47,846 results match your criteria Hyperthyroidism


BASELINE TSH LEVEL IS ASSOCIATED WITH RISK OF ANTI PD-1 INDUCED THYROID DYSFUNCTION.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Department of Endocrinology and Metabolism, Division of Medicine, Hadassah-Hebrew University Hospital, Jerusalem Israel.

To characterize anti-programmed cell death 1 (PD-1) induced thyroid immune related adverse events (irAEs) in metastatic melanoma patients treated at our institution and to identify risk factors associated with their development. We reviewed the files of 154 patients with metastatic melanoma treated with PD-1 inhibitors at a single institution from November 1, 2011 to February 28, 2017. The association of thyroid irAEs within 120 days post-treatment initiation with age, gender, melanoma characteristics, treatment protocol, and baseline TSH was examined. Read More

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http://dx.doi.org/10.4158/EP-2018-0472DOI Listing

Medications that Cause Fetal Anomalies and Possible Prevention Strategies.

Clin Perinatol 2019 Jun 28;46(2):203-213. Epub 2019 Mar 28.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, Mail Code #0828, La Jolla, CA 92039, USA. Electronic address:

Many conditions that require frequent medication use are common during pregnancy. The purpose of this article is to list some of the most common of these disorders and to discuss the risk to the developing fetus of the medications used most frequently to treat them. Included are drugs used for the treatment of asthma, nausea and vomiting, hyperthyroidism, pain and fever, and depression during pregnancy. Read More

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http://dx.doi.org/10.1016/j.clp.2019.02.003DOI Listing

[An unusual cause of jaundice].

Pan Afr Med J 2018 2;31:72. Epub 2018 Oct 2.

Service d'Hépato-Gastroentérologie de l'Hôpital Aritide Le Dantec, Dakar, Sénégal.

Hepatic impairment is common during hyperthyroidism. It is most often asymptomatic. Hyperthyroidism revealed by jaundice has been rarely described in the literature. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.72.16967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457717PMC
October 2018

Letter to the Editor regarding the article "Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach".

Thyroid 2019 Apr 22. Epub 2019 Apr 22.

Universtity of Patras Medical School , Rion , Patras, Greece , 26500 ;

We have read with great interest the recently published paper by Livadas et al in which, authors have found that 60.8% of patients on long-term levothyroxine (LT4) replacement therapy, in whom the diagnosis of hypothyroidism is not well established, remained euthyroid 6-8 weeks post discontinuation of LT4. We have concerns about the short period of re-evaluation of these patients. Read More

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http://dx.doi.org/10.1089/thy.2018.0765DOI Listing

The association between clinical and laboratory parameters in thyroid disease and nonthyroidal illness in young women.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2950-2959

Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.

Objective: Evidence from epidemiological and clinical studies strongly suggest that young women in the preconception period are a group at risk for thyroid disorders which may lead to further aggravation of pre-existing chronic thyroid disease and complications during pregnancy.

Materials And Methods: This paper is a literature review focusing on articles published in English between 2014-2017 searched in Medline database using terms 'young women', 'subclinical hyperthyroidism', 'subclinical hypothyroidism', 'nonthyroidal illness syndrome', 'obesity', 'depression'.

Conclusions: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17575DOI Listing

Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-κB at ED 20.

Authors:
Ahmed R G

Toxicol Res (Camb) 2019 Mar 11;8(2):196-205. Epub 2018 Dec 11.

Division of Anatomy and Embryology , Zoology Department , Faculty of Science , Beni-Suef University , Beni-Suef , Egypt . Email: ; Email:

The objective of this examination was to explore the impact of gestational caffeine (1,3,7-trimethylxanthine) exposure on the maternofetal thyroid axis and fetal thyroid-cytokine communications during gestation. Pregnant rats () were intraperitoneally administered caffeine (120 or 150 mg kg) from gestation day (GD) 1 to 20. Both doses of caffeine resulted in maternal hyperthyroidism, whereas the elevation in the concentration of serum free triiodothyronine (FT3) and free thyroxine (FT4) was related to a depletion in the level of TSH at GD 20. Read More

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http://xlink.rsc.org/?DOI=C8TX00227D
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http://dx.doi.org/10.1039/c8tx00227dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415617PMC
March 2019
1 Read

Anatomical assessment of the adult skeleton of zebrafish reared under different thyroid hormone profiles.

Anat Rec (Hoboken) 2019 Apr 15. Epub 2019 Apr 15.

Department of Biological Sciences, The George Washington University, Science and Engineering Hall, 800 22nd Street NW, Suite 6000, Washington, DC 20052.

Thyroid hormone (TH) directs the growth and maintenance of tissues throughout the body during development and into adulthood, and plays a particularly important role in proper ossification and homeostasis of the skeleton. To better understand the roles of TH in the skeletogenesis of a vertebrate model, and to define areas of the skeleton that are particularly sensitive to developmental TH, we examined the effects of hypo- and hyperthyroidism on skeletal development in zebrafish. Performing a bone-by-bone anatomical assessment on the entire skeleton of adult fish, we found that TH is required for proper ossification, growth, morphogenesis, and fusion of numerous bones. Read More

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http://dx.doi.org/10.1002/ar.24139DOI Listing

Diffusely Increased F-FDG Uptake in the Thyroid Gland and Risk of Thyroid Dysfunction: A Cohort Study.

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea.

The impact of incidentally identified diffuse thyroid FDG uptake on F-FDG PET/CT scan on the incidence of thyroid dysfunction remains unclear. We examined the association of diffuse thyroid FDG uptake with the development of thyroid dysfunction. This cohort study involved 39,098 Korean adults who were free of malignancy and thyroid disease at baseline and underwent regular health checkup examinations including an F-FDG whole body PET/CT scan, thyroid-stimulating hormone and free thyroxine. Read More

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http://dx.doi.org/10.3390/jcm8040443DOI Listing
April 2019
2 Reads

Thyroxine-Induced Preradial Myxedema.

Indian Dermatol Online J 2019 Mar-Apr;10(2):162-164

Department of Skin and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India.

Localized myxedema is most commonly described in patients with hyperthyroidism, especially Graves' disease. Although pretibial myxedema generally appears as indurated plaques on the shins, it has also been rarely reported in other areas such as the face, shoulders, arms, and abdomen. We report a rare case of preradial myxedema in a hyperthyroid patient who was taking thyroxine post thyroidectomy for goiter. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_161_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434759PMC
April 2019
2 Reads

The potential influence of hyperthyroidism on circulating adipokines chemerin, visfatin, and omentin.

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):44-47

Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Objectives: The aim of this study was to investigate the potential influence of hyperthyroidism on serum chemerin, visfatin, and omentin concentrations. The relationship between these adipokines and thyroid profile values was also investigated.

Methods: A total of 140 female Saudi participants aged 20-45 years were recruited and divided into two groups, the euthyroid control group ( = 70) and the hyperthyroidism group ( = 70). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436451PMC

Correlation of vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in serum and thyroid nodules with histopathological and radiological variables.

J Lab Physicians 2019 Jan-Mar;11(1):51-57

Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.

Background/aim: Vascular endothelial growth factor (VEGF) is a major cytokine in angiogenesis and has a role on aggressivity of various tumors. The expression of VEGF has been shown to increase in differential thyroid cancer. The aim of the study was to evaluate serum and intranodular VEGF (nVEGF) and VEGF receptor-1 (VEGFR-1) levels in patients with thyroid nodules and their relevance to ultrasonographic and pathological results. Read More

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http://dx.doi.org/10.4103/JLP.JLP_41_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437829PMC

Iatrogenic hyperthyroidism can be a triggering factor for takotsubo cardiomyopathy.

Med Clin (Barc) 2019 Apr 8. Epub 2019 Apr 8.

Departamento Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.medcli.2019.02.014DOI Listing

Thyroid hemiagenesis is combined with a variety of thyroid disorders.

Nuklearmedizin 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital of Cologne.

Aim: Thyroid hemiagenesis (TH) is a rare congenital anomaly in which one thyroid lobe fails to develop. We describe our experience with at least 13 patients presenting with TH at our department.

Methods: We retrospectively analysed patients with TH, who had been referred primarily to our clinic between 2004 and 2010. Read More

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http://dx.doi.org/10.1055/a-0830-4425DOI Listing
April 2019
1 Read

Three consecutive pregnancies in a patient with chronic autoimmune thyroid disease associated with hypothyroidism and extremely high levels of anti-TSH receptor antibodies.

Thyroid 2019 Apr 11. Epub 2019 Apr 11.

Centre Hospitalier Universitaire de Reims, 26992, Service d'Endocrinologie - Diabète - Nutrition, Reims, Champagne-Ardenne, France.

Background: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications.

Patient Findings: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0098
Publisher Site
http://dx.doi.org/10.1089/thy.2018.0098DOI Listing
April 2019
3 Reads

[Efficacy of 99mTc-DTPA orbital SPECT/CT on the evaluation of lacrimal gland inflammation in patients with 
thyroid associated ophthalmopathy].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):322-328

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the values of orbital single photon emission computed tomography/computerized tomography (SPECT/CT) with 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) on the evaluation of lacrimal gland inflammation in patients with thyroid associated ophthalmopathy (TAO).
 Methods: A total of 58 TAO patients were retrospectively recruited for this study, all of whom were categorized into all active group and all inactive group based on the clinical active score (CAS). Another 12 patients with the negative images on SPECT/CT served as a normal control group (NC). Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.03.014DOI Listing
March 2019
5 Reads

Acute psychosis in patients with subclinical hyperthyroidism.

Psychiatry Clin Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.

We report two cases of subclinical hyperthyroidism (SCHT) in patients with an acute psychotic episode with mania-like symptoms. Patient A was a 20-year-old woman with no previous medical history, and never experienced affective and psychotic symptoms. She also had no family history of mental illness. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pcn.12847
Publisher Site
http://dx.doi.org/10.1111/pcn.12847DOI Listing
April 2019
8 Reads

Current Practice of Surgery for Benign Goitre-An Analysis of the Prospective DGAV StuDoQ|Thyroid Registry.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Department of Visceral-, Vascular and Endocrine Surgery, University Medical Centre Halle, 06120 Halle, Germany.

Background: To evaluate the current indications, resection strategies and short-term outcomes of surgery for benign goitre in a country with endemic goitre.

Methods: Data of patients who underwent surgery for benign goitre were retrieved from the prospective StuDoQ/Thyroid registry and retrospectively analysed regarding the patient's demographics, indications for surgery, surgical procedures, histology, and perioperative outcomes.

Results: In a 15-month period, 12,888 patients from 83 departments underwent thyroid resections for benign conditions. Read More

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http://dx.doi.org/10.3390/jcm8040477DOI Listing
April 2019
1 Read

Thyrotoxic periodic paralysis with ventricular tachycardia.

J Electrocardiol 2019 Apr 4;54:93-95. Epub 2019 Apr 4.

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

A 47-year-old man presented to our emergency department (ED) with limbs weakness for 2 h. His heart rate was 127 beats per minute and blood pressure was 95/49 mm Hg. He found weakness of limbs after 4-h sleep. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.04.001DOI Listing
April 2019
2 Reads

DYNAMICS OF INDICES OF OXIDATIVE STRESS IN PATIENTS WITH THYROID GLAND SURGERY DEPENDING ON ITS FUNCTIONAL ACTIVITY.

Georgian Med News 2019 Feb(287):87-90

Kharkov National Medical University; Kharkov Medical Academy of Postgraduate Education, Ukraine.

Hormonal dysfunction of the thyroid gland causes disorder of all kinds of metabolism. Both hypothyroidism, and hyperthyroidism are the causes of imbalance in prooxidant-antioxidant system with the development of pathological process named "oxidative stress". Objective - study of oxidative stress in patients who underwent thyroid gland operation depending on its functional activity and the presence of autoimmune thyroiditis. Read More

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February 2019
2 Reads

Transient T3 toxicosis associated with Hashimoto's disease.

Proc (Bayl Univ Med Cent) 2019 Jan 19;32(1):80-81. Epub 2018 Oct 19.

Texas Tech University Health Sciences Center, Clinical Research Institute and Department of Internal MedicineLubbockTexas.

In its early course, Hashimoto's disease may present as thyrotoxicosis (Hashitoxicosis). This usually manifests as elevated free T4 and suppressed thyroid-stimulating hormone (TSH). We report the unusual occurrence of an elevated T3 level in a patient with Hashimoto's disease. Read More

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http://dx.doi.org/10.1080/08998280.2018.1503480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442890PMC
January 2019
1 Read

A review of the propriety of thyroid ultrasound referrals and their follow-up burden.

Endocrine 2019 Apr 6. Epub 2019 Apr 6.

Department of Endocrinology, Connolly Hospital, Blanchardstown, Co Dublin, Ireland.

Purpose: The overdiagnosis of thyroid nodules and indolent thyroid cancers represents an increasing burden on health services, with thyroid ultrasound (US) imaging often representing the initial entry point into the thyroid nodule diagnostic pathway. The aim of this study was to retrospectively review thyroid US referrals to a single Irish hospital to determine if the stated indications for imaging had been appropriate, to review the results of the scans, and to assess the follow-up required in each case.

Methods: Patient demographics, scan indications, results, and outcomes were retrospectively reviewed for all patients undergoing thyroid ultrasound from 2012 to 2016. Read More

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http://dx.doi.org/10.1007/s12020-019-01920-1DOI Listing
April 2019
3 Reads

Isolated leg tremor in a middle-aged woman: an unusual presenting symptom of Graves' disease.

Acta Neurol Belg 2019 Apr 6. Epub 2019 Apr 6.

Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, Republic of Korea.

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http://dx.doi.org/10.1007/s13760-019-01127-1DOI Listing
April 2019
1 Read

Hypothyroidism to hyperthyroidism: an immunological pendulum swing from two extreme poles - a case series.

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Department of Endocrinology, Albany Medical Center Hospital, Albany, New York, USA.

We report two women who were diagnosed with hypothyroidism due to what was thought to be Hashimoto's thyroiditis 18 and 16 years ago, respectively. They had been euthyroid on stable doses of levothyroxine for many years, and they presented to our clinic with clinically and biochemically overt hyperthyroidism that persisted even after stopping levothyroxine. Immunological and imaging workups were consistent with Graves' disease. Read More

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http://dx.doi.org/10.1136/bcr-2018-227445DOI Listing
April 2019
3 Reads

Long-term outcomes and risk factors of thyroid dysfunction during pegylated interferon and ribavirin treatment in patients with chronic hepatitis C infection in Taiwan.

BMC Endocr Disord 2019 Apr 5;19(1):36. Epub 2019 Apr 5.

Department of Occupational Medicine, Tainan Municipal Hospital (managed by Show Chwan Medical Care Corporation), Tainan, Taiwan. No. 670, Chongde Road, East District, Tainan, Taiwan.

Background: This study aimed to investigate the occurrence and risk factors of thyroid dysfunction (TD) in patients with chronic hepatitis C (CHC) infection in Taiwan.

Methods: The data in this study were obtained from the Taiwan National Health Insurance Research (Taiwan NHIR) database between 2001 and 2013. CHC patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) were enrolled as case patients, and nontreated CHC patients were enrolled as controls and were matched at a control:case ratio of 3:1 by index date, age (± 3 years), and sex. Read More

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http://dx.doi.org/10.1186/s12902-019-0362-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451221PMC
April 2019
2 Reads

[Iodinated contrast medium in patients with thyroid disorders].

Radiologe 2019 Apr 4. Epub 2019 Apr 4.

Praxis für Endokrinologie und Nuklearmedizin, Brückenstraße 21, 69210, Heidelberg, Deutschland.

Background: Adequate intake of iodine is essential for normal thyroid function. However, sudden exposure to high amounts of iodine may cause thyroid dysfunction.

Aim: The aims of this paper are to summarize the literature on the effects of iodinated contrast medium (CM) on thyroid function, the risk to develop CM-induced hyper- and hypothyroidism, and to describe procedures for clinical practice regarding diagnosis, prevention, and treatment of CM-induced hyperthyroidism. Read More

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http://dx.doi.org/10.1007/s00117-019-0520-yDOI Listing
April 2019
2 Reads

Normalization of thyroid function tests among thyrotoxicosis patients attending a University Hospital in North-West Ethiopia.

Thyroid Res 2019 23;12. Epub 2019 Mar 23.

Department of Clinical Pharmacy, Lecturer and Preceptor of Clinical Pharmacy, UOG University of Gondar College of Medicine and Health Sciences, School of Pharmacy, Gondar, Ethiopia.

Background: Thyrotoxicosis is a clinical state that results from inappropriately high thyroid hormone action in tissues. Although it is one of the common endocrine disorders, there is scarcity of data on the management of thyrotoxicosis in Africa, particularly in Ethiopia. The aim of this study was to investigate treatment outcomes and determinants of treatment outcomes among hyperthyroid patients on antithyroid drugs attending a teaching hospital in Ethiopia. Read More

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http://dx.doi.org/10.1186/s13044-019-0064-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431050PMC
March 2019
2 Reads

Subclinical thyroid dysfunction is associated with adverse prognosis in heart failure patients with reduced ejection fraction.

BMC Cardiovasc Disord 2019 Apr 4;19(1):83. Epub 2019 Apr 4.

Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, People's Republic of China.

Background: Subclinical thyroid dysfunction whose typical patterns include subclinical hypothyroidism and subclinical hyperthyroidism, has been indicated to be associated with an increased risk of heart failure (HF). However, the relationship between subclinical thyroid dysfunction and the clinical outcomes of HF patients is uncertain. This meta-analysis was conducted to assess the association between subclinical thyroid dysfunction and the clinical outcomes of HF patients. Read More

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http://dx.doi.org/10.1186/s12872-019-1055-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450005PMC
April 2019
1 Read

Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(14):e15007

Spinal tumor center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Read More

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http://dx.doi.org/10.1097/MD.0000000000015007DOI Listing
April 2019
3 Reads

Switching Between β-Blockers: An Empiric Tool for the Cardiovascular Practitioner.

Can J Cardiol 2019 Apr 31;35(4):539-543. Epub 2019 Jan 31.

Division of Cardiology, St Paul's Hospital and Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

β-Blockers are a cornerstone of therapy for cardiovascular disease, but their clinical benefits are not consistent across the class and specific agents are preferred for certain indications. Further, when prescribed, a patient's clinical status might change, requiring the cardiologist to switch to an alternate agent. Examples of such scenarios include the development or a worsening of chronic noncardiac diseases (eg, hyperthyroidism, renal failure), new cardiac-related disease (eg, heart failure, atrial fibrillation), or practical/safety issues (eg, pregnancy, cost, side effects). Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.013DOI Listing
April 2019
3 Reads

Effects of hyperthyroidism in the development of the appendicular skeleton and muscles of zebrafish, with notes on evolutionary developmental pathology (Evo-Devo-Path).

Sci Rep 2019 Apr 1;9(1):5413. Epub 2019 Apr 1.

Department of Anatomy, Howard University College of Medicine, 520W Street NW, 20059, Washington, DC, USA.

The hypothalamus-pituitary-thyroid (HPT) axis plays a crucial role in the metabolism, homeostasis, somatic growth and development of teleostean fishes. Thyroid hormones regulate essential biological functions such as growth and development, regulation of stress, energy expenditure, tissue compound, and psychological processes. Teleost thyroid follicles produce the same thyroid hormones as in other vertebrates: thyroxin (T4) and triiodothyronine (T3), making the zebrafish a very useful model to study hypo- and hyperthyroidism in other vertebrate taxa, including humans. Read More

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http://dx.doi.org/10.1038/s41598-019-41912-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443675PMC
April 2019
2 Reads

Risk of benign paroxysmal positional vertigo in patients with depressive disorders: a nationwide population-based cohort study.

BMJ Open 2019 Mar 30;9(3):e026936. Epub 2019 Mar 30.

Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Objective: The association between depression and benign paroxysmal positional vertigo (BPPV) remains debated. This study aimed to investigate the risk of BPPV in patients with depressive disorders.

Design: Longitudinal nationwide cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026936DOI Listing
March 2019
2 Reads

Rare and Low-Frequency Variants in RNF213 Confer Susceptibility to Moyamoya Syndrome Associated with Hyperthyroidism.

World Neurosurg 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Background: Moyamoya syndrome (MMS), distinguished from definite moyamoya disease (MMD), is characterized by moyamoya vasculopathy thought to develop secondary to underlying conditions (e.g., hyperthyroidism). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.172DOI Listing
March 2019
1 Read

Thyrotoxicosis: Diagnosis and Management.

Mayo Clin Proc 2019 Mar 25. Epub 2019 Mar 25.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN. Electronic address:

Thyrotoxicosis is the clinical manifestation of excess thyroid hormone action at the tissue level due to inappropriately high circulating thyroid hormone concentrations. Hyperthyroidism, a subset of thyrotoxicosis, refers specifically to excess thyroid hormone synthesis and secretion by the thyroid gland. We performed a review of the literature on these topics utilizing published data in PubMed and MEDLINE. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.10.011DOI Listing
March 2019
1 Read

Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children.

Pediatr Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Background/objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) is rare but potentially fatal in children. Fever and rash, which are salient features of DRESS, may mimic other commonly encountered pediatric conditions. We profiled the DRESS cases in a tertiary children's hospital in Singapore. Read More

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http://dx.doi.org/10.1111/pde.13812DOI Listing
March 2019
1 Read

Epidemiology of hyperthyroidism in Iran: a systematic review and meta-analysis.

J Diabetes Metab Disord 2018 Dec 16;17(2):345-355. Epub 2018 Nov 16.

1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Hyperthyroidism is a systemic disorder that causes severe morbidity and is even fatal. Several studies have been performed in Iran to determine the epidemiologic properties of hyperthyroidism; however, they did not use a systematic approach or meta-analysis to evaluate the results. Therefore, this systematic review and meta-analysis aimed to evaluate the epidemiologic data on hyperthyroidism in Iran. Read More

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https://jdmdonline.biomedcentral.com/articles/10.1007/s40200
Publisher Site
http://dx.doi.org/10.1007/s40200-018-0367-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405392PMC
December 2018
9 Reads

[Surgical management of hyperthyroidism: about 60 cases].

Pan Afr Med J 2018 20;31:43. Epub 2018 Sep 20.

Service d'Oto-Rhino-Laryngologie, Hôpital Militaire Avicenne, Marrakech, Maroc.

Hyperthyroidism includes several diseases characterized by high level of circulating thyroid hormones. Thyroidectomy is one of the main treatment options. We conducted a retrospective study to evaluate the epidemiological, clinical, therapeutic, evolutionary features of patients who had undergone surgery for hyperthyroidism in the ENT Department at the Avicenne Military Hospital in Marrakech. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.43.16695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430848PMC
April 2019
1 Read

The long-term follow-up of patients with thionamide-treated Graves' hyperthyroidism.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Since there have been few reports on the long-term prognosis of Graves' hyperthyroidism, the prognosis of 549 Graves' hyperthyroidism patients initially treated with thionamide and followed for >8 (range: 8.6-36.4) years was studied, evaluating the change in the TSH binding inhibitor immunoglobulin activity (TBII). Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0418DOI Listing
March 2019
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Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy.

Int J Endocrinol 2019 20;2019:1384651. Epub 2019 Feb 20.

Department of Internal Medicine, Division of Diabetes, Endocrine and Metabolism, University of Nebraska Medical Center, Omaha, NE, USA.

Objective: We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG.

Methods: This is a prospective, observational pilot study. We approved and enrolled 50 subjects ≥ 19 years scheduled for total thyroidectomy and measured serum TG, thyroglobulin antibody (TG ab), and TSH preoperatively and post thyroidectomy at 7-14 days, 4 and 6 weeks, and 3 months in subjects with benign pathology, with additional 6- and 12-month measurements in subjects with thyroid cancer. Read More

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http://dx.doi.org/10.1155/2019/1384651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402205PMC
February 2019
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Graves' Disease: Can It Be Cured?

Endocrinol Metab (Seoul) 2019 Mar;34(1):29-38

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Whether or not Graves' hyperthyroidism can be really cured, depends on the definition of "cure." If eradication of thyroid hormone excess suffices for the label "cure," then all patients can be cured because total thyroidectomy or high doses of ¹³¹I will abolish hyperthyroidism albeit at the expense of creating another disease (hypothyroidism) requiring lifelong medication with levothyroxine. I would not call this a "cure," which I would like to define as a state with stable thyroid stimulating hormone (TSH), free thyroxine, and triiodothyronine serum concentrations in the normal range in the absence of any thyroid medication. Read More

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http://dx.doi.org/10.3803/EnM.2019.34.1.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435849PMC
March 2019
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Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study.

J Trace Elem Med Biol 2019 May 12;53:55-61. Epub 2019 Feb 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam College of Medicine, Daegu, Republic of Korea. Electronic address:

Previous studies on blood cadmium (BCd) and changes in thyroid hormone levels are controversial. We investigated whether thyroid hormone levels and thyroid function status were associated with BCd according to sex in the Korean population. Our study included 1972 participants based on the 2013 Korea National Health and Nutrition Examination Survey (KNHANES) data. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.003DOI Listing
May 2019
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Acute myocardial infarction in pregnancy: spasm caused by hyperthyroidism?

J Int Med Res 2019 Mar 26:300060519837833. Epub 2019 Mar 26.

Department of Cardiology, Taizhou First People's Hospital, Wenzhou Medical University, Taizhou, Zhejiang Province, China.

We present a 26-year-old woman with ST-segment elevation myocardial infarction in the 14th week of pregnancy. Coronary angiography revealed no abnormalities in the coronary arteries. She had no history of coronary risk factors such as smoking, diabetes mellitus, hypertension, or dyslipidemia. Read More

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http://dx.doi.org/10.1177/0300060519837833DOI Listing
March 2019
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Hyperthyroidism influences renal function.

Endocrine 2019 Mar 23. Epub 2019 Mar 23.

Department of Internal Medicine, Health Sciences University, Kecioren Teaching and Research Hospital, Keçiören/Ankara, Turkey.

Purpose: While the effects of hypothyroidism on renal function have been studied extensively, there is less information concerning the effect of hyperthyroidism. We aimed to elucidate the effect of overt and subclinical hyperthyroidism, on estimated glomerular filtration rate (eGFR) with large number of patients treated for hyperthyroidism and after euthyroidism was achieved.

Method: A total of 433 consecutive overt and subclinical hyperthyroid patients were included in the study. Read More

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http://dx.doi.org/10.1007/s12020-019-01903-2DOI Listing
March 2019
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Influence of Thyroid-stimulating Hormone Suppression Therapy on Bone Mineral Density in Patients with Differentiated Thyroid Cancer: A Meta-analysis.

J Bone Metab 2019 Feb 28;26(1):51-60. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The effects of subclinical hyperthyroidism on bone mineral density (BMD) induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with differentiated thyroid cancer (DTC) remains unclear. We conducted a meta-analysis to determine the influence of TSH suppression therapy on BMD.

Methods: We performed a systematic search to identify studies which included BMD measurement of femoral neck, total hip or lumbar spine in patients on TSH suppression therapy for DTC. Read More

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http://dx.doi.org/10.11005/jbm.2019.26.1.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416150PMC
February 2019
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Risk of Osteoporotic Fractures after Thyroid-stimulating Hormone Suppression Therapy in Patients with Thyroid Cancer.

J Bone Metab 2019 Feb 28;26(1):45-50. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The effects of subclinical hyperthyroidism on fracture risk induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with thyroid cancer still remains controversial. We performed a meta-analysis and systematic review to evaluate the effects of TSH suppression therapy on osteoporotic fracture in patients with thyroid cancer.

Methods: We performed a systematic search to identify studies which included osteoporotic fractures (hip fracture and vertebral fracture) in patients on TSH suppression therapy for thyroid cancer. Read More

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http://dx.doi.org/10.11005/jbm.2019.26.1.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416149PMC
February 2019
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Rapid Changes of Thyroid Function in a Young Woman with Autoimmune Thyroid Disease.

Med Princ Pract 2019 Mar 22. Epub 2019 Mar 22.

Objective
A conversion from Hashimoto's thyroiditis (HT) to Graves' disease (GD) and vice versa leads to diagnostic and therapeutic challenges.
Clinical Presentation and Intervention
A 30-year old woman presented with overt hyperthyroidism and negative thyroid-stimulating hormone receptor antibodies (TRAbs). Since hashitoxicosis was assumed, the patient was treated with propranolol. Read More

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http://dx.doi.org/10.1159/000499754DOI Listing
March 2019
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Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.

Endocrinol Diabetes Metab Case Rep 2019 Mar 21;2019. Epub 2019 Mar 21.

Oxford Centre for Endocrinology, Diabetes and Metabolism, Churchill Hospital, Oxford, UK.

A 21 year-old woman was found to have a pituitary macroadenoma following an episode of haemophilus meningitis. Biochemical TSH and GH excess was noted, although with no clear clinical correlates. She was treated with a somatostatin analogue (SSA), which restored the euthyroid state and controlled GH hypersecretion, but she re-presented with a further episode of cerebrospinal fluid (CSF) leak and recurrent meningitis. Read More

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http://dx.doi.org/10.1530/EDM-18-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432976PMC
March 2019
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Inflammatory disease and C-reactive protein in relation to therapeutic ionising radiation exposure in the US Radiologic Technologists.

Sci Rep 2019 Mar 20;9(1):4891. Epub 2019 Mar 20.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9778, USA.

Chronic inflammation underlies many autoimmune diseases, including hypothyroidism, hyperthyroidism, and rheumatoid arthritis, also type-2 diabetes and osteoarthritis. Associations have been suggested of high-dose ionising radiation exposure with type-2 diabetes and elevated levels of C-reactive protein, a marker of chronic inflammation. In this analysis we used a proportional hazards model to assess effects of radiotherapy on risks of subsequent inflammatory disease morbidity in 110,368 US radiologic technologists followed from a baseline survey (1983-1989/1994-1998) through 2008. Read More

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http://www.nature.com/articles/s41598-019-41129-w
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http://dx.doi.org/10.1038/s41598-019-41129-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426979PMC
March 2019
7 Reads

Excess iodine intake: sources, assessment, and effects on thyroid function.

Ann N Y Acad Sci 2019 Mar 20. Epub 2019 Mar 20.

Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.

Iodine is essential for thyroid hormone synthesis. High iodine intakes are well tolerated by most healthy individuals, but in some people, excess iodine intakes may precipitate hyperthyroidism, hypothyroidism, goiter, and/or thyroid autoimmunity. Individuals with preexisting thyroid disease or those previously exposed to iodine deficiency may be more susceptible to thyroid disorders due to an increase in iodine intake, in some cases at intakes only slightly above physiological needs. Read More

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http://dx.doi.org/10.1111/nyas.14041DOI Listing
March 2019
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