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    Iron metabolism in patients with Graves' hyperthyroidism.
    Clin Endocrinol (Oxf) 2017 Aug 18. Epub 2017 Aug 18.
    Division of Endocrinology and Diabetes, Luzerner Kantonsspital, 6000, Luzern, Switzerland.
    Objectives: Graves' hyperthyroidism (GH) interferes with iron metabolism and elevates ferritin. The precise mechanisms remain unclear. The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized. Read More

    Design and implementation of a mobile gamma spectrometry system to in vivo measure the accumulated activity of (131)I in patients with thyroid diseases.
    Appl Radiat Isot 2017 Aug 13;129:87-95. Epub 2017 Aug 13.
    Universidad de La Frontera, Temuco, Chile.
    The design and implementation of a mobile gamma spectrometry system to in vivo measure the accumulated activity of (131)I in whole body and thyroid of patients with thyroid diseases are presented in this work. This system may be used for both pre-therapeutic and post-therapeutic dosimetry calculations. It consists of a detector and a movable support that allows its movement from one place to another. Read More

    Cancer immunotherapy-induced endocrinopathies: Clinical behavior and therapeutic approach.
    Eur J Intern Med 2017 Aug 18. Epub 2017 Aug 18.
    Department of Endocrinology, Hospital Ramón y Cajal, Ctra. de Colmenar, Km 9.100, 28034 Madrid, Spain. Electronic address:
    Cancer immunotherapy has proven to be effective in a wide variety of tumors. The use of immune checkpoint blocking monoclonal antibodies has become a standard treatment regimen in some of them as advanced melanoma. However, given the mechanism of action, its use may be associated with immune-related adverse events that may complicate the clinical course and prognosis of patients. Read More

    Prevalence of and risk factors for feline hyperthyroidism in South Africa.
    J Feline Med Surg 2016 Dec 1:1098612X16684408. Epub 2016 Dec 1.
    1 Department of Companion Animal Clinical Studies, University of Pretoria, South Africa.
    Objectives Hyperthyroidism is a disorder of older cats that may have a geographical variation in prevalence. Prevalence studies have not yet been performed in South Africa, a geographical area where hyperthyroidism in cats has recently been observed and where, reportedly, the incidence appears to be increasing. The purpose of this study was to determine the prevalence of feline hyperthyroidism in South Africa and to identify any potential risk factors. Read More

    Atrial fibrillation and hyperthyroidism: A literature review.
    Indian Heart J 2017 Jul - Aug;69(4):545-550. Epub 2017 Jul 5.
    Department of Cardiology, Wayne State University, Detroit Medical Center, 4201 St. Antoine Street, Detroit, MI, 48201, United States.
    Atrial fibrillation is the most common arrhythmia worldwide with increasing frequency noted with age. Hyperthyroidism is a well-known cause of atrial fibrillation with a 16%-60% prevalence of atrial fibrillation in patients with known hyperthyroidism Ross et al. (2016). Read More

    Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies.
    J Stroke Cerebrovasc Dis 2017 Aug 15. Epub 2017 Aug 15.
    Department of Internal Medicine, Rheumatology, Mayo Clinic, Rochester, Minnesota.
    Background: Stroke is the fifth leading cause of mortality in the United States and a leading cause of disability. A complex relationship between thyroid hormone levels and severity of, and outcome after, stroke has been described.

    Aim: Our objective is to identify the association between baseline thyroid function profile and outcome after acute ischemic stroke. Read More

    History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
    Br J Cancer 2017 Aug 17. Epub 2017 Aug 17.
    Deparment of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
    Background: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited.

    Methods: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Read More

    Perimesencephalic nonaneurysmal subarachnoid hemorrhage caused by transverse sinus thrombosis: A case report and review of literature.
    Medicine (Baltimore) 2017 Aug;96(33):e7374
    aDepartment of Neurology bDepartment of Radiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou cFrom the Department of Neurology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang Province dFrom the Department of Neurology, Zhengzhou People's Hospital, Zhengzhou, Henan Province, China.
    Rationale: Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSAH) is characterized by a pattern of extravasated blood restricted to the perimesencephalic cisterns, normal angiographic findings, and an excellent prognosis with an uneventful course and low risks of complication. The precise etiology of bleeding in patients with PNSAH has not yet been established. The most common hypothesis is that PNSAH is venous in origin. Read More

    Endocr Pract 2017 Aug 17. Epub 2017 Aug 17.
    Rheumatology Department, Federal University of Uberlândia, Brazil.
    Objectives: Because routine investigations are necessary for the early detection of thyroid disease, this study aimed to assess the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunction (TD) in patients with systemic lupus erythematosus (SLE).

    Methods: Seventy-nine SLE patients (American College of Rheumatology criteria) and 159 control patients with no diagnosis of autoimmune diseases (except for ATD) were consecutively evaluated regarding changes in laboratory assessments of thyroid function and the presence of ATD.

    Results: ATD was detected in 11. Read More

    The role of radiopharmaceuticals in Amiodarone-induced thyroid pathology.
    Curr Radiopharm 2017 Aug 16. Epub 2017 Aug 16.
    Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca. Romania.
    Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Read More

    Etiologies and management of cutaneous flushing: Nonmalignant causes.
    J Am Acad Dermatol 2017 Sep;77(3):391-402
    Department of Dermatology, Tulane University, New Orleans, Louisiana.
    The flushing phenomenon may represent a physiologic or a pathologic reaction. Although flushing is usually benign, it is prudent that the physician remains aware of potentially life-threatening conditions associated with cutaneous flushing. A thorough investigation should be performed if the flushing is atypical or not clearly associated with a benign underlying process. Read More

    Personalised immunomodulating treatments for Graves' disease: fact or fiction?
    Swiss Med Wkly 2017 Aug 14;147:w14476. Epub 2017 Aug 14.
    Medical University Department, Clinic for Medical University Department, Clinic for Endocrinology, Diabetes and Metabolism, Kantonsspital Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
    Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency. Read More

    The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats.
    Horm Mol Biol Clin Investig 2017 Aug 10. Epub 2017 Aug 10.
    Background Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Read More

    Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice.
    Biomed Res Int 2017 16;2017:6071031. Epub 2017 Jul 16.
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
    Persistent cardiovascular pathology has been described in hyperthyroid patients even with effective antithyroid treatment. Here, we studied the effect of a well-known antithyroid drug, propylthiouracil (PTU; 20 mg/kg/day), on thyroxine (T4; 500 µg/kg/day)-induced increase in blood pressure (BP), cardiac hypertrophy, and altered responses of the contractile myocardium both in vivo and ex vivo after 2 weeks of treatment. Furthermore, the potential recovery through 2 weeks of T4 treatment discontinuation was also investigated. Read More

    Tremelimumab-Induced Graves Hyperthyroidism.
    Eur Thyroid J 2017 Jul 14;6(3):167-170. Epub 2017 Mar 14.
    Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom.
    Tremelimumab and ipilimumab are monoclonal antibodies directed against the extracellular domain of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and have been used as immunotherapies against immune checkpoints that suppress T-cell activation. Anti-CTLA-4 antibody-based therapies have been shown to be effective in treating various cancers including metastatic melanoma. However, a few immune-related adverse events including hypophysitis and thyroid disorder have been reported, mostly developed within the first year of receiving treatment. Read More

    Survey of Clinical Practice Patterns in the Management of 992 Hyperthyroid Patients in France.
    Eur Thyroid J 2017 Jul 5;6(3):152-159. Epub 2017 Jan 5.
    Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey, Université Paul Sabatier, Toulouse, France.
    Background: Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries.

    Methods: A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Read More

    Metabolomic profile in hyperthyroid patients before and after antithyroid drug treatment: Correlation with thyroid hormone and TSH concentration.
    Int J Biochem Cell Biol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy.
    Hyperthyroidism (HT) is characterized by an intense metabolic impact which affects the lipid, carbohydrate and amino acids metabolism, with increased resting energy expenditure and thermogenesis. Metabolomics is a new comprehensive technique that allows to capture an instant metabolic picture of an organism, reflecting peculiar molecular and pathophysiological states. The aim of the present prospective study was to identify a distinct metabolomic profile in HT patients using (1)H NMR spectroscopy before and after antithyroid drug treatment. Read More

    An acute phase reaction with intravenous bisphosphonate use in a patient with recently diagnosed Graves' disease.
    Clin Case Rep 2017 Aug 19;5(8):1226-1229. Epub 2017 Jun 19.
    Macarthur Diabetes and Endocrine CentreCampbelltown HospitalCampbelltownNew South WalesAustralia.
    Given the immune background, we hypothesize that active Grave's hyperthyroidism is a risk factor for an acute phase reaction associated with the use of bisphosphonates. We recommend that in patients with Graves' thyrotoxicosis and hypercalcemia, consider the risk of an acute phase reaction if planning to give bisphosphonate therapy. Read More

    Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring.
    Biomed Rep 2017 Aug 21;7(2):183-187. Epub 2017 Jun 21.
    Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210012, P.R. China.
    Hyperthyroidism causes impaired glucose tolerance, insulin resistance (IR) and insulin secretion. However, the glucose variability affected by thyroid dysfunction remains unclear. Glucose variability was assessed by continuous glucose monitoring (CGM) in a non-diabetic patient with Graves' disease (GD), to the best of our knowledge, for the first time. Read More

    Takotsubo Myocardiopathy and Hyperthyroidism: A Case Report and Literature Review.
    Am J Case Rep 2017 Aug 7;18:865-870. Epub 2017 Aug 7.
    Department of Internal Medicine, Hospital de Clínicas "Jose de San Martin", University of Buenos Aires, Buenos Aires, Argentina.
    BACKGROUND Takotsubo cardiomyopathy (TM), also called stress myocardiopathy or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction with reversible wall motion abnormalities. TM resembles acute coronary syndrome (ACS) in the absence of coronary artery disease (CAD). In several reports, TM has been described in association with hyperthyroidism, suggesting the potential role of thyrotoxicosis in the pathophysiology. Read More

    Familial Dysalbuminemic Hyperthyroxinemia that was Inappropriately Treated with Thiamazole Due to Pseudo-thyrotoxic Symptoms.
    Intern Med 2017 Aug 1;56(16):2175-2180. Epub 2017 Aug 1.
    Division of Endocrinology and Diabetology, Ohme Municipal General Hospital, Japan.
    We herein report the case of a Japanese woman with familial dysalbuminemic hyperthyroxinemia (FDH) who was initially diagnosed with Graves' disease. Direct genomic sequencing revealed a guanine to cytosine transition in the second nucleotide of codon 218 in exon 7 of the albumin gene, which then caused a proline to arginine substitution. She was finally diagnosed with FDH, which did not require treatment. Read More

    Typical graves' ophthalmopathy in primary hypothyroidism.
    J Pak Med Assoc 2017 Jul;67(7):1104-1106
    Aga Khan University Hospital, Karachi, Pakistan.
    Graves ophthalmopathy (GO) usually occurs in a close temporal relationship with hyperthyroidism. It is rare in patients with normal thyroid function (euthyroid GO) and in patients with hypothyroid forms of thyroid autoimmune diseases (hypothyroid GO). We report a 52-years old man presenting in our endocrine clinic with diagnosed primary hypothyroidism 3 months back during evaluation for glaucoma. Read More

    Thyrotoxicosis Presenting as Unilateral Drop Foot.
    Intern Med 2017 1;56(15):2053-2056. Epub 2017 Aug 1.
    Department of Neurology, Akita Red Cross Hospital, Japan.
    Neuromuscular disorders associated with hyperthyroidism have several variations in their clinical phenotype, such as ophthalmopathy, periodic paralysis, and thyrotoxic myopathy. We herein report an unusual case of thyrotoxic myopathy presenting as unilateral drop foot. Histopathological examinations of the left tibialis anterior muscle showed marked variation in the fiber size, mild inflammatory cell infiltration, and necrotic and regenerated muscle fibers with predominantly type 1 fiber atrophy. Read More

    Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence.
    Medicine (Baltimore) 2017 Aug;96(31):e7700
    Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
    Graves disease is the most common cause of thyrotoxicosis. Although medical intervention with antithyroid drugs (ATDs) is commonly the first choice of treatment in Korea, the remission rate associated with this approach is not satisfactory. During ATD therapy, low or undetectable serum levels of thyroid-stimulating hormone (TSH) receptor antibodies (TRAbs) have been reported to affect the incidence of Graves disease remission. Read More

    Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats.
    Biomed Pharmacother 2017 Jul 28;94:124-128. Epub 2017 Jul 28.
    II Department of Radiology, Medical University in Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
    Physiological concentrations of thyroid hormones are crucial for skeletal growth and development, physiological bone turnover and bone homeostasis maintenance. Methimazole (1-methyl-2-mercaptoimidazole) is an antithyroid drug used for the treatment of the hyperthyroidism in humans and animals. The aim of the study was to determine effects of long-term oral methimazole treatment in male Wistar rats on biochemical bone metabolism markers, as well as morphological, geometric, densitometric and mechanical properties of femur and tibia. Read More

    Thyroid Medication Use and Birth Defects in the National Birth Defects Prevention Study.
    Birth Defects Res 2017 Jul 31. Epub 2017 Jul 31.
    Congenital Malformations Registry, New York State Department of Health, Albany, New York.
    Background: Thyroid disorders are common among reproductive-aged women, with hypothyroidism affecting 2 to 3% of pregnancies, and hyperthyroidism affecting an additional 0.1 to 1%. We examined associations between thyroid medications and individual birth defects using data from the National Birth Defects Prevention Study (NBDPS). Read More

    Raising Awareness of Graves' Orbitopathy with Early Warning Cards.
    Clin Endocrinol (Oxf) 2017 Jul 29. Epub 2017 Jul 29.
    Thyroid Research Group, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.
    Background: Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and establishing a fast-track referral pathway to specialist care should overcome these delays and potentially improve outcomes. Read More

    Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.
    Res Vet Sci 2017 Jul 24;115:412-417. Epub 2017 Jul 24.
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
    Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment. Initially non-azotaemic hyperthyroid cats and healthy older cats were included. Serum concentrations of protein fractions were determined by agarose gel electrophoresis and compared between; hyperthyroid and control cats, initially non-azotaemic hyperthyroid cats which developed azotaemia in a 4month follow up period (masked-azotaemic) and those which remained non-azotaemic, and hyperthyroid cats before and at the time of restoration of euthyroidism. Read More

    Hyperthyroidism in Patients with Graves' Ophthalmopathy, and Thyroidal, Skeletal and Eye Muscle Specific Type 2 Deiodinase Enzyme Activities.
    Exp Clin Endocrinol Diabetes 2017 Jul 27. Epub 2017 Jul 27.
    Immunoendocrinology and Osteoporosis Centre, EndoMed, Bem tér 18/C., Debrecen, Hungary.
    Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T3 levels than T4 due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with (125)I-T4 substrate, while thyroid hormone and antibody levels with immunoassays. Read More

    [Clinical features of patients with Basedow Graves disease seen at a university hospital].
    Rev Med Chil 2017 Apr;145(4):436-440
    Sección Endocrinología y Diabetes, Hospital Clínico, Universidad de Chile, Santiago, Chile.
    Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population.

    Aim: To describe the clinical features of patients with BGD seen at a university hospital. Read More

    The Association of Autoimmune Thyroid Disease (AITD) with Psoriatic Disease: a prospective cohort study, systematic review and meta-analysis.
    Eur J Endocrinol 2017 Jul 26. Epub 2017 Jul 26.
    L Chaker, Epidemiology, Erasmus MC, Rotterdam, Netherlands.
    Objective Autoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results. Design We assessed the association of AITD with psoriatic disease in a prospective cohort study, and performed a systematic review and meta-analysis. Read More

    Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report.
    Medicine (Baltimore) 2017 Jul;96(30):e7591
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
    Rationale: Myalgia and elevated creatine kinase (CK) are occasionally observed during the treatment of hyperthyroid patients. Relative hypothyroidism resulted from rapid thyroid hormone reduction had been promoted as a plausible cause of these myopathic changes, however rarely reported.

    Patient Concerns: We hereby presented a 20-year-old female with Grave's disease, who developed myopathy and elevated CK during rapid correction of thyroid hormone. Read More

    18F-FDG PET/CT imaging of atypical subacute thyroiditis in thyrotoxicosis: A case report.
    Medicine (Baltimore) 2017 Jul;96(30):e7535
    aPET Imaging Center, Asahi General Hospital bDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba cDepartment of Diagnostic Radiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo dDepartment of Radiology, Asahi General Hospital, Chiba, Japan.
    Background: In addition to its established role in oncologic imaging, F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is useful for the assessment of inflammatory activity. However, subacute thyroiditis (SAT) in thyrotoxicosis is rarely detected during these scans.

    Case: A 66-year-old man with SAT in thyrotoxicosis demonstrated symptoms of transient fatigue, headache, and fever, without typical neck pain. Read More

    Thyroid Disorders in Central Ghana: The Influence of 20 Years of Iodization.
    J Thyroid Res 2017 4;2017:7843972. Epub 2017 Jul 4.
    Komfo Anokye Teaching Hospital, Kumasi, Ghana.
    Background: Ghana began mandatory iodization of salt in 1996. This study compares the prevalence of thyroid disorders before and after the introduction of iodization.

    Methods: This is a retrospective study of thyroid cases from the middle belt of Ghana between 1982 and 2014. Read More

    Hyperthyroidism and the Heart.
    Methodist Debakey Cardiovasc J 2017 Apr-Jun;13(2):60-63
    Houston Methodist Hospital, Houston, Texas.
    Thyroid hormones have a significant impact on cardiac function and structure. Excess thyroid hormone affects cardiovascular hemodynamics, leading to high-output heart failure and, in late stages, dilated cardiomyopathy. In this review, we discuss how hyperthyroidism affects cardiovascular pathophysiology and molecular mechanisms and examine the complications caused by excess thyroid hormone, such as heart failure and atrial fibrillation. Read More

    Comparison of three competitive immunoassays for measurement of TSH receptor antibodies in patients with Graves' disease.
    Scand J Clin Lab Invest 2017 Jul 24:1-6. Epub 2017 Jul 24.
    a Department of Clinical Biochemistry , Aalborg University Hospital , Aalborg , Denmark.
    Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD). The aim of the study was to compare the diagnostic performance and assay agreement between three immunoassays for the measurement of TRAb in patients with newly diagnosed GD. TRAb was measured with three different assays [H-TRAb (BRAHMS Diagnostica), M22-Man (RSR Limited) and M22-Aut (Roche Diagnostics)] in 387 participants who were recruited from two Danish population-based studies and diagnosed with GD (n = 101), multinodular toxic goitre (n = 88), primary autoimmune hypothyroidism (n = 100) or included as controls (n = 98). Read More

    Standard-dose pembrolizumab in combination with reduced-dose ipilimumab for patients with advanced melanoma (KEYNOTE-029): an open-label, phase 1b trial.
    Lancet Oncol 2017 Jul 17. Epub 2017 Jul 17.
    Westmead Hospital, Westmead, NSW, Australia; Melanoma Institute Australia, University of Sydney, Sydney, NSW, Australia; Blacktown Hospital, Blacktown, NSW, Australia.
    Background: Reduced-dose nivolumab in combination with standard-dose ipilimumab improves objective response and progression-free survival compared with standard-dose ipilimumab alone, but increases toxicity. We assessed the safety and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimumab.

    Methods: In this open-label, phase 1b trial, we recruited patients from 12 medical centres in Australia, New Zealand, and the USA. Read More

    Single-Session High-Intensity Focused Ultrasound Treatment for Persistent or Relapsed Graves Disease: Preliminary Experience in a Prospective Study.
    Radiology 2017 Jul 20:162776. Epub 2017 Jul 20.
    From the Departments of Surgery (B.H.H.L.), Medicine (Y.C.W.), Ophthalmology (I.Y.H.W.), and Radiology (K.W.H.C.), The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong Special Administrative Region, China.
    Purpose To evaluate the safety and efficacy of ultrasonography (US)-guided high-intensity focused ultrasound (HIFU) ablation as a treatment for medically refractory Graves disease (GD). Materials and Methods After ethics approval, a prospective trial (NCT02685514) was performed from November 2015 to February 2016. Thirty patients underwent ablation of the entire right and left thyroid lobes, with areas near the tracheal-esophageal groove and common carotid artery left unablated. Read More

    Autoimmune hypothyroidism is three times more frequent in female prolactinoma patients compared to healthy women: data from a cross-sectional case-control study.
    Endocrine 2017 Jul 19. Epub 2017 Jul 19.
    University Hospital of Endocrinology, Sofia, Bulgaria.
    Background: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population.

    Purpose: A cross-sectional case-control study was carried out in a single tertiary referral centre. Read More

    Thyrotoxic Valvulopathy: Case Report and Review of the Literature.
    Cardiol Res 2017 Jun 30;8(3):134-138. Epub 2017 Jun 30.
    Division of Cardiology, University of South Alabama, Mobile, AL 36617, USA.
    We report a 42-year-old female who was admitted for abdominal pain, and also endorsed dyspnea, fatigue and chronic palpitations. Past medical history included asthma, patent ductus arteriosus repaired in childhood and ill-defined thyroid disease. Physical examination revealed blood pressure of 136/88 mm Hg and heart rate of 149 beats per minute. Read More

    Iodine concentration calculated by dual-energy computed tomography (DECT) as a functional parameter to evaluate thyroid metabolism in patients with hyperthyroidism.
    BMC Med Imaging 2017 Jul 19;17(1):43. Epub 2017 Jul 19.
    Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Faculty of Medicine, 3-39-22, Showa, Maebashi, Gunma, 371-8511, Japan.
    Background: Thyroid function in patients with Grave's disease is usually evaluated by thyroid scintigraphy with radioactive iodine. Recently, dual-energy computed tomography (DECT) with two different energy X-rays can calculate iodine concentrations and can be applied for iodine measurements in thyroid glands. This study aimed to assess the potential use of DECT for the functional assessment of the thyroid gland. Read More

    [Evaluation and management of hyperhidrosis].
    Rev Med Suisse 2017 Mar;13(556):710-714
    Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.
    Hyperhidrosis is excessive sweating beyond what is expected for thermoregulatory needs. Nearly 3 % of the population has hyperhidrosis. It may be primary or secondary to medications or general medical conditions, including diabetes mellitus, hyperthyroidism, Parkinson disease, etc. Read More

    An FSH and TSH pituitary adenoma, presenting with precocious puberty and central hyperthyroidism.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jul 7.
    Endocrinology Service and Experimental Endocrinology Unit, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico CityMexico.
    A 19-year-old woman with a history of isosexual precocious puberty and bilateral oophorectomy at age 10 years because of giant ovarian cysts, presents with headaches and mild symptoms and signs of hyperthyroidism. Hormonal evaluation revealed elevated FSH and LH levels in the postmenopausal range and free hyperthyroxinemia with an inappropriately normal TSH. Pituitary MRI showed a 2-cm macroadenoma with suprasellar extension. Read More

    The thyroid gland in postmenopausal women: physiology and diseases.
    Prz Menopauzalny 2017 Jun 30;16(2):33-37. Epub 2017 Jun 30.
    Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland.
    The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Read More

    Clinical outcomes 1 year after empiric 131I therapy for hyperthyroid disorders: real life experience and predictive factors of functional response.
    Nucl Med Commun 2017 Sep;38(9):756-763
    aNuclear Medicine Department, Institut Universitaire de Cancérologie Oncopole, Institut Claudius Regaud bFaculty of Medicine, Paul Sabatier University cNuclear Medicine Department dEndocrinology Department, Larrey Hospital, University Hospitals of Toulouse eCancer Research Center of Toulouse, Paul Sabatier University, Toulouse, France.
    Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG).

    Purpose: To compare empiric and calculated I activities using 2013 EANM recommendations. To look for predictive factors of therapeutic response to an empiric activity of I. Read More

    Increased risk for thionamide-induced agranulocytosis in elderly patients: a case presentation and literature review.
    BMJ Case Rep 2017 Jul 17;2017. Epub 2017 Jul 17.
    Department of Endocrinology, St Francis Medical Center, Seton Hall University, Trenton, New Jersey, USA.
    Thionamides, such as methimazole and propylthiouracil, are used for the management of hyperthyroidism. Agranulocytosis is a rare adverse effect of thionamides and elderly patients are especially vulnerable. Here we discuss a case of an 80-year-old woman who developed agranulocytosis and pneumonia approximately 4 weeks after starting low dose methimazole therapy. Read More

    Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance.
    Front Endocrinol (Lausanne) 2017 30;8:137. Epub 2017 Jun 30.
    Unit of Endocrinology, Department of Medicine and Sciences of Aging, Ce.S.I.-Me.T., University of Chieti-Pescara, Chieti, Italy.
    Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. Read More

    Systemic lupus erythematosus and thyroid disease - Experience in a single medical center in Taiwan.
    J Microbiol Immunol Infect 2017 Jun 28. Epub 2017 Jun 28.
    Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: To investigate the association of systemic lupus erythematosus (SLE) with thyroid diseases in a medical center in central Taiwan.

    Methods: This is a retrospective cohort of 2796 SLE patients in a tertiary referral medical center from 2000 to 2013. We screened SLE by catastrophic illness registration from national insurance bureau; and thyroid diseases by ICD 9 codes, then confirmed by thyroid function test, auto-antibody, medical and/or surgical intervention. Read More

    [Manifestations of autoimmune disorders in otorhinolaryngology : Classical symptoms and diagnostic approach].
    HNO 2017 Aug;65(8):695-708
    Hals-Nasen-Ohren-Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675, München, Deutschland.
    Manifestations of autoimmune disorders represent a diagnostic challenge. Many autoimmune disorders show typical manifestations in the ear, nose and throat and should be taken into account in the differential diagnosis. Sjogren's syndrome, various vasculitides and sarcoidosis represent the most common autoimmune disorders in otorhinolaryngology, but IgG4-related diseases, relapsing polychondritis and autoimmune disorders of the mucosa are also observed. Read More

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