51,627 results match your criteria Hyperthyroidism


Predictive Value of C2HEST Score for Atrial Fibrillation Recurrence Following Successful Cryoballoon Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation.

Angiology 2022 May 18:33197221102230. Epub 2022 May 18.

Department of Cardiology, 147003Bursa Yüksek İhtisas Training and Research Hospital, İzmir, Turkey.

The C2HEST score ((coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD) [C2, 1 point each]; hypertension [H, 1 point]; elderly [E, age ≥75 years, 2 points]; systolic heart failure [S, 2 points]; thyroid disease [T, hyperthyroidism, 1 point]) has been validated for predicting incidental atrial fibrillation (AF) in both the general population and patients with ischemic stroke. The present study evaluated the performance of this score in predicting AF recurrence in 252 patients following cryoballoon ablation (CRYO) for paroxysmal AF. The AF recurrence rate in 3-12 months following CRYO was 20,2%. Read More

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Using the CHEST Score for Predicting Postoperative Atrial Fibrillation After Cardiac Surgery: A Report From the Western Denmark Heart Registry, the Danish National Patient Registry, and the Danish National Prescription Registry.

J Cardiothorac Vasc Anesth 2022 Apr 6. Epub 2022 Apr 6.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark.

Objectives: New-onset postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery. A targeted approach is necessary for prophylactic handling of the complication. The authors tested the performance of the CHEST score to predict POAF in patients undergoing cardiac surgery. Read More

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Aneurysmal bone cyst of the proximal femur concomitant with Graves' disease and Moyamoya disease: report of a rare case.

J Int Med Res 2022 May;50(5):3000605221097669

Department of Joint Surgery, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong Province, China.

Aneurysmal bone cyst is a type of benign bone pathology with expansile and osteolytic features whose etiology remains unclear. Graves' disease is an autoimmune disease characterized by diffuse goiter and hyperthyroidism. Moyamoya disease is a progressive cerebral vasculopathy. Read More

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Biomarkers and Disease Trajectories Influencing Women's Health: Results from the UK Biobank Cohort.

Phenomics 2022 May 12:1-10. Epub 2022 May 12.

Department of Epidemiology and Health Statistics, School of Public Health and Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Xue Yuan Road 1, University Town, Fuzhou, 350122 China.

Women's health is important for society. Despite the known biological and sex-related factors influencing the risk of diseases among women, the network of the full spectrum of diseases in women is underexplored. This study aimed to systematically examine the women-specific temporal pattern (trajectory) of the disease network, including the role of baseline physical examination indexes, and blood and urine biomarkers. Read More

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Association of Mild Thyroid Dysfunction and Adverse Prognosis Among Chinese Patients With Acute ST Segment Elevation Myocardial Infarction.

Front Endocrinol (Lausanne) 2022 28;13:879443. Epub 2022 Apr 28.

Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Aims: Thyroid hormones widely affect the cardiovascular system, but the effects of mild thyroid dysfunction on the clinical prognosis of patients with acute ST segment elevation myocardial infarction (STEMI) remains unclear. Our aims were to analyze the relations between mild thyroid dysfunction at admission and clinical outcomes in Chinese patients with STEMI.

Methods: A total of 1,176 STEMI patients with the available data of thyroid function and follow-up were analyzed, including 348 patients with mild thyroid dysfunction [subclinical hypothyroidism (n=81), hyperthyroidism (SHyper) (n=51), and low triiodothyronine syndrome (LT3S) (n=216)] and 828 patients with euthyroid function. Read More

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Editorial: Mechanisms and Novel Therapies in Graves' Orbitopathy: Current Update.

Front Endocrinol (Lausanne) 2022 29;13:902591. Epub 2022 Apr 29.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

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Carbimazole-Induced Agranulocytosis in a Previously Stable Patient: A Case Report and Literature Review.

Cureus 2022 Apr 13;14(4):e24115. Epub 2022 Apr 13.

Internal Medicine, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, GBR.

Carbimazole-induced agranulocytosis is a rare condition. A 48-year-old female patient with a history of hyperthyroidism for several years presented with generalized fatigue and chest pain associated with palpitations; the patient was stable on carbimazole therapy. She was previously on carbimazole 15 mg once daily (OD) and, three months later, was reduced to 10 mg OD as symptoms were controlled. Read More

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Hypothalamic AMPK as a possible target for energy balance-related diseases.

Authors:
Miguel López

Trends Pharmacol Sci 2022 May 12. Epub 2022 May 12.

NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela - Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain. Electronic address:

Hypothalamic AMP-activated protein kinase (AMPK) is a canonical regulator of energy balance and metabolism at the whole-body level. This makes this enzyme an attractive target for treating energy balance-related diseases. However, targeting AMPK within the hypothalamus presents a challenge related to the specific cellular biodistribution of the enzyme and the need to use clinically safe methods of administration. Read More

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Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters.

Fertil Steril 2022 May 11. Epub 2022 May 11.

Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark.

Objective: To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters.

Design: Cohort study.

Setting: National birth cohort and health registers. Read More

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Patients with Thyroid Disorder, a Contraindication for Dental Implants? A Systematic Review.

J Clin Med 2022 Apr 25;11(9). Epub 2022 Apr 25.

Department of Odontoestomatology, Faculty of Medicine and Health Sciences, School of Dentistry, University Campus of Bellvitge, University of Barcelona, 08907 Barcelona, Spain.

The thyroid gland is composed of the thyroid follicles, considered to be the functional units of the thyroid gland. The synthesis of the thyroid hormones occurs in these follicles. Triiodothyronine (T3) and thyroxine (T4) are the thyroid hormones and affect metabolic processes all through the body. Read More

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Timing of Graves' Hyperthyroidism Management in Pregnant Women: Impact on the Infant Thyroid Volume.

Nutrients 2022 May 9;14(9). Epub 2022 May 9.

Neonatal and Intensive Care Department, Medical University of Warsaw, Karowa 2, 00-315 Warsaw, Poland.

The thyroid of the fetus of a mother with Graves' disease (GD) is affected by the transplacental passage of both antithyroid drugs (ATDs) and thyroid-stimulating hormone receptor antibodies (TRAb). Thyroid hormone imbalances are harmful for the developing brain. This study aimed to evaluate the impact of the duration of antithyroid drug treatment in hyperthyroid pregnant women with GD on infants' thyroid volume. Read More

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Risk-Benefit Assessment of an Increase in the Iodine Fortification Level of Foods in Denmark-A Pilot Study.

Foods 2022 Apr 28;11(9). Epub 2022 Apr 28.

National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

Iodine deficiency is one of the most common nutritional disorders worldwide. In Denmark, the mandatory iodine fortification of salt of 13 ppm was introduced in 2000 to eradicate mild to moderate iodine deficiency and the fortification level was increased to 20 ppm in 2019. However, the optimal iodine intake is a narrow interval, and the risk of disease increases with intakes both below and above this interval. Read More

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Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves' Orbitopathy.

Int J Mol Sci 2022 May 9;23(9). Epub 2022 May 9.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.

Fibrosis of extraocular muscles (EOMs) is a marker of end-stage in Graves' orbitopathy (GO). To determine the antifibrotic and anti-inflammatory therapeutic effects and the underlying molecular mechanisms of disulfiram (DSF) on perimysial orbital fibroblasts (pOFs) in a GO model in vitro, primary cultures of pOFs from eight patients with GO and six subjects without GO (NG) were established. CCK-8 and EdU assays, IF, qPCR, WB, three-dimensional collagen gel contraction assays, cell scratch experiments, and ELISAs were performed. Read More

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Association of Thyroid Hormone Treatment Intensity With Cardiovascular Mortality Among US Veterans.

JAMA Netw Open 2022 May 2;5(5):e2211863. Epub 2022 May 2.

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor.

Importance: Cardiovascular disease is the leading cause of death in the United States. Synthetic thyroid hormones are among the 3 most commonly prescribed medications, yet studies evaluating the association between the intensity of thyroid hormone treatment and cardiovascular mortality are scarce.

Objective: To evaluate the association between thyroid hormone treatment intensity and cardiovascular mortality. Read More

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Radiofrequency Ablation of Solid Benign Thyroid Nodules.

Tech Vasc Interv Radiol 2022 Jun 12;25(2):100819. Epub 2022 Mar 12.

Dotter Department of Interventional Radiology, Oregon Health and Science University, Portland, OR.

Symptomatic solid benign thyroid nodules may present either as nonfunctioning nodules causing compressive symptoms or as hyperfunctioning nodules causing symptoms of hyperthyroidism. While surgical resection or radioiodine ablation of these nodules can be performed, percutaneous radiofrequency ablation (RFA) of benign solid thyroid nodules has been shown to be a safe and effective alternative in select patients. Preprocedural evaluation should include a history focusing on signs and symptoms of thyroid dysfunction, a physical exam, thyroid ultrasound, thyroid function tests, and discussion of key intraprocedural details with the patient such as the anesthesia plan and risks. Read More

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Takotsubo cardiomyopathy in the setting of thyroid storm.

BMJ Case Rep 2022 May 12;15(5). Epub 2022 May 12.

Cardiology, Northern Hospital Epping, Epping, Victoria, Australia.

A woman in her 50s with a background of chronic obstructive pulmonary disease secondary to smoking presented with intermittent chest tightness, dyspnoea and vomiting for 4 days. A presumed diagnosis of acute coronary syndrome (ACS) was made based on dynamic ischaemic ECG changes and elevation in high-sensitivity cardiac troponin T levels. She underwent emergent coronary angiography which demonstrated mild coronary artery disease with left ventriculography suggestive of mid-wall variant Takotsubo cardiomyopathy. Read More

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A prospective study among neonates born to mothers with active or past Graves disease.

Gynecol Endocrinol 2022 May 12:1-4. Epub 2022 May 12.

Department of Pediatrics, Section of Neonatology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

Objective: The aim of this prospective study was to describe demographic and clinical characteristics of neonates born to mothers with active or past Graves disease and to assess compliance since implementation of a new protocol in our center.

Methods: We prospectively followed up neonates born to mothers with active or past Graves disease in a tertiary hospital in Spain between August 2019 and September 2021 according to our protocol. We reviewed maternal and neonatal history of these neonates, and we followed up newborns at risk of neonatal hyperthyroidism. Read More

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Venous Thromboembolism and Thymic Hyperplasia in the Setting of Silent Graves' Disease.

Cureus 2022 Apr 7;14(4):e23935. Epub 2022 Apr 7.

Internal Medicine, University of Central Florida College of Medicine/HCA Florida North Florida Hospital, Gainesville, USA.

Venous thromboembolism is a common, yet serious life-threatening condition that has many well-recognized associations which include but are not limited to pregnancy, polycythemia, trauma, immobility, and malignancy. The pathophysiology behind the pro-coagulant effects of hyperthyroidism has been well established; however, there are no current guidelines regarding deep venous thrombosis (DVT) surveillance in patients with hyperthyroidism. In this report, we discuss the case of a 36-year-old female with no significant past medical history (PMH) with the exception of a 15 pack-year smoking history, who presented to us with an extensive, rapidly-progressing lower extremity DVT. Read More

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Giant cervical goiter in Hashimoto's thyroiditis: A case report.

J Int Med Res 2022 May;50(5):3000605221096379

The First Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China.

A giant cervical goiter, defined as a thyroid mass larger than 8 cm in diameter, is usually a nodular or adenomatous goiter. A giant cervical goiter can also be caused by hyperthyroidism (i.e. Read More

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Intraocular pressure improvement in patients receiving teprotumumab for the treatment of thyroid eye disease: a case series.

J Med Case Rep 2022 May 10;16(1):195. Epub 2022 May 10.

Southern California Eye Physicians and Surgeons, 1111 S. Fair Oaks Ave., Pasadena, CA, 91105, USA.

Background: Teprotumumab is a novel treatment that reduces inflammation and symptoms caused by thyroid eye disease. There are limited data on teprotumumab's effect on intraocular pressure.

Case Presentation: We report nine patients diagnosed with thyroid eye disease whose intraocular pressure decreased during teprotumumab treatment for 8 weeks: patient 1, a 67-year-old Hispanic woman; patient 2, an 86-year-old African-American man; patient 3, a 71-year-old Caucasian woman; patient 4, a 72-year-old Hispanic woman; patient 5, a 65-year-old Caucasian woman; patient 6, a 54-year-old Caucasian man; patient 7, a 54-year-old Asian man; patient 8, a 31-year-old Asian woman; patient 9, a 60-year-old Caucasian woman. Read More

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Predictors of Hypothyroidism Following Empirical Dose Radioiodine Treatment In Patients with Toxic Adenoma and Toxic Multinodular Goitre: Real-Life Experience.

Endocr Pract 2022 May 7. Epub 2022 May 7.

Prof., Department of Nuclear Medicine, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.

Objective: We aimed to determine the factors predicting hypothyroidism after the radioactive iodine (RAI) treatment in patients with toxic adenoma (TA) and toxic multinodular goiter (TMNG).

Methods: We collected the retrospective data of 237 patients with TMNG/TA who consecutively received RAI treatment between 2014 and 2020 at two medical centers. Patients who received the second RAI treatment and whose medical records could not be accessed were excluded from the study. Read More

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Robot-Assisted Orbital Fat Decompression Surgery: First in Human.

Transl Vis Sci Technol 2022 May;11(5)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Purpose: To explore the safety and feasibility of robot-assisted orbital fat decompression surgery.

Methods: Ten prospectively enrolled patients (18 eyes) with Graves' ophthalmopathy underwent robot-assisted orbital fat decompression surgery with the da Vinci Xi surgical system. Intraoperative blood loss, operative time, and complications were recorded. Read More

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Co-occurrence of relapsing polychondritis and autoimmune thyroid diseases.

Orphanet J Rare Dis 2022 05 10;17(1):101. Epub 2022 May 10.

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, 230-0045, Japan.

Background: Relapsing polychondritis (RP) is a rare inflammatory disease characterized by recurrent inflammation and destruction of cartilaginous tissues. RP has characteristics of autoimmune disease and some reports have noted co-occurrence with autoimmune thyroid disease (AITD), consisting of Graves' disease (GD) and Hashimoto thyroiditis (HT). However, there have been no detailed studies on the co-occurrence of RP and AITD. Read More

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Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid.

Case Rep Med 2022 29;2022:5827664. Epub 2022 Apr 29.

Department of Endocrinology, Changi General Hospital, Singapore.

A previously well 32-year-old Chinese male presented with acute bilateral upper and lower limb paralysis upon waking, ten days after the onset of COVID-19 infection. Examination revealed areflexia over all four limbs, associated with reduced muscle strength, but no sensory or cranial nerve deficit. Initial concern was Guillain-Barre syndrome given the acute flaccid paralysis following COVID-19 infection. Read More

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Comparative Clinicopathological Evaluation of the Ocular Surface in Newly Diagnosed Patients of Hyperthyroidism and Hypothyroidism Compared to Healthy Subjects.

Cureus 2022 Apr 6;14(4):e23890. Epub 2022 Apr 6.

Pathology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Introduction Thyroid eye disease is a multifactorial disorder affecting the tear film and ocular surface, which leads to dry eye. The aim of the study is to evaluate the tear function test and ocular surface changes clinically and to correlate pathologically using impression cytology in recently diagnosed cases of thyroid dysfunction, including both hyperthyroid and hypothyroid patients, and to compare the results with healthy subjects. Methods This was a cross-sectional analytical study. Read More

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Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.

Front Endocrinol (Lausanne) 2022 22;13:860880. Epub 2022 Apr 22.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Hashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of this study was to investigate, in a cohort of HT patients: a) the prevalence of APCA in an attempt to define their clinical phenotype and b) any possible associations of APCA with other autoimmune diseases and malignancies. Read More

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Offspring conceived through ART have normal thyroid function in adolescence and as young adults.

Hum Reprod 2022 May 8. Epub 2022 May 8.

Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.

Study Question: Are there differences in thyroid function between adolescents and young adults conceived with and without ART?

Summary Answer: This study demonstrated no evidence of clinically relevant differences in thyroid function between adolescents and young adults conceived with and without ART.

What Is Known Already: Studies to date have reported an increase in subclinical hypothyroidism in offspring conceived after ART. It has been suggested that the increase in maternal estrogen (E2) after fresh embryo transfers could affect thyroid function of the offspring. Read More

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Utility of a canine TSH assay for diagnosis and monitoring of feline hyperthyroidism.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2022 Apr 6;50(2):93-100. Epub 2022 May 6.

Department for Small Animals and Horses, University of Veterinary Medicine, Division of small animal internal medicine.

Objective: This retrospective study was initiated to evaluate the utility of TSH measurements using a common canine TSH assay to diagnose and monitor feline hyperthyroidism after radioiodine or thyreostatic drug treatment.

Material And Methods: The electronic database of the University of Veterinary Medicine Vienna was searched for combined TSH and T4 measurements. 217 pairs of TSH and T4 from 136 cats with possible hyperthyroidism were assigned to group A (untreated; n = 24) and B (treated; n = 193). Read More

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CTLA-4 POLYMORPHISM ALONG WITH PROINFLAMMATORY CYTOKINES IN AUTOIMMUNE THYROIDITIS DISEASE.

Wiad Lek 2022 ;75(3):577-583

UNIVERSITY OF AL-QADISIYAH, AL DIWANIYAH, IRAQ.

Objective: The aim: Evaluating serum concentration of IL-17 and IL-23 in autoimmune thyroiditis patient and control group along with the role of CTLA-4 rs3087243 gene polymorphism.

Patients And Methods: Materials and methods: A case control study was conducted in 30 HT (Hashimoto's thyroiditis), 30 GD (Graves' disease) who attended the consultant clinic for thyroiditis in AL-Diwaniyah teaching hospital and in 30 people as control group. Blood samples were processed for measurement of serum IL-17 and IL-23 using ELISA test. Read More

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Letter to the Editor from Banigé and Polak: "Population-based TSH screening of newborns for hyperthyroidism: it may be feasible, but is it justified?"

J Clin Endocrinol Metab 2022 May 6. Epub 2022 May 6.

Pediatric Endocrinology, Gynaecology and Diabetology Department, Centre Régional de Dépistage Néonatal (CRDN), Hôpital Universitaire Necker-Enfants Malades, AP-HP, Université de Paris, INSERM U1016, Centre for Rare Endocrine Diseases affecting Growth and Development, IMAGINE Institute, Paris, France.

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