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Zhonghua Xin Xue Guan Bing Za Zhi 2020 May 26;48(0):E018. Epub 2020 May 26.

Administration Office, Shenzhen Third People's Hospitle, Shenzhen 518112, China.

To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of similar cases. Data of clinical manifestation, laboratory examination, bronchoscopy, echocardiography and cardiopulmonary pathological results were retrospectively reviewed in a case of COVID-19 with rapid exacerbation from mild to critical condition. This patient hospitalized at day 9 post 2019 novel coronavirus(2019-nCoV) infection, experienced progressive deterioration from mild to severe at day 11, severe to critical at day 18 and underwent extracorporeal membrane oxygenation(ECMO) and continuous renal replacement therapy(CRRT) as well as heart lung transplantation during day 28-45 day post infection, and died on the second day post heart and lung transplantation. Read More

Phytother Res 2020 May 25. Epub 2020 May 25.

Department of Pharmacology, College of Pharmacy, Ningxia Medical University, Yinchuan, China.

Pulmonary arterial hypertension (PAH) is a malignant disease with high mortality and closely involves the bone morphogenetic protein (BMP) pathway. Mutations in BMPR2 caused proliferation of pulmonary artery smooth muscle cells (PASMCs) leading to PAH. Isorhamnetin, one of the main naturally occurring flavonoids extracted from Hippophae rhamnoides L, shows antiinflammatory and anti-proliferative properties. Read More

Adv Clin Exp Med 2020 May 22. Epub 2020 May 22.

Institute of Medical Sciences, College of Medical Sciences, University of Rzeszów, Poland.

Background: Endometrial cancer is the most common malignant neoplasm of the female reproductive organs. A dysfunctional endometrial renin-angiotensin system (RAS) might contribute to the growth and spread of endometrial cancer. The RAS-related gene polymorphisms, including the polymorphism of insertion/deletion (I/D) in the angiotensin-converting enzyme (ACE) gene, influence RAS activity. Read More

Anasthesiol Intensivmed Notfallmed Schmerzther 2020 May 20;55(5):300-313. Epub 2020 May 20.

Drug-drug interactions are common problems in intensive care units. Numerous studies could demonstrate the impact of the total amount of prescribed drugs and the occurrence of potential respectively manifest drug-drug interactions in critically ill patients. The average number of clinically used drugs in this setting is approximately 25 - 35 per patient, thus the profound knowledge of pharmacodynamic and pharmakokinetic mechanisms regarding drug interplay is important for treatment safety. Read More

Front Nutr 2020 30;7:57. Epub 2020 Apr 30.

Department of Surgery Center, Fuchu Hospital, Osaka, Japan.

We report the successful management of stage III colon cancer in an elderly patient who received an adjuvant chemotherapy regimen of capecitabine plus oxaliplatin (CAPOX) with the Japanese kampo medicine ninjin'yoeito (NYT). A 75-year-old woman with a medical history of hypertension presented at another institution with fecal occult blood, and a colonoscopy that showed a type II tumor in the sigmoid colon. She was referred to our hospital for tumor resection, where colonoscopy confirmed the location of the type II tumor in the sigmoid colon. Read More

Thorac Cancer 2020 May 18. Epub 2020 May 18.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Pleurodesis is the standard of care for non-small cell lung cancer (NSCLC) patients with symptomatic malignant pleural effusion (MPE). However, there is no standard management for MPE uncontrolled by pleurodesis. Most patients with unsuccessful MPE control are unable to receive effective chemotherapy. Read More

World J Clin Cases 2020 May;8(9):1752-1755

Department of Urology, Beijing Hospital, Beijing 100730, China.

Lymphoepithelioma-like carcinoma (LELC) is a rare, malignant epithelial tumour which can arise within the upper urinary tract. This letter adds to a previous systematic review and cumulative analysis of 28 published upper urinary tract-LELC cases which provided insight into this disease; however, the current evidence does not provide clinicians with clear guidelines due to its rarity. Therefore, the aim was to report a new case of renal pelvis LELC presented in our hospital. Read More

Acta Haematol 2020 May 14:1-9. Epub 2020 May 14.

Department of Chemical Pathology, Guy's and St Thomas' and Lewisham and Greenwich Trust, London, United Kingdom,

Multiple myeloma (MM) is a haematological malignancy arising from monoclonal proliferation of plasma cells in the bone marrow, resulting in the presence of paraproteins or M-protein in serum. The involvement of paraproteins produced by malignant plasma cells in the development of hyperlipidaemia and low-HDL cholesterol has been described, as has an association with MM and obesity, hypertension, and type 2 diabetes mellitus, and insulin resistance, that is, features of the metabolic syndrome (MS). There is an association between MS components, inflammatory cytokines, and the development of MM, and some drugs used in the treatment of MS such as statins and metformin may improve outcomes in MM. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2020 May;54(5):534-538

Department of Chronic Non-communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.

To evaluate the correlation of community management index of essential hypertension and type 2 diabetes with the probability of premature mortality of major chronic diseases. From 2016 to 2018, the management of essential hypertension and type 2 diabetes were obtained from annual report of comprehensive prevention and control of chronic diseases in communities of Zhejiang province. The death data of chronic diseases were obtained from Information Management System of Chronic Diseases of Zhejiang province and annual population data were obtained from Public Security Bureau of Zhejiang Province. Read More

Med Oral Patol Oral Cir Bucal 2020 May 10. Epub 2020 May 10.

Department of Stomatology II University of the Basque Country (UPV/EHU) Barrio Sarriena sn. 48940. Leioa, Spain

Background: To clinicopathologically characterize the diagnosis of oral lichenoid disease (OLD) and its main subtypes: oral lichen planus (OLP) and oral lichenoid lesion (OLL), in order to correctly asses their prognosis.

Material And Methods: Ambispective cohort study of 384 patients with diagnosis of OLD, based on pre-established clinical and histopathological criteria. We have analysed 272 (70. Read More

Sci Rep 2020 May 6;10(1):7683. Epub 2020 May 6.

Monla Hospital, Tripoli, Lebanon.

Increased risk of comorbidities has been reported in Rheumatic and Musculoskeletal Diseases (RMD). We aimed to evaluate the prevalence and pattern of comorbidities in RMD patients nationwide, to identify multimorbidity clusters and to evaluate the gap between recommendations and real screening. Cross-sectional, multicentric nationwide study. Read More

Curr Med Res Opin 2020 May 15:1-7. Epub 2020 May 15.

BCN Health Economics & Outcomes Research S.L, Barcelona, Spain.

This study aimed to describe the current status of lung cancer in Spain, including patient characteristics and in-hospital mortality, and to revise disease management and the direct medical costs of secondary care. A retrospective observational study was set to analyse anonymized primary and secondary care records of patients admitted with lung cancer in Spain between 2011 and 2016. Data were obtained from the Primary Care Dataset and the Centralised Hospital Discharge Database. Read More

Eur Heart J Case Rep 2020 Apr 18;4(2):1-2. Epub 2020 Feb 18.

Department of Radiodiagnosis, Sri Aggarsain International Hospital, Sector 22, Rohini, New Delhi, Delhi 110086, India.

J Oncol Pharm Pract 2020 Apr 29:1078155220920684. Epub 2020 Apr 29.

Division of Medical Oncology, Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey.

Purpose: Malignant high-grade gliomas are the most common and aggressive type of primary brain tumor, and the prognosis is generally extremely poor. In this retrospective study, we analyzed the outcome of systemic treatment in recurrent high-grade glioma patients and the impact of prognostic factors on survivals.

Methods: Data from 114 patients with recurrent high-grade glioma who received systemic treatment and followed in our clinic between 2012 and 2018 were retrospectively analyzed. Read More

Cancer Cytopathol 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Background: The ThyroSeq panel tests for genetic alterations to risk-stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center.

Methods: Results from ThyroSeq testing (v2 and v3) were reviewed over 2 years, and patient demographics, cytology diagnoses, results of ThyroSeq testing, and histopathologic diagnoses on resection (if available) were collected. Read More

Nutr Cancer 2020 Apr 25:1-6. Epub 2020 Apr 25.

Department of Cardiology and Hypertension, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Preoperative assessment of patients is meaningful to predict survival in patients with malignant tumors. The prognostic nutritional index (PNI) is one of the most significant factors related to the prognosis in various types of cancer; however, its role in esophageal cancer is still inconclusive. The aim of this study was to identify the prognostic value of PNI in predicting overall survival (OS) in esophageal squamous cell carcinoma (ESCC). Read More

Vasc Health Risk Manag 2020 8;16:125-132. Epub 2020 Apr 8.

Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia.

Background: Risk stratification models with incorporation of biochemical markers have received attention recently. In acute myocardial infarction (AMI) one such marker is lipoprotein(a) (Lp(a)). Lp(a) has prothrombotic and proinflammatory properties. Read More

Bone Marrow Transplant 2020 Apr 18. Epub 2020 Apr 18.

Peking University People's Hospital, Beijing, China.

Posterior reversible encephalopathy syndrome (PRES) is a gradually recognised neurological complication of allogenic haematopoietic stem cell transplantation (allo-HSCT). However, there is a paucity of information on PRES after haploidentical HSCT (haplo-HSCT). We performed a retrospective nested case-control study in patients following haplo-HSCT for malignant and nonmalignant haematologic diseases between January 2009 and December 2018 in our centre. Read More

J Clin Hypertens (Greenwich) 2020 May 9;22(5):914-923. Epub 2020 Apr 9.

Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Hypertensive crises are associated with high rates of target organ complications and poor outcomes. A recent shift from the definition of malignant hypertension to hypertension-multiorgan damage (MOD) contributes to the diagnosis and management of hypertensive crises. Here, we prospectively included 166 adult (≥18 years old) patients with hypertensive crises (blood pressure >180/120 mm Hg). Read More

Case Rep Neurol 2020 Jan-Apr;12(1):63-68. Epub 2020 Feb 12.

Geisinger Health System, Danville, Pennsylvania, USA.

Posterior reversible encephalopathy syndrome (PRES) is a neurological syndrome characterized by an altered level of consciousness, headaches, seizure, and visual changes. PRES has several different etiologies, including malignant hypertension, eclampsia, and certain medications. Here, we describe a 41-year-old woman who presented with altered mental status. Read More

Cochrane Database Syst Rev 2020 03 30;3:CD012056. Epub 2020 Mar 30.

Birmingham Children's Hospital, Liver Unit, Steelhouse Lane, Birmingham, UK, B4 6NH.

Background: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes. In the liver this leads to focal biliary fibrosis resulting in progressive portal hypertension and end-stage liver disease in some individuals. This can be asymptomatic, but may lead to splenomegaly and hypersplenism, development of varices and variceal bleeding, and ascites; it has negative impact on overall nutritional status and respiratory function in this population. Read More

Curr Neurol Neurosci Rep 2020 Mar 26;20(4). Epub 2020 Mar 26.

Department of Neurology, Division of Neuro-Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Shapiro Building, 5th Floor, 330 Brookline Avenue, Boston, MA, 02215, USA.

Purpose Of Review: The goal of this review is to describe the presenting features of fulminant idiopathic intracranial hypertension (IIH) and outline the multimodal approach to its treatment.

Recent Findings: Venous sinus stenting may be an appropriate alternative to optic nerve sheath fenestration or cerebrospinal fluid shunting in select patients with fulminant IIH. Prompt surgical intervention maximizes the chance of visual recovery in patients with fulminant IIH. Read More

JAMA Cardiol 2020 Mar 27. Epub 2020 Mar 27.

Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Importance: Increasing numbers of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) are occurring in several countries and continents. Information regarding the impact of cardiovascular complication on fatal outcome is scarce.

Objective: To evaluate the association of underlying cardiovascular disease (CVD) and myocardial injury with fatal outcomes in patients with COVID-19. Read More

Cancer Manag Res 2020 13;12:1941-1946. Epub 2020 Mar 13.

Department of Cardiothoracic Surgery, People's Hospital of Chizhou, Chizhou, People's Republic of China.

Background: The most common cancer among humans is lung cancer. Non-small cell lung cancer (NSCLC) comprises the majority of these cases. In the development and progression of cancers across the spectrum, tumor abnormal protein (TAP) plays crucial roles. Read More

Cancer Biol Ther 2020 Mar 25:1-7. Epub 2020 Mar 25.

Department of Neurosurgery, Shandong Cancer Hospital Affiliated to Shandong University; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Up to now, no proven effective medical therapy for surgery and radiation-refractory anaplastic meningioma (AM) exists. Patients with vascular endothelial growth factor receptor 2 (VEGFR-2) positive meningiomas showed significantly shorter progression-free survival. Apatinib is a small-molecule antiangiogenic agent that selectively inhibits VEGFR-2. Read More

J Vasc Surg Venous Lymphat Disord 2020 Mar 20. Epub 2020 Mar 20.

Department of Medical Oncology, Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, China. Electronic address:

Objective: Peripherally inserted central venous catheter (PICC)-related thrombosis (PRT) is a serious complication that can lead to interruptions in chemotherapy and other supportive care, as well as increased hospital stay and costs. We conducted a retrospective study to evaluate the patterns of symptomatic PRT in patients with cancer undergoing chemotherapy and their risk factors.

Methods: A retrospective study of 938 PICC patients from our institution between November 2014 and July 2017 was performed. Read More

Korean J Radiol 2020 Apr;21(4):387-401

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Radiomics and deep learning have recently gained attention in the imaging assessment of various liver diseases. Recent research has demonstrated the potential utility of radiomics and deep learning in staging liver fibroses, detecting portal hypertension, characterizing focal hepatic lesions, prognosticating malignant hepatic tumors, and segmenting the liver and liver tumors. In this review, we outline the basic technical aspects of radiomics and deep learning and summarize recent investigations of the application of these techniques in liver disease. Read More

Chin Med J (Engl) 2020 Apr;133(8):975-981

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Background: Takayasu arteritis-induced renal arteritis (TARA), commonly seen in Takayasu arteritis (TA), has become one of the main causes of poor prognosis and early mortality in patients with TA. TARA progressing into Takayasu arteritis-induced renal artery stenosis (TARAS), could lead to severe complications including malignant hypertension, cardiac-cerebral vascular disease, and ischemic nephropathy. Since there existed no guidelines on treatments, this study aimed to review the comprehensive treatments for TARA. Read More

Gastroenterol Res Pract 2020 26;2020:9058909. Epub 2020 Feb 26.

Department of Emergency, Katip Celebi University Ataturk Training and Research Hospital, 35360 Izmir, Turkey.

Background: Portal hypertensive polyps in patients with portal hypertension are described.

Aims: The most significant and serious complication in liver cirrhosis proves to be portal hypertension. Polypoid lesions, which can be seen in the stomach as endoscopic finding in patients with portal hypertension, have not quite been defined in the literature. Read More

Wounds 2020 Mar;32(3):86-92

Adjunct Professor, University of Michigan, Ann Arbor, MI.

The lymphatic system is arguably the most neglected bodily system. As a result, its contribution to human health and disease is not well understood. In this review, the clinical approaches based on new knowledge and developments of the lymphatic system are covered. Read More

Nat Commun 2020 Mar 11;11(1):1310. Epub 2020 Mar 11.

Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. Read More

Fam Med Community Health 2019 30;7(4):e000180. Epub 2019 Oct 30.

Department of Clinical Oncology, National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.

Objective: To find an association between metabolic non-communicable disease (NCD) risk factors (high blood pressure (BP), high random blood sugar (RBS) and overweight /obesity) and oral, breast, cervical cancers/precancerous or potentially malignant conditions.

Design: This is an observational study using convenience sampling. The participants were screened through opportunistic or population-based screening. Read More

Zhonghua Nei Ke Za Zhi 2020 Mar;59(3):250-252

Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

The 21-year-old male patient was admitted to the Department of Rheumatology and Immunology at Peking Union Medical College Hospital with chief complaints of "skin rash for 1 year and edema for 2 months". He was diagnosed with systemic lupus erythematosus (SLE) with renal, cardiac and hematological involvement. Remission was not achieved after glucocorticoid pulse treatment. Read More

J Cardiovasc Pharmacol 2020 Mar 3. Epub 2020 Mar 3.

Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing, 100853, China.

Pulmonary arterial hypertension (PAH) is a progressive and malignant disease characterized by pulmonary small arteries and right ventricle (RV) remodeling that can lead to severe RV dysfunction and death. The current therapeutic targets for RV dysfunction, which is strongly linked to mortality, are far from adequate. Therefore, we investigated the effect of Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, on PAH-induced RV remodeling and its underlying mechanism. Read More

J Assoc Physicians India 2020 Mar;68(3):20-22

Professor and Head, Departments of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh; Corresponding Author.

Aim: To study the clinical profile and outcome of the patients with kidney biopsy diagnosis of IgA Nephropathy (IgAN).

Methods: A retrospective study of the patients diagnosed IgAN over a period of three and half years.

Results: Sixty (13. Read More

Eur Heart J Case Rep 2020 Feb 31;4(1):1-6. Epub 2019 Dec 31.

National Medical Research Center named after E.N. Meshalkin, Novosibirsk, Russian Federation.

Background: Isolated left ventricular apical hypoplasia (ILVAH) is a rare congenital cardiac abnormality, which might result in severe symptomatic heart failure (HF) with pulmonary hypertension, atrial fibrillation (AF), or malignant ventricular tachycardia in adults.

Case Summary: A 32-years-old man presented with exertional dyspnoea New York Heart Association Class II and persistent AF. Echocardiography and cardiac magnetic resonance showed the presence of (i) spherical remodelling of the left ventricle (LV) with impaired contractile function (three-dimensional ejection fraction, EF 32%); (ii) substitution of apical myocardium by fatty tissue; (iii) abnormal origin of a papillary muscle network; and (iv) an elongated right ventricle, compatible with ILVAH. Read More

Pediatr Neurol 2020 May 9;106:65-67. Epub 2020 Jan 9.

Department of Children's Neurosciences, Guys and St. Thomas' Hospital NHS Foundation Trust, Kings Health Partners, London, UK.

BMC Cardiovasc Disord 2020 Feb 27;20(1):95. Epub 2020 Feb 27.

Department of Cardiology, Zhongda Hospital affiliated to Southeast University, Nanjing, 210009, People's Republic of China.

Background: We aim to find out the relationship between random blood glucose (RBG), fasting blood glucose (FBG) and in-hospital adverse events in ST-segment elevation acute myocardial infarction (STEMI) patients. We evaluate and compare the predictive value of RBG and FBG on in-hospital adverse events, and give an appropriate cut-off value of RBG and FBG.

Method: A retrospective study enrolled 958 consecutive AMI patients undergoing emergency coronary angiography at Zhongda Hospital were enrolled from January 1, 2016, to December 31, 2018 was performed. Read More

Expert Opin Pharmacother 2020 Feb 26:1-4. Epub 2020 Feb 26.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.

: According to current guidelines, malignant hypertension is one of the emergencies in hypertension. The definition requires the presence of bilateral retinal hemorrhages or exudates, with or without papilledema, acute heart failure and acute deterioration in renal function in severe hypertension. Patients with malignant hypertension are characterized by pronounced target organ damage, including structural and functional cardiac abnormalities and renal insufficiency. Read More

Semin Diagn Pathol 2020 May 6;37(3):121-126. Epub 2020 Feb 6.

The University of Chicago, Department of Pathology, Chicago, IL 60637.

Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia and microangiopathic hemolytic anemia, results from acute and/or chronic endothelial cell injury, and often manifests with kidney dysfunction. TMA can be observed in a wide spectrum of clinical scenarios, which includes but is not limited to thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, severe (malignant) hypertension, preeclampsia/eclampsia, antiphospholipid antibody syndrome, scleroderma renal crisis, drug toxicities, or metabolic disorders. These different conditions are impossible to distinguish based solely on the pathologic findings, necessitating correlation with clinical and laboratory data. Read More

Clin Kidney J 2020 Feb 22;13(1):39-41. Epub 2019 Nov 22.

Nephrology Department, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Direct renin inhibitors (DRIs) block the activation of the alternative complement pathway and could be a treatment option for refractory hypertension in atypical hemolytic uremic syndrome (aHUS). A 20-year-old male presented with primary aHUS complicated by end-stage renal disease and refractory malignant hypertension despite being on five antihypertensive medications at maximum dose. Only a partial response was achieved with aliskiren and eculizumab, but after increasing aliskiren to a supratherapeutic dose, antihypertensive medication was reduced, platelets increased, C3 increased and epoetin alfa requirement decreased. Read More

Lancet Oncol 2020 Mar 14;21(3):456-466. Epub 2020 Feb 14.

Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori, Milan, Italy.

Background: Solitary fibrous tumour is an ultra-rare sarcoma, which encompasses different clinicopathological subgroups. The dedifferentiated subgroup shows an aggressive course with resistance to pazopanib, whereas in the malignant subgroup, pazopanib shows higher activity than in previous studies with chemotherapy. We designed a trial to test pazopanib activity in two different cohorts of solitary fibrous tumour: the malignant-dedifferentiated cohort, which was previously published, and the typical cohort, which is presented here. Read More

J Vasc Surg Venous Lymphat Disord 2020 Feb 14. Epub 2020 Feb 14.

Department of Pancreatitis Center, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address:

Objective: Lower extremity deep venous thrombosis (LEDVT) is common and can lead to pulmonary embolism (PE). Currently, the mechanism of how LEDVT causes PE is unclear. The aim of this study was to explore the relationship between the thrombus sites and PE in LEDVT patients. Read More

Am J Hypertens 2020 Apr;33(5):407-413

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.

Background: Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial fibrillation (AF) in hypertension. Thus, stabilizing RyR function with chronic dantrolene treatment may attenuate hypertension and AF inducibility in spontaneously hypertensive rats (SHR). Read More

Blood Adv 2020 Feb;4(3):530-538

Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL; and.

Ponatinib is associated with cardiovascular adverse events (CAEs), and its frequency in the real world is limited. In this retrospective study, we examined the survival outcomes and associated toxicities in 78 consecutive ponatinib-treated patients with chronic myeloid leukemia (CML) at the Moffitt Cancer Center from January 2011 through December 2017. The most common non-CAE was thrombocytopenia (39. Read More

Dermatol Online J 2019 12 15;25(12). Epub 2019 Dec 15.

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center Dermatology Residency Program, Largo, FL.

Angiosarcomas are malignant neoplasms arising from endothelial cells. Cutaneous angiosarcoma is the most common form, typically occurring in the setting of chronic lymphedema or previous radiation. The head and neck are the most common locations for cutaneous angiosarcoma, with rare occurrence on the trunk and extremities. Read More

BMC Infect Dis 2020 Feb 10;20(1):121. Epub 2020 Feb 10.

Hospital Infection Management Division, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: We analyzed the results of a 3-year surveillance study on the epidemiological and clinical characteristics of healthcare associated-infections (HAIs) in elderly inpatients in a large tertiary hospital in China.

Methods: Real-time surveillance was performed from January 1, 2015 to December 31, 2017. All HAIs were identified by infection control practitioners and doctors. Read More

Am J Hypertens 2020 Apr;33(4):303-304

Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.

J Clin Med 2020 Feb 3;9(2). Epub 2020 Feb 3.

Program of Cardiovascular and Renal Diseases, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.

In hypertensive patients with heart failure (HF) a serum biomarker combination of high carboxy-terminal propeptide of procollagen type-I (PICP) and low carboxy-terminal telopeptide of collagen type-I to matrix metalloproteinase-1 (CITP:MMP-1) ratio identifies a histomolecular phenotype of malignant myocardial fibrosis (mMF) associated with severe diastolic dysfunction (DD) and poor outcomes. As chronic kidney disease (CKD) facilitates MF and DD, we investigated the influence of CKD on the mMF biomarker combination in HF patients with preserved ejection fraction (HFpEF). Hypertensives ( = 365), 232 non-HF and 133 HFpEF, were studied, and 35% non-HF and 46% HFpEF patients had CKD (estimated glomerular filtration rate < 60 mL/min/1. Read More

Cureus 2019 Dec 30;11(12):e6514. Epub 2019 Dec 30.

Internal Medicine, AtlantiCare Regional Medical Center, Atlantic City, USA.

Angiosarcoma is a rare malignant neoplasm with a very poor prognosis that originates from the vascular endothelium and accounts for only 1%-2% of all sarcomatous malignancies. It is most commonly present in the deep soft tissues. Still, a wide range of primary sites, including the adrenals, thyroid, skin, and bone, are encountered. Read More