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Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Division of Hospital Medicine , Virginia Commonwealth University , Richmond , VA , USA.

Platelet lymphocyte ratio (PLR) is a novel marker of inflammation that has gained popularity, especially in prognostication of cardiac diseases and malignant conditions. Several studies have examined the relationship between PLR and disease-specific mortality but none has examined this relationship with all-cause mortality in general population. Therefore, we examined the relationship between PLR and all-cause mortality using data from the National Health and Nutrition Examination Survey (NHANES) from the year 1999 to 2010. Read More

Open Access Maced J Med Sci 2019 Jan 9;7(1):121-123. Epub 2019 Jan 9.

Medical Institute of the Ministry of Interior, Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Drug-induced melanoma is a topic, concept or "reality" becoming more and more popular as the list of drugs considered as potential inducers of cutaneous melanoma is constantly growing. Interesting and current at the moment is the question/dilemma of "Irbesartan induced melanomas" and "Valsartan induced melanomas"! The following questions are without answers: 1) the general risk which angiotensin receptor blockers contain for potentiating the carcinogenesis and cancer development (as a whole); 2) available officialized data for withdrawal from the market of products with valsartan and irbesartan due to detected potential carcinogens-NDMA/NDEA, and 3) the missing official information on the most likely forms of cancer potentiated by these drugs. That is precisely why many questions remain open, and the inevitable assumption arises for the key, although according to some conspiratorial role of so-called "pharmaceutical giants" in the concept of drug-induced malignancies. Read More

Open Access Maced J Med Sci 2019 Jan 9;7(1):114-116. Epub 2019 Jan 9.

Medical Institute of the Ministry of Interior, Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Melanoma appears to be a malignant disease, whose development can be potentiated by different drug groups. More and more data are in favour of the claim that commonly used antihypertensive drugs also contain the risk of developing melanoma. The most evidence is that angiotensin receptor blockers may be carcinogenic. Read More

J Infect Chemother 2019 Feb 6. Epub 2019 Feb 6.

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

Bacterial peritonitis, an infection of the ascitic fluid, can be classified etiologically as spontaneous or secondary bacterial peritonitis. The former is mainly caused by portal hypertension and its subsequent effects, whereas the latter is caused by the direct dissemination of bacteria into the peritoneal cavity. Previous reports have described some distinguishing features of these two entities. Read More

Clin Exp Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of FMF and Amyloidosis, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, 52621, Ramat Gan, Israel.

Background: Plasma cell dyscrasias (PCD) comprise a wide spectrum of disorders, which may adversely affect the kidney. However, in some PCD cases associated with kidney disease, the routine laboratory tests may be incapable to determine precisely the form of PCD, i.e. Read More

J Neurol Surg B Skull Base 2019 Feb 8;80(1):105-108. Epub 2018 Jun 8.

Department of NESMOS (Neurosciences Mental Health and Sensory Organs), School of Medicine and Psychology, "Sant'Andrea" Hospital, "Sapienza" University of Rome, Rome, Italy.

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. Read More

Wounds 2019 Feb;31(2):E12-E13

Hospital de Cabueñes, Gijon, Asturias, Spain.

Introduction: Acral lentiginous melanoma (ALM) is a rare variety of melanoma typically located on distal areas of the body. Due to its presentation, it can be confused with a vascular ulcer.

Case Report: The authors present the case of a 68-year-old man who smokes with a history of hypertension, diabetes, and dyslipidemia, who was referred to the vascular clinic with complaints of intermittent claudication and a developing ulcer on his heel. Read More

Clin Med Insights Endocrinol Diabetes 2019 31;12:1179551419825832. Epub 2019 Jan 31.

Department of Endocrinology, Hospital Clinico San Carlos, Madrid, Spain.

Olfactory neuroblastoma (ONB) is an unusual malignant neoplasm originating from the olfactory neuroepithelium. Secretion of adrenocorticotropic hormone (ACTH) from this tumor has been exceptionally reported. We describe a young man with resistant hypertension and a cushingoid phenotype. Read More

JMIR Res Protoc 2019 Feb 4;8(2):e10997. Epub 2019 Feb 4.

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Main causes of death in Greece are cardiovascular diseases (CVDs), malignant neoplasms, respiratory diseases, and road traffic crashes. To assess the population health status, monitor health systems, and adjust policies, national population-based health surveys are recommended. The previous health surveys that were conducted in Greece were restricted to specific regions or high-risk groups. Read More

Am J Ophthalmol Case Rep 2019 Mar 9;13:131-135. Epub 2019 Jan 9.

Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France.

Purpose: To present the case of a patient with a hypertensive choroidopathy and her follow-up using multimodal imaging; and to assess how wide-field swept-source (SS) Optical Coherence Tomography Angiography (OCTA) contributes to detecting the areas of hypoperfusion.

Observations: A 25-year-old white woman with terminal renal insufficiency, myopericarditis, and cerebrospinal fluid pressure of 37 mmHg indicating intracranial hypertension, presented with a painless loss of vision in both eyes. Her blood pressure was 190/135 mmHg. Read More

J Craniomaxillofac Surg 2019 Mar 11;47(3):500-504. Epub 2019 Jan 11.

Department of Oral and Maxillofacial Surgery, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel; Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address:

We examined systemic medical and demographic characteristics of patients diagnosed with salivary malignant tumors in order to better understand the pathogenesis of the disease. Of 101 patients who received definitive treatment for malignant salivary gland tumors in our medical center, 22 died with disease (DwD) and were compared with the remaining 79 patients (Other). Mean ages were 66. Read More

Dtsch Med Wochenschr 2019 Feb 31;144(3):189-193. Epub 2019 Jan 31.

Klinik für Rheumatologie und Klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck.

This literature review summarizes the main findings in systemic sclerosis (SSc) made in the last few years. Accordingly, the disease pathogenesis is mainly driven by the adaptive immune system, which is proven by the effects of autologous stem cell transplantation. Particularly, autoantibodies can activate both adaptive as well as innate immune cells as identified for the anti-angiotensin receptor antibodies. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2123-2125

Dept. of Surgery, Tokyo Women's Medical University Medical Center East.

As the population ages, the elderly are increasingly affected by esophageal cancer. We reviewed the data of elderly patients, 80 years old or older, who underwent surgery for esophageal cancer to evaluate the safety of surgery in this particular patient population. Twenty-two patients aged 80 or above underwent surgery for esophageal cancer in our department. Read More

Curr Probl Cancer 2019 Jan 16. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt.

Objectives: To evaluate the diagnostic accuracy of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in the prediction of malignant ovarian masses then to analyze the effect of personal criteria and medical diseases on this accuracy.

Study Design: This prospective study was performed in Zagazig University Hospital. The eligibility criteria for inclusion were; consecutive women, at any age ≥18 years, with established diagnosis of ovarian mass based on symptoms, signs, and imaging techniques. Read More

Arq Bras Oftalmol 2019 Jan-Feb;82(1):72-77

Department of Ophthalmology, Antalya Education and Research Hospital, Antalya, Turkey.

A 33-year-old male presented to our clinic with low vision in both eyes that started during the previous week. Visual acuity was 20/63 in the right eye and 20/50 in the left eye. Fundus examination revealed signs of hypertensive retinopathy; thus, a multidisciplinary approach was adopted for the diagnosis and treatment of this patient. Read More

Case Rep Nephrol 2018 17;2018:3273695. Epub 2018 Dec 17.

Department of Nephrology, Austin Health, Studley Road, Heidelberg 3084, Victoria, Australia.

Background: Pulmonary-renal syndrome is characterised by acute kidney injury, haematuria, and haemoptysis and is a well-recognised presentation of diseases such as ANCA vasculitis that require urgent immunosuppression.

Case Presentation: A patient presented with a brief history of haemoptysis, acute renal failure, microscopic haematuria, and severe hypertension. The diagnosis was initially not clear so he was treated with antihypertensives, renal replacement therapy, and immunosuppression. Read More

Eur Radiol 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiology, Bolzano Central Hospital, via Boehler 5, 39100, Bolzano, Italy.

Objectives: To correlate the degree of ascites enhancement during hepatobiliary phase after gadobenate dimeglumine (Gd-BOPTA) administration with ascites aetiology.

Methods: IRB-approved retrospective study, need for informed consent was waived. We included 74 consecutive ascitic patients who underwent Gd-BOPTA-enhanced liver MRI including hepatobiliary phase (HBP) images between January 2014 and December 2017. Read More

World Neurosurg 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurosurgery, Augusta University Medical Center, Augusta, Georgia, United States.

Object: Hemicraniectomy is a commonly performed neurosurgical procedure used in the setting of medically refractory malignant intracranial hypertension. Complications from cranioplasty following hemicraniectomy can be significant, including infection and wound issues. Difficulty with scar tissue during exposure for cranioplasty can be challenging and can lead to prolonged surgical time and increased bleeding. Read More

J Hypertens 2019 Feb;37(2):282-283

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham.

J Bras Nefrol 2019 Jan 10. Epub 2019 Jan 10.

Hospital Geral de Fortaleza, Departamento de Nefrologia, Fortaleza, CE, Brasil.

Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Read More

Mol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain.

The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. While several clinical studies show a higher incidence of CC and a lower survival rate in diabetics, others report no association. Our own experience indicates that diabetes does not seem to worsen the prognosis once the tumor is present. Read More

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan. Electronic address:

Background: We redesigned decompressive craniectomy and cranioplasty procedures to decrease the inherent risk of complications. This novel technique, called decompressive cranioplasty, not only may decrease the complication rate but also may improve the cosmetic result, obviate the need for artificial skull implant, and increase the decompressive volume compared with traditional craniectomy.

Methods: In decompressive cranioplasty, the Agnes Fast craniotomy was adopted without cutting the temporalis muscle from the underlying bone flap. Read More

Hum Pathol 2018 Dec 27. Epub 2018 Dec 27.

Central Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

The immunosuppressive effect of the programmed death (PD)-1/PD-L1 pathway plays an important role in the treatment of a variety of tumors, such as lung and breast cancer, but there is little literature about PD-1/PD-L1 in pheochromocytomas/paragangliomas (PCC/PGLs). We explored the relationship of PD-L1 and malignant behavior in 77 cases of PCC/PGL using immunohistochemistry (IHC) to assess protein expression and RNAscope to detect mRNA expression in 20 cases. The IHC data showed that 59. Read More

Malays J Pathol 2018 Dec;40(3):331-335

Toranomon Hospital, Department of Digestive Surgery, Hepatobiliary-pancreatic Surgery Division, Tokyo, Japan.

Introduction: We report a case of intrahepatic cholangiocarcinoma and portal hypertension developing in a liver with biliary microhamartomas (von Meyenburg's complex).

Case Report: The patient was a 55-year-old man who had a past medical history of diffuse multiple liver abscesses. During follow-up examination, a hypovascular nodule measuring 2. Read More

Lancet Oncol 2019 Jan 18;20(1):134-144. Epub 2018 Dec 18.

Department of Medical Oncology, University Hospital of Canarias, Tenerife, Spain.

Background: A solitary fibrous tumour is a rare soft-tissue tumour with three clinicopathological variants: typical, malignant, and dedifferentiated. Preclinical experiments and retrospective studies have shown different sensitivities of solitary fibrous tumour to chemotherapy and antiangiogenics. We therefore designed a trial to assess the activity of pazopanib in a cohort of patients with malignant or dedifferentiated solitary fibrous tumour. Read More

Cardiovasc Res 2019 Jan;115(1):204-212

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland.

Aims: Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. Read More

Brain Behav 2018 Dec 22;8(12):e01158. Epub 2018 Nov 22.

Department of Neurology, People's Hospital of Deyang City, Deyang, China.

Objective: We aimed to investigate age-specific clinical characteristics in patients aged >60 years with large hemispheric infarction (LHI).

Methods: We prospectively enrolled consecutive patients with LHI. Patients were divided into two groups: ≤60 vs. Read More

J Cardiovasc Nurs 2018 Dec 17. Epub 2018 Dec 17.

Lei Chen, PhD Research Fellow, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne. Yih-Kai Chan, PhD Research Fellow, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne. Lucy Busija, PhD Senior Research Fellow, Institute for Health and Ageing, Australian Catholic University, Melbourne. Tone M. Norekval, PhD Professor, Department of Heart Disease, Haukeland University Hospital; and Department of Clinical Science, University of Bergen, Bergen, Norway. Barbara Riegel, PhD Professor, Biobehavioral Health Sciences Department, School of Nursing, University of Pennsylvania, Philadelphia. Simon Stewart, PhD Professor, Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia.

Background: The impact of different patterns of multimorbidity in heart failure (HF) on health outcomes is unknown.

Objectives: The aim of this study was to test the hypothesis that, independent of the extent of comorbidity, there are distinctive phenotypes of multimorbidity that convey an increased risk for premature mortality in patients hospitalized with HF.

Methods: We analyzed the clinical profile and health outcomes of 787 patients hospitalized with HF participating in a multidisciplinary HF management program with a minimum 12-month follow-up. Read More

J Physiol 2018 Dec 15. Epub 2018 Dec 15.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Yawkey Suite 5B, Boston, MA, USA.

Key Points: Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle: weight gain, hypertension, hyperlipidaemia, insulin resistance, coronary artery disease, and increased morbidity and mortality. We show that plasma catecholamine levels remain stably low at exercise intensities below the ventilatory threshold, a parameter that can be defined during cardiopulmonary exercise testing, but rise rapidly at higher intensities of exercise. Read More

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):819-824

Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.

Objective: The objective of this study was to determine the effectiveness of bevacizumab (BV) in combination with chemotherapeutic regimens for prolonging progression-free survival (PFS) as well as overall survival (OS) in patients with platinum-refractory ovarian cancer.

Materials And Methods: We retrospectively reviewed the medical records of platinum-refractory ovarian cancer patients receiving chemotherapy between January 2010 and August 2015 in the Department of Gynecology at the Saitama Medical Center, Jichi Medical University. After excluding for prior malignant disease, 57 patients were enrolled. Read More

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):289-292

Armed Forces Hospital. Brasília-DF, Brazil.

This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Read More

Hypertens Res 2018 Dec 10. Epub 2018 Dec 10.

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Suboptimal conditions during prenatal and early postnatal development can increase risk of hypertension later in life. We studied consequences of a changed perinatal environment by initiating the cross-fostering of homozygous Ren-2 transgenic rat (TGR) offspring to normotensive, transgene-negative control mothers, and vice versa. We hypothesized that cross-fostering to a normotensive female can attenuate the development of malignant hypertension in TGR offspring (TGRx) and change their salt-sensitive response. Read More

Clin Transplant 2019 Jan 30;33(1):e13459. Epub 2018 Dec 30.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (Pediatrics), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognized serious complication of cyclosporine A (CSA) and tacrolimus (TAC) use in hematopoietic cell transplantation (HCT) recipients.

Procedure: A retrospective study was carried out, including 84 cases of HCT for TM from January 2012 to January 2017. Eleven cases were diagnosed with PRES. Read More

J Pak Med Assoc 2018 Dec;68(12):1854-1858

Jinnah Sindh Medical University, Karachi.

Pheochromocytoma, a rare tumour, arises mainly in the adrenal gland. It consists of chromaffin cells or sympathetic para-ganglia if extra-adrenal. It is an occurrence of rare nature with an incidence of two to eight cases per million annually. Read More

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, "Spedali Civili" Children's Hospital, 25123, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.

Introduction: Biliary atresia (BA) represents the leading indication for liver transplantation in childhood. Only few studies reported the outcome of patients who survived more than 20 years on their native liver, and up to date there are no Italian data available. We reported our 40-year single centre experience with long-term follow-up of BA patients. Read More

Inhal Toxicol 2018 Aug - Aug;30(9-10):327-334. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

World J Nephrol 2018 Nov;7(7):143-147

Division of Nephrology, Department of Medicine, Tygerberg Hospital and Stellenbosch University, Cape Town 7505, South Africa.

Renal artery stenosis is a common cause of secondary hypertension and chronic kidney disease. We present here a case of fibromuscular dysplasia that was treated with surgical revascularization, resulting in recovery of kidney function with eventual cessation of chronic dialysis. The case involves a 25-year-old female with coincidentally discovered hypertension, who underwent further investigations revealing a diagnosis of renal artery stenosis due to fibromuscular dysplasia. Read More

JAMA Otolaryngol Head Neck Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Anesthesiology, University of California, San Diego, La Jolla.

Importance: Despite the ease of preoperative anemia diagnosis and the availability of treatment options, the morbidity and mortality associated with this condition remain unacceptably high, and the literature describing the association of preoperative anemia with postoperative outcomes following thyroid surgery in patients with thyroid cancer remain sparse. Reporting outcomes in this patient population may help to facilitate preoperative optimization.

Objective: To assess whether an association exists between preoperative anemia and outcomes following thyroid surgery in patients with thyroid cancer. Read More

Cureus 2018 Sep 24;10(9):e3348. Epub 2018 Sep 24.

Cardiothoracic Surgery, The Aga Khan University Hospital, Karachi, PAK.

Pheochromocytoma is a rare benign tumor of the adrenal gland. A select few cases may be malignant, and metastatic cases are exceedingly rare. It often presents with symptoms of catecholamine excess, such as sweating, palpitations, headaches, and characteristic paroxysmal hypertension. Read More

Am J Cardiol 2019 Jan 30;123(2):249-253. Epub 2018 Oct 30.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

The pathophysiology of spontaneous coronary artery dissection (SCAD) is heterogeneous, associated with systemic arteriopathies and inflammatory diseases, and often compounded by environmental precipitants, genetics, or stressors. However, the frequency of these associated conditions with SCAD on a population level remains unknown. Therefore, the objective of this analysis was to evaluate heterogeneous phenotypes of SCAD in the United States using data from the Nationwide Inpatient Sample collected from January 1, 2004, to September 31, 2015. Read More

Case Rep Pathol 2018 24;2018:6407360. Epub 2018 Oct 24.

Department of Urology, Sakai City Hospital Organization, Sakai City Medical Center, Sakai, Japan.

Juxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. Read More

Int Forum Allergy Rhinol 2019 Feb 23;9(2):220-224. Epub 2018 Nov 23.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and complications of sinonasal cancer (SNC) patients receiving surgery. Read More

Nutr Cancer 2018 Nov 17:1-6. Epub 2018 Nov 17.

a Department of Medical Oncology , Fujian Cancer Hospital, Fujian Medical University Cancer Hospital , Fuzhou , Fujian , China.

Background: The level of the systemic inflammatory marker C-reactive protein (CRP) is elevated in many patients with malignant disease and may be related to nutritional status.

Objective: To analyze the association between serum CRP levels in patients with malignant tumors and their nutritional status.

Method: A total of 3,692 cases were analyzed and the serum CRP levels were determined using an immunometric assay. Read More

J Dermatol 2019 Feb 16;46(2):95-102. Epub 2018 Nov 16.

Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The relationship between psoriasis and cancer has not yet been established. The aim of this study was to evaluate the association of psoriasis with certain cancers using national statistics. All patients with psoriasis (n = 892 089; 51. Read More

Saudi J Anaesth 2018 Oct-Dec;12(4):626-628

Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, Michigan, USA.

The prevalence of tracheal stents has increased in the past two decades for the management of malignant and benign central airway diseases for either palliation or definitive therapy. Recent placement of a tracheal stent has been associated with edema of the upper airway; therefore, these patients are at a great risk for airway collapse, especially within the days most recent to the procedure. The authors present the case of a morbidly obese patient with a tracheal stent admitted to the Intensive Care Unit who developed acute respiratory failure and was found to be "unable to ventilate, unable to intubate. Read More

Lung Cancer 2018 Nov 14;125:100-102. Epub 2018 Sep 14.

Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Virginia Tech Carilion School of Medicine, 1906 Belleview Ave Roanoke VA, 24014, United States.

Hyalinizing clear cell carcinomas (HCCC), now referred to as clear cell carcinomas (CCC) by the World Health Organization (WHO), are rare tumors usually arising from the salivary glands of the head and neck. We present the first case of a CCC originating from the trachea. A 66 year-old woman with history of hypertension, former smoker, presented to the emergency department reporting worsening shortness of breath. Read More

Medicine (Baltimore) 2018 Nov;97(45):e13105

Department of Oncology of 363 Hospital, Cheng Du.

Rationale: Malignant Pleural Mesothelioma (MPM) is rare cancer and has a poor prognosis with resistance to chemotherapy or radiotherapy. Until now there is no standard third-line treatment for patients who have failed second-line therapy.

Patient Concerns: A 58-year-old non-smoking female peasant of ethnic Han was admitted to the oncology department of the 363 Hospital with a primary complaint of chest tightness and breathlessness from 3 months ago. Read More

QJM 2018 Nov 5. Epub 2018 Nov 5.

Advanced Eye Centre, Department of Ophthalmology, Post graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Cancer 2018 Dec 5;124(23):4548-4555. Epub 2018 Nov 5.

Department of Pediatrics, Masonic Children's Hospital, University of Minnesota Medical Center, Minneapolis, Minnesota.

Background: Axitinib is an oral small molecule that inhibits receptor tyrosine kinases vascular endothelial growth factor receptors 1 to 3. A phase 1 and pharmacokinetic (PK) trial evaluating axitinib was conducted in children with refractory solid tumors.

Methods: Axitinib was administered orally twice daily in continuous 28-day cycles. Read More