care Hospital in South India.

Cureus 2022 May 23;14(5):e25232. Epub 2022 May 23.

Community Medicine, Noida International Institute of Medical Sciences, Noida, IND.

Background The involvement of the heart in hyperthyroidism patients has a considerable prognostic value and causes significant morbidity and mortality. However, very little research, particularly among the Indian population, has addressed the most critical cardiovascular symptoms of hyperthyroidism, so this study aimed to assess the cardiovascular manifestations of hyperthyroidism. Method The current cross-sectional investigation involved 140 newly diagnosed and untreated confirmed cases of hyperthyroidism of any etiology for nine months. Read More

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Cerebrovascular intervention therapy worked positively in one patient with severe cerebral venous sinus thrombosis due to hyperthyroidism: a case report and review of the literature.

J Med Case Rep 2022 Jun 26;16(1):250. Epub 2022 Jun 26.

Department of Neurology, Shanghai Xuhui District Central Hospital, 966 Middle Huaihai Road, Xuhui District, Shanghai, China.

Background: With further understanding of cerebral venous sinus thrombosis, hyperthyroidism has gradually been revealed as a rare predisposing factor for cerebral venous sinus thrombosis, which may present as more compact clots and resistance to fibrinolysis, also known as a predictor of worse outcomes. For patients with severe cerebral venous sinus thrombosis, proper treatment method should be initiated as soon as possible since they may deteriorate rapidly.

Case Presentation: In this case report, we present a 32-year-old Mongoloid woman admitted with progressive headache, impaired consciousness, and right limb weakness, diagnosed with cerebral venous sinus thrombosis caused by hyperthyroidism. Read More

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Radioiodine treatment of pediatric Graves disease: a multicenter review.

Pediatr Radiol 2022 Jun 25. Epub 2022 Jun 25.

Department of Radiology, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, USA.

Background: There is no standardized approach to iodine-131 (I-131) therapy of hyperthyroidism in pediatric Graves disease. This prevents systematic study of outcomes.

Objective: To characterize current radioiodine dosing and define therapeutic outcomes at multiple institutions that use ultrasound to measure thyroid size to guide I-131 ablation of Graves disease. Read More

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Radioiodine treatment of hyperthyroidism in cats: results of 165 cats treated by an individualised dosing algorithm in Spain.

J Feline Med Surg 2022 Jun 24:1098612X221104743. Epub 2022 Jun 24.

Animal Endocrine Clinic, New York, NY, USA.

Objectives: Although radioiodine (I) is the treatment of choice for feline hyperthyroidism, I-dosing protocols commonly induce iatrogenic hypothyroidism and expose azotaemia. A recently reported patient-specific I dosing algorithm minimised the risk of I-induced hypothyroidism and azotaemia, while maintaining high cure rates. The aim of the study was to report results of I treatment in a European population of hyperthyroid cats using this patient-specific dosing algorithm. Read More

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Differential Diagnosis of Thyrotoxicosis by Machine Learning Models with Laboratory Findings.

Diagnostics (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea.

Differential diagnosis of thyrotoxicosis is essential because therapeutic approaches differ based on disease etiology. We aimed to perform differential diagnosis of thyrotoxicosis using machine learning algorithms with initial laboratory findings. This is a retrospective study through medical records. Read More

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TSH-receptor antibodies in early pregnancy.

J Clin Endocrinol Metab 2022 Jun 23. Epub 2022 Jun 23.

Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.

Context: TSH-receptor antibodies (TRAb) are important when distinguishing between Graves' and gestational hyperthyroidism, but sparse evidence exists on the recommended cut-off in pregnancy.

Objective: To establish a method- and pregnancy-specific cut-off for TRAb, to describe the frequency of TRAb positivity in early pregnancy, and to follow up the women in the years after pregnancy.

Design: Cohort study. Read More

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COVID-19 and thyroid function: A bi-directional two-sample Mendelian randomization study.

Thyroid 2022 Jun 23. Epub 2022 Jun 23.

The University of Hong Kong, 25809, Department of Pharmacology and Pharmacy, Hong Kong, Hong Kong;

Background: Thyroid dysfunction has been observed among some patients with COVID-19. It is unclear whether SARS-CoV-2 infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits [including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease (AITD)] and three continuous traits of thyroid hormones [including thyroid-stimulating hormone (TSH) and free thyroxine (FT4) within reference range, and TSH in full range]. Read More

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Paroxysmal supine hypoxaemia with hyperthyroidism and atrial fibrillation: a case report of a diagnostic challenge.

Eur Heart J Case Rep 2022 Jun 24;6(6):ytac214. Epub 2022 May 24.

Mayo Clinic Rochester, Department of Cardiovascular Medicine, USA.

Background: A patent foramen ovale (PFO) is a persistent embryonic defect in the interatrial septum. Platypnoea-orthodeoxia syndrome is characterized by positional hypoxaemia that is most commonly due to right-to-left shunting through a PFO. Dynamic right-to-left shunting through a PFO can also exacerbate positional hypoxaemia without platypnea-orthodeoxia syndrome. Read More

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Membranous Nephropathy Secondary to Graves' Disease: A Case Report.

Front Immunol 2022 6;13:824124. Epub 2022 Jun 6.

Pathology Division, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Membranous nephropathy (MN) is a form of kidney disease that is idiopathic in 70%-80% of cases. Glomerular involvement in autoimmune thyroiditis can occur in 10%-30% of patients, and MN manifests in association with Hashimoto thyroiditis in up to 20% of the cases with glomerular involvement. Reports of MN associated with Graves' disease (GD) are extremely rare in the current literature. Read More

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Update on subclinical thyroid dysfunction.

Authors:
Koshi Hashimoto

Endocr J 2022 Jun 22. Epub 2022 Jun 22.

Department of Diabetes, Endocrinology, and Hematology, Dokkyo Medical University Saitama Medical Center, Saitama 343-8555, Japan.

Subclinical thyroid dysfunction is defined by serum thyroid-stimulating hormone (TSH) levels either greater or less than the reference range with normal thyroxine (T4) concentrations, and consists of subclinical hypothyroidism (SCH) and subclinical hyperthyroidism (SCHyper). For the proper diagnosis of SCH, it is most important to be able to correctly evaluate the serum TSH levels, which have numerous unique characteristics. We also need to be versed in TSH harmonization, which was recently launched world-wide. Read More

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Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease.

BMJ Open 2022 Jun 21;12(6):e050337. Epub 2022 Jun 21.

Department of Ophthalmology, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)

Objectives: The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.

Design: This was a multicentre, prospective, observational study. Read More

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Surgical management of Graves' disease: historical context and single institution experience.

N Z Med J 2022 Feb 4;135(1549):43-49. Epub 2022 Feb 4.

FRACS, Breast, Endocrine, Laparoscopic and Melanoma Surgeon, Department of General Surgery, Waitematā DHB, Auckland.

Aim: To describe indications and outcomes of total thyroidectomy for Graves' disease in a large New Zealand endocrine surgery unit, and to compare these results to international studies.

Methods: We analysed a prospectively collected database to describe the indications and outcomes of surgery for Graves' disease between December 2001 and January 2021.

Results: Among 64 patients who underwent total thyroidectomy at our tertiary centre for Graves' hyperthyroidism, Graves' ophthalmopathy and patient preference/aversion to radioactive iodine were the most common indications for surgery. Read More

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February 2022

PD-1 Inhibitor-Induced Thyrotoxicosis Associated with Coronary Artery Spasm and Ventricular Tachycardia.

Cardiovasc Toxicol 2022 Jun 21. Epub 2022 Jun 21.

Department of Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.

Programmed cell death protein 1 (PD-1) inhibitors open a new era of cancer immunotherapy, but they are associated with immune-related adverse events (irAEs) involving multiple endocrine organs of which thyroid dysfunction is the most common An uncommon condition of coronary artery spasm and ventricular tachycardia associated with thyrotoxicosis, induced by a PD-1 inhibitor, is discussed in this case. A 60-year-old male patient with a 1-week history of chest tightness and palpitation at rest was referred to us in July 2021. No obvious abnormalities were noted on physical examination and electrocardiography. Read More

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A Case Report of Concurrent Graves' Disease and Subacute Thyroiditis Following SARS-CoV-2 Vaccination: An Autoimmune/Inflammatory Syndrome (ASIA).

Endocr Metab Immune Disord Drug Targets 2022 Jun 21. Epub 2022 Jun 21.

Department of Endocrinology and Metabolism, Faculty of Medicine, Başkent University, Ankara, Turkey.

Background: The response against adjuvants in vaccines is presented as autoimmune/inflammatory syndrome (ASIA). In this case report, we presented both SAT and Graves' disease in a patient as ASIA following the BNT162b2 mRNA COVID-19 vaccination.

Case Presentation: A 31-year-old woman was admitted to the endocrinology outpatient clinic with the complaint of neck pain following the second dose of the BNT162B2 SARS-CoV-2 (Pfizer/BioNTech) vaccine. Read More

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Hyperthyroidism due to thyrotropin receptor antibody stimulation of metastatic thyroid carcinoma during lenvatinib treatment: a case report.

Ann Palliat Med 2022 Jun 20. Epub 2022 Jun 20.

Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan.

Background: Hyperthyroidism after total thyroidectomy is extremely rare. No studies have investigated hyperthyroidism during multiple kinase inhibitor treatment for advanced thyroid carcinoma.

Case Description: A 57-year-old man with a history of radioactive iodine refracted thyroid follicular carcinoma presented to our hospital with back pain. Read More

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A unique presentation of Graves' disease in a pregnant woman with severe hypothyroidism.

Gynecol Endocrinol 2022 Jun 20:1-5. Epub 2022 Jun 20.

Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy.

Background: Graves' disease occurrence during pregnancy is not a frequent event, showing an incidence of 0.2-0.4% in unselected pregnant women. Read More

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The Association Between Subclinical Thyroid Dysfunction and Recurrence of Atrial Fibrillation After Catheter Ablation.

Front Cardiovasc Med 2022 3;9:902411. Epub 2022 Jun 3.

Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: The aim of this study was to evaluate the association between subclinical thyroid dysfunction and the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA).

Methods: We examined the association between subclinical thyroid dysfunction and the recurrence of AF at a large university-affiliated cardiac arrhythmia center in China. Data were collected from consecutive patients who underwent RFCA for AF, excluding those with a history of hypothyroidism, hyperthyroidism, or ongoing medical treatment for hypothyroidism or hyperthyroidism, biochemically defined overt thyroid disease, and long-term use of amiodarone before admission. Read More

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Mathematical Modeling of Free Thyroxine Concentrations During Methimazole Treatment for Graves' Disease: Development and Validation of a Computer-Aided Thyroid Treatment Method.

Front Endocrinol (Lausanne) 2022 31;13:841888. Epub 2022 May 31.

Institute of Automation and Control, Graz University of Technology, Graz, Austria.

Background: Methimazole (MMI) is the first-line treatment for patients with Graves' disease (GD). While there are empirical recommendations for initial MMI doses, there is no clear guidance for subsequent MMI dose titrations. We aimed to (a) develop a mathematical model capturing the dynamics of free thyroxine (FT4) during MMI treatment (b), validate this model by use of numerical simulation in comparison with real-life patient data (c), develop the software application Digital Thyroid (DigiThy) serving either as a practice tool for treating virtual patients or as a decision support system with dosing recommendations for MMI, and (d) validate this software framework by comparing the efficacy of its MMI dosing recommendations with that from clinical endocrinologists. Read More

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The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity.

Front Immunol 2022 2;13:864929. Epub 2022 Jun 2.

Center for Pharmacological Research, State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi, China.

The problem of aging is mainly the increase of age-related diseases, and elderly patients have longer hospitalization and worse prognosis. Poorer nutritional status and immunosenescence may be predisposing and severe factors. The mechanism of the high incidence of diseases and poor prognosis behind aging is complex. Read More

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A Global Regulatory Network for Dysregulated Gene Expression and Abnormal Metabolic Signaling in Immune Cells in the Microenvironment of Graves' Disease and Hashimoto's Thyroiditis.

Front Immunol 2022 26;13:879824. Epub 2022 May 26.

Department of Endocrinology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.

Background: Although the pathogenetic mechanisms of Hashimoto's thyroiditis (HT) and Graves' disease (GD) have been elucidated, the molecular mechanisms by which the abnormal immune function of cellular subpopulations trigger an autoimmune attack on thyroid tissue largely remains unexplained.

Methods: The study included 2 HT patients, 2 GD patients, and 1 control donor. The thyroid samples were extracted for single-cell RNA sequencing, whole transcriptome, full-length transcriptome (Oxford Nanopore Technologies), and metabolome sequencing. Read More

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Efficacy of Radioiodine Therapy in Patients With Primary Hyperthyroidism: An Institutional Review From Pakistan.

Cureus 2022 May 14;14(5):e24992. Epub 2022 May 14.

Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Background Radioactive iodine (RAI) is the treatment of choice for most patients with primary hyperthyroidism. The most common etiologies of hyperthyroidism are Graves' disease (GD), toxic adenoma (TA), and toxic multinodular goiter (TMNG). A single dose of RAI is usually sufficient to cure hyperthyroidism. Read More

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Graves' disease induced by Alemtuzumab in relapsing-remitting multiple sclerosis patients: an observational study in a reference center.

J Endocrinol Invest 2022 Jun 20. Epub 2022 Jun 20.

Endocrinology and Nutrition Department, University Hospital Virgen Macarena, Seville, Spain.

Objectives: Graves' disease induced by Alemtuzumab (GD-IA) is one of the most frequently observed adverse events in patients with multiple sclerosis (MS) treated with this drug. The aim of this study is the sequencing and description of these events, along with the identification of the risk factors leading to their development.

Materials And Methods: We conducted a retrospective observational study identifying patients with relapsing-remitting multiple sclerosis (RRMS) and GD-IA, studying their baseline clinical features and variables related to the natural history of the disease. Read More

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Thyroid Storm in an Adolescent Girl Precipitated by Empyema Thoracis.

Oman Med J 2022 May 31;37(3):e371. Epub 2022 May 31.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Thyroid storm is a rare, life-threatening condition in children. We report the case of a 16-year-old girl who presented with fever, cough, chest pain, and breathing difficulty. On the initial evaluation, a working diagnosis of left-sided pneumonia with empyema was made. Read More

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Empirical Method for Thyroid Disease Classification Using a Machine Learning Approach.

Biomed Res Int 2022 7;2022:9809932. Epub 2022 Jun 7.

University of Chinese Academy of Sciences (UCAS), Beijing, China.

There are many thyroid diseases affecting people all over the world. Many diseases affect the thyroid gland, like hypothyroidism, hyperthyroidism, and thyroid cancer. Thyroid inefficiency can cause severe symptoms in patients. Read More

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Hyperthyroid cats and their kidneys: a literature review.

Aust Vet J 2022 Jun 16. Epub 2022 Jun 16.

Animal Referral Hospital, Essendon Fields, 72 Hargrave Avenue, Essendon Fields, Victoria, 3041, Australia.

Hyperthyroidism and chronic kidney disease (CKD) are common diseases of geriatric cats, and often occur concurrently. Thus, a thorough understanding of the influence of thyroid function on renal function is of significant value for all feline practitioners. Among other effects, hyperthyroidism causes protein catabolism and increases renal blood flow and glomerular filtration rate (GFR). Read More

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