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    Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis.
    J Endocrinol Invest 2017 May 22. Epub 2017 May 22.
    Endocrinology Department, Cesar Milstein Hospital, 951 La Rioja St, 1221, Buenos Aires, Argentina.
    Purpose: Overt hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients. Read More

    Antithyroid Drug Therapy for Graves' Disease and Implications for Recurrence.
    Int J Endocrinol 2017 25;2017:3813540. Epub 2017 Apr 25.
    Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
    Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. Read More

    Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats.
    Endocrine 2017 May 19. Epub 2017 May 19.
    Laboratory of Endocrine Physiology, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Purpose: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Read More

    Left ventricular mural thrombus and dual coronary embolization associated with hyperthyroid cardiomyopathy and atrial fibrillation: a case report.
    BMC Cardiovasc Disord 2017 May 19;17(1):128. Epub 2017 May 19.
    Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, 130000, China.
    Background: The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid-related cardiomyopathy and atrial fibrillation. Read More

    Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
    Lancet Gastroenterol Hepatol 2017 May 15. Epub 2017 May 15.
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands. Electronic address:
    Background: Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. Read More

    Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study).
    BMC Musculoskelet Disord 2017 May 18;18(1):201. Epub 2017 May 18.
    Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.
    Background: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis.

    Methods: In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis.

    Results: Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15. Read More

    Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis.
    J Endocrinol Invest 2017 May 17. Epub 2017 May 17.
    Department of Endocrinology, Gansu Provincial Hospital, Dong gang West Road, Lanzhou, 730000, Gansu, People's Republic of China.
    Purpose: To investigate the relationship between hypothyroidism, hyperthyroidism, thyroid hormone replacement, and the risk of breast cancer.

    Methods: We searched the PubMed, Cochrane Library, EMbase, Web of Science, and China Biology Medicine (CBM) databases through June 2016 to identify researches that assessed the relationship between thyroid dysfunction and the risk of breast cancer together with the impact of thyroid hormone substitution treatment on incidence of breast cancer. Quality of evidence was assessed per outcome, using GRADE. Read More

    Autoimmune Voltage-Gated Potassium Channelopathy Presenting With Catecholamine Excess.
    Pediatr Neurol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Pediatrics, Maine Medical Center's Barbara Bush Children's Hospital, Portland, Maine.
    Background: Autoimmune voltage-gated potassium channelopathies have been associated with a range of neurological presenting symptoms, including central, peripheral, and autonomic dysfunction.

    Patient Description: We describe a 12-year-old boy who presented with nine months of pain, anxiety, and 30-pound weight loss. He was admitted for failure to thrive, then noted to be persistently hypertensive and tachycardic. Read More

    Antithyroid drug-associated MPO-ANCA-positive tubulointerstitial nephritis in a type 2 diabetes patient: a case report.
    CEN Case Rep 2017 May 3;6(1):22-28. Epub 2016 Oct 3.
    Department of Internal Medicine, Okayama Saiseikai General Hospital, 2-25 Kokutai-cho, Kita-Ward, Okayama, Okayama, 700-8511, Japan.
    A 54-year-old man diagnosed with type 2 diabetes and hyperthyroidism was prescribed propylthiouracil (PTU) after the patient developed hepatic dysfunction on thiamazole. At 50 mg/day of PTU, he was stable with thyroid-stimulating hormone receptor and thyrotropic antibody titers remaining stable. After four years of taking PTU, he was referred to the Department of Nephrology due to a rapid increase in his serum creatinine (Cr) level. Read More

    Fetal recurrent thyrotoxicosis.
    Ultrasound Obstet Gynecol 2017 May 15. Epub 2017 May 15.
    Maternal Fetal Medicine Unit. Department of Obstetrics. University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Fetal hyperthyroidism is a rare and potentially life-threatening condition, not always easy to detect(1,2) . It is most commonly observed in maternal thyroid autoimmune disorders such as poorly controlled Grave's disease. Transplacental passage of maternal thyroid stimulating immunoglobulins (TSI) is the main cause of fetal thyroid gland stimulation and the clinical manifestations of this disorder: intrauterine growth restriction, non-immune hydrops, fetal goiter, tachycardia, craniosynostosis, accelerate bone maturation and intrauterine death(2) . Read More

    Stiff-Person Syndrome and Graves' Disease: A Pediatric Case Report.
    Child Neurol Open 2016 Jan-Dec;3:2329048X16684397. Epub 2016 Dec 15.
    Department of Neurology, Hospital Santa Marcelina, São Paulo, Brazil.
    A 9-year-old female child presented with a history of falls, weight loss, diffuse leg pain, and progressive gait disorder, following 1 previous event described as a tonic-clonic seizure. She had increased thyroid volume, brisk symmetric reflexes, abnormal gait, and painful spasms of the paraspinal musculature. Thyroid function tests indicated biochemical hyperthyroidism, and thyrotropin receptor antibodies were positive. Read More

    Thyroid Dysfunctions in a Sample of Egyptian Children and Adolescents with Systemic Lupus Erythematosus: Relation to Disease Activity and Duration.
    Egypt J Immunol 2016 Jun;23(2):65-73
    Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. Read More

    Temporal trends for thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (ATPO) testing across two phases of iodine fortification in tasmania (1995-2013).
    Clin Endocrinol (Oxf) 2017 May 13. Epub 2017 May 13.
    Department of Diabetes & Endocrinology, Royal Hobart Hospital.
    Context: Tasmania is an island State of the Australian Commonwealth with a well-documented history of mild iodine deficiency. Between 2001 and 2009 Tasmania experienced two incremental phases of iodine fortification.

    Objective: To examine trends for thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (ATPO) testing and their relationship to different phases of iodine nutrition in the Tasmanian population between 1995 and 2013. Read More

    Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism.
    Int Med Case Rep J 2017 2;10:149-152. Epub 2017 May 2.
    Dermatology Department.
    Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported. Read More

    Life-threatening haematological complication occurring in a cat after chronic carbimazole administration.
    JFMS Open Rep 2016 Jul-Dec;2(2):2055116916668198. Epub 2016 Sep 30.
    Medivet Ltd, Watford, UK.
    Case Summary: An 11-year-old spayed female domestic shorthair cat with a history of hyperthyroidism treated with carbimazole for 7 months was presented for a check-up after a few episodes of vomiting. The cat had been receiving prednisolone at 0.5 mg/kg PO q12h for recent pancreatitis and concurrent inflammation of liver and small intestines confirmed by biopsies. Read More

    Thyroid Function during Early Life and Dental Development.
    J Dent Res 2017 May 1:22034517708551. Epub 2017 May 1.
    1 The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, the Netherlands.
    Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age. Read More

    Rare NOX3 Variants Confer Susceptibility to Agranulocytosis during Thyrostatic Treatment of Graves' Disease.
    Clin Pharmacol Ther 2017 May 9. Epub 2017 May 9.
    Department of Internal Medicine, Division of Endocrinology.
    Agranulocytosis is a rare and serious adverse effect of antithyroid drugs, with unknown etiology. The present study aimed to uncover genetic susceptibility and underlying mechanisms of antithyroid drug-induced agranulocytosis (ATDAC). We studied two independent families with familial Graves' disease, of which several members developed ATDAC. Read More

    Influence of screening and intervention of hyperthyroidism on pregnancy outcome.
    Eur Rev Med Pharmacol Sci 2017 Apr;21(8):1932-1937
    Department of Galactophore Surgery, Weifang People's Hospital, Weifang, China.
    Objective: To discuss the influence of screening and intervention of hyperthyroidism on pregnancy outcome.

    Patients And Methods: The clinical data of 122 pregnant women who had been confirmed with hyperthyroidism from April 2012 to July 2014 in the Weifang People's Hospital were analyzed retrospectively (25 untreated, 97 treated). 60 with normal pregnancy check were randomly selected as control group. Read More

    Thyroid states regulate subcellular glucose phosphorylation activity in male mice.
    Endocr Connect 2017 May 8. Epub 2017 May 8.
    W da-Silva, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil
    The thyroid hormones (THs), triiodothyronine (T3) and thyroxine (T4), are very important in organism metabolism and regulate glucose utilization. Hexokinase (HK) is responsible for the first step of glycolysis, catalyzing the conversion of glucose to glucose 6-phosphate. HK has been found in different cellular compartments, and new functions have been attributed to this enzyme. Read More

    Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts.
    J Clin Endocrinol Metab 2017 May 5. Epub 2017 May 5.
    Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
    Context: Hyperthyroidism is associated with increased fracture risk, but it is not clear if lower TSH and higher free thyroxine (FT4) in euthyroid individuals are associated with fracture risk.

    Objective: To evaluate the association of TSH and FT4 with incident fractures in euthyroid individuals.

    Design: Individual participant data analysis. Read More

    Georgian Med News 2017 Mar(264):21-25
    "David Gagua Clinic" Ltd., Tbilisi, Georgia.
    Maternal thyroid pathology takes important role in obstetric and peri-neonatal morbidity structure. Despite of the number of studies conducted in the field of thyroid disorders of pregnant females, the definition of influence of thyroid gland dysfunction on maternal and neonatal health still remains actual. The mentioned topics draw specific interest in the aspect of prognosticaiton of complications and unfavorable outcome. Read More

    Epidemiology, management and outcomes of Graves' disease-real life data.
    Endocrine 2017 Jun 6;56(3):568-578. Epub 2017 May 6.
    Endocrine Surgery Unit, Directorate of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Purpose: Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surgery in Graves' disease. Read More

    Thyroid dysfunction and autoimmune thyroid diseases among atomic-bomb survivors exposed in childhood.
    J Clin Endocrinol Metab 2017 May 1. Epub 2017 May 1.
    Department of Clinical Studies (Drs Imaizumi, Ohishi, Sera, Yamada, Tatsukawa, Takahashi, Akahoshi, Hida), and Department of Statistics (Dr. Nakashima), Radiation Effects Research Foundation; Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital (Dr. Sera); Yachiyo Hospital (Dr. Neriishi); Hiroshima Atomic Bomb Casualty Council (Dr. Fujiwara); Nakajima Tsuchiya Clinic (Dr. Sugino); Keiju Hospital (Dr. Akahoshi), First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University (Drs Imaizumi, Ando, Kawakami); International Hibakusha Medical center, Nagasaki University Hospital (Dr. Usa).
    Context: The risk of thyroid cancer increases and persists for decades among individuals exposed to ionizing radiation in childhood, while long-term effects of childhood exposure to medium to low doses radiation on thyroid dysfunction and autoimmune thyroid diseases have remained unclear.

    Objective: To evaluate radiation-dose responses for the prevalence of thyroid dysfunction and autoimmune thyroid disease among atomic -bomb survivors exposed in childhood.

    Design, Setting, And Participants: Hiroshima and Nagasaki atomic-bomb survivors who were younger than 10 years old at exposure underwent thyroid examinations at the Radiation Effects Research Foundation between 2007 and 2011, which was 62-66 years after the bombing. Read More

    Clinical characteristics of moderate-to-severe thyroid associated ophthalmopathy in 354 Chinese cases.
    PLoS One 2017 4;12(5):e0176064. Epub 2017 May 4.
    Zhongshan Ophthalmic Center, State Key laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.
    Thyroid associated ophthalmopathy (TAO) is an autoimmune inflammatory disorder which disfigures appearance, threatens vision, and results in a pronounced loss of quality of life. The diversity and ethnic difference of the disease manifestations have made it difficult to tailor therapies for each patient. Few studies have analyzed its characteristics in Chinese populations. Read More

    Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
    Thyroid 2017 May 4. Epub 2017 May 4.
    Karolinska Institutet, Institution for Clinical Science and Education , Sjukhusbacken 10 , Stockholm, Sweden , 11883 ;
    Background Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogenous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. Read More

    The Role of Thyrotropin Receptor Activation in Adipogenesis and Modulation of Fat Phenotype.
    Front Endocrinol (Lausanne) 2017 19;8:83. Epub 2017 Apr 19.
    Thyroid Research Group, Cardiff University, Cardiff, UK.
    Evidence from clinical and experimental data suggests that thyrotropin receptor (TSHR) signaling is involved in energy expenditure through its impact on white adipose tissue (WAT) and brown adipose tissue (BAT). TSHR expression increases during mesenchymal stem cell (MSC) differentiation into fat. We hypothesize that TSHR activation [TSHR*, elevated thyroid-stimulating hormone, thyroid-stimulating antibodies (TSAB), or activating mutation] influences MSC differentiation, which contributes to body composition changes seen in hypothyroidism or Graves' disease (GD). Read More

    Association of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) with Hyperthyroidism in Domestic Felines, Sentinels for Thyroid Hormone Disruption.
    BMC Vet Res 2017 May 3;13(1):120. Epub 2017 May 3.
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Dr., Davis, CA, 95616, USA.
    Background: Hyperthyroidism is the most common endocrine disorder observed in domestic felines; however, its etiology is largely unknown. Two classes of persistent organic pollutants, polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known to interfere with thyroid hormone (TH) signaling and regulation; thus, it is postulated that they contribute to the etiopathogenesis of feline hyperthyroidism and pose a risk to humans and other species. In this case-control study, the concentrations of 13 PBDE and 11 PCB congeners were measured by gas chromatography mass spectrometry in serum or plasma samples from 20 hyperthyroid and 31 control cats in order to investigate the association between concentration of PBDE and PCB congeners and feline hyperthyroidism. Read More

    Teprotumumab for Thyroid-Associated Ophthalmopathy.
    N Engl J Med 2017 05;376(18):1748-1761
    From the Department of Ophthalmology and Visual Sciences, Kellogg Eye Center (T.J.S., R.S.D.), and the Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine (T.J.S.), University of Michigan Medical School, Ann Arbor; the Department of Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany (G.J.K.); Moorfields Eye Hospital, London (D.G.E.); the University of Tennessee Health Science Center, Memphis (J.C.F.); the Oculofacial Plastic Surgery Division, Oregon Health and Science University, Portland (R.A.D.); Eye Wellness Center, Neuro-Ophthalmology of Texas, Houston (R.A.T.); the Department of Ophthalmology, Medical College of Wisconsin, Milwaukee (G.J.H.); the Department of Clinical and Experimental Medicine, University of Pisa, Pisa (A.A.), and the Endocrinology and Diabetology Unit, Fondazione IRCCS Ca' Granda, University of Milan, Milan (M.S.) - both in Italy; the Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles (R.A.G.); the University of Nebraska Medical Center, Omaha (J.W.G.); Barnes-Jewish Hospital, Washington University, St. Louis (S.M.C.); the Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City (E.M.S.); the Department of Ophthalmology, Emory University, Atlanta (B.R.H.); the Department of Ophthalmology, University of Colorado, Aurora (E.M.H.); and River Vision Development, New York (R.M.W., K.G., G.M.).
    Background: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. Read More

    A Rare Complication following Thyroid Percutaneous Ethanol Injection: Plummer Adenoma.
    Case Rep Endocrinol 2017 29;2017:1026139. Epub 2017 Mar 29.
    Department of Endocrinology, University Campus Bio-Medico, Rome, Italy.
    Percutaneous ethanol injection (PEI) is a technique used only for benign thyroid nodules, cystic or mixed cystic-solid with a large fluid component. It is a quite low-cost, safe, and outpatient method of treatment. Rare and severe complications have been described after PEI: jugular vein thrombosis and severe ethanol toxic necrosis of the larynx combined with necrotic dermatitis. Read More

    Takotsubo cardiomyopathy in amiodarone-induced hyperthyroidism.
    Endocrinol Diabetes Metab Case Rep 2017 15;2017. Epub 2017 Feb 15.
    Endocrinology Department, Parc Taulí Sabadell University Hospital, Sabadell Barcelona, Spain.
    Summary: Takotsubo cardiomyopathy (TC) is an atypical, severe but reversible form of acute heart insufficiency. It typically presents with left ventricular failure, transient apical and mid-segments hypokinesis, absence of significant coronary stenosis and new electrographic abnormalities and/or elevation in serum cardiac enzymes. Although TC ('broken heart syndrome') has classically been associated with emotional trauma, evidence suggests that other precipitants might exist, including iatrogenic and thyroid-mediated forms. Read More

    Successful treatment of thyroid storm presenting as recurrent cardiac arrest and subsequent multiorgan failure by continuous renal replacement therapy.
    Endocrinol Diabetes Metab Case Rep 2017 31;2017. Epub 2017 Mar 31.
    Division of Nephrology, Kosin University College of Medicine, BusanRepublic of Korea.
    Summary: Thyroid storm is a rare and potentially life-threatening medical emergency. We experienced a case of thyroid storm associated with sepsis caused by pneumonia, which had a catastrophic course including recurrent cardiac arrest and subsequent multiple organ failure (MOF). A 22-year-old female patient with a 10-year history of Graves' disease was transferred to our emergency department (ED). Read More

    Is herbal therapy safe in obesity? A case of Apium graveolens (Celery) induced hyperthyroidism.
    ARYA Atheroscler 2016 Sep;12(5):248-249
    Internist, Associate Professor, Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Background: Apium graveolens is one of the well-known herbs used for the treatment of different; however, allergic reactions have been reported after its use. This report aimed to demonstrate the A. graveolens induced hyperthyroidism after its oral consumption for weight loss. Read More

    Changes in hepatic TRβ protein expression, lipogenic gene expression, and long chain acylcarnitine levels during chronic hyperthyroidism and T3 withdrawal in a mouse model.
    Thyroid 2017 Apr 29. Epub 2017 Apr 29.
    Duke-NUS Graduate Medical School, Cardiovascular and Metabolism Program , 8 College Road, Level 8 , Singapore, Singapore , 169857 ;
    Background: Thyroid hormone (TH) has important roles in regulating hepatic metabolism. We previously reported that most hepatic genes activated by a single T3 injection became desensitized after multiple injections, and that approximately 10% of target genes did not return to basal expression levels after T3 withdrawal despite normalization of serum TH and TSH levels. To determine the possible mechanism(s) for desensitization and incomplete recovery of hepatic target gene transcription and their effects on metabolism, we measured mRNA and/or protein expression levels of key regulators of TH action as well as metabolomic changes after chronic T3 treatment and withdrawal. Read More

    Thyroid disorders and mammographic density in Spanish women: Var-DDM study.
    Breast 2017 Apr 26;34:12-17. Epub 2017 Apr 26.
    Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain. Electronic address:
    Objectives: The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women. Read More

    GLP-1 and GIP Levels in Patients With Hyperthyroidism: The Effect of Antithyroid Treatment.
    Ann Pharmacother 2017 Apr 1:1060028017707221. Epub 2017 Apr 1.
    1 Akdeniz University, School of Medicine, Antalya, Turkey.
    Background: Incretin hormones (glucagon-like peptide-1 [GLP-1] and gastric inhibitory polypeptide [GIP]) may play a role in the development of glucose intolerance and hyperglycemia in patients with hyperthyroidism.

    Objective: We aimed to assess both incretin levels and treatment-induced changes in incretin levels in those with hyperthyroidism.

    Methods: A total of 24 subjects (12 with hyperthyroidism and 12 healthy) were enrolled in the study. Read More

    [Student abuse and Graves-basedow's disease: about a case].
    Pan Afr Med J 2017 12;26:15. Epub 2017 Jan 12.
    Service d'Endocrinologie du Centre Hospitalier Universitaire de Libreville, Libreville, Gabon.
    Graves-basedow's disease is an autoimmune thyreopathy which represents the most common cause of hyperthyroidism in both adults and children. This disease would be related to a genetic predisposition influenced by environmental triggers, including stress. This study aims to present a case of Graves' disease in children whose unusual trigger would be student abuse, a broad challenge with multiple implications. Read More

    Relationship between the abnormal diastolic vortex structure and impaired left ventricle filling in patients with hyperthyroidism.
    Medicine (Baltimore) 2017 Apr;96(17):e6711
    aDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan bDepartment of Ultrasound, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
    Intraventricular hydrodynamics plays an important role in evaluating cardiac function. Relationship between diastolic vortex and left ventricular (LV) filling is still rarely elucidated. The aim of this study was to evaluate the evolution of vortex during diastole in hyperthyroidism (HT) and explore the alteration of hydromechanics characteristics with sensitive indexes. Read More

    The High Calcium, High Phosphorus Rescue Diet Is Not Suitable to Prevent Secondary Hyperparathyroidism in Vitamin D Receptor Deficient Mice.
    Front Physiol 2017 10;8:212. Epub 2017 Apr 10.
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-WittenbergHalle, Germany.
    The vitamin D receptor (VDR) knockout (KO) mouse is a common model to unravel novel metabolic functions of vitamin D. It is recommended to feed these mice a high calcium (2%), high phosphorus (1.25%) diet, termed rescue diet (RD) to prevent hypocalcaemia and secondary hyperparathyroidism. Read More

    Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachment.
    Turk Pediatri Ars 2017 Mar 1;52(1):1-9. Epub 2017 Mar 1.
    Department of Pediatrics, Division of Neonatology and Pediatric Endocrinology, Erciyes University School of Medicine, Kayseri, Turkey.
    Fetal and neonatal hyperthyroidism may occur in mothers with Graves' disease. Fetal thyrotoxicosis manifestation is observed with the transition of TSH receptor stimulating antibodies to the fetus from the 17th-20th weeks of pregnancy and with the fetal TSH receptors becoming responsive after 20 weeks. The diagnosis is confirmed by fetal tachycardia, goiter and bone age advancement in pregnancy and maternal treatment is conducted in accordance. Read More

    FDA Approval Summary: Nivolumab for the Treatment of Relapsed or Progressive Classical Hodgkin Lymphoma.
    Oncologist 2017 May 24;22(5):585-591. Epub 2017 Apr 24.
    Office of Hematology and Oncology Products and Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
    On May 17, 2016, after an expedited priority review, the U.S. Food and Drug Administration granted accelerated approval to nivolumab for the treatment of patients with classical Hodgkin lymphoma (cHL) that has relapsed or progressed after autologous hematopoietic stem cell transplantation (HSCT) and post-transplantation brentuximab vedotin (BV). Read More

    Endocr Pract 2017 Apr;23(4):466-470
    Objective: Technetium thyroid uptake (TTU) is not inhibited by antithyroid drugs (ATD) and reflects the degree of thyroid stimulation. We intended to predict the relapse rate from hyperthyroidism based on TTU measurement.

    Methods: Out of 44 initially enrolled subjects, 38 patients aged 41. Read More

    [Iodine 131 joint radio frequency ablation treatment for child with hyperthyroidism goiter: one case report].
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 Jan;46(1):89-91
    Department of Ultrasonography, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
    A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8. Read More

    The association between thyroid disorders and incident gout: population-based case-control study.
    Clin Epidemiol 2017 6;9:205-215. Epub 2017 Apr 6.
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel.
    Context: Thyroid hormones influence kidney function and thereby might alter serum urate levels, a major risk factor for gouty arthritis.

    Objective: To assess the risk of developing incident gout in association with hypothyroidism or hyperthyroidism.

    Design: Retrospective population-based case-control analysis. Read More

    Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma).
    Med Sci Monit 2017 Apr 23;23:1947-1955. Epub 2017 Apr 23.
    Department of Clinical Laboratory, People's Hospital of Weifang, Weifang, Shandong, China (mainland).
    BACKGROUND Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin analogs have proved to be effective for inhibiting pituitary hormones secretion, working via interactions with somatostatin receptors (SSTRs). Moreover, antiproliferative activity of somatostatin analog is now demonstrated in several studies. Read More

    Involvement of gonadotropin-inhibitory hormone in pubertal disorders induced by thyroid status.
    Sci Rep 2017 Apr 21;7(1):1042. Epub 2017 Apr 21.
    Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Shinjuku-ku, Tokyo, 162-8480, Japan.
    Thyroid disorders cause abnormal puberty, indicating interactions between the hypothalamus-pituitary-thyroid (HPT) and hypothalamus-pituitary-gonadal (HPG) axes, which are important in pubertal development. The hypothalamic gonadotropin-inhibitory hormone (GnIH) was shown to be decreased in the early prepubertal stage, suggesting the role of GnIH on pubertal onset. Here, we investigated whether thyroid dysfunction affects pubertal onset in female mice via GnIH regulation. Read More

    Profiles Drug Subst Excip Relat Methodol 2017 6;42:287-338. Epub 2017 Apr 6.
    College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
    Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. Read More

    [Reversible first-degree atrioventricular block due to hyperthyroidism].
    Turk Kardiyol Dern Ars 2017 Apr;45(3):275-277
    Department of Cardiology, TOBB ETU Hospital, Ankara, Turkey.
    Hyperthyroidism often causes tachyarrhythmia. Reversible atrioventricular block caused by hyperthyroidism is rare occurrence. Presently described is a case of atrioventricular block due to hyperthyroidism and recovery after antithyroid treatment. Read More

    Impact of thyroid disease on testicular function.
    Endocrine 2017 Apr 20. Epub 2017 Apr 20.
    Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Via Santa Sofia 78, 95123, Catania, Italy.
    Introduction: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. Read More

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