19,873 results match your criteria Hypertensive Heart Disease


Blood pressure goals in hypertensive patients with peripheral arterial disease.

Authors:
Mislav Vrsalovic

Eur Heart J Qual Care Clin Outcomes 2019 Jan 12. Epub 2019 Jan 12.

University of Zagreb School of Medicine, Zagreb, Croatia.

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http://dx.doi.org/10.1093/ehjqcco/qcz003DOI Listing
January 2019

Night-time systolic blood pressure and subclinical cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study.

Eur Heart J Cardiovasc Imaging 2019 Jan 10. Epub 2019 Jan 10.

Department of Medicine, Columbia University, PH 3-342, 622 West 168th Street, New York, NY, USA.

Aims: Although ambulatory blood pressure (BP) is a better predictor of cardiovascular outcomes than office BP, its association with subclinical cerebrovascular disease is not clarified. We investigated the associations of office and ambulatory BP values with subclinical cerebrovascular disease in a population based, predominantly elderly cohort without prior stroke.

Methods And Results: Eight hundred and twenty-eight participants underwent 24-h ambulatory BP monitoring (ABPM), 2D echocardiography and brain magnetic resonance imaging in the Cardiac Abnormalities and Brain Lesion (CABL) study. Read More

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http://dx.doi.org/10.1093/ehjci/jey221DOI Listing
January 2019

Young adult with Friedreich ataxia.

Heart 2019 Jan 15. Epub 2019 Jan 15.

CMR Unit, Bristol Heart Institute, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Clinical Introduction: A young adult with Friedreich ataxia complaining of exertional breathlessness underwent a cardiological evaluation. On physical examination, high blood pressure and a loud systolic murmur were noted. ECG showed sinus rhythm with voltage criteria for left ventricular hypertrophy (LVH) and T-wave changes in the inferolateral leads. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314387DOI Listing
January 2019

Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population.

J Am Heart Assoc 2019 Jan;8(2):e010430

1 Research Unit Hypertension and Cardiovascular Epidemiology KU Leuven Department of Cardiovascular Sciences University of Leuven Belgium.

Background Serial imaging studies in the general population remain important to evaluate the usefulness of pathophysiologically relevant biomarkers in predicting progression of left ventricular (LV) remodeling and dysfunction. Here, we assessed in a general population whether these circulating biomarkers at baseline predict longitudinal changes in LV structure and function. Methods and Results In 592 participants (mean age, 50. Read More

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http://dx.doi.org/10.1161/JAHA.118.010430DOI Listing
January 2019

Recent Advances in Imaging of Hypertensive Heart Disease.

Curr Hypertens Rep 2019 Jan 14;21(1). Epub 2019 Jan 14.

Department of Cardiology, University of Virginia, Charlottesville, VA, USA.

Purpose Of Review: To review recent advances in the imaging of hypertensive heart disease (HHD) with an emphasis on developments in the imaging of diffuse myocardial fibrosis using cardiac magnetic resonance (CMR).

Recent Findings: HHD results from long-standing hypertension and is characterized by the development of left ventricular hypertrophy and diffuse interstitial fibrosis. Diffuse fibrosis traditionally required endomyocardial biopsy to diagnose, but recent developments using T1 mapping in CMR allow for noninvasive assessment. Read More

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http://dx.doi.org/10.1007/s11906-019-0910-6DOI Listing
January 2019

Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia.

Int J Cardiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Internal Medicine (Section of Nephrology), New Haven, CT, United States of America.

Aims: We explored the relationship between inflammation, renalase an anti-inflammatory protein, and acute chest pain with coronary microvascular dysfunction (CMD).

Methods And Results: We used cardiac Rb-82 PET/CT imaging to diagnose coronary artery disease (CAD/CALC) (defect or coronary calcification) and CMD (depressed coronary flow reserve without CAD) in patients with chest pain in an emergency department (ED). Blood samples were collected pre-imaging within 24 h of ED presentation and were analyzed for renalase and inflammatory markers including C-reactive protein, interleukins, interferon gamma, tumor necrosis factor, vascular endothelial growth factor, and metalloproteinases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183669
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http://dx.doi.org/10.1016/j.ijcard.2018.12.061DOI Listing
January 2019
1 Read

Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: The SABPA study.

Hypertens Res 2019 Jan 10. Epub 2019 Jan 10.

North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa.

Inflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic peptide) are associated with hypertension and ECG left ventricular hypertrophy (ECG-LVH) is unclear. The first prospective analysis in Africa assessing these associations included a cohort of Black and White teachers (N = 338; aged 20-63 years). Read More

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http://dx.doi.org/10.1038/s41440-018-0183-5DOI Listing
January 2019

Myocardial Strain and Stiffness Parameters as a Novel Target of Antihypertensive Treatment.

Kardiologiia 2018 Nov 24;58(11):72-81. Epub 2018 Nov 24.

Pirogov Russian National Research Medical University, Russian Gerontology Clinical Research Center; A. I. Yevdokimov Moscow State University of Medicine and Dentistry.

In the review, the clinical significance of increased myocardial stiffness and strain impairment in the settings of arterial hypertension is considered. The mechanisms of increasing myocardial stiffness as a part of hypertensive heart disease are presented. Particular attention is paid to the role of the sympathetic nervous system activation as one of the triggers that induce the connective tissue alteration of cardiac interstitium. Read More

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http://dx.doi.org/10.18087/cardio.2018.11.10203DOI Listing
November 2018

Evidence for a Causal Role of the SH2B3-βM Axis in Blood Pressure Regulation.

Hypertension 2019 Feb;73(2):497-503

From the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).

Genetic variants at SH2B3 are associated with blood pressure and circulating βM (β-2 microglobulin), a well-characterized kidney filtration biomarker. We hypothesize that circulating βM is an independent risk predictor of hypertension and may causally contribute to its development. The study sample consisted of 7 065 Framingham Heart Study participants with measurements of plasma βM. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12094DOI Listing
February 2019
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Impact of early initiation of antihypertensive medications for patients with hypertension or elevated blood pressure.

J Hypertens 2019 Jan 7. Epub 2019 Jan 7.

Department of Pharmaceutical and Health Economics, School of Pharmacy, Leonard Schaeffer Center for Health Policy and Economics.

Objectives: The 2017 American College of Cardiology/American Heart Association High Blood Pressure Guidelines lowered high blood pressure (BP) threshold, recommending earlier treatment to prevent cardiovascular disease. This study estimated the impact of initiating early antihypertensive medications on the risk of acute myocardial infarction (AMI), stroke, death, and on healthcare costs in patients potentially qualifying for antihypertensive treatment under the 2017 guidelines.

Methods: High-risk patients qualifying for antihypertensive medications under the 2017 guidelines were identified using Optum data. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002014DOI Listing
January 2019

The Association of Radial Artery Pulse Wave Variables with the Pulse Wave Velocity and Echocardiographic Parameters in Hypertension.

Evid Based Complement Alternat Med 2018 2;2018:5291759. Epub 2018 Dec 2.

Basic Medical College, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

This study aims at exploring the cardiovascular pathophysiological mechanism of TCM (traditional Chinese medicine) pulse by detecting the correlation between radial artery pulse wave variables and pulse wave velocity/echocardiographic parameters. Two hundred Chinese subjects were enrolled in this study, which were grouped into health control group, hypertension group, and hypertensive heart disease group. Physical data obtained in this study contained TCM pulse images at "Guan" position of the left hand, pulse wave velocity, and echocardiographic parameters. Read More

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https://www.hindawi.com/journals/ecam/2018/5291759/
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http://dx.doi.org/10.1155/2018/5291759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304622PMC
December 2018
3 Reads

Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease.

Transl Stroke Res 2019 Jan 7. Epub 2019 Jan 7.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Active transport of microRNAs (miRNA) in extracellular vesicles (EV) occurs in disease. Circulating EV-packaged miRNAs in the serum of stroke patients were compared to stroke mimics with matched cardio- and cerebrovascular risk factors, with corroboration of results in a pre-clinical model. An unbiased miRNA microarray was performed in stroke vs. Read More

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http://dx.doi.org/10.1007/s12975-018-0682-3DOI Listing
January 2019

Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii.

Neurosci Bull 2019 Jan 7. Epub 2019 Jan 7.

Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.

Chronic intermittent hypobaric hypoxia (CIHH) is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension (RVH). In this study, RVH was induced by the 2-kidney-1-clip method (2K1C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. Read More

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http://dx.doi.org/10.1007/s12264-018-00330-zDOI Listing
January 2019

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.

Hypertension 2019 Jan 7:HYPERTENSIONAHA11811874. Epub 2019 Jan 7.

From the Cardiovascular Translational Research, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona. Spain (E.M.-M., J.I., A.F.-C., N.L.-A.).

Myocardial fibrosis is a main contributor to the development of heart failure (HF). CT-1 (cardiotrophin-1) and Gal-3 (galectin-3) are increased in HF and associated with myocardial fibrosis. The aim of this study is to analyze whether CT-1 regulates Gal-3. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11874DOI Listing
January 2019

Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.

Am J Chin Med 2019 Jan 7:1-20. Epub 2019 Jan 7.

* Cardiovascular Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

Puerarin is an isoflavonoid isolated from the root of Pueraria lobata (Gegen in Chinese) that has been widely used to treat cardiovascular and cerebrovascular diseases in China. Here, we investigated the hypotensive effects and mechanisms of puerarin in spontaneously hypertensive rats. The qPCR array technique was used to determine the expression of hypertension-related genes. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500022DOI Listing
January 2019
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Management plans for populations with normal-to-hypertensive blood pressures: risks and benefits of antihypertensive drug treatment in populations previously defined as having high-normal blood pressure.

Authors:
Sungha Park

Korean J Intern Med 2019 Jan 28;34(1):44-49. Epub 2018 Dec 28.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Recent changes in American and European guidelines on the management of arterial hypertension have caused a considerable shift in the landscape of hypertension management. The 2017 American College of Cardiology/American Heart Association/American Society of Hypertension guideline recommends an office visit blood pressure (BP) > 130/80 mmHg as the new threshold for diagnosis of hypertension, and states that the treatment goal for all hypertensive patients should be lowered to < 130/80 mmHg. In contrast, the 2018 European guideline maintains the diagnostic threshold of hypertension at 140/90 mmHg. Read More

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http://dx.doi.org/10.3904/kjim.2018.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325426PMC
January 2019

Inhibition of Platelets by Clopidogrel Suppressed Ang II-Induced Vascular Inflammation, Oxidative Stress, and Remodeling.

J Am Heart Assoc 2018 Nov;7(21):e009600

1 Department of Interventional Therapy the First Affiliated Hospital of Dalian Medical University Dalian China.

Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009600
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http://dx.doi.org/10.1161/JAHA.118.009600DOI Listing
November 2018
4 Reads

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension.

Am J Physiol Heart Circ Physiol 2019 Jan 4. Epub 2019 Jan 4.

Division of Clinical Pharmacology, Vanderbilt University Medical Center, United States.

Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is associated with the oxidative stress and induces metabolic reprograming altering mitochondrial function. We hypothesized that cigarette smoke induces cardiovascular mitochondrial oxidative stress which contributes to endothelial dysfunction and hypertension. Read More

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http://dx.doi.org/10.1152/ajpheart.00595.2018DOI Listing
January 2019
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Controversies in the 2017 ACC/AHA Hypertension Guidelines: Who Can Be Eligible for Treatments Under the New Guidelines? - An Asian Perspective.

Circ J 2018 Dec 29. Epub 2018 Dec 29.

Department of Cardiovascular Medicine, Heart Center, Gachon University Gil Medical Center.

Until the 2017 ACC/AHA Hypertension Guidelines were released, the target blood pressure (BP) for adults with hypertension (HTN) was 140/90 mmHg in most of the guidelines. The new 2018 ESC/ESH, Canadian, Korean, Japan, and Latin American hypertension guidelines have maintained the <140/90 mmHg for the primary target in the general population and encourage reduction to <130/80 if higher risk. This is more in keeping with the 2018 American Diabetes Association guidelines. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1293DOI Listing
December 2018
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Arterial hypertension in the elderly.

Authors:
Jan Filipovský

Vnitr Lek 2018 ;64(11):987-992

Hypertension is one of the most common problems at higher age and belongs to the most important cardiovascular risk factors. Subjects aged 65 years and more have typically isolated systolic hypertension with increased pulse pressure as a consequence of decreased elasticity of central arteries. With increasing age, the prevalence of cardiovascular/ renal diseases and diabetes is higher. Read More

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January 2018
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Using Cluster Analysis to Identify Subgroups of College Students at Increased Risk for Cardiovascular Disease.

J Nurs Meas 2018 Dec;26(3):470-482

University of Nebraska Medical Center College of Nursing, Lincoln, Nebraska.

Background And Purpose:  To examine the co-occurrence of cardiovascular risk factors and cluster subgroups of college students for cardiovascular risks.

Methods: A cross sectional descriptive study was conducted using co-occurrence patterns and hierarchical clustering analysis in 158 college students.

Results: The top co-occurring cardiovascular risk factors were overweight/obese and hypertension (10. Read More

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http://dx.doi.org/10.1891/1061-3749.26.3.470DOI Listing
December 2018

Masked uncontrolled hypertension: Prevalence and predictors.

Egypt Heart J 2018 Dec 22;70(4):369-373. Epub 2018 Oct 22.

Cairo University, Cairo, Egypt.

Background: There are limited data on 'masked uncontrolled hypertension' (MUCH) in patients with treated and apparently well-controlled BP is unknown.

Objectives: To define the prevalence and predictors of MUCH among hypertensive patients with controlled office blood pressure.

Methods: One hundred ninety-nine hypertensive patients presented to the specialized hypertension clinics at two University Hospitals. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303486PMC
December 2018

Heart diseases and echocardiography in rural Tanzania: Occurrence, characteristics, and etiologies of underappreciated cardiac pathologies.

PLoS One 2018 26;13(12):e0208931. Epub 2018 Dec 26.

St. Francis Referral Hospital, Ifakara, United Republic of Tanzania.

Background: Little is known about heart diseases and their treatment in rural sub-Saharan Africa. This study aimed to describe the occurrence, characteristics, and etiologies of heart diseases, and the medication taken before and prescribed after echocardiography in a rural referral Hospital in Tanzania.

Methods: This prospective descriptive cohort study included all adults and children referred for echocardiography. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208931PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306243PMC
December 2018
1 Read

Daily urinary sodium and potassium excretion in Chinese first-generation migrants in Italy.

Int J Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Dept. Experimental and Clinical Medicine, University of Florence, Italy.

Background: China has one of the highest salt intake levels in the world, and Chinese people form one of the largest foreign-born communities now living in Europe. The present study was performed to assess 24-hour urinary sodium and potassium excretion in Chinese migrants in Italy and to explore possible associations with hypertension, hypertension awareness, and length of residence in Italy.

Methods: A cross-sectional evaluation was conducted on 319 first-generation Chinese migrants (154 women and 165 men) aged 18-70 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183420
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http://dx.doi.org/10.1016/j.ijcard.2018.12.029DOI Listing
December 2018
5 Reads

GENDER DISPARITIES OF CIRCULATORY DISEASE PROGRESS IN THE CHORNOBYL ACCIDENT CLEAN-UP WORKERS AND PHOSPHODIESTERASE 4D GENE rs966221 POLYMORPHISM.

Probl Radiac Med Radiobiol 2018 Dec;23:263-282

State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine.

Objective: Evaluation of the hypertensive disease (HD) and coronary heart disease (CHD) progress in the ChornobylNPP (ChNPP) accident clean-up workers (ACUW) and persons not exposed to ionizing radiation depending on gen-der and genotype of the phosphodiesterase 4D (PDE4D) gene rs966221 polymorphism.

Materials And Methods: There were male ACUW (ACUWm; n=515) and female ACUW (ACUWf; n=145) involved in thestudy since 2013 till 2018. Participation in the clean-up works took place in 1986-1987. Read More

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http://dx.doi.org/10.33145/2304-8336-2018-23-263-282DOI Listing
December 2018

Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease.

J Pathol 2018 Dec 23. Epub 2018 Dec 23.

Departament de Bioquímica i Biologia Molecular. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.

Fibroblast growth factor-21 (FGF21) is an endocrine factor that contributes to multiple pathophysiological processes, mainly via its action as a metabolic regulator and cardioprotective agent. Recent studies have shown increased circulating FGF21 levels in hypertensive patients and in mouse models of hypertension. However, the relevance of FGF21 in hypertensive heart disease has not been addressed. Read More

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http://dx.doi.org/10.1002/path.5226DOI Listing
December 2018

Association of Post-Traumatic Stress Disorder Symptoms Following Hurricane Katrina With Incident Cardiovascular Disease Events Among Older Adults With Hypertension.

Am J Geriatr Psychiatry 2018 Nov 25. Epub 2018 Nov 25.

Department of Medicine, Tulane University School of Medicine (ZL, EP, MK), New Orleans; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine (ZL, MK), New Orleans; San Mateo County Behavioral Health and Recovery Services (ZL), San Mateo, CA; Department of Public Health Sciences, Stritch School of Medicine, Loyola University (CJ), Chicago; Ochsner Clinic Foundation (EDF, RNR, MK), New Orleans; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham (PM), Birmingham, AL. Electronic address:

Objective: To determine the association of post-traumatic stress disorder (PTSD) symptoms following Hurricane Katrina with incident cardiovascular disease (CVD) events in older, hypertensive, community-dwelling adults both overall and stratified by age, sex, and race.

Methods: This was a prospective cohort study performed in Southeastern Louisiana 12-24 months following Hurricane Katrina through February 2011. Participants were community-dwelling older adults (n = 2,073) enrolled in the Cohort Study of Medication Adherence Among Older Adults with no known history of CVD events. Read More

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http://dx.doi.org/10.1016/j.jagp.2018.11.006DOI Listing
November 2018

Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus.

Int J Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Objective: Sustained hypertension is a major cause of heart failure in aging hypertensive patients. Salusin β, a novel bioactive peptide of 20 amino acids, has been reported to participate in various cardiovascular diseases, including hypertension. We therefore hypothesized that central knockdown of salusin β might be effective for hypertension-induced heart failure treatment. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.12.020DOI Listing
December 2018

25-Year trends in hypertension prevalence, awareness, treatment, and control in an Indian urban population: Jaipur Heart Watch.

Indian Heart J 2018 Nov - Dec;70(6):802-807. Epub 2017 Nov 13.

University of California San Francisco, Fresno, USA.

Objectives: We evaluated trends in hypertension prevalence, awareness, treatment and control in an Indian urban population over 25 years. Trends were projected to year 2030 to determine attainment of World Health Organization (WHO) Global Monitoring Framework targets.

Methods: Adult participants (n=7440, men 4237, women 3203) enrolled in successive population based studies in Jaipur, India from years 1991 to 2015 were evaluated for hypertension prevalence, awareness, treatment and control. Read More

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http://dx.doi.org/10.1016/j.ihj.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306304PMC
January 2019

Hypertensive Diseases of Pregnancy Increase Risk of Readmission With Heart Failure: A National Readmissions Database Study.

Mayo Clin Proc 2018 Dec 18. Epub 2018 Dec 18.

Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL. Electronic address:

Objective: To study the association between hypertensive diseases of pregnancy and immediate postpartum development of heart failure in a large national database.

Patients And Methods: Using the 2013 to 2014 National Readmissions Database, which covered admissions from January 1 through September 30 in years 2013 and 2014, we examined 90-day readmission rates in parturients with a diagnosis of hypertensive disease of pregnancy who were discharged after delivery. The primary outcome was the association between the presence of hypertensive disease of pregnancy and readmission with heart failure within 90 days of delivery discharge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183068
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http://dx.doi.org/10.1016/j.mayocp.2018.08.032DOI Listing
December 2018
2 Reads

Renal Artery Denervation Due to Refractory Hypertension in a Patient After Kidney Transplantation-3 Years of Observation: A Case Report.

Transplant Proc 2018 Dec 12;50(10):3946-3949. Epub 2018 Mar 12.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland. Electronic address:

Introduction: Hypertension is prevalent in most patients after renal transplantation, and it is the main factor contributing to cardiovascular diseases that cause death of a significant number of these patients. Up to 95% of patients after transplantation have hypertension, and among them are patients with refractory hypertension. Elevated blood pressure is one of the causes of deterioration of transplant function and may accelerate transplant loss. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.023DOI Listing
December 2018

Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6):1539-1544

Department of Vasculocardiology, The Third People's Hospital of Linyi City, Linyi, Shandong, China.

The aim of this work was to investigate the correlation between methylation of F2RL3 gene and coronary heart disease (CHD) with or without hypertension, secondary cardiovascular events and mortality. Sixty patients with CHD who underwent a cardiovascular rehabilitation program were recruited. Group A included 30 patients with hypertension and CHD, and group B included 30 patients with non-hypertensive CHD, followed-up for more than 8 years. Read More

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December 2018

Elevated Wall Tension Leads to Reduced miR-133a in the Thoracic Aorta by Exosome Release.

J Am Heart Assoc 2019 Jan;8(1):e010332

1 Division of Cardiothoracic Surgery Department of Surgery Medical University of South Carolina Charleston SC.

Background Reduced miR-133a was previously found to be associated with thoracic aortic ( TA ) dilation, as seen in aneurysm disease. Because wall tension increases with vessel diameter (Law of Laplace), this study tested the hypothesis that elevated tension led to the reduction of miR-133a in the TA . Methods and Results Elevated tension (1. Read More

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http://dx.doi.org/10.1161/JAHA.118.010332DOI Listing
January 2019

Thirty-Day Readmissions After Hospitalization for Hypertensive Emergency.

Hypertension 2019 Jan;73(1):60-67

Brigham and Women's Hospital Heart and Vascular Center, Boston, MA (M.V., D.L.B.).

Hypertensive emergency is a clinical entity with potentially serious health implications and high healthcare utilization. There is a lack of nationally representative data on incidence, causes, and predictors of 30-day readmission after hospitalization for hypertensive emergency. We used the 2013 to 2014 Nationwide Readmissions Database to identify index hospitalizations for hypertensive emergency. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310036PMC
January 2019
3 Reads

Immunoproteasome Subunit β5i Promotes Ang II (Angiotensin II)-Induced Atrial Fibrillation by Targeting ATRAP (Ang II Type I Receptor-Associated Protein) Degradation in Mice.

Hypertension 2019 Jan;73(1):92-101

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, China (Q.-Y. L., X.-H.Y., H.-H.L.).

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and increases the risk of stroke, heart failure, and death. Ang II (angiotensin II) triggers AF, mainly through stimulation of the AT1R (Ang II type I receptor). The immunoproteasome is a highly efficient proteolytic machine derived from the constitutive proteasome, but the role it plays in regulating AT1R activation and triggering AF remains unknown. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11813DOI Listing
January 2019
3 Reads

Out-of-Clinic Sympathetic Activity Is Increased in Patients With Masked Uncontrolled Hypertension.

Hypertension 2019 Jan;73(1):132-141

From the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease (M.S., T.D., S.O., D.A.C.), University of Alabama at Birmingham.

Masked uncontrolled hypertension (MUCH) is defined as controlled automated office blood pressure (BP; AOBP <135/85 mm Hg) in-clinic in patients receiving antihypertensive medication(s) but uncontrolled BP out-of-clinic by 24-hour ambulatory BP monitoring (ABPM; awake ≥135/85 mm Hg). We hypothesized that MUCH patients have greater out-of-clinic sympathetic activity compared with true controlled hypertensives. Patients being treated for hypertension were prospectively recruited after 3 or more consecutive clinic visits. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309788PMC
January 2019

Prenatally Diagnosed Ventricular Inversion, Restrictive Ventricular Septal Defect, Pulmonary Stenosis, Hypertensive Left Ventricle and Double Outlet Right Ventricle: Case Report and Literature Review.

Pediatr Cardiol 2018 Dec 19. Epub 2018 Dec 19.

Division of Pediatric Cardiology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

We herein describe, for the first time, the fetal presentation of a case of ventricular inversion, restrictive ventricular septal defect, pulmonary stenosis, hypertensive left ventricle and double outlet right ventricle at 34 weeks of gestational age. Postnatal echocardiography confirmed the prenatal diagnosis. The patient was subsequently successfully palliated with a left ventricle to pulmonary artery conduit. Read More

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http://dx.doi.org/10.1007/s00246-018-2048-8DOI Listing
December 2018

A Novel Angiotensin II-Induced Long Noncoding RNA Giver Regulates Oxidative Stress, Inflammation, and Proliferation in Vascular Smooth Muscle Cells.

Circ Res 2018 Dec;123(12):1298-1312

From the Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute (S.D., E.Z., P.S., V.A., M.A.R., K.S., A.L., L.L., M.W., Z.C., M.K., H.J.O., R.N.), Beckman Research Institute of City of Hope, Duarte, CA.

Rationale: AngII (angiotensin II)-mediated vascular smooth muscle cell (VSMC) dysfunction plays a major role in hypertension. Long noncoding RNAs have elicited much interest, but their molecular roles in AngII actions and hypertension are unclear.

Objective: To investigate the regulation and functions of a novel long noncoding RNA growth factor- and proinflammatory cytokine-induced vascular cell-expressed RNA ( Giver), in AngII-mediated VSMC dysfunction. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309807PMC
December 2018
11.019 Impact Factor

Total serum cholinesterase activity predicts hemodynamic changes during exercise and associates with cardiac troponin detection in a sex-dependent manner.

Mol Med 2018 12 18;24(1):63. Epub 2018 Dec 18.

Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv, 64239, Israel.

Background: Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought to evaluate parasympathetic dysfunction by measuring serum cholinesterase activity and to determine its relationship to high sensitive cardiac troponin T (hs-cTnT) as well as traditional non-invasive parameters of ANS function during exercise in apparently healthy individuals. Read More

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https://molmed.biomedcentral.com/articles/10.1186/s10020-018
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http://dx.doi.org/10.1186/s10020-018-0063-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299630PMC
December 2018
3 Reads

Prevalence and factors associated with fast resting heart rate in hypertensive and normotensive patients.

Clin Exp Hypertens 2018 Dec 19:1-8. Epub 2018 Dec 19.

a State Key Laboratory of Cardiovascular Disease, Department of Cardiology , Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

Background: Fast resting heart rate (RHR) is easily neglected in clinical practice of hypertension treatment.

Aims: We aimed to investigate the prevalence of fast RHR and associated factors in hypertensive and normotensive individuals.

Methods: We retrospectively analyzed data from two cross-sectional studies conducted in China. Read More

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http://dx.doi.org/10.1080/10641963.2018.1557681DOI Listing
December 2018

Dietary flaxseed: what we know and don't know about its effects on cardiovascular disease.

Can J Physiol Pharmacol 2018 Dec 18:1-7. Epub 2018 Dec 18.

a Canadian Centre for Agri-food Research in Health and Medicine, Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada.

Flaxseed (Linum usitatissimum) is composed of a unique combination of bioactive components that appear to generate, through either an isolated or a synergistic action, a significant beneficial effect on the cardiovascular system. With a significant increase in the generation of data on the dietary impact of flaxseed on the cardiovascular system, a review of where we stand - what we know and what we still need to understand about these effects on the heart and the vasculature - was thought to be of value and the rationale for this paper. For example, although we now know how to deliver the bioactives most efficiently (oil versus ground seed versus whole seed), we do not know how different foods can influence that delivery. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0547DOI Listing
December 2018

Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study.

Blood Press 2018 Dec 18:1-8. Epub 2018 Dec 18.

b Department of Hypertension , Institute of Cardiology , Warsaw , Poland.

Purpose: Smoking was identified as a potential factor contributing to fibromuscular dysplasia (FMD). To evaluate the prevalence of smoking and clinical characteristics in FMD subjects.

Material And Methods: We analysed 190 patients with confirmed FMD in at least one vascular bed. Read More

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http://dx.doi.org/10.1080/08037051.2018.1514252DOI Listing
December 2018
1.605 Impact Factor

Average Aortic Valve Sclerosis Score Index as a Marker for Significant Coronary Artery Disease in Patients with Non-ST-Elevation Myocardial Infarction or Unstable Angina.

J Heart Valve Dis 2018 Jan;27(1):1-8

Student Research Committee, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Previous studies have reported an association between aortic valve sclerosis (AVS) and coronary atherosclerosis. However, the threshold of sclerosis used to identify high-risk patients has not yet been determined.

Methods: A total of 225 patients admitted with non- ST-elevation myocardial infarction (NSTEMI) or unstable angina was studied. Read More

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January 2018
6 Reads

Drug Compliance and Its Associated Factors Among Hypertensive Patients in Pakistan: A Cross-sectional Study.

Hosp Pharm 2018 Dec 8;53(6):389-392. Epub 2018 Mar 8.

Dow Institute of Medical Technology, Dow University of health Sciences, Karachi, Pakistan.

The drug compliance and its associated factors were investigated among hypertensive patients attending the outpatient department of National Institute of Cardiovascular Disease (NICVD), Karachi, from September 2014 to March 2015. Data were collected retrospectively from 300 hypertensive patients taken treatment for >1 year. Half of the patients (51%) were >55 years of age with the predominance of males (52. Read More

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http://dx.doi.org/10.1177/0018578718758971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293387PMC
December 2018

Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.09.050DOI Listing
December 2018
4 Reads

Implementing vernakalant: a novel approach to cardioversion.

Authors:
Angela Hall

Emerg Nurse 2018 Dec 11. Epub 2018 Dec 11.

Jersey General Hospital, St Helier, Jersey.

Atrial fibrillation (AF) is the most common arrhythmia, and there is a one in four lifetime risk of developing the condition for people who are over the age of 40. Vernakalant, a new addition to intravenous antiarrhythmic drugs for cardioversion of AF, is the first atrial-specific antiarrhythmic drug for pharmacological cardioversion of recent onset AF and is more effective than placebo and amiodarone. The drug offers patients an alternative to other pharmacological agents for chemical cardioversion and avoids the risks associated with electrical cardioversion. Read More

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http://dx.doi.org/10.7748/en.2018.e1902DOI Listing
December 2018
2 Reads

Preschool children's physical activity and cardiovascular disease risk: A systematic review.

J Sci Med Sport 2018 Nov 28. Epub 2018 Nov 28.

Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Science, Australia. Electronic address:

Objectives: Higher physical activity (PA) levels in adults are associated with lower cardiovascular disease risk, however it is unclear whether this association is evident in children younger than five years. Given that cardiovascular disease has early life origins, this study systematically reviews evidence of associations between PA and cardiovascular disease risk factors among children aged 3-5.5years. Read More

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http://dx.doi.org/10.1016/j.jsams.2018.11.021DOI Listing
November 2018

Texture analysis of cardiovascular magnetic resonance cine images differentiates aetiologies of left ventricular hypertrophy.

Clin Radiol 2018 Oct 24. Epub 2018 Oct 24.

Bart's Heart Centre, London, UK; Institute of Cardiovascular Science, University College London, UK.

Aim: To investigate whether unenhanced cardiovascular magnetic resonance (CMR) balanced steady state free precession (bSSFP) cine images could be analysed using textural analysis (TA) software to differentiate different aetiologies of disease causing increased myocardial wall thickness (left ventricular hypertrophy [LVH]) and indicate the severity of myocardial tissue abnormality.

Materials And Methods: A mid short axis unenhanced cine frame of 216 patients comprising 50 cases of hypertrophic cardiomyopathy (HCM; predominantly Left ventricular outflow tract obstruction [LVOTO] subtype), 52 cases of cardiac amyloid (CA; predominantly AL: light chain subtype), 68 cases of aortic stenosis (AS), 15 hypertensive patients with LVH (HTN+LVH), and 31 healthy volunteers (HV) underwent TA of the CMR cine images (CMRTA) using TexRAD (TexRAD Ltd, Cambridge, UK). Among the HV, 16/31 were scanned twice to form a test-retest reproducibility cohort. Read More

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http://dx.doi.org/10.1016/j.crad.2018.09.016DOI Listing
October 2018

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients.

Rom J Intern Med 2018 Dec;56(4):257-264

Kharkiv National Medic University, Nauky Ave., Kharkiv, Ukraine.

Introduction: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. Read More

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https://content.sciendo.com/view/journals/rjim/56/4/article-
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http://dx.doi.org/10.2478/rjim-2018-0018DOI Listing
December 2018
7 Reads

Association of Adverse Pregnancy Outcomes With Self-Reported Measures of Sleep Duration and Timing in Women Who Are Nulliparous.

J Clin Sleep Med 2018 Dec 15;14(12):2047-2056. Epub 2018 Dec 15.

Department of Obstetrics and Gynecology Medicine, Northwestern University, Chicago, Illinois.

Study Objectives: To examine the relationship of self-reported sleep during pregnancy with adverse pregnancy outcomes. A secondary objective was to describe the concordance between self-reported and objectively assessed sleep during pregnancy.

Methods: In this prospective cohort, women completed a survey of sleep patterns at 6 to 13 weeks' gestation (visit 1) and again at 22 to 29 weeks' gestation (visit 3). Read More

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http://dx.doi.org/10.5664/jcsm.7534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287730PMC
December 2018
7 Reads