6,032 results match your criteria Hypertension Malignant


The Impact of Obesity in Patients Undergoing Robotic Partial Nephrectomy.

J Endourol 2019 Apr 16. Epub 2019 Apr 16.

Icahn School of Medicine at Mount Sinai, Urology, New York, New York, United States ;

Introduction/background: As the prevalence of obesity increases worldwide, an increasing proportion of surgical candidates have an elevated BMI, with associated metabolic syndrome. Yet there exists limited evidence regarding the effect of elevated BMI on surgical outcomes in robotic surgeries. We examined whether obese patients had worse perioperative outcomes and postoperative renal function following robotic partial nephrectomies (RPNs). Read More

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https://www.liebertpub.com/doi/10.1089/end.2019.0018
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http://dx.doi.org/10.1089/end.2019.0018DOI Listing
April 2019
1 Read

Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

Obes Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Bariatric Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

Background: Obesity is a risk for many different cancers. Laparoscopic sleeve gastrectomy (LSG) is common, and benign or pre-malignant histopathology types are reported in the removed gastric specimens. We assessed whether higher BMI was associated with certain benign or pre-malignant histopathological changes. Read More

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http://dx.doi.org/10.1007/s11695-019-03801-yDOI Listing

identified by comprehensive bioinformatic analysis as a hub candidate biological target in human epithelial ovarian cancer.

Cancer Manag Res 2019 25;11:2379-2392. Epub 2019 Mar 25.

Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China,

Background: Epithelial ovarian cancer (EOC) is a female malignant tumor. Bioinformatics has been widely utilized to analyze genes related to cancer progression. Targeted therapy for specific biological factors has become more valuable. Read More

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http://dx.doi.org/10.2147/CMAR.S189784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438265PMC

A Case of Rheumatoid Arthritis Presenting with Renal Thrombotic Microangiopathy Probably due to a Combination of Chronic Tacrolimus Arteriolopathy and Severe Hypertension.

Case Rep Nephrol 2019 6;2019:3923190. Epub 2019 Mar 6.

Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

A 51-year-old woman with rheumatoid arthritis presented with mild hypertension 20 months after tacrolimus treatment and developing proteinuria 24 months after the treatment. Tacrolimus was discontinued 27 months after the treatment, followed by heavy proteinuria, accelerated hypertension, and deteriorating renal function without ocular fundus lesions as a clinical sign of malignant hypertension. Renal biopsy revealed malignant nephrosclerosis characterized by subacute and chronic thrombotic microangiopathy (TMA), involving small arteries, arterioles, and glomeruli. Read More

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http://dx.doi.org/10.1155/2019/3923190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431373PMC
March 2019
1 Read

Thyroidectomy Complications in Patients with Diabetes Mellitus.

Otolaryngol Head Neck Surg 2019 Apr 9:194599819835793. Epub 2019 Apr 9.

1 Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA.

Objective: To (1) analyze postoperative thyroidectomy outcomes in patients with diabetes mellitus (DM), who are prone to deleterious effects of glucose dysmetabolism, and (2) apply findings to optimize perioperative management of diabetics requiring thyroid surgery.

Study Design: Retrospective database analysis.

Setting: University hospital. Read More

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http://dx.doi.org/10.1177/0194599819835793DOI Listing
April 2019
1 Read

Concomitant primary ovarian paraganglioma neuroendocrinal differentiated urothelial tumor in a BOTOX-injected bladder: A case report.

Int J Surg Case Rep 2019 Mar 28;57:122-125. Epub 2019 Mar 28.

Urology Department, Urology and Nephrology Center, Mansoura University, Egypt.

Introduction: There is no reported data for patients with malignant bladder Botox injection related outcomes. Herein, we reported effect of Botox injection in case of BCG cystitis. In addition, reporting of rare incidence of both primary neuroendocrine differentiation of bladder tumor and primary ovarian paraganglioma post cystectomy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447811PMC
March 2019
1 Read

Mobile Screening Units for the Early Detection of Breast Cancer and Cardiovascular Disease: A Pilot Telemedicine Study in Southern Italy.

Telemed J E Health 2019 Apr 4. Epub 2019 Apr 4.

2 Department of Integrated Telemedicine Services, "Sant'Anna e San Sebastiano" Hospital, Caserta, Italy.

Introduction: Telemedicine is the use of Information and Communication Technologies (ICT) to improve patient outcomes by increasing access to care, medical information and services. The aim of this pilot study was to evaluate and support the implementation of screening and early detection programs in the prevention of breast cancer and cardiovascular diseases with the establishment of a remote diagnosis through the use of ICT in mobile units.

Materials And Methods: A total of 430 individuals were recruited in an area of Southern Italy. Read More

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https://www.liebertpub.com/doi/10.1089/tmj.2018.0328
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http://dx.doi.org/10.1089/tmj.2018.0328DOI Listing
April 2019
4 Reads

Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma.

J Clin Oncol 2019 Apr 2:JCO1801859. Epub 2019 Apr 2.

1 Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Recurrent or metastatic adenoid cystic carcinoma (R/M ACC) is a malignant neoplasm of predominantly salivary gland origin for which effective therapies are lacking. We conducted a phase II trial evaluating the multitargeted tyrosine kinase inhibitor lenvatinib in patients with R/M ACC.

Patients And Methods: This study was conducted with a two-stage minimax design. Read More

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http://dx.doi.org/10.1200/JCO.18.01859DOI Listing
April 2019
3 Reads

Non-contrast MR lymphography of the lymphatic system of the liver.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Faculté de Médecine Pierre et Marie Curie and Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 184 Rue du Faubourg Saint-Antoine, 75012, Paris, France.

This review shows the images obtained with non-contrast MR lymphography in different pathologic conditions affecting the liver. Non-contrast MR lymphography is obtained with a free-breathing 3D high spatial resolution fast-recovery fast spin-echo sequence similar to that used for 3D MR cholangiopancreatography. The liver is the largest lymph-producing organ generating approximately half of the body's lymphatic fluid and is the most important part of the lymphatic system from a functional point of view. Read More

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http://dx.doi.org/10.1007/s00330-019-06151-6DOI Listing
April 2019
3 Reads

Gastrogastric intussusception in adults: a case report with review of the literature.

BJR Case Rep 2018 Dec 10;4(4):20180006. Epub 2018 Jul 10.

Department of Radiology, Good Hope Hospital, Birmingham, UK.

Intussusception of the gastrointestinal viscera is rarely encountered in adult patients and is frequently associated with a polypoidal lead point, which is often malignant. We would like to present the case of a 68-year-old male with a history of decompensated liver disease and multiple medical comorbidities, who was discovered to have an incidental gastrogastric intussusception on CT. No polypoidal lead point was seen and we believe this to be the first case of its kind to be described. Read More

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http://dx.doi.org/10.1259/bjrcr.20180006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438400PMC
December 2018
2 Reads

Indeterminate nodules by the Bethesda system for reporting thyroid cytopathology in Israel: Frequency, and risk of malignancy after reclassification of follicular thyroid neoplasm with papillary-like features.

Eur J Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv Sourasky Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Objective: We aimed to determine the frequency and risk of malignancy (ROM) for indeterminate thyroid nodules, categories III (B3) and IV (B4) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), at a large institution in Israel. Additionally, we investigated the impact of redefining follicular neoplasm with papillary-like nuclear features (NIFTP) as non-malignant on malignancy rates.

Methods: In this retrospective study of all thyroid fine needle aspirations (FNAs) performed at Tel Aviv-Sourasky Medical Center between January 2013 and December 2015, we assessed ROM for B3 and B4 nodules. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.015DOI Listing
March 2019
1 Read

Characterization of pulmonary intimal sarcoma cells isolated from a surgical specimen: In vitro and in vivo study.

PLoS One 2019 29;14(3):e0214654. Epub 2019 Mar 29.

Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba City, Japan.

Pulmonary intimal sarcoma (PIS) constitutes a rare sarcoma originating from the intimal cells of pulmonary arteries. The pathogenesis of PIS remains to be elucidated and specific treatments have not been established; therefore, prognosis is generally poor. The purpose of our study was to isolate and characterize PIS cells from a specimen resected from a patient with PIS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440640PMC
March 2019
4 Reads

Link between Brugada phenocopy and myocardial ischemia: Results from the International Registry on Brugada Phenocopy.

Pacing Clin Electrophysiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Background: Brugada phenocopies clinical entities that have indistinguishable electrocardiographic (ECG) patterns from true congenital Brugada syndrome. However, they are induced by other clinical circumstances such as myocardial ischemia. The purpose of our study was to examine the clinical features and pathogenesis of ischemia-induced Brugada phenocopy (BrP). Read More

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http://dx.doi.org/10.1111/pace.13678DOI Listing
March 2019
3 Reads
1.250 Impact Factor

Resection of a pancreatic capillary lymphatic malformation through a partial pancreatectomy: a case report.

Surg Case Rep 2019 Mar 28;5(1):48. Epub 2019 Mar 28.

Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo, 193-0998, Japan.

Background: Pancreatic vascular malformation causes epigastric pain, pancreatitis, portal vein hypertension, bleeding, and rupture. It is a rare disease, with most pancreatic vascular malformations being arteriovenous malformations (AVMs) and the other types of malformations being rare. We report a case of capillary lymphatic malformation (CLM) in the pancreatic uncinate process. Read More

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http://dx.doi.org/10.1186/s40792-019-0603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439066PMC
March 2019
1 Read

[Corticosurrenaloma: an exceptional cause of primary hyperaldosteronism].

Pan Afr Med J 2018 27;31:60. Epub 2018 Sep 27.

Service d'Endocrinologie et Médecine Interne, Hôpital Tahar Sfar, Mahdia, Tunisie.

Corticosurrenaloma is a rare malignant tumor of the adrenal gland that often secretes corticosteroids, sex steroids and precursors. Aldosterone-producing corticosurrenaloma is very rare, accounting for 1 case/10million inhabitants. We report the case of a 38-year old man presenting with severe arterial hypertension associated with deep hypokalaemia (2. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.60.16973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431414PMC
April 2019
1 Read

Malignant Ischemic Stroke in a Young Female: A Rare Primary Manifestation of Takayasu Arteritis.

Case Rep Neurol Med 2019 18;2019:7942825. Epub 2019 Feb 18.

Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Takayasu arteritis is a rare chronic progressive granulomatous necrotizing large vessel panvasculitis mainly involving aorta and its main branches. It commonly affects the female in second to third decades. Common clinical features of Takayasu arteritis are hypertension, claudication, dizziness, headache, or fever. Read More

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http://dx.doi.org/10.1155/2019/7942825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398056PMC
February 2019
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Hypertensive Choroidopathy Revealing Malignant Hypertension in a Young Patient.

Retina 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, CHU St-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1097/IAE.0000000000002509DOI Listing
March 2019
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Complement in Thrombotic Microangiopathies: Unraveling Ariadne's Thread Into the Labyrinth of Complement Therapeutics.

Front Immunol 2019 27;10:337. Epub 2019 Feb 27.

Division of Biodiagnostic Sciences and Technologies, INRASTES, National Center for Scientific Research Demokritos, Athens, Greece.

Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. We currently recognize two major entities with distinct pathophysiology: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Beyond them, differential diagnosis also includes TMAs associated with underlying conditions, such as drugs, malignancy, infections, scleroderma-associated renal crisis, systemic lupus erythematosus (SLE), malignant hypertension, transplantation, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), and disseminated intravascular coagulation (DIC). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413705PMC
February 2019
2 Reads

Silencing of promotes the epithelial-mesenchymal transition of skin squamous cell carcinoma-derived A431 cells.

Oncol Lett 2019 Apr 6;17(4):3735-3742. Epub 2019 Feb 6.

Division of General Medicine, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan.

Erythropoietin-producing hepatocellular (Eph) receptors and their ligand ephrins serve crucial roles in the interactions among epithelial cells. Eph receptor/ephrin signaling regulates cell functions, including proliferation, differentiation and migration, via these cell-cell interactions. We reported previously that EPHB2, a member of the Eph receptor family, was highly expressed in chemically induced cutaneous squamous cell carcinoma (cSCC) tissues in mice. Read More

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http://dx.doi.org/10.3892/ol.2019.10019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403506PMC
April 2019
1 Read

Analysis of risk factors for deep venous thrombosis in patients with gynecological malignant tumor: A clinical study.

Pak J Med Sci 2019 Jan-Feb;35(1):195-199

Lin Li, Department of Vascular Surgery, Qingdao Hiser Medical Group, Qingdao, Shandong Province, 266033, China.

Objectives: To determine the clinical characteristics and risk factors of Deep Venous Thrombosis (DVT) in patients with gynecological malignant tumor, facilitating gynecologists better prevent the fatal complication.

Methods: The patients with gynecological malignant tumor treated in department of gynecology of our hospital between May 2013 and May 2018 were reviewed retrospectively. The clinical data of patients including gender, age, tumor staging, adenocarcinoma, surgery, operation time, hypertension, hyperlipemia, diabetes, coronary heart disease, radiotherapy, chemotherapy, hospital stay, and postoperative rehabilitation exercise were collected to analyze the clinical characteristics of patients and determine the risk factors of DVT. Read More

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http://dx.doi.org/10.12669/pjms.35.1.365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408657PMC
March 2019
1 Read

The conundrum of postpartum thrombotic Microangiopathy: case report and considerations for management.

BMC Nephrol 2019 Mar 14;20(1):91. Epub 2019 Mar 14.

Department of Internal Medicine, Intensive Care Unit, Medical University Graz, Auenbruggerplatz 15, A-8036, Graz, Austria.

Background: Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic and therapeutic challenge in the evaluation of thrombotic microangiopathies (TMA), where urgent care must be considered.

Case Presentation: We here report the case of a 21-year-old Somali woman, who was delivered by emergency caesarean section at 35 weeks of gestational age with acute dyspnea, placental abruption and gross edema due to severe preeclampsia/HELLP syndrome. After delivery, she developed acute kidney failure and thrombotic microangiopathy as revealed by kidney biopsy. Read More

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http://dx.doi.org/10.1186/s12882-019-1286-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417121PMC
March 2019
1 Read

[Acute shock secondary to congenital neuroblastoma: Neonatal case report].

Arch Argent Pediatr 2019 Apr;117(2):e163-e166

Hospital Universitario Virgen de las Nieves, Servicio de Pediatría, Unidad de Cuidados Intensivos Pediátricos, Granada, España.

Congenital neuroblastoma is the most frequent malignant solid tumor in the neonatal period. The clinical presentation is usually either by prenatal diagnosis or by palpation of an abdominal mass. Staging allows classifying it according to risk groups with a different prognosis and treatment. Read More

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https://www.sap.org.ar/docs/publicaciones/archivosarg/2019/v
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http://dx.doi.org/10.5546/aap.2019.e163DOI Listing
April 2019
4 Reads

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

Takayasu arteritis, malignant hypertension and severe left ventricular hypertrophy.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves¨ University Hospital, Granada, Spain.

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http://dx.doi.org/10.1111/1756-185X.13541DOI Listing
March 2019
1 Read

Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.

Nutrients 2019 Mar 9;11(3). Epub 2019 Mar 9.

Departamento de Biomedicina-Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.

Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Read More

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https://www.mdpi.com/2072-6643/11/3/583
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http://dx.doi.org/10.3390/nu11030583DOI Listing
March 2019
5 Reads

Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations.

J Clin Anesth 2019 Mar 7;57:41-49. Epub 2019 Mar 7.

The Ohio State University Wexner Medical Center, Department of Anesthesiology, Doan Hall 520, 410 W 10th Ave, Columbus 43210, OH, USA; The Ohio State University Wexner Medical Center, Department of Neurological Surgery, 410 W 10th Ave, Columbus 43210, OH, USA. Electronic address:

According to the 2015 National Survey on Drug Use and Health, marijuana continues to be the most common illicit recreational drug used in the US. Cannabis is associated with systemic reactions that potentially affect perioperative outcomes. We have reviewed the most important pharmacological aspects and pathophysiological effects that should be considered during the perioperative management of chronic cannabis/cannabinoids users. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.03.011DOI Listing
March 2019
2 Reads

Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain.

Hepatobiliary Pancreat Dis Int 2019 Feb 28. Epub 2019 Feb 28.

Starzl Abdominal Transplant Unit, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Avenue Hippocrates 10, 1200 Brussels, Belgium. Electronic address:

Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation (LDLT) is presented. Read More

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http://dx.doi.org/10.1016/j.hbpd.2019.02.007DOI Listing
February 2019
1 Read

Current and future pharmacological therapies for managing cirrhosis and its complications.

World J Gastroenterol 2019 Feb;25(8):888-908

Liver Unit/Division of Integrative Systems Medicine and Digestive Disease, Imperial College London, London W2 1NY, United Kingdom.

Due to the restrictions of liver transplantation, complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis. This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications, together with discussion of current controversies and potential future directions. PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety, efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i8.888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397723PMC
February 2019
8 Reads

Tubuloids derived from human adult kidney and urine for personalized disease modeling.

Nat Biotechnol 2019 03 4;37(3):303-313. Epub 2019 Mar 4.

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences, Utrecht, the Netherlands.

Adult stem cell-derived organoids are three-dimensional epithelial structures that recapitulate fundamental aspects of their organ of origin. We describe conditions for the long-term growth of primary kidney tubular epithelial organoids, or 'tubuloids'. The cultures are established from human and mouse kidney tissue and can be expanded for at least 20 passages (>6 months) while retaining a normal number of chromosomes. Read More

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http://www.nature.com/articles/s41587-019-0048-8
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http://dx.doi.org/10.1038/s41587-019-0048-8DOI Listing
March 2019
15 Reads

A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma.

Radiother Oncol 2019 Mar 21;132:34-41. Epub 2018 Dec 21.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:

Background And Purpose: This study sought to develop and validate a nomogram to predict cerebrovascular disease (CVD) among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma (NPC).

Materials And Methods: A total of 346 eligible patients with brain necrosis after radiotherapy for NPC were divided into a training set (n = 231) and a validation set (n = 115). A multivariate Cox proportional hazards regression model was used to select the significant variables for CVD prediction in the training set. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01678140183360
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http://dx.doi.org/10.1016/j.radonc.2018.11.008DOI Listing
March 2019
7 Reads

Pathogenic role of angiotensin II and the NF-κB system in a model of malignant hypertensive nephrosclerosis.

Hypertens Res 2019 Feb 26. Epub 2019 Feb 26.

Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo São Paulo, São Paulo, Brazil.

We previously reported that rats treated with an NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC), during lactation developed hypertension in adult life, without apparent functional or structural damage to kidneys, providing a new model of essential hypertension. Here, we investigated whether uninephrectomy associated with salt overload would unveil a latent renal dysfunction in this model, aggravating arterial hypertension and promoting renal injury. Male Munich-Wistar rat pups received PDTC from maternal milk (PDTC) from 0 to 20 days after birth. Read More

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http://dx.doi.org/10.1038/s41440-019-0226-6DOI Listing
February 2019
3 Reads

Malignant Middle Cerebral Artery Infarction Due to Hyponatremia Following Traumatic Brain Injury: A Case Report.

Am J Case Rep 2019 Feb 27;20:258-262. Epub 2019 Feb 27.

Department of Neurosurgery, Southeastern Regional Medical Center, Lumberton, NC, USA.

BACKGROUND Development of syndrome of inappropriate antidiuretic hormone secretion or cerebral salt wasting has been commonly noted in post-traumatic brain injury, and this condition may lead to hyponatremia resulting in cerebral edema and possible cerebral herniation. However, the predominant topographic pattern of edema from hyponatremia has not been well documented. Unlike numerous reports on hyponatremia and vasospasm following aneurysmal subarachnoid hemorrhage, the data for traumatic brain injury patient are still limited. Read More

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http://dx.doi.org/10.12659/AJCR.913872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402275PMC
February 2019
2 Reads

Inhibition of Src activation reverses pulmonary vascular remodeling in experimental pulmonary arterial hypertension via Akt/mTOR/HIF-1 signaling pathway.

Exp Cell Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address:

Pulmonary arterial hypertension (PAH) is a diffuse pulmonary microvascular remodeling disease accompanied by malignant proliferation of pulmonary artery smooth muscle cells (PASMCs), which causes persistent pulmonary artery pressure elevation, right ventricular hypertrophy (RVH) and death. However, current therapies targeting pulmonary vascular remodeling and RVH remain poorly effective in reversing PAH. Overactivation of the protein tyrosine kinase Src plays an important role in tumor cell growth, proliferation and invasion; we thus hypothesized that inhibitors targeting Src activation could reverse experimental PAH. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.022DOI Listing
February 2019
4 Reads

[Acute kidney injury related to acute vascular disorders].

Rev Prat 2018 Feb;68(2):166-169

Service de néphrologie et transplantation, CHU Henri-Mondor, université Paris-Est Créteil, Créteil, France.

Acute kidney injury related to acute vascular disorders. A broad spectrum of vascular disease characterized by primary vessel involvement may be associated with acute renal failure. These diseases are usually classified according to the size of the injured vessel that include the small vessels (thrombotic microangiopathy, kidney injury due to malignant hypertension, scleroderma renal crisis, and cholesterol crystal embolism disease), the medium vessels (polyarteritis nodosa) or the large size vessels (acute renal infarction). Read More

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February 2018

Gynecomastia - Conservative and Surgical Management.

Authors:
Kristin Baumann

Breast Care (Basel) 2018 Dec 14;13(6):419-424. Epub 2018 Nov 14.

Clinic for Gynecology and Obstetrics, University Medical Centre Schleswig-Holstein Campus Lübeck, Lübeck, Germany.

Gynecomastia is defined as a unilateral or bilateral persistent benign mammary gland enlargement in men. Prevalence of asymptomatic gynecomastia is up to 65%. True gynecomastia must be distinguished from pseudogynecomastia. Read More

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https://www.karger.com/Article/FullText/494276
Publisher Site
http://dx.doi.org/10.1159/000494276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381901PMC
December 2018
5 Reads

Platelet-lymphocyte ratio (PLR) and all-cause mortality in general population: insights from national health and nutrition education survey.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Division of Hospital Medicine , Virginia Commonwealth University , Richmond , VA , USA.

Platelet lymphocyte ratio (PLR) is a novel marker of inflammation that has gained popularity, especially in prognostication of cardiac diseases and malignant conditions. Several studies have examined the relationship between PLR and disease-specific mortality but none has examined this relationship with all-cause mortality in general population. Therefore, we examined the relationship between PLR and all-cause mortality using data from the National Health and Nutrition Examination Survey (NHANES) from the year 1999 to 2010. Read More

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http://dx.doi.org/10.1080/09537104.2019.1571188DOI Listing
February 2019
5 Reads

Irbesartan Induced Cutaneous Melanoma! Second Case in the Medical Literature!

Open Access Maced J Med Sci 2019 Jan 9;7(1):121-123. Epub 2019 Jan 9.

Medical Institute of the Ministry of Interior, Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Drug-induced melanoma is a topic, concept or "reality" becoming more and more popular as the list of drugs considered as potential inducers of cutaneous melanoma is constantly growing. Interesting and current at the moment is the question/dilemma of "Irbesartan induced melanomas" and "Valsartan induced melanomas"! The following questions are without answers: 1) the general risk which angiotensin receptor blockers contain for potentiating the carcinogenesis and cancer development (as a whole); 2) available officialized data for withdrawal from the market of products with valsartan and irbesartan due to detected potential carcinogens-NDMA/NDEA, and 3) the missing official information on the most likely forms of cancer potentiated by these drugs. That is precisely why many questions remain open, and the inevitable assumption arises for the key, although according to some conspiratorial role of so-called "pharmaceutical giants" in the concept of drug-induced malignancies. Read More

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http://dx.doi.org/10.3889/oamjms.2019.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352483PMC
January 2019
6 Reads

Drug-Induced Melanoma: Irbesartan Induced Cutaneous Melanoma! First Description in the World Literature!

Open Access Maced J Med Sci 2019 Jan 9;7(1):114-116. Epub 2019 Jan 9.

Medical Institute of the Ministry of Interior, Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Melanoma appears to be a malignant disease, whose development can be potentiated by different drug groups. More and more data are in favour of the claim that commonly used antihypertensive drugs also contain the risk of developing melanoma. The most evidence is that angiotensin receptor blockers may be carcinogenic. Read More

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http://dx.doi.org/10.3889/oamjms.2019.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352467PMC
January 2019
1 Read

Bacterial peritonitis in a patient with malignant ascites caused by pancreatic carcinoma: Case report and review of literature.

J Infect Chemother 2019 Feb 6. Epub 2019 Feb 6.

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

Bacterial peritonitis, an infection of the ascitic fluid, can be classified etiologically as spontaneous or secondary bacterial peritonitis. The former is mainly caused by portal hypertension and its subsequent effects, whereas the latter is caused by the direct dissemination of bacteria into the peritoneal cavity. Previous reports have described some distinguishing features of these two entities. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.007DOI Listing
February 2019
2 Reads
1.384 Impact Factor

Kidney disease and plasma cell dyscrasias: ambiguous cases solved by serum free light chain dimerization analysis.

Clin Exp Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of FMF and Amyloidosis, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, 52621, Ramat Gan, Israel.

Background: Plasma cell dyscrasias (PCD) comprise a wide spectrum of disorders, which may adversely affect the kidney. However, in some PCD cases associated with kidney disease, the routine laboratory tests may be incapable to determine precisely the form of PCD, i.e. Read More

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http://dx.doi.org/10.1007/s10157-019-01699-5DOI Listing
February 2019
2 Reads
1.708 Impact Factor

Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the "Hartel's Route".

J Neurol Surg B Skull Base 2019 Feb 8;80(1):105-108. Epub 2018 Jun 8.

Department of NESMOS (Neurosciences Mental Health and Sensory Organs), School of Medicine and Psychology, "Sant'Andrea" Hospital, "Sapienza" University of Rome, Rome, Italy.

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. Read More

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http://dx.doi.org/10.1055/s-0038-1657794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365233PMC
February 2019
1 Read

Misdiagnosed Malignant Tumor on an Ischemic Limb.

Wounds 2019 Feb;31(2):E12-E13

Hospital de Cabueñes, Gijon, Asturias, Spain.

Introduction: Acral lentiginous melanoma (ALM) is a rare variety of melanoma typically located on distal areas of the body. Due to its presentation, it can be confused with a vascular ulcer.

Case Report: The authors present the case of a 68-year-old man who smokes with a history of hypertension, diabetes, and dyslipidemia, who was referred to the vascular clinic with complaints of intermittent claudication and a developing ulcer on his heel. Read More

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February 2019
7 Reads

Adrenocorticotropic Hormone-Dependent Cushing Syndrome Caused by an Olfactory Neuroblastoma.

Clin Med Insights Endocrinol Diabetes 2019 31;12:1179551419825832. Epub 2019 Jan 31.

Department of Endocrinology, Hospital Clinico San Carlos, Madrid, Spain.

Olfactory neuroblastoma (ONB) is an unusual malignant neoplasm originating from the olfactory neuroepithelium. Secretion of adrenocorticotropic hormone (ACTH) from this tumor has been exceptionally reported. We describe a young man with resistant hypertension and a cushingoid phenotype. Read More

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http://dx.doi.org/10.1177/1179551419825832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357293PMC
January 2019
1 Read

National Survey of Morbidity and Risk Factors (EMENO): Protocol for a Health Examination Survey Representative of the Adult Greek Population.

JMIR Res Protoc 2019 Feb 4;8(2):e10997. Epub 2019 Feb 4.

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Main causes of death in Greece are cardiovascular diseases (CVDs), malignant neoplasms, respiratory diseases, and road traffic crashes. To assess the population health status, monitor health systems, and adjust policies, national population-based health surveys are recommended. The previous health surveys that were conducted in Greece were restricted to specific regions or high-risk groups. Read More

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http://dx.doi.org/10.2196/10997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378546PMC
February 2019
9 Reads

Hypertensive choroidopathy: Multimodal imaging and the contribution of wide-field swept-source oct-angiography.

Am J Ophthalmol Case Rep 2019 Mar 9;13:131-135. Epub 2019 Jan 9.

Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France.

Purpose: To present the case of a patient with a hypertensive choroidopathy and her follow-up using multimodal imaging; and to assess how wide-field swept-source (SS) Optical Coherence Tomography Angiography (OCTA) contributes to detecting the areas of hypoperfusion.

Observations: A 25-year-old white woman with terminal renal insufficiency, myopericarditis, and cerebrospinal fluid pressure of 37 mmHg indicating intracranial hypertension, presented with a painless loss of vision in both eyes. Her blood pressure was 190/135 mmHg. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348489PMC
March 2019
2 Reads

Salivary malignancies- medical, demographic and diagnostic analysis.

J Craniomaxillofac Surg 2019 Mar 11;47(3):500-504. Epub 2019 Jan 11.

Department of Oral and Maxillofacial Surgery, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel; Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address:

We examined systemic medical and demographic characteristics of patients diagnosed with salivary malignant tumors in order to better understand the pathogenesis of the disease. Of 101 patients who received definitive treatment for malignant salivary gland tumors in our medical center, 22 died with disease (DwD) and were compared with the remaining 79 patients (Other). Mean ages were 66. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.01.006DOI Listing
March 2019
1 Read

[Progress in Systemic Sclerosis - Early, Targeted and Intensive Therapy is the Key to Success].

Dtsch Med Wochenschr 2019 Feb 31;144(3):189-193. Epub 2019 Jan 31.

Klinik für Rheumatologie und Klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck.

This literature review summarizes the main findings in systemic sclerosis (SSc) made in the last few years. Accordingly, the disease pathogenesis is mainly driven by the adaptive immune system, which is proven by the effects of autologous stem cell transplantation. Particularly, autoantibodies can activate both adaptive as well as innate immune cells as identified for the anti-angiotensin receptor antibodies. Read More

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http://dx.doi.org/10.1055/a-0652-2488DOI Listing
February 2019
12 Reads

[Esophageal Cancer Surgery in Elderly Patients Aged 80 Years or Older].

Gan To Kagaku Ryoho 2018 Dec;45(13):2123-2125

Dept. of Surgery, Tokyo Women's Medical University Medical Center East.

As the population ages, the elderly are increasingly affected by esophageal cancer. We reviewed the data of elderly patients, 80 years old or older, who underwent surgery for esophageal cancer to evaluate the safety of surgery in this particular patient population. Twenty-two patients aged 80 or above underwent surgery for esophageal cancer in our department. Read More

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December 2018
1 Read

Diagnostic accuracy of CA125 and HE4 in ovarian carcinoma patients and the effect of confounders on their serum levels.

Curr Probl Cancer 2019 Jan 16. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt.

Objectives: To evaluate the diagnostic accuracy of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in the prediction of malignant ovarian masses then to analyze the effect of personal criteria and medical diseases on this accuracy.

Study Design: This prospective study was performed in Zagazig University Hospital. The eligibility criteria for inclusion were; consecutive women, at any age ≥18 years, with established diagnosis of ovarian mass based on symptoms, signs, and imaging techniques. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.12.004DOI Listing
January 2019
2 Reads

Optical coherence tomography angiography findings in malignant hypertensive retinopathy.

Arq Bras Oftalmol 2019 Jan-Feb;82(1):72-77

Department of Ophthalmology, Antalya Education and Research Hospital, Antalya, Turkey.

A 33-year-old male presented to our clinic with low vision in both eyes that started during the previous week. Visual acuity was 20/63 in the right eye and 20/50 in the left eye. Fundus examination revealed signs of hypertensive retinopathy; thus, a multidisciplinary approach was adopted for the diagnosis and treatment of this patient. Read More

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http://dx.doi.org/10.5935/0004-2749.20190015DOI Listing
March 2018
7 Reads
0.440 Impact Factor