476,691 results match your criteria Hypertension in Pregnancy [Journal]


Prescription patterns of direct oral anticoagulants in pulmonary embolism: A prospective multicenter French registry.

Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.

Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.

Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More

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December 2018

Influence of hypertension on brain amyloid deposition and Alzheimer's disease signature neurodegeneration.

Neurobiol Aging 2018 Nov 16;75:62-70. Epub 2018 Nov 16.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

This study aimed to investigate the relationship of hypertension with beta-amyloid (Aβ) and neurodegeneration biomarkers of Alzheimer's disease (AD) and the modulating effect of apolipoprotein E-ε4 (APOE4). In total, 259 cognitively normal (CN) and 79 AD dementia older adults received clinical assessments including the evaluation for the presence of hypertension, [C]-Pittsburgh-compound-B-positron emission tomography, magnetic resonance imaging, and APOE genotyping. We used a clinical stage-specific approach, separately focusing on CN and AD dementia stages. Read More

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November 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

Association of allostatic load with health-related quality of life in patients with arterial hypertension: a cross-sectional analysis.

Swiss Med Wkly 2018 Dec 15;148:w14689. Epub 2018 Dec 15.

Department of Medical Psychology and Psychotherapy, Medical University of Graz, Austria / Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Austria.

Aims Of The Study: Allostatic load (AL), as a marker of cumulative stress, is associated with higher morbidity and mortality, and reduced health-related quality of life (HrQoL) in healthy adults. In patients with hypertension, AL and its association with HrQoL have not been investigated. Therefore, this study aimed to (1) explore AL in a cohort of hypertensive patients and to (2) determine its association with HrQoL, while controlling for other health-related variables. Read More

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December 2018

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

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December 2018
2 Reads

Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Hanyang hospital of Wuhan University of Science and Technology, Hanyang, Wuhan, China.

Background: Recently, the role of α-adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α-adducin rs4961 polymorphism and the likelihood of HTN.

Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Read More

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December 2018

Catecholamine Response to Exercise in Patients with Non-Obstructive Hypertrophic Cardiomyopathy.

J Physiol 2018 Dec 15. Epub 2018 Dec 15.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Yawkey Suite 5B, Boston, MA, USA.

Key Points Summary: Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle; weight gain, hypertension, hyperlipidemia, insulin resistance, coronary artery disease and increased morbidity and mortality. We show that plasma catecholamine levels remain stably low at exercise intensities below the ventilatory threshold, a parameter that can be defined during cardiopulmonary exercise testing, but rise rapidly at higher intensities of exercise. Read More

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December 2018
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Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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December 2018

Severity of obstructive sleep apnea and extension of coronary artery disease.

Sleep Breath 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Purpose: Obstructive sleep apnea (OSA) is highly prevalent among patients with coronary artery disease (CAD). The relationship between the severity of OSA and the severity of CAD has not been entirely established. The objective was to explore the type of correlation existent between the apnea-hypopnea index and the Gensini score, which provides granularity in terms of CAD extension and severity, in search of a dose-response relationship. Read More

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December 2018
2 Reads

Effects of sartans and low-dose statins on cerebral white matter hyperintensities and cognitive function in older patients with hypertension: a randomized, double-blind and placebo-controlled clinical trial.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China.

Cerebral white matter hyperintensities (WMHs) and cognitive impairment are common in elderly hypertensive patients, and more needs to be learned about their prevention and treatment. Our aim was to investigate the effect of low-dose statins on WMH and cognitive function in elderly patients undergoing antihypertensive treatment. A total of 732 elderly hypertensive patients taking hydrochlorothiazide as their baseline medication were randomized using a 2 × 2 factorial design with antihypertensive (telmisartan vs. Read More

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December 2018

Determinants of pulse pressure amplification in hypertensive and diabetic patients.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Paris-Descartes University; Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Hypertensive diabetic patients remain at high cardiovascular risk despite adequate blood pressure and glycemic control. Pulse pressure amplification (PPA) is expressed as the peripheral-to-central PP ratio and provides complementary information for use in assessing cardiovascular risk. The aim of our study was to determine the clinical and biological determinants of PPA in hypertensive and diabetic patients. Read More

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December 2018

Impact of ezetimibe on plasma lipoprotein(a) concentrations as monotherapy or in combination with statins: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep 2018 Dec 14;8(1):17887. Epub 2018 Dec 14.

Weill Cornell Medicine Qatar, Doha, Qatar.

The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess the effect of ezetimibe on plasma lipoprotein(a) concentrations. Only randomized placebo-controlled trials investigating the impact of ezetimibe treatment on cholesterol lowering that include lipoprotein(a) measurement were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to February 26, 2018). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Read More

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December 2018

Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e020759. Epub 2018 Dec 14.

Center of Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.

Objectives: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

Research Design And Methods: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Read More

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December 2018

Safety and Activity of Sorafenib in Addition to Vinflunine in Post-Platinum Metastatic Urothelial Carcinoma (Vinsor): Phase I Trial.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.

Lessons Learned: First trial to report safety and activity of the microtubule inhibitor vinflunine plus the tyrosine kinase inhibitor sorafenib in post-platinum metastatic urothelial cancer (mUC) patients.A recommended phase II dose was identified for the treatment combination of vinflunine plus sorafenib, with main adverse events including fatigue, febrile neutropenia, neutropenia, hypertension, and hyponatremia.An overall response rate of 41% to second-line vinflunine plus sorafenib treatment in patients with platinum-resistant mUC was confirmed. Read More

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December 2018

An overview of the 6th World Symposium on Pulmonary Hypertension.

Eur Respir J 2018 Dec 14. Epub 2018 Dec 14.

Univ. Paris-Sud, AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Service de Pneumologie, Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Hôpital de Bicêtre, Le Kremlin Bicêtre, France.

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December 2018

Treatment of chronic hepatitis C virus infection in Rwanda with ledipasvir-sofosbuvir (SHARED): a single-arm trial.

Lancet Gastroenterol Hepatol 2018 Dec 10. Epub 2018 Dec 10.

Stanford University, Palo Alto, CA, USA.

Background: Limited treatment data are available for hepatitis C virus (HCV) in sub-Saharan Africa, especially for genotype 4. Our objective was to establish the safety and efficacy of ledipasvir-sofosbuvir for chronic HCV genotype 1 or 4 infection in adults in Rwanda.

Methods: We did a single-arm trial to evaluate the safety and efficacy of ledipasvir-sofosbuvir in Rwandan adults with chronic HCV infection at a single study site (Rwanda Military Hospital, Kigali, Rwanda). Read More

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December 2018

Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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December 2018

Characterization of Right Ventricular Deformation in Pulmonary Arterial Hypertension Using Three-Dimensional Principal Strain Analysis.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: Pulmonary arterial hypertension (PAH) can cause maladaptive right ventricular (RV) functional changes associated with adverse prognosis that are challenging to accurately quantify noninvasively. The aim of this study was to explore principal strain (PS) with contraction angle analysis using three-dimensional echocardiography to characterize RV deformation changes in patients with PAH.

Methods: Three-dimensional echocardiography was performed in 37 patients with PAH and 20 healthy control subjects with two-component (primary and secondary) PS and principal contraction angle analysis. Read More

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December 2018

Malnutrition according to ESPEN definition predicts long-term mortality in general older population: Findings from the EPIDOS study-Toulouse cohort.

Clin Nutr 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurosciences and Aging, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

Background: The European Society of Clinical Nutrition and Metabolism (ESPEN) has developed a consensus definition of malnutrition. This study aimed to determine the prevalence of malnutrition according to the ESPEN definition in otherwise healthy community-dwelling older women and to explore its value for predicting long-term mortality in this population.

Methods: This prospective population-based cohort study included 181 women (age ≥75 years) from a subsample of the EPIDémiologie de l'OStéoporose (EPIDOS) study participants from Toulouse. Read More

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December 2018

Incidence and Outcomes of Acute Myocardial Infarction During Motor Vehicle Accident Related Hospitalizations.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiovascular Disease, West Virginia University, Morgantown, West Virginia.

Data on Motor Vehicle Accidents (MVA) associated acute myocardial infarctions (AMI) are scares. We aimed to examine the frequency, characteristics, and outcomes of AMI among patients admitted with MVA. Patients hospitalized with Motor Vehicle Traffic Accidents (ICD-9-CM codes e810-e819) in 2003 to 2014 were identified in the national inpatient sample. Read More

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December 2018
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Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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December 2018

Prevalence, awareness, control and determinants of hypertension among primary health care professional nurses in Eastern Cape, South Africa.

Afr J Prim Health Care Fam Med 2018 Nov 22;10(1):e1-e5. Epub 2018 Nov 22.

Department of Nursing Science, Faculty of Health Sciences, University of Fort Hare.

Background:  Nurses in primary health care settings are key stakeholders in the diagnosis and management of hypertensive patients. Unfortunately, the working conditions of nurses predispose them to stress, long hours of work, shift duties and unhealthy diets, which are drivers of hypertension. Yet nurses are often overlooked in health screening exercises, primarily because they are assumed to be informed and 'healthy'. Read More

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November 2018

Body Mass Index is Strongly Associated with Hypertension: Results from the Longevity Check-up 7+ Study.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Fondazione Policlinico Universitario "Agostino Gemelli", Università Cattolica del Sacro Cuore, L.go F. Vito 8, 00168 Rome, Italy.

The present study was undertaken to provide a better insight into the relationship between different levels of body mass index (BMI) and changing risk for hypertension, using an unselected sample of participants assessed during the Longevity Check-up 7+ (Lookup7+) project. Lookup7+ is an ongoing cross-sectional survey started in June 2015 and conducted in unconventional settings (i.e. Read More

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December 2018

Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate.

Biomed Pharmacother 2019 Jan 27;109:2155-2172. Epub 2018 Nov 27.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address:

Cardiovascular complications are considered one of the leading causes of morbidity and mortality among diabetic patients. Diabetic cardiomyopathy (DCM) is a type of cardiovascular damage presents in diabetic patients independent of the coexistence of ischemic heart disease or hypertension. It is characterized by impaired diastolic relaxation time, myocardial dilatation and hypertrophy and reduced systolic and diastolic functions of the left ventricle. Read More

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January 2019
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Endothelium-dependent and endothelium-independent vasorelaxant effects of tiliacorinine 12'-O-acetate and mechanisms on isolated rat aorta.

Biomed Pharmacother 2019 Jan 26;109:2090-2099. Epub 2018 Nov 26.

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Tiliacorinine 12'-O-acetate is a modified analog of Tiliacorinine, a major compound in Tiliacora triandra. The present study explored the vasorelaxation property of tiliacorinine 12'-O-acetate and its mechanism in isolated rat aorta using the organ bath technique. Tiliacorinine 12'-O-acetate exhibited concentration-dependent (10-10 M) vasorelaxation in endothelium-intact rings (E = 93. Read More

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January 2019
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2.023 Impact Factor

Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A review.

Biomed Pharmacother 2019 Jan 26;109:2054-2061. Epub 2018 Nov 26.

Department of Ultrasound, Fuling Central Hospital of Chongqing City, Chongqing, China. Electronic address:

Hepatocellular carcinoma (HCC) is one of the most common cancers and has a high mortality rate in less developed countries, especially in China. Galangin (GA), one of the most important and naturally active flavonoids, extracted primarily from the root of Alpinia officinarum Hance, has been demonstrated to be effective in the treatment of HCC. It is a substance with defensive actions and a broad range of biological properties, including inhibitory effects on bacteria, fungi, viruses, the control of hypertension and diabetes, and chemoprevention of several cancers. Read More

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January 2019

Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction.

Biomed Pharmacother 2019 Jan 26;109:1907-1914. Epub 2018 Nov 26.

Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

NADPH oxidases (Noxs) 1/4 dual inhibitor GKT137831 prevents hypertensive cardiac remodelling in angiotensin II-infused transgenic mice with cardiomyocyte-specific human Nox4 (c-hNo x 4 Tg); however, further research is still required to determine the beneficial role of GKT137831 in hypertensive cardiac remodelling in other types of hypertensive models because this hypertensive model is insufficient to mimic the complicated pathological mechanisms of hypertension. A disintegrin and metalloprotease 17 (ADAM17) promotes the shedding of tumour necrosis factor α (TNF-α), TNF-α receptor, interleukin 1 receptor-II and interleukin 6 (IL-6) receptor from cells, thereby mediating the signalling pathways induced by corresponding proinflammatory cytokines. This study aimed to determine whether GKT137831 prevents hypertensive cardiac remodelling and its mechanisms of action in the rats with abdominal artery coarctation (AAC). Read More

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January 2019

A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it.

Biomed Pharmacother 2019 Jan 26;109:1867-1875. Epub 2018 Nov 26.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China. Electronic address:

Hypertension crisis is a severe disease and needs emergency treatment in clinic. It is an important task to discover novel drugs which could lower the blood pressure steadily and quickly. However, animal models for screening anti-hypertensive crisis agents are unsatisfactory. Read More

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January 2019

MicroRNA-150 relieves vascular remodeling and fibrosis in hypoxia-induced pulmonary hypertension.

Biomed Pharmacother 2019 Jan 21;109:1740-1749. Epub 2018 Nov 21.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China. Electronic address:

Pulmonary hypertension (PH) is a dangerous disease, featured by pulmonary vascular remodeling. Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs) plays crucial roles in this process. MicroRNA-150 (miR-150) level has been found to be reduced in patients with PH, and correlated with the poor survival. Read More

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January 2019

New fatty dihydropyridines present cardioprotective potential in H9c2 cardioblasts submitted to simulated ischemia and reperfusion.

Biomed Pharmacother 2019 Jan 14;109:1532-1540. Epub 2018 Nov 14.

Programa de Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:

Nifedipine is a calcium channel blocker dihydropyridine that has been used in the treatment of hypertension. The production of reactive species and calcium overload are the main contributors to myocardial ischemia-reperfusion (I / R) injury. We investigated the ability of novel dihydropyridines (DHPs) to improve the effect of protecting against the injury induced by ischemia and reperfusion in cardioblasts when compared to nifedipine. Read More

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January 2019

AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats.

Biomed Pharmacother 2019 Jan 9;109:1319-1326. Epub 2018 Nov 9.

Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:

Perivascular inflammation, vascular luminal area reduction and hemodynamics changes are important pathophysiologic bases of pulmonary hypertension (PH). In this study, PH was induced by an intraperitoneal single injection of monocrotaline (MCT, 60 mg/kg). Alginate oligosaccharides (AOS), one of the most famous marine drugs, provided protections in the perivascular inflammation, vascular luminal area reduction and hemodynamics changes of the PH rat induced by MCT. Read More

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January 2019

Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada.

Background:  Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.

Objective:  To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension (GH) and preeclampsia.

Study Design:  Among 1,909 pregnant women participating in the maternal-infant research on environmental chemicals (MIREC) study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Read More

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December 2018
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Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

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December 2018
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Risk factors for death among patients with Chikungunya virus infection during the outbreak in northeast Brazil, 2016-2017.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará-UFC. Fortaleza, Ceará, Brazil.

Background: Chikungunya virus (CHIKV) infection is a current public health problem. The aim of this study was to investigate risk factors for death among patients with CHIKV infection during a large epidemic in northeast Brazil.

Methods: This is a cross-sectional study with all registered cases of CHIKV in Ceara, Brazil, during 2016-2017. Read More

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December 2018

Social and early life adversity and chronic health conditions among Tunisian adults.

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Duluth Medical Research Institute, University of Minnesota, Duluth, MN, USA.

Early life adversities (ELAs) are shown as significant risk factors for chronic health conditions (CHCs). ELAs include multiple types of abuse such as the social abuse (peer, community, and collective violence). The purpose is to describe the relationship between childhood social abuse and chronic conditions in adulthood among a sample of adults in Tunisia and to investigate the role of obesity and tobacco use as mediators of this association. Read More

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December 2018
2 Reads

Arterial and pulmonary hypertension: risk assessment and current pharmacological and interventional management.

Eur Heart J 2018 Dec;39(47):4127-4131

Imperial College and Consultant and Director of Research, Education & Development, Royal Brompton and Harefield Hospital Trust, London, UK.

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December 2018
1 Read

Clinical Implications.

Authors:

Hypertension 2018 Jul;72(1)

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CE: Addressing Food Insecurity in Vulnerable Populations.

Am J Nurs 2018 Dec 12. Epub 2018 Dec 12.

Heather L. Flores is an NP at the John and Ella Byrd McCain Health and Counseling Center, Alabama A&M University, Huntsville. Azita Amiri is an assistant professor of nursing at the University of Alabama, Huntsville. Contact author: Heather L. Flores, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

A review of risk factors, health effects, screening, and resources. ABSTRACT: Food insecurity affects people of all ages, in every area in which nurses work or volunteer. The U. Read More

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December 2018
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Morbidity and mortality after transjugular intrahepatic portosystemic shunt placement in patients with cirrhosis.

Eur J Gastroenterol Hepatol 2018 Dec 13. Epub 2018 Dec 13.

Hepatology and Liver Transplant Unit, Department of Medical Area (DAME).

Objectives: Transjugular intrahepatic portosystemic shunt (TIPS) is adopted to treat refractory complications of portal hypertension, such as variceal bleeding and ascites. This study aimed to assess predictors of hepatic encephalopathy (HE) development and cumulative transplant-free survival after TIPS placement in patients with cirrhosis complicated by refractory ascites and major gastroesophageal bleeding.

Materials And Methods: Sixty-three cirrhotic patients who underwent TIPS positioning as a secondary prophylaxis of major upper gastroesophageal bleeding (N=30) or to control refractory ascites (N=33) were enrolled. Read More

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December 2018

Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin angiotensin system.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Center for Nutritional Sciences, University of Kentucky, United States.

The deletion of the prorenin receptor (PRR) in adipose tissue elevates systolic blood pressure (SBP) and circulating soluble form of PRR (sPRR) in male mice fed a high-fat diet (HF). However, sex differences in the contribution of adipose-PRR and sPRR to the regulation of the renin-angiotensin system (RAS) in key organs for blood pressure control are undefined. Therefore, we assessed blood pressure and the systemic and intrarenal RAS status in adipose-PRR KO female mice. Read More

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December 2018
1 Read

Pulmonary hypertension in patients with a history of intravenous drug use.

Curr Med Res Opin 2018 Dec 14:1-14. Epub 2018 Dec 14.

a Cardiovascular Department , John Hunter Hospital , Newcastle NSW , Australia.

Objective: Pulmonary hypertension may be a consequence of intrinsic elevation in pulmonary vasculature resistance or complicate numerous other conditions affecting the cardiac and respiratory systems. In this review we sought to explore the relationship between pulmonary hypertension and intravenous drug use.

Methods: A narrative review was conducted using PubMed MeSH search with further papers were identified using a standard PubMed search with relevant key terms and various synonyms. Read More

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December 2018
1 Read

Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.

Clin Lab 2018 Oct;64(11)

Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Read More

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October 2018
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HeartMate 3 left ventricular assist device minimally invasive off-pump implantation.

Authors:
Paolo Centofanti

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

With advancements in mechanical circulatory support technology, and limitations in donor supply for heart transplantation, the use of left ventricular assist devices (LVADs) has increased significantly in recent years. Multiple studies have shown that minimally invasive cardiac surgery can improve outcomes, with shorter hospital stays, decreased morbidity, faster recovery and ambulation, and lower total hospital costs. The current generation of centrifugal continuous-flow pumps is miniaturized and makes minimally invasive approaches increasingly practicable. Read More

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December 2018
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Metabolic Syndrome in Dutch Patients With Bipolar Disorder: A Cross-Sectional Study.

Prim Care Companion CNS Disord 2018 Dec 6;20(6). Epub 2018 Dec 6.

Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.

Objective: To characterize the prevalence of metabolic syndrome (MetS) among Dutch patients with bipolar disorder (BD), identify factors associated with MetS, and estimate the rate of pharmacologic treatment of MetS in this population.

Methods: A cross-sectional analysis of medical records of adult patients (≥ 18 years) with BD receiving psychotropic drug treatment was performed in a Dutch psychiatric outpatient setting. MetS was determined according to National Cholesterol Education Program Adult Treatment Panel III-Adapted (NCEP ATP III-A) criteria. Read More

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December 2018
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Prospective study of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia.

Pediatr Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Section of Neonatology, Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: To evaluate the prevalence, risk factors, and optimal timing of echocardiogram for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD).

Design: In this prospective study, infants with gestational age (GA) <30 weeks admitted to a tertiary NICU between July 2015 and June 2017 who required positive pressure ventilation or oxygen therapy at ≥28 days of life were evaluated with serial echocardiograms at study enrollment (4-6 weeks of age), 32 weeks (only for ≤25 weeks), 36, and 40 weeks post-menstrual age (PMA) for PH.

Results: Of 126 infants (mean birth weight 858 ± 221 g; mean GA 26. Read More

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December 2018
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A novel autosomal dominant mutation in SOX18 resulting in a fatal case of hypotrichosis-lymphedema-telangiectasia syndrome.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, California.

Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) is a rare disorder caused by autosomal recessive and autosomal dominant mutations in SOX18. This gene encodes a transcription factor involved in the regulation and development of the human vasculature, lymphatic, and integumentary systems. Individuals with HLTS develop varying degrees of hypotrichosis, lymphedema, and telangiectasias. Read More

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December 2018
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The clinical value of automated office blood pressure: What is the latest evidence on attended vs unattended automated readings in clinical practice?

J Clin Hypertens (Greenwich) 2018 Dec 14. Epub 2018 Dec 14.

Cardiology Department, Georgetown University and Veterans Affairs Medical Center, Washington, District of Columbia.

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December 2018
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Comparison of two different radiofrequency ablation systems for renal artery denervation: Evaluation of short-term and long-term follow up.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia.

Objectives: To assess the clinical efficacy of renal artery denervation (RAD) in our center and to compare the efficacy of two different radiofrequency (RF) systems.

Background: Several systems are available for RF renal denervation. Whether there is a difference in clinical efficacy among various systems remains unknown. Read More

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December 2018
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The presence of varices in patients after hepatitis C eradication predicts deterioration in the FIB-4 index.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Aims: The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virological response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and FIB-4 index after SVR was achieved by direct-acting antiviral (DAA) treatment. Read More

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December 2018