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    Use of First-phase Insulin Secretion in Early Diagnosis of Thyroid Diabetes and Type 2 Diabetes Mellitus.
    Chin Med J (Engl) 2017 Apr;130(7):798-804
    Department of Endocrine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
    Background: A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus (T2DM) has been reported. Therefore, this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes (TDM) and T2DM.

    Methods: In total, 101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance (TNGT), hyperthyroidism with impaired glucose regulation (TIGR), and diabetes (TDM) groups. Read More

    Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study).
    J Endocrinol Invest 2017 Mar 25. Epub 2017 Mar 25.
    Unidad de Investigación en Epidemiología Clínica, Hospital General Regional No 1 Carlos McGregor Sánchez Navarro, Gabriel Mancera 222, Colonia Del Valle, Delegación, Benito Juárez, 03100, México, DF, Mexico.
    Introduction: Subclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly.

    Methods: We included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). Read More

    Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo.
    Comp Biochem Physiol C Toxicol Pharmacol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Pesticide Sciences, College of Plant Protection, Nanjing Agricultural University, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing, China. Electronic address:
    Methimazole (MMI) is an antithyroid agent widely used in the treatment of hyperthyroidism, and metabolized by cytochrome P450 enzymes and flavin-containing monooxygenases in mammals. However, drug overdose and the inadequate detoxification of the metabolite(s) are responsible for hepatocellular damage and organ dysfunction. Depending on the desired properties, Drosophila melanogaster has recently emerged as an ideal model organism for the study of human diseases. Read More

    Association of transient hyperthyroidism and severity of hyperemesis gravidarum.
    Horm Mol Biol Clin Investig 2017 Mar 23. Epub 2017 Mar 23.
    Background Transient non-immune hyperthyroidism in early pregnancy is hyperthyroidism diagnosed for the first time in early pregnancy, without evidence of thyroid autoimmunity or clinical findings of Grave's disease and resolved spontaneously as the pregnancy progressed. Hyperemesis gravidarum (HG) is the commonest cause with 66%-73% of women with severe HG were found to have elevated thyroid function. Materials and methods We conducted a cross sectional study to determine the prevalence of transient hyperthyroidism in patients with hyperemesis gravidarum and its relation to the severity of nausea and vomiting. Read More

    Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease.
    Viral Immunol 2017 Mar 23. Epub 2017 Mar 23.
    1 Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University , Yonago, Japan .
    Graves' disease is an autoimmune disease that results in and is the most common cause of hyperthyroidism, and the reactivation of persisting Epstein-Barr virus (EBV) in B lymphocytes induces the differentiation of host B cells into plasma cells. We previously reported that some EBV-infected B cells had thyrotropin receptor antibodies (TRAbs) as surface immunoglobulins (Igs), and EBV reactivation induced these TRAb+EBV+ cells to produce TRAbs. EBV reactivation induces Ig production from host B cells. Read More

    Graves' Ophthalmopathy in a Paediatric Population.
    Klin Monbl Augenheilkd 2017 Mar 22. Epub 2017 Mar 22.
    Oculoplastic surgery unit, Jules Gonin Eye Hospital, University of Lausanne, Switzerland.
    Background Graves' disease is an autoimmune disorder leading to hyperthyroidism. It is often associated with ophthalmic manifestations. Graves' disease is reported to be rare in the paediatric population. Read More

    Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update.
    Eur Heart J 2017 Feb 27. Epub 2017 Feb 27.
    Department of General Internal Medicine, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3010 Bern, Switzerland.
    Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptomatic. Individual participant data (IPD) analyses of prospective cohort studies from the international Thyroid Studies Collaboration show that SHypo is associated with increased coronary heart disease (CHD) mortality [hazard ratio (HR) 1,58 for TSH ≥ 10 mIU/L, 95% CI 1. Read More

    Association Between Non-Infectious Uveitis and Thyroid Dysfunction: A Case Control Study.
    Thyroid 2017 Mar 22. Epub 2017 Mar 22.
    1 Division of Ophthalmology, Tel Aviv Medical Center , Tel Aviv, Israel .
    Background: Several reports suggested a relation between uveitis and thyroid disease or dysfunction. However, no study has investigated the association between uveitis and thyroid dysfunction. The purpose of this study was to compare the prevalence of thyroid dysfunction in patients with and without non-infectious uveitis. Read More

    Rescue preoperative treatment with Lugol's solution in uncontrolled Graves' disease.
    Endocr Connect 2017 Mar 21. Epub 2017 Mar 21.
    H Falhammar, Institution for Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
    Background: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium-iodide to induce euthyroidism before surgery could be advocated but has rarely been reported. Read More

    Case report: fast reversal of severe osteoporosis after correction of excessive levothyroxine treatment and long-term follow-up.
    Osteoporos Int 2017 Mar 21. Epub 2017 Mar 21.
    Section for Diabetology and Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345, Gothenburg, Sweden.
    This case report describes a 38-year-old woman, who presented with bilateral femoral stress fractures and osteoporosis after years of excessive levothyroxine treatment. Her bone health was restored rapidly and long-lasting with the reduction of levothyroxine dosage. No bone-active treatment was warranted. Read More

    Methimazole associated eosinophilic pleural effusion: a case report.
    BMC Pharmacol Toxicol 2017 Mar 21;18(1):16. Epub 2017 Mar 21.
    Serviço de Medicina 2, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Avenida Prof. Egas Moniz, 1649-035, Lisbon, Portugal.
    Background: Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to thionamides have also been reported, two with propylthiouracil and three with carbimazole.

    Case Presentation: We report here a case of a 75-year-old man admitted because of unilateral pleural effusion. Read More

    Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.
    PLoS One 2017 20;12(3):e0174260. Epub 2017 Mar 20.
    Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
    Background: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. Read More

    Relationship Among Pulmonary Hypertension, Autoimmunity, Thyroid Hormones and Dyspnea in Patients With Hyperthyroidism.
    Am J Med Sci 2017 Apr 1;353(4):374-380. Epub 2017 Feb 1.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
    Objective: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism.

    Methods: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study. Read More

    Anesthetic Considerations in a Patient with Myotonic Dystrophy for Hip Labral Repair.
    Case Rep Anesthesiol 2017 20;2017:6408956. Epub 2017 Feb 20.
    Department of Anesthesiology, New York-Presbyterian, Columbia University Medical Center, New York, NY, USA.
    Myotonic Dystrophy (DM) affects multiple organ systems. Disorders such as hyperthyroidism, progressive musculoskeletal weakness, cardiac dysrhythmias, hypoventilation, and cognitive-behavioral disorders may be present in these patients. Thorough preoperative assessment and anesthetic planning are required to minimize the risk of anesthetic complications. Read More

    A Case-control Study of the Association between Ulcerative Colitis and Hyperthyroidism in an Asian Population.
    Clin Endocrinol (Oxf) 2017 Mar 18. Epub 2017 Mar 18.
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
    Objective: Ulcerative colitis (UC) is a chronic relapsing inflammatory disease with significant clinical diversity. However, the etiology, pathogenesis, and optimal treatment of UC remain unclear. The purpose of this case-control study was to investigate the association between previously diagnosed hyperthyroidism and UC using a large population-based dataset in Taiwan. Read More

    Complete hydatidiform mole with co-existing fetus: Predictors of live birth.
    Eur J Obstet Gynecol Reprod Biol 2017 Mar 7;212:1-8. Epub 2017 Mar 7.
    Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
    Multiple gestation consisting of complete hydatidiform mole with co-existing fetus (CHMCF) is unusual. From our institution, we reported two cases with unfavorable obstetric consequences. The recommendation for antenatal management is still not distinctly determined. Read More

    Management of thyroid eye disease in the United Kingdom: A multi-centre thyroid eye disease audit.
    Orbit 2017 Mar 15:1-11. Epub 2017 Mar 15.
    a Moorfields Eye Hospital , London , United Kingdom.
    This article aims to provide baseline data and highlight any major deficiencies in the current level of care provided for adult patients with thyroid eye disease (TED). We undertook a prospective, nonrandomized cross-sectional multicenter observational study. During a 3-month period June-August 2014, consecutive adult patients with TED who presented to nominated specialist eye clinics in the United Kingdom, completed a standardized questionnaire. Read More

    Thyrotoxic periodic paralysis: A case report.
    Int J Health Sci (Qassim) 2017 Jan-Mar;11(1):1-2
    Department of Medicine, King Saud Hospital, Post Box No. 1306, Unaizah 51911, AI Qassim, Saudi Arabia.
    Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by episodes of muscle weakness and hypokalemia. TPP is typically present in young Asian men, female, and non-Asian ethnic group can also be affected. TPP is a curable cause of hypokalemic periodic paralysis, can often be the first manifestation of thyrotoxicosis. Read More

    Cerebral Ischemia/Reperfusion Injury in the Hyperthyroid Rat.
    Iran J Med Sci 2017 Jan;42(1):48-56
    Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Hyperthyroidism as a risk factor for stroke is not conclusive. There are no definite data on the relationship between ischemic cerebrovascular injury and hyperthyroidism. This study was designed to define whether the outcomes of post-ischemic stroke injury are influenced by chronic hyperthyroidism. Read More

    [Acute psychosis secondary to dysthyroidism: about 2 cases].
    Pan Afr Med J 2016 6;25:216. Epub 2016 Dec 6.
    Hôpital Psychiatrique Ibn Alhassan, CHU Hassan II, Laboratoire Neurosciences Cliniques, Faculté de Médecine de Fès, Université Sidi Mohammed Ben Abdellah, Fès, Maroc.
    Thyroid function abnormalities are common and affect nearly 5% of the general population, with a female predominance. The occurrence of mental disorders, especially mood disorders, during thyroid diseases is known since a century, while psychotic disorders associated with dysthyroidisms are rarely described. We report 2 cases of patients with psychotic disorders showing two different situations: the first of which following hyperthyroidism with poor medication adherence and the second secondary to hypothyroidism after thyroidectomy. Read More

    [Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
    Ann Dermatol Venereol 2017 Mar 10. Epub 2017 Mar 10.
    Département de dermatologie, grand hôpital de Charleroi (GHDC), Grand'Rue 3, 6000 Charleroi, Belgique.
    Background: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). Read More

    Frequencies of PD-1- positive T CD3+CD4+, T CD3+CD8+ and B CD19+ lymphocytes in female patients with Graves' disease and healthy controls- preliminary study.
    Mol Cell Endocrinol 2017 Mar 8. Epub 2017 Mar 8.
    Department of Immunology, Medical University of Lublin, Lublin, Poland. Electronic address:
    PD-1 maintains tolerance and inhibits autoimmune responses. Graves' disease (GD) is one of the most frequent autoimmune diseases of unclear etiology. The aim of this study was to evaluate the percentage and absolute counts of PD-1 positive T and B cells in newly diagnosed, untreated patients with hyperthyroidism due to GD. Read More

    High dose of radioactive iodine per se has no effect on glucose metabolism in thyroidectomized rats.
    Endocrine 2017 Mar 10. Epub 2017 Mar 10.
    Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer. Pancreas expresses NIS and radioactive iodine uptake may damage pancreatic beta-cells and predispose patients to type 2 diabetes. The aim of this study was to determine whether radioactive iodine is associated with glucose metabolism in thyroidectomized rats. Read More

    Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies.
    PLoS One 2017 10;12(3):e0173722. Epub 2017 Mar 10.
    Department of Social and Preventive Epidemiology, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo, Japan.
    Background: Although several reports concerning the association of iodine excess and thyroid disease have appeared, no systematic review of the association between iodine excess intake and thyroid diseases, especially hyperthyroidism and hypothyroidism, has yet been reported.

    Method: We conducted a systematic search of Ovid MEDLINE, PubMed, Cochrane Central Register of Controlled Trials databases, Ichushi-Web and CiNii database for intervention trials and observational studies. Search terms were constructed from related words for excess AND iodine intake or excretion AND thyroid hormones or diseases AND study designs. Read More

    Dietary Management of Hyperthyroidism in a Dog.
    J Am Anim Hosp Assoc 2017 Mar/Apr;53(2):111-118
    From the Anesthesia Services, Massachusetts Veterinary Referral Hospital, Woburn, Massachusetts (A.L.); and the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York (J.W.).
    An 8 yr old female spayed golden retriever presented for a routine exam during which ventral cervical soft tissue masses were identified. History included weight loss, increased activity and appetite, gagging, and occasional diarrhea. Exam findings included a body condition score of 4/9 and palpable ventral cervical nodules. Read More

    Novel spiroimidazopyridine derivative SAK3 improves methimazole-induced cognitive deficits in mice.
    Neurochem Int 2017 Mar 7. Epub 2017 Mar 7.
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Electronic address:
    Methimazole (MMI) is a first-line therapy used to manage hyperthyroidism and Graves' disease. Despite its therapeutic benefit, chronic MMI administration can lead to hypothyroidism and perturb brain homeostasis in patients, resulting in neuropsychiatric disorders such as depression and cognitive dysfunction. We recently developed the spiroimidazopyridine derivative SAK3 as cognitive enhancer; however, mechanisms underlying its activity remained unclear. Read More

    A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management.
    J Clin Neurosci 2017 Mar 6. Epub 2017 Mar 6.
    Excellence Center for Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:
    Co-existence of thyrotropin/growth hormone-secreting pituitary adenoma with differentiated thyroid carcinoma is exceedingly rare, with less than 15 cases having been reported. Its clinical presentation and treatment strategy are challenging. We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Read More

    Diagnostic significance of serum concentrations of soluble Fas ligand (sFasL) in children with autoimmune thyroid disease.
    Autoimmunity 2017 Feb 21:1-7. Epub 2017 Feb 21.
    a Department of Pediatric Endocrinology and Rheumatology and.
    Introduction: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD).

    Design: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1. Read More

    Safety and Tolerability of PD-1/PD-L1 Inhibitors Compared with Chemotherapy in Patients with Advanced Cancer: A Meta-Analysis.
    Oncologist 2017 Mar 8. Epub 2017 Mar 8.
    UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
    Background: Compared with chemotherapy, significant improvement in survival outcomes with the programmed death receptor-1 (PD-1) inhibitors nivolumab and pembrolizumab and the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab has been shown in several types of advanced solid tumors. We conducted a systematic review and meta-analysis to compare safety and tolerability between PD-1/PD-L1 inhibitors and chemotherapy.

    Methods: PubMed and American Society of Clinical Oncology (ASCO) databases were searched 1966 to September 2016. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Subclinical Thyrotoxicosis: Prevalence, Causes and Choice of Therapy.
    Eur J Endocrinol 2017 Mar 8. Epub 2017 Mar 8.
    P Laurberg, Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
    Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication. Read More

    Learning Clinical Workflows to Identify Subgroups of Heart Failure Patients.
    AMIA Annu Symp Proc 2016 10;2016:1248-1257. Epub 2017 Feb 10.
    Vanderbilt University, Nashville, TN.
    Heart Failure (HF) is one of the most common indications for readmission to the hospital among elderly patients. This is due to the progressive nature of the disease, as well as its association with complex comorbidities (e.g. Read More

    Pituitary Adenoma Recurrence Suspected on Central Hyperthyroidism Despite Empty Sella and Confirmed by 68 Ga-DOTA-TOC PET/CT.
    Clin Nucl Med 2017 Mar 3. Epub 2017 Mar 3.
    From the *Hôpital Tenon, AP-HP, Médecine Nucléaire, Paris; †Université Pierre et Marie Curie, Paris; and ‡Hôpital Saint-Antoine, AP-HP, Endocrinologie, Paris, France.
    Thyrotropin-secreting pituitary adenomas are very rare tumors, known to present overexpression of somatostatin receptor subtype 2 and which may consequently demonstrate abnormal uptake on Ga-DOTA-TOC PET/CT. A 67-year-old woman with a history of operated pituitary macroadenoma presented with symptoms of hyperthyroidism including a large goiter. Her serum thyroid hormone levels were in favor of central hyperthyroidism. Read More

    Iodine supplementation for women during the preconception, pregnancy and postpartum period.
    Cochrane Database Syst Rev 2017 Mar 5;3:CD011761. Epub 2017 Mar 5.
    Research and Evaluation, Micronutrient Initiative, 180 Elgin Street, Suite 1000, Ottawa, ON, Canada, K2P 2K3.
    Background: Iodine is an essential nutrient required for the biosynthesis of thyroid hormones, which are responsible for regulating growth, development and metabolism. Iodine requirements increase substantially during pregnancy and breastfeeding. If requirements are not met during these periods, the production of thyroid hormones may decrease and be inadequate for maternal, fetal and infant needs. Read More

    Directional thyroid hormone distribution via the blood stream to target sites.
    Mol Cell Endocrinol 2017 Feb 28. Epub 2017 Feb 28.
    Department of Internal Medicine, Endokrinologikum Hamburg, Hamburg, Germany. Electronic address:
    Thyroid hormones are bound to three major serum transport proteins, thyroxin-binding globulin (TBG), transthyretin (TTR) and human serum albumin (HSA). TBG has the strongest affinity for thyroid hormones, TTR is also found in the cerebrospinal fluid and HSA is the most abundant protein in plasma. Combination defects of either a high affinity TTR or HSA variant do not compensate TBG deficiency, underscoring the dominant role of TBG among the thyroid hormone transport proteins. Read More

    Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation.
    Genome Integr 2017 23;8. Epub 2017 Jan 23.
    Central Laboratory for Radiological Protection, Laboratory of Dosimetry of the Radioactive Iodine in the Thyroid, Warsaw, Poland.
    Iodine-131 (I-131) is often used in thyroid diagnostics and therapy. External and internal exposure to radioiodine can lead to molecular and cellular damage in peripheral blood lymphocytes. The aim of this study was to explore the influence of low and high doses of I-131 on susceptibility to ionizing radiation. Read More

    ISFM Consensus Guidelines on the Diagnosis and Management of Hypertension in Cats.
    J Feline Med Surg 2017 Mar;19(3):288-303
    7 Associate Professor, Department of Clinical Sciences, Colorado State University, Campus Delivery 1678, Fort Collins, CO 80523, USA.
    Practical relevance: Feline hypertension is a common disease in older cats that is frequently diagnosed in association with other diseases such as chronic kidney disease and hyperthyroidism (so-called secondary hypertension), although some cases of apparent primary hypertension are also reported. The clinical consequences of hypertension can be severe, related to 'target organ damage' (eye, heart and vasculature, brain and kidneys), and early diagnosis followed by appropriate therapeutic management should help reduce the morbidity associated with this condition. Clinical challenges: Despite being a common disease, routine blood pressure (BP) monitoring is generally performed infrequently, probably leading to underdiagnosis of feline hypertension in clinical practice. Read More

    Hypothyroidism in McCune-Albright Syndrome and Role of Bone Scan in Management of Fibrous Dysplasia: An Unusual Case Scenario with Review of Literature.
    Indian J Nucl Med 2017 Jan-Mar;32(1):25-29
    Department of Nuclear Medicine, SGPGIMS, Lucknow, Uttar Pradesh, India.
    The McCune-Albright syndrome (MAS) is a triad of café-au-lait skin pigmentation, precocious puberty (PP), and polyostotic fibrous dysplasia of bone (FD). In general, FD seems to be the most common component of MAS but very rarely precocious puberty can be found in association with café-au-lait skin pigmentation in the absence of FD (about 1% of the cases). Therefore, a more clinically relevant definition of MAS is fibrous dysplasia of bone (FD) and at least one of the typical hyperfunctioning endocrinopathy and/or café-au-lait spots, with almost any combination possible. Read More

    Radioactive Iodine-131 as a Definitive Treatment in Rare Association of Down Syndrome With Hyperthyroidism: A Case Report and Review of Literature.
    Indian J Nucl Med 2017 Jan-Mar;32(1):19-24
    Department of Nuclear Medicine, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
    Down syndrome characterized by trisomy of chromosome 21 is frequently associated with thyroid dysfunctions due to underlying autoimmune disorders. Hypothyroidism is the commonest thyroid dysfunction and hyperthyroidism, usually Graves' disease, is far less common. On literature review, we came across approximately 112 cases reported so far with the first such case report in 1946. Read More

    Antithyroid arthritis syndrome.
    BMJ Case Rep 2017 Feb 27;2017. Epub 2017 Feb 27.
    Department of Endocrinology, Cooper University Hospital, Camden, New Jersey, USA.
    Antithyroid arthritis syndrome is a constellation of symptoms of myalgia, arthralgia, arthritis, fever and rash associated with the use of antithyroid medications. We report a case of a patient with severe hyperthyroidism likely secondary to Graves' disease who presented with the abovementioned symptoms after being treated with methimazole (antithyroid medication). Our aim is to increase awareness regarding this uncommon but disabilitating and life-threatening adverse effect of antithyroid medications among clinicians. Read More

    Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones.
    Sci Rep 2017 Feb 27;7:43380. Epub 2017 Feb 27.
    School of Chemistry, Sun Yat-sen University, Guangdong, Guangzhou 510275, China.
    In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, TGAb, and TMAb) were determined in 202 human serum samples of the general population of Guangdong, Guangxi and Hainan provinces in southern China. Σ8PFASs concentrations ranged from 0.85 to 24. Read More

    Nivolumab induced myxedema crisis.
    J Immunother Cancer 2017 21;5:13. Epub 2017 Feb 21.
    grid.416413.5Department of Hematology/Oncology, St. John Hospital and Medical Center, 19229 Mack Ave Suite 23 Grosse Pointe Woods, Detroit, 48236 Michigan USA.
    Background: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung.

    Case Presentation: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness. Read More

    Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea.
    J Am Acad Dermatol 2017 Feb 23. Epub 2017 Feb 23.
    Department of Dermatology, College of Medicine, Nowon Eulji Medical Center, Eulji University, Seoul, Korea. Electronic address:
    Background: Associations between vitiligo and thyroid diseases have been reported repeatedly.

    Objective: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database.

    Methods: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. Read More

    Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center.
    J Endocrinol Invest 2017 Feb 24. Epub 2017 Feb 24.
    Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi, People's Republic of China.
    Purpose: Antithyroid drug (ATD)-induced agranulocytosis is a rare but life-threatening adverse drug reaction that occurs in patients during the treatment of Graves' disease. We aimed to comprehensively examine data for patients with this rare complication and to improve the clinical safety of ATDs.

    Methods: We retrospectively reviewed the medical records of 64 hospitalized patients diagnosed with ATD-induced agranulocytosis between 2000 and 2015. Read More

    Comparison of endoscopic and conventional open thyroidectomy for Graves' disease: A meta-analysis.
    Int J Surg 2017 Feb 22;40:52-59. Epub 2017 Feb 22.
    Department of Surgery, Jinan University Institute for Minimally Invasive Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address:
    Background: Despite experience with the use of endoscopic surgical technology, there is controversy over the role of endoscopic thyroidectomy (ET) for Graves' disease (GD). This study aimed to conduct a meta-analysis to evaluate the cosmetic and safety outcomes of ET versus conventional open thyroidectomy (OT) for GD with respect to short-term consequences.

    Methods: We searched the following English language databases (Ovid MEDLINE, ISI Web of Science, and the Cochrane Library), and Chinese language databases (CNKI, CBMdisc, and SinoMed) between January 1996 and November 2015. Read More

    Risk of endocrine adverse events in cancer patients treated with PD-1 inhibitors: a systematic review and meta-analysis.
    Immunotherapy 2017 Mar;9(3):261-272
    Department of Radiation Oncology, Affiliated Hospital of Hebei University, 212 East Yuhua Road, Baoding 071000, Hebei, P R China.
    Aim: We conducted this meta-analysis to investigate the overall incidence and risk of endocrine complications in cancer patients treated with PD-1 inhibitors.

    Methods: Pubmed, Embase and oncology conference proceedings were searched for relevant studies.

    Results: In comparison with chemotherapy or everolimus or cetuximab control, PD-1 inhibitors significantly increased the risk of all grade hypothyroidism (relative risk: 6. Read More

    Progressive Ischemic Stroke due to Thyroid Storm-Associated Cerebral Venous Thrombosis.
    Am J Case Rep 2017 Feb 23;18:194-197. Epub 2017 Feb 23.
    Department of Nephrology, Endocrinology, and Diabetes, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Chiba, Japan.
    BACKGROUND Cerebral venous thrombosis (CVT) is a rare but fatal complication of hyperthyroidism that is induced by the hypercoagulable state of thyrotoxicosis. Although it is frequently difficult to diagnose CVT promptly, it is important to consider it in the differential diagnosis when a hyperthyroid patient presents with atypical neurologic symptoms. CASE REPORT A 49-year-old Japanese female with unremarkable medical history came in with thyroid storm and multiple progressive ischemic stroke identified at another hospital. Read More

    A rare case of ectopic ACTH syndrome originating from malignant renal paraganglioma.
    Arch Endocrinol Metab 2017 Feb 13. Epub 2017 Feb 13.
    Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Irfan Bastug Caddesi, Ankara, Turkey.
    Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of a non-pituitary ACTH-secreting tumor leading to Cushing's syndrome. Only a few cases have been reported previously as causing ectopic ACTH related to paraganglioma. Herein, we present a case of Cushing's syndrome, in who was proved to be attributable to an ACTH-secreting renal malignant paraganglioma. Read More

    Malignant melanoma with synchronous thyroid metastases: case report and literature review.
    Arch Endocrinol Metab 2017 Feb 16. Epub 2017 Feb 16.
    Department of Endocrinology, Diabetes and Metabolism, Faculty of Medicine University of Porto, Centro Hospitalar São João, Porto, Portugal.
    Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. Read More

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