47,666 results match your criteria Hyperthyroidism


Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs.

J Gerontol A Biol Sci Med Sci 2019 Feb 16. Epub 2019 Feb 16.

Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany.

Clinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, 20 months). Read More

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http://dx.doi.org/10.1093/gerona/glz040DOI Listing
February 2019

Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Int J Radiat Oncol Biol Phys 2019 Feb 12. Epub 2019 Feb 12.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.

Background: The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.

Methods: Utilizing the Childhood Cancer Survivor Study, a cohort of five-year survivors of childhood cancer diagnosed at hospitals in the United States and Canada between 1970 and 1986, the occurrence of hyperthyroidism through 2009 was ascertained among 12,183 survivors based on serial questionnaires. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193020
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.009DOI Listing
February 2019
1 Read

Prevalence of Suspicious Ultrasound Features in Hot Thyroid Nodules.

Fed Pract 2018 May;35(Suppl 4):S46-S48

is an Internal Medicine Resident at the University of California Davis Medical Center in Sacramento. was a Staff Physician at the time the article was written, is a Staff Physician, and is an Assistant Chief of Medical Services and Chief of Endocrine Section, all at the Veterans Affairs Northern California Health Care System in Mather. is an Associate Health Sciences Clinical Professor, and Dr. Swislocki is a Professor of Medicine in the Division of Endocrinology, both at University of California Davis Medical Center.

Ultrasound for patients with hyperthyroidism and thyroid hot nodules is of limited value, given the high prevalence of suspicious findings, but may be useful for patients with high-risk factors. Read More

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See-Saw Relationship and its Reversal after Immunotherapy in a Case of Graves' Disease with Coexisting Myasthenia Gravis.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):136-138

Department of Neurology, Stanley Medical College, Chennai, Tamil Nadu, India.

The unique association of myasthenia gravis (MG) with Graves' disease in clinical practice emphasizes that one autoimmune disease can coexist with another or many. The relationship between these two entities has remained controversial till date. Some authors have reported a see-saw relationship between these two entities, MG waning with hyperthyroidism and waxing with treatment of hyperthyroidism. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337967PMC
February 2019

Hyperfunctioning Papillary Microcarcinoma Diagnosed by 124I PET/Ultrasound Fusion Imaging.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.

A 49-year-old woman presented with a multinodular goiter, causing local symptoms and hyperthyroisdism. Besides a hypofunctioning benign nodule (TIRADS 3, benign in FNAC), the conventional diagnostic revealed another small hyperfunctioning nodule with suspicious ultrasound features (TIRADS 4C). To rule out a trapping-only nodule and topographical misalignments, a I PET/ultrasound fusion was performed and confirmed elevated iodine uptake within the suspicious nodule. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002503DOI Listing
February 2019

Erratic movement disorders disclosing Graves' disease and paralleling thyroid function but not autoantibody levels.

J Int Med Res 2019 Feb 14:300060518816873. Epub 2019 Feb 14.

4 Neurology Unit, Department of Internal Medicine and Geriatrics, Valais Hospital, Sion, Switzerland.

Graves' disease (GD) is an autoimmune pathology characterized by hyperthyroidism and the presence of specific anti-thyroid antibodies. Neurological symptoms such as seizures, cognitive impairment, and tremor can be observed during the course of GD, but more complex movement disorders such as chorea and myoclonus are less frequent. The mechanisms underlying movement disorders in GD are not fully understood. Read More

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http://dx.doi.org/10.1177/0300060518816873DOI Listing
February 2019

Changes in thyroid and renal function after bilateral thyroidectomy in cats.

J Vet Intern Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Science and Services, Small Animal Medicine and Surgery Group, The Royal Veterinary College, Hertfordshire, United Kingdom.

Background: Iatrogenic hypothyroidism might worsen the prognosis of cats with azotemic CKD after thyroidectomy. Varying thyroxine concentrations influence utility of creatinine in assessing renal function. Symmetric dimethylarginine (SDMA) has limited studies in cats with changing thyroid status. Read More

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http://dx.doi.org/10.1111/jvim.15450DOI Listing
February 2019

Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

Institute of Biomedical Sciences, University of Sao Paulo, Department of Physiology and Biophysics, Sao Paulo, SP, Brazil ;

Background: The secretion of pituitary hormones oscillates throughout the 24 h period, indicating that circadian clock-mediated mechanisms regulate this process in the gland. Additionally, pituitary hormone synthesis has been shown to be altered in hypo- and hyperthyroidism. Although thyroid hormones can modulate the other peripheral clocks, the interaction between thyroid hormone levels and circadian clock gene expression in the anterior pituitary has yet to be elucidated. Read More

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http://dx.doi.org/10.1089/thy.2018.0578DOI Listing
February 2019
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[Immunotropic reaction onto balneotherapy by mineral water «naftusia» of women with hyperplasia of the thyroid gland and non-calcular cholecystitis].

Authors:
Oksana L Fuchko

Wiad Lek 2018 ;71(9):1690-1694

Higher State Educational Institution Of Ukraine «Uzhhorod National University», Uzhhorod, Ukraine.

Objective: Introduction: Hyperplasia of the thyroid gland is recetly widespread, especially among women, with pathology. At structural changes of a gland there are various types of violations of the hormonal status of the organism - from hyperthyroidism through euthyroidism to hypothermia. The aim: The article aims at investigation of the peculiarities of the influence of mineral water "Naftusia" on the immunological status of women with non-calcular cholecystitis and hyperplasia of the thyroid gland, as well as the substantiation of the possibilities of using balneotherapy in the treatment of this pathology on the basis of the obtained data. Read More

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January 2018
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Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
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Monitoring of salt iodisation programme in Iran; Health outcomes, shortages and perspective.

J Trace Elem Med Biol 2019 Mar 10;52:6-11. Epub 2018 Nov 10.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Centre for Water Quality Research (CWQI), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Iodine deficiency disorders include a wide range of metabolic and nonmetabolic disorders including goiter. To control IDDs, the World Health Organization and responsible agencies in countries established daily iodine uptake. Almost all the countries in the world provide the required iodine through salt iodisation. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.004DOI Listing
March 2019
1 Read

Effects of controlled ovarian stimulation on thyroid stimulating hormone in infertile women.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 30;234:207-212. Epub 2019 Jan 30.

Department of Medical Research, Shijiazhuang First Hospital, Hebei Medical University, China.

Objective: To study the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) on thyroid function in euthyroid patients of in vitro fertilization (IVF)/ intracytoplasmic sperm injection of embryo transfer (ICSI-ET) and to investigate the timing and alteration of thyroid stimulating hormone (TSH) during controlled ovarian stimulation(COS).

Materials And Methods: Euthyroid patients scheduled for IVF/ICSI were enrolled. Euthyroidism was defined as having no history of hypothyroidism with normal TSH before IVF. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.025DOI Listing
January 2019
1 Read
1.627 Impact Factor

[Apparent thyrotoxicosis in a patient with multiple sclerosis: biochemical assay interference due to high dose biotin use].

Ned Tijdschr Geneeskd 2018 Feb 14;162. Epub 2018 Feb 14.

Stichting Certe Medische Diagnostiek en Advies, divisie Klinische Chemie, Locatie Laboratorium Leeuwarden.

Background: Supraphysiological doses of biotin are being tested in patients with multiple sclerosis. Biotin can cause interference with laboratory assessment of thyroid function, and therefore give a false suggestion of thyrotoxicosis.

Case Description: A 64-year-old patient was referred for assessment of thyrotoxicosis, due to Graves' disease. Read More

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February 2018
1 Read

Visfatin, PON-1 Levels in Iraqi Hyperthyroidism Patient's with Dyslipidemia.

Indian J Clin Biochem 2019 Jan 14;34(1):101-107. Epub 2017 Nov 14.

Chemistry Department, College of Education for Pure Science/Ibn Al-Haitham, University of Baghdad, P.O. Box 4150, AI-Adhamiyah/Anter Square/Baghdad, Iraq.

In the study, it is aimed to research the likely role of visfatin in hyperthyroid and subclinical hyperthyroid status related to dislipidemia, after determining the visfatin and PON-1 levels thirty healthy individuals were enrolled in this study as control group and thirty hyperthyroidism patient's with dyslipidemia they were treated with. The subjects aged ranged (30-50) years and with BMI (25-29) kg/m. Serum was used in determination of lipid profile total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), thyroid threonine (T3) and thyroxin (T4), thyroid stimulating hormone (TSH), visfatin and paraoxonase-1 (PON-1). Read More

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http://dx.doi.org/10.1007/s12291-017-0717-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346613PMC
January 2019
1 Read

Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma.

Endocr Metab Immune Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Gaziosmanpasa University, Faculty of Medicine, Department of Internal Medicine 60200 Tokat. Turkey.

Introduction: Thyroid hormones are essential for the normal development, differentiation, metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates mean platelet size and reflects platelet production rate and stimulation. Increased platelet size has been observed in association with known cardiovascular risk factors. Read More

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http://dx.doi.org/10.2174/1871530319666190206125545DOI Listing
February 2019
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Genetics Of Atrial Fibrilation: In Search Of Novel Therapeutic Targets.

Cardiovasc Hematol Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Cardiovascular Development Group, Department of Experimental Biology, University of Jaen. Spain.

Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from 2% in the general population and raising up to 10-12% in 80+ years. Genetic analyses of AF familiar cases have identified a series of point mutations in distinct ion channels, supporting a causative link. However, these genetic defects only explain a minority of AF patients. Read More

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http://dx.doi.org/10.2174/1871529X19666190206150349DOI Listing
February 2019

[Newborn of mothers with Graves' disease].

Rev Chil Pediatr 2018 Dec;89(6):753-760

Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: The most frequent cause of congenital hyperthyroidism is maternal Graves' disease (GD), in which thyroid stimulating hormone (TSH) receptor antibodies (TRAb) cross the placenta and stimulate the fetal and/or neonatal TSH receptor to produce thyroid hormones. Thyroid dys function in these patients is confirmed by increased thyroxine (T4) and triiodothyronine (T3) levels accompanied by suppressed TSH levels.

Objective: To characterize the clinical and biochemical evo lution of newborns of mothers with GD and to suggest recommendations regarding treatment and follow-up. Read More

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http://dx.doi.org/10.4067/S0370-41062018005001002DOI Listing
December 2018
1 Read

Expression and activity of lipid and oxidative metabolism enzymes following elevated temperature exposure and thyroid hormone manipulation in juvenile lake whitefish (Coregonus clupeaformis).

Gen Comp Endocrinol 2019 Feb 2;275:51-64. Epub 2019 Feb 2.

Department of Biology, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada. Electronic address:

Temperature has unequivocal effects on several aspects of fish physiology, but the full extent of its interaction with key endocrine signaling systems to influence metabolic function remains unknown. The aim of the current study was to assess the individual and combined effects of elevated temperature and hyperthyroidism on hepatic metabolism in juvenile lake whitefish by quantifying mRNA abundance and activity of key metabolic enzymes. Fish were exposed to 13 (control), 17 or 21 °C for 0, 4, 8 or 24 days in the presence or absence of low-T (1 µg × g body weight) or high-T (10 µg × g body weight) treatment. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.02.001DOI Listing
February 2019
2 Reads

Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 5:194599819829052. Epub 2019 Feb 5.

1 Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.

Objective: The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies. Read More

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http://dx.doi.org/10.1177/0194599819829052DOI Listing
February 2019
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Predictors of Initial and Sustained Remission in Patients Treated with Antithyroid Drugs for Graves' Hyperthyroidism: The RISG Study.

J Thyroid Res 2019 3;2019:5945178. Epub 2019 Jan 3.

Dept. of Endocrinology and Internal Medicine, Herlev Hospital, 2730 Copenhagen, Denmark.

To study predictors of attaining (part 1) and sustaining (part 2) remission in patients with Graves' hyperthyroidism (GH) treated with antithyroid drugs (ATD). In the prospective first part, the included patients were treated with ATD until a prespecified definition of remission (thyrotropin > 0.4 mU/L and TSH-receptor antibodies (TRAb) ≤ 1. Read More

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http://dx.doi.org/10.1155/2019/5945178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335719PMC
January 2019

Local hyperthyroidism promotes pancreatic acinar cell proliferation during acute pancreatitis.

J Pathol 2019 Feb 4. Epub 2019 Feb 4.

Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland.

Proliferation of pancreatic acinar cells is a critical process in the pathophysiology of pancreatic diseases, because limited or defective proliferation is associated with organ dysfunction and patient morbidity. In this context, elucidating the signalling pathways that trigger and sustain acinar proliferation is pivotal to develop therapeutic interventions promoting the regenerative process of the organ. In this study we used genetic and pharmacological approaches to manipulate both local and systemic levels of thyroid hormones to elucidate their role in acinar proliferation following caerulein-mediated acute pancreatitis in mice. Read More

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http://dx.doi.org/10.1002/path.5247DOI Listing
February 2019
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Nivolumab Induced Thyroid Dysfunction: Unusual Clinical Presentation and Challenging Diagnosis.

Front Endocrinol (Lausanne) 2018 17;9:813. Epub 2019 Jan 17.

Unit of Internal Medicine and Endocrinology, ICS Maugeri IRCCS, University of Pavia, Pavia, Italy.

In recent years, immune checkpoint inhibitors (ICIs) had a great impact in cancer therapy. ICIs display a peculiar toxicity profile, which is characterized by autoimmune-like manifestations against multiple organs, including endocrine glands. We hereby report the case history of two patients who experienced nivolumab-induced endocrine immuno-related adverse events (irAEs). Read More

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http://dx.doi.org/10.3389/fendo.2018.00813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345097PMC
January 2019
1 Read

Active Moderate-to-Severe Graves' Orbitopathy in a Patient With Type 2 Diabetes Mellitus and Vascular Complications.

Front Endocrinol (Lausanne) 2018 17;9:810. Epub 2019 Jan 17.

Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). Diabetes mellitus (DM) has been reported to be a risk factor in patients with GO. Moreover, GO can be more frequent and severe in type 2 diabetes patients. Read More

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http://dx.doi.org/10.3389/fendo.2018.00810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344418PMC
January 2019
1 Read

[Update Graves' disease 2019].

Dtsch Med Wochenschr 2019 Feb 31;144(3):152-155. Epub 2019 Jan 31.

Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf.

Diagnosis:  Also accordingly to the recent European Thyroid Association Guidelines 2018, TSH receptor antibody (TRAb) measurement is highly sensitive and specific for the detection of Graves' disease (GD) and to distinguish from autoimmune thyroiditis (AIT). Bioassays are used for distinguishing stimulating from blocking antibodies and are used for scientific questions.

Therapy:  According to the current guidelines - and with exception for pregnant women - the use of thiamazol/carbimazole is generally favored from propylthiouracil (PTU). Read More

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http://dx.doi.org/10.1055/a-0660-6046DOI Listing
February 2019
14 Reads

Thyroid function in patients with Prader-Willi syndrome: an Italian multicenter study of 339 patients.

J Pediatr Endocrinol Metab 2019 Feb;32(2):159-165

Department of Medical and Surgical Sciences of Mother, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.

Background Prader-Willi syndrome (PWS) is a genetic disorder due to loss of expression of paternally transcribed genes of the imprinted region of chromosome 15q11-13. PWS is characterized by peculiar signs and symptoms and many endocrine abnormalities have been described (growth hormone deficiency, hypogonadotropic hypogonadism). The abnormalities of thyroid function are discussed in literature and published data are discordant. Read More

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http://dx.doi.org/10.1515/jpem-2018-0388DOI Listing
February 2019
2 Reads
0.711 Impact Factor

Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases: A Mendelian Randomization Study.

Circ Genom Precis Med 2019 Jan 31. Epub 2019 Jan 31.

Department of Public Health and Primary Care, University of Cambridge, UNITED KINGDOM.

Background: Subclinical thyroid dysfunction, defined as thyroid-stimulating hormone (TSH) levels outside the reference range with normal free thyroxine levels in asymptomatic patients, is associated with alterations in cardiac hemodynamics. We used Mendelian randomization to assess the role of thyroid dysfunction for cardiovascular disease.

Methods: Single-nucleotide polymorphisms associated with thyroid function were identified from a genome-wide association meta-analysis in up to 72 167 individuals. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002468DOI Listing
January 2019

Syndrome of thyrotoxicosis. Differential diagnosis and treatment.

Ter Arkh 2018 Nov;90(10):4-23

Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Since the middle of the twentieth century, there has been a significant change in methods of the diagnosis and treatment of thyroid diseases with thyrotoxicosis syndrome. Previously doctors did not have trouble just with diagnosing diseases that occur with a typical clinical presentation (the Merzeburg triad, a multinodal goiter with fibrillation) because of no possible to determine thyroid hormones. Then in the early 70s years the appearance of immunological methods for estimating hormones in the blood has led to significant changes in our understanding of the variants of thyroid pathology with thyrotoxicosis (TT). Read More

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http://dx.doi.org/10.26442/terarkh201890104-13DOI Listing
November 2018
1 Read

Hypothalamic energy regulatory peptides in chronic kidney disease.

Ther Apher Dial 2019 Jan 30. Epub 2019 Jan 30.

Department of Endocrinology, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Loss of appetite affects one-third of patients with chronic kidney disease (CKD) and is the leading cause of malnutrition in this population. Orexigenic Agouti-related peptide (AgRP) with neuropeptide-Y (NPY) and anorexigenic melanocyte-stimulating hormone-α (MSH-α) with cocaine amphetamine-regulated transcript (CART) are known to regulate appetite. In this study, we aimed to evaluate the levels of these peptides in CKD patients comparing healthy subjects and demonstrate the effects of dialysis treatment and erythropoiesis-stimulating agents (ESA) therapy. Read More

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http://dx.doi.org/10.1111/1744-9987.12798DOI Listing
January 2019
2 Reads
1.532 Impact Factor

Screening of congenital hyperthyroidism in Morocco: a pilot study.

East Mediterr Health J 2019 Jan 23;24(11):1066-1073. Epub 2019 Jan 23.

Service de la Santé publique, Direction régionale de la Santé de Fès-Boulemane, Fès (Maroc).

Background: In Morocco we have no reliable information on the incidence of congenital hypothyroidism (HC).

Aims: The aim of our study was to explore the feasibility of a neonatal screening program for this disease in Morocco.

Methods: We conducted a screening campaign in the HC 15 615 newborns in the wilaya of Fez in north-central Morocco. Read More

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http://dx.doi.org/10.26719/2018.24.11.1066DOI Listing
January 2019
2 Reads

Pattern and Presentation of Thyro-Cardiac Disease among Patients with Hyperthyroidism Attending a Tertiary Hospital in Ethiopia: A Cross Sectional Study.

Ethiop J Health Sci 2019 Jan;29(1):887-894

Department of Internal Medicine, Cardiology Unit, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Thyro-cardiac disease describes the existence of a combination of thyroid toxicity and significant heart disease in an individual patient. The frequent manifestations of thyro-cardiac disease are hypertension, atrial flutter or fibrillation, pulmonary hypertension and dilated cardiomyopathy. The aim of the study was to determine the pattern and presentation of cardiovascular diseases in patients with hyperthyroidism on follow-up at St. Read More

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http://dx.doi.org/10.4314/ejhs.v29i1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341434PMC
January 2019
1 Read

A case with an unusual cause of syncope: Thyrotoxicosis.

Am J Emerg Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Emergency Medicine, Kaiser Permanente Emergency Medicine Residency, San Diego, CA, USA. Electronic address:

Syncope is a common emergency department (ED) chief complaint, with many known but also unknown causes. Here we present a novel ED presentation of a young woman with new-onset hyperthyroidism that masqueraded as a syncopal event with head trauma. A 21-year-old woman arrived in the ED with head trauma as the result of seemingly unprovoked syncope, due to her history as well as the nature of her trauma. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.018DOI Listing
January 2019
1 Read

The Prevalence of Thyroid Disorders in Patients With Vitiligo: A Systematic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2018 15;9:803. Epub 2019 Jan 15.

Key Lab of Immunodermatology, Ministry of Health, Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.

Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. The PubMed, Cochrane Library, EMBASE, CNKI (China National Knowledge Infrastructure), Chongqing VIP database, and Wanfang database from inception to August 2, 2018 were systematically searched. Read More

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http://dx.doi.org/10.3389/fendo.2018.00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340922PMC
January 2019
1 Read

Simultaneous presentation of thyroid storm and diabetic ketoacidosis in a previously healthy 21-year-old man.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.

A 21-year-old young man with no history of diabetes or thyroid disease presented to the emergency department with simultaneous thyroid storm and diabetic ketoacidosis. Notable findings on admission were a ventricular rate of 235 beats/min, tachypnoea, tremors, polydipsia and a lack of fever. Due to the unusual constellation of symptoms, diagnosis was only possible after initial laboratory results came back. Read More

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http://dx.doi.org/10.1136/bcr-2018-227554DOI Listing
January 2019
1 Read

Hormonal and psychological factors in nausea and vomiting during pregnancy.

Psychol Med 2019 Jan 30:1-8. Epub 2019 Jan 30.

Department of Medical and Clinical Psychology,Tilburg University,Tilburg,The Netherlands.

Background: The aetiology of nausea and vomiting during pregnancy (NVP) is multifactorial, but the relative contribution of biological and psychological determinants is insufficiently understood. We examined the association of human chorionic gonadotropin (hCG), thyroid hormones (thyroid-stimulating hormone and thyroxin) and psychological factors with NVP.

Methods: Blood chemistry and psychological measures were obtained in 1682 pregnant women participating in the Holistic Approach to Pregnancy and the first Postpartum Year (HAPPY) study between 12 and 14 weeks of gestation. Read More

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https://www.cambridge.org/core/product/identifier/S003329171
Publisher Site
http://dx.doi.org/10.1017/S0033291718004105DOI Listing
January 2019
6 Reads

Independent Association of Serum Fibroblast Growth Factor 21 Levels With Impaired Liver Enzymes in Hyperthyroid Patients.

Front Endocrinol (Lausanne) 2018 14;9:800. Epub 2019 Jan 14.

Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Fibroblast growth factor 21 (FGF21) is identified as a potential biomarker for liver diseases. However, information is limited regarding serum FGF21 and impaired liver function in hyperthyroidism. We aim to determine the potential association of serum FGF21 levels with impaired liver enzymes in hyperthyroid patients. Read More

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http://dx.doi.org/10.3389/fendo.2018.00800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339876PMC
January 2019
1 Read

Propranolol: A 50-Year Historical Perspective.

Authors:
A V Srinivasan

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):21-26

Former Professor of Neurology and Head - Institute of Neurology, Madras Medical College, Chennai, Emeritus Professor - The Tamil Nadu Dr. M.G.R. Medical University, Adjunct Professor - Indian Institute of Technology (IIT - Chennai), Tamil Nadu, India.

Propranolol is a beta-adrenergic receptor antagonist that was developed by the British scientist Sir James Black primarily for the treatment of angina pectoris, more than 50 years ago. It was not long before several other cardiovascular as well as noncardiovascular therapeutic uses of propranolol were discovered. Propranolol soon became a powerful tool for physicians in the treatment of numerous conditions such as hypertension, cardiac arrhythmias, myocardial infarction, migraine, portal hypertension, anxiety, essential tremors, hyperthyroidism, and pheochromocytoma. Read More

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http://dx.doi.org/10.4103/aian.AIAN_201_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327687PMC
January 2019
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The role of Dickkopf-1 in thyroid hormone-induced changes of bone remodeling in male mice.

Endocrinology 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine III, Technische Universität Dresden Medical Center, Dresden, Germany.

Background: Thyroid hormones are critical regulators of bone homeostasis, but their mechanisms of action remain incompletely understood. Exogenously induced hyper- and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), which is a determinant of bone mass. In this study, we assessed the role of Dkk1 in thyroid hormone- induced changes in bone using conditional Dkk1 knockout mice. Read More

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http://dx.doi.org/10.1210/en.2018-00998DOI Listing
January 2019
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Knowledge of Thyroid Eye Disease in Graves' Disease Patients With and Without Orbitopathy.

Thyroid 2019 Jan 28. Epub 2019 Jan 28.

University of Birmingham, School of Clinical and Experimental Medicine , IBR Building 2nd floor , College of Medical and Dental Sciences , University of Birmingham , Birmingham, United Kingdom of Great Britain and Northern Ireland , B152TT ;

Background Thyroid Eye Disease (TED) develops in around 25% of those with Graves' Disease (GD). Patients with TED may present late to ophthalmologists, when debilitating orbital inflammatory changes have already occurred. The reasons for this are multifactorial, but poor knowledge of TED in GD patients may be contributory. Read More

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http://dx.doi.org/10.1089/thy.2018.0665DOI Listing
January 2019
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Increased Risk of Thyroid Dysfunction Among Patients With Rheumatoid Arthritis.

Front Endocrinol (Lausanne) 2018 11;9:799. Epub 2019 Jan 11.

Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.

Thyroid dysfunction seems to be common among rheumatoid arthritis (RA) patients, but the risk of thyroid dysfunction in RA has not been well-defined. We performed a case-control study of 65 RA patients and 550 matched non-RA subjects to assess the risk of thyroid dysfunction among Chinese RA patients. A systematic review and meta-analysis was also conducted to comprehensively define the relationship between RA and thyroid dysfunction. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00799
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http://dx.doi.org/10.3389/fendo.2018.00799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336701PMC
January 2019
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Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients.

Front Endocrinol (Lausanne) 2018 9;9:793. Epub 2019 Jan 9.

Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Recent studies have shown that growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) superfamily, plays an important role in appetite, type 2 diabetes, and cardiovascular diseases. Since thyroid hormone has pleiotropic effects on whole-body energy metabolism, we aimed to explore the effect of thyroid hormone on circulating GDF15 levels in humans and GDF15 genes expression in C57BL/6 mice. A total of 134 hyperthyroid patients and 105 healthy subjects were recruited. Read More

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http://dx.doi.org/10.3389/fendo.2018.00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333670PMC
January 2019
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Long-term outcome of hyperthyroidism diagnosed in childhood and adolescence: a single-centre experience.

J Pediatr Endocrinol Metab 2019 Feb;32(2):151-157

Paediatric Department, University Hospital of Leicester - Leicester Royal Infirmary, Leicester, UK.

Background The objective of the study was to evaluate the long-term outcome of paediatric-onset hyperthyroidism with follow-up into adulthood and to identify any early predictors of a need for definitive therapy (DT). Methods In a retrospective analysis of patients diagnosed with hyperthyroidism under the age of 18 years and at follow-up, a comparison was made by categorising them into those who underwent definitive therapy (DT group), i.e. Read More

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http://dx.doi.org/10.1515/jpem-2018-0385DOI Listing
February 2019
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Determination of risk factors causing hypocalcaemia after thyroid surgery.

Asian J Surg 2019 Jan 23. Epub 2019 Jan 23.

Department of General Surgery, Erciyes University Medical Faculty Hospital, Turkey. Electronic address:

Objective: The most common complication after thyroid surgery is hypocalcaemia and it sometimes leads to problems that are difficult to correct in patients. The present study was aimed to determine the risk factors causing the development of hypocalcaemia after thyroid surgery.

Methods: 818 adult patients were included in the study. Read More

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http://dx.doi.org/10.1016/j.asjsur.2018.12.009DOI Listing
January 2019
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Immune-related adverse events predict the therapeutic efficacy of anti-PD-1 antibodies in cancer patients.

Eur J Cancer 2019 Jan 22;109:21-27. Epub 2019 Jan 22.

Medical Oncology Department, Instituto de Investigación Sanitaria la Princesa, HU La Princesa, Madrid, Spain. Electronic address:

Background: Cancer immune therapy has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate autoimmune-related disorders in some patients. We have attempted to establish whether the incidence of irAEs after the use of anti-PD-1 antibodies nivolumab or pembrolizumab in advanced malignancies is associated with anti-PD-1 treatment efficacy.

Patients And Methods: We studied patients treated with single-agent nivolumab or pembrolizumab for advanced cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183145
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http://dx.doi.org/10.1016/j.ejca.2018.10.014DOI Listing
January 2019
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Challenging diagnosis of thyroid hormone resistance initially as Hashimoto's thyroiditis.

J Pediatr Endocrinol Metab 2019 Feb;32(2):203-206

Department of Pediatrics, Division of Pediatric Endocrinology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Background Resistance to thyroid hormone (RTH) commonly presents with goiter, attention deficit hyperactivity disorder (ADHD), short stature and tachycardia. However, due to its variable presentation with subtle clinical features, a third of the cases are mistreated, typically as hyperthyroidism. Case presentation A 15-year-old female with ADHD and oligomenorrhea was initially diagnosed as Hashimoto's thyroiditis but found to have a rare heterozygous mutation in c803 C>G (p Ala 268 Gly) in the THRβ gene, confirming resistance to thyroid hormone. Read More

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http://dx.doi.org/10.1515/jpem-2018-0284DOI Listing
February 2019
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Trimester-specific reference ranges for thyroid hormones in pregnant women.

Medicine (Baltimore) 2019 Jan;98(4):e14245

Department of Endocrinology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou.

The aim of this study was to determine the trimester-specific reference range of thyroid function in Nanjing.A total of 805 pregnant women in the 1st, 2nd, and 3rd trimesters were recruited in the prospective, observational study during their routine antenatal clinic visit and 282 nonpregnant subjects served as controls. A questionnaire was completed by the subjects to record their personal health history, family history of thyroid disease, and consumption of estrogen or antithyroid drugs. Read More

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http://dx.doi.org/10.1097/MD.0000000000014245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358369PMC
January 2019
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[A case of periodic thyrotoxic paralysis].

Authors:
G Kisoka X Bertrand

Rev Med Liege 2019 Jan;74(1):20-22

Département des Urgences, CHR Citadelle, Liège, Belgique.

Periodic thyrotoxic paralysis (TPP) is a disease that usually affects Asian men from 20 to 50 years. It is secondary to genetic mutations of ion channels for the transport of sodium and potassium. It is characterized by recurrent and brutal bouts of paresis / flaccid paralysis, without sensory involvement, in a context of hyperthyroidism. Read More

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January 2019
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The effects of thyroid hormones on memory impairment and Alzheimer's disease.

J Cell Physiol 2019 Jan 24. Epub 2019 Jan 24.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Thyroid hormones (THs) have a wide and important range of effects within the central nervous system beginning from fetal life and continuing throughout the adult life. Thyroid disorders are one of the major causes of cognitive impairment including Alzheimer's disease (AD). Several studies in recent years have indicated an association between hypothyroidism or hyperthyroidism and AD. Read More

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http://dx.doi.org/10.1002/jcp.28198DOI Listing
January 2019
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