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    Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
    J Med Case Rep 2017 Jun 23;11(1):173. Epub 2017 Jun 23.
    Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Background: Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management.

    Case Presentation: A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming. Read More

    A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China.
    Medicine (Baltimore) 2017 Jun;96(25):e7279
    Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    Background: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered.

    Objective: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Read More

    Risk of embryopathies with use of antithyroidal medications.
    Curr Opin Endocrinol Diabetes Obes 2017 Jul 20. Epub 2017 Jul 20.
    aDepartment of Endocrinology bDepartment of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
    Purpose Of Review: Hyperthyroidism in pregnant women should be adequately treated to prevent maternal and fetal complications. The treatment of choice in pregnancy is antithyroidal medications (ATDs). The risk of embryopathies associated with the use of Methimazole (MMI) and Propylthiouracil (PTU) in early pregnancy is a matter of clinical attention and concern. Read More

    [Diabetes mellitus secondary to an endocrine pathology : when to think about it ?]
    Rev Med Suisse 2017 May;13(565):1158-1162
    Service d'endocrinologie, diabétologie, hypertension et nutrition, HUG, 1211 Genève 14.
    An endocrine disease can be associated with glucose intolerance or diabetes mellitus, and the latter can falsely be considered as type 2 diabetes. Glycemic imbalance can be a direct or indirect consequence of excessive hormone production. Endocrine diseases such as acromegaly, Cushing's syndrome and pheochromocytoma can increase glucose production and cause insulin resistance. Read More

    Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area.
    Biomed Res Int 2017 30;2017:2390812. Epub 2017 May 30.
    Institute of Chemistry, New Campus, University of the Punjab, Lahore, Pakistan.
    Background: Association of thyroid dysfunction (TD) with interferon treatment of HCV is well known to clinicians. However, a few studies have highlighted the role of hepatitis C virus per se in the development of TD. The aim of this study was to know the prevalence of TD in non-interferon treated HCV infected patients referred for thyroid function testing. Read More

    Thyrotoxic periodic paralysis: a case study and review of the literature.
    J Community Hosp Intern Med Perspect 2017 Mar 6;7(2):103-106. Epub 2017 Jun 6.
    Department of Family Medicine, Guthrie Medical Group, PC, Sayre, PA, USA.
    Acute hypokalemic paralysis is a rare cause of acute weakness. Morbidity and mortality associated with unrecognized disease can occur and include respiratory failure and possibly death. Common causes of hypokalemic paralysis include thyrotoxic periodic paralysis (TPP) which is a disorder most frequently seen in Asian males. Read More

    Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study.
    Eur J Med Res 2017 Jun 21;22(1):21. Epub 2017 Jun 21.
    Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Research Complex, Khorram Street, Isfahan, 8187698191, Iran.
    Background: The prevalence of thyroid dysfunction is high in Isfahan, an area of iodine sufficient in Iran. The aim of this study is to investigate the incidence of thyroid dysfunctions in adults of metropolitan Isfahan and to determine the role of thyroid autoantibodies.

    Methods: In a population-based cohort study in 2006-2011, we measured TSH, T4, T3, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in 618 out of 2254 people who were euthyroid in 2006. Read More

    [Thyrotropin-producing adenomas and thyrotropic hyperplasia (clinical case reports and the review of the literature)].
    Zh Vopr Neirokhir Im N N Burdenko 2016 ;80(3):82-90
    Burdenko Neurosurgical Institute, Moscow, Russia.
    An increased blood level of the thyroid stimulating hormone (TSH) is usually associated with primary hypothyroidism (PHT) but can also be observed in such rare cases as TSH-secreting pituitary tumor. The article describes four clinical cases of elevated TSH blood levels: 1) TSH-secreting pituitary adenoma with hyperthyroidism; 2) TSH-secreting adenoma with hypothyroidism; 3) hormonally inactive pituitary adenoma combined with primary hypothyroidism; 4) reversible thyrotropic hyperplasia. These clinical situations substantiate the importance of considering different diagnoses in a patient with a pituitary gland tumor associated with an increased TSH blood level. Read More

    Transdermal Nicotine : A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy as an Aid to Smoking Cessation.
    Drugs 1992 Sep;44(3):498-529
    Adis International Limited, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand.
    Synopsis: Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows the smoker to abstain from smoking more easily. The systems are available in 16- and 24-hour application regimens, and are recommended for daily use for up to 20 weeks, including a series of weaning-off courses. Read More

    Thyrotoxic periodic paralysis as an initial presentation of Graves' disease in a Saudi patient.
    BMJ Case Rep 2017 Jun 19;2017. Epub 2017 Jun 19.
    Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Thyrotoxic periodic paralysis (TPP) is a well-known complication of hyperthyroidism, characterised by recurrent flaccid paralysis with hypokalaemia. To date, only five cases of this rare disorder have been reported in Saudi Arabia. Here, we report an additional case involving a 25-year-old Saudi man who presented with lower limb paralysis and severe hypokalaemia. Read More

    Graves' disease with severe neutropenia: any clues?
    Clin Endocrinol (Oxf) 2017 Jun 19. Epub 2017 Jun 19.
    Medical Department, Al Adan Hospital, Kuwait.
    In volume 85, issue 6 of "Clinical Endocrinology", Aggarwal, et al. published a study titled "Treatment of Hyperthyroidism With Antithyroid Drugs Corrects Mild Neutropenia in Graves' Disease". The authors treated Graves' disease (GD) with mild neutropenia using a thionamide anti-thyroid drug (ATD). Read More

    Case of Ovarian Cancer in a Woman with Undiagnosed Graves' Disease: A Case Report and Review of the Literature.
    Case Rep Oncol 2017 May-Aug;10(2):452-454. Epub 2017 May 23.
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
    Epithelial ovarian cancer (OC) is a leading cause of death among females in the United States, due in part to challenges of diagnosis in the early stages of the disease. While efforts are underway to develop a high-quality screening test, it is equally important to consider whether high-risk populations are appropriate to screen. One such population may be females with hyperthyroidism, as epidemiologic studies have shown an association between this condition and OC. Read More

    Association between giant cell arteritis and thyroid dysfunction in a "real life" population.
    Endocrine 2017 Jun 16. Epub 2017 Jun 16.
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    Purpose: Giant cell arteritis is a systemic autoimmune disorder which involves inflammation of medium to large vessels. The association between giant cell arteritis and autoimmune thyroid disorders has been investigated numerous times in the literature with inconsistent results. Our objective was to evaluate whether a genuine association exists between giant cell arteritis and thyroid dysfunction, which is often due to immune-mediated thyroid disease. Read More

    Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4].
    J Inorg Biochem 2017 Jun 1;174:76-89. Epub 2017 Jun 1.
    Centro de Química Inorgánica (CEQUINOR, CONICET, UNLP), Departamento de Química-Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Boulevard 120 entre 60 y 64, C.C.962-(B1900AVV)-1900 La Plata, Argentina. Electronic address:
    In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2[CuCl4]·½H2O and (SerH2)2[CuCl4], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. Read More

    Lugol's solution-induced painless thyroiditis.
    Endocrinol Diabetes Metab Case Rep 2017 30;2017. Epub 2017 May 30.
    Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Centre, Montreal, QuebecCanada.
    Lugol's solution is usually employed for a limited period for thyroidectomy preparation in patients with Graves' disease and for the control of severe thyrotoxicosis and thyroid storm. We describe a rare case of Lugol's solution-induced painless thyroiditis. In November 2014, a 59-year-old woman was prescribed Lugol's solution four drops per day for the alleviation of menopausal symptoms. Read More

    Growth hormone and insulin-like growth factor 1 affect the severity of Graves' disease.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Department of Medical, Oral and Biotechnological Sciences, Dental School, University 'G. d'Annunzio' of Chieti-Pescara, ChietiItaly.
    Graves' disease, the most common form of hyperthyroidism in iodine-replete countries, is associated with the presence of immunoglobulins G (IgGs) that are responsible for thyroid growth and hyperfunction. In this article, we report the unusual case of a patient with acromegaly and a severe form of Graves' disease. Here, we address the issue concerning the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in influencing thyroid function. Read More

    Study of factors that influence the outcome of (131)I treatment in hyperthyroidism secondary to nodular goitre.
    Rev Esp Med Nucl Imagen Mol 2017 Jun 12. Epub 2017 Jun 12.
    Servicio de Medicina Interna, Hospital POVISA, Vigo, España.
    Objective: To assess the outcome after (131)I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments.

    Material And Methods: A retrospective study was conducted on 108 patients (67 MNG and 41 NTG) treated in our department, with a follow-up period of at least 2 years. Development of hypothyroidism and treatment failure were evaluated along with their relationship with the administered dose and other factors such as age, sex, grade of hyperthyroidism, type of goitre, presence of autoimmunity, or previous antithyroid medication. Read More

    [Reference Intervals of Thyroid Hormones in Normal Pregnant Women and Effects of Thyroid Autoantibodies on Thyroid Hormone Levels in Pregnant Women in Chengdu Area].
    Sichuan Da Xue Xue Bao Yi Xue Ban 2017 May;48(3):450-454
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
    Objectives: To establish the reference intervals of thyroid hormones in normal pregnant women in Chengdu area of China, and to investigate the effects of thyroid autoantibodies on thyroid function in pregnant women.

    Methods: We included 696 pregnant women who had gestation data from June 2013 to March 2014 in Chengdu Women & Children's Central Hospital. Every subject under went questionnaire survey, physical examination, thyroid ultrasound and measurement of thyroid hormone and thyroid autoantibodies. Read More

    Drug Reaction with Eosinophilia and Systemic Symptom in a Patient with Pneumonia and Hyperthyroidism.
    J Res Pharm Pract 2017 Apr-Jun;6(2):130-133
    Department of Respiratory Diseases, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang, China.
    Drug rash with eosinophilia and systemic symptoms syndrome is an idiosyncratic drug reaction characterized by fever, skin eruption, lymph node enlargement, and internal organ involvement. We report a case of a patient with pneumonia who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (renal failure and eosinophilic pneumonitis) caused by methimazole. The patient improved remarkably with drug withdrawal. Read More

    Total Thyroidectomy: the first, the best. The recurrent goiter issue.
    Clin Ter 2017 May-Jun;168(3):e194-e198
    Department of Surgery and Medical and Surgical Specialties, General And Breast Surgery Unit, University of Catania.
    Background: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. Read More

    Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.
    J Vet Intern Med 2017 Jun 13. Epub 2017 Jun 13.
    Department of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
    Background: Hyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relatively greater tyrosine availability for thyroid hormone production because of limited ability to convert tyrosine to melanin pigment. However, studies investigating a potential link between coat pigmentation and risk of hyperthyroidism are limited. Read More

    Thyrotropin levels and coronary artery calcification: cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Clin Endocrinol (Oxf) 2017 Jun 13. Epub 2017 Jun 13.
    Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
    Background: There is little information about the association between thyrotropin (TSH) levels and coronary artery calcification (CAC).

    Objective: Our aim was to analyze the association between TSH quintiles and subclinical atherosclerosis measured by CAC, using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    Design: Cross-sectional study. Read More

    Perfect storm: Therapeutic plasma exchange for a patient with thyroid storm.
    J Clin Apher 2017 Jun 13. Epub 2017 Jun 13.
    Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Thyroid storm is a potentially lethal complication of hyperthyroidism with increased thyroid hormones and exaggerated symptoms of thyrotoxicosis. First-line therapy includes methimazole (MMI) or propylthiouracil (PTU) to block production of thyroid hormones as a bridge toward definitive surgical treatment. Untreated thyroid storm has a mortality rate of up to 30%; this is particularly alarming when patients cannot tolerate or fail pharmacotherapy, especially if they cannot undergo thyroidectomy. Read More

    [Therapeutic outcomes and influence factors of maximal orbital decompression in the treatment of severe dysthyroid optic neuropathy].
    Zhonghua Yan Ke Za Zhi 2017 Jun;53(6):416-423
    Institute of orbital diseases, the General Hospital of the Armed Police Force, Beijing 100039, China.
    Objective: To evaluate the effectiveness of maximal orbital decompression in treatment for severe dysthyroid optic neuropathy (DON) of thyroid associated ophthalmopathy (TAO) and predictive factors of this therapy. Methods: The group consisted of 21 patients (30 eyes) with DON. The diagnosis was based on the following criteria: Deterioration of best corrected visual acuity (VA≤0. Read More

    Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study.
    J Clin Endocrinol Metab 2017 Jun 12. Epub 2017 Jun 12.
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD.
    Context: Cardiovascular outcomes in mild thyroid dysfunction (treatment controversial) and moderate or severe dysfunction (treatment standard) remain uncertain.

    Objective: To examine cross-sectional and prospective associations of thyroid function with cardiovascular risk factors and events.

    Design: In the Atherosclerosis Risk in Communities (ARIC) Study, we measured concentrations of thyrotropin (TSH), free thyroxine (FT4), and total triiodothyronine (T3) in stored serum samples originally collected in 1990-92. Read More

    Varied immuno-related adverse events induced by immune-check point inhibitors - Nivolumab-associated psoriasiform dermatitis related with increased serum level of interleukin-6.
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(2):95-101
    Department of Dermatology, Faculty of Medicine, University of Tsukuba.
      Nivolumab is a standard recombinant antibody treatment for patients with malignant melanoma (MM), which functions as an immune checkpoint inhibitor by blocking the programmed cell death-1 (PD-1) pathway in T cells. However, it leads to various immune-related adverse events (irAEs), and also exacerbates underlying autoimmune diseases. Herein we report cases of MM with irAE. Read More

    Anti-N-Methyl-d-Aspartate receptor (NMDAR) encephalitis during pregnancy: Clinical analysis of reported cases.
    Taiwan J Obstet Gynecol 2017 Jun;56(3):315-319
    Department of Neurology, Tianjin Port Hospital, Tianjin, China.
    Objective: To analyze the clinical features of 13 pregnant patients with anti-N-Methyl-d-Aspartate receptor (NMDAR) encephalitis.

    Materials And Methods: Retrospective review of thirteen reported cases was conducted for anti-NMDAR encephalitis patients during pregnancy. The clinical data were collected from papers published in PubMed prior to 16 February 2016. Read More

    Squamous Cell Carcinoma of Oesophagus with Tracheo- Esophageal Fistula, Pulmonary Tuberculosis and Hyperthyroidism in 16 yrs Old Female.
    J Assoc Physicians India 2017 May;65(5):102-103
    Intern, Dept. of Medicine, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab.
    This case of a 16-year-old female with moderately-differentiated squamous cell carcinoma of the esophagus with tracheo-esophageal fistula, hyperthyroidism and sputum positive pulmonary tuberculosis with RNTCP Category 1 DOTS is reported because of its rarity. The patient presented with cough, vomiting, weight loss and respiratory distress. Read More

    Reliability of fine needle aspiration biopsy in large thyroid nodules.
    Turk J Surg 2017 1;33(1):10-13. Epub 2017 Mar 1.
    Clinic of General Surgery, İzmir Tepecik Training and Research Hospital, İzmir, Turkey.
    Objective: Fine needle aspiration biopsy provides one of the most important data that determines the treatment algorithm of thyroid nodules. Nevertheless, the reliability of fine needle aspiration biopsy is controversial in large nodules. The aim of this study was to evaluate the adequacy of fine needle aspiration biopsy in thyroid nodules that are four cm or greater. Read More

    Hypothyroidism In Hepatitis C Patients On Pegylated Interferon Therapy.
    J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):706-708
    Department of Medicine, PGMI/Lahore General Hospital/ Ameer-ud-Din Medical College, Lahore, Pakistan.
    Objective: Chronic hepatitis has become a major health problem all over the world especially in the third world countries. The most common cause of chronic hepatitis in Pakistan is hepatitis C which can lead Toliver cirrhosis and hepatocellular carcinoma. In Pakistan Pegylated Interferon Alpha is still corner stone of therapy for chronic hepatitis C. Read More

    Thyroid cancer post radioactive iodine treatment for hyperthyroidism (case series and review of the literature).
    Endokrynol Pol 2017 Jun 6. Epub 2017 Jun 6.
    King Hussein Medical Center Amman-Jordan.
    Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI131 treatment for hyperthyroidism and to report the index cases' characteristics and management MATERIAL AND METHODS: A cohort of 264 patients who received RAI131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996-2014) by physical exam, radiological evaluation and serial thyroid function tests.

    Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer is 1. Read More

    [Neonatal hyperthyroidism: A sometimes challenging diagnosis].
    Arch Pediatr 2017 Jul 3;24(7):622-624. Epub 2017 Jun 3.
    Clinique universitaire de néonatologie, HCE CHU de Grenoble, CS10217, 38430 Grenoble cedex 09, France; Clinique universitaire de pédiatrie, HCE CHU de Grenoble, CS10217, 38430 Grenoble cedex 09, France.
    Graves disease complicates two pregnancies out of 1000 and when it is known before pregnancy, it warrants careful monitoring of the fetus and the newborn. We report on a case of neonatal hyperthyroidism, which revealed a previously unknown maternal thyroid disease. In this situation, neonatal signs can be misinterpreted, delaying the diagnosis. Read More

    Thyroid Disease and Type 1 Diabetes in Dutch Children: A Nationwide Study (Young Dudes-3).
    J Pediatr 2017 Jun 2. Epub 2017 Jun 2.
    Princess Amalia Children's Centre, Isala, Zwolle, The Netherlands; University Medical Center and University of Groningen Postgraduate School of Medicine, University Medical Center and University of Groningen, The Netherlands.
    Objective: To investigate the prevalence of overt thyroid disease in children in The Netherlands with and without type 1 diabetes mellitus (T1DM).

    Study Design: Nationwide, retrospective cohort study in The Netherlands. Using the national registry of both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0-14 years) with a diagnosis of T1DM, or a diagnosis of hypothyroidism or hyperthyroidism in the period 2009-2011. Read More

    Hyperthyroidism, hypothyroidism and cause-specific mortality in a large cohort of women.
    Thyroid 2017 Jun 3. Epub 2017 Jun 3.
    National Institutes of Health, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, Rockville, Maryland, United States ;
    Background: The prevalence of hyperthyroidism and hypothyroidism is 0.5-4% in iodine-replete communities, but 5-10 times higher in women than men. Those conditions are associated with a broad range of metabolic disorders and cardiovascular diseases. Read More

    Differential Regulation of Monocarboxylate Transporter 8 Expression in Thyroid Cancer and Hyperthyroidism.
    Eur J Endocrinol 2017 Jun 2. Epub 2017 Jun 2.
    D Zwanziger, Department of Endocrinology and Metabolism, Universitatsklinikum Essen, Essen, 45122, Germany
    Objective: Thyroid hormone (TH) transporters are expressed in thyrocytes and most likely/putatively may play a role in TH-release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) and the L-type amino acid transporters LAT2 and LAT4 is changed with thyrocyte dedifferentiation and in hyperfunctioning thyroid tissues.

    Design And Methods: Protein expression and localization of transporters was determined by immunohistochemistry in human thyroid specimen including normal thyroid tissue (NT, n=19), follicular adenoma (FA, n=44), follicular thyroid carcinoma (FTC, n=45), papillary thyroid carcinoma (PTC, n=40), anaplastic thyroid carcinoma (ATC, n=40) and Graves' disease (GD, n=50) by calculating the 'hybrid' (H) score. Read More

    Thyrotoxicosis - investigation and management .
    Clin Med (Lond) 2017 Jun;17(3):274-277
    King's College Hospital, Denmark Hill, London
    Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Read More

    Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report.
    J Clin Diagn Res 2017 Apr 1;11(4):SD01-SD02. Epub 2017 Apr 1.
    Paediatric Consultant, Department of Paediatrics, King Saud Bin Abdulaziz University for Health Sciences, National Guard Hospital, Riyadh, Saudi Arabia.
    Neonatal hyperthyroidism is a rare disease that is seen in infants born to mothers with Graves' disease. Hepatic manifestation of neonatal hyperthyroidism is extremely rare. We describe a neonate with fulminant liver failure secondary to neonatal hyperthyroidism caused by maternal Graves's disease. Read More

    RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
    J Clin Lab Anal 2017 May 31. Epub 2017 May 31.
    Department of Otolaryngology & Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Objectives: This study was designed to unveil the association of GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 with the onset of liver damage (LD) among the Graves' disease (GD) patients.

    Methods: A total of 120 GD patients were divided into the none-LD and LD groups. Several indicators were detected for assessing liver functions, and genotypes of single nucleotide polymorphisms (SNPs) were identified. Read More

    Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid.
    Cytojournal 2017 28;14:10. Epub 2017 Apr 28.
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
    Background: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal) and Bethesda category IV (Beth-IV) thyroid follicular lesions, which carry a 15%-30% risk of malignancy and are often followed up with surgical resection. Read More

    Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse: A case report.
    Medicine (Baltimore) 2017 Jun;96(22):e7053
    aDepartment of Cardiovascular Medicine bDepartment of Therapeutic Strategy for Heart Failure cDepartment of Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Rationale: Heart failure is relatively common in patients with hyperthyroidism, but thyrotoxic cardiomyopathy with poor left ventricular (LV) systolic function is very rare.

    Patient Concerns: We experienced a representative case of a patient who presented with severe LV dysfunction related to thyroid storm and needed extracorporeal membrane oxygenation (ECMO) temporally.

    Diagnosis: Thyrotoxic cardiomyopathy. Read More

    Functional Effects of Hyperthyroidism on Cardiac Papillary Muscle in Rats.
    Arq Bras Cardiol 2016 Dec;107(6):542-549
    Laboratório de Fisiologia da Contração Muscular, Universidade Federal do Paraná, Brazil.
    Background: Hyperthyroidism is currently recognized to affect the cardiovascular system, leading to a series of molecular and functional changes. However, little is known about the functional influence of hyperthyroidism in the regulation of cytoplasmic calcium and on the sodium/calcium exchanger (NCX) in the cardiac muscle.

    Objectives: To evaluate the functional changes in papillary muscles isolated from animals with induced hyperthyroidism. Read More

    AACE Clin Case Rep 2017 ;3(2):e134-e139
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, United States.
    Objective: An asymptomatic male was found on screening to have a low serum TSH and total T4. The diagnosis of Graves' disease was made with positive thyroid stimulating immunoglobulin (TSI) and elevated free T4 in the presence of complete TBG deficiency (TBG-CD). Genetic testing of the patient and family members revealed a novel frameshift mutation in the TBG (SERPINA7) gene resulting in a complete deficiency of the protein. Read More

    Bilateral Idiopathic Sclerochoroidal Calcifications.
    Open Ophthalmol J 2017 27;11:76-79. Epub 2017 Apr 27.
    NJ Retina, Robert Wood Johnson Medical School, Rutgers RWJ - University Hospital, New Brunswick, NJ, USA.
    Background: Sclerochoroidal calcification (SCC) is a rare and benign condition found mostly in middle-aged and elderly Caucasian men, characterized by multiple yellow-white lesions seen most commonly in the temporal regions of the fundus. While they may be concerning for benign tumors, primary neoplasias or metastases, SCCs most commonly present as asymptomatic findings during routine ophthalmologic testing and have a very good prognosis as they rarely cause visual deficits.

    Objective: To report and describe the findings in a case of bilateral idiopathic sclerochoroidal calcifications. Read More

    Long-term treatment-related morbidity in differentiated thyroid cancer: a systematic review of the literature.
    Pragmat Obs Res 2017 16;8:57-67. Epub 2017 May 16.
    Department of Oncology and Metabolism.
    Background: Differentiated thyroid cancer (DTC) occurs in relatively young patients and is associated with a good prognosis and long survival. The management of this disease involves thyroidectomy, radioiodine therapy, and long-term thyroid-stimulating hormone suppression therapy (THST). The long-term effects of the treatment and the interaction between subclinical hyperthyroidism and long-term hypoparathyroidism are poorly understood. Read More

    Mitochondrial Bioenergetics During Ischemia and Reperfusion.
    Adv Exp Med Biol 2017 ;982:141-167
    Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, 1900, Buenos Aires, Argentina.
    During ischemia and reperfusion (I/R) mitochondria suffer a deficiency to supply the cardiomyocyte with chemical energy, but also contribute to the cytosolic ionic alterations especially of Ca(2+). Their free calcium concentration ([Ca(2+)]m) mainly depends on mitochondrial entrance through the uniporter (UCam) and extrusion in exchange with Na(+) (mNCX) driven by the electrochemical gradient (ΔΨm). Cardiac energetic is frequently estimated by the oxygen consumption, which determines metabolism coupled to ATP production and to the maintaining of ΔΨm. Read More

    High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function.
    Int J Hyperthermia 2017 Apr 24:1-7. Epub 2017 Apr 24.
    c Department of Radiology , The University of Hong Kong , Hong Kong SAR , PR China.
    Background: High intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. However, its effect on underlying thyroid function remains unknown. We aimed to evaluate the 6 months changes in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) after HIFU treatment. Read More

    [Value of ultrasound shear wave elasticity imaging in diagnosis of Hashimoto's thyroiditis].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 May;37(5):683-686
    Department of Ultrasound, First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China.E-mail:
    Objective: To investigate the correlation between Young's modulus of the thyroid tissue measured by in shear wave elastography (SWE) and the clinical manifestations of Hashimoto's thyroiditis in different stages.

    Methods: A total of 104 patients with the clinical diagnosis of Hashimoto's thyroiditis were enrolled in this study, including 26 with hyperthyroidism, 29 with normal thyroid function, 27 with subclinical hypothyroidism, 22 with clinical hypothyroidism, with 50 healthy volunteers serving as the healthy control group. All the subjects underwent SWE to obtain the Young's modulus value of the thyroid tissue. Read More

    A novel treatment for subclinical hyperthyroidism: a pilot study on the beneficial effects of l-carnitine and selenium.
    Eur Rev Med Pharmacol Sci 2017 May;21(9):2268-2273
    Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
    Objective: The definition itself of subclinical hyperthyroidism (SHyper) and, therefore, the therapeutic approach to patients with SHyper still remains undefined and controversial. Therefore, the interest of finding a novel and alternative therapy for SHyper has caught the attention. An observational pilot study was performed to assess the effects of l-carnitine and selenium in the management of SHyper symptoms and endocrine profile in patients affected by this disease. Read More

    Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis.
    J Endocrinol Invest 2017 May 22. Epub 2017 May 22.
    Endocrinology Department, Cesar Milstein Hospital, 951 La Rioja St, 1221, Buenos Aires, Argentina.
    Purpose: Overt hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients. Read More

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