47,461 results match your criteria Hyperthyroidism


Thyroid state affects HO removal by rat heart mitochondria.

Arch Biochem Biophys 2018 Nov 30. Epub 2018 Nov 30.

Dipartimento di Biologia, Università di Napoli Federico II, I-80126, Napoli, Italy.

We investigated the effects of thyroid state on the mechanisms underlying rat heart mitochondrial capacity to remove HO produced by an exogenous source. The removal rates were higher in the presence of respiratory substrates independently from thyroid state and were higher in hyperthyroid than in hypothyroid preparations. The thyroid state linked changes in HO removal rates mirrored those in HO release rates showing that endogenous and exogenous HO do not compete for the removing system. Read More

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November 2018

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.

Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.

Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More

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December 2018
2 Reads

Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.

Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More

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November 2018

Efficacy of radioactive iodine treatment of graves' hyperthyroidism using a single calculated I dose.

Clin Diabetes Endocrinol 2018 28;4:20. Epub 2018 Nov 28.

1Nuclear Medicine/Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5028 USA.

Objective: To evaluate the success rate of therapeutic administration of a single calculated I activity for eliminating hyperthyroidism due to Graves' disease.

Methods And Materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated I activity of 0.2 mCi per estimated gram of thyroid tissue, adjusted for the 24-h RAIU. Read More

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November 2018

The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake.

World J Nucl Med 2018 Oct-Dec;17(4):270-274

Department of Medical Physics Radiobiology and Radiation Protection, Babol University of Medical Sciences, Babol, Iran.

Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296-444 MBq challenging dose in peripheral human lymphocyte cells. Read More

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December 2018

Evaluation of the physical and biological dosimetry methods in iodine-131-treated patients.

World J Nucl Med 2018 Oct-Dec;17(4):253-260

Department of Nuclear Medicine, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey.

The aim of the study was to compare physical and biological dosimetry methods in iodine-131 (I-131)-receiving patients. The present study comprised of 47 patients (mean age: 47.9 ± 15. Read More

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December 2018

A silent myocardial infarction with normal coronary arteries associated with Graves' disease.

Heart Lung 2018 Nov 28. Epub 2018 Nov 28.

Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Jiefang Road 1095, Wuhan 430030, Hubei, PR China. Electronic address:

Acute myocardial infarction (AMI) is a scarce but fatal complication in Graves' disease (GD). Silent myocardial infarction (MI) associated with GD has never been reported. A 37-year-old male patient was admitted due to poorly controlled hyperthyroidism and persistent fever. Read More

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November 2018

Hypoceruloplasminemia: an unusual biochemical finding in a girl with Hashimoto's thyroiditis and severe hypothyroidism.

Pediatr Med Chir 2018 Dec 5;40(2). Epub 2018 Dec 5.

Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina.

Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs. Read More

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December 2018

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism.

PLoS One 2018 4;13(12):e0208206. Epub 2018 Dec 4.

Department of Molecular Cardiology, Cleveland Clinic, Ohio, United States of America.

Background: Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.

Objective: The present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status. Read More

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December 2018
1 Read

Management of fetal goiters : 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays de Loire perinatal network.

J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.

a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.

Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More

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December 2018
3 Reads

[A toddler with a rare complication of scarlet fever].

Ned Tijdschr Geneeskd 2018 11 26;162. Epub 2018 Nov 26.

Reinier de Graaf Gasthuis, afd. Kindergeneeskunde, Delft.

Background: Haemolytic group A streptococci (GAS) are the most common bacterial cause of infection in the Netherlands. These bacteria can cause many different non-invasive infections, including scarlet fever.

Case Description: A two-year-old girl presented with fever, tachycardia, exanthema and swelling in the neck. Read More

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November 2018
1 Read

Posttraumatic stress disorder and incidence of thyroid dysfunction in women.

Psychol Med 2018 Nov 29:1-10. Epub 2018 Nov 29.

Department of Epidemiology,Harvard T.H. Chan School of Public Health,Boston, MA,USA.

Background: Abnormal thyroid function is prevalent among women and has been linked to increased risk of chronic disease. Posttraumatic stress disorder (PTSD) has been linked to thyroid dysfunction in some studies; however, the results have been inconsistent. Thus, we evaluated trauma exposure and PTSD symptoms in relation to incident thyroid dysfunction in a large longitudinal cohort of civilian women. Read More

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November 2018
1 Read

[Secondary osteoporosis. Surgical treatment for patients with secondary osteoporosis.]

Clin Calcium 2018 ;28(12):1671-1677

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

In the etiology of secondary osteoporosis, only primary hyperparathyroidism is the one to which osteoporosis itself is indicated for surgery. However, there are several diseases that may give bone a good environment by surgical treatment for primary diseases such as hyperthyroidism or Cushing's syndrome, and secondary osteoporosis may improve. It is important to properly conduct differential diagnosis and to discuss and determine surgical indication. Read More

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January 2018
1 Read

[Secondary osteoporosis. Hyperthyroidism.]

Authors:
Akihiro Yasoda

Clin Calcium 2018 ;28(12):1619-1625

Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Thyrotoxicosis, commonly seen in a condition with Graves' disease, causes increased bone absorption and results in osteoporosis with increased bone turnover. The osteoporotic state is dominant in cortical bones with slight impairment of calcium-homeostasis, although the precise mechanism is still elusive. It ought to be recovered in accordance with the amelioration of thyroid hormone status, but past history of thyrotoxicosis might cause bone fragility, especially in post-menopausal or senile patients. Read More

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January 2018

Prevalence of autoimmune thyroid diseases among the Turner Syndrome patients: meta-analysis of cross sectional studies.

BMC Res Notes 2018 Nov 29;11(1):842. Epub 2018 Nov 29.

Faculty of Medicine, University of Khartoum, Qasr Street, P.O. Box 11111, Khartoum, Sudan.

Objective: This meta-analysis was done to estimate the prevalence of autoimmune thyroid diseases (ATDs) in Turner Syndrome patients, and to determine the clinical status of thyroid autoimmune diseases that occur frequently in association with Turner Syndrome.

Results: A total of 18 studies were included in the meta-analysis. The pooled overall prevalence of autoimmune thyroid diseases in Turner Syndrome patients was 38. Read More

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November 2018

Rapid Relief: Thyroidectomy is a Quicker Cure than Radioactive Iodine Ablation (RAI) in Patients with Hyperthyroidism.

World J Surg 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., E6.104B, Dallas, TX, 75390-9092, USA.

Background: Time to hormonal control after definitive management of hyperthyroidism is unknown but may influence patient and physician decision making when choosing between treatment options. The hypothesis is that the euthyroid state is achieved faster after thyroidectomy than RAI ablation.

Methods: A retrospective review of all patients undergoing definitive therapy for hyperthyroidism was performed. Read More

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November 2018

[McCune-Albright syndrome with hyperthyroidism: report of one case and review of literature].

Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):445-448

Department of Stomatology, Central Hospital of Xuzhou City. Xuzhou 221009, Jiangsu Province, China.

McCune-Albright Syndrome(MAS) is a rare disease characterized by triad of polyostotic fibrous dysplasia of bone(FD), precocious puberty, and café-au-lait skin pigmentation. This paper reported a case of McCune-Albright syndrome with hyperthyroidism, and discussed the pathogenesis, clinical manifestations, diagnosis and treatment of MAS. Read More

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August 2018
2 Reads

[A special case of hyperthyroidism with liver injury in Graves' disease].

Authors:
R R Zhao Y D Deng

Zhonghua Gan Zang Bing Za Zhi 2018 Sep;26(9):698-699

Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730030, China.

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September 2018
1 Read

Subclinical hyperthyroidism in the course of autonomous nodules - clinical evaluation.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.

Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More

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November 2018
3 Reads

Thyroid hormones mediate metabolic rate and oxidative, anti-oxidative balance at different temperatures in Mongolian gerbils (Meriones unguiculatus).

Comp Biochem Physiol C Toxicol Pharmacol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Oxidative damage is a potential physiological cost of thermoregulation during seasonal adjustments to air temperature (T) in small mammals. Here, we hypothesized that T affects serum thyroid hormone levels and these hormones can mediate the changes in metabolic rate and oxidative damage. Mongolian gerbils (Meriones unguiculatus) were acclimated at different Ts (5 °C, 23 °C and 37 °C) for 3 weeks. Read More

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November 2018
6 Reads

Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management.

Case Rep Endocrinol 2018 24;2018:3268010. Epub 2018 Oct 24.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

The coexistence of thyroid functioning nodules and Graves' disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2. Read More

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October 2018
5 Reads

Potentiating effect of rifampicin on methimazole induced hepatotoxicity in mice.

Pak J Pharm Sci 2018 Nov;31(6):2373-2377

Combined Military Hospital, Okara Cantt, Okara, Pakistan.

Methimazole (MMI) is a widely used drug for hyperthyroidism. However, its clinical use is associated with hepatotoxicity. Though the precise mechanism of hepatic damage is still far from clear, role of metabolic activation and reactive metabolites have been implicated. Read More

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November 2018
1 Read

Graves' disease in clinical perspective.

Front Biosci (Landmark Ed) 2019 01 1;24:35-47. Epub 2019 Jan 1.

Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Graves' disease (GD) is the most common cause for hyperthyroidism in iodine-replete areas. The disease is caused by the appearance of stimulating TSH receptor autoantibodies (TRAb) leading to hyperthyroidism. Blocking and neutral TRAb have, however, also been described. Read More

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January 2019
2 Reads

Evaluation of redox profiles in exogenous subclinical hyperthyroidism at two different levels of TSH suppression.

Arch Endocrinol Metab 2018 Oct;62(5):545-551

Departamento de Endocrinologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0. Read More

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October 2018
1 Read

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women.

Sex Med Rev 2018 Nov 17. Epub 2018 Nov 17.

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Introduction: Sexual dysfunction affects many people, with 33‒60% of women reporting sexual dysfunction and 8‒52% of men with erectile dysfunction or premature ejaculation. In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest.

Aim: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. Read More

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November 2018
2 Reads

Severe cholestatic jaundice associated with Graves' disease.

Clin Case Rep 2018 Nov 12;6(11):2240-2245. Epub 2018 Oct 12.

Division of General and Geriatric Medicine, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas.

We describe a rare case of Graves' disease presenting with atrial fibrillation and severe cholestasis. An extensive evaluation for hepatobiliary causes of cholestasis, including hepatic biopsy, was entirely negative. He was successfully treated with methimazole and eventual thyroidectomy. Read More

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November 2018
2 Reads

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives.

Clin Case Rep 2018 Nov 2;6(11):2178-2184. Epub 2018 Oct 2.

Internal Medicine Department, Faculty of Medicine Alexandria University Alexandria Egypt.

The autoimmune polyglandular syndrome is a sequential chain of autoimmune events. Whenever diagnosed, the clinician's target should be induction of remission and if possible hindering its progression especially if associated with refractory vitiligo, resistant Grave's, or unexplained hyperglycemia in T1DM. Azathioprine could be used for induction of remission in autoimmune polyglandular syndrome type three especially with vitiligo and autoimmune thyroiditis. Read More

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November 2018
8 Reads

[Difficulties in managing Graves' disease in children: about a case].

Pan Afr Med J 2018 27;30:183. Epub 2018 Jun 27.

Service d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU Mohamed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Adequate management of Graves' disease in children is an area of controversy in pediatric endocrinology, while optimal duration of medical treatment inducing remission in disease as well as indications for therapeutic alternatives still needs to be determined. We report the case of a 11-year old female child with no particular past medical history., presenting with progressive weight loss associated with diarrhea. Read More

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June 2018
2 Reads

Unusual invasion of primary pulmonary adenocarcinoma in a cat.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918810897. Epub 2018 Nov 8.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA.

Case Summary: An 11-year-old female spayed domestic shorthair cat was referred to the Foster Hospital for Small Animals, USA for suspected dysautonomia based on weight loss, vomiting and referral radiographs that showed severe dilation of the esophagus, stomach and entire gastrointestinal tract. After recheck radiographs revealed a decrease in gas compared with the referral images, persistently reduced gastrointestinal motility was deemed less likely; however, cardiomegaly and a soft tissue opacity overlying the esophagus were noted. Echocardiogram identified a pulmonary mass either impinging on or invading the local organs. Read More

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November 2018
2 Reads

Screening of thyroid function and autoantibodies in patients with alopecia areata: A systematic review and meta-analysis.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

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November 2018
4 Reads

Differences in Diagnostic Criteria Mask the True Prevalence of Thyroid Disease in Pregnancy - A Systematic Review and Meta-Analysis.

Thyroid 2018 Nov 16. Epub 2018 Nov 16.

University of Illinois College of Medicine at Rockford, Department of Medicine , 1601 Parkview Avenue , Rockford, Illinois, United States , 61107-1897 ;

Background: The reported prevalence of thyroid disease in pregnancy varies widely through the published literature. These discrepancies are due to differences in criteria for euthyroidism, nationality, iodine status and gestational age at screening. As a result, there does not currently exist an accepted rate of prevalence for the various thyroid diseases in pregnancy. Read More

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November 2018
1 Read

An evaluation score of the difficulty of thyroidectomy considering operating time and preservation of recurrent laryngeal nerve.

Updates Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

The purpose of this study was to edit a renovated thyroidectomy difficulty scale (rTDS) in order to identify underlying thyroid diseases with a longer operative time and higher technical difficulty, also considering preservation of recurrent laryngeal nerve. We developed a renovated scale with a maximum score of 20 points by creating a form in which five variables were considered: vascularity, friability, mobility/fibrosis, gland size and difficulty in preservation of the recurrent laryngeal nerve. Two surgeons separately evaluated each of these. Read More

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November 2018
5 Reads

Heart rate variability in hyperthyroidism on sub Saharan African patients: a case-control study.

BMC Res Notes 2018 Nov 15;11(1):814. Epub 2018 Nov 15.

National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.

Objective: We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. Read More

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November 2018
5 Reads

Periodic paralysis with normokalemia in a patient with hyperthyroidism: A case report.

Medicine (Baltimore) 2018 Nov;97(46):e13256

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Thyrotoxic periodic paralysis is characterized by a sudden onset of hypokalemia and paralysis. This condition mainly affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle without typical symptoms such as palpitations, tremors, anxiety, and weight loss; this causes a difficulty in early diagnosis. Read More

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November 2018
8 Reads

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan.

Medicine (Baltimore) 2018 Nov;97(46):e13254

Department of Internal Medicine, National Taiwan University Hospital, and National Taiwan University College of Medicine.

Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. Read More

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November 2018
4 Reads

Incidence of neonatal hyperthyroidism among newborns of Graves' disease patients treated with radioiodine therapy.

Thyroid 2018 Nov 14. Epub 2018 Nov 14.

Ito Hospital, Surgery, Tokyo, Japan ;

Background: The serum TSH receptor antibody (TRAb) titers of Graves' disease (GD) patients is known to increase after radioiodine (RAI) therapy and remain high for years. The incidence of neonatal hyperthyroidism (NH) among the newborns born to mothers with GD who conceived after RAI therapy have not been reported in the past. Objective; To investigate the incidence of NH among the newborns born to mothers who conceived within 2 years after RAI therapy, and to identify predictors of NH. Read More

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November 2018
3 Reads

Controversies in the pharmacological treatment of Graves' disease in children.

Expert Rev Clin Pharmacol 2018 Nov 15;11(11):1113-1121. Epub 2018 Nov 15.

a UOC Pediatria, Department of Human Pathology of Adulthood and Childhood , University of Messina , Messina , Italy.

Introduction: Graves' disease (GD) is a disorder, in which auto-immunity against the thyroid- stimulating hormone (TSH) receptor is the pivotal pathogenetic element. This disease may have different clinical manifestations, the most common being thyrotoxicosis. Treatment of this condition differs according to its etiology, but there is currently no evidence-based therapeutic strategy which is universally adopted in all countries. Read More

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November 2018
1 Read

A Rare Case of Heterozygous Gain of Function Thyrotropin Receptor Mutation Associated with Development of Thyroid Follicular Carcinoma.

Case Rep Genet 2018 17;2018:1381730. Epub 2018 Oct 17.

Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Activating mutations in thyrotropin receptor () have been previously described in the context of nonautoimmune hyperthyroidism and thyroid adenomas. We describe, for the first time, a mutation in contributing to follicular thyroid carcinoma (FTC) in an adolescent. A 12-year-old girl presented with a right-sided neck swelling, increasing in size over the previous four weeks. Read More

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October 2018
4 Reads

The effect of total thyroidectomy on the recovery of bone mineral density in subjects with hyperthyroidism.

Surgery 2018 Nov 8. Epub 2018 Nov 8.

Department of Radiology, SKS Hospital, Salem, India.

Background: Although hyperthyroidism is associated with high turnover osteopenia and its recovery after treatment, the extent of recovery with different forms of therapy remains controversial. This prospective study evaluated the bone mineral density in thyrotoxic subjects undergoing total thyroidectomy and I radioactive iodine therapy.

Methods: Newly diagnosed subjects with hyperthyroidism undergoing total thyroidectomy (group 1; n = 127) and I radioactive iodine therapy (group 2; n = 30) were evaluated for bone mineral density by dual energy x-ray absorptiometry at the time of diagnosis (point A), on achieving euthyroidism with antithyroid drugs (point B), and 6 months after definitive treatment (point C). Read More

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November 2018
4 Reads

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents.

Molecules 2018 Nov 8;23(11). Epub 2018 Nov 8.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.

Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel. Read More

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November 2018
2 Reads
2.416 Impact Factor

Acute Thyroid Storm Following Thymectomy: A Surprising Result of Undiagnosed Graves' Disease.

Cureus 2018 Aug 31;10(8):e3239. Epub 2018 Aug 31.

Surgery, University of Texas Medical Branch, Galveston, USA.

Postoperative thyroid storm represents a diagnostic dilemma in patients with overlooked hyperthyroid state undergoing a nonthyroid surgery. We report a 30-year-old female with a history of mixed connective tissue disease who presented with an anterior mediastinal mass and underwent a thoracoscopic resection of the mass. On postoperative day 1, she had an acute change in mental status with fever, tachycardia and hypercapnic respiratory failure requiring intubation and mechanical ventilation. Read More

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August 2018
4 Reads

Resistant Thyrotoxicosis due to Graves' Disease in Pregnancy: Case Report and Review of the Literature.

Cureus 2018 Aug 30;10(8):e3232. Epub 2018 Aug 30.

Department of Endocrinology, Diabetes and Metabolism, E. Venizelou Hospital, Athens, GRC.

The effective management of Graves' disease (GD) during pregnancy is crucial for maternal and neonatal well-being. Conventional treatment of GD during pregnancy includes antithyroid drugs (ATDs) and surgery, ideally during the second trimester. We report a 27-year-old woman with GD and we present the course of GD during her three consecutive pregnancies. Read More

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August 2018
4 Reads

Thyroid Screening in Early Pregnancy: Pros and Cons.

Front Endocrinol (Lausanne) 2018 25;9:626. Epub 2018 Oct 25.

Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom.

Universal thyroid screening in pregnancy is a key debate in thyroidology and obstetrics. It is well-established that thyroid hormones are essential for maintaining pregnancy and optimal fetal development. Thyroid dysfunction is common in women of child-bearing age and also results in substantial adverse obstetric and child neurodevelopmental outcomes. Read More

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October 2018
5 Reads

Complicated Gitelman syndrome and autoimmune thyroid disease: a case report with a new homozygous mutation in the SLC12A3 gene and literature review.

BMC Endocr Disord 2018 Nov 8;18(1):82. Epub 2018 Nov 8.

The Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Background: Gitelman syndrome (GS) is an inherited autosomal recessive renal tubular disorder characterized by low levels of potassium and magnesium in the blood, decreased excretion of calcium in the urine, and elevated blood pH. GS is caused by an inactivating mutation in the SLC12A3 gene, which is located on the long arm of chromosome 16 (16q13) and encodes a thiazide-sensitive sodium chloride cotransporter (NCCT).

Case Presentation: A 45-year-old man with Graves' disease complicated by paroxysmal limb paralysis had a diagnosis of thyrotoxic periodic paralysis for 12 years. Read More

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November 2018
1 Read

Clinical efficacy and safety of traditional Chinese patent medicine for hyperthyroid heart disease: study protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Nov;97(45):e13076

Guang'anmen Hospital of China Academy of Chinese Medical Sciences.

Background: Hyperthyroid heart disease (HHD), one of the most common complications of hyperthyroidism, is a serious public health problem due to the direct toxic or indirect effects of excessive thyroid hormone on the heart, resulting in high mortality and increasing health care costs. Traditional Chinese patent medicines (TCPMs), developed by combining modernized pharmaceutical technologies with ancient TCM theories, have been widely used in the treatment of HHD. However, the safety and efficacy of TCPMs used in patients with HHD has been uncertain and there has been no standard clinical trial published to confirm this. Read More

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November 2018
6 Reads

Autoimmune Thyroid Disease in Islet Transplant Recipients Discontinuing Immunosuppression Late After Lymphodepletion.

J Clin Endocrinol Metab 2018 Nov 5. Epub 2018 Nov 5.

Division of Endocrinology, University of Alberta, Edmonton, AB.

Context: Clinical islet transplantation (CIT) is an innovative strategy to treat highly selected individuals with type 1 diabetes mellitus (T1DM). Lymphodepletion with alemtuzumab or thymoglobulin is often used for induction therapy in CIT. Alemtuzumab was recently licensed as a treatment for relapsing remitting multiple sclerosis (RRMS). Read More

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November 2018
5 Reads

Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management.

Pituitary 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurosurgery, University Hospital of Lausanne, Lausanne, Switzerland.

Purpose: TSH-secreting pituitary adenomas are rare pituitary tumors. An efficient treatment is essential to limit the mortality and morbidity in untreated patients. The aim of this study is to summarize the evidence about the postoperative outcomes and management of this rare pathology. Read More

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November 2018
6 Reads
2.220 Impact Factor

Association of benign thyroid diseases with thyroid cancer risk: a meta-analysis of prospective observational studies.

J Endocrinol Invest 2018 Nov 1. Epub 2018 Nov 1.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.

Purpose: Evidence showed that benign thyroid disease was one of the risk factors for thyroid cancer. However, the results of some studies were inconsistent and were previously meta-analyses of case-control studies. Therefore, we performed a meta-analysis of prospective studies to investigate the relationship between benign thyroid diseases and thyroid cancer risk. Read More

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November 2018
4 Reads

Metabolomics for Prediction of Relapse in Graves' Disease: Observational Pilot Study.

Front Endocrinol (Lausanne) 2018 17;9:623. Epub 2018 Oct 17.

Division of Endocrinology, Diabetes and Metabolism, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.

There is a lack of biochemical markers for early prediction of relapse in patients with Graves' disease [GD], which may help to direct treatment decisions. We assessed the prognostic ability of a high-throughput proton NMR metabolomic profile to predict relapse in a well characterized cohort of GD patients. Observational study investigating patients presenting with GD at a Swiss hospital endocrine referral center and an associated endocrine outpatient clinic. Read More

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October 2018
4 Reads