50,134 results match your criteria Hyperthyroidism

Effects of Regular Whey Protein Consumption on Rat Thyroid Functions.

Turk J Med Sci 2021 May 14. Epub 2021 May 14.

Background/aim: We aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received Isole Hydrolyzed Whey Protein (IHWP) at different doses regularly and rats fed with only standard feed.

Material & Methods: Total 24 rats were divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Read More

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Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis.

Endocrine 2021 May 13. Epub 2021 May 13.

Department of Endocrinology, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, PR China.

Purpose: The current meta-analysis aimed to evaluate the association of thyroid dysfunction and autoimmunity with gestational diabetes mellitus (GDM).

Methods: A comprehensive search from PubMed, Embase, MEDLINE, and Cochrane databases until November 2020 was conducted. Fixed-effect model was used to combine the results when I was <50%. Read More

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Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study.

Eur Thyroid J 2021 Apr 8;10(2):150-160. Epub 2020 Jul 8.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background: Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain.

Methods: Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analyzed. Read More

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Utility of outpatient fractionated radioiodine therapy for Graves disease involving a large goiter measuring more than 100 mL in volume.

Endocr J 2021 May 11. Epub 2021 May 11.

Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan.

Contrary to large multinodular goiters, reports on I radioiodine therapy (RIT) for Graves disease (GD) involving a large goiter are scarce. We retrospectively reviewed a total of 71 consecutive patients (25 males, 46 females) with GD involving a large goiter (>100 mL) who had received RIT in our clinic. Patients with a history of thyroid surgery or with large thyroid nodules and those who had dropped out less than one year after the initial RIT session were excluded. Read More

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Symptomatic hypocalcemia after treatment for hyperthyroidism in a woman with chromosome 22q11.2 deletion syndrome complicated by Graves' disease: longitudinal changes in the number of subsets of CD4 and CD8 lymphocytes after thyroidectomy.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Endocrinology and Metabolism, Dokkyo Medical University, Tochigi 321-0293, Japan.

Chromosome 22q11.2 deletion syndrome is a multisystem genetic disorder that presents with hypocalcemia due to congenital hypoparathyroidism; cardiovascular, renal, and facial anomalies; and skeletal defects. This syndrome is also associated with an increased risk of autoimmune disease. Read More

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Relative Adrenocortical Insufficiency Following Radioactive Iodine Therapy for Graves' Disease: A Report of Two Cases.

Hanxin Zhao Yu Ruan

Int J Gen Med 2021 3;14:1641-1646. Epub 2021 May 3.

Department of Endocrinology and Metabolism, Zhejiang University Affiliated Sir Run Run Shaw Hospital, School of Medicine, Hangzhou, People's Republic of China.

Introduction: In recent years, radioactive iodine (RAI) therapy has become a main choice for Graves' disease. The rapid release of thyroid hormones following RAI may on occasion trigger severe events, such as thyroid storm or heart block. This study presents two cases of possible acute adrenocortical insufficiency precipitated by radioiodine therapy. Read More

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Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs.

Sci Rep 2021 May 11;11(1):9975. Epub 2021 May 11.

Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

This study was conducted to clarify the relationship between thyroid function and gastrointestinal motility. We established an experimental configuration in which the feedback of thyroid function was completely removed using conscious dogs. With hypothyroidism, time of phase I of interdigestive migrating contractions (IMC) was longer, time of phase II and phase III was significantly shortened, and both the continuous time of strong tetanic contraction at antrum and 10-h frequency of phase III counted from the first IMC after meal significantly decreased. Read More

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Refining age stratum of the CHEST score for predicting incident atrial fibrillation in a hospital-based Chinese population.

Eur J Intern Med 2021 May 8. Epub 2021 May 8.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China;. Electronic address:

Background: The CHEST score (C: coronary artery disease [CAD] / chronic obstructive pulmonary disease [COPD] (1 point each); H: Hypertension; E: Elderly (Age≥75, doubled); S: Systolic heart failure (doubled); T: Thyroid disease (hyperthyroidism)) has been validated to predict incident atrial fibrillation (AF). Its performance in the hospital-based Chinese population has never been evaluated.

Methods: Risk factors for incident AF were investigated in a hospital-based population. Read More

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Rapidly progressive cognitive decline associated with teprotumumab in thyroid eye disease.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Endocrinology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Teprotumumab (Tepezza), an insulin-like growth factor type 1 receptor antagonist, was approved for treatment of thyroid eye disease in 2020. Teprotumumab is administered intravenously every 3 weeks for a total of eight doses. Common side effects include nausea, diarrhoea, muscle spasms, hearing impairment, dysgeusia, headaches, dry skin, infusion reactions and hyperglycaemia. Read More

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Selected thyreology problems during the COVID-19 pandemic. Hypothyroidism and hyperthyroidism - did anything change?

Endokrynol Pol 2021 ;72(2):170-178

Chair and Department of Endocrinology, Metabolism, and Internal Medicine, University of Medical Sciences, Poznan, Poland.

On March 11, 2020, the World Health Organisation (WHO) observed the scale of epidemic risk and declared the state of the COVID-19 pandemic. Most countries, including Poland, implemented national and local emergency management plans to deal with the imminent threat of SARS-CoV-2 infection, one of the most serious in this century, according to many experts. In the era of pandemic, during which an epidemiological regime and social distancing are constantly recommended, and routine medical care and planned surgical procedures have been postponed or significantly reduced, patients and their physicians have to struggle on a daily basis with difficult access to diagnostic and therapeutic procedures. Read More

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January 2021

Risk factors for hypothyroidism and thyroid hormone replacement after hemithyroidectomy in papillary thyroid carcinoma.

Langenbecks Arch Surg 2021 May 10. Epub 2021 May 10.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.

Purpose: Thyroid lobectomy is now preferred over total thyroidectomy to preserve thyroid function and reduce complications in patients with low-risk papillary thyroid carcinoma (PTC). One inevitable consequence of thyroidectomy includes hypothyroidism. This study aimed to evaluate the risk factors for hypothyroidism and thyroid hormone replacement after hemithyroidectomy in patients with PTC. Read More

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Alström syndrome with a novel mutation of and Graves' hyperthyroidism: A case report and review of the literature.

World J Clin Cases 2021 May;9(13):3200-3211

Department of Pediatrics, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai 200025, China.

Background: Alström syndrome (AS, OMIM ID 203800) is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients. In the Chinese population, there are few reports on the clinical manifestations and pathogenesis of AS. This is the first report on the association between AS and Graves' hyperthyroidism. Read More

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Can we still consider thyroid hyperfunction a protective condition for the onset of thyroid cancer?

Gland Surg 2021 Apr;10(4):1359-1367

General Surgery Unit, Department of Medicine and Surgery, Parma University Hospital, Parma, Italy.

Background: Thyroid cancer is the ninth most commonly diagnosed cancer in the world, and the most common endocrine carcinoma. It was originally believed to be a rare event in patients with thyroid hyperfunction and it was reported that hyperthyroidism had a protective role against thyroid neoplasms. However, in recent years, several studies have hypothesized that differentiated thyroid carcinomas and hyperthyroidism may coexist. Read More

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Electrocardiograms Revealing Epsilon Waves Following Use of Hormone Supplements in Young Cardiac Arrest Patient.

Cureus 2021 Apr 5;13(4):e14305. Epub 2021 Apr 5.

Cardiology, Sanger Heart & Vascular Institute, Charlotte, USA.

Introduction: An underlying cardiomyopathy should be suspected in young patients presenting with ventricular arrhythmias and sudden cardiac arrest. Electrocardiograms revealing epsilon waves are associated with many serious conditions such as arrhythmogenic right ventricular cardiomyopathy, posterior myocardial infarction, right ventricular infarction, infiltration disease, sarcoidosis, Brugada Syndrome, Tetralogy of Fallot, and hypothermia. This case report features epsilon waves in a young cardiac arrest patient suspected of having an unrecognized cardiomyopathy that resulted in a fatal arrhythmia in the setting of exogenous bovine thyroid hormone and steroid use. Read More

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Testicular Germ Cell Tumors: Paraneoplastic Syndromes and the Role of Beta-Human Chorionic Gonadotropin.

Cureus 2021 Apr 4;13(4):e14286. Epub 2021 Apr 4.

Division of Hematology and Oncology, University of California Irvine, Irvine, USA.

Choriocarcinoma syndrome is a rare phenomenon that occurs in male patients with testicular choriocarcinoma. Male patients who have a testicular non-seminomatous germ cell tumor (TNSGCT) with at least partial choriocarcinoma histology, and metastases to the lungs and/or other extragonadal sites, as well as a markedly elevated beta-human chorionic gonadotropin (HCG), have been prone to pulmonary bleeding, hypoxia, and acute respiratory distress syndrome (ARDS). The respiratory complications occur immediately after chemotherapy is administered or, in some cases, spontaneously. Read More

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A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Department of Endocrine and Metabolic Diseases, Lab of Endocrine and Metabolic Research, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Summary: Resistance to thyroid hormone (RTH) is a rare hereditary syndrome with impaired sensitivity to thyroid hormones (TH) and reduced intracellular action of triiodothyronine (T3) caused by genetic variants of TH receptor beta (TRB) or alpha (TRA). RTH type beta (RTHβ) due to dominant negative variants in the TRB gene usually occurs with persistent elevation of circulating free TH, non-suppressed serum TSH levels responding to a thyrotropin-releasing hormone (TRH) test, an absence of typical symptoms of hyperthyroidism and goiter. Here, we present a rare variant in the TRB gene reported for the first time in an Italian patient with generalized RTHβ syndrome. Read More

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You cannot ablate the Lernaean Hydra: SCN5A mutation in a patient with multifocal ectopic Purkinje-related premature contractions syndrome treated with Flecainide and an implant of a subcutaneous defibrillator-a case report.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab158. Epub 2021 Apr 30.

University Hospital of Patras, Rio, Patras, 26504, Greece.

Background: SCN5A mutations may present with different clinical phenotypes such as Brugada syndrome, long QT3 syndrome, sick sinus syndrome, atrial fibrillation, dilated cardiomyopathy, and the least known multifocal ectopic Purkinje-related premature contractions syndrome.

Case Summary: We report a case of a 29-year-old woman with palpitations due to multifocal premature ventricular complexes (PVCs) and a family history of sudden death. The previous electrophysiological study had shown that PVCs arose from Purkinje fibres but catheter ablation was unsuccessful. Read More

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A Uniquely Challenging Case of Poorly Controlled Hyperthyroidism With a Coexisting Thyroglossal Cyst.

Cureus 2021 Apr 3;13(4):e14271. Epub 2021 Apr 3.

Internal Medicine, Salmaniya Medical Complex, Manama, BHR.

Hyperthyroidism is a common disease. Thyroglossal duct cysts are also a very common type of congenital anomalies. Their co-existence is, however, rare with only a few cases described in the literature of the same. Read More

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Application of Proteomics and Metabonomics to Reveal the Molecular Basis of Atractylodis Macrocephalae Rhizome for Ameliorating Hypothyroidism Instead of Hyperthyroidism.

Front Pharmacol 2021 20;12:664319. Epub 2021 Apr 20.

College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

As the treatments of diseases with Chinese herbs are holistic and characterized by multiple components, pathways, and targets, elucidating the efficacy of Chinese herbs in treating diseases, and their molecular basis, requires a comprehensive, network-based approach. In this study, we used a network pharmacology strategy, as well as proteomics and metabonomics, to reveal the molecular basis by which rhizome (AMR) ameliorates hypothyroidism. Eighteen main compounds from AMR and its fractions (volatile oil fraction, crude polysaccharides fraction, lactones fraction, oligosaccharide fraction, and atractyloside fraction) were identified by HPLC, and their targets were screened using the TCMSP database and Swiss Target Prediction. Read More

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Wireless and Flexible Skin Moisture and Temperature Sensor Sheets toward the Study of Thermoregulator Center.

Adv Healthc Mater 2021 May 6:e2100103. Epub 2021 May 6.

Department of Physics and Electronics, Osaka Prefecture University Sakai, Osaka, 599-8531, Japan.

A disorder in the thermoregulator center in a human body leads to some potential diseases such as fever and hyperthyroidism. To predict these diseases early, monitoring the health condition of the human body due to the influence of thermoregulation disorders is important. Although extensive works are performed on sweat-rate detection by constructing microfluidic channels, skin-moisture evaporation before sweating remains unknown. Read More

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Weathering the Storm: Thyroid Storm Precipitated by Radioiodine Contrast in Metastatic Thyroid Carcinoma.

Cureus 2021 Mar 31;13(3):e14219. Epub 2021 Mar 31.

Department of Pulmonary and Critical Care Medicine, Detroit Medical Center Sinai-Grace Hospital, Detroit, USA.

Thyroid storm is an extremely rare yet life-threatening medical emergency. It results from the decompensation of undiagnosed or undertreated hyperthyroidism in the presence of an acute stressor such as trauma to the thyroid, infections, acute iodine load, withdrawal from the antithyroid medication, or surgical procedures (including thyroid surgery). Clinical features of thyroid storm include hyperthermia, tachycardia, respiratory distress, gastrointestinal and hepatic symptoms, and central nervous system dysfunction. Read More

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The outcome of TSHoma from a tertiary care institute in India.

Surg Neurol Int 2021 14;12:161. Epub 2021 Apr 14.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is the rarest functioning pituitary adenoma.

Methods: A retrospective analysis of eight patients of TSHomas to highlight the presentations, diagnostic challenges, and treatment outcomes.

Results: Median age at diagnosis was 42 years, median latency to diagnosis was 2. Read More

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Changes in Thyroid Stimulating Hormone Receptor Antibody Levels Following Total Thyroidectomy or Radioiodine Therapy in Patients with Refractory Graves' Disease.

Thyroid 2021 May 5. Epub 2021 May 5.

Samsung Medical Center, 36626, Division of Endocrinology and Metabolism, Department of Medicine, Gangnam-gu, Seoul, Korea (the Republic of).

Background: The actions of thyrotropin-binding inhibitory immunoglobulins (TBIIs) against thyrotropin receptors in thyroid follicular cells have been studied as important etiological factors in Graves' disease (GD). The purpose of this study was to investigate changes in the TBII levels of patients undergoing total thyroidectomy (TTx) or radioactive iodine (RAI) therapy for GD refractory to antithyroid drugs (ATD).

Methods: We enrolled patients who underwent TTx or RAI for GD with previous ATD use between January 2011 and December 2017 at the Samsung Seoul Hospital in Seoul, Korea. Read More

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Graves' Disease Presenting as Autoimmune Hemolytic Anemia.

Am J Case Rep 2021 Apr 23;22:e930705. Epub 2021 Apr 23.

Hematology and Medical Oncology Unit, Department of Internal Medicine, Dr. Soetomo General Academic Hospital - Faculty of Medicine Airlangga University, Surabaya, Indonesia.

BACKGROUND Atypical manifestations of Graves' disease (GD) such as anemia have been noticed in the last decades. Anemia is present in up to 34% of patients with GD, yielding various anemia types such as GD anemia, pernicious anemia, iron deficiency anemia, and autoimmune hemolytic anemia (AIHA). So far, AIHA is the rarest manifestation of anemia in GD. Read More

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The adjunctive use of carbimazole during radioactive iodine treatment reduces the cure rate of Graves' disease.

S Afr Med J 2021 Feb 1;111(2):176-179. Epub 2021 Feb 1.

Department of Surgery, Faculty of Health Sciences, University of Pretoria, South Africa.

Background: Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, there is no consensus on the use of or timing of adjunctive ATD treatment with RAI. Read More

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February 2021

Patient centred choice of anti-thyroid drugs in the treatment of graves' disease.

J Pak Med Assoc 2021 Feb;71(2(B)):769-771

Department of Endocrinology, Amrita Institute of Medical Sciences, Kochi, India.

Antithyroid drugs (ATDs) are the mainstay of management of Graves' disease. While the choice of therapeutic modality namely anti-thyroid drugs, surgery and radio iodine ablation, has been studied in detail, less attention has been paid to the factors that influence choice of anti-thyroid medication. This article describes a patient centred approach to this challenge. Read More

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February 2021

Effect of preoperative potassium iodide administration on Graves' disease surgery: a propensity score analysis.

Am J Surg 2021 Apr 27. Epub 2021 Apr 27.

General and Digestive Surgery Department, Hospital Universitario de La Princesa, Madrid, Spain.

Background: Preoperative administration of a saturated solution of potassium iodide (SSKI) is recommended in the guidelines for the management of hyperthyroidism due to Graves' disease. Studies addressing its effect on complications after thyroidectomy are inconclusive.

Methods: Retrospective multicenter Propensity Score study of patients undergoing total thyroidectomy for Graves' disease, from January 2013 to September 2019 in two tertiary centers in Madrid, Spain. Read More

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Squamous Cell Carcinoma of the Lung in McCune-Albright Syndrome.

Cureus 2021 Mar 28;13(3):e14159. Epub 2021 Mar 28.

Internal Medicine, Detroit Medical Center (DMC) Harper Hospital, Detroit, USA.

McCune Albright Syndrome (MAS) is caused by a mutation in the GNAS gene that results in multiple endocrinopathies such as Cushing syndrome, acromegaly, hyperthyroidism, and precocious puberty. Despite the presence of pleiotropy coupled with a GNAS gene mutation, malignancy is a rare occurrence in MAS. There is minimal literature showcasing squamous cell carcinoma (SCC) of the lung in patients with MAS. Read More

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Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves' disease.

Clin Case Rep 2021 Apr 4;9(4):2281-2284. Epub 2021 Mar 4.

Department of Obstetrics and Gynecology FHU Prematurity Bichat Hospital Assistance publique-Hôpitaux de Paris Paris University Paris France.

We present a rare documented case with consecutive hypo- and hyperthyroidism during fetal life. First, hypothyroidism was due to transplacental passage of antithyroid drugs. After the mother's thyroidectomy, fetal hyperthyroidism was due to transplacental passage of persistent anti-thyrotropin receptor antibodies. Read More

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Changes in bone mineral density, 25-hydroxyvitamin D and inflammatory factors in patients with hyperthyroidism.

Exp Ther Med 2021 Jun 14;21(6):617. Epub 2021 Apr 14.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

The present study aimed to evaluate changes in bone mineral density, 25-hydroxyvitamin D [25-(OH)D] and inflammatory factors in patients with hyperthyroidism, in order to determine the correlations with the pathogenesis of hyperthyroidism. A total of 55 patients with hyperthyroidism (observation group) and 53 healthy patients (control group) enrolled at Weifang People's Hospital from March 2017 to February 2018 were randomly enrolled. The thyroid function, bone mineral density, 25-(OH)D and inflammatory factors were measured and compared between the two groups. Read More

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