48,992 results match your criteria Hyperthyroidism


Prevalence of, and factors associated with, positive urine cultures in hyperthyroid cats presenting for radioiodine therapy.

J Feline Med Surg 2020 Jun 1:1098612X20926090. Epub 2020 Jun 1.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.

Objectives: Urinary tract infections (UTIs) are reported to be relatively common in hyperthyroid cats, with prevalence rates ranging from 12% to 22%. Factors that are associated with UTIs include age, decreasing body weight and active urine sediments. The purpose of this study was to investigate the prevalence of positive urine cultures (PUCs) in hyperthyroid cats and associated risk factors for PUC. Read More

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http://dx.doi.org/10.1177/1098612X20926090DOI Listing

Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism.

Front Endocrinol (Lausanne) 2020 12;11:286. Epub 2020 May 12.

Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Hammersmith Hospital, Imperial College London, London, United Kingdom.

Graves' disease is the commonest cause of hyperthyroidism in populations with sufficient dietary iodine intake. Anti-thyroid drugs (ATD) are often used as the initial treatment for Graves' hyperthyroidism, however there is a paucity of data relating the dose of ATD therapy to the effect on thyroid hormone levels, increasing the risk of both over- and under-treatment. We aimed to determine the pharmacodynamic response to the ATD carbimazole. Read More

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http://dx.doi.org/10.3389/fendo.2020.00286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236601PMC

Thyroid isthmus agenesis and its clinical significance in a large-scale multidetector CT-based study.

Clin Imaging 2020 May 4;66:106-110. Epub 2020 May 4.

Department of Radiology, Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Objective: The purpose of this study was to estimate the incidence and clinical significance of thyroid isthmus agenesis based on multi-detector CT imaging in a large-scale study.

Methods: Data from 1601 patients who underwent neck multi-detector CT at our institution from January 2015 to March 2016 were included in this retrospective study. The morphology of each patient's thyroid gland was evaluated. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.038DOI Listing

Nanomagnetic lateral flow assay for high-precision quantification of diagnostically relevant concentrations of serum TSH.

Talanta 2020 Aug 4;216:120961. Epub 2020 Apr 4.

Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St, 119991, Moscow, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe shosse, 115409, Moscow, Russia. Electronic address:

Thyroid stimulating hormone (TSH) is the first-line marker for initial evaluation of the thyroid gland function. We present a lateral flow immunoassay based on superparamagnetic nanolabels for rapid (<25 min) quantitative determination of TSH at a point of care. The demonstrated limit of detection (LOD) of 0. Read More

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http://dx.doi.org/10.1016/j.talanta.2020.120961DOI Listing

Type 2 Autoimmune Polyglandular Syndrome Presenting with Hyperpigmentation and Amenorrhea.

Cureus 2020 Apr 21;12(4):e7772. Epub 2020 Apr 21.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

A 36-year-old female presented with lethargy, anorexia, nausea, hyperpigmentation, weight loss and amenorrhea for six months. On examination, she had hyperpigmentation of face, hands and oral mucosa. Investigations revealed adrenal insufficiency and subclinical hyperthyroidism with elevated anti-thyroid peroxidase antibodies. Read More

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http://dx.doi.org/10.7759/cureus.7772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243617PMC

Prevalence of Hypothyroidism among Dialysis Patients in Palestine: A Cross-Sectional Study.

Int J Nephrol 2020 13;2020:2683123. Epub 2020 May 13.

Department of Endocrinology, Istishari Arab Hospital, Ramallah, State of Palestine.

Introduction: The kidney affects the thyroid gland causing various derangements in its function whenever the kidney is impaired, even with a minor imperfection in its job, and this makes dialysis patients more prone to thyroid disorders with subsequent increase in mortality and morbidity. This study aims to assess the prevalence of thyroid disease (hypo- and hyperthyroidism) among dialysis patients and their associated factors.

Methods: This cross-sectional study was conducted in the dialysis unit of An-Najah National University Hospital. Read More

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http://dx.doi.org/10.1155/2020/2683123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243013PMC

Disruption of BMP signaling prevents hyperthyroidism-induced bone loss in male mice.

J Bone Miner Res 2020 May 26. Epub 2020 May 26.

Department of Medicine III, Universitätsklinikum Dresden, Technische Universität Dresden, Germany.

Thyroid hormones (TH) are key regulators of bone health, and TH excess in mice causes high bone turnover-mediated bone loss. However, the underlying molecular mechanisms of TH actions on bone remain poorly defined. Here, we tested the hypothesis whether TH mediate their effects via the pro-osteogenic bone morphogenetic protein (BMP) signaling pathway in vitro and in vivo. Read More

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http://dx.doi.org/10.1002/jbmr.4092DOI Listing

Thyroid uptake test with portable device (COTI) after I tracer administration: proof of concept.

Radiat Environ Biophys 2020 May 24. Epub 2020 May 24.

AG Medical Company, Saint Aubin, France.

COTI (collar therapy indicator) has been recently introduced for the detection of gamma rays with emphasis on thyroid investigations. The aim of this study was to test the feasibility of a prototype version of COTI including activity detectors with low sensitivity in performing thyroid uptake measurements for a large group of patients. Consequently, thyroid uptake tests were carried out for a total of 89 patients (22 males and 67 females; age: 44 ± 13 years) with thyroid cancer (n = 74), hyperthyroidism (n = 16) at 2 and 24 h after administration of 0. Read More

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http://dx.doi.org/10.1007/s00411-020-00849-8DOI Listing
May 2020
1.528 Impact Factor

Preoperative Potassium Iodide Treatment in Patients Undergoing Thyroidectomy for Graves' Disease-Perspective of a European High-Volume Center.

World J Surg 2020 May 23. Epub 2020 May 23.

Department of Endocrine Surgery, Schoen Clinic, Dehnhaide 120, 22081, Hamburg, Germany.

Background: Potassium iodide (KI) treatment affects the vascularity of the thyroid gland and therefore may improve intraoperative visualization of essential structures. However, clear evidence for its usage is lacking, and its implementation in patients suffering from Graves' disease is becoming rare. The objective of this retrospective study was to assess the impact of KI treatment on the intraoperative course and the outcome of patients undergoing thyroidectomy for Graves' diseases. Read More

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http://dx.doi.org/10.1007/s00268-020-05593-0DOI Listing

Medical treatment in thyroid eye disease in 2020.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Department of Surgery, University of Melbourne, Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia.

Thyroid eye disease (TED) affects 25% of patients with Graves' hyperthyroidism, where 1 in 20 patients has active, moderate-to-severe disease that will require medical treatment for reducing TED activity and severity. Intravenous corticosteroid has been the mainstay of treatment for active moderate-to-severe TED. With improved understanding of the pathophysiology of TED, immunotherapy targeting different molecular pathways including T cells, B cells, cytokines and cell surface receptors have been investigated in randomised clinical trials. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316051DOI Listing

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.

Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but important knowledge gaps remain regarding the effect of subclinical thyroid function test abnormalities on birthweight-both in general and during the late second and third trimester of pregnancy. The aim of this study was to examine associations of maternal thyroid function with birthweight. Read More

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http://dx.doi.org/10.1016/S2213-8587(20)30061-9DOI Listing

Management of Graves' hyperthyroidism and orbitopathy in time of COVID-19 pandemic.

J Endocrinol Invest 2020 May 21. Epub 2020 May 21.

Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, Viale Borri, 57, 21100, Varese, Italy.

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http://dx.doi.org/10.1007/s40618-020-01293-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241069PMC

Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor.

Anal Chem 2020 May 21. Epub 2020 May 21.

Hyperthyroidism-induced liver injury is quite common in clinic. Therefore, developing rapid and simple methods for the assessment of hyperthyroid liver injury is of great significance. Considering phosphorus metabolism is disordered because of hyperthyroidism, and the hyperthyroid liver injury is closely related to the abnormal level of glutathione (GSH). Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00925DOI Listing

Endocrinology in the time of COVID-19: Management of hyper- and hypo- thyroidism.

Eur J Endocrinol 2020 May 1. Epub 2020 May 1.

L Persani, IRCCS Istituto Auxologico Italiano, Universita degli Studi di Milano Dipartimento di Scienze Cliniche e di Comunita, Milano, 20149, Italy.

This manuscript provides guidance on the management of thyroid dysfunction during the COVID-19 pandemic. Auto-immune thyroid diseases are not linked to increased risks of COVID-19. Uncontrolled thyrotoxicosis may result in more severe complications from SARS-CoV-2 infection, including thyroid storm. Read More

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http://dx.doi.org/10.1530/EJE-20-0445DOI Listing

New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism.

Clin Endocrinol (Oxf) 2020 May 21. Epub 2020 May 21.

Biochemistry and Genetic Laboratory, Federative Institute of Biology, CHU Toulouse, Inserm UMR 1048, Team 6, Institute of Metabolic and Cardiovascular Diseases (I2MC), CHU Rangueil, Toulouse, France.

Context: Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.

Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for thyrotoxicosis with increased fT3 and fT4 concentrations and low TSH levels without anti-TSH receptor antibody. Thyrotoxicosis improved spontaneously during the 2nd trimester and persisted at the 3rd trimester. Read More

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http://dx.doi.org/10.1111/cen.14215DOI Listing

Platelet function in cats with hyperthyroidism.

J Feline Med Surg 2020 May 21:1098612X20920585. Epub 2020 May 21.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.

Objectives: Cats with hyperthyroidism have been reported to develop thromboembolism, with and without echocardiographic abnormalities consistent with hyperthyroidism. The objective of this study was to compare platelet function in cats with hyperthyroidism with euthyroid age-matched cats. We hypothesized that cats with hyperthyroidism have shortened collagen and adenosine diphosphate (C-ADP) closure times as measured with the platelet function analyzer (PFA-100) in comparison with healthy, age-matched controls. Read More

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http://dx.doi.org/10.1177/1098612X20920585DOI Listing

Effect of Different 131I Dose Strategies for Treatment of Hyperthyroidism on Graves' Ophthalmopathy.

Clin Nucl Med 2020 May 19. Epub 2020 May 19.

From the Nuclear Medicine Research Center.

Purpose: The study aims to define the effect of different dose strategies on ophthalmic complications in patients with Graves' disease (GD).

Methods: All the patients with GD and no or inactive ophthalmopathy (clinical activity score; CAS < 3) underwent Snellen chart examination, measurement of proptosis, thyroid volume, and radioactive iodine uptake, and randomized into 1 of 3 groups. In group 1, all the patients received fixed low dose (FLD) of 259 MBq of I, whereas in group 2, all the patients received fixed high dose (FHD) of 555 MBq, and in group 3, calculated dose (CD) was administered to deliver 5. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003086DOI Listing

Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review.

Cureus 2020 May 17;12(5):e8169. Epub 2020 May 17.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Thyrotoxic periodic paralysis (TPP) is a rare manifestation of hyperthyroidism. The pathophysiology of hyperthyroidism causing periodic paralysis involves the Na+/K+ ATPase and potassium channels. We present a case of a 30-year-old male who presented to the ED with acute onset of upper and lower limb weakness. Read More

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http://dx.doi.org/10.7759/cureus.8169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233982PMC

Subclinical thyroid dysfunction in 1st trimester of pregnancy: "disease" versus physiological (pulsatile) variation in TSH concentrations.

Clin Endocrinol (Oxf) 2020 May 19. Epub 2020 May 19.

Polish Mothers' Memorial Hospital - Research Institute, Department of Endocrinology and Metabolic Diseases, Lodz, Poland.

Background: There is no universal consensus regarding cut off points for TSH in pregnancy, so concentrations of 2.5 mIU/L or 4.0 mIU/L were suggested for 1 trimester (Endocrine Society (2012) and ATA (2017) guidelines, respectively). Read More

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http://dx.doi.org/10.1111/cen.14256DOI Listing

Population-Based Screening or Targeted Screening Based on Initial Clinical Risk Assessment for Atrial Fibrillation: A Report from the Huawei Heart Study.

J Clin Med 2020 May 15;9(5). Epub 2020 May 15.

Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, Merseyside L7 8TX, UK.

Background: A general-population approach has been advocated to improve the screening of patients with atrial fibrillation (AF). A more pragmatic alternative may be targeted screening of patients at high risk of developing AF. We assess the value of a simple clinical risk score, CHEST (C2, coronary artery disease/chronic obstructive pulmonary disease; COPD (1 point each); H, hypertension; E, elderly (age ≥75, doubled); S, systolic heart failure; HF (doubled); T, hyperthyroidism)); to facilitate population screening and detection of incident AF in the general population, in a prespecified ancillary analysis of the Huawei Heart Study. Read More

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http://dx.doi.org/10.3390/jcm9051493DOI Listing

Substernal Goiter: a case to remember.

Rev Assoc Med Bras (1992) 2020 May;66(2):109-111

. Department of Internal Medicine. Hospital Trofa Saúde Vila Real. Vila Real, Portugal.

Goiter is a localized or generalized thyroid hypertrophy. It can remain within the cervical region or grow down until it invades the mediastinum. The signs and symptoms depend on the size and location of the goiter. Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.109DOI Listing

Ophthalmic Surgeries and Systemic Medical Conditions Associated With the Development of Involutional Ptosis.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

Division of Orbital and Ophthalmic Plastic Surgery, Stein Eye Institute.

Purpose: To investigate the associations between systemic medical conditions and types of ocular surgery and the development of aponeurotic ptosis.

Methods: In this case-control observational cohort study, the relative prevalence of involutional ptosis in a large population of adult patients was assessed. Deidentified patient data from a 10-year time period was obtained from the electronic medical records of 5 large academic medical centers. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001707DOI Listing

Association between thyroid gland diseases and breast cancer: a case-control study.

Breast Cancer Res Treat 2020 May 18. Epub 2020 May 18.

Department of Gynecology and Obstetrics, Philipps University of Marburg, Marburg, Germany.

Background: At the present time, there is no consensus on the association between benign thyroid diseases and breast cancer (BC). Therefore, the aim of this study is to help shed some light on the association between hyperthyroidism, hypothyroidism, and thyroiditis and breast cancer risk.

Methods: Use of the Disease Analyzer database (IQVIA) enabled us to perform a retrospective case-control study of 7408 women aged between 18 and 80, who were treated for an initial breast cancer diagnosis in a general practice in the United Kingdom between 2006 and 2015 (index date). Read More

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http://dx.doi.org/10.1007/s10549-020-05675-6DOI Listing

Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice.

J Endocrinol 2020 Jul;246(1):41-55

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Subclinical hyperthyroidism, a condition characterized by decreased thyroid-stimulating hormone (TSH) and normal concentration of thyroid hormone, is associated with an elevated risk for cognitive impairment. TSH is the major endogenous ligand of the TSH receptor (TSHR) and its role is dependent on signal transduction of TSHR. It has not, however, been established whether TSHR signaling is involved in the regulation of cognition. Read More

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http://dx.doi.org/10.1530/JOE-20-0026DOI Listing

Surgical treatment of children Graves' disease with huge goiter-a case report and literature review.

Gland Surg 2020 Apr;9(2):467-473

Breast and Thyroid Surgical Department, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400000, China.

Graves' disease is the most common cause of hyperthyroidism in children. The surgery treatment for children Graves' disease with huge goiter is high risk and controversial. A 14-year-old girl suffered Graves' disease with huge goiter and failed to the antithyroid drug therapy for nearly 4 years was surgically treated with total thyroidectomy. Read More

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http://dx.doi.org/10.21037/gs.2020.02.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225450PMC

Somatostatin receptor profile in pituitary thyrotroph adenomas.

Clin Neurol Neurosurg 2020 Apr 22;195:105865. Epub 2020 Apr 22.

First Propaedeutic Department of Internal Medicine, Laikon Hospital, National and Kapodistrian University of Athens, Athens, Greece; Department of Pathology and Pituitary Tumor Reference Center, G. Gennimatas General Hospital of Athens, Greece. Electronic address:

Objectives: Thyrotroph adenomas are the most infrequent adenohypophysial tumors. Somatostatin (SST) inhibits hormone secretion and suppresses cell proliferation. SST receptors (sstr) belong to a family of 5 types of G-coupled membrane proteins, which show high binding affinity to SST. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105865DOI Listing

Association Between Thyroid Dysfunction and Incident Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.

J Endocrinol Metab 2019 Aug;9(4):82-89

University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, USA.

Background: Abnormal thyroid hormone levels (high or low) and autoimmunity from autoimmune thyroid disease (AITD) may increase dementia risk.

Methods: We examined the associations of thyroid dysfunction or possible AITD in 1990 - 1992 with dementia through 2017 in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study. Thyroid dysfunction (subclinical and overt hypo- or hyperthyroidism and euthyroidism) was categorized from serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) cut-points and AITD from anti-thyroid peroxidase (anti-TPO) antibody positivity. Read More

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http://dx.doi.org/10.14740/jem588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223793PMC

Amiodarone-induced thyrotoxicosis.

Ann Endocrinol (Paris) 2020 Apr 29. Epub 2020 Apr 29.

Service endocrinologie, AP-HP, hôpital Cochin, 75014 Paris, France; Université de Paris, 75014 Paris, France; Institut Cochin, Inserm Unité 1016, CNRS UMR 8104, 75014 Paris, France. Electronic address:

Amiodarone-induced thyrotoxicosis (AIT) are not uncommon endocrinopathies. Clinicians are sometimes faced with difficult diagnostic and therapeutic situations. The disease pathophysiology is partially understood, explaining the lack of predictive factors for occurrence. Read More

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http://dx.doi.org/10.1016/j.ando.2020.04.009DOI Listing

Improving treatment outcomes for Graves' disease patients with inactive forms of Graves' orbitopathy through an increased dose of radioiodine therapy.

Nuklearmedizin 2020 May 13. Epub 2020 May 13.

Bundeswehr Central Hospital Koblenz, Department of General, Visceral and Thoracic Surgery, Germany.

Introduction:  While surgical treatment is preferred for Graves' disease with active forms of GO, there are various concepts for treating inactive forms of GO. The goal of radioiodine therapy is to resolve immunogenic hyperthyroidism by damaging the thyroid cells.The effects of the radioiodine dose on an associated inactive GO remain unclear, however. Read More

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http://dx.doi.org/10.1055/a-1149-8552DOI Listing

Teprotumumab for Active Thyroid Eye Disease. Reply.

N Engl J Med 2020 05;382(20):1959-1960

Johannes Gutenberg University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1056/NEJMc2002754DOI Listing

Teprotumumab for Active Thyroid Eye Disease.

N Engl J Med 2020 05;382(20):1959

Cambridge University Hospitals, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMc2002754DOI Listing

Teprotumumab for Active Thyroid Eye Disease.

N Engl J Med 2020 05;382(20):1958-1959

University of California, San Francisco, San Francisco, CA

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http://dx.doi.org/10.1056/NEJMc2002754DOI Listing

Lessons from mouse models of Graves' disease.

Endocrine 2020 May 12. Epub 2020 May 12.

Laboratory of Molecular Ophthalmology, Medical Faculty, University Duisburg-Essen, Essen, Germany.

Graves' disease (GD) is an autoimmune condition with the appearance of anti-TSH receptor (TSHR) autoantibodies in the serum. The consequence is the development of hyperthyroidism in most of the patients. In addition, in the most severe cases, patients can develop orbitopathy (GO), achropachy and dermopathy. Read More

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http://dx.doi.org/10.1007/s12020-020-02311-7DOI Listing

Sistrunk Procedure on Malignant Thyroglossal Duct Cyst.

Case Rep Oncol Med 2020 16;2020:6985746. Epub 2020 Jan 16.

Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

A thyroglossal duct cyst is a lesion that occurs as a result from failure of the thyroglossal duct to obliterate during fetal development. Malignant progression is a rare event that might occur in less than 1% of all cases. Because of its rarity, there are conflicting opinions regarding the management of the case. Read More

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http://dx.doi.org/10.1155/2020/6985746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201451PMC
January 2020

Multiple autoimmune side effects of immune checkpoint inhibitors in a patient with metastatic melanoma receiving pembrolizumab.

J Oncol Pharm Pract 2020 May 9:1078155220921543. Epub 2020 May 9.

Department of Hematology/Oncology, University of Connecticut, CT, USA.

Introduction: Immune agents including anti-programmed death receptor-1 and anti-cytotoxic T-lymphocyte antigen-4 have been associated with numerous immune-related complications. Pembrolizumab, a programmed death-1 inhibitor, has been associated with a number of immune-related adverse events such as pneumonitis, colitis, hepatitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and type 1 diabetes.

Case Report: We present a rare case of an elderly male on pembrolizumab who suffered from four autoimmune toxicities including type 1 diabetes, pneumonitis, hypothyroidism, and polymyalgia rheumatica likely catalyzed by age-related immune activation. Read More

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http://dx.doi.org/10.1177/1078155220921543DOI Listing

Complex Disease Management: Managing a Cat with Comorbidities.

Authors:
Margie Scherk

Vet Clin North Am Small Anim Pract 2020 May 7. Epub 2020 May 7.

catsINK, Vancouver BC, Canada. Electronic address:

Many older cats often suffer concurrently from multiple conditions. By focusing on the common concerns, rather than conflicting requirements, a management program can be devised. Optimize hydration, nutrition, and ensure comfort though providing analgesia and a low-stress environment in which the patient's feline-specific nature is respected both in the clinic and at home. Read More

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http://dx.doi.org/10.1016/j.cvsm.2020.03.006DOI Listing

Impaired Cardiovascular Function in Male Rats with Hypo- and Hyperthyroidism: Involvement of Imbalanced Nitric Oxide Synthase Levels.

Endocr Metab Immune Disord Drug Targets 2020 May 8. Epub 2020 May 8.

Endocrine Physiology Research Center, Research institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Background And Objective: All three isoforms of nitric oxide (NO) synthase (NOS) are targets for thyroid hormones in cardiovascular system. The aim of this study was to assess effects of hypoand hyperthyroidism on inducible (iNOS), endothelial (eNOS), and neural (nNOS) NOS levels in aorta and heart tissues of male rats.

Methods: Rats were divided into control, hypothyroid, and hyperthyroid groups; hypo- and hyperthyroidism were induced by adding propylthiouracil (500 mg/L) and L-thyroxine (12 mg/L) to drinking water for a period of 21 days, respectively. Read More

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http://dx.doi.org/10.2174/1871530320666200508115543DOI Listing

Association between Thionamides and Acute Pancreatitis: A Case-control Study.

Thyroid 2020 May 7. Epub 2020 May 7.

China Medical University Hospital, 38020, Division of Endocrinology and Metabolism, Department of Medicine, Taichung, Taiwan.

Background: Thionamides have been extensively used to treat patients with hyperthyroidism worldwide. Recent pharmacovigilance studies have revealed a safety signal between carbimazole or methimazole and pancreatitis. The associated risk remains unclear. Read More

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http://dx.doi.org/10.1089/thy.2019.0589DOI Listing
May 2020
4.493 Impact Factor

Incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia.

Wien Klin Wochenschr 2020 May 6. Epub 2020 May 6.

Department of Nuclear medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1525, Ljubljana, Slovenia.

Background: The incidence of thyroid disorders importantly depends on iodine supply and may change over time. There are only a few data available regarding the change in the incidence of thyroid disorders following the increase in iodine supply. Therefore, the aim of this study was to establish the incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia. Read More

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http://dx.doi.org/10.1007/s00508-020-01662-5DOI Listing

Hematological and serum biochemical profile in cattle experimentally infected with foot-and-mouth disease virus.

Vet World 2020 Mar 9;13(3):426-432. Epub 2020 Mar 9.

Indian Council of Agricultural Research-Indian Veterinary Research Institute, Bengaluru, Karnataka, India.

Background And Aim: Foot-and-mouth disease (FMD) is an acute viral infection affecting cloven-hoofed animals causing vesicular erosions in the oral cavity and interdigital space. The present study was undertaken to ascertain the time-dependent changes in clinical, hematological, and biochemical profiles in different breeds of cattle following experimental infection.

Materials And Methods: The animals were inoculated with 1. Read More

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http://dx.doi.org/10.14202/vetworld.2020.426-432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183469PMC

Prevalence of thyroid dysfunction in healthy adults according to the estimated iodine intake in 24-hour urine samples: The SALMEX cohort.

Eur J Nutr 2020 May 3. Epub 2020 May 3.

Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Purpose: The aim of this study was to evaluate the prevalence of thyroid dysfunction in a cohort of healthy individuals in Mexico City, as well as to investigate the potential associations of these results with their estimated iodine intake (EII) as reflected by their 24-hour urinary iodine excretion (24-h UIE).

Methods: From the SALMEX cohort, 683 adults provided an appropriate 24-h urine sample. Thyroid function tests and thyroid antibody concentrations were determined in the participants' sera. Read More

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http://dx.doi.org/10.1007/s00394-020-02254-9DOI Listing
May 2020
3.467 Impact Factor

Associating radioiodine therapy in hyperthyroidism with cancer mortality: robust or random results of a statistical analysis?

Hell J Nucl Med 2020 Jan-Apr;23(1):94-95

Academic Department of Nuclear Medicine, University Hospital AHEPA, School of Medicine, 54621 Thessaloniki, Greece.

Dear Editor, Recently, Kitahara et al. (2019) published an article in JAMA Internal Medicine entitled "Association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism". This publication was based on organ dosimetry calculations from 18,805 patients with hyperthyroidism treated with radioiodine treatment (RAI) followed for nearly 7 decades. Read More

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http://dx.doi.org/10.1967/s002449912018DOI Listing

Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models.

FASEB J 2020 May 1. Epub 2020 May 1.

Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea.

Thyroid hormones are essential for the regulation of energy homeostasis and metabolic processes. However, the relationship between thyroid function and host gut microbial communities is not properly understood. To determine whether and how gut microbiota is associated with thyroid function, metagenomics analysis of the bacterial population in fecal samples of rat models of hyperthyroidism (induced by levothyroxine) and hypothyroidism (induced by propylthiouracil or thyroidectomy) was conducted through 16S rRNA gene sequencing. Read More

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http://dx.doi.org/10.1096/fj.201903091RRDOI Listing

[Recurrent ventricular tachycardia as a cause of circulatory decompensation in the case of various comorbid diseases].

Pol Merkur Lekarski 2020 Apr;48(284):97-99

Department of Cardiology, District Hospital in Chrzanów, Poland.

Ventricular arrhythmias, including tachycardia and ventricular fibrillation are often a dangerous consequence other co-existing conditions in the phase of their destabilization. Causal and symptomatic treatment diseases such as: ischemic heart disease, cardiac insufficiency, hyperthyroidism, or cancer, can be effectively stabilized without necessity for the implantation of cardioverter-defibrillator (ICD).

Case Report: The 62-year-old patient was admitted to the cardiology department after a second episode of unconsciousness last week due to recurrent VT. Read More

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Gender-specific association between body mass index and all-cause mortality in patients with atrial fibrillation.

Clin Cardiol 2020 Apr 30. Epub 2020 Apr 30.

Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Background: Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.

Hypothesis: Gender-specific association between BMI and mortality exists in atrial fibrillation (AF).

Methods: In this multicenter observational study with a mean follow-up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender. Read More

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http://dx.doi.org/10.1002/clc.23371DOI Listing

Maternal Thyroid Dysfunction and Gestational Anemia Risk: Meta-Analysis and New Data.

Front Endocrinol (Lausanne) 2020 15;11:201. Epub 2020 Apr 15.

Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, China.

Previous studies indicate the effects of thyroid dysfunction on adverse obstetric outcomes and fetal neurodevelopment, of which the results on gestational anemia are controversial. Here, we evaluated the influence of thyroid dysfunction on gestational anemia via published epidemiological articles and a new prospective study conducted by our team, respectively. We searched studies on the PubMed, Embase, MEDLINE, and Cochrane databases as of November 2019, and conducted a prospective study in which participants underwent thyroid function and blood routine testing throughout pregnancy. Read More

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http://dx.doi.org/10.3389/fendo.2020.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174567PMC

Retrospective Study of Tc-99m Thyroid Scan in Patients with Graves' Disease: Is There Significant Difference in Lobar Activity?

Indian J Nucl Med 2020 Apr-Jun;35(2):122-129. Epub 2020 Mar 12.

Internal Medicine Department, East Jeddah Hospital, Jeddah, Saudi Arabia.

Purpose: Graves' disease (GD) is the most common cause of hyperthyroidism. It was reported that the right thyroid lobe is generally larger, and it is more likely to be affected by thyroid disorders. The aim of the current study is to verify preferential affection of one of the thyroid lobes and incidence of higher activity of either thyroid lobe in patients with GD through analysis of quantitative data of Tc-99m thyroid scan and possible relation of different thyroid lobar activity to gender, age, and total thyroid uptake (TTU) level. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_186_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182335PMC

ThyroSeq v2 Testing: Impact on Cytologic Diagnosis, Management, and Cost of Care in Patients with Thyroid Nodule.

Thyroid 2020 Apr 29. Epub 2020 Apr 29.

Boston Medical Center, 1836, Department of Pathology, 670 Albany street, Boston, Massachusetts, United States, 02118;

Background: Novel molecular tests, such as ThyroSeq, may improve the management of thyroid nodules with indeterminate cytologic diagnoses; however, the impact of these tests on cost and outcome of management is unknown. Here we evaluated the impact of ThyroSeq testing on the cytopathologic diagnosis, management, and cost of care of patients with thyroid nodules.

Methods: In a retrospective study, using actual patient cohorts, the outcome and cost of management of patients with thyroid nodules seen before the introduction of ThyroSeq v2 at our institution (Standard of Care (StC) cohort) were compared with those seen after the introduction of this test (Molecular Test (MT) cohort). Read More

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http://dx.doi.org/10.1089/thy.2019.0191DOI Listing

Medical Event: Accidental Oral Administration of 177Lu-PSMA to a Patient With Hyperthyroidism.

Clin Nucl Med 2020 Jun;45(6):439-441

From the Nuclear Medicine Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

A 74-year-old woman with hyperthyroidism was referred for radioiodine therapy. The patient was accidentally given 60 mCi of Lu-PSMA orally instead of I. Upon discovery of this medical event, we immediately started radiation protective actions including hydration, antiemetics, and laxatives. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003026DOI Listing

Thyrotoxic periodic paralysis presenting in an African-American teenage male: case report.

Int J Pediatr Endocrinol 2020 24;2020. Epub 2020 Apr 24.

2Division of Endocrinology, Department of Pediatrics, Stony Brook Children's Hospital, 101 Nicolls Road, HSC-T11, Room 040, Stony Brook, NY 11794 USA.

Background: Thyrotoxic periodic paralysis is a rare complication of hyperthyroidism and is associated with hypokalemia and muscle paralysis. This condition is most commonly seen in Asian men.

Case Presentation: We report on a 14-year-old African American male with Graves' disease and intermittent asthma who presented with bilateral leg weakness. Read More

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http://dx.doi.org/10.1186/s13633-020-00077-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181516PMC