21,046 results match your criteria Hypertensive Heart Disease


Cardiac magnetic resonance-derived fibrosis, strain and molecular biomarkers of fibrosis in hypertensive heart disease.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Cardiovascular Unit, ASCIRES Medical Group, Valencia.

Aims: Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biomarkers of fibrosis have been related with clinical outcomes and histologically proven myocardial fibrosis. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002504DOI Listing

High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.

Objective: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002497DOI Listing

The U-shaped association between achieved blood pressure and risk of cardiovascular events and mortality in elderly and younger patients.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Department of Internal Medicine, College of Medicine, Chungbuk National University, Korea.

Objective: The main objective is to assess the appropriate level of achieved SBP and DBP to prevent cardiovascular events.

Methods: We used the National Sample Cohort from the National Health Insurance Service in Korea and analyzed data of 44 462 hypertensive patients aged 20--84 years. Achieved SBP and DBP were categorized according to average achieved SBP (<120, 120-129, 130-139, 140-149, and ≥150 mmHg) and DBP (<70, 70-79, 80-89, 90-99, and ≥100 mmHg). Read More

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http://dx.doi.org/10.1097/HJH.0000000000002434DOI Listing

Treatment with ACE inhibitors or ARBs and risk of severe/lethal COVID-19: a meta-analysis.

Heart 2020 Jul 1. Epub 2020 Jul 1.

Department of Medical Sciences, University of Ferrara, Ferrara, Emilia-Romagna, Italy

Objective: It has been hypothesised that the use of ACE inhibitors and angiotensin receptor blockers (ARBs) might either increase or reduce the risk of severe or lethal COVID-19. The findings from the available observational studies varied, and summary estimates are urgently needed to elucidate whether these drugs should be suspended during the pandemic, or patients and physicians should be definitely reassured. This meta-analysis of adjusted observational data aimed to summarise the existing evidence on the association between these medications and severe/lethal COVID-19. Read More

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http://dx.doi.org/10.1136/heartjnl-2020-317336DOI Listing

Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis.

J Rheumatol 2020 Jul 1. Epub 2020 Jul 1.

From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail:

Objective: Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties using ultrasound to calculate β stiffness index (indicating arterial stiffness) and, a more recently developed technique, two-dimensional (2D) speckle tracking strain (indicating arterial motion and deformation, strain) to 1) compare with age- and sex-matched controls and to 2) analyze relationships between strain and stiffness with disease characteristics and traditional risk factors for CVD in AS patients.

Methods: In this cross-sectional study, a cohort of 149 patients with AS, mean age 55. Read More

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http://dx.doi.org/10.3899/jrheum.200146DOI Listing

Natriuretic peptides and neprilysin inhibition in hypertension and hypertensive organ damage.

Authors:
Johji Kato

Peptides 2020 Jun 28:170352. Epub 2020 Jun 28.

Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Cardiovascular Medicine, University of Miyazaki Hospital, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. Electronic address:

The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions and pathophysiological roles of NPs in a wide range of diseases including hypertension and heart failure. These studies revealed that ANP and BNP are hormones secreted from the heart into the blood stream in response to pre- or after-load, counteracting blood pressure (BP) elevation and fluid retention through specific receptors. Read More

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http://dx.doi.org/10.1016/j.peptides.2020.170352DOI Listing

An artificial neural network approach for predicting hypertension using NHANES data.

Sci Rep 2020 Jun 30;10(1):10620. Epub 2020 Jun 30.

Department of Computer Science, Oviedo University, C/ Federico Garca Lorca, 33007, Oviedo, Spain.

This paper focus on a neural network classification model to estimate the association among gender, race, BMI, age, smoking, kidney disease and diabetes in hypertensive patients. It also shows that artificial neural network techniques applied to large clinical data sets may provide a meaningful data-driven approach to categorize patients for population health management, and support in the control and detection of hypertensive patients, which is part of the critical factors for diseases of the heart. Data was obtained from the National Health and Nutrition Examination Survey from 2007 to 2016. Read More

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http://dx.doi.org/10.1038/s41598-020-67640-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327031PMC

Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, and DZHK Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). Read More

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http://dx.doi.org/10.3390/jcm9062016DOI Listing

Changes in the number of mast cells, expression of fibroblast growth factor-2 and extent of interstitial fibrosis in established and advanced hypertensive heart disease.

Ann Anat 2020 Jun 27:151564. Epub 2020 Jun 27.

Department of Anatomy, Histology and Embryology, Medical University of Sofia, Bulgaria.

Introduction: An increasing number of studies have shed light on the role of cardiac mast cells in the pathogenesis of hypertension-induced myocardial remodeling. Mast cells promote fibroblast activation, myofibroblast differentiation and subsequent collagen accumulation through the action of tryptase, chymase, histamine and fibroblast growth factor-2. The aim of the present study was to report on the changes in the number of mast cells as evaluated through toluidine blue, tryptase and c-kit staining, to assess the extent of interstitial fibrosis and correlate it with the changes in the number of mast cells and to analyze the immunohistochemical expression of fibroblast growth factor-2 in two groups of spontaneously hypertensive rats indicative of established and advanced hypertensive heart disease. Read More

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http://dx.doi.org/10.1016/j.aanat.2020.151564DOI Listing
June 2020
2.075 Impact Factor

[Antihypertensive therapy in men and women in real clinical practice according to the National register].

Ter Arkh 2019 Sep 15;91(9):88-100. Epub 2019 Sep 15.

Myasnikov Institute of Clinical Cardiology, National Medical Research Center of Cardiology.

Hypertension is one of the most important risk factors for cardiovascular diseases (CVD) in the world, including Russia. Current Guidelines for the management of arterial hypertension do not include different theatment strategies for men and women. Gender and age analysis of antihypertensive treatmen in men and women could reveal unreasonable and non - optimal treatment in each group. Read More

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http://dx.doi.org/10.26442/00403660.2019.09.000356DOI Listing
September 2019

Diastolic function of the left and right ventricles of the heart in outpatients with arterial hypertension.

Echocardiography 2020 Jun 28. Epub 2020 Jun 28.

Department of Biochemistry, Ural State Medical University, Ekaterinburg, Russia.

Aim: The aim of the study is to investigate the impairment of diastolic function of the left ventricle (LV) and the right ventricle (RV) in arterial hypertension outpatients.

Materials And Methods: Arterial hypertension patients (n = 299) and practically healthy people (n = 62) were examined on an outpatient basis. Echocardiographically, diastolic dysfunctions of both ventricles were evaluated. Read More

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http://dx.doi.org/10.1111/echo.14781DOI Listing

Undiagnosed adult congenital heart disease presenting with postpartum dyspnoea: a case report.

ESC Heart Fail 2020 Jun 25. Epub 2020 Jun 25.

Department of Cardiology, AZ Nikolaas General Hospital, Moerlandstraat 1, Sint-Niklaas, B-9100, Belgium.

Patients with adult congenital heart disease are born with structural heart defects who survived into adulthood. Occasionally, complex lesions remain undiagnosed, potentially causing substantial cardiovascular health problems at young age. Here, the case is presented of a patient with subacute heart failure 1 week postpartum, revealing the diagnosis of aortic coarctation (CoA) with patent ductus arteriosus (PDA). Read More

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http://dx.doi.org/10.1002/ehf2.12868DOI Listing

Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study.

Ann Clin Transl Neurol 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Objective: Cerebral microbleeds (CMBs) are associated with higher risk of stroke and dementia, predating clinical diagnosis by several years. CMB are considered markers of cerebral small vessel disease (CSVD): hypertensive (deep CMB) and cerebral amyloid angiopathy (lobar CMB). We related plasma β-Amyloid (40, 42 and their ratio), clusterin, and tau levels to CMB to elucidate their role as biomarkers for the angiopathies represented by CMB. Read More

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http://dx.doi.org/10.1002/acn3.51066DOI Listing

Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township.

ESC Heart Fail 2020 Jun 25. Epub 2020 Jun 25.

Department of Medicine, University of Cape Town, Cape Town, South Africa.

Aims: Efforts to improve access to antiretroviral therapy (ART) have shifted morbidity and mortality among persons living with HIV (PLWH) from AIDS to non-communicable diseases, such as cardiovascular disease (CVD). However, contemporary data on CVD among PLWH in sub-Saharan Africa in the current ART era are lacking. The aim of this study was to assess the burden of cardiac stress among PLWH in South Africa via measurement of N-terminal prohormone of brain natriuretic peptide (NT-proBNP). Read More

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http://dx.doi.org/10.1002/ehf2.12849DOI Listing

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R.

Front Physiol 2020 9;11:625. Epub 2020 Jun 9.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background/aim: Hypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating cardiovascular diseases. However, the role of the immunoproteasome LMP10 (β2i) catalytic subunit in the regulation of angiotensin II (Ang II)-induced cardiac hypertrophic remodeling remains unclear. Read More

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http://dx.doi.org/10.3389/fphys.2020.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296172PMC

Association Between Blood Lead Level and Uncontrolled Hypertension in the US Population (NHANES 1999-2016).

J Am Heart Assoc 2020 Jun 23:e015533. Epub 2020 Jun 23.

Environmental Research Center Duke Kunshan University Kunshan China.

Background This study aims to explore whether higher blood lead levels (BLL) may be associated with failure to control blood pressure and subsequent uncontrolled hypertension. Methods and Results We used serial cross-sectional waves of the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. 30 762 subjects aged 20 years and above were included. Read More

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http://dx.doi.org/10.1161/JAHA.119.015533DOI Listing

Sensitivity and Specificity of Bedside Qualitative Troponin I Test Kit as Compared with the Standardized Quantitative Lab Test for Troponin I.

Cureus 2020 May 19;12(5):e8201. Epub 2020 May 19.

Cardiology, Tabba Heart Institute, Karachi, PAK.

Background and objective Myocardial infarction (MI) is the leading cause of mortality and morbidity worldwide. Early diagnosis of MI remains the mainstay of prompt treatment. Thus, the shorter the door-to-needle time, the more efficient is the emergency department (ED) to cope with a heart attack emergency. Read More

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http://dx.doi.org/10.7759/cureus.8201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302873PMC

Antihypertensive effect of carvacrol is improved after incorporation in β-cyclodextrin as a drug delivery system.

Clin Exp Pharmacol Physiol 2020 Jun 22. Epub 2020 Jun 22.

Laboratory of Cardiovascular Physiology and Pharmacology, Federal University of Bahia, Salvador, Bahia, Brazil.

Carvacrol (CARV), has been shown to possess various pharmacological properties, especially in the treatment of cardiovascular diseases. We evaluated the antihypertensive effect of the CARV free and encapsulation of CARV in β-cyclodextrin (CARV/β-CD), and whether CARV/β-CD is able to improve the antihypertensive effects of CARV free in spontaneously hypertensive rats (SHR). The rats were randomly divided into 4 groups, each treated daily for 21 days and the mean arterial pressure and heart rate was measured every 5 days: group 1 (Wistar-vehicle solution); group 2 (SHR-vehicle); group 3 (SHR-CARV 50 mg/kg/day) and group 4 (CARV/β-CD 50 mg/kg/day). Read More

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http://dx.doi.org/10.1111/1440-1681.13364DOI Listing

Effects of acupuncture on cardiovascular risks in patients with hypertension: a Korean cohort study.

Acupunct Med 2020 Jun 20:964528420920290. Epub 2020 Jun 20.

Research Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University and WHO Collaborating Center for Traditional Medicine, Seoul, South Korea.

Objectives: The aim of this study was to investigate the effects of acupuncture on major adverse cardiovascular events (MACE), myocardial infarction, stroke and death in hypertensive patients taking anti-hypertensives.

Methods: Using the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) database, this study identified 59,370 patients taking anti-hypertensives who had been diagnosed with hypertension between 2003 and 2006. They were divided into acupuncture and non-acupuncture groups. Read More

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http://dx.doi.org/10.1177/0964528420920290DOI Listing

A new definition of gestational hypertension? New onset blood pressures of 130-139/80-89 mmHg after 20 weeks of gestation.

Am J Obstet Gynecol 2020 Jun 15. Epub 2020 Jun 15.

Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO.

Background: Diagnostic criteria for hypertensive disorders of pregnancy have historically been based on the American Heart Association/American College of Cardiology's definition of hypertension, previously defined as a blood pressure ≥140/90 mmHg. With the recent redefinition of hypertension, blood pressures of 130-139/80-89 mmHg are now considered abnormal.

Objective: We aimed to test whether new-onset blood pressure elevations of 130-139/80-89 mmHg after 20 weeks of gestation in previously normotensive women are associated with increased risk of adverse pregnancy outcomes, specifically development of hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.019DOI Listing

Safety and Efficacy of Ahmed Valve on Intractable Glaucoma in Saudi Population.

Middle East Afr J Ophthalmol 2020 Jan-Mar;27(1):40-46. Epub 2020 Apr 29.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: The study aims to assess the efficacy and safety of Ahmed glaucoma valve implant in eyes with intractable glaucoma and to evaluate the risk factors for failure.

Methods: A retrospective evaluation of 83 patients (117 eyes) with intractable glaucoma who underwent silicone Ahmed glaucoma valve implant was done in a tertiary care center in Riyadh, Saudi Arabia, between January 2014 and December 2016. Complete success was defined as intraocular pressure (IOP) ≤21 mmHg without medication after a minimum follow-up of 6 months. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_249_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276174PMC

Management of adults with coarctation of aorta.

World J Cardiol 2020 May;12(5):167-191

Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ 85259, United States.

Coarctation of the aorta (CoA) is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose. The hallmark finding on physical examination is upper extremity hypertension, and for this reason, CoA should be considered in any young hypertensive patient, justifying measurement of lower extremity blood pressure at least once in these individuals. The presence of a significant pressure gradient between the arms and legs is highly suggestive of the diagnosis. Read More

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http://dx.doi.org/10.4330/wjc.v12.i5.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284000PMC

Determinants of Selected Cardiovascular Diseases among Adult Patients at Cardiac Clinic of Debre Berhan Referral Hospital, Ethiopia: Unmatched Case-Control Study.

Cardiovasc Ther 2020 19;2020:7036151. Epub 2020 May 19.

Department of English, College of Social Sciences, Debre Berhan University, Debre Berhan, Ethiopia.

Background: Africans are experiencing a rapid epidemiological transition characterized by urbanization and lifestyle changes, which are thought to contribute to increased incidence and prevalence of cardiovascular diseases (CVDs) in many African countries, including Ethiopia. Despite this, however, there is scarcity of evidence on cardiovascular disease risk factors among adults in the current research setting. This study thus aimed at assessing determinants of selected cardiovascular diseases among adult patients at Debre Berhan Referral Hospital (DBRH). Read More

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http://dx.doi.org/10.1155/2020/7036151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273416PMC

Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.

Hypertens Res 2020 Jun 15. Epub 2020 Jun 15.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Cardiac remodeling is an important pathological process ultimately leading to heart failure. Ubiquitin carboxy-terminal hydrolase 1 (UCHL1) is a deubiquitinase that plays a critical role in neurodegenerative diseases and cancer. However, its role in cardiac remodeling in spontaneously hypertensive rats remains unclear. Read More

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http://dx.doi.org/10.1038/s41440-020-0486-1DOI Listing

Sensitive marker for evaluation of hypertensive heart disease: extracellular volume and myocardial strain.

BMC Cardiovasc Disord 2020 Jun 15;20(1):292. Epub 2020 Jun 15.

Cardiopulmonary function department, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.

Background: Evaluation of tissue fibrosis and myocardial hypertrophy in left ventricular (LV) remodeling is the basis of post-treatment evaluation of hypertensive heart disease (HHD). Extracellular volume (ECV) and myocardial strain parameters can indirectly reflect the changes of both. Our objective was to analyze the characteristics of ECV and strain parameters in LV myocardium of HHD with varying degrees of systolic dysfunction, and to explore the changes of both after treatment for hypertension. Read More

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http://dx.doi.org/10.1186/s12872-020-01553-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294608PMC

[Update on beta blockers in 2020].

Rev Med Interne 2020 Jun 9. Epub 2020 Jun 9.

Service de Cardiologie, CHRU et Université de Tours. Hôpital Trousseau, Avenue de la République - 37170 Chambray-lès-Tours, France. Electronic address:

Beta-blockers (BB) are an heterogenous set of molecules actively blocking β adrenergic receptors. Their pharmacological properties depend on their various effects on the adrenergic signalling. Although they are no longer a first-choice treatment in hypertensive patients, they remain a cornerstone of pharmacological strategy in several cardiovascular diseases such as stable angina, heart failure, arrythmia and aortic related connective diseases. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.04.007DOI Listing

Transcriptomic landscape profiling of metformin-treated healthy mice: Implication for potential hypertension risk when prophylactically used.

J Cell Mol Med 2020 Jun 11. Epub 2020 Jun 11.

Department of Physiology and Pathophysiology, Department of Biomedical Informatics, Center for Non-coding RNA Medicine, MOE Key Lab of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing, China.

Recently, the first-line anti-diabetic drug metformin shows versatile protective effects against several diseases and is potentially prescribed to healthy individual for prophylactic use against ageing or other pathophysiological processes. However, for healthy individuals, it remains unclear what effects metformin treatment will induce on their bodies. A systematic profiling of the molecular landscape of metformin treatment is expected to provide crucial implications for this issue. Read More

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http://dx.doi.org/10.1111/jcmm.15472DOI Listing

Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort.

Hypertens Res 2020 Jun 11. Epub 2020 Jun 11.

Department of Epidemiology, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, USA.

A shift towards high folate concentration has emerged following folate fortification. However, the association between folate and health outcomes beyond neural tube defects remains inconclusive. To assess the relationship between red blood cell (RBC) folate and the risk of cardiovascular death among hypertensive patients, we analyzed the data of 2,986 adults aged 19 or older with hypertension who participated in the National Health and Nutrition Examination Survey (1991-1994) as the baseline examination and were followed up through December 31, 2010. Read More

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http://dx.doi.org/10.1038/s41440-020-0482-5DOI Listing
June 2020
2.658 Impact Factor

Association of systolic blood pressure with atrial fibrillation among treated hypertensive patients.

Ann Palliat Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Hypertension Research Laboratory, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Background: Although many studies have suggested the association between elevated blood pressure and atrial fibrillation (AF), how the relationship between systolic blood pressure (SBP) and AF differ by antihypertensive treatment has been unclear. Therefore, this study aimed to explore the relationship between SBP and AF in hypertensive patients with or without antihypertensive treatment.

Methods: This was a cross-sectional study that enrolled 7,808 hypertensive patients aged ≥18 years old in 2013 in Guangdong, China. Read More

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http://dx.doi.org/10.21037/apm-19-649DOI Listing

Multiple impacts and pathways of urban form and environmental factors on cardiovascular mortality.

Sci Total Environ 2020 May 19;738:139512. Epub 2020 May 19.

Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan; Department of Atmospheric Sciences, National Taiwan University, Taipei, Taiwan; Institute of Environmental Health, National Taiwan University, Taipei, Taiwan. Electronic address:

Air pollution and heat are significant threats to public health, especially in urban areas with intensive human activities under the trend of climate change. However, the mediation effects of urban form on health via air pollution and heat have been overlooked in previous investigations. This study explored the potential impacts and pathways of urban form on cardiovascular mortality through air pollutants and heat by using partial least squares model with data from Taiwan. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139512DOI Listing

Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage.

Sci Rep 2020 Jun 10;10(1):9383. Epub 2020 Jun 10.

Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, 37007, Spain.

Cardiovascular diseases are associated to risk factors as obesity, hypertension and diabetes. The transforming growth factor-β1 receptors ALK1 and endoglin regulate blood pressure and vascular homeostasis. However, no studies relate the association of ALK1 and endoglin polymorphisms with cardiovascular risk factors. Read More

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http://dx.doi.org/10.1038/s41598-020-66238-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287057PMC

Pregnancy and cardiovascular disease.

Nat Rev Cardiol 2020 Jun 9. Epub 2020 Jun 9.

Department of Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands.

Cardiovascular disease complicates 1-4% of pregnancies - with a higher prevalence when including hypertensive disorders - and is the leading cause of maternal death. In women with known cardiovascular pathology, such as congenital heart disease, timely counselling is possible and the outcome is fairly good. By contrast, maternal mortality is high in women with acquired heart disease that presents during pregnancy (such as acute coronary syndrome or aortic dissection). Read More

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http://dx.doi.org/10.1038/s41569-020-0390-zDOI Listing

Latency of preterm hypertensive disorders of pregnancy and subsequent cardiovascular complications.

Pregnancy Hypertens 2020 May 31;21:139-144. Epub 2020 May 31.

Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, USA.

Objectives: To test the hypothesis that increasing latency from diagnosis to delivery in patients with preterm hypertensive disorders of pregnancy is associated with an increased maternal risk of cardiovascular admission after delivery.

Study Design: Retrospective cohort from the IBM MarketScan® Commercial Database from 2006 to 2016. Patients age 15-45 years with a preterm delivery complicated by a hypertensive disorder of pregnancy, at least 6 months of continuous insurance coverage prior to delivery and at least 365 days of coverage post-delivery were included. Read More

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http://dx.doi.org/10.1016/j.preghy.2020.05.015DOI Listing

Maternal myocardial dysfunction after normotensive fetal growth restriction compared with hypertensive pregnancies: a speckle-tracking study.

J Hypertens 2020 Jun 6. Epub 2020 Jun 6.

Department of Obstetrics and Gynecology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC), The Netherlands.

Objective: Pregnancy complicated by preeclampsia and fetal growth restriction (FGR) relates to increased risk of cardiovascular disease later in life, but to different extents. Subclinical cardiac alterations precede eminent cardiovascular disease. Speckle-tracking echocardiography is an elegant method to assess subclinical myocardial dysfunction. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002496DOI Listing

Mid-Aortic Syndrome: A Rare Cause of Renovascular Hypertension in Childhood Treated Percutaneously with an Unusual Vascular Access.

Curr Pediatr Rev 2020 06 9. Epub 2020 Jun 9.

Azienda Ospedaliero Universitaria Policlinico, Pediatric Hospital Giovanni XXIII, Pediatric Nephrology and dialysis Unit, Bari. Italy.

Introduction: Mid-Aortic Syndrome (MAS) is a rare vascular malformation characterized by segmental narrowing of the abdominal aorta and stenosis of its principal branches. Patients affected by MAS typically present malignant renovascular hypertension, with variable clinical symptoms like claudication, abdominal angina and headache. Moreover, they can develop complications such as hypertensive encephalopathy, congestive heart failure and vascular brain accidents. Read More

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http://dx.doi.org/10.2174/1573396316666200609170003DOI Listing

Maternal Predictors of Disparate Outcomes in Children With Single Ventricle Congenital Heart Disease.

J Am Heart Assoc 2020 Jun 9;9(12):e014363. Epub 2020 Jun 9.

Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT.

Background Significant variability in morbidity and mortality persists for children with functionally single ventricle congenital heart disease (SV-CHD) despite standardization in medical and surgical care. We hypothesized that maternal health factors may be associated with an increased risk of poor outcomes in children with SV-CHD. Methods and Results This retrospective, observational, cohort study included term maternal-infant pairs with a diagnosis of SV-CHD who underwent surgical palliation from 2006 to 2015 at Primary Children's Hospital. Read More

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http://dx.doi.org/10.1161/JAHA.119.014363DOI Listing

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats.

Elife 2020 Jun 8;9. Epub 2020 Jun 8.

Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and protects cardiac LDH exposed to HPS produced by the contracting heart. Read More

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http://dx.doi.org/10.7554/eLife.57028DOI Listing

Heart Failure with Preserved Ejection Fraction in a Postpartum Patient with Superimposed Preeclampsia and COVID-19.

AJP Rep 2020 Apr 4;10(2):e165-e168. Epub 2020 Jun 4.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.

Our understanding of COVID-19 in pregnant and postpartum women is rapidly evolving. We present a case from March 2020 of a 25-year-old G2P2002 whose delivery was complicated by preeclampsia with severe features who presented to the emergency department 9 days after cesarean delivery with chest tightness and dyspnea on exertion. On presentation she had severe hypertension, pulmonary edema, elevated brain natriuretic peptide, and high-sensitivity troponin-I, suggesting a diagnosis of hypertensive emergency leading to heart failure with a preserved ejection fraction resulting in pulmonary edema and abnormal cardiac screening tests. Read More

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http://dx.doi.org/10.1055/s-0040-1712926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272215PMC

Hemodynamic Characterization of Primary Hypertension in Children and Adolescents.

J Am Heart Assoc 2020 Jun 6;9(12):e015097. Epub 2020 Jun 6.

King's College London British Heart Foundation Centre London United Kingdom.

Background Primary hypertension in children is often characterized by high pulse pressure that could be attributable to increased ventricular ejection velocities and volumes and/or increased arterial stiffness. The objective of this study was to examine the contributions of cardiac (ventricular ejection) and vascular (systemic vascular resistance, arterial stiffness, and pressure wave reflection) properties to primary hypertension in children and adolescents. Methods and Results Children aged 8 to 18 years referred to a tertiary center for evaluation of hypertension and found to have primary hypertension (n=31) were compared with normotensive controls of similar age (n=50). Read More

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http://dx.doi.org/10.1161/JAHA.119.015097DOI Listing

1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats.

Am J Physiol Renal Physiol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, United States.

Thirty-seven million people in the United States are estimated to have chronic kidney disease (CKD). Hypertension (HTN) is the second leading risk factor for developing kidney disease. A recent study reported that increasing levels of β-hydroxybutyrate levels by administration of its precursor 1,3-Butanediol decreased salt-induced HTN in male Dahl salt-sensitive (S) rats. Read More

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http://dx.doi.org/10.1152/ajprenal.00141.2020DOI Listing

Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.

Hypertension 2020 Jun 8:HYPERTENSIONAHA12014972. Epub 2020 Jun 8.

From the Department of Physiology, Medical College of Wisconsin, Milwaukee (P.N., J.G., J.W., K.-T.L., J.L.G., C.D.S.).

Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The classical renin isoform (renin-a) encoding preprorenin is mainly confined to the juxtaglomerular cells and released into the circulation upon stimulation. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14972DOI Listing
June 2020
6.480 Impact Factor

Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial.

Am Heart J 2020 May 13;226:49-59. Epub 2020 May 13.

D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil; Rede D'Or São Luiz (RDSL), São Paulo, Brazil.

Angiotensin-converting enzyme-2 (ACE2) expression may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). Because renin-angiotensin system blockers increase levels of ACE2, a protein that facilitates coronavirus entry into cells, there is concern that these drugs could increase the risk of developing a severe and fatal form of COVID-19. The impact of discontinuing ACEI and ARBs in patients with COVID-19 remains uncertain. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219415PMC

Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case-control study.

BMJ Open 2020 Jun 3;10(6):e034145. Epub 2020 Jun 3.

Cardiology, University of California San Francisco, San Francisco, California, USA

Objective: To determine whether maternal cardiovascular disease (CVD) risk factors predict preterm birth.

Design: Case control.

Setting: California hospitals. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282308PMC

Acute total body ionizing gamma radiation induces long-term adverse effects and immediate changes in cardiac protein oxidative carbonylation in the rat.

PLoS One 2020 4;15(6):e0233967. Epub 2020 Jun 4.

Center for Drug Evaluation and Research, Office of Biotechnology Products, United States Food and Drug Administration, Silver Spring, Maryland, United States of America.

Radiation-induced heart disease presents a significant challenge in the event of an accidental radiation exposure as well as to cancer patients who receive acute doses of irradiation as part of radiation therapy. We utilized the spontaneously hypertensive Wistar-Kyoto rat model, previously shown to demonstrate drug-induced cardiomyopathy, to evaluate the acute and long-term effects of sub-lethal total body gamma irradiation at two, four, and fifty-two weeks. We further examined irreversible oxidative protein carbonylation in the heart immediately following irradiation in the normotensive Wistar-Kyoto rat. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233967PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272027PMC

Baseline characteristics predicting clinical outcomes and serious adverse events in middle-aged hypertensive women: a sub-analysis of the SPRINT in women aged <65 years.

Turk J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Background/aim: The predictability of clinical outcomes in hypertension in specific patient groups, especially underrepresented populations is the key to rational treatment. This study aimed to investigate the impact of baseline characteristics of <65-year-old hypertensive women with an increased risk of cardiovascular events, managed with standard- or intensive-approach, on their clinical outcomes and serious adverse events (SAEs).

Materials And Methods: Baseline characteristics of <65-year-old hypertensive women (n=1247) in SPRINT, a multicenter randomized trial to compare standard and intensive antihypertensive treatment, were analyzed with Cox-regression method to determine potential predictors of the clinical outcomes and SAEs. Read More

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http://dx.doi.org/10.3906/sag-1907-144DOI Listing

[A study of alexithymia in schizophrenia and some somatic diseases].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(4):36-40

Azerbaijan Medical University Baku, Azerbaijan Republi, Azerbaijan Medical University Baku, Azerbaijan Republic.

Objective: To study alexithymia in schizophrenia and some somatic diseases.

Material And Methods: The study included 60 patients with paranoid schizophrenia (ICD-10 F20.0), 55 hypertensive patients with primary heart disease (I11), 53 patients with chronic ischemic heart disease (I25) and 51 patients with insulin-dependent diabetes mellitus (E10). Read More

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http://dx.doi.org/10.17116/jnevro202012004136DOI Listing
January 2020

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective.

Glob Heart 2020 Feb 12;15(1):15. Epub 2020 Feb 12.

Department of Medicine, Harvard Medical School, Boston, US.

Non-communicable diseases (NCDs) are the second common cause of death in sub-Saharan Africa (SSA) accounting for about 35% of all deaths, after a composite of communicable, maternal, neonatal, and nutritional diseases. Despite prior perception of low NCDs mortality rates, current evidence suggests that SSA is now at the dawn of the epidemiological transition with contemporary double burden of disease from NCDs and communicable diseases. In SSA, cardiovascular diseases (CVDs) are the most frequent causes of NCDs deaths, responsible for approximately 13% of all deaths and 37% of all NCDs deaths. Read More

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http://dx.doi.org/10.5334/gh.403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218780PMC
February 2020

Mind the gaps: age and cause specific mortality and life expectancy in the older population of South Korea and Japan.

BMC Public Health 2020 Jun 1;20(1):819. Epub 2020 Jun 1.

Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, South Korea.

Background: Recent life expectancy gains in high-income Asia-pacific countries have been largely the result of postponement of death from non-communicable diseases in old age, causing rapid demographic ageing. This study compared and quantified age- and cause-specific contributions to changes in old-age life expectancy in two high-income Asia-pacific countries with ageing populations, South Korea and Japan.

Methods: This study used Pollard's actuarial method of decomposing life expectancy to compare age- and cause-specific contributions to changes in old-age life expectancy between South Korea and Japan during 1997 and 2017. Read More

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http://dx.doi.org/10.1186/s12889-020-08978-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268756PMC

Baseline Serum Bilirubin and Risk of First Stroke in Hypertensive Patients.

J Am Heart Assoc 2020 Jun 3;9(12):e015799. Epub 2020 Jun 3.

National Clinical Research Center for Kidney Disease the State Key Laboratory for Organ Failure Research Renal Division Nanfang Hospital Southern Medical University Guangzhou China.

Background Data on the association between serum bilirubin and the risk of stroke are limited and inconclusive. We aimed to evaluate the association between serum bilirubin and the risk of first stroke and to examine any possible effect modifiers in hypertensive patients. Methods and Results Our study was a post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial). Read More

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http://dx.doi.org/10.1161/JAHA.119.015799DOI Listing

Anti-Anaphylactic Activity of Isoquercitrin (Quercetin-3-O-β-d-Glucose) in the Cardiovascular System of Animals.

Authors:
Jinbong Park

Biomedicines 2020 May 29;8(6). Epub 2020 May 29.

Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Effects of isoquercitrin (IQ) on anaphylactic responses were examined in cardiovascular systems of experimental animals. In pithed rats, IQ at 30 and 100 mg/kg (intravenous) significantly blunted both the initial hypertensive and the ensuing hypotensive responses during anaphylaxis. Death rate and tachycardia were also significantly inhibited after the same IQ doses in these rats. Read More

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http://dx.doi.org/10.3390/biomedicines8060139DOI Listing