29,251 results match your criteria Hypertension and Pregnancy


Receipt of Proton-Pump Inhibitors during Pregnancy and Risk for Preeclampsia.

Am J Perinatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York.

Objective:  This study aimed to determine whether receiving a proton-pump inhibitor (PPI) prescription during pregnancy was associated with decreased risk for preeclampsia.

Study Design:  The Truven Health MarketScan database was used to determine whether receiving a PPI prescription was associated with risk for preeclampsia. Risk for preeclampsia was evaluated based on the presence or absence of receiving a PPI prescription (1) any time during pregnancy, and 2) individually during the 1st, 2nd, and 3rd trimesters. Read More

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http://dx.doi.org/10.1055/s-0040-1713864DOI Listing

Placental Extracellular Vesicles and Preeclampsia.

Am J Reprod Immunol 2020 Jul 3:e13297. Epub 2020 Jul 3.

Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA.

Preeclampsia is a hypertensive disease of pregnancy characterized by new-onset hypertension, with either proteinuria and/or organ dysfunction. Preeclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in preeclampsia is centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of preeclampsia. Read More

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http://dx.doi.org/10.1111/aji.13297DOI Listing

Techniques for preventing hypotension during spinal anaesthesia for caesarean section.

Cochrane Database Syst Rev 2020 Jul 1;7:CD002251. Epub 2020 Jul 1.

Department of Women's Anaesthesia, Women's and Children's Hospital, Adelaide, Australia.

Background: Maternal hypotension is the most frequent complication of spinal anaesthesia for caesarean section. It can be associated with nausea or vomiting and may pose serious risks to the mother (unconsciousness, pulmonary aspiration) and baby (hypoxia, acidosis, neurological injury).

Objectives: To assess the effects of prophylactic interventions for hypotension following spinal anaesthesia for caesarean section. Read More

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http://dx.doi.org/10.1002/14651858.CD002251.pub4DOI Listing

Administration of recombinant human placental growth factor decreases blood pressure in obese hypertensive pregnant rats.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgery, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi.

Objectives: Although epidemiological studies have shown that obesity is associated with increased incidence of hypertension during pregnancy, the mechanisms linking these two comorbidities are not as well studied. Previous investigations detected lower levels of the anti-hypertensive and pregnancy-related factor, placental growth factor (PlGF), in obese hypertensive pregnancies. Therefore, we examined whether obese hypertensive pregnant rats have reduced PlGF and whether increasing its levels by administering recombinant human (rh)PlGF reduces their blood pressure. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002528DOI Listing

High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.

Objective: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002497DOI Listing

Effects of sleep modulation during pregnancy in the mother and offspring: Evidences from preclinical research.

J Sleep Res 2020 Jul 2:e13135. Epub 2020 Jul 2.

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Disturbed sleep during gestation may lead to adverse outcomes for both mother and child. Animal research plays an important role in providing insights into this research field by enabling ethical and methodological requirements that are not possible in humans. Here, we present an overview and discuss the main research findings related to the effects of prenatal sleep deprivation in animal models. Read More

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http://dx.doi.org/10.1111/jsr.13135DOI Listing

Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment.

J Clin Endocrinol Metab 2020 Jul 3. Epub 2020 Jul 3.

The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK.

Context: Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.

Objective: To investigate the diagnostic and therapeutic potential of the angiogenesis markers, FKBPL-CD44, in preeclampsia pathogenesis.

Design And Intervention: FKBPL and CD44 plasma or placental concentration was determined in women pre- or post-diagnosis of preeclampsia. Read More

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http://dx.doi.org/10.1210/clinem/dgaa403DOI Listing

Lifetime Psychosocial Stress Exposure Associated with Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, NorthShore University Health System, Center for Healthcare Studies, Institute for Public Health and Medicine, University of Chicago Pritzker School of Medicine, Northwestern University, Evanston, Illinois.

Objective:  Hypertensive disorders of pregnancy (HDP) complicate 5 to 10% of all pregnancies and are a major cause of pregnancy-related morbidity. Exposure to psychosocial stress has been associated with systemic inflammation and adverse birth outcomes in pregnant women. Thus, it is probable that psychosocial stress and inflammation play a role in the development of HDP. Read More

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http://dx.doi.org/10.1055/s-0040-1713368DOI Listing

High-risk third trimester pregnancy with decompensated cirrhosis safely delivered following emergent preoperative interventional radiology for mitigation of variceal bleeding.

Clin Imaging 2020 Jun 18;68:143-147. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Coagulopathy coupled with severe portal hypertension in the setting of cirrhosis increases the risk of mortality from variceal bleeding in pregnant women. Studies suggest transjugular intrahepatic portosystemic shunt (TIPS) creation to be a safe procedure during pregnancy in preventing variceal bleeding complications; however, it is not typically employed in severely decompensated cirrhosis. This case report of a pregnant woman presenting at 34. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.032DOI Listing

Benefit of standardized risk assessment for postpartum hemorrhage.

Authors:
Stephen Contag

BJOG 2020 Jul 1. Epub 2020 Jul 1.

Department of Obstetrics, Gynecology and Women's Health, University of Minnesota Medical School, MMC 395, 420 Delaware Street, S.E, Minneapolis, Minnesota, 55455, United States.

Global estimates for 2017 indicated that there were 295,000 maternal deaths, 35 per cent lower than in 2000 with a decline in global maternal mortality ratio from 342 to 211 deaths per 100,000 live births (World Health Organization (WHO) 2019). Maternal hemorrhage is the leading direct cause of maternal death worldwide, representing 27% (20-36) of maternal deaths ( Say L, et al. Lancet 2014). Read More

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http://dx.doi.org/10.1111/1471-0528.16390DOI Listing

Granulomatosis with polyangiitis and pregnancy: Anti-neutrophil cytoplasmic antibody, placental inflammation, chorangiosis and pre-eclampsia.

J Obstet Gynaecol Res 2020 Jul 1. Epub 2020 Jul 1.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

Granulomatosis with polyangiitis (GPA) is a rare necrotizing autoimmune disease involving small vessel vasculitis. Pregnancies with GPA have increased rates of obstetric complications including pre-eclampsia. Differential diagnosis of GPA flares up and pre-eclampsia may be difficult and necessitates careful clinical practice. Read More

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http://dx.doi.org/10.1111/jog.14356DOI Listing

Neonatal and Maternal Outcomes among Women with Glomerulonephritis.

Am J Nephrol 2020 Jul 1:1-8. Epub 2020 Jul 1.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Background: The outcomes of pregnancy in women with renal diseases remain controversial. The purpose of the study was to report fetal and maternal outcomes among women with glomerular disease in comparison with healthy pregnant women and a review of the current literature on this issue.

Methods: Retrospective analysis included 72 pregnancies in 62 women with biopsy-proven glomerulonephritis (GN) (in 65. Read More

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http://dx.doi.org/10.1159/000508600DOI Listing

Comparison of the resistive indices obtained in the uterine artery and the ophthalmic artery in preeclamptic and normotensive patients in Doppler US.

J Ultrason 2020 15;20(81):e95-e99. Epub 2020 Jun 15.

University Institute of Radiological Sciences and Medical Imaging Technologies (UIRSMIT), Faculty of Allied Health Sciences (FAHS), University of Lahore , Lahaur , Pakistan.

Preeclampsia is a medical condition characterized by hypertension and proteinuria during pregnancy, with the symptoms generally manifesting in the 3 trimester. Hypertension brings hemodynamic changes; it is therefore expected that arterial blood flow velocity waveforms will be different in the uterine and ophthalmic arteries in preeclampsia. Vascular changes do occur in preeclampsia, which in turn induces hemodynamic changes. Read More

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http://dx.doi.org/10.15557/JoU.2020.0015DOI Listing

Changes of plasma Von Willebrand factor and Von Willebrand factor-cleaving protease levels in pregnancy-induced hypertension.

J Biol Regul Homeost Agents 2020 Jun 30;34(3). Epub 2020 Jun 30.

Department of Obstetrics, The First Hospital of Jilin University, Changchun City, China.

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http://dx.doi.org/10.23812/19-514-L-51DOI Listing

Birth anthropometry and cord blood leptin in Korean appropriate-for-gestational-age infants born at ≥ 28 weeks' gestation: a cross sectional study.

Int J Pediatr Endocrinol 2020 26;2020:12. Epub 2020 Jun 26.

Department of Pediatrics, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea.

Background: We investigated whether leptin during the third trimester was associated with fetal growth compared to IGF-1.

Methods: One hundred five appropriate-for-gestational-age (AGA) infants born at ≥28 weeks' gestation were enrolled. Cord blood leptin and insulin like growth factor 1 (IGF-1) were collected simultaneously during delivery. Read More

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http://dx.doi.org/10.1186/s13633-020-00082-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318406PMC

Vitiligo and Rise in Blood Pressure - a Case-Control Study in a Referral Dermatology Clinic in Southern Iran.

Clin Cosmet Investig Dermatol 2020 22;13:425-430. Epub 2020 Jun 22.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Vitiligo is an acquired hypopigmentation condition in which well-defined macules can develop virtually everywhere on the patients' skin. This analytic case-control study was conducted in Faghihi Hospital outpatient dermatology clinic, affiliated to Shiraz University of Medical Sciences, southern Iran from June to September 2019. Furthermore, we studied the relationship of hypertension with activity, age of onset, duration, affected body surface area and type of vitiligo. Read More

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http://dx.doi.org/10.2147/CCID.S257022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319509PMC

No evidence of vertical transmission of SARS-CoV-2 after induction of labour in an immune-suppressed SARS-CoV-2-positive patient.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, Zuid-Holland, The Netherlands

We present a case of a 38+1 weeks pregnant patient (G1P0) with a proven COVID-19 infection, who was planned for induction of labour because of pre-existent hypertension, systemic lupus erythematosus, respiratory problem of coughing and mild dyspnoea without fever during the COVID-19 pandemic in March 2020. To estimate the risk of vertical transmission of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) during labour and delivery, we collected oropharyngeal, vaginal, urinary, placental and neonatal PCRs for SARS-CoV-2 during the period of admission. All PCRs, except for the oropharyngeal, were negative and vertical transmission was not observed. Read More

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http://dx.doi.org/10.1136/bcr-2020-235581DOI Listing

Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Hypertension and chronic kidney disease (CKD) can originate during early-life. Tryptophan metabolites generated by different pathways have both detrimental and beneficial effects. In CKD, uremic toxins from the tryptophan-generating metabolites are endogenous ligands of the aryl hydrocarbon receptor (AHR). Read More

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http://dx.doi.org/10.3390/ijms21124552DOI Listing

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus-One of Several Possible Reasons for an Increased Cardiovascular Risk.

Cells 2020 Jun 26;9(6). Epub 2020 Jun 26.

Institute for the Care of the Mother and Child, Third Faculty of Medicine, Charles University, 14700 Prague, Czech Republic.

Gestational diabetes mellitus (GDM), one of the major pregnancy-related complications, characterized as a transitory form of diabetes induced by insulin resistance accompanied by a low/absent pancreatic beta-cell compensatory adaptation to the increased insulin demand, causes the acute, long-term, and transgenerational health complications. The aim of the study was to assess if alterations in gene expression of microRNAs associated with diabetes/cardiovascular/cerebrovascular diseases are present in whole peripheral blood of children aged 3-11 years descending from GDM complicated pregnancies. A substantially altered microRNA expression profile was found in children descending from GDM complicated pregnancies. Read More

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http://dx.doi.org/10.3390/cells9061557DOI Listing

[Unsolved issues of pregnancy in liver cirrhosis].

Ter Arkh 2019 Apr 15;91(4):114-117. Epub 2019 Apr 15.

Obstetric Clinic, University Hospital "Dr. Georgi Stranski", Department of obstetrics and gynecology, Medical University.

Pregnancy in patients with liver cirrhosis and portal hypertension occurs very rare, because of their significantly derailed reproductive functions. Тhe risks for the mother and the fetus are connected with worsening of the portal hypertension, progression of decompensated liver cirrhosis and development of its complications: liver failure, ascites, hepatorenal syndrome, hepatic encephalopathy and variceal hemorrhage, and with increased incidence of spontaneous abortions and abnormal uterine bleeding. The decision for continuation of the pregnancy in cirrhotic patients must be based on individual approach and a multidisciplinary team consisting of obstetricians, hepatologists, anesthesiologists, surgeons and hematologists must participate in the therapy. Read More

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http://dx.doi.org/10.26442/00403660.2019.04.000145DOI Listing

Preconception Evaluation Before In Vitro Fertilization.

Obstet Gynecol Surv 2020 Jun;75(6):359-368

Assistant Professor, Division of Reproductive Endocrinology, Duke Department of Obstetrics and Gynecology, Durham, NC.

Importance: Infertility poses a substantial public health problem for women of reproductive age, in the United States and globally. Infertility can be overcome with a variety of emerging assisted reproductive technologies (ARTs). In vitro fertilization (IVF) currently represents the most commonly utilized method of ART and is typically associated with the highest clinical pregnancy rate and live birth rate compared with other infertility treatment options. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000788DOI Listing

Cyclosporin in Dermatology: A Practical Compendium.

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

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http://dx.doi.org/10.1111/dth.13934DOI Listing

Prediction of adverse cardiac events in pregnant women with valvular rheumatic heart disease.

Heart 2020 Jun 29. Epub 2020 Jun 29.

Anaesthesiology & Critical Care, Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: To assess the incidence of adverse cardiac events in pregnant women with rheumatic valvular heart disease (RHD) and to derive a clinical risk scoring for predicting it.

Methods: This is an observational study involving pregnant women with RHD, attending a tertiary centre in south India. Data regarding obstetric history, medical history, maternal complications and perinatal outcome till discharge were collected. Read More

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http://dx.doi.org/10.1136/heartjnl-2020-316648DOI Listing

Unfractionated heparin displaces sFlt-1 from the placental extracellular matrix.

Biol Sex Differ 2020 Jun 29;11(1):34. Epub 2020 Jun 29.

Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA.

Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is an anti-angiogenic protein which is secreted by numerous cell types and acts as a decoy receptor for the angiogenic protein vascular endothelial growth factor (VEGF). Despite its physiologic importance in maintaining angiogenic balance, excess sFlt-1 levels are associated with the pathogenesis of many diseases, especially those with angiogenic imbalance, endothelial dysfunction, and hypertension. Although sFlt-1 is a soluble protein, it contains a binding site for the extracellular matrix component heparan sulfate. Read More

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http://dx.doi.org/10.1186/s13293-020-00311-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325113PMC

Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta.

Biomolecules 2020 Jun 24;10(6). Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, UMKC School of Medicine, Kansas City, MO 64108, USA.

Preeclampsia (PE) is a serious pregnancy complication, affecting about 5-7% of pregnancies worldwide and is characterized by hypertension and damage to multiple maternal organs, primarily the liver and kidneys. PE usually begins after 20 weeks' gestation and, if left untreated, can lead to serious complications and lifelong disabilities-even death-in both the mother and the infant. As delivery is the only cure for the disease, treatment is primarily focused on the management of blood pressure and other clinical symptoms. Read More

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http://dx.doi.org/10.3390/biom10060953DOI Listing

Pre-Pregnancy Obesity, Excessive Gestational Weight Gain, and the Risk of Pregnancy-Induced Hypertension and Gestational Diabetes Mellitus.

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

Division of Gynecological Surgery, University Hospital, 33 Polna Str., Poznan University of Medical Sciences, 60-535 Poznan, Poland.

Excessive pre-pregnancy weight is a known risk factor of pregnancy complications. The purpose of this analysis was to assess the relationship between several categories of maternal weight and the risk of developing hypertension and diabetes in pregnancy, and the relationship of these complications with the results of the newborn. It was carried out in a common cohort of pregnant women and taking into account the influence of disturbing factors. Read More

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http://dx.doi.org/10.3390/jcm9061980DOI Listing

Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women.

J Clin Pharmacol 2020 Jun 29. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

Response to acute treatment of severe hypertension during pregnancy in Asian women was not known. Labor and delivery checklists of Thai women treated with intravenous hydralazine or labetalol for systolic blood pressure (SBP) ≥ 160 or diastolic blood pressure (DBP) ≥ 110 mm Hg from January 2011 to December 2013 were reviewed as parts of an audit. Primary outcome was prompt achievement of SBP 140-150 and DBP 90-100 mm Hg after the first bolus. Read More

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http://dx.doi.org/10.1002/jcph.1685DOI Listing

Review article: chronic liver disease and pregnancy.

Aliment Pharmacol Ther 2020 Jun 29. Epub 2020 Jun 29.

Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

Background: The prevalence of chronic liver disease in women of child bearing age is increasing, leading to a higher incidence of pregnancy in this cohort. Chronic medical conditions have a significant adverse effect on maternal morbidity and mortality. To date, reviews on this topic have been written either from a hepatology or obstetrics viewpoint, and no specific guidelines are available solely for the management of chronic liver disease in pregnancy. Read More

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http://dx.doi.org/10.1111/apt.15908DOI Listing

Clinical characteristics of preeclampsia in twin versus singleton pregnancies.

J Matern Fetal Neonatal Med 2020 Jun 29:1-5. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Lis Maternity and Women's Hospital, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

We aimed to compare features of preeclampsia between twin and singleton pregnancies. In this retrospective case-control study, women with twin pregnancies who were diagnosed with preeclampsia were matched to singleton pregnancies controls. Ninety-four women with twin gestation diagnosed with preeclampsia were compared to singleton pregnancies with preeclampsia. Read More

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http://dx.doi.org/10.1080/14767058.2020.1784872DOI Listing

The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants.

J Epidemiol 2020 Jun 27. Epub 2020 Jun 27.

Center for Genome Science, Korea National Institute of Health.

Background: The Korean Pregnancy Outcome Study (KPOS) was established to investigate the determinants of adverse pregnancy outcomes among Korean women.

Methods: We recruited 4,537 pregnant women between 2013 and 2017 from two tertiary centers located in Seoul, Korea, and a total of 4,195 Korean women met inclusion criteria in the baseline analysis. A range of data on socio-demographics, past medical histories, reproductive information, health-related behaviors, psychological health and clinical information were obtained using interviewer-based questionnaires and clinical assessment at 12, 24, and 36 gestational weeks (GW), delivery and 6-8 weeks postpartum. Read More

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http://dx.doi.org/10.2188/jea.JE20200055DOI Listing

Modeling Pathways From the Perinatal Factors to the Vascular Risk Phenotype at the End of the Second Decade of Life: Birth Cohort, Brazil.

Hypertension 2020 Jun 29:HYPERTENSIONAHA11914218. Epub 2020 Jun 29.

From the Public Health Department, Federal University of Maranhão, São Luís, Brazil (M.S.A., C.C.C.R., M.T.S.d.B.e.A., J.X.P.T.N., V.M.F.S., A.A.M.d.S.).

Risk factors act around birth increasing future vascular risk. In this study, we analysed the pathways from perinatal factors to the vascular risk phenotype (VRP) in adolescents including indirect pathways mediated by obesity in adolescence. Data from a Brazilian cohort were collected at birth and at 18 to 19 years (follow-up). Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14218DOI Listing

ASPIRIN FOR THE PREVENTION OF PLACENTA-MEDIATED COMPLICATIONS IN PREGNANT WOMEN WITH CHRONIC HYPERTENSION.

J Gynecol Obstet Hum Reprod 2020 Jun 25:101845. Epub 2020 Jun 25.

University Paris Est Créteil and CHI Créteil, Créteil, France; Department of Obstetrics Gynecology and Reproductive Medicine, University Paris Est Créteil, Centre Hospitalier Inter-Communal de Créteil, France. Electronic address:

Chronic hypertension affects 1 to 5% of women of childbearing age. During pregnancy, chronic hypertension is associated with an increased risk of vascular disease such as superimposed preeclampsia (PE), intrauterine growth retardation (IUGR), placental abruption, and preterm delivery. These serious and frequent pathologies, specific to pregnancy, carry a particularly high risk of maternal complications (HELLP syndrome, eclampsia, maternal death) and perinatal complications (perinatal death, neurological disorders). Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101845DOI Listing

Added prognostic value of longitudinal changes of angiogenic factors in early-onset severe preeclampsia: a prospective cohort study.

BJOG 2020 Jun 27. Epub 2020 Jun 27.

BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Neonatologia Fetal i+D Fetal Medicine Research Center, Obstetrícia, Barcelona, Spain.

Objective: To assess in women with early-onset severe preeclampsia whether longitudinal changes in angiogenic factors improve the prediction of adverse outcome.

Design: Prospective cohort study.

Setting: Maternity units in two Spanish hospitals. Read More

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http://dx.doi.org/10.1111/1471-0528.16383DOI Listing

Cardiovascular problems associated with IVF-therapy.

Authors:
Peter Henriksson

J Intern Med 2020 Jun 26. Epub 2020 Jun 26.

Karolinska Institutet, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden.

We are now in the beginning of the fifth decade of in vitro fertilization (IVF) with more than ten million children born and an annual growth rate of half a million. It was recently found that there is a sevenfold increase in the incidence of pulmonary embolism (PE) during the first trimester of an IVF pregnancy as compared to spontaneous pregnancy. PE is a major cause of maternal mortality and it is thus of outmost importance to understand the pathophysiological mechanism. Read More

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http://dx.doi.org/10.1111/joim.13136DOI Listing

Maternal Chronic Hypertension Elevates the Risk for Long-Term Selected Endocrine and Metabolic Morbidity in the Offspring, Particularly Childhood Obesity.

Child Obes 2020 Jun 24. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Maternal hypertensive disorders during pregnancy are known to be associated with high rates of perinatal complications for both mother and child. We aimed at determining whether maternal chronic hypertension impacts long-term pediatric endocrine and metabolic morbidity. A population-based, retrospective cohort study was performed. Read More

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http://dx.doi.org/10.1089/chi.2019.0304DOI Listing

Maternal-fetal outcome in pregnancies complicated with non-cirrhotic portal hypertension: experience from a Tertiary Centre in South India.

Hepatol Int 2020 Jun 25. Epub 2020 Jun 25.

Department of Obstetrics& Gynaecology, Jawaharlal Institute of Postgraduate Medical Education & Research, Dhanvantri Nagar, Pondicherry, 605006, India.

Objective: To assess the maternal and perinatal outcomes of pregnant women with non-cirrhotic portal hypertension (NCPH).

Methods: This was an observational study done by retrieving the records of pregnant women with non-cirrhotic portal hypertension admitted to a tertiary hospital in South India, over a 9-year study period. Data regarding the clinical course, complications during pregnancy, labor, and delivery details were reviewed. Read More

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http://dx.doi.org/10.1007/s12072-020-10067-5DOI Listing

Treatment of primary hyperaldosteronism.

Med Clin (Barc) 2020 Jun 22. Epub 2020 Jun 22.

Unidad de Neuroendocrinología, Servicio de Endocrinología y Nutrición, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address:

Primary aldosteronism is associated with higher cardiovascular and renal morbidity and mortality than essential hypertension in age- and sex-matched patients with the same degree of blood pressure elevation. Therefore, it is essential to establish a specific treatment to avoid the deleterious effects of aldosterone excess. Although adrenalectomy is generally considered the treatment of choice in cases of primary aldosteronism due to unilateral disease, several aspects and circumstances should be taken into account that may make medical treatment more appropriate. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.04.029DOI Listing

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.

Mol Med Rep 2020 Jun 23. Epub 2020 Jun 23.

Department of Emergency, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, P.R. China.

Preeclampsia (PE) is a complication during pregnancy that is diagnosed by a new onset of hypertension and proteinuria. Although the pathogenesis of PE is not fully understood, a growing body of evidence indicates that oxidative stress and mitochondrial dysfunction might contribute to the progression of PE. Therefore, the aim of the present study was to determine the role of mitophagy in mitochondrial dysfunction and oxidative stress in PE, and to evaluate the role of DNA damage‑regulated autophagy modulator 1 (DRAM1) in the development of PE. Read More

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http://dx.doi.org/10.3892/mmr.2020.11269DOI Listing

Influence of Parental Exposure to Risk Factors in the Occurrence of Oral Clefts.

J Dent (Shiraz) 2020 Jun;21(2):119-126

Dept. of Pediatric Dentistry, Dental School, University of Cuiabá, Cuiabá, Brazil.

Statement Of The Problem: Non-syndromic cleft lip and palate are the most frequent craniofacial abnormalities in humans. The genetic, environmental and behavioral factors involved in this malformation must be clarified in different parts of the globe in the view of implementing preventive measures.

Purpose: To analyze the influence of parental exposure to risk factors on the occurrence of oral clefts. Read More

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http://dx.doi.org/10.30476/DENTJODS.2019.77620.0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280550PMC

MACRONUTRIENTS OF MOTHERS' MILK OF VERY LOW BIRTH WEIGHT INFANTS: ANALYSIS ACCORDING TO GESTATIONAL AGE AND MATERNAL VARIABLES.

Rev Paul Pediatr 2020 22;39:e2019097. Epub 2020 Jun 22.

Instituto Nacional de Saúde da Mulher e da Criança Fernandes Figueira, Rio de Janeiro, RJ, Brazil.

Objective: To analyze the composition of macronutrients present in the milk of mothers of preterm newborn infants (PTNB) - protein, fat, carbohydrate, and calories - by gestational age (GA), chronological age (CA) and maternal variables.

Methods: Longitudinal study that analyzed 215 milk samples from the 51 mothers of PTNB admitted in three Neonatal Intensive Care Units of Rio de Janeiro from May/2013-January/2014. Milk collection was performed by pickup pump, on a fixed day of each week until discharge. Read More

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http://dx.doi.org/10.1590/1984-0462/2021/39/2019097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309577PMC

Future Cardiovascular Disease Risk for Women With Gestational Hypertension: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2020 Jun 24:e013991. Epub 2020 Jun 24.

Homerton College University of Cambridge United Kingdom.

Background Inconsistent findings have been found among studies evaluating the risk of cardiovascular disease for women who have had pregnancies complicated by gestational hypertension (the new onset of high blood pressure without proteinuria during pregnancy). We provide a comprehensive review of studies to quantify the association between gestational hypertension and cardiovascular events in women. Methods and Results We conducted a systematic search of PubMed, Embase, and Web of Science in March 2019 for studies examining the association between gestational hypertension and any cardiovascular event. Read More

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http://dx.doi.org/10.1161/JAHA.119.013991DOI Listing

A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial.

Food Nutr Res 2020 8;64. Epub 2020 Jun 8.

Department of Obstertrics, Liaocheng People Hospital, Liaocheng, Shandong, China.

Background: Pregnancy-induced hypertension (PIH) is a disease characterized by high blood pressure detected after 20 weeks of pregnancy, affecting approximately 10% of pregnant women worldwide. Effective strategies are imperatively needed to prevent and treat PIH.

Methods: Subjects were required to consume 100 g mushroom daily from pre-pregnancy to the 20th week of gestation. Read More

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http://dx.doi.org/10.29219/fnr.v64.4451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286351PMC

Comorbidities, risk factors and maternal/perinatal outcomes in oocyte donation pregnancies.

Reprod Biomed Online 2020 May 15. Epub 2020 May 15.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence Florence, Italy.

Research Question: To evaluate pre-existing comorbidities, obstetric risk factors and adverse obstetric and neonatal outcomes in pregnancies conceived by oocyte donation, compared with naturally conceived pregnancies or by conventional IVF/intracytoplasmic sperm injection (IVF/ICSI).

Design: This retrospective single-centre contemporary cohort study reviewed data from singleton deliveries at the University Hospital of Careggi, Florence, from 2009 to 2017. Maternal and perinatal outcomes were analysed. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.04.020DOI Listing

Real-world in-hospital outcomes and potential predictors of heart failure in primigravid women with heart disease in Southwestern China.

BMC Pregnancy Childbirth 2020 Jun 23;20(1):372. Epub 2020 Jun 23.

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Little is known about the status of maternal, obstetric, and neonatal complications and the potential predictors of developing heart failure (HF) in mothers with underlying heart disease (HD) in Southwestern China.

Methods: The eligible records from the YiduCloud database from December 1, 2010 to December 31, 2019 were screened. The maternal clinical characteristics and the in-hospital outcomes were collected and compared in primigravid women with and without HD. Read More

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http://dx.doi.org/10.1186/s12884-020-03058-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310540PMC

Association of fetal gender and the onset and severity of hypertensive disorders of pregnancy.

J Matern Fetal Neonatal Med 2020 Jun 23:1-6. Epub 2020 Jun 23.

Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

It was reported that fetal gender was associated with gestational-age related incidence of preeclampsia. However, there is no study to date to evaluate the association of fetal gender differences with all hypertensive disorders of pregnancy. The present study aimed to evaluate the association, if any, between fetal gender differences and the disposition to develop hypertensive disorders of pregnancy and the risk of developing severe features. Read More

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http://dx.doi.org/10.1080/14767058.2020.1783654DOI Listing

Competing risks model for prediction of small-for-gestational-age neonates from maternal characteristics and medical history.

Ultrasound Obstet Gynecol 2020 Jun 23. Epub 2020 Jun 23.

Fetal Medicine Research Institute, King's College Hospital, London, UK.

Background: The established method of identifying a group of women at high-risk of delivering SGA neonates, requiring increased surveillance, is use of risk scoring systems based on maternal demographic characteristics and medical history. Although this approach is relatively simple to perform, it does not provide patient-specific risks and has an uncertain performance of predicting SGA. Another approach to predict delivery of SGA neonates is to use logistic regression models that combine maternal factors with first-trimester biomarkers. Read More

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http://dx.doi.org/10.1002/uog.22129DOI Listing

Hypertensive diseases in pregnancy, cardiac structure and function later in life: Insights from the Genetic Epidemiology Network of Arteriopathy (GENOA) study.

Pregnancy Hypertens 2020 May 29;21:184-190. Epub 2020 May 29.

University of Mississippi Medical Center, Division of Cardiology, Department of Medicine, Jackson, MS, United States. Electronic address:

Background: Hypertensive diseases in pregnancy have been associated with altered cardiac structure and function, yet these associations have not been systematically investigated in larger populations including African Americans. We evaluated the relationships between hypertensive diseases in pregnancy with cardiac structure and function later in life in the Genetic Epidemiology Network of Arteriopathy (GENOA) study.

Methods: We investigated 1013 African American women sibships with echocardiographic measurements from the GENOA study (Phase II, 2000-05; Jackson, MS). Read More

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http://dx.doi.org/10.1016/j.preghy.2020.05.010DOI Listing

To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension.

Pregnancy Hypertens 2020 May 29;21:180-183. Epub 2020 May 29.

Department of Radiodiagnosis, PGIMER, Chandigarh, India.

Objective: To study the maternal hemodynamic changes in acute severe hypertension after treatment with intravenous labetalol or oral nifedipine using color doppler ultrasound.

Study Design: We evaluated thirty pregnant women with gestational age between 28 and 40 weeks in acute severe hypertension (more than or equal to 160/105 mmHg) which were randomly allocated to receive either intravenous labetalol or oral nifedipine until blood pressure was lowered to less than or equal to 140/90 mmHg. Doppler vascular indices namely pulsatility index, resistance index, S/D ratio of bilateral uterine arteries and maternal renal artery were measured baseline at the time of acute severe hypertension and repeated after control of blood pressure, to assess the changes in maternal hemodynamics if any with labetalol or nifedipine. Read More

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http://dx.doi.org/10.1016/j.preghy.2020.05.014DOI Listing

Corrigendum to "Maternal serum lipid levels, oxidative stress and antioxidant activity in pre-eclampsia patients from Southwest India" [Pregnancy Hypertension 15C (2019) 130-133].

Pregnancy Hypertens 2020 Jun 19;21:179. Epub 2020 Jun 19.

Department of Statistics, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.preghy.2020.06.004DOI Listing

[Acetylsalicylic acid in prevention of pre-eclampsia].

Rev Med Inst Mex Seguro Soc 2019 Sep 2;57(5):270-276. Epub 2019 Sep 2.

Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad Hospital de Gíneco-Pediatría No. 48, División de Ginecología y Obstetricia. León, Guanajuato, México.

Background: Pre-eclampsia (PE) is an important cause of morbidity and mortality in our country.

Objective: Evaluate if the administration of acetylsalicylic acid (ASA) at a low dose reduces its presence.

Methods: Comparative, cohort study. Read More

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September 2019