19,985 results match your criteria Hypertensive Heart Disease


Relationship of Postpartum Levels of Cystatin and High-Sensitivity C-Reactive Protein and Duration of Lactation in Mothers with Previous Gestational Hypertension or Preeclampsia.

Breastfeed Med 2019 Mar 15. Epub 2019 Mar 15.

5 Department of General Internal Medicine, University of California Davis, Sacramento, California.

Background: Women with hypertensive disorders of pregnancy are at increased risk of cardiovascular disease in later life. We sought to determine the association between lactation and markers of maternal cardiovascular health among postpartum women with and without hypertensive disorders of pregnancy via measures of inflammation (high-sensitivity C-reactive protein [hsCRP]) and renal function (cystatin C).

Methods: This prospective cohort study enrolled primarily overweight and obese women during early pregnancy. Read More

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http://dx.doi.org/10.1089/bfm.2018.0153DOI Listing
March 2019
1 Read

Effectiveness of dietary inorganic nitrate for lowering blood pressure in hypertensive adults: a systematic review.

JBI Database System Rev Implement Rep 2019 Mar;17(3):365-389

School of Nursing, University of Mississippi Medical Center, USA.

Objective: The objective of this review was to evaluate the effectiveness of inorganic nitrate on blood pressure in hypertensive adults.

Introduction: Hypertension is associated with increased risk of morbidity and mortality in adults. Inorganic nitrate could be beneficial for lowering blood pressure and reducing cardiovascular disease risks. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003842DOI Listing

Cardiomyopathy in obesity, insulin resistance or diabetes.

J Physiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers-New Jersey Medical School, 185 South Orange Ave, Newark, NJ, 07103.

The prevalence of obesity, insulin resistance, and diabetes is increasing rapidly. Most patients with these disorders have hypertriglyceridemia and increased plasma levels of fatty acids, which are taken up and stored in lipid droplets in the heart. Intramyocardial lipids that exceed the capacity for storage and oxidation can be lipotoxic and induce non-ischemic and non-hypertensive cardiomyopathy, termed diabetic or lipotoxic cardiomyopathy. Read More

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http://dx.doi.org/10.1113/JP276747DOI Listing

Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Hypertension 2019 Mar 14:HYP0000000000000090. Epub 2019 Mar 14.

Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Read More

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http://dx.doi.org/10.1161/HYP.0000000000000090DOI Listing
March 2019
6.480 Impact Factor

Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension.

Front Neurosci 2019 25;13:93. Epub 2019 Feb 25.

Department of Neurological Surgery, Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Hypertension is the single greatest contributor to human disease and mortality affecting over 75 million people in the United States alone. Hypertension is defined according to the American College of Cardiology as systolic blood pressure (SBP) greater than 120 mm Hg and diastolic blood pressure (DBP) above 80 mm Hg measured on two separate occasions. While there are multiple medication classes available for blood pressure control, fewer than 50% of hypertensive patients maintain appropriate control. Read More

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http://dx.doi.org/10.3389/fnins.2019.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397890PMC
February 2019

High-intensity interval exercise promotes post-exercise hypotension of greater magnitude compared to moderate-intensity continuous exercise.

Eur J Appl Physiol 2019 Mar 8. Epub 2019 Mar 8.

Department of Biosciences, Federal University of São Paulo, Rua Silva Jardim, 136, Santos, SP, 11015-020, Brazil.

Purpose: Physical exercise is associated with reduced blood pressure (BP). Moderate-intensity continuous exercise (MCE) promotes post-exercise hypotension (PEH), which is highly recommended to hypertensive patients. However, recent studies with high-intensity interval exercise (HIIE) have shown significant results in cardiovascular disease. Read More

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http://dx.doi.org/10.1007/s00421-019-04114-9DOI Listing

Effect of ivabradine, a funny current inhibitor, on portal hypertensive rats.

J Chin Med Assoc 2019 Jan;82(1):19-24

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.

Background: Ivabradine is a funny current inhibitor which is administered to patients with congestive heart failure to reduce their heart rate (HR) and attenuate oxidative stress. Chronic liver diseases are characterized by portal hypertension and hyperdynamic circulation with tachycardia. The present study aimed to investigate the effect of ivabradine on portal hypertension. Read More

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http://dx.doi.org/10.1016/j.jcma.2018.06.008DOI Listing
January 2019
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A new area for the management of hyperkalaemia with potassium binders: clinical use in nephrology.

Eur Heart J Suppl 2019 Feb 26;21(Suppl A):A48-A54. Epub 2019 Feb 26.

Université de Lorraine, Inserm, Centre d'Investigations Cliniques- Plurithématique 1433, Inserm U1116, CHRU Nancy, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Association Lorraine de Traitement de l'Insuffisance Rénale, Nancy, France.

Chronic kidney disease (CKD) patients and more so CKD patients treated with renin-angiotensin-aldosterone system inhibitors (RAASi) are prone to experience hyperkalaemia, a condition associated with an increased risk of death. This represents a true dilemma in daily practice since RAASi are the cornerstones of nephroprotective and cardioprotective strategies in CKD patients, as well as in hypertensive patients with or without CKD. The recent availability in the USA and EU of the potassium-binding resin Patiromer, together with sodium zirconium cyclosilicate (SZC), which was more recently approved in the EU and the US, may lead to a paradigm shift both in the treatment of hyperkalaemia and in enabling RAASi maintenance. Read More

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http://dx.doi.org/10.1093/eurheartj/suy032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392417PMC
February 2019
1 Read

Association between statin use and perioperative mortality after aortobifemoral bypass in patients with aortoiliac occlusive disease.

J Vasc Surg 2019 Mar 2. Epub 2019 Mar 2.

Division of Vascular and Endovascular Surgery, University of California San Diego, La Jolla, Calif. Electronic address:

Objective: The benefit of statins in reducing perioperative cardiovascular events in patients undergoing suprainguinal bypass is still controversial. The purpose of this study was to evaluate the association between statin use and perioperative mortality in patients undergoing aortobifemoral bypass (ABFB) for aortoiliac occlusive disease.

Methods: We retrospectively analyzed all patients who had ABFB in the American College of Surgeons National Surgical Quality Improvement Program data set from 2011 to 2016. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.120DOI Listing
March 2019
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Health-related quality of life among rural men and women with hypertension: assessment by the EQ-5D-5L in Jiangsu, China.

Qual Life Res 2019 Mar 4. Epub 2019 Mar 4.

College of Pharmacy, Jinan University, Guangzhou, China.

Purpose: Hypertension is a major global public health problem, including rural China. However, studies examining health-related quality of life (HRQoL) for patients with hypertension have been mostly conducted in urban populations. This study aimed to use the EuroQol five-dimensional-five-level (EQ-5D-5L) and its recently developed Chinese value set to analyze HRQoL and its influencing factors among hypertensive population in rural China. Read More

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http://dx.doi.org/10.1007/s11136-019-02139-3DOI Listing

Sudden Cardiac Death in Hypertensive Patients.

Hypertension 2019 Mar 4:HYPERTENSIONAHA11912684. Epub 2019 Mar 4.

Department of Medicine, University of Perugia, Italy (M.D.F., G.R.).

In patients with hypertension, but without established cardiovascular disease, predictive factors for sudden cardiac death (SCD) remain undefined. We followed for an average of 10.3 years a cohort of 3242 initially untreated hypertensive patients without evidence of coronary or cerebrovascular heart disease at entry. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12684DOI Listing
March 2019
2 Reads

Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association.

Hypertension 2019 Mar 4:HYP0000000000000087. Epub 2019 Mar 4.

The accurate measurement of blood pressure (BP) is essential for the diagnosis and management of hypertension. This article provides an updated American Heart Association scientific statement on BP measurement in humans. In the office setting, many oscillometric devices have been validated that allow accurate BP measurement while reducing human errors associated with the auscultatory approach. Read More

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http://dx.doi.org/10.1161/HYP.0000000000000087DOI Listing

Risk of hypertension and abnormal biomarkers in the first year postpartum associated with hypertensive disorders of pregnancy among overweight and obese women.

Pregnancy Hypertens 2019 Jan 2;15:1-6. Epub 2018 Nov 2.

Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, United States.

Objectives: Hypertension and obesity are common cardiometabolic risk factors in reproductive age women. The association of hypertensive disorders of pregnancy with later-life cardiovascular disease is well-established, however, it is unknown how obesity and hypertensive disorders of pregnancy converge to accelerate development of hypertension in the postpartum period. The aim of this study was to characterize rates of sustained hypertension at one year postpartum using the new American Heart Association/American College of Cardiology Guidelines among overweight and obese women with a normotensive pregnancy or hypertensive disorder of pregnancy. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400304PMC
January 2019
1 Read

Beneficial Effects of Mesenchymal Stem Cell Delivery via a Novel Cardiac Bioscaffold on Right Ventricles of Pulmonary Arterial Hypertensive Rats.

Am J Physiol Heart Circ Physiol 2019 Mar 1. Epub 2019 Mar 1.

Mechanical Engineering, Colorado State University, United States.

Right ventricular failure (RVF) is a common cause of death in patients suffering from pulmonary arterial hypertension (PAH). The current treatment for PAH only moderately improves symptoms and RVF ultimately occurs. Therefore, it is necessary to develop new treatment strategies to protect against RV maladaptation despite PAH progression. Read More

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http://dx.doi.org/10.1152/ajpheart.00091.2018DOI Listing

A hybrid 4-item Krousel-Wood Medication Adherence Scale predicts cardiovascular events in older hypertensive adults.

J Hypertens 2019 Apr;37(4):851-859

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: There is a need for a brief, open access, self-report medication adherence scale that overcomes challenges of existing adherence tools, is associated with incident cardiovascular disease (CVD), and identifies low 'implementation' adherers to antihypertensive medications to facilitate blood pressure management.

Methods And Results: Antihypertensive medication adherence was assessed in a cohort of 1532 older hypertensive adults without prior CVD using the self-report 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4), a hybrid tool developed to predict pharmacy refill and which captures four domains of adherence behavior: self-efficacy, physical function, intentional medication-taking, and forgetfulness. The 4-item scale categorized participants as low and high adherers using scores at least 1 and less than 1, respectively. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001955DOI Listing
April 2019
2 Reads

Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Feb 28:ATVBAHA118311992. Epub 2019 Feb 28.

Heart Center and Shanghai Institution of Pediatric Congenital Heart Diseases, Shanghai Children's Medical Center, National Children's Medical Center, China (H.Z.).

Objective- Pulmonary arterial hypertension is characterized by progressive pulmonary vascular remodeling and persistently elevated mean pulmonary artery pressures and pulmonary vascular resistance. We aimed to investigate whether transthoracic pulmonary artery denervation (TPADN) attenuated pulmonary artery (PA) remodeling, improved right ventricular (RV) function, and affected underlying mechanisms. We also explored the distributions of sympathetic nerves (SNs) around human PAs for clinical translation. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311992DOI Listing
February 2019
1 Read
6.000 Impact Factor

Usefulness of Renal Autotransplantation for Radiotherapy-induced Renovascular Hypertension.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Japan.

We experienced a young woman with congestive heart failure (CHF) caused by renovascular hypertension (RVH) and subsequent hypertensive heart disease. She underwent tumor resection and intraoperative radiation therapy because of neuroblastoma at age 2. She was diagnosed with RVH and hypertensive heart disease due to radiation-induced renal artery stenosis at age 12. Read More

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http://dx.doi.org/10.2169/internalmedicine.2001-18DOI Listing
February 2019

Prognostic value of the estimated glomerular filtration rate decline in hypertensive patients without chronic kidney disease.

Am J Hypertens 2019 Feb 22. Epub 2019 Feb 22.

CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Background: Our objective of this study was to determine if rate of eGFR decline and its intensity was associated with cardiovascular risk and death in hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m2.

Methods: This study comprised 2,516 hypertensive patients who had had at least two serum creatinine measurements over a four-year period. Read More

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http://dx.doi.org/10.1093/ajh/hpz029DOI Listing
February 2019
1 Read

Hypotensive Effect of Heated Water-based Exercise in Older Individuals with Hypertension.

Int J Sports Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Physical Education, Exercise and Chronic Disease Laboratory, São Paulo State University - UNESP, School of Sciences, Campus Bauru, Bauru, Brazil.

Blood pressure (BP) and hemodynamic response to heated water-based (HEx) land-based exercise (LEx) were assessed in 15 (6 men) older hypertensives (age 66.4±4.9 yr) under pharmacological treatment. Read More

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http://dx.doi.org/10.1055/a-0828-8017DOI Listing
February 2019
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Effect of Acute Dietary Nitrate Supplementation on the Post-Exercise Ambulatory Blood Pressure in Obese Males: A Randomized, Controlled, Crossover Trial.

J Sports Sci Med 2019 Mar 11;18(1):118-127. Epub 2019 Feb 11.

Graduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.

This study aimed to verify the effect of beetroot juice on post-exercise ambulatory blood pressure (BP) in obese individuals. Fourteen non-hypertensive obese males were randomly assigned to three experimental sessions: 1) Beetroot juice with exercise (BJE, 200ml with ≈ 800mg nitrate and 40 minutes of moderate-intensity aerobic exercise at an intensity of 50% of the heart rate reserve), 2) fruit soda with exercise (FSE, 200ml of a low-nitrate drink and the same exercise session) and 3) control (CON, 200ml of water, an insignificant nitrate drink without exercise). The concentration of total nitrites and nitrates in plasma (NOx) after the drinks and the 24-hour ambulatory BP were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370953PMC
March 2019
1 Read

Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study.

PLoS One 2019 20;14(2):e0211857. Epub 2019 Feb 20.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Background: Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM.

Methods: Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211857PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382119PMC
February 2019

Prevalence and associated factors of uncontrolled blood pressure among hypertensive patients in the rural communities in the central areas in Thailand: A cross-sectional study.

PLoS One 2019 19;14(2):e0212572. Epub 2019 Feb 19.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.

Introduction: Hypertension is a common cardiovascular disease at present. Uncontrolled blood pressure leads to further complications including heart attack, stroke and chronic kidney disease. In Thailand, most of the information related to this issue is collected by hospitals or hospital-based organizations rather than at the community level. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380583PMC
February 2019
3.234 Impact Factor

Successful Management of Late-Onset Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in Kidney Transplant Recipient After Coronary Artery Bypass Graft Surgery.

Exp Clin Transplant 2019 01;17(Suppl 1):207-211

From the Nephrology Department, Hamd Al-Essa Organ Transplant Center of Kuwait, Kuwait.

Hemophagocytic syndrome combines febrile hepatosplenomegaly, pancytopenia, hypofibrinemia, and hepatic dysfunction. It is characterized by bone marrow and organ infiltration of activated, nonmalignant macrophages that phagocytize blood cells. It is rare among renal transplant recipients. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P67DOI Listing
January 2019
1 Read

Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension.

Oxid Med Cell Longev 2019 10;2019:8912768. Epub 2019 Jan 10.

Department of Experimental Medicine, Section of Pharmacology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Cardiovascular diseases frequently coexist with chronic kidney disease that constitutes a major determinant of outcome in patients with heart failure. Dysfunction of both organs is related to chronic inflammation, endothelial dysfunction, oxidative stress, and fibrosis. Widespread expression of serine protease DPP4 that degrades varieties of substrates suggests its involvement in numerous physiological processes. Read More

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http://dx.doi.org/10.1155/2019/8912768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350609PMC
January 2019
2 Reads

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats.

J Vis Exp 2019 Jan 31(143). Epub 2019 Jan 31.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital; Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University; Center for Lipid Biosciences, Kaohsiung Medical University Hospital; Lipid Science and Aging Research Center, Kaohsiung Medical University; Institute/Center of Medical Science and Technology, National Sun Yat-sen University;

For studies related to cardiovascular physiology or pathophysiology, blood pressure (BP) and electrocardiography are basic observational parameters. Research focusing on cardiovascular disease models, potential cardiovascular therapeutic targets or pharmaceutical agents requires assessment of systemic arterial pressure and heart rhythm changes. In situations where radio telemetry systems are not available or affordable, the technique of femoral artery cannulation is an alternative way to obtain intra-arterial pressure waveform recordings and systemic BP measurements. Read More

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http://dx.doi.org/10.3791/59115DOI Listing
January 2019

Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors.

Int J Cardiol 2019 May 31;282:81-87. Epub 2019 Jan 31.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.

Background And Aim: Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate whether hypertensive pregnancy disorder in first pregnancy is associated with increased subsequent risk of maternal CVD after adjustment for established CVD risk factors measured after pregnancy.

Methods And Results: A total of 20,075 women with a first delivery registered in the Medical Birth Registry of Norway (1980-2003) participated in Cohort of Norway (CONOR) health surveys a mean (standard deviation) of 10. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.097DOI Listing
May 2019
1 Read

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 02 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019
1 Read

Inequalities in the prevalence of undiagnosed hypertension among Bangladeshi adults: evidence from a nationwide survey.

Int J Equity Health 2019 Feb 15;18(1):33. Epub 2019 Feb 15.

Institute for Social Science Research, The University of Queensland, Indooroopilly, 4068, Queensland, Australia.

Background: In recent years, developing countries like Bangladesh are facing a higher burden of non-communicable diseases such as hypertension as a result of demographic transition. Prevalence of hypertension is often studied in this setting. However, evidence on undiagnosed hypertension is not widely available in the existing literature. Read More

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http://dx.doi.org/10.1186/s12939-019-0930-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377713PMC
February 2019
1 Read

[The nursing-led in-patient unit: a descriptive study of nursing care delivered].

Ig Sanita Pubbl 2018 Jul-Aug;74(4):359-376

Assegnista di ricerca in Scienze Infermieristiche, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata, Italia.

Chronic diseases require continuous healthcare that is not fully guaranteed by the Italian Health System which is more oriented towards acute care. In the Lazio region (city of Palombara Sabina), a Nursing-Led in-patient unit is present with the aim to care for patients affected by chronic diseases. The aim of this study was to describe the type of healthcare delivered by this unit. Read More

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February 2019
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Prevalence and pattern of cardiovascular-related causes of out-of- hospital deaths in Lagos, Nigeria.

Afr Health Sci 2018 Dec;18(4):942-949

College of Medicine, University of Lagos, Medicine.

Background: In developed countries 50% - 75% of deaths from cardiovascular-diseases occurs out-of-hospital. In Nigeria where patronage of orthodox health facilities is low, the impact of cardiovascular-related diseases on out-of-hospital mortality has been sparsely studied.

Objectives: To determine the prevalence and pattern of cardiovascular-related causes of out-of-hospital deaths in Lagos, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354864PMC
December 2018
4 Reads

Chronic Low-Level Vagus Nerve Stimulation Improves Long-Term Survival in Salt-Sensitive Hypertensive Rats.

Front Physiol 2019 31;10:25. Epub 2019 Jan 31.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.

Chronic hypertension (HTN) affects more than 1 billion people worldwide, and is associated with an increased risk of cardiovascular disease. Despite decades of promising research, effective treatment of HTN remains challenging. This work investigates vagus nerve stimulation (VNS) as a novel, device-based therapy for HTN treatment, and specifically evaluates its effects on long-term survival and HTN-associated adverse effects. Read More

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http://dx.doi.org/10.3389/fphys.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365472PMC
January 2019
1 Read

Major Adverse Cardiovascular Events Following Simultaneous Pancreas and Kidney Transplantation in the United Kingdom.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Renal and Pancreatic Transplantation, Manchester University NHS Foundation Trust, Manchester, U.K.

Objective: People with type 1 diabetes and kidney failure have an increased risk for major adverse cardiovascular events (MACE). Simultaneous pancreas and kidney transplantation (SPKT) improves survival, but the long-term risk for MACE is uncertain.

Research Design And Methods: We assessed the frequency and risk factors for MACE (defined as fatal cardiovascular disease and nonfatal myocardial infarction or stroke) and related nonfatal MACE to allograft failure in SPKT recipients with type 1 diabetes who underwent transplantation between 2001 and 2015 in the U. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-211
Publisher Site
http://dx.doi.org/10.2337/dc18-2111DOI Listing
February 2019
3 Reads

Prevalence and predictors of self care practices among hypertensive patients at Jimma University Specialized Hospital, Southwest Ethiopia: cross-sectional study.

BMC Res Notes 2019 Feb 14;12(1):86. Epub 2019 Feb 14.

Pharmacy Department, Jimma University, Jimma, Ethiopia.

Objective: Hypertension is a major risk factor and precursor of myocardial infarction, chronic kidney disease, heart failure and premature death. These vascular events increased costs of hypertension management. Self-care Practices were recommended to control blood pressure among hypertensive patients. Read More

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http://dx.doi.org/10.1186/s13104-019-4125-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376695PMC
February 2019
3 Reads

Comparing the Changes in Blood Pressure After Acute Exposure to Tai Chi and Walking.

Int J Exerc Sci 2019 1;12(3):77-87. Epub 2019 Jan 1.

Department of Exercise Science and Sport Studies, Springfield College, Springfield, MA, USA.

Hypertension is a major health concern throughout the United States and is a major cause of cardiovascular disease. The purpose of this study was to compare the responses of Tai Chi and walking on measures of central and peripheral cardiac mechanisms when controlling for exercise intensity. Fifteen hypertensive subjects (2 males, 13 females; age = 20. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355127PMC
January 2019

Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease.

J Echocardiogr 2019 Feb 12. Epub 2019 Feb 12.

Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.

Background: There is a need to stratify patients who may develop heart failure because of the current "heart failure pandemic". We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure.

Methods: We measured the time from the peak to end of the T wave (TpTe) as an electrophysiological parameter, and peak early diastolic mitral flow (E) and lateral annular (e') velocities as mechanical parameters in 109 patients with hypertension. Read More

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http://dx.doi.org/10.1007/s12574-019-00421-4DOI Listing
February 2019
2 Reads

Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

New Haven CT, Yale School of Medicine.

Background: Cardiovascular disease (CVD) is the leading cause of pregnancy-related death in the United States. (1) Identification of short-term indicators of cardiovascular morbidity has the potential to alter the course of this devastating disease among women. It has been established that hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease 10-30 years after delivery; however, little is known about the association of hypertensive disorders of pregnancy with cardiovascular (CV) morbidity during the delivery hospitalization. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.010DOI Listing
February 2019
2 Reads

[Long-term results of chest wall arteriovenous graft for establishing hemodialysis access].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):227-231

Department of Vascular and Endovascular Surgery, Peking University First Hospital, Beijing, 100034, P.R.China.

Objective: To explore the role of chest wall arteriovenous graft (CWAVG) for establishing hemodialysis access in patients with end-stage renal disease.

Methods: A retrospective analysis was made on the clinical data of 12 patients with end-stage renal disease who underwent CWAVG for establishing hemodialysis access between January 2014 and June 2015. There were 3 males and 9 females with an average age of 63. Read More

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http://dx.doi.org/10.7507/1002-1892.201802003DOI Listing
February 2019
1 Read

Clinical relevance of pulmonary vasculature involvement in sickle cell disease.

Br J Haematol 2019 Feb 10. Epub 2019 Feb 10.

Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Pulmonary complications are frequent in patients with sickle cell disease (SCD), but few studies have described lung pathology in SCD. We studied the lung tissue of 30 deceased SCD patients (1994-2012). Demographics, genotype, clinical characteristics, cause of death and associated conditions are presented. Read More

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http://dx.doi.org/10.1111/bjh.15795DOI Listing
February 2019
5 Reads

Relationships between blood pressure lowering therapy and cardiovascular events in hypertensive patients with coronary artery disease and type 2 diabetes mellitus: The HIJ-CREATE sub-study.

Diabetes Res Clin Pract 2019 Feb 6;149:69-77. Epub 2019 Feb 6.

Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Japan.

Objective: The effects of intensive blood pressure (BP) lowering for hypertensive patients with coronary artery disease (CAD) and diabetes mellitus on their clinical outcomes have not been fully evaluated. The aim was to explore the optimal systolic BP target in such patients in a substudy of a prospective, randomized trial.

Methods: Of a total of 2049 hypertensive patients with CAD who were enrolled in the HIJ-CREATE study, type 2 diabetes was diagnosed in 780 (38. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.031DOI Listing
February 2019
3 Reads

Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats.

Front Pharmacol 2019 23;10:18. Epub 2019 Jan 23.

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.

An association between congestive heart failure (CHF) and chronic kidney disease (CKD) results in extremely poor patient survival rates. Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, improves the survival rate in CHF induced by aorto-caval fistula (ACF) and attenuates CKD progression. This prompted us to examine if sEH inhibitor treatment would improve the outcome if both experimental conditions are combined. Read More

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http://dx.doi.org/10.3389/fphar.2019.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351500PMC
January 2019
4 Reads

Renal sympathetic denervation improves clinical outcomes in patients undergoing catheter ablation for atrial fibrillation and history of hypertension: A meta-analysis.

J Cardiovasc Electrophysiol 2019 Feb 5. Epub 2019 Feb 5.

Division of Cardiovascular diseases, Kansas City Heart Rhythm Institute, Kansas City, KS.

Background: Currently, there is limited data regarding the impact of adjunctive renal sympathetic denervation (RSDN) with pulmonary vein isolation (PVI) in hypertensive patients with atrial fibrillation (AF).

Methods: A comprehensive literature search for studies comparing RSDN + PVI vs PVI alone for AF and history of hypertension until 1 January 2019 was performed. The results were expressed as risk ratio (RR) for the categorical variables and mean difference (MD) for the continuous variables with 95% confidence intervals (CIs). Read More

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http://dx.doi.org/10.1111/jce.13868DOI Listing
February 2019
2 Reads

Antihypertensive Activity of Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat.

Evid Based Complement Alternat Med 2019 6;2019:2897867. Epub 2019 Jan 6.

Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

() is used in traditional medicine to treat many diseases including hypertension. This study aimed to evaluate the curative effects of the aqueous extract of on hypertension. Hypertension was induced in rats by oral administration of ethanol (5 g/kg/day) for five weeks. Read More

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http://dx.doi.org/10.1155/2019/2897867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339736PMC
January 2019
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Respiratory sympathetic modulation is augmented in chronic kidney disease.

Respir Physiol Neurobiol 2019 04 2;262:57-66. Epub 2019 Feb 2.

Department of Biomedical Sciences, Macquarie University, Australia. Electronic address:

Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n = 8-10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under control conditions, and during peripheral (hypoxia), and central, chemoreceptor (hypercapnia) challenge. RespSNA was increased in the LPK vs. Read More

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http://dx.doi.org/10.1016/j.resp.2019.02.001DOI Listing
April 2019
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Arterial hypertension in cancer: The elephant in the room.

Int J Cardiol 2019 Apr 28;281:133-139. Epub 2019 Jan 28.

Clinic of Cardiovascular Diseases, IRCCS San Martino Policlinic Hospital, University of Genova, Italy. Electronic address:

The great therapeutical success achieved by oncology is counterbalanced by growing evidences of cardiovascular (CV) toxicity due to many antineoplastic treatments. Cardiac adverse events may cause premature discontinuation of effective oncologic treatments or occur as late events undermining the oncologic success. Arterial hypertension is both the most common comorbidity in cancer patients and a frequent adverse effect of anticancer therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183556
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http://dx.doi.org/10.1016/j.ijcard.2019.01.082DOI Listing
April 2019
7 Reads

DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension.

Acta Physiol (Oxf) 2019 Feb 4:e13263. Epub 2019 Feb 4.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Aim: Proteins mainly expressed in normal lungs and significantly changed in lungs exposed to systemic-to-pulmonary shunts might be promising targets for pulmonary arterial hypertension induced by congenital heart diseases (PAH/CHD). This study aimed to investigate the potential role of differential screening-selected gene aberrative in neuroblastoma (DAN) in PAH/CHD.

Methods: PAH was surgically induced by the combined surgery (right pulmonary artery ligation and left cervical systemic-to-pulmonary shunt) in Sprague-Dawley (SD) rats. Read More

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http://dx.doi.org/10.1111/apha.13263DOI Listing
February 2019
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4.382 Impact Factor

Successful Renal Denervation Decreases the Platelet Activation Status in Hypertensive Patients.

Cardiovasc Res 2019 Feb 4. Epub 2019 Feb 4.

Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne.

Aims: To determine whether renal denervation (RDN) in hypertensive patients affects the platelet activation status.

Methods And Results: We investigated the effect of RDN on the platelet activation status in 41 hypertensive patients undergoing RDN. Ambulatory blood pressure (BP), plasma sympathetic neurotransmitter Neuropeptide Y, and platelet activation markers were measured at baseline, at 3 months, and 6 months after RDN. Read More

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http://dx.doi.org/10.1093/cvr/cvz033DOI Listing
February 2019
9 Reads

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis.

J Cell Mol Med 2019 Feb 1. Epub 2019 Feb 1.

Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.

Epigenetic dysregulation plays a crucial role in cardiovascular diseases. Previously, we reported that acetyltransferase p300 (ATp300) inhibitor L002 prevents hypertension-induced cardiac hypertrophy and fibrosis in a murine model. In this short communication, we show that treatment of hypertensive mice with ATp300-specific small molecule inhibitor L002 or C646 reverses hypertension-induced left ventricular hypertrophy, cardiac fibrosis and diastolic dysfunction, without reducing elevated blood pressures. Read More

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http://dx.doi.org/10.1111/jcmm.14162DOI Listing
February 2019
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TMEM16A is Implicated in the Regulation of Coronary Flow and is Altered in Hypertension.

Br J Pharmacol 2019 Feb 2. Epub 2019 Feb 2.

Vascular Biology Research Centre, Institute of Molecular and Clinical Sciences, St George's University of London, London, SW17 0RE, UK.

Background And Purpose: Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus is it important to determine the factors that regulate coronary blood flow. Ca -activated chloride channels contribute to the regulation of arterial tone; however, their role in coronary arteries is unknown. Read More

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http://doi.wiley.com/10.1111/bph.14598
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http://dx.doi.org/10.1111/bph.14598DOI Listing
February 2019
6 Reads

Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study.

Sci Rep 2019 Jan 31;9(1):1043. Epub 2019 Jan 31.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. Read More

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http://dx.doi.org/10.1038/s41598-018-37961-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355838PMC
January 2019
2 Reads