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    The risk of immune-related endocrine disorders associated with anti-PD-1 inhibitors therapy for solid tumors: A systematic review and meta-analysis.
    Int Immunopharmacol 2018 Apr 18;59:328-338. Epub 2018 Apr 18.
    Department of Pathology, Research Institute of McGill University Health Center, Montreal, Quebec, Canada. Electronic address:
    Background: We performed a systematic review and meta-analysis to evaluate the risk of immune-related endocrine disorders associated with PD-1 inhibitors therapy for solid tumors.

    Methods: An Embase and PubMed search through December 6, 2017, using the following keywords was performed: immune-related endocrine disorders, and PD-1 inhibitors, etc. The data were analyzed using R 3. Read More

    De novo SOX10 Nonsense Mutation in a Patient with Kallmann Syndrome, Deafness, Iris Hypopigmentation, and Hyperthyroidism.
    Ann Clin Lab Sci 2018 Mar;48(2):248-252
    The Endocrinology Department of the Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    Kallmann syndrome (KS) is a clinically and genetically heterogeneous disorder characterized by hypogonadotropic hypogonadism and olfactory dysfunction. Recently, mutations in SOX10, a well-known causative gene of Waardenburg syndrome (WS), have been identified in a few KS patients with additional developmental defects including hearing loss. However, the understanding of SOX10 mutation associates with KS and other clinical consequences remains fragmentary. Read More

    Scoliosis in Fibrous Dysplasia/McCune-Albright Syndrome: Factors Associated with Curve Progression and Effects of Bisphosphonates.
    J Bone Miner Res 2018 Apr 18. Epub 2018 Apr 18.
    Section on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD.
    Background: Scoliosis is a complication of fibrous dysplasia/McCune-Albright syndrome (FD/MAS), however risk factors and long-term outcomes are unknown. Bisphosphonates are commonly used; however, it is unknown whether their use decrease the risk of progressive scoliosis.

    Methods: Clinical data from the NIH cohort study was reviewed. Read More

    Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?
    Contrast Media Mol Imaging 2018 13;2018:4898365. Epub 2018 Feb 13.
    Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki 889-1692, Japan.
    Objective: We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH.

    Methods: Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group. A total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. Read More

    Hypothyroidism and hyperthyroidism change ectoenzyme activity in rat platelets.
    J Cell Biochem 2018 Apr 16. Epub 2018 Apr 16.
    Programade Pós-Graduação em Ciências Biológicas Bioquímica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Rio Grande do Sul, Brasil.
    The purinergic system has an important role in the regulation of vascular functions. The interference of thyroid hormones in this system and in cardiovascular events has been studied in recent years. However, the mechanisms involved in vascular, purinergic, and oxidative changes in thyroid disorders are not completely understood. Read More

    ShearWave™ elastography for evaluation of the elasticity of Hashimoto's thyroiditis.
    Clin Hemorheol Microcirc 2018 Apr 13. Epub 2018 Apr 13.
    Department of Ultrasound Diagnosis, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing, P.R. China.
    The aim of this study was to assess the elasticity of Hashimoto's thyroiditis in the different processes via supersonic ShearWave™ Elastography (SWE™). Quantitative information is delivered as Young's modulus value expressed in kilo-Pascal (kPa). 30 healthy female and 30 healthy male individuals aging at 40±20 y had undergone conventional ultrasonography and SWE to determine the influence of gender on elasticity of thyroid. Read More

    The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats.
    Toxicology 2018 Apr 13;402-403:1-8. Epub 2018 Apr 13.
    Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian University, Medyczna 9, PL 30-688, Kraków, Poland. Electronic address:
    Benzophenones used as UV filters, in addition to the effects on the skin, can be absorbed into the blood and affect the function of certain organs. So far, their effects on the sex hormone receptors and gonadal function have been studied, but not much is known about their potential action on other systems. The aim of the present study was to determine the effect of benzophenone-2 (BP-2) on immune system activity, hypothalamic-pituitary-thyroid (HPT) axis activity and hematological parameters. Read More

    Subclinical thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men.
    Clin Endocrinol (Oxf) 2018 Apr 14. Epub 2018 Apr 14.
    School of Medicine, University of Western Australia, Perth, Western, Australia.
    Objective: Overt thyroid dysfunction is a risk factor for osteoporosis and fractures. Subclinical hyperthyroidism has also been associated with fracture. It remains unclear whether variation in thyroid hormones within the euthyroid range modulates bone health, particularly among older men. Read More

    Linear Analysis of Autonomic Activity and Its Correlation with Creatine Kinase-MB in Overt Thyroid Dysfunctions.
    Indian J Clin Biochem 2018 Apr 5;33(2):222-228. Epub 2017 May 5.
    1Department of Physiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan 342005 India.
    Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. Read More

    PREDICTIVE SCORE FOR THE DEVELOPMENT OR PROGRESSION OF GRAVES' ORBITOPATHY IN PATIENTS WITH NEWLY DIAGNOSED GRAVES' HYPERTHYROIDISM.
    Eur J Endocrinol 2018 Apr 12. Epub 2018 Apr 12.
    T Brix, Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, 5000, Denmark.
    To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers from EUGOGO in 8 European countries. 348 patients were included with untreated GH but without obvious GO. Read More

    Flushing Disorders Associated with Gastrointestinal Symptoms: Part 2, Systemic Miscellaneous Conditions.
    Clin Med Res 2018 Apr 12. Epub 2018 Apr 12.
    University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605
    Flushing disorders with involvement of the gastrointestinal tract represent a heterogeneous group of conditions. In part 1 discussed were neuroendocrine tumors (NET), mast cell activation disorders (MCAD), and hyperbasophilia. In this section are covered the remaining flushing disorders which primarily or secondarily involves the gastrointestinal tract. Read More

    Flushing Disorders Associated with Gastrointestinal Symptoms: Part 1, Neuroendocrine Tumors, Mast Cell Disorders and Hyperbasophila.
    Clin Med Res 2018 Apr 12. Epub 2018 Apr 12.
    University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605
    Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands. Read More

    The Radioprotective Effects of Curcumin and Trehalose Against Genetic Damage Caused By I-131.
    Indian J Nucl Med 2018 Apr-Jun;33(2):99-104
    Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
    Background: Thyroid cancer has been growing rapidly during the last decades. Radioiodine-131 (I-131) as an appropriate therapy modality is currently using in the treatment of cancer and hyperthyroidism diseases. This radiotracer is considered as a cause of oxidative DNA damage in nontarget cells and tissues. Read More

    Dynamic changes of central thyroid functions in the management of Cushing's syndrome.
    Arch Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul, Turkey.
    Objective: The aim of this study was to determine the frequency of central thyroid dysfunctions in Cushing's syndrome (CS). We also aimed to evaluate the frequency of hyperthyroidism due to the syndrome of the inappropriate secretion of TSH (SITSH), which was recently defined in patients with insufficient hydrocortisone replacement after surgery.

    Materials And Methods: We evaluated thyroid functions (TSH and free thyroxine [fT4]) at the time of diagnosis, during the hypothalamo-pituitary-adrenal axis recovery, and after surgery in 35 patients with CS. Read More

    The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.
    Am J Surg Pathol 2018 May;42(5):587-594
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

    Thyroid Disorders in Subjects with Down Syndrome: An Update.
    Acta Biomed 2018 Mar 27;89(1):132-139. Epub 2018 Mar 27.
    Department of Paediatrics Ain Shams University, Cairo, Egypt.
    Down syndrome (DS) is the commonest chromosomal disorder among live born infants. DS is associated with increased risk of endocrine abnormalities particularly thyroid gland disorders. The spectrum of thyroid dysfunction in patients with DS include congenital hypothyroidism, subclinical hypothyroidism, acquired hypothyroidism (autoimmune - non autoimmune), and hyperthyroidism. Read More

    A comparison of the effects of seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism.
    Avicenna J Phytomed 2018 Mar-Apr;8(2):161-169
    Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
    Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of () seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism.

    Materials And Methods: Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline. Read More

    Type 2 Diabetes Decompensation as the Clinical Presentation of Thyroid Storm - Cause or Consequence?
    Eur Endocrinol 2017 Aug 22;13(2):99-101. Epub 2017 Aug 22.
    Endocrinology Department, Hospital de Braga, Braga, Portugal.
    This case study aims to discuss the unusual forms of hyperthyroidism presentation, the nonspecific symptoms and precipitating events. A 70-year-old male was taken to the emergency department for hyperglycaemia, nausea, vomiting and altered mental status with a week of evolution. He had a past medical history of type 2 diabetes, hypertension and dyslipidemia. Read More

    Takotsubo Cardiomyopathy Associated with Levothyroxine Over-replacement.
    Eur Endocrinol 2017 Apr 3;13(1):30-32. Epub 2017 Apr 3.
    Department of Endocrinology, Diabetes and Nutrition, Hospital Centre of Baixo Vouga, Aveiro, Portugal.
    Takotsubo cardiomyopathy (TC) is characterised by acute, transient left ventricular apical ballooning precipitated by emotional or physiologically stressful stimuli and has been previously associated with Grave's disease based on a few clinical reports. More recently, the association with exogenous thyrotoxicosis and radioiodine-induced thyroiditis has also been described. Iatrogenic hyperthyroidism on patients on levothyroxine replacement therapy for hypothyroidism has not been reported as a cause of TC. Read More

    Thyroid Dysfunction and Anemia: A Prospective Cohort Study and a Systematic Review.
    Thyroid 2018 Apr 10. Epub 2018 Apr 10.
    Inselspital Universitatsspital Bern, 27252, Department of General Internal Medicine, Bern, Switzerland.
    Background: Even though the association between thyroid dysfunction and anemia is commonly described, we do not know if it is clinically relevant. We set out to quantify the association of thyroid dysfunction on hemoglobin (Hb) concentration and risk of anemia, and conducted a systematic review (MEDLINE & EMBASE, from inception until May 15th, 2017) to interpret our findings in context.

    Methods: We included participants from the EPIC-Norfolk cohort with available baseline thyroid-stimulating hormone (TSH), free thyroxine (fT4), and Hb. Read More

    High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism.
    Life Sci 2018 Apr 4. Epub 2018 Apr 4.
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:
    Aims: High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high fat (HFD) diets in hypo or hyperthyroidism-induced condition.

    Material And Methods: C57BL/6 male mice fed LFD or HFD diets for 12 weeks, followed by saline, PTU (antithyroid drug) or T3 treatment up to 30 days. Read More

    Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease.
    PLoS One 2018 5;13(4):e0195464. Epub 2018 Apr 5.
    Department of Medicine II, Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
    Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR] is a multi-functional protein that activates the tissue renin-angiotensin system and is an essential constituent of vacuolar H+-ATPase, necessary for the autophagy-lysosome pathway. (P)RR is cleaved to soluble (s)(P)RR, which reflects the status of (P)RR expression. Read More

    Use of low-dose neostigmine intravenously in the treatment of thyroid storm-induced severe tachycardia in patient during huge pelvic mass resection: A case report and review of literature.
    Medicine (Baltimore) 2018 Apr;97(14):e0300
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Rationale: Thyroid storm is a rare and life-threatening metabolic crisis because of an emergent release of excess thyroid hormone. Sinus tachycardia induced by excess thyroid hormone may result in congestive heart failure due to decreased diastolic filling time.

    Patient Concerns: A controlled hyperthyroidism patient with severe sinus tachycardia. Read More

    Prediction of Neonatal Hyperthyroidism.
    J Pediatr 2018 Mar 28. Epub 2018 Mar 28.
    Department of Obstetrics and Gynecology, University Hospitals Paris Nord Val de Seine (HUPNVS), Assistance Publique Hôpitaux de Paris (APHP), Bichat Hospital. Department Risks and Pregnancy (DHU) Paris Diderot University, Sorbonne Paris Cité, Inserm U1141. Paris, France.
    Objectives: To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease.

    Study Design: This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014. Among 280 000 births, 2288 medical records of women with thyroid dysfunction were selected and screened. Read More

    Thyroid disorders and breast cancer risk in Asian population: a nationwide population-based case-control study in Taiwan.
    BMJ Open 2018 Mar 30;8(3):e020194. Epub 2018 Mar 30.
    Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
    Objective: To evaluate whether hyperthyroidism or hypothyroidism increases the risk of subsequent breast cancer in an Asian population.

    Design: Nationwide population-based case-control study.

    Setting: All healthcare facilities in Taiwan. Read More

    Polyostotic Fibrous Dysplasia With and Without McCune-Albright Syndrome-Clinical Features in a Nordic Pediatric Cohort.
    Front Endocrinol (Lausanne) 2018 15;9:96. Epub 2018 Mar 15.
    Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
    Objective: Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Read More

    2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction.
    Eur Thyroid J 2018 Mar 14;7(2):55-66. Epub 2018 Feb 14.
    Physicians' Clinic, London, United Kingdom.
    Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH and AIT may develop in apparently normal thyroid glands or in the presence of underlying thyroid abnormalities. AIH does not require amiodarone withdrawal, and is treated with levothyroxine replacement if overt, whereas subclinical forms may be followed without treatment. Read More

    Occurrence of Graves' Orbitopathy and Graves' Hyperthyroidism after a Trauma to the Eye.
    Eur Thyroid J 2018 Jan 22;7(1):51-54. Epub 2017 Aug 22.
    Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa, Pisa, Italy.
    Background: Graves' orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes the appearance or deterioration of GO in patients with Graves' hyperthyroidism (GH), as it occurs following radioiodine treatment. In theory, a similar release of autoantigens may occur at the eye level, for example due to an orbital trauma or surgical manipulation. Read More

    Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors.
    Clin Med Insights Endocrinol Diabetes 2018 21;11:1179551418759076. Epub 2018 Mar 21.
    Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
    Background: Graves disease (GD) has increased in prevalence over the past decade in Africa. Despite this, the condition is not well described, especially in sub-Saharan Africa.

    Objective: We have described the clinical characteristics and associated factors of GD in a cohort of patients attending a resource-limited setting tertiary hospital. Read More

    Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study.
    J Clin Endocrinol Metab 2018 Mar 23. Epub 2018 Mar 23.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.

    Objective: To examine thyroid cancer risk following diagnoses of a wide range of benign thyroid conditions. Read More

    Managing thyrotoxicosis in the acute medical setting.
    Acute Med 2018 ;17(1):44-48
    MBBS MRCP (UK), Endocrine Unit, Royal Victoria Infirmary, Queen Victoria Road, Newcastle Upon Tyne, NE1 4LP UK.
    Thyrotoxicosis is common and can present in numerous ways with patients exhibiting a myriad of symptoms and signs. It affects around 1 in 2000 people annually in Europe1. The thyroid gland produces two thyroid hormones - thyroxine (T4) and triiodothyronine (T3). Read More

    Evaluation and Management of the Child with Thyrotoxicosis.
    Recent Pat Endocr Metab Immune Drug Discov 2018 Mar 26. Epub 2018 Mar 26.
    Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta. Canada.
    Background: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. Read More

    Validity and Reliability of the Korean Version of the Hyperthyroidism Symptom Scale.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):70-78
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    Background: Thyrotoxicosis is a common disease resulting from an excess of thyroid hormones, which affects many organ systems. The clinical symptoms and signs are relatively nonspecific and can vary depending on age, sex, comorbidities, and the duration and cause of the disease. Several symptom rating scales have been developed in an attempt to assess these symptoms objectively and have been applied to diagnosis or to evaluation of the response to treatment. Read More

    Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study.
    Thyroid 2018 Apr 27;28(4):537-546. Epub 2018 Mar 27.
    5 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark .
    Background: Maternal thyroid dysfunction may adversely affect fetal brain development, but more evidence is needed to refine this hypothesis. The aim of this study was to evaluate potential fetal programming by abnormal maternal thyroid function on child neurodevelopmental disorders.

    Methods: The design was a case-cohort study within the Danish National Birth Cohort (1997-2003). Read More

    Steroids and Thyrotoxicosis Precipitate Periodic Paralysis.
    Cureus 2018 Jan 23;10(1):e2106. Epub 2018 Jan 23.
    Internal Medicine, St. Joseph Mercy Oakland Hospital.
    Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. Read More

    Hip Fracture in a Patient with Primary Hyperparathyroidism: Medical and Surgical Lessons.
    Cureus 2018 Jan 23;10(1):e2104. Epub 2018 Jan 23.
    Trauma & Orthopaedics, Galway University Hospital.
    Hyperparathyroidism is a condition which can be primary, secondary or tertiary and is characterized by increased calcium levels, low phosphate levels, and elevated parathyroid hormone (PTH) levels. Primary hyperthyroidism can cause severe bone resorption leading to bone pains and pathological fracture. We present the case of a patient with severe primary hyperparathyroidism with an atraumatic fracture at the neck of the femur and multiple medical comorbidities presenting a surgical challenge. Read More

    Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports.
    World J Oncol 2018 Feb 8;9(1):1-4. Epub 2018 Mar 8.
    Jersey Shore University Medical Center, Neptune, NJ, USA.
    The utility of immunotherapy, such as pembrolizumab, is becoming essential in the treatment of certain cancers. Pembrolizumab works through binding of programmed cell death 1 receptor that blocks the binding of the programmed cell death ligand 1 and is commonly used in non-small cell lung cancer and melanoma. Pembrolizumab has been reported to be associated with multiple adverse reactions such as pneumonitis, colitis, hepatitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and type 1 diabetes; however, pembrolizumab causing type 1 diabetes was only reported in 0. Read More

    Thyrotoxic crisis as an acute clinical presentation in a child.
    BMJ Case Rep 2018 Mar 23;2018. Epub 2018 Mar 23.
    Paediatrics, University Hospitals of Leicester Foundation Trust, Leicester, UK.
    A previously well, 4-year-old girl presented with a 4-6 weeks' history of increased appetite, weight loss, tiredness, sleep difficulty, excessive sweating, swelling in the neck and new-onset 'prominent, protruding eyes.' Family history revealed paternal grandmother receiving treatment for hyperthyroidism. Clinical assessment demonstrated features of thyrotoxicosis (tachycardia, warm peripheries, small smooth goitre with no nodules, exophthalmos). Read More

    The influence of thyroid function on the coagulation system and its clinical consequences.
    J Thromb Haemost 2018 Apr 23;16(4):634-645. Epub 2018 Mar 23.
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
    Several studies indicate that low plasma levels of thyroid hormone shift the hemostatic system towards a hypocoagulable and hyperfibrinolytic state, whereas high levels of thyroid hormone lead to more coagulation and less fibrinolysis. Low levels of thyroid hormone thereby seem to lead to an increased bleeding risk, whereas high levels, by contrast, increase the risk of venous thromboembolism. Hypothyroidism leads to a higher incidence of acquired von Willebrand's syndrome and with increasing levels of free thyroxine, levels of fibrinogen, factor VIII and von Willebrand factor, amongst others, increase gradually, to the extent that they may lead to symptomatic venous thromboembolism in patients with hyperthyroidism. Read More

    Outcomes of Radiofrequency Ablation Therapy for Large Benign Thyroid Nodules: A Mayo Clinic Case Series.
    Mayo Clin Proc 2018 Mar 21. Epub 2018 Mar 21.
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To assess the effectiveness, tolerability, and complications of radiofrequency ablation (RFA) in patients with benign large thyroid nodules (TNs).

    Patients And Methods: This is a retrospective review of 14 patients with predominantly solid TNs treated with RFA at Mayo Clinic in Rochester, Minnesota, from December 1, 2013, through October 30, 2016. All the patients declined surgery or were poor surgical candidates. Read More

    Global epidemiology of hyperthyroidism and hypothyroidism.
    Nat Rev Endocrinol 2018 May 23;14(5):301-316. Epub 2018 Mar 23.
    Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
    Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common conditions with potentially devastating health consequences that affect all populations worldwide. Iodine nutrition is a key determinant of thyroid disease risk; however, other factors, such as ageing, smoking status, genetic susceptibility, ethnicity, endocrine disruptors and the advent of novel therapeutics, including immune checkpoint inhibitors, also influence thyroid disease epidemiology. Read More

    Anaemia and thyrotoxicosis: The need to look for an alternative cause.
    Clin Endocrinol (Oxf) 2018 Mar 22. Epub 2018 Mar 22.
    Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand.
    Objectives: Anaemia and thyrotoxicosis are both relatively common. It is unclear whether thyrotoxicosis results in anaemia in the absence of other causes. The aim of this study was to determine the prevalence and characteristics of anaemia in patients with thyrotoxicosis. Read More

    Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate.
    Environ Sci Technol 2018 Apr 26;52(7):4432-4439. Epub 2018 Mar 26.
    State Key Laboratory of Freshwater Ecology and Biotechnology , Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072 , China.
    Accumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about its ecological safety. However, hazardous effects of PFBS remain largely unexplored, especially for endocrine disrupting potency. In the present study, the multigenerational endocrine disrupting potential of PFBS was investigated by exposing F0 marine medaka eggs to PFBS at different concentrations (0, 1. Read More

    Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Braz J Med Biol Res 2018 Mar 15;51(5):e7196. Epub 2018 Mar 15.
    Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
    Data on the association between subclinical thyroid dysfunction and coronary artery disease (CAD) is scarce. We aimed to analyze the association between thyroid function and CAD using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (0. Read More

    Post partum and non-post partum relapsing Graves' hyperthyroidism display different response to anti-thyroid drugs.
    Eur J Endocrinol 2018 Mar 20. Epub 2018 Mar 20.
    L Chiovato, Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., University of Pavia , Pavia, Italy
    Design: Graves' disease (GD) patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown. Aim of this study was to compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not.

    Methods: We retrospectively evaluated fourty-three GD female patients in their childbearing age who experienced a relapse of hyperthyroidism. Read More

    Amiodarone-Induced Thyroid Dysfunction: A Clinical Update.
    Exp Clin Endocrinol Diabetes 2018 Mar 20. Epub 2018 Mar 20.
    Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP.
    Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Read More

    Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria.
    J Clin Res Pediatr Endocrinol 2018 Mar 19. Epub 2018 Mar 19.
    Mersin University Faculty of Medicine Department of Internal Medicine, Division of Endocrinology and Metabolism, Mersin, Turkey.
    Objective: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.

    Methods: Eighty newly diagnosed children were included into study. ESS was diagnosed in two different ways:Criteria 1; fT3 was below the lower limit, fT4 was within the normal or low limits, TSH was in normal range and in criteria 2 all the levels were same as criteria 1 but moreover rT3 was performed and was higher than normal limits. Read More

    Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature.
    Case Rep Endocrinol 2018 10;2018:4135940. Epub 2018 Jan 10.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
    Aim: To present a case of Graves' disease complicated by methimazole induced agranulocytosis treated with therapeutic plasma exchange (TPE) and review of the literature.

    Case Presentation: A 21-year-old patient with a history of Graves' disease presented to the endocrine clinic. His history was significant for heat intolerance, weight loss, and tremors. Read More

    Acute inflammatory thyromegaly following checkpoint inhibition: A new imaging entity?
    Radiol Case Rep 2018 Feb 20;13(1):89-91. Epub 2017 Oct 20.
    Department of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
    Immune checkpoint blockade (CPB) utilizing such agents as ipilimumab, nivolumab, or pembrolizumab has revolutionized melanoma therapy and has seen continued utilization in numerous other malignancies in recent years. However, these agents come at the price of inflammatory immune-related adverse events. Despite the increasing recognition of biochemical thyroid dysfunction associated with CPB, information regarding potential imaging findings is sparse. Read More

    Role of Virtual Touch Tissue Quantification in Hashimoto's Thyroiditis.
    Ultrasound Med Biol 2018 Jun 16;44(6):1164-1169. Epub 2018 Mar 16.
    Department of Ultrasound, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. Electronic address:
    We investigated the role of the virtual touch tissue quantification (VTQ) technique in diagnosing Hashimoto's thyroiditis (HT) and in distinguishing various HT-related thyroid dysfunctions. Two hundred HT patients and 100 healthy volunteers (the control group) were enrolled. The diagnostic performance of VTQ in predicting HT was calculated as the area under the receiver operating characteristic curve (A). Read More

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