835 results match your criteria Hypertension in Pregnancy [Journal]


Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.

Hypertens Pregnancy 2019 Apr 12:1-8. Epub 2019 Apr 12.

c Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Steele Center for Translational Medicine , University of Utah , Salt Lake City , USA.

Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD).

Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Read More

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http://dx.doi.org/10.1080/10641955.2019.1597107DOI Listing
April 2019
1 Read

The importance of proteinuria in preeclampsia and its predictive role in maternal and neonatal outcomes.

Hypertens Pregnancy 2019 May 2;38(2):111-118. Epub 2019 Apr 2.

a Division of Perinatology, Department of Obstetrics and Gynecology , Hacettepe University , Ankara , Turkey.

Objective: To evaluate impact of 24-h proteinuria level in preeclampsia on maternal/perinatal outcomes.

Methods: Singleton pregnancies with preeclampsia delivered after 24 weeks of gestation were included. Patients were divided into mild (0. Read More

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http://dx.doi.org/10.1080/10641955.2019.1590718DOI Listing
May 2019
1 Read

The association between calcium supplement and preeclampsia and gestational hypertension: a systematic review and meta-analysis of randomized trials.

Hypertens Pregnancy 2019 May 2;38(2):129-139. Epub 2019 Apr 2.

f Reproductive Medicine Hospital of the First Hospital of Lanzhou University , Lanzhou , China.

Objectives: The purpose of this study is to investigate whether calcium supplement with or without other drugs could reduce the risk of preeclampsia and gestational hypertension based on existed evidence, and to clarify whether there is discrepant effect among different population and using different dose.

Methods: PubMed, Cochrane library, and EMBASE database were searched. Two authors independently screened all records and extracted data. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2019.1
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http://dx.doi.org/10.1080/10641955.2019.1593445DOI Listing
May 2019
11 Reads

Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin.

Hypertens Pregnancy 2019 Mar 29:1-8. Epub 2019 Mar 29.

a Medical Physiology departement, Faculty of Medicine , Alexandria University , Alexandria , Egypt.

Background: Preeclampsia (PE) is a disorder of pregnancy associated with vitamin D (VD) deficiency. Chemerin is an adipokine significantly increased in preeclampsia and is regulated by VD.

Objectives: To determine whether VD supplementation would protect against development of PE through Chemerin reduction Methods: PE was induced in albino rats by injection of 12. Read More

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http://dx.doi.org/10.1080/10641955.2019.1597108DOI Listing

Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia.

Hypertens Pregnancy 2019 May 26;38(2):124-128. Epub 2019 Mar 26.

a Department of Cell Biology and Molecular Genetics , Sri Devaraj Urs Academy of Higher Education and Research , Kolar , India.

Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding.

Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo Red Dot assay respectively.

Results: Significant difference was observed in the levels of protein carbonyls (P = 0. Read More

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http://dx.doi.org/10.1080/10641955.2019.1590720DOI Listing
May 2019
1 Read

External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.

Hypertens Pregnancy 2019 May 20;38(2):78-88. Epub 2019 Mar 20.

a Department of Obstetrics, Division Woman and Baby , University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands.

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE).

Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Read More

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http://dx.doi.org/10.1080/10641955.2019.1584210DOI Listing
May 2019
1 Read

Incidence and outcomes of eclampsia: a single-center 30-year study.

Hypertens Pregnancy 2019 May 17;38(2):119-123. Epub 2019 Mar 17.

b Department of Obstetrics and Gynecology , Bezmialem Vakif University Medical Faculty , Istanbul , Turkey.

Objective: We aimed to determine the incidence of eclampsia at Erciyes University Hospital which is a tertiary referral center situated at central Anatolia. Additionally, we investigated eclampsia-associated maternal and perinatal outcomes for the 30-year study period.

Methods: A retrospective review was performed for all women who were diagnosed with eclampsia and admitted to the Erciyes University Medical School, Department of Obstetrics and Gynecology from January 1985 to December 2015. Read More

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http://dx.doi.org/10.1080/10641955.2019.1590719DOI Listing
May 2019
1 Read

Dysregulation of circulating sTie2 and sHER2 in HIV-infected women with preeclampsia.

Hypertens Pregnancy 2019 May 5;38(2):89-95. Epub 2019 Mar 5.

a Optics and Imaging Centre, Nelson R. Mandela School of Medicine , University of KwaZulu-Natal , Durban , South Africa.

Objective: This study assesses whether circulating sTie2 and sHER2 are altered in HIV-negative and HIV-positive pregnant normotensive and preeclamptic women.

Methods: Serum samples were obtained from 80 pregnant women, stratified into four groups, namely, HIV-negative normotensives (20); HIV-positive normotensives (20); HIV-negative preeclamptics (20); and HIV-positive preeclamptics (20). The concentration of sTie2 and sHER2 was analyzed by Bio-Plex multiplex immunoassay and generated from a standard curve. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2019.1
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http://dx.doi.org/10.1080/10641955.2019.1584211DOI Listing
May 2019
5 Reads

Circulating HO-1 levels are not associated with plasma sFLT-1 and GT HMOX1 polymorphism in preeclampsia.

Hypertens Pregnancy 2019 May 5;38(2):73-77. Epub 2019 Mar 5.

e Departments of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto , Ribeirao Preto College of Nursing, University of Sao Paulo , Ribeirao Preto , Brazil.

Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene.

Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Read More

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http://dx.doi.org/10.1080/10641955.2019.1582664DOI Listing
May 2019
4 Reads

Correlates of neutrophil/lymphocyte, platelet/lymphocyte, and platelet/neutrophil ratios of neonates of women with hypertensive disease of pregnancy with neonatal birth outcomes.

Hypertens Pregnancy 2019 May 5;38(2):105-110. Epub 2019 Mar 5.

d Department of Haematology and Immunology , University of Nigeria Teaching Hospital, Ituku-Ozalla , Enugu , Nigeria.

Background: Studies have indicated neutrophil/lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), and platelet/neutrophils ratio (PNR) to be inflammatory markers. The correlation of these values in infants of hypertensive mothers has not been investigated.

Aim: To investigate the relationship between NLR, PLR, and PNR of neonates of women with hypertensive disease of pregnancy and neonatal APGAR scores and birth weight. Read More

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http://dx.doi.org/10.1080/10641955.2019.1584819DOI Listing
May 2019
1 Read

Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia.

Hypertens Pregnancy 2019 May 1;38(2):96-104. Epub 2019 Mar 1.

a Department of Obstetrics , Affiliated Hospital of Jining Medical University , Jining , Shandong , China.

Objective: We examined whether trimethylamine-N-oxide (TMAO) plays a role in endothelial dysfunction and hypertension in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia (PE).  Methods: Normal pregnant rats and RUPP rats were treated without or with 3,3-Dimethyl-1-butanol (DMB, a TMAO inhibitor) from gestational day 14.  Results: On day 19 of gestation, RUPP rats had higher plasma TMAO, impaired vasodilation and hypertension, decreased interleukin (IL)-10, increased superoxide production and proinflammatory cytokines in the aorta. Read More

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http://dx.doi.org/10.1080/10641955.2019.1584630DOI Listing
May 2019
1 Read

The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis.

Hypertens Pregnancy 2019 May 22;38(2):65-72. Epub 2019 Feb 22.

a School of Public Health , Medical College of Soochow University , Suzhou , China.

Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia.

Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model.

Results: The pooled SMD between case and control was 1. Read More

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http://dx.doi.org/10.1080/10641955.2019.1581215DOI Listing
May 2019
1 Read
1.192 Impact Factor

Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.

Hypertens Pregnancy 2019 Feb 13;38(1):58-63. Epub 2019 Feb 13.

a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil.

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.

Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.

Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. Read More

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http://dx.doi.org/10.1080/10641955.2019.1577435DOI Listing
February 2019
3 Reads

T lymphocytes in the third trimester decidua in preeclampsia.

Hypertens Pregnancy 2019 Feb 11;38(1):52-57. Epub 2019 Feb 11.

c Department of Pathology, Faculty of Medicine , University of Nis , Nis , Serbia.

Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia.

Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. Read More

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http://dx.doi.org/10.1080/10641955.2019.1575393DOI Listing
February 2019
3 Reads

New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia.

Hypertens Pregnancy 2019 Feb 1;38(1):41-51. Epub 2019 Feb 1.

c Fertility and Infertility Research Center , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.

Objective: Dysregulation of lncRNAs and the absence of coordination between them could affect the normal placentation, uteroplacental circulation, and endothelial cell function. All these misfunctions can finally lead to preeclampsia.

Methods:  In the present review, we discuss current literature (till May 2018) about lncRNAs expression and function in the placenta, trophoblast cells, and decidua. Read More

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http://dx.doi.org/10.1080/10641955.2019.1573252DOI Listing
February 2019
2 Reads
1.192 Impact Factor

A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia.

Hypertens Pregnancy 2019 Feb 3;38(1):20-31. Epub 2019 Jan 3.

a Department of Obstetrics , Chongqing Health Center for Women and Children , Chongqing , P.R. China.

Previous observations investigated the association of tumor necrosis factor-α (TNF-α), FAS and FASL polymorphisms with the risk of pre-eclampsia (PE). Conflicting results, however, were obtained. In this study, we aimed to evaluate the association between TNF-α -308 A/G, -850 C/T, -238 A/G, FAS -670 A/G, and FASL -844 C/T and PE risk using a meta-analysis. Read More

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http://dx.doi.org/10.1080/10641955.2018.1543432DOI Listing
February 2019
3 Reads

Correlation between uterine artery Doppler and the sFlt-1/PlGF ratio in different phenotypes of placental dysfunction.

Hypertens Pregnancy 2019 Feb 28;38(1):32-40. Epub 2018 Nov 28.

a Department of Perinatology, Division of Obstetrics and Gynecology , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Objective: To explore correlations between the sFlt-1/PlGF ratio and uterine arteries (UtA) Doppler indexes in placental dysfunction-related disorders (PDD).

Methods: We prospectively included women with a singleton pregnancy with preeclampsia (PE) only (n = 22), preeclampsia with fetal growth restriction (FGR) (n = 32), FGR only (n = 12), or normal pregnancy (n = 29).

Results: In PDDs, significantly positive correlations between the sFlt-1/PlGF ratio and the mean UtA pulsatility (mPI-UtA), as well as the resistance index (mRI-UtA) were found (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1550579DOI Listing
February 2019
3 Reads

Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease.

Hypertens Pregnancy 2019 Feb 2;38(1):13-19. Epub 2018 Nov 2.

c Department of Obstetrics and Gynecology , Health Sciences University, Zeynep Kamil Maternity and Children's Training and Research Hospital , İstanbul , Turkey.

Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies.

Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women.

Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1540702DOI Listing
February 2019
5 Reads

Investigation of elevation as a risk factor for hypertensive disorders of pregnancy among Colorado women between 2007 and 2015.

Hypertens Pregnancy 2019 Feb 1;38(1):1-12. Epub 2018 Nov 1.

b Department of Epidemiology , Colorado School of Public Health , Aurora , Colorado , USA.

Objective: The purpose of this study is to determine the association between high elevation and hypertensive disorders of pregnancy (HDP).

Methods: Retrospective cohort study using Colorado birth certificate data to compare HDP at high (≥8,000 ft), moderate (4,501-7,999 ft), or low (≤4,500 ft) elevation using logistic regression.

Results: Among the cohort (n = 314,431), 3. Read More

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http://dx.doi.org/10.1080/10641955.2018.1538378DOI Listing
February 2019
2 Reads

Serum neopterin levels in women with preeclampsia: a systematic review.

Hypertens Pregnancy 2018 Nov 9;37(4):220-226. Epub 2018 Oct 9.

c 1st dpt of Obstetrics and Gynecology , Alexandra University Hospital, National and Kapodistrian University of Athens , Athens , Greece.

Objective: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Several studies suggest its association with preeclampsia and the purpose of the present study is to evaluate this assumption.

Methods: We searched the Medline (1992-2018), Scopus (1993-2018) and Google Scholar (1993-2018) databases. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1526300DOI Listing
November 2018
4 Reads

Maternal levels of growth differentiation factor-15 in patients with preeclampsia.

Hypertens Pregnancy 2018 Nov 6;37(4):192-196. Epub 2018 Oct 6.

a Department of Obstetrics and Gynecology , Kanuni Sultan Suleyman Research and Training Hospital , Istanbul , Turkey.

Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE).

Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524477DOI Listing
November 2018
10 Reads

Peripheral arterial tonometry and angiogenic biomarkers in preeclampsia.

Hypertens Pregnancy 2018 Nov 4;37(4):197-203. Epub 2018 Oct 4.

a Institute of Clinical Chemistry and Biochemistry , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Objective: To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future.

Methods: Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay.

Results: Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524478DOI Listing
November 2018
2 Reads

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy.

Hypertens Pregnancy 2018 Nov 2;37(4):175-181. Epub 2018 Oct 2.

a Department Obstetrics & Gynecology, DR. Soetomo - UNAIR Hospital , Universitas Airlangga , Surabaya , Indonesia.

Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP).

Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). Read More

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http://dx.doi.org/10.1080/10641955.2018.1494187DOI Listing
November 2018
17 Reads

Serial profile of flow-mediated dilatation in primigravida for prediction of preeclampsia and gestational hypertension.

Hypertens Pregnancy 2018 Nov 1;37(4):212-219. Epub 2018 Oct 1.

a Department of Physiology , Government Medical College and Hospital , Chandigarh , India.

Objective: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE).

Methods: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524480DOI Listing
November 2018
10 Reads
1.192 Impact Factor

Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output.

Hypertens Pregnancy 2018 Nov 26;37(4):204-211. Epub 2018 Sep 26.

a Department of Epidemiology, Graduate School of Public Health , University of Pittsburgh , Pittsburgh , PA , USA.

Objective: To assess brachial artery distensibility and associated factors in healthy primigravidas.

Methods: We assessed brachial artery distensibility using the DynaPulse 5,000A in 37 women each trimester, and 6-8 weeks and 1-5 years postpartum. Associations with physical and cardiometabolic measures were considered. Read More

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https://www.tandfonline.com/doi/full/10.1080/10641955.2018.1
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http://dx.doi.org/10.1080/10641955.2018.1524479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330891PMC
November 2018
23 Reads

Arterial stiffness during controlled ovarian hyperstimulation and early pregnancy in women exposed to assisted reproduction.

Hypertens Pregnancy 2018 Nov 21;37(4):182-191. Epub 2018 Sep 21.

c Cura Mödravård, Institution of Clinical Sciences Malmö , Lund University , Malmö , Sweden.

Introduction: Female sex hormones have vasorelaxing effects in non-pregnant and pregnant women. We aimed to investigate the effect of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), and early pregnancy, on arterial stiffness as assessed by digital pulse wave analysis (DPA), hypothesizing reduced arterial stiffness as an effect of increased estrogen levels.

Material And Methods: A total of 68 women undergoing IVF were examined with DPA before conception and during IVF treatment with COH and embryo transfer (ET), and in gestational week seven in 19 women who became pregnant. Read More

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http://dx.doi.org/10.1080/10641955.2018.1516225DOI Listing
November 2018
2 Reads

The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes.

Hypertens Pregnancy 2018 Aug 24;37(3):118-125. Epub 2018 Jul 24.

k Department of Obstetrics and Gynecology , The Second Hospital of Hebei Medical University , Shijiazhuang , China.

Background: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population.

Study Design: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria < 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1487564DOI Listing
August 2018
4 Reads

Association between hypertensive disorders complicating pregnancy and risk of placenta accreta: a meta-analysis and systematic review.

Hypertens Pregnancy 2018 Aug 24;37(3):168-174. Epub 2018 Jul 24.

a Department of Obstetrics , Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan , Foshan , Guangdong , China.

Objective: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498880DOI Listing
August 2018
12 Reads
1.192 Impact Factor

Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study.

Hypertens Pregnancy 2018 Aug 22;37(3):137-143. Epub 2018 Jul 22.

b Department of Medical Biochemistry, Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications.

Methods: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Read More

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http://dx.doi.org/10.1080/10641955.2018.1494188DOI Listing
August 2018
22 Reads
1.192 Impact Factor

Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.

Hypertens Pregnancy 2018 Aug 19;37(3):154-159. Epub 2018 Jul 19.

b Sleep Disorders Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Objective: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia.

Methods: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498879DOI Listing
August 2018
16 Reads

Urinary clusterin and glutathione-s-transferase levels in HIV positive normotensive and preeclamptic pregnancies.

Hypertens Pregnancy 2018 Aug 19;37(3):160-167. Epub 2018 Jul 19.

a Optics and Imaging Centre, Doris Duke Medical Research Institute, College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.

Objective: To determine the level and effect of urinary clusterin (CLU) and glutathione-s-transferase (GST) proteins in normotensive and preeclamptic pregnant women with HIV infection.

Methods: The urine concentration of CLU and GST in normotensive (n = 38) and preeclamptic pregnant (n = 38) women stratified by HIV status were estimated using the Bio-Plex® Pro immunoassay.

Results: Across the group, a significant down-regulation of CLU (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2018.1498881DOI Listing
August 2018
3 Reads

Serum magnesium level in the first trimester of pregnancy as a predictor of pre-eclampsia - a pilot study.

Hypertens Pregnancy 2018 Aug 18;37(3):144-153. Epub 2018 Jul 18.

a Faculty of Medicine, Department of Pathophysiology and Laboratory Medicine , University of Novi Sad , Novi Sad , Serbia.

Objectives: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE).

Methods: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 342). Read More

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http://dx.doi.org/10.1080/10641955.2018.1494189DOI Listing
August 2018
9 Reads

Uterine artery flow velocity waveforms before and after delivery in hypertensive disorders of pregnancy near term.

Hypertens Pregnancy 2018 Aug 18;37(3):131-136. Epub 2018 Jul 18.

a Department of Obstetrics and Gynecology , University of Tennessee Health Science Center , Memphis , TN , USA.

Objective: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term.

Methods: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Read More

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http://dx.doi.org/10.1080/10641955.2018.1493495DOI Listing
August 2018
6 Reads

The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension.

Hypertens Pregnancy 2018 Aug 17;37(3):126-130. Epub 2018 Jul 17.

a Division of Maternal Fetal Medicine , The University of Texas Medical Branch , Galveston , TX , USA.

Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Read More

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http://dx.doi.org/10.1080/10641955.2018.1493494DOI Listing
August 2018
3 Reads

First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk.

Hypertens Pregnancy 2018 Aug 12;37(3):111-117. Epub 2018 Jun 12.

d Department of Pediatrics, Faculty of Medicine , Menoufia University , Shibin El-Kom City , Egypt.

Objective: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk.

Methods: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236). Test validity of MPV and serum uric acid was the primary outcome measure. Read More

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http://dx.doi.org/10.1080/10641955.2018.1483508DOI Listing
August 2018
21 Reads

Morphological and structural changes of umbilical veins and clinical significance in preeclampsia.

Hypertens Pregnancy 2018 Aug 7;37(3):105-110. Epub 2018 May 7.

a Morphological Laboratory , Hainan Medical University , Haikou , China.

Objective: Preeclampsia is a common complication of pregnancy that is characterized by high blood pressure. Preeclampsia can have both negative maternal and fetal effects, including impaired fetal development from reduced placental perfusion. Because umbilical vessels provide fetal blood supply, morphological changes in these vessels can critically affect fetal function. Read More

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http://dx.doi.org/10.1080/10641955.2017.1420799DOI Listing
August 2018
5 Reads

Association between serum CA125 levels in preeclampsia and its severity among women in Lagos, South-West Nigeria.

Hypertens Pregnancy 2018 May 2;37(2):93-97. Epub 2018 May 2.

b Obstetrics & Gynaecology , College of Medicine University of Lagos , Lagos , Nigeria.

Background: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460667DOI Listing
May 2018
12 Reads
1.192 Impact Factor

Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk.

Hypertens Pregnancy 2018 May 1;37(2):87-92. Epub 2018 May 1.

a Department of Epidemiology and Biostatistics, School of Public Health , Tongji Medical College of Huazhong University of Science & Technology , Wuhan , China.

Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women.

Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460666DOI Listing
May 2018
8 Reads

Cardiovascular risk after preeclampsia: The effect of communicating risk factors on intended healthy behavior.

Hypertens Pregnancy 2018 May 25;37(2):98-103. Epub 2018 Apr 25.

a Department of Obstetrics & Gynecology , VU University Medical Center , Amsterdam , The Netherlands.

Objective: We studied the effect of communicating cardiovascular risk factors on intended healthy behavior in women with a history of preeclampsia or uncomplicated pregnancy.

Methods: Intention for healthy behavior was assessed before and after cardiovascular risk assessment. Changes were calculated for women with and without cardiovascular risk factors. Read More

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http://dx.doi.org/10.1080/10641955.2018.1460668DOI Listing
May 2018
5 Reads

Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.

Hypertens Pregnancy 2018 May 16;37(2):68-80. Epub 2018 Apr 16.

a Research center , Centre hospitalier universitaire de Québec , Québec , Canada.

Objectives: The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia.

Methods: 131 pregnant women considered at risk of preeclampsia based on uterine artery Doppler ultrasound were divided into two groups (HFHT or low flavanol and theobromine chocolate (LFLT). Acute changes in plasma flavanol and theobromine, peripheral arterial tonometry and BP were evaluated at randomization (0, 60 and 120 min after a single 40-g dose of chocolate) and again 6 and 12 weeks after daily 30-g chocolate intake. Read More

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http://dx.doi.org/10.1080/10641955.2018.1446977DOI Listing
May 2018
14 Reads

Relation of locus 1p13 rs646776 polymorphism with the risk of preeclampsia.

Hypertens Pregnancy 2018 May 25;37(2):81-86. Epub 2018 Mar 25.

a Faculty of Pharmacy, Department of Biochmistry , Suez Canal University , Ismailia , Egypt.

Objective: This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women.

Methods: The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Read More

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http://dx.doi.org/10.1080/10641955.2018.1454462DOI Listing
May 2018
6 Reads

Safety of a physical therapy protocol for women with preeclampsia: a randomized controlled feasibility trial.

Hypertens Pregnancy 2018 May 1;37(2):59-67. Epub 2018 Mar 1.

c Department of Gynecology and Obstretrics, Ribeirão Preto Medical School , University of São Paulo , Ribeirão Preto , Brazil.

Objective: To assess the feasibility and safety of a physiotherapy protocol applied to pregnant women with preeclampsia.

Methods: Randomized, controlled, single-blind feasibility study, with 24 hospitalized pregnant women with preeclampsia. The intervention group received one session of the physiotherapy. Read More

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http://dx.doi.org/10.1080/10641955.2018.1439059DOI Listing
May 2018
5 Reads

Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia.

Hypertens Pregnancy 2018 Feb 8;37(1):37-50. Epub 2018 Jan 8.

a Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas , Zacatecas , Mexico.

Background: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia.

Objective: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. Read More

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http://dx.doi.org/10.1080/10641955.2017.1411946DOI Listing
February 2018
19 Reads

Associations of hypertensive disorders of pregnancy and outcomes of labor induction with prostaglandin vaginal inserts.

Hypertens Pregnancy 2018 Feb 1;37(1):51-57. Epub 2018 Jan 1.

a Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology , University of California Irvine Medical Center , Orange , CA , USA.

Objective: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI).

Study Design: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery. Read More

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http://dx.doi.org/10.1080/10641955.2017.1420800DOI Listing
February 2018
8 Reads

The effect of magnesium sulfate on gene expression in maternal microvascular endothelial cells.

Hypertens Pregnancy 2018 Feb 27;37(1):30-36. Epub 2017 Nov 27.

a Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre , University of Toronto , Toronto , Ontario , Canada.

Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Read More

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http://dx.doi.org/10.1080/10641955.2017.1402924DOI Listing
February 2018
5 Reads

Relation with postpartum maternal morbidity of different types of anesthesia in preeclamptic patients.

Hypertens Pregnancy 2018 Feb 20;37(1):25-29. Epub 2017 Nov 20.

a Department of Obstetrics and Gynecology, Faculty of Medicine , Ondokuz Mayis University , Samsun , Turkey.

Objective: The aim of this study is to investigate the effect of different anesthesia types administered to patients with preeclampsia on postoperative maternal morbidities.

Methods: Medical records of pregnant women complicated with preeclampsia delivered by cesarean from January 2010 to December 2016 in our clinic were retrospectively reviewed.

Results: There was not a statistically significant difference between patients receiving spinal anesthesia and general anesthesia in terms of additional parenteral analgesic requirement at postoperative period (p = 0. Read More

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http://dx.doi.org/10.1080/10641955.2017.1402923DOI Listing
February 2018
8 Reads

Alteration in methylation level at differential methylated regions of MEST and DLK1 in fetus of preeclampsia.

Hypertens Pregnancy 2018 Feb 20;37(1):1-8. Epub 2017 Nov 20.

a Women's Hospital, School of Medicine , Zhejiang University.

Objectives: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia.

Methods: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397689DOI Listing
February 2018
11 Reads

Preeclampsia knowledge among women in Utah.

Hypertens Pregnancy 2018 Feb 15;37(1):18-24. Epub 2017 Nov 15.

a Health Science , Brigham Young University , Provo , USA.

Background: Despite the benefits of preeclampsia (PE) education in improving health outcomes, little is known about how often healthcare providers in Utah include PE in prenatal education or how much information women retain. As such, the purpose of this study was to explore PE awareness among mothers in Utah and inquire how often PE is included in prenatal education. Factors associated with PE knowledge were also investigated. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397691DOI Listing
February 2018
4 Reads

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

Hypertens Pregnancy 2018 Feb 14;37(1):9-17. Epub 2017 Nov 14.

c Ankara Universitesi, Obstetrics and Gynecology , Ankara , Turkey.

The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. Read More

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http://dx.doi.org/10.1080/10641955.2017.1397690DOI Listing
February 2018
6 Reads

Editorial Board Page EOV.

Authors:

Hypertens Pregnancy 2017 11;36(4):336

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http://dx.doi.org/10.1080/10641955.2017.1271273DOI Listing
November 2017
4 Reads