823 results match your criteria Hypertension in Pregnancy [Journal]


Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.

Hypertens Pregnancy 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil.

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.

Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.

Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. Read More

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http://dx.doi.org/10.1080/10641955.2019.1577435DOI Listing
February 2019

T lymphocytes in the third trimester decidua in preeclampsia.

Hypertens Pregnancy 2019 Feb 11:1-6. Epub 2019 Feb 11.

c Department of Pathology, Faculty of Medicine , University of Nis , Nis , Serbia.

Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia.

Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. Read More

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http://dx.doi.org/10.1080/10641955.2019.1575393DOI Listing
February 2019
1 Read

New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia.

Hypertens Pregnancy 2019 Feb 1:1-11. Epub 2019 Feb 1.

c Fertility and Infertility Research Center , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.

Objective: Dysregulation of lncRNAs and the absence of coordination between them could affect the normal placentation, uteroplacental circulation, and endothelial cell function. All these misfunctions can finally lead to preeclampsia.

Methods:  In the present review, we discuss current literature (till May 2018) about lncRNAs expression and function in the placenta, trophoblast cells, and decidua. Read More

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http://dx.doi.org/10.1080/10641955.2019.1573252DOI Listing
February 2019
1 Read

A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia.

Hypertens Pregnancy 2019 Jan 3:1-12. Epub 2019 Jan 3.

a Department of Obstetrics , Chongqing Health Center for Women and Children , Chongqing , P.R. China.

Previous observations investigated the association of tumor necrosis factor-α (TNF-α), FAS and FASL polymorphisms with the risk of pre-eclampsia (PE). Conflicting results, however, were obtained. In this study, we aimed to evaluate the association between TNF-α -308 A/G, -850 C/T, -238 A/G, FAS -670 A/G, and FASL -844 C/T and PE risk using a meta-analysis. Read More

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http://dx.doi.org/10.1080/10641955.2018.1543432DOI Listing
January 2019
1 Read

Correlation between uterine artery Doppler and the sFlt-1/PlGF ratio in different phenotypes of placental dysfunction.

Hypertens Pregnancy 2018 Nov 28:1-9. Epub 2018 Nov 28.

a Department of Perinatology, Division of Obstetrics and Gynecology , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Objective: To explore correlations between the sFlt-1/PlGF ratio and uterine arteries (UtA) Doppler indexes in placental dysfunction-related disorders (PDD).

Methods: We prospectively included women with a singleton pregnancy with preeclampsia (PE) only (n = 22), preeclampsia with fetal growth restriction (FGR) (n = 32), FGR only (n = 12), or normal pregnancy (n = 29).

Results: In PDDs, significantly positive correlations between the sFlt-1/PlGF ratio and the mean UtA pulsatility (mPI-UtA), as well as the resistance index (mRI-UtA) were found (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1550579DOI Listing
November 2018
2 Reads

Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease.

Hypertens Pregnancy 2018 Nov 2:1-7. Epub 2018 Nov 2.

c Department of Obstetrics and Gynecology , Health Sciences University, Zeynep Kamil Maternity and Children's Training and Research Hospital , İstanbul , Turkey.

Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies.

Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women.

Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1540702DOI Listing
November 2018
3 Reads

Investigation of elevation as a risk factor for hypertensive disorders of pregnancy among Colorado women between 2007 and 2015.

Hypertens Pregnancy 2018 Nov 1:1-12. Epub 2018 Nov 1.

b Department of Epidemiology , Colorado School of Public Health , Aurora , Colorado , USA.

Objective: The purpose of this study is to determine the association between high elevation and hypertensive disorders of pregnancy (HDP).

Methods: Retrospective cohort study using Colorado birth certificate data to compare HDP at high (≥8,000 ft), moderate (4,501-7,999 ft), or low (≤4,500 ft) elevation using logistic regression.

Results: Among the cohort (n = 314,431), 3. Read More

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http://dx.doi.org/10.1080/10641955.2018.1538378DOI Listing
November 2018
1 Read

Serum neopterin levels in women with preeclampsia: a systematic review.

Hypertens Pregnancy 2018 Nov 9;37(4):220-226. Epub 2018 Oct 9.

c 1st dpt of Obstetrics and Gynecology , Alexandra University Hospital, National and Kapodistrian University of Athens , Athens , Greece.

Objective: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Several studies suggest its association with preeclampsia and the purpose of the present study is to evaluate this assumption.

Methods: We searched the Medline (1992-2018), Scopus (1993-2018) and Google Scholar (1993-2018) databases. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1526300DOI Listing
November 2018
2 Reads

Maternal levels of growth differentiation factor-15 in patients with preeclampsia.

Hypertens Pregnancy 2018 Nov 6;37(4):192-196. Epub 2018 Oct 6.

a Department of Obstetrics and Gynecology , Kanuni Sultan Suleyman Research and Training Hospital , Istanbul , Turkey.

Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE).

Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524477DOI Listing
November 2018
4 Reads

Peripheral arterial tonometry and angiogenic biomarkers in preeclampsia.

Hypertens Pregnancy 2018 Nov 4;37(4):197-203. Epub 2018 Oct 4.

a Institute of Clinical Chemistry and Biochemistry , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Objective: To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future.

Methods: Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay.

Results: Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524478DOI Listing
November 2018
1 Read

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy.

Hypertens Pregnancy 2018 Nov 2;37(4):175-181. Epub 2018 Oct 2.

a Department Obstetrics & Gynecology, DR. Soetomo - UNAIR Hospital , Universitas Airlangga , Surabaya , Indonesia.

Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP).

Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). Read More

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http://dx.doi.org/10.1080/10641955.2018.1494187DOI Listing
November 2018
13 Reads

Serial profile of flow-mediated dilatation in primigravida for prediction of preeclampsia and gestational hypertension.

Hypertens Pregnancy 2018 Nov 1;37(4):212-219. Epub 2018 Oct 1.

a Department of Physiology , Government Medical College and Hospital , Chandigarh , India.

Objective: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE).

Methods: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524480DOI Listing
November 2018
7 Reads
1.192 Impact Factor

Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output.

Hypertens Pregnancy 2018 Nov 26;37(4):204-211. Epub 2018 Sep 26.

a Department of Epidemiology, Graduate School of Public Health , University of Pittsburgh , Pittsburgh , PA , USA.

Objective: To assess brachial artery distensibility and associated factors in healthy primigravidas.

Methods: We assessed brachial artery distensibility using the DynaPulse 5,000A in 37 women each trimester, and 6-8 weeks and 1-5 years postpartum. Associations with physical and cardiometabolic measures were considered. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330891PMC
November 2018
15 Reads

Arterial stiffness during controlled ovarian hyperstimulation and early pregnancy in women exposed to assisted reproduction.

Hypertens Pregnancy 2018 Nov 21;37(4):182-191. Epub 2018 Sep 21.

c Cura Mödravård, Institution of Clinical Sciences Malmö , Lund University , Malmö , Sweden.

Introduction: Female sex hormones have vasorelaxing effects in non-pregnant and pregnant women. We aimed to investigate the effect of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), and early pregnancy, on arterial stiffness as assessed by digital pulse wave analysis (DPA), hypothesizing reduced arterial stiffness as an effect of increased estrogen levels.

Material And Methods: A total of 68 women undergoing IVF were examined with DPA before conception and during IVF treatment with COH and embryo transfer (ET), and in gestational week seven in 19 women who became pregnant. Read More

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http://dx.doi.org/10.1080/10641955.2018.1516225DOI Listing
November 2018
1 Read

The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes.

Hypertens Pregnancy 2018 Aug 24;37(3):118-125. Epub 2018 Jul 24.

k Department of Obstetrics and Gynecology , The Second Hospital of Hebei Medical University , Shijiazhuang , China.

Background: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population.

Study Design: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria < 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1487564DOI Listing
August 2018
2 Reads

Association between hypertensive disorders complicating pregnancy and risk of placenta accreta: a meta-analysis and systematic review.

Hypertens Pregnancy 2018 Aug 24;37(3):168-174. Epub 2018 Jul 24.

a Department of Obstetrics , Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan , Foshan , Guangdong , China.

Objective: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498880DOI Listing
August 2018
11 Reads
1.192 Impact Factor

Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study.

Hypertens Pregnancy 2018 Aug 22;37(3):137-143. Epub 2018 Jul 22.

b Department of Medical Biochemistry, Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications.

Methods: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Read More

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http://dx.doi.org/10.1080/10641955.2018.1494188DOI Listing
August 2018
17 Reads
1.192 Impact Factor

Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.

Hypertens Pregnancy 2018 Aug 19;37(3):154-159. Epub 2018 Jul 19.

b Sleep Disorders Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Objective: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia.

Methods: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498879DOI Listing
August 2018
15 Reads

Urinary clusterin and glutathione-s-transferase levels in HIV positive normotensive and preeclamptic pregnancies.

Hypertens Pregnancy 2018 Aug 19;37(3):160-167. Epub 2018 Jul 19.

a Optics and Imaging Centre, Doris Duke Medical Research Institute, College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.

Objective: To determine the level and effect of urinary clusterin (CLU) and glutathione-s-transferase (GST) proteins in normotensive and preeclamptic pregnant women with HIV infection.

Methods: The urine concentration of CLU and GST in normotensive (n = 38) and preeclamptic pregnant (n = 38) women stratified by HIV status were estimated using the Bio-Plex® Pro immunoassay.

Results: Across the group, a significant down-regulation of CLU (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498881DOI Listing
August 2018
2 Reads

Serum magnesium level in the first trimester of pregnancy as a predictor of pre-eclampsia - a pilot study.

Hypertens Pregnancy 2018 Aug 18;37(3):144-153. Epub 2018 Jul 18.

a Faculty of Medicine, Department of Pathophysiology and Laboratory Medicine , University of Novi Sad , Novi Sad , Serbia.

Objectives: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE).

Methods: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 342). Read More

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http://dx.doi.org/10.1080/10641955.2018.1494189DOI Listing
August 2018
4 Reads

Uterine artery flow velocity waveforms before and after delivery in hypertensive disorders of pregnancy near term.

Hypertens Pregnancy 2018 Aug 18;37(3):131-136. Epub 2018 Jul 18.

a Department of Obstetrics and Gynecology , University of Tennessee Health Science Center , Memphis , TN , USA.

Objective: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term.

Methods: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Read More

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http://dx.doi.org/10.1080/10641955.2018.1493495DOI Listing
August 2018
5 Reads

The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension.

Hypertens Pregnancy 2018 Aug 17;37(3):126-130. Epub 2018 Jul 17.

a Division of Maternal Fetal Medicine , The University of Texas Medical Branch , Galveston , TX , USA.

Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Read More

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http://dx.doi.org/10.1080/10641955.2018.1493494DOI Listing
August 2018
2 Reads

First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk.

Hypertens Pregnancy 2018 Aug 12;37(3):111-117. Epub 2018 Jun 12.

d Department of Pediatrics, Faculty of Medicine , Menoufia University , Shibin El-Kom City , Egypt.

Objective: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk.

Methods: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236). Test validity of MPV and serum uric acid was the primary outcome measure. Read More

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http://dx.doi.org/10.1080/10641955.2018.1483508DOI Listing
August 2018
12 Reads

Morphological and structural changes of umbilical veins and clinical significance in preeclampsia.

Hypertens Pregnancy 2018 Aug 7;37(3):105-110. Epub 2018 May 7.

a Morphological Laboratory , Hainan Medical University , Haikou , China.

Objective: Preeclampsia is a common complication of pregnancy that is characterized by high blood pressure. Preeclampsia can have both negative maternal and fetal effects, including impaired fetal development from reduced placental perfusion. Because umbilical vessels provide fetal blood supply, morphological changes in these vessels can critically affect fetal function. Read More

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http://dx.doi.org/10.1080/10641955.2017.1420799DOI Listing
August 2018
3 Reads

Association between serum CA125 levels in preeclampsia and its severity among women in Lagos, South-West Nigeria.

Hypertens Pregnancy 2018 May 2;37(2):93-97. Epub 2018 May 2.

b Obstetrics & Gynaecology , College of Medicine University of Lagos , Lagos , Nigeria.

Background: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460667DOI Listing
May 2018
11 Reads
1.192 Impact Factor

Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk.

Hypertens Pregnancy 2018 May 1;37(2):87-92. Epub 2018 May 1.

a Department of Epidemiology and Biostatistics, School of Public Health , Tongji Medical College of Huazhong University of Science & Technology , Wuhan , China.

Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women.

Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460666DOI Listing
May 2018
6 Reads

Cardiovascular risk after preeclampsia: The effect of communicating risk factors on intended healthy behavior.

Hypertens Pregnancy 2018 May 25;37(2):98-103. Epub 2018 Apr 25.

a Department of Obstetrics & Gynecology , VU University Medical Center , Amsterdam , The Netherlands.

Objective: We studied the effect of communicating cardiovascular risk factors on intended healthy behavior in women with a history of preeclampsia or uncomplicated pregnancy.

Methods: Intention for healthy behavior was assessed before and after cardiovascular risk assessment. Changes were calculated for women with and without cardiovascular risk factors. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460668DOI Listing
May 2018
4 Reads

Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.

Hypertens Pregnancy 2018 May 16;37(2):68-80. Epub 2018 Apr 16.

a Research center , Centre hospitalier universitaire de Québec , Québec , Canada.

Objectives: The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia.

Methods: 131 pregnant women considered at risk of preeclampsia based on uterine artery Doppler ultrasound were divided into two groups (HFHT or low flavanol and theobromine chocolate (LFLT). Acute changes in plasma flavanol and theobromine, peripheral arterial tonometry and BP were evaluated at randomization (0, 60 and 120 min after a single 40-g dose of chocolate) and again 6 and 12 weeks after daily 30-g chocolate intake. Read More

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http://dx.doi.org/10.1080/10641955.2018.1446977DOI Listing
May 2018
11 Reads

Relation of locus 1p13 rs646776 polymorphism with the risk of preeclampsia.

Hypertens Pregnancy 2018 May 25;37(2):81-86. Epub 2018 Mar 25.

a Faculty of Pharmacy, Department of Biochmistry , Suez Canal University , Ismailia , Egypt.

Objective: This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women.

Methods: The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Read More

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http://dx.doi.org/10.1080/10641955.2018.1454462DOI Listing
May 2018
4 Reads

Safety of a physical therapy protocol for women with preeclampsia: a randomized controlled feasibility trial.

Hypertens Pregnancy 2018 May 1;37(2):59-67. Epub 2018 Mar 1.

c Department of Gynecology and Obstretrics, Ribeirão Preto Medical School , University of São Paulo , Ribeirão Preto , Brazil.

Objective: To assess the feasibility and safety of a physiotherapy protocol applied to pregnant women with preeclampsia.

Methods: Randomized, controlled, single-blind feasibility study, with 24 hospitalized pregnant women with preeclampsia. The intervention group received one session of the physiotherapy. Read More

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http://dx.doi.org/10.1080/10641955.2018.1439059DOI Listing
May 2018
4 Reads

Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia.

Hypertens Pregnancy 2018 Feb 8;37(1):37-50. Epub 2018 Jan 8.

a Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas , Zacatecas , Mexico.

Background: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia.

Objective: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. Read More

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http://dx.doi.org/10.1080/10641955.2017.1411946DOI Listing
February 2018
16 Reads

Associations of hypertensive disorders of pregnancy and outcomes of labor induction with prostaglandin vaginal inserts.

Hypertens Pregnancy 2018 Feb 1;37(1):51-57. Epub 2018 Jan 1.

a Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology , University of California Irvine Medical Center , Orange , CA , USA.

Objective: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI).

Study Design: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery. Read More

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http://dx.doi.org/10.1080/10641955.2017.1420800DOI Listing
February 2018
7 Reads

The effect of magnesium sulfate on gene expression in maternal microvascular endothelial cells.

Hypertens Pregnancy 2018 Feb 27;37(1):30-36. Epub 2017 Nov 27.

a Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre , University of Toronto , Toronto , Ontario , Canada.

Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Read More

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http://dx.doi.org/10.1080/10641955.2017.1402924DOI Listing
February 2018
4 Reads

Relation with postpartum maternal morbidity of different types of anesthesia in preeclamptic patients.

Hypertens Pregnancy 2018 Feb 20;37(1):25-29. Epub 2017 Nov 20.

a Department of Obstetrics and Gynecology, Faculty of Medicine , Ondokuz Mayis University , Samsun , Turkey.

Objective: The aim of this study is to investigate the effect of different anesthesia types administered to patients with preeclampsia on postoperative maternal morbidities.

Methods: Medical records of pregnant women complicated with preeclampsia delivered by cesarean from January 2010 to December 2016 in our clinic were retrospectively reviewed.

Results: There was not a statistically significant difference between patients receiving spinal anesthesia and general anesthesia in terms of additional parenteral analgesic requirement at postoperative period (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2017.1402923DOI Listing
February 2018
6 Reads

Alteration in methylation level at differential methylated regions of MEST and DLK1 in fetus of preeclampsia.

Hypertens Pregnancy 2018 Feb 20;37(1):1-8. Epub 2017 Nov 20.

a Women's Hospital, School of Medicine , Zhejiang University.

Objectives: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia.

Methods: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397689DOI Listing
February 2018
7 Reads

Preeclampsia knowledge among women in Utah.

Hypertens Pregnancy 2018 Feb 15;37(1):18-24. Epub 2017 Nov 15.

a Health Science , Brigham Young University , Provo , USA.

Background: Despite the benefits of preeclampsia (PE) education in improving health outcomes, little is known about how often healthcare providers in Utah include PE in prenatal education or how much information women retain. As such, the purpose of this study was to explore PE awareness among mothers in Utah and inquire how often PE is included in prenatal education. Factors associated with PE knowledge were also investigated. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397691DOI Listing
February 2018
3 Reads

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

Hypertens Pregnancy 2018 Feb 14;37(1):9-17. Epub 2017 Nov 14.

c Ankara Universitesi, Obstetrics and Gynecology , Ankara , Turkey.

The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397690DOI Listing
February 2018
5 Reads

Editorial Board Page EOV.

Authors:

Hypertens Pregnancy 2017 11;36(4):336

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http://dx.doi.org/10.1080/10641955.2017.1271273DOI Listing
November 2017
3 Reads

Type of obstetric anesthesia administered and complications in women with preeclampsia in low- and middle-income countries: A systematic review.

Hypertens Pregnancy 2017 Nov 10;36(4):326-336. Epub 2017 Nov 10.

a Women's Health Research Unit, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London , UK.

Background: Delivery is often expedited with cesarean section, necessitating anesthesia, to prevent complications in women with preeclampsia. Anesthesia-associated risks in these women from low- and middle-income countries (LMICs) are not known.

Methods: We searched major databases (until February 2017) for studies on general vs. Read More

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http://dx.doi.org/10.1080/10641955.2017.1389951DOI Listing
November 2017
9 Reads

Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia.

Hypertens Pregnancy 2017 Nov 8;36(4):295-301. Epub 2017 Nov 8.

b Discipline of Obstetrics and Gynecology and Women's Health and HIV Research Group , Nelson R Mandela School of Medicine, University of KwaZulu-Natal , Durban , South Africa.

Objective: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia.

Methods: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay. Read More

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http://dx.doi.org/10.1080/10641955.2017.1385794DOI Listing
November 2017
5 Reads

Maternal serum autotaxin levels in early- and late-onset preeclampsia.

Hypertens Pregnancy 2017 Nov 23;36(4):310-314. Epub 2017 Oct 23.

a Department of Obstetrics and Gynecology , Istanbul University Cerrahpasa Medical Faculty , Istanbul , Turkey.

Purpose: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital.

Methods: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Read More

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http://dx.doi.org/10.1080/10641955.2017.1388389DOI Listing
November 2017
31 Reads
1.192 Impact Factor

Association between the soluble epoxide hydrolase gene and preeclampsia.

Hypertens Pregnancy 2017 Nov 23;36(4):315-325. Epub 2017 Oct 23.

d Department of Gynecology and Obstetrics , School of Medicine, Cumhuriyet University , Sivas , Turkey.

Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.

Methods: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively.

Results: The presence of the K55R polymorphism was significantly higher in cases (28. Read More

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http://dx.doi.org/10.1080/10641955.2017.1388390DOI Listing
November 2017
4 Reads

FN1, FOS, and ITGA5 induce preeclampsia: Abnormal expression and methylation.

Hypertens Pregnancy 2017 Nov 17;36(4):302-309. Epub 2017 Oct 17.

a Department of Gynecology and obstetrics , Jiyang Public Hospital, Jinan , Shandong China.

Objective: As a frequent hypertensive disorder in pregnancy, preeclampsia causes 15% of all preterm deliveries. This study aims to understand its mechanism via analyzing gene expression and methylation data.

Methods: Human gene expression microarray data (GSE73374) and corresponding DNA methylation microarray data (GSE73375) of preeclamptic placental tissues (n = 19) and normotensive placental tissues (n = 17) were obtained from the Gene Expression Omnibus. Read More

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http://dx.doi.org/10.1080/10641955.2017.1385795DOI Listing
November 2017
8 Reads

Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc.

Hypertens Pregnancy 2017 Nov 17;36(4):283-287. Epub 2017 Oct 17.

b Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia.

Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.

Methods: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014.

Results: Thirty-nine subjects were included. Read More

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http://dx.doi.org/10.1080/10641955.2017.1385792DOI Listing
November 2017
8 Reads

Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia.

Hypertens Pregnancy 2017 Nov 17;36(4):288-294. Epub 2017 Oct 17.

a Optics and Imaging Centre, Nelson R. Mandela School of Medicine, College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.

Objective: Both HIV infection and pre-eclampsia (PE) are associated with considerable maternal mortality in South Africa. This study was designed to compare the urinary levels of kidney injury molecule-1 (KIM-1), calbindin, interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in HIV associated normotensive and preeclamptic pregnancies.

Methods: Following ethical approval and written consent, urine samples were collected from HIV negative (HIV -ve) normotensive pregnant (n = 19), HIV positive (HIV +ve) normotensive pregnant (n = 19), HIV -ve pre-eclamptic (n = 19) and HIV +ve pre-eclamptic (n = 19) women. Read More

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http://dx.doi.org/10.1080/10641955.2017.1385793DOI Listing
November 2017
11 Reads

Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings.

Hypertens Pregnancy 2017 Aug 25;36(3):276-281. Epub 2017 Aug 25.

d Department of Obstetrics and Gynecology , Clinical Center , Klagenfurt , Austria.

Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations.

Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks') and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. Read More

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http://dx.doi.org/10.1080/10641955.2017.1364381DOI Listing
August 2017
11 Reads

Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction.

Hypertens Pregnancy 2017 Aug 24;36(3):269-275. Epub 2017 Jul 24.

a Department of Obstetrics and Gynecology , Yamanashi Prefectural Central Hospital , Kofu , Yamanashi , Fujimi, Japan.

Objective: To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR). Read More

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http://dx.doi.org/10.1080/10641955.2017.1334800DOI Listing
August 2017
20 Reads

The pathology of eclampsia: An autopsy series.

Hypertens Pregnancy 2017 Aug 5;36(3):259-268. Epub 2017 Jul 5.

a Department of Pathology , Beth Israel Deaconess Medical Center (BIDMC) , Boston , Massachusetts , USA.

Objective: We describe the main lesions in the liver, brain, and kidney from autopsies of women who died of eclampsia and characterize the endothelial injury.

Methods: Cases were identified from a study involving 317 maternal deaths (2003-2006) conducted at the Maputo Central Hospital (Maputo, Mozambique) in association with ISGlobal (Barcelona, Spain). Histology slides along with stains for endothelial, histiocyte, and platelet markers (CD31, CD34, CD68, CD42B) were reviewed to identify the relevant lesions. Read More

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http://dx.doi.org/10.1080/10641955.2017.1329430DOI Listing
August 2017
42 Reads

Corrigendum.

Authors:

Hypertens Pregnancy 2017 08 16;36(3):282. Epub 2017 Feb 16.

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https://www.tandfonline.com/doi/full/10.1080/10641955.2017.1
Publisher Site
http://dx.doi.org/10.1080/10641955.2017.1282278DOI Listing
August 2017
7 Reads

Role of angiopoietin-2, endoglin, and placental growth factor in HIV-associated preeclampsia.

Hypertens Pregnancy 2017 Aug 19;36(3):240-246. Epub 2017 Jun 19.

a Optics and Imaging Centre, Doris Duke Medical Research Institute , University of KwaZulu-Natal , Durban , South Africa.

Objective: The factors angiopoeitin-2 (Ang-2), endoglin (Eng), and placental growth factor (PlGF) have been implicated in the pathophysiology of preeclampsia (PE). This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women.

Methods: Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2). Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2017.1
Publisher Site
http://dx.doi.org/10.1080/10641955.2017.1326506DOI Listing
August 2017
34 Reads