27,311 results match your criteria Hypertension and Pregnancy


Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices.

Case Rep Obstet Gynecol 2019 14;2019:5702983. Epub 2019 Mar 14.

Department of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.

Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. Read More

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http://dx.doi.org/10.1155/2019/5702983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437724PMC

A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Education and Support for Regional Medicine, Tohoku University Hospital, Japan.

We present a report of a 29-year-old woman with non-dipper type refractory hypertension due to the vascular compression of the medulla oblongata. The patient was diagnosed with hypertension at 17 years of age and underwent emergency Caesarean section at 26 weeks of gestation during 2 pregnancies due to severe high blood pressure. We suspected medullary compression by the curved posterior inferior cerebellar artery as the cause of her intractable hypertension, and she underwent Jannetta's decompression surgery. Read More

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http://dx.doi.org/10.2169/internalmedicine.2382-18DOI Listing

The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies.

Int J Obes (Lond) 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Objecive: Women with twins have an a priori increased risk for many of the complications associated with maternal obesity. Thus, the impact of maternal obesity in twins may differ from that reported in singletons. In addition, given the increased metabolic demands in twin pregnancies, the impact of maternal underweight may be greater in twin compared with singleton gestations. Read More

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http://dx.doi.org/10.1038/s41366-019-0362-8DOI Listing
April 2019
1 Read

Risk factors and potential protective factors of pregnancy-induced hypertension in China: A cross-sectional study.

J Clin Hypertens (Greenwich) 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Henan, China.

A cross-sectional study was conducted to the reported factors and assesses possible protective factors for pregnancy-induced hypertension (PIH) in China. The data of pregnant women who delivered between October 2016 and September 2017 were collected from a birth registry. The primary outcome was the occurrence of PIH. Read More

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http://dx.doi.org/10.1111/jch.13541DOI Listing
April 2019
1 Read

Hypertension in pregnancy: Role of body mass index, insulin resistance, aldosterone, and calcium homeostasis.

J Clin Hypertens (Greenwich) 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine-Endocrinology, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/jch.13538DOI Listing
April 2019
1 Read

Acute kidney injury in patients with HELLP syndrome.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: To evaluate the risk factors and renal prognosis of acute kidney injury (AKI) in patients with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.

Methods: Women with HELLP syndrome over a 15-year period at Peking Union Medical College Hospital, China, were retrospectively studied.

Results: A total of 108 patients with HELLP syndrome were included. Read More

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http://link.springer.com/10.1007/s11255-019-02111-7
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http://dx.doi.org/10.1007/s11255-019-02111-7DOI Listing
April 2019
3 Reads

Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome.

Exp Ther Med 2019 May 13;17(5):3682-3688. Epub 2019 Mar 13.

Ward 1, Department of Gynecology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.

Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome were investigated. A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. Read More

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http://dx.doi.org/10.3892/etm.2019.7385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447783PMC
May 2019
1 Read

Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration.

Int J Womens Health 2019 27;11:213-222. Epub 2019 Mar 27.

Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland,

Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications of pregnancy. Previous studies by our group have shown that PP13 lowers blood pressure in pregnant rats, increases the size and weight of pups and placentas, and induces vasodilation of resistance arteries through endothelial signaling pathways involving endothelial nitric oxid synthase and prostaglandin.

Methods: In the present study, the effect of PP13 was investigated in nonpregnant female Sprague Dawley rats (n=27). Read More

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https://www.dovepress.com/placental-protein-13-pp13-stimulat
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http://dx.doi.org/10.2147/IJWH.S188303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443218PMC
March 2019
2 Reads

Cardiac Biomarkers and Cardiovascular Outcome in Children with Chronic Kidney Disease.

Iran J Kidney Dis 2019 Mar;13(2):120-128

Department of Pediatrics, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Introduction: Myocardial dysfunction is a leading cause of mortality in chronic kidney disease (CKD) children specially those on regular hemodialysis. Cardiac biomarkers play a key role for early detection of myocardial injury. We aim to clarify the prognostic role of circulating cardiac biomarkers, heart type fatty acid binding protein (H-FABP) and pregnancy associated plasma protein-A (PAPP-A) in CKD children on regular hemodialysis. Read More

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March 2019
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Midwives', Obstetricians', and Recently Delivered Mothers' Perceptions of Remote Monitoring for Prenatal Care: Retrospective Survey.

J Med Internet Res 2019 Apr 15;21(4):e10887. Epub 2019 Apr 15.

Limburg Clinical Research Program, Mobile Health Unit, Hasselt University, Diepenbeek, Belgium.

Background: The Pregnancy Remote Monitoring (PREMOM) study enrolled pregnant women at increased risk of developing hypertensive disorders of pregnancy and investigated the effect of remote monitoring in addition to their prenatal follow-up.

Objective: The objective of this study was to investigate the perceptions and experiences of remote monitoring among mothers, midwives, and obstetricians who participated in the PREMOM study.

Methods: We developed specific questionnaires for the mothers, midwives, and obstetricians addressing 5 domains: (1) prior knowledge and experience of remote monitoring, (2) reactions to abnormal values, (3) privacy, (4) quality and patient safety, and (5) financial aspects. Read More

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http://dx.doi.org/10.2196/10887DOI Listing
April 2019
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Role of Social Support and Spouse Abuse in Low Birth Weight: A Case-control Study from Puducherry, India.

Indian J Community Med 2019 Jan-Mar;44(1):12-16

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Low birth weight (LBW) is a major cause of neonatal morbidity and mortality. In addition to medical/clinical risk factors, various socio-demographic factors also have an impact on birth weight.

Objective: The objective of the study is to determine the association of antenatal social support and spouse abuse during pregnancy with LBW in Urban areas of Puducherry. Read More

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http://dx.doi.org/10.4103/ijcm.IJCM_114_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437797PMC
April 2019
1 Read

Infant milk-feeding practices and cardiovascular disease outcomes in offspring: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):800S-816S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) lower versus higher intensities of human milk fed to mixed-fed infants with intermediate and endpoint cardiovascular disease (CVD) outcomes in offspring.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

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https://academic.oup.com/ajcn/article/109/Supplement_7/800S/
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http://dx.doi.org/10.1093/ajcn/nqy332DOI Listing
March 2019
2 Reads
6.770 Impact Factor

Dietary patterns before and during pregnancy and maternal outcomes: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):705S-728S

Food and Nutrition Service, USDA, Alexandria, VA.

Background: Hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) are common maternal complications during pregnancy, with short- and long-term sequelae for both mothers and children.

Objective: Two systematic review questions were used to examine the relation between 1) dietary patterns before and during pregnancy, 2) HDP, and 3) GDM.

Methods: A search was conducted from January 1980 to January 2017 in 9 databases including PubMed, Embase, and Cochrane. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcn/nqy216DOI Listing
March 2019
3 Reads
6.770 Impact Factor

[Risk factors of retinopathy of prematurity in extremely low birth weight infants by strictly controlling oxygen inhalation after birth].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):280-288

The Affiliated Eye Hospital of Whenzhou Medical University at HangZhou, HangZhou 310020, China.

To observe the incidence and severity of retinopathy of prematurity (ROP) in extremely low birth weight (ELBW) infants by strictly controlling the risk factors of ROP, such as oxygen inhalation after birth, to explore the related factors of ROP in ELBW infants. This was a cross-sectional study. 166 ELBW infants underwent neonatal screening were enrolled in this study, whose birth weight was less than 1 000 g. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.010DOI Listing
April 2019
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Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.

Am J Nephrol 2019 Apr 12;49(5):386-396. Epub 2019 Apr 12.

Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara Health Sciences Center, Guadalajara, Mexico,

Background: Chronic kidney disease (CKD) is a global public health problem and is linked to adverse outcomes during pregnancy; the high prevalence of CKD (3-6%) in women of childbearing age is of particular relevance in emerging countries where CKD prevalence is higher and resources are limited. Although CKD is a public health problem in Mexico, there is scant information on outcomes in pregnant CKD women in this country. We report maternal-fetal outcomes in a prospective cohort of poor, CKD pregnant women, and compare results with those of pregnant women without CKD. Read More

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https://www.karger.com/Article/FullText/499964
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http://dx.doi.org/10.1159/000499964DOI Listing
April 2019
2 Reads

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study.

Am J Nephrol 2019 Apr 12;49(5):400-409. Epub 2019 Apr 12.

Central and Northern Adelaide Renal and Transplantation Services (CNARTS), Royal Adelaide Hospital, Adelaide, South Australia, Australia,

Background And Objectives: Kidney disorders in pregnancy may be under-recognized and have variable impact on outcomes depending on diagnosis. Population-level data are limited, particularly for Australia, and comparison of impact of different kidney disorders on pregnancy has rarely been assessed. This study examined the prevalence and outcomes of varied kidney disorders using population-level perinatal data from a large cohort. Read More

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http://dx.doi.org/10.1159/000499965DOI Listing
April 2019
1 Read

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Preeclampsia/Eclampsia.

J Obstet Gynecol Neonatal Nurs 2019 Apr 10. Epub 2019 Apr 10.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from preeclampsia/eclampsia by the California Pregnancy-Associated Mortality Review Committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 242 QIOs identified from 54 cases of pregnancy-related deaths from preeclampsia/eclampsia in California between 2002 and 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.02.008DOI Listing
April 2019
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[Clinical practice recommendations for diabetes in pregnancy (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

In 1989 the St. Vincent Declaration aimed to achieve comparable pregnancy outcomes in diabetic and non-diabetic women. However, currently women with pre-gestational diabetes still feature a higher risk of perinatal morbidity and even increased mortality. Read More

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http://dx.doi.org/10.1007/s00508-019-1456-yDOI Listing
April 2019
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Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.

PLoS One 2019 12;14(4):e0215326. Epub 2019 Apr 12.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215326PLOS
April 2019
2 Reads

Development and validation of a clinical model for preconception and early pregnancy risk prediction of gestational diabetes mellitus in nulliparous women.

PLoS One 2019 12;14(4):e0215173. Epub 2019 Apr 12.

Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, United States of America.

Implementation of dietary and lifestyle interventions prior to and early in pregnancy in high risk women has been shown to reduce the risk of gestational diabetes mellitus (GDM) development later in pregnancy. Although numerous risk factors for GDM have been identified, the ability to accurately identify women before or early in pregnancy who could benefit most from these interventions remains limited. As nulliparous women are an under-screened population with risk profiles that differ from their multiparous counterparts, development of a prediction model tailored to nulliparous women may facilitate timely preventive intervention and improve maternal and infant outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215173PLOS
April 2019
1 Read
3.234 Impact Factor

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.

Hypertens Pregnancy 2019 Apr 12:1-8. Epub 2019 Apr 12.

c Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Steele Center for Translational Medicine , University of Utah , Salt Lake City , USA.

Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD).

Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Read More

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http://dx.doi.org/10.1080/10641955.2019.1597107DOI Listing
April 2019
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An evaluation of whether a gestational weight gain of 5 to 9 kg for obese women optimizes maternal and neonatal health risks.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):126. Epub 2019 Apr 11.

College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, 77843-4475, USA.

Background: Maternal obesity has a wide range of health effects on both the pregnant woman and developing fetus. The clinical significance of these disorders, combined with a dramatically increasing prevalence of obesity among pregnant women has precipitated a major health crisis in the United States. The most commonly used recommendations for gestational weight gain were established by the Institute of Medicine (IOM) in 2009 and have become well known and often adopted. Read More

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http://dx.doi.org/10.1186/s12884-019-2273-zDOI Listing
April 2019
1 Read

Peripartum outcomes in a large population of women with pulmonary arterial hypertension associated with congenital heart disease.

Eur J Prev Cardiol 2019 Apr 11:2047487318821246. Epub 2019 Apr 11.

1 Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University, China.

Aims: Pulmonary arterial hypertension is a severe complication in patients with congenital heart disease and poses a significant risk to women wishing to become pregnant. This study describes the clinical presentation, maternal outcomes and risk factors for the peripartum period in women with pulmonary arterial hypertension related to congenital heart disease (PAH-CHD).

Methods: All pregnant women with PAH-CHD who were admitted for delivery in a tertiary center between February 2011-September 2016 were included. Read More

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http://dx.doi.org/10.1177/2047487318821246DOI Listing
April 2019
3 Reads

Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Braz J Med Biol Res 2019 Apr 8;52(4):e7546. Epub 2019 Apr 8.

Department of Gynecology and Obstetrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Read More

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http://dx.doi.org/10.1590/1414-431X20197546DOI Listing
April 2019
1 Read

Maternal diabetes and hypertensive disorders in association with autism spectrum disorder.

Autism Res 2019 Apr 10. Epub 2019 Apr 10.

The University of North Carolina, Chapel Hill, North Carolina.

Previous studies have shown complications of pregnancy, often examined in aggregate, to be associated with autism spectrum disorder (ASD). Results for specific complications, such as maternal diabetes and hypertension, have not been uniformly consistent and should be investigated independently in relation to ASD in a large community-based sample. The Study to Explore Early Development (SEED), a US multisite case-control study, enrolled children born in 2003-2006 at 2-5 years of age. Read More

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http://dx.doi.org/10.1002/aur.2105DOI Listing
April 2019
1 Read

In utero sFlt-1 exposure differentially affects gene expression patterns in fetal liver.

J Dev Orig Health Dis 2019 Apr 10:1-9. Epub 2019 Apr 10.

1Department of Obstetrics and Gynecology,University of Groningen,University Medical Center Groningen,The Netherlands.

The soluble fms-like tyrosine kinase factor 1 (sFlt-1) is a major contributor to antiangiogenesis during preeclampsia. However, little is known about the effects of sFlt-1 on fetal health. In this study we aim to evaluate the effects of the sFlt-1 concentration during pregnancy on fetal liver physiology. Read More

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http://dx.doi.org/10.1017/S2040174418000831DOI Listing
April 2019
2 Reads

Preeclampsia link to gestational hypoxia.

Authors:
W Tong D A Giussani

J Dev Orig Health Dis 2019 Apr 10:1-12. Epub 2019 Apr 10.

1Department of Physiology Development & Neuroscience,University of Cambridge,Cambridge,UK.

Complications of pregnancy remain key drivers of morbidity and mortality, affecting the health of both the mother and her offspring in the short and long term. There is lack of detailed understanding of the pathways involved in the pathology and pathogenesis of compromised pregnancy, as well as a shortfall of effective prognostic, diagnostic and treatment options. In many complications of pregnancy, such as in preeclampsia, there is an increase in uteroplacental vascular resistance. Read More

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http://dx.doi.org/10.1017/S204017441900014XDOI Listing
April 2019
1 Read

Maternal anemia and pregnancy outcomes: a population-based study.

J Perinatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Objective: This study aims to describe adverse maternal and neonatal outcomes in women diagnosed with anemia in pregnancy.

Study Design: This was a retrospective cohort study of California live births from 2007-2012, linked to maternal and infant hospital discharge records. Relative risks of adverse maternal and neonatal outcomes were calculated for women with and without anemia. Read More

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http://dx.doi.org/10.1038/s41372-019-0375-0DOI Listing
April 2019
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Postpartum Cardiovascular Outcomes Among Women With Heart Disease from A Nationwide Study.

Am J Cardiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Medicine, Division of Cardiovascular Medicine, State University of New York, Stony Brook University Medical Center, Stony Brook, New York. Electronic address:

There is limited data on postpartum maternal postpartum major adverse cardiovascular and cerebrovascular events (MACCE) among women with heart disease (HD) in the US. Therefore, we aimed to determine the prevalence and predictors of MACCE in the US. The Nationwide Readmissions Databases (2010 to 2014) were screened for patients with and without HD undergoing delivery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193030
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http://dx.doi.org/10.1016/j.amjcard.2019.03.012DOI Listing
March 2019
3 Reads

Delayed Initiation of Hemodialysis in Pregnant Women with Chronic Kidney Disease: Logistical Problems Impact Clinical Outcomes. An Experience from an Emerging Country.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Unidad de Investigación Médica en Enfermedades Nefrológicas, CMN Siglo XXI, 06720 CdMx, México.

Background: Chronic kidney disease (CKD) is associated with reduction of fertility and increased complications during pregnancy. The aim of this work is to analyze the clinical outcomes and risk factors in pregnant women who needed to start dialysis with different schedules in a public hospital in Mexico City, with particular attention on the interference of social and cultural elements as well as resource limitations.

Material And Methods: CKD women who needed dialysis in pregnancy over the period 2002⁻2014 and had with complete demographic and outcome data were included in this retrospective study. Read More

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http://dx.doi.org/10.3390/jcm8040475DOI Listing

Deep targeted sequencing reveals the diversity of TRB-CDR3 repertoire in patients with preeclampsia.

Hum Immunol 2019 Apr 6. Epub 2019 Apr 6.

Department of Genetics, National Research Institute for Family Planning, Beijing, 100081, China; Graduate School of Peking Union Medical College, Beijing, 100730, China. Electronic address:

Preeclampsia (PE) is one of the major causes of maternal and perinatal mortality worldwide. This study aimed to determine the immunological characteristics of PE patients and normal pregnancy at the T cell receptor beta-chain (TRB) level by using high-throughput sequencing. High-throughput sequencing was performed to analyze the expression of TRB-CDR3 in circulating T cells. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.04.003DOI Listing
April 2019
1 Read

Clinical and Molecular Perspectives of Monogenic Hypertension.

Curr Hypertens Rev 2019 Apr 9. Epub 2019 Apr 9.

Department of Physiology, Wayne State University School of Medicine and the John D. Dingell VA Medical Center, Detroit, Michigan, MI. United States.

Advances in molecular research techniques have enabled a new frontier in discerning the mechanisms responsible for monogenic diseases. In this review, we discuss the current research on the molecular pathways governing blood pressure disorders with a Mendelian inheritance pattern, each presenting with a unique pathophysiology. Glucocorticoid remediable aldosteronism (GRA) and apparent mineralocorticoid excess (AME) are caused by mutations in regulatory enzymes that induce increased production of mineralocorticoids or inhibit degradation of glucocorticoids, respectively. Read More

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http://dx.doi.org/10.2174/1573402115666190409115330DOI Listing
April 2019
1 Read

Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats.

Physiol Rep 2019 Apr;7(7):e14038

Department of Experimental Therapeutics and Pharmacologyogy, University of Mississippi Medical Center, Jackson, Mississippi.

Previous studies by our lab have established that placental-ischemia stimulated T-helper 17 cells (T 17s) cause increased cytolytic natural killer (cNK) cell proliferation and activation during pregnancy; however, the exact mechanism is unknown. The objective of this study was to investigate the role of interlukin 17 (IL-17) in inducing cNK cell activation in pregnancy. We infused 150 pg/day of recombinant IL-17 into a subset of normal pregnant (NP) Sprague Dawley rats from gestation day (GD) 12-19 (NP+IL-17). Read More

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http://dx.doi.org/10.14814/phy2.14038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453821PMC
April 2019
1 Read

The association between high-normal blood pressure and the development of preeclampsia in twin pregnancies.

J Matern Fetal Neonatal Med 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Department of Obstetrics , Gynecology, and Reproductive Sciences, Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Objective: We sought to determine if women with twin pregnancies and blood pressure (BP) above the 95th percentile but within normal ranges (i.e. less than 140 systolic and 90 diastolic) are at increased risk of hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601696DOI Listing
April 2019
1 Read

An Analysis of Cause of Stillbirth in a Tertiary Care Hospital of Delhi: A Contribution to the WHO SEARO Project.

J Obstet Gynaecol India 2019 Apr 10;69(2):155-160. Epub 2018 Aug 10.

Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Shahid Bhagat Singh Marg, New Delhi, 110001 India.

Background: Over 98% of the world's total stillbirths are believed to occur in developing countries and still have received very little research, programmatic or policy attention.

Aims And Objective: To collect data on epidemiological profile of cases experiencing stillbirths, to assess the associated antenatal high risk factors present and to find out the probable cause of stillbirth.

Materials And Methods: This was a cross-sectional, observational study, which was done as part of WHO SEARO project after ethical clearance. Read More

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http://dx.doi.org/10.1007/s13224-018-1161-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430444PMC
April 2019
3 Reads

Role of proteases in dysfunctional placental vascular remodelling in preeclampsia.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 4. Epub 2019 Apr 4.

Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, 4029, Queensland, Australia; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile. Electronic address:

Preeclampsia is a syndrome characterised by vascular dysfunction, impaired angiogenesis, and hypertension during pregnancy. Even when the precise pathophysiology of preeclampsia remains elusive, impaired vascular remodelling and placental angiogenesis in the placental villi and defective trophoblast invasion of the uterus are proposed as crucial mechanisms in this syndrome. Reduced trophoblast invasion leads to reduced uteroplacental blood flow and oxygen availability and increased oxidative stress. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.04.004DOI Listing
April 2019
3 Reads

Calprotectin in pregnancy and pregnancy-associated diseases: a systematic review and prospective cohort study.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology, Ruhr-Universität Bochum - Marien Hospital Herne, Hölkeskampring 40, 44625, Herne, Germany.

Purpose: Calprotectin, a marker of acute and chronic inflammation, may play a role in pregnancy-associated disorders. We aimed to summarize available clinical data on calprotectin in pregnancy and to establish normal values of calprotectin during the course of pregnancy.

Methods: We performed a systematic review of the databases PubMed and Cochrane Central Register of Controlled Trials to identify experimental and clinical evidence assessing the role of calprotectin in pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-019-05134-8DOI Listing
April 2019
2 Reads

Incremental prognostic value of global left atrial peak strain in women with new-onset gestational hypertension.

J Hypertens 2019 Apr 3. Epub 2019 Apr 3.

Cardiovascular Department, MultiMedica IRCCS, Milan, Italy.

Background: Left atrial strain and strain rate parameters, measured by bidimensional-speckle tracking echocardiography, have been proposed as predictors of atrial fibrillation, stroke, congestive heart failure and cardiovascular death. However, they have not yet been tested in hypertensive disorders of pregnancy. The aim of this study was to assess the prognostic role of global left atrial peak strain (GLAPS) in a population of pregnant women with new-onset hypertension in a medium-term follow-up. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002086DOI Listing
April 2019
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I-ACT: Integrated study on effect of Activity on ComplicaTions in pregnancy: study protocol of a multiethnic prospective cohort study.

BMJ Open 2019 Apr 3;9(4):e025970. Epub 2019 Apr 3.

Family Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: Physical activity (PA) during first 20 weeks of pregnancy may lower risks of gestational diabetes mellitus (GDM) and gestational hypertension (GH), though evidence of association remains inconclusive. Current studies rely heavily on subjective assessment of PA levels. Wearable activity trackers provide a convenient and objective surrogate index for PA validated by evidence-based steps/day categorisation along a physical inactivity/activity continuum. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025970DOI Listing
April 2019
4 Reads

Advanced Maternal Age: Adverse Outcomes of Pregnancy, A Meta-Analysis.

Acta Med Port 2019 Mar 29;32(3):219-226. Epub 2019 Mar 29.

Documentation Service. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

Introduction: The risks of pregnancy in women of advanced maternal age are not consensual amongst studies. The aim of this metaanalysis  was to determine whether women of advanced maternal age (≥ 35 years old) had worse obstetrical and perinatal outcomes than non- advanced maternal age women (20 - 34 years old) in singleton, naturally-conceived pregnancies.

Material And Methods: We searched PubMed/ MEDLINE, IndexRMP and the Cochrane Database of Systematic Reviews. Read More

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http://dx.doi.org/10.20344/amp.11057DOI Listing
March 2019
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Immune imbalance is associated with the development of preeclampsia.

Medicine (Baltimore) 2019 Apr;98(14):e15080

State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Preeclampsia (PE) is characterized by hypertension and proteinuria. It affects about 5% to 8% of pregnancies and causes maternal and perinatal mortality and morbidity. The immune imbalance and excessive inflammatory response play vital roles in the pathogenesis of PE. Read More

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http://dx.doi.org/10.1097/MD.0000000000015080DOI Listing
April 2019
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A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report.

BMC Pregnancy Childbirth 2019 Apr 3;19(1):116. Epub 2019 Apr 3.

Department of cardiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12884-019-2262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448298PMC
April 2019
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Pharmacotherapy for hypertension in pregnant patients: special considerations.

Expert Opin Pharmacother 2019 Apr 3:1-20. Epub 2019 Apr 3.

a Department of Pharmacology and Toxicology, School of Medicine , Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV , Madrid , Spain.

Introduction: Hypertensive disorders of pregnancy (HDP) represent a major cause of maternal, fetal and neonatal morbidity and mortality and identifies women at risk for cardiovascular and other chronic diseases later in life. When antihypertensive drugs are used during pregnancy, their benefit and harm to both mother and fetus should be evaluated. Areas covered: This review summarizes the pharmacological characteristics of the recommended antihypertensive drugs and their impact on mother and fetus when administered during pregnancy and/or post-partum. Read More

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http://dx.doi.org/10.1080/14656566.2019.1594773DOI Listing
April 2019
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The efficacy of the Dietary Approaches to Stop Hypertension diet with respect to improving pregnancy outcomes in women with hypertensive disorders.

J Hum Nutr Diet 2019 Apr 3. Epub 2019 Apr 3.

Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Background: The DASH (Dietary Approaches to Stop Hypertension) diet serves as a dietary pattern for the prevention and control of hypertension. The present study aimed to investigate whether the DASH diet can improve the outcomes of pregnancy with gestational hypertension (GH) and chronic hypertension.

Methods: The current randomised controlled clinical trial was performed in 85 pregnant women diagnosed with GH and chronic hypertension between July 2015 and December 2017. Read More

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http://dx.doi.org/10.1111/jhn.12654DOI Listing
April 2019
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Gestational Weight Gain among Healthy Pregnant Women from Asia in Comparison with Institute of Medicine (IOM) Guidelines-2009: A Systematic Review.

J Pregnancy 2019 3;2019:3849596. Epub 2019 Mar 3.

Department of Food and Nutrition, Institute of Home Economics, Delhi University, F-4, Hauz Khas Enclave, New Delhi, India.

In 1990, Institute of Medicine (IOM) recommended gestational weight gain (GWG) ranges for women in the United States primarily to improve infant birth weight. Changes in key aspects of reproductive health of women of child bearing age, a rising prevalence of obesity, and noncommunicable diseases prompted the revision of IOM guidelines in 2009. However, there is no such recommendation available for Asian women. Read More

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http://dx.doi.org/10.1155/2019/3849596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421048PMC
March 2019
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Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long-term postpartum?

Am J Obstet Gynecol 2019 Mar 30. Epub 2019 Mar 30.

Erasmus MC, University Medical Center Rotterdam, the Netherlands, Department of Obstetrics and Gynecology.

Background: An atherogenic lipid profile is a risk factor for the initiation and progression of atherosclerosis. This ultimately leads to cardiovascular disease. Women with a history of hypertensive disorders of pregnancy are at increased risk of sustained hypertension and cardiovascular disease later in life. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.025DOI Listing
March 2019
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Neonatal developmental and behavioral outcomes of immediate delivery versus expectant monitoring in mild hypertensive disorders of pregnancy: 2-year outcomes of the HYPITAT II trial.

Am J Obstet Gynecol 2019 Mar 30. Epub 2019 Mar 30.

Epidemiology, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Management of preterm hypertensive disorders remains a clinical dilemma. The maternal benefits of delivery need to be weighed against the adverse neonatal consequences of preterm birth. Long-term consequences of obstetric management in offspring of women with hypertensive disorders in preterm pregnancy are largely unknown. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.024DOI Listing
March 2019
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Hypertensive Disorders of Pregnancy.

Emerg Med Clin North Am 2019 May;37(2):301-316

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, Suite 200; 6th Floor, Baltimore, MD 21201, USA; Department of Internal Medicine, University of Maryland School of Medicine, 110 South Paca Street, Suite 200; 6th Floor, Baltimore, MD 21201, USA.

The 4 categories of hypertensive disorders of pregnancy are chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia. These disorders are among the leading causes of maternal and fetal morbidity and mortality. Proper diagnosis in the emergency department is crucial in order to initiate appropriate treatment to reduce the potential harm to the mother and the fetus. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.008DOI Listing
May 2019
2 Reads

Correlation of miR-21 and BNP with pregnancy-induced hypertension complicated with heart failure and the diagnostic value.

Exp Ther Med 2019 Apr 19;17(4):3129-3135. Epub 2019 Feb 19.

Department of Obstetrics, Yanan Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650051, P.R. China.

Correlation of miR-21 and B-type natriuretic peptide (BNP) with pregnancy-induced hypertension (PIH) complicated with heart failure and the diagnostic value was investigated. Sixty patients with PIH complicated with heart failure admitted to Affiliated Hospital of Chengde Medical University from July 2016 to July 2017 were enrolled as the experimental group, and 35 normal pregnant women as the control group. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) method was used to determine the expression level of plasma miR-21 expression level. Read More

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http://dx.doi.org/10.3892/etm.2019.7286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434261PMC
April 2019
2 Reads