Front Pharmacol 2021 20;12:664319. Epub 2021 Apr 20.
College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
As the treatments of diseases with Chinese herbs are holistic and characterized by multiple components, pathways, and targets, elucidating the efficacy of Chinese herbs in treating diseases, and their molecular basis, requires a comprehensive, network-based approach. In this study, we used a network pharmacology strategy, as well as proteomics and metabonomics, to reveal the molecular basis by which rhizome (AMR) ameliorates hypothyroidism. Eighteen main compounds from AMR and its fractions (volatile oil fraction, crude polysaccharides fraction, lactones fraction, oligosaccharide fraction, and atractyloside fraction) were identified by HPLC, and their targets were screened using the TCMSP database and Swiss Target Prediction. Read More