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    In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay.
    J Pediatr Endocrinol Metab 2018 Feb 21. Epub 2018 Feb 21.
    Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine, Columbus, OH, USA.
    Background: Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly.

    Case Presentation: We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)<0.015 (0. Read More

    Maternal thyroid function and child educational attainment: prospective cohort study.
    BMJ 2018 Feb 20;360:k452. Epub 2018 Feb 20.
    Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
    Objective: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment.

    Design: Prospective cohort study.

    Setting: Avon Longitudinal Study of Parents and Children cohort in the UK. Read More

    Type 1 diabetes mellitus and Graves' disease in Down's syndrome--a rare combination.
    Afr J Med Med Sci 2016 Sep;45(3):299-301
    Background: Autoimmune diseases including thyroid. disorders, type 1 diabetes and celiac disease are commoner in persons with Down's syndrome compared with the general population. Coexistent type 1 diabetes and hyperthyroidism in Down's syndrome is however not commonly reported in literature. Read More

    Bone densitometry status and its associated factors in peri and post menopausal females: A cross sectional study from a tertiary care centre in India.
    Taiwan J Obstet Gynecol 2018 Feb;57(1):100-105
    Army College of Medical Sciences, New Delhi, India.
    Objective: Osteoporosis is a skeletal disorder characterized by diminished bone strength that increases the risk of fracture at instances of trivial trauma. Asians have a lower bone mass than the west. The present study was designed to add data from India on women above the age of 40 years with respect to low bone mineral density (BMD) and its associated high risk factors. Read More

    A case of sudden onset of thyroid storm just before cesarean section manifesting congestive heart failure and pulmonary edema.
    JA Clin Rep 2017 26;3(1):20. Epub 2017 Apr 26.
    Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano 390-8621 Japan.
    Background: Since acute respiratory failure (ARF) is a life-threatening complication, particularly in the gestational period, differential diagnosis and rapid treatment are required. Among the various causes of sudden onset of ARF, thyroid storm is a rare cause in a parturient complicated with well-controlled hyperthyroidism. In this case report, we describe a parturient with hyperthyroidism in whom a thyroid storm manifesting congestive heart failure and pulmonary edema developed just before an emergency ceasarean section, even though hyperthyroidism was well-controlled with antithyroid drugs. Read More

    Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report.
    J Med Case Rep 2018 Feb 16;12(1):38. Epub 2018 Feb 16.
    Departamento de Endocrinología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
    Background: Exophthalmos, myxedema, and osteoarthropathy syndrome is a very rare condition that is associated with Graves' disease. The presence of dermopathy and the involvement of joint/bone tissues indicate that it seems to be related with the severity of the autoimmune process. Owing to its low incidence, there is a lack of information regarding its treatment and clinical follow-up. Read More

    Thyroid carcinoma producing β-human chorionic gonadotropin shows different clinical behavior.
    Pathol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Shandong University School of Basic Medical Sciences, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.
    Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. Read More

    High prevalence of HCV (GT4)-related TSH abnormality among 13402 Egyptian patients treated with direct acting antiviral therapy.
    Hepatol Int 2018 Feb 14. Epub 2018 Feb 14.
    Hepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
    Background: HCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs).

    Methods: Patients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016. Read More

    Graves' disease coexisting with resistance to thyroid hormone: a rare case.
    Clin Case Rep 2018 Feb 29;6(2):337-341. Epub 2017 Dec 29.
    Endocrine and Diabetes CenterAffiliated Hospital of Integrated Traditional Chinese and Western MedicineJiangsu Province Academy of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina.
    A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland. Read More

    Body weight change is unpredictable after total thyroidectomy.
    ANZ J Surg 2018 Feb 14. Epub 2018 Feb 14.
    Monash University Endocrine Surgery Unit, The Alfred Hospital, Melbourne, Victoria, Australia.
    Background: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery.

    Methods: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014. Read More

    A thyroid storm patient with protracted disturbance of consciousness and reversible lesion in the splenium of corpus callosum: A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9949
    Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Johnan-cho, Hitachi, Ibaraki, Japan.
    Rationale: Various neurological manifestations are observed in thyroid storm patients but protracted disturbance of consciousness is rare.

    Patient Concerns: A 58-year-old male was admitted to our hospital after a traffic accident.

    Diagnoses: Although awake on arrival, he fell into coma after admission. Read More

    Qualitative and quantitative salivary changes and subjective oral dryness among patients with thyroid dysfunction.
    Indian J Dent Res 2018 Jan-Feb;29(1):16-21
    Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
    Context: There is a paucity of literature regarding the effects of thyroid disorders on the oral cavity by influencing the salivary gland function.

    Aims: This study aims to understand the qualitative and quantitative changes that thyroid disorder can cause in the salivary function.

    Settings And Design:: After obtaining ethical clearance, 46 consecutive newly diagnosed thyroid dysfunction patients were enrolled in this cross-sectional study, along with 45 age-and sex-matched controls. Read More

    Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis.
    J Community Hosp Intern Med Perspect 2018 6;8(1):35-37. Epub 2018 Feb 6.
    Department of Medicine/Division of Rheumatology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
    Propylthiouracil (PTU) is a commonly used medication for the treatment of hyperthyroidism. PTU is known to cause different adverse reactions including autoimmune syndromes. PTU-induced autoimmune syndromes can be classified into drug-induced lupus or drug-induced vasculitis. Read More

    Prevalence of subclinical hypothyroidism in adults visiting primary health-care setting in Riyadh.
    J Community Hosp Intern Med Perspect 2018 6;8(1):11-15. Epub 2018 Feb 6.
    Department of Family Medicine & Primary Health Care, King Abdul Aziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
    : Subclinical hypothyroidism is an asymptomatic condition with normal thyroxin and raised thyroid stimulating hormone (TSH) level. The objective of the study was to determine the prevalence of subclinical hypothyroidism in primary health care (PHC) settings in Riyadh and explore the relationship of TSH level with age, gender, family history, body mass index, and co-morbid conditions.: A cross-sectional study of adult visitors to nine satellites PHC clinics in military housing in Riyadh was carried out. Read More

    Effect of thyroglobulin autoantibodies on the metabolic clearance of serum thyroglobulin.
    Thyroid 2018 Feb 14. Epub 2018 Feb 14.
    Endocrinology Unit I, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Italy, Pisa, Italy ;
    Background: To establish whether thyroglobulin autoantibodies (TgAb) influence the metabolic clearance of thyroglobulin (Tg) in humans, we correlated serum Tg and TgAb shortly after 131I treatment.

    Methods: Samples were collected from 30 consecutive patients undergoing 131I activity for Graves' hyperthyroidism at the time of treatment and every 15 days thereafter, up to 90 days. Tg and TgAb were measured by immunometric assays (functional sensitivities: 0. Read More

    Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves' disease.
    Auto Immun Highlights 2018 Feb 12;9(1). Epub 2018 Feb 12.
    Clinical Pathology Laboratory, S. Maria degli Angeli Hospital, Pordenone, Italy.
    Purpose: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs.

    Methods: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiAanti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAKRIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the ImmuliteTSI assay (Siemens Healthcare, Llanberis, UK). Read More

    A Case of Heart Failure with Hyperthyroidism Demonstrating Discrepancy between the Clinical Course and B-type Natriuretic Peptide Levels.
    Intern Med 2018 Feb 9. Epub 2018 Feb 9.
    Heart Center, Department of Cardiology, Juntedo University Urayasu Hospital, Japan.
    A 35-year-old Japanese man was emergently admitted to our hospital with chief complaints of palpitation and dyspnea. He has been treated for Basedow's disease. He was diagnosed with acute decompensated heart failure, atrial fibrillation and thyrotoxicosis. Read More

    Effects of thyroid hormones on thermogenesis and energy partitioning.
    J Mol Endocrinol 2018 Feb 6. Epub 2018 Feb 6.
    G Brabant, Experimental and Clinical Endocrinology, Medizinische Klinik I Ratzeburger Allee 160, 23538 Lübeck, Germany, Lübeck, Germany
    Thyroid hormones (TH) are of central importance for thermogenesis, energy homeostasis, and metabolism. Here we will discuss these aspects by focussing on the physiological aspects of TH-dependent regulation in response to cold exposure and fasting which will be compared to alterations in primary hyper- and hypothyroidism. In particular, we will summarise current knowledge on regional thyroid hormone status in the central nervous system (CNS) and in peripheral cells. Read More

    Clinicopathological features and comorbidities of cats with mild, moderate or severe hyperthyroidism: a radioiodine referral population.
    J Feline Med Surg 2018 Feb 1:1098612X18755925. Epub 2018 Feb 1.
    4 The Feline Centre, Langford Vets, Bristol, UK.
    Objectives This study sought to explore the clinicopathological features and comorbidities of cats with mild, moderate and severe hyperthyroidism in a radioiodine referral population. Methods Medical records were reviewed, along with results of serum biochemistry, urinalysis, systolic blood pressure and diagnostic imaging performed at the time of radioiodine referral. Cats were grouped by total thyroxine (TT4) levels as mildly (TT4 60. Read More

    Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):701-710. Epub 2017 Nov 29.
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan.
    Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Read More

    An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodular goitre.
    Malays Fam Physician 2017 31;12(2):29-31. Epub 2017 Aug 31.
    MD (USM), MMed (Family Medicine ) (USM), Universiti Sains Malaysia, Kelantan, Malaysia Email:
    Introduction: The association of myasthenia gravis (MG) with other autoimmune diseases including autoimmune thyroid disease (ATD) is well recognised, although rare. The occurrence of both diseases can occur in two ways: either disease preceding the other, or concurrently. The presentation of MG in association with ATD can range from ocular to generalised disease. Read More

    Thyroid function test evolution in children with Hashimoto's thyroiditis is closely conditioned by the biochemical picture at diagnosis.
    Ital J Pediatr 2018 Feb 7;44(1):22. Epub 2018 Feb 7.
    Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
    ᅟ: Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto's thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH) are more prone to the risk of developing severe thyroid dysfunctions over time, if compared to those presenting with euthyroidism. In contrast, children presenting with HT and either overt or subclinical hyperthyroidism are incline to exhibit a definitive resolution of the hyperthyroid phase within some months, although there is a wide variability between the different individuals. Read More

    Long-term outcomes of thyroid dysfunction in patients with chronić hepatitis C treated with pegylated interferon alpha and ribavirin
    Przegl Epidemiol 2017 ;71(4):555-569
    Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
    Introduction: Thyroid dysfunctions (TDs) are associated with pegylated interferon and ribavirin (PegIFN-α/RBV) therapy in patients with chronic hepatitis C (CHC) and are considered as possible extrahepatic manifestation of HCV infection

    Objectives: This study aimed to assess the long-term outcomes of TDs in patients with CHC treated with PegIFN-α/RBV

    Methods: A total of 1,047 treatment-naïve patients with CHC were treated with PegIFN-α/RBV. TSH and FT4 were assessed at baseline, every 3 months during therapy and 6, 12 and 24 months after the end of therapy. Analysis was performed for two groups of patients depending on the absence (group A, n=77) or presence (group B, n=39) of TDs at baseline

    Results: At baseline, TDs’ prevalence was 3. Read More

    Thyroid disorders in obese patients. Does insulin resistance make a difference?
    Arch Endocrinol Metab 2017 Dec;61(6):575-583
    Department of Endocrinology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.
    Objective: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients.

    Subjects And Methods: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound. Read More

    A single session of laser ablation for toxic thyroid nodules: three-year follow-up results.
    Int J Hyperthermia 2018 Feb 22:1-5. Epub 2018 Feb 22.
    b Studio Tiroide Prof. De Feo , Perugia , Italy.
    Purpose: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up.

    Material And Methods: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goitre. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated. Read More

    Thyroid Hormone Role and Economy in the Developing Testis.
    Vitam Horm 2018 25;106:473-500. Epub 2017 Jul 25.
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, United States. Electronic address:
    Thyroid hormones (TH) exhibit pleiotropic regulatory effects on growth, development, and metabolism, and it is becoming increasingly apparent that the developing testis is an important target for them. Testicular development is highly dependent on TH status. Both hypo- and hyperthyroidism affect testis size and the proliferation and differentiation of Sertoli, Leydig, and germ cells, with consequences for steroidogenesis, spermatogenesis, and male fertility. Read More

    Thyroid Hormone in the CNS: Contribution of Neuron-Glia Interaction.
    Vitam Horm 2018 17;106:313-331. Epub 2017 Jul 17.
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:
    The endocrine system and the central nervous system (CNS) are intimately linked. Among hormones closely related to the nervous system, thyroid hormones (THs) are critical for the regulation of development and differentiation of neurons and neuroglia and hence for development and function of the CNS. T3 (3,3',5-triiodothyronine), an active form of TH, is important not only for neuronal development but also for differentiation of astrocytes and oligodendrocytes, and for microglial development. Read More

    Thyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules.
    Vitam Horm 2018 5;106:147-162. Epub 2017 Jun 5.
    School of Life and Medical Sciences, Hertfordshire University, Hatfield, United Kingdom. Electronic address:
    Thyroid hormone receptors (TRs) are nuclear receptors which control transcription, and thereby have effects in all cells within the body. TRs are an important regulator in many basic physiological processes including development, growth, metabolism, and cardiac function. The hyperthyroid condition results from an over production of thyroid hormones resulting in a continual stimulation of thyroid receptors which is detrimental for the patient. Read More

    Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases.
    J Altern Complement Med 2018 Feb 6. Epub 2018 Feb 6.
    1 Department of Endocrinology, Traditional Chinese Medicine Hospital of Shanxi , Xi'an, China .
    Purpose: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines.

    Methods: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone. Read More

    Neonatal Thyrotoxicosis.
    Clin Perinatol 2018 Mar 16;45(1):31-40. Epub 2017 Dec 16.
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, The Thyroid Center, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:
    Neonatal thyrotoxicosis (hyperthyroidism) is less prevalent than congenital hypothyroidism; however, it can lead to significant morbidity and mortality if not promptly recognized and adequately treated. Most cases are transient, secondary to maternal autoimmune hyperthyroidism (Graves disease [GD]). This article summarizes recommendations for screening and management of hyperthyroidism in both the fetal and neonatal periods, with a focus on neonatal thyrotoxicosis secondary to maternal GD. Read More

    Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats.
    Bratisl Lek Listy 2018 ;119(1):32-35
    Irisin is a newly discovered myokine and adipokine that increases total body energy expenditure. The aim of this study was to determine the effect of experimental hypothyroidism and hyperthyroidism on the levels of irisin in heart tissue in rats. The study was performed on the 40 male Sprague-Dawley rats. Read More

    Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mg/Day) of Methimazole in the Induction of Euthyroidism in Graves' Hyperthyroidism: A Randomized Controlled Study.
    Int J Endocrinol 2017 18;2017:2619695. Epub 2017 Dec 18.
    Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Previous studies used unequal or high daily dosages of methimazole (MMI) to compare the efficacy of once daily dose regimen (OD-MMI) with that of divided daily doses regimen (DD-MMI) in inducing euthyroidism.

    Objectives: To compare the efficacy of OD-MMI to that of DD-MMI using low daily dosage of MMI in inducing euthyroidism.

    Methods: Fifty patients with clinically nonsevere Graves' hyperthyroidism were randomized to be treated with 15 mg/day OD-MMI or 15 mg/day DD-MMI. Read More

    [Medical Treatment of Thyroid Nodule].
    Laryngorhinootologie 2018 Feb 5;97(2):89-91. Epub 2018 Feb 5.
    Whereas in regions with sufficient iodide intake treatment of thyroid nodules with levothyroxine has been almost completely abandoned and is also not further recommended by guidelines, medical treatment may be still indicated in Germany as recently demonstrated by randomized, placebo-controlled LISA study.A major reason for this is mild iodide deficiency in patients with thyroid nodules. In LISA study a combined therapy of levothyroxine and iodide resulted in an at least 50 % reduction of nodular volume in 21,6 % of treated patient compared to in only 5,2 % of placebo-treated patients. Read More

    Frequency of Thyroid-Stimulating Hormone Monitoring in Patients After Thyroidectomy: A Retrospective Study in Primary Care Practices in Germany.
    Exp Clin Endocrinol Diabetes 2018 Feb 2. Epub 2018 Feb 2.
    Faculty of Medicine, University of Paris 5, Paris, France.
    Aim: The goal of this study was to analyze the frequency of thyroid-stimulating hormone (TSH) monitoring in thyroidectomy patients followed by general practitioners in Germany.

    Methods: This study included all individuals ≥18 years who had undergone a thyroidectomy between 2000 and 2015 in 258 general practices in Germany. Another inclusion criterion was a minimum of three medical visits between 2015 and 2016, following thyroidectomy. Read More

    [Investigation of tall stature in children: Diagnostic work-up, review of the main causes].
    Arch Pediatr 2018 Feb 1;25(2):163-169. Epub 2018 Feb 1.
    Service de pédiatrie multidisciplinaire, hôpital Timone Enfants, Assistance publique des hôpitaux de Marseille, 264, rue Saint-Pierre, 13385 Marseille, France.
    Tall stature is not a common motive for medical consultation, even though by definition 2.5 % of children in the general population are concerned. It is usually defined as height greater than+2 standard deviations (SD) using the appropriate growth chart for age and gender, or a difference greater than +2 SD between actual height and target height. Read More

    Transiently Altered Distribution of F-18 FDG in a Patient with Subacute Thyroiditis.
    Nucl Med Mol Imaging 2018 Feb 17;52(1):82-84. Epub 2016 Oct 17.
    Department of Nuclear Medicine, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, 895, Muwang-ro, Iksan, 54538 Republic of Korea.
    F-18 fluorodeoxyglucose (FDG) is a highly influential radiotracer that provides valuable information in many cancer types. However, the normal biodistribution of F-18 FDG is often variable and can be altered by intrinsic or iatrogenic factors. We report a case of diffuse symmetrically increased skeletal muscle uptake and relatively decreased hepatic uptake on F-18 FDG PET/CT in a 57-year-old female with pulmonary adenocarcinoma. Read More

    ANCA positive relapsing polychondritis, Graves disease, and suspected moyamoya disease: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9378
    Department of Rheumatology and Immunology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, P.R. China.
    Ratioinale: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Read More

    Insulin autoimmune syndrome in a pregnant female: A rare case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9213
    Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS.

    Patient Concerns: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. Read More

    Ectopic thyrotropin secreting pituitary adenoma concomitant with papillary thyroid carcinoma: Case report.
    Medicine (Baltimore) 2017 Dec;96(50):e8912
    Department of Endocrinology.
    Rationale: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. Read More

    Indications and contraindications to transoral thyroidectomy.
    Ann Thyroid 2017 31;2(5). Epub 2017 Oct 31.
    Division of Head and Neck Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Patient motivation to avoid neck scarring has been a strong impetus in the development of remote access approaches to the thyroid, including transoral robotic or endoscopic thyroidectomy vestibular approach (TOR/ETVA). TOR/ETVA continues to become more prevalent given its early success in North America and the demonstration of its safety and efficacy in Asia. As more surgeons perform this procedure, it is important that specific and uniform indications and contraindications exist to prevent surgical complications due to poor patient selection. Read More

    Thyroid-associated orbitopathy in patients with thyroid carcinoma: A case report of 5 cases.
    Medicine (Baltimore) 2017 Nov;96(47):e8768
    Department of Internal Medicine.
    Rationale: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. Read More

    Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism.
    J Vet Intern Med 2018 Jan;32(1):295-304
    University of Minnesota College of Veterinary Medicine , St. Paul, MN.
    Background: Hyperthyroidism can complicate (mask) the diagnosis of chronic kidney disease (CKD) because it increases glomerular filtration rate and decreases body muscle mass, both of which can lower serum creatinine concentrations. Currently, there is no clinical test that can reliably predict which hyperthyroid cats have concurrent azotemic CKD that will become apparent after treatment of the hyperthyroidism.

    Objectives: To investigate serum symmetric dimethylarginine (SDMA) concentration as a potential marker of masked azotemia in untreated hyperthyroid cats. Read More

    Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer.
    Endocrine 2018 Jan 27. Epub 2018 Jan 27.
    Department of Endocrinology and Metabolism, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.
    Purpose: We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).

    Methods: Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded. Read More

    Thyrotoxic Neuropathy: A rare cause of acute flaccid paraplegia.
    Sultan Qaboos Univ Med J 2017 Nov 10;17(4):e460-e463. Epub 2018 Jan 10.
    Department of Neurology, Royal Hospital, Muscat, Oman.
    Acute polyneuropathy is a rare manifestation of severe hyperthyroidism. We report a 22-year-old Omani male who presented to the Sohar Hospital, Sohar, Oman, in 2016 with acute-onset rapidly progressive flaccid areflexic paraplegia as the presenting manifestation of thyrotoxicosis. Nerve conduction studies revealed mixed axonal and demyelinating polyneuropathy in both the motor and sensory nerves. Read More

    Prevalence and risk factors for hyperthyroidism in Irish cats from the greater Dublin area.
    Ir Vet J 2018 15;71. Epub 2018 Jan 15.
    1Section of Small Animal Clinical Studies, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
    Background: Hyperthyroidism is common in older cats. Prevalence varies geographically, but is anecdotally considered low in Ireland. The aim of this study was to document prevalence of hyperthyroidism in older cats in the greater Dublin area of Ireland and to assess environmental and clinical associations for development and identification of the disease. Read More

    Melanoma in the shopping mall: A utilitarian argument for offering unsolicited medical opinions in informal settings.
    Bioethics 2018 Mar 25;32(3):193-198. Epub 2018 Jan 25.
    Doctors occasionally make diagnoses in strangers outside of formal medical settings by using the medical skill of visual inspection, such as noticing signs of melanoma or the symptoms of hyperthyroidism. This may cause considerable moral unease and doubts on the side of the diagnosing physician. Such encounters force physicians to consider whether or not to intervene by introducing themselves to the stranger and offering an unsolicited medical opinion despite the absence of a formal doctor-patient relationship. Read More

    Effects of the dopamine Dreceptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model.
    Andrologia 2018 Jan 25. Epub 2018 Jan 25.
    Department of Urology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
    Various factors are involved in the aetiology of premature ejaculation (PE). Hyperthyroidism is one of the causes of acquired PE, but the exact mechanism by which it causes the disorder is not yet understood. The aim of this study was to evaluate the role of the dopaminergic system in hyperthyroidism-induced PE by the intracerebroventricular microinjection of the preferentially active dopamine receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in a rat model of this disorder. Read More

    Biased signaling by thyroid-stimulating hormone receptor-specific antibodies determines thyrocyte survival in autoimmunity.
    Sci Signal 2018 Jan 23;11(514). Epub 2018 Jan 23.
    Thyroid Research Unit, Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY 10029, USA.
    The thyroid-stimulating hormone receptor (TSHR) is a heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR). Autoimmune hyperthyroidism, commonly known as Graves' disease (GD), is caused by stimulating autoantibodies to the TSHR. We previously described TSHR-specific antibodies (TSHR-Abs) in GD that recognize linear epitopes in the cleavage region of the TSHR ectodomain (C-TSHR-Abs) and induce thyroid cell apoptosis instead of stimulating the TSHR. Read More

    [Struma ovarii associated with Graves' disease].
    Medicina (B Aires) 2018 ;78(1):44-46
    Servicio de Endocrinología, Servicio de Endocrinología y Metabolismo, Complejo Médico Churruca-Visca, Buenos Aires, Argentina.
    Hyperthyroidism is defined as an excessive production of thyroid hormones by eutopic or ectopic mature thyroid tissue. The overall prevalence of hyperthyroidism is 1.2% and the most common cause is Graves' disease. Read More

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