14,069 results match your criteria Hypertension[Journal]
Hypertension 2019 Jan;73(1):e8
Hypertension 2019 Jan;73(1):102-111
From the Department of Cardiology and Angiology, Hannover Medical School, Germany (D.F., S.T., D.H.-K., P.G., J.B.).
Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell-restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated with enhanced infarct neovascularization and scar maturation. Read More
Hypertension 2018 10 22;72(6):1365–1373. Epub 2018 Oct 22.
Department of Life, Health, and Environmental Sciences, San Salvatore Hospital, University of L’Aquila, Italy
Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown. We retrospectively analyzed cross-sectional, nationally representative data from treated hypertensive adults aged ≥30 years with and without periodontitis. Read More
Hypertension 2018 Nov;72(5):1078-1080
From the Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Australia (R.S.M., P.S., D.L.).
Hypertension 2018 Nov;72(5):1090-1092
Care Coordination Institute, Greenville, SC (B.M.E., C.R.).
Hypertension 2018 Nov;72(5):1084-1086
From the Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, and Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson.
Hypertension 2018 Nov;72(5):1087-1089
From the Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, United Kingdom.
Hypertension 2018 Nov;72(5):1081-1083
From the Department of Physiology, Augusta University, GA.
Hypertension 2018 Nov;72(5):1093-1094
From the Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.
Hypertension 2018 Nov;72(5):1076-1077
Sorbonne Paris Cité, CART, INSERM U965, Université Paris Diderot, France (N.K.).
Hypertension 2018 Nov;72(5):e53-e90
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic. The antihypertensive drugs should be administered at maximum or maximally tolerated daily doses. RH also includes patients whose BP achieves target values on ≥4 antihypertensive medications. Read More
Hypertension 2018 11;72(5):1037-1046
From the Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (P.C.D., R.N.L., D.W.D., N.O., B.A.K.).
Hypertension 2018 Nov;72(5):1060-1071
From the Department of Cardiovascular Medicine, Saga University, Japan (A.T., K.N.).
Hypertension 2018 Nov;72(5):1047-1059
From the Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, P.R. China (G.W., C.Z.).
Hypertension 2018 Nov;72(5):1023-1030
From the Divisions of Nephrology and Hypertension (A.E., S.C.T., L.O.L.), Mayo Clinic, Rochester, MN.
Hypertension 2018 Nov;72(5):1012-1022
From the KU Leuven Department of Cardiovascular Sciences, Research Unit Hypertension and Cardiovascular Epidemiology (Z.-Y.Z., J.A.S.), University of Leuven, Belgium.
Hypertension 2018 Nov;72(5):1031-1036
Department of Clinical Gene Therapy (R.M.), Graduate School of Medicine, Osaka University, Japan.
Hypertension 2018 Nov;72(5):1072-1075
Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.M.T.).
Hypertension 2018 Nov;72(5):1103-1108
From the Department of Population Science and Experimental Medicine, Institute of Cardiovascular Sciences, University College London, United Kingdom (C.P., S.J., N.C., A.D.H.).
Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)-a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)-a prospective population-based birth cohort study. Read More
Hypertension 2018 Nov;72(5):e43-e52
From the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (R.F., H.G., J.J.G., G.D.F., H.X.).
We examined the impact of sex on high-fat diet (HFD)-induced renal alterations in Dahl salt-sensitive and Sprague Dawley rats. In Dahl rats, HFD (60% kcal from fat for 24-26 weeks starting at weaning) significantly and equally increased blood pressure in males and females when compared with rats fed a control diet (10% kcal from fat). Male Dahl rats on HFD exhibited progressive renal histological injury and moderately increased renal macrophage infiltration at 10 and 24 weeks of feeding when compared with males on control diet. Read More
Hypertension 2018 Nov;72(5):1189-1199
Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China (H.W., J.-n.Z., F.Z., Y.M., X.-m.C., W.-d.Q.).
Abdominal aortic aneurysm (AAA) is a common vascular degenerative disease. PARP-1 (poly[ADP-ribose] polymerase 1) is a nuclear enzyme, which plays a critical role in vascular diseases. We hypothesized that PARP-1 inhibition might have protective effects on AAA. Read More
Hypertension 2018 Nov;72(5):1117-1124
From the Unit of PharmacoTherapy, -Epidemiology, and -Economics, Department of Pharmacy, University of Groningen, The Netherlands (A.V.v.S., A.D.I.v.A., M.J.P.).
Nonadherence to antihypertensive medications is known to be a major health problem. Novel biochemical analyses using liquid chromatography-tandem mass spectrometry are becoming accepted as a clinically useful objective measure to manage (non)adherence in Hypertension Clinics. Discussion of results from such analyses with patients can significantly improve adherence and blood pressure control. Read More
Hypertension 2018 Nov;72(5):1141-1150
Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.).
Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models of hypertension and hypertensive patients. We have shown that gut dysbiosis plays a causal role in the development of hypertension in a rat model of obstructive sleep apnea (OSA). Functional analysis of the dysbiotic microbiota in OSA demonstrates a loss of short chain fatty acid-producing bacteria. Read More
Hypertension 2018 Nov;72(5):1160-1171
Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee (P.L., Y. Liu, X.P., Y. Li, K.U., M.K.M., M.L.).
Numerous adult diseases involving tissues consisting primarily of nondividing cells are associated with changes in DNA methylation. It suggests a pathophysiological role for de novo methylation or demethylation of DNA, which is catalyzed by DNA methyltransferase 3 and ten-eleven translocases. However, the contribution of DNA de novo (de)methylation to these diseases remains almost completely unproven. Read More
Hypertension 2018 Nov;72(5):1095-1102
From the Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France (T.T.v.S., P.B., Q.L., M.T., C.G., R.E.C., J.E.S., S.L., X.J., J.-P.E.).
Vascular aging is a major contributor to cardiovascular disease and can be quantified by higher carotid stiffness, intima-media thickness and diameter, and hypertension. Weight gain across the lifetime may be an important, modifiable determinant of vascular aging. We therefore aimed to assess lifetime body silhouette trajectories (a marker of weight change across the lifespan) in relation to vascular aging in late adulthood. Read More
Hypertension 2018 Nov;72(5):1151-1159
Department of Nephrology, Saitama Medical University, Iruma, Japan (T.I., T.M., H.S.).
Renal expression of klotho is reduced in hypertension. Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensive rats (sp-SHR). The interactions between klotho protein and renal renin-Ang (angiotensin) system were examined with immunoprecipitation and cell culture methods. Read More
Hypertension 2018 Nov;72(5):1200-1207
From Department of Medicine, Columbia University Medical Center, New York, NY (D.E.A, N.A.B, D.N.P, I.M.K., J.E.S., D.S.).
Guidelines recommend measuring out-of-clinic blood pressure (BP) to identify masked hypertension (MHT) defined by out-of-clinic BP in the hypertensive range among individuals with clinic-measured BP not in the hypertensive range. The aim of this study was to determine the overlap between ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) for the detection of MHT. We analyzed data from 333 community-dwelling adults not taking antihypertensive medication with clinic BP <140/90 mm Hg in the IDH study (Improving the Detection of Hypertension). Read More
Hypertension 2018 Nov;72(5):1125-1132
From the Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, OH (H.W., X.C., S.G., B.M., G.V., M.V.K., B.J.).
G-protein-coupled estrogen receptor, Gper1, has been implicated in cardiovascular disease, but its mechanistic role in blood pressure control is poorly understood. Here, we demonstrate that genetically salt-sensitive hypertensive rats with complete genomic excision of Gper1 by a multiplexed guide RNA CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR associated proteins) approach present with lower blood pressure, which was accompanied by altered microbiota, different levels of circulating short chain fatty acids, and improved vascular relaxation. Microbiotal transplantation from hypertensive Gper1 rats reversed the cardiovascular protective effect exerted by the genomic deletion of Gper1. Read More
Hypertension 2018 Nov;72(5):1227-1235
From the Department of Pharmacology, UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa.
Low-salt diet is beneficial in salt-sensitive hypertension but may provoke cardiovascular risk in patients with heart failure, diabetes mellitus, or other cardiovascular abnormalities because of endogenous renin-angiotensin system activation. PPAR (peroxisome proliferator-activated receptor)-γ is a transcription factor which promotes an antioxidant pathway in the endothelium. We studied transgenic mice expressing a dominant-negative mutation in PPAR-γ selectively in the endothelium (E-V290M) to test the hypothesis that endothelial PPAR-γ plays a protective role in response to low salt-mediated renin-angiotensin system activation. Read More
Hypertension 2018 Nov;72(5):1217-1226
From the Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, QC, Canada.
The angiotensin receptor blocker losartan mitigated cerebrovascular and cognitive deficits in mouse models of Alzheimer disease, in line with some clinical evidence of reduced onset and progression to Alzheimer disease. We investigated whether these benefits apply to another angiotensin receptor blocker, namely candesartan. Adult transgenic mice overexpressing a mutated form of the human APP (amyloid precursor protein) and wild-type controls were treated with vehicle or candesartan (cohort 1: 2 months, 1 mg/kg per day, osmotic subcutaneous minipumps; cohort 2: 5 months, 10 mg/kg per day in drinking water). Read More
Hypertension 2018 Nov;72(5):1208-1216
From the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
High salt, Ang II (angiotensin II), and reactive oxygen species enhance progression of chronic kidney disease. We tested the hypothesis that a high salt intake generates specific reactive oxygen species to enhance Ang II contractions of afferent arterioles from mice with reduced renal mass (RRM). C57BL/6 mice were subjected to surgical RRM or sham operations and received 6% or 0. Read More
Hypertension 2018 Nov;72(5):1172-1179
From the Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.-Z.Z., S.W., Y.W., Y.Z., R.C.H.).
COX (cyclooxygenase)-derived prostaglandins regulate renal hemodynamics and salt and water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition, chronic analgesic abuse can induce renal injury, including papillary necrosis. Read More
Hypertension 2018 Nov;72(5):1133-1140
From the Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Japan (N.S.).
Research suggests that oxygen desaturation and sleep stage during obstructive sleep apnea (OSA) are related to the magnitude of high blood pressure (BP) in a laboratory setting. However, in a clinical setting, these associations have not been well studied. We used a noninvasive oscillometric BP measurement device to investigate the association between oxygen-triggered BP levels at the end of each OSA episode and the characteristics of the preceding OSA episode. Read More
Hypertension 2018 Nov;72(5):1180-1188
From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (I.O.S., A.S., A.A., A.E., C.M.F., J.R.W., S.C.T., A.S.P., L.O.L.).
Hypertension, an important cause of chronic kidney disease, is characterized by peritubular capillary (PTC) loss. Circulating levels of endothelial microparticles (EMPs) reflect systemic endothelial injury. We hypothesized that systemic and urinary PTC-EMPs levels would reflect renal microvascular injury in hypertensive patients. Read More
Hypertension 2018 Nov;72(5):1109-1116
From the EA 4468, Université Paris Descartes, Sorbonne Paris Cité, France (L.R., H.B., M.B., A.C., D.D., I.H., M.-L.S., J.-S.V., O.H.).
To investigate the association between pulse wave velocity, intima-media thickness, carotid artery diameter, carotid plaques, and conversion from mild cognitive impairment to dementia. Three hundred and seventy-five elderly ambulatory subjects with mild cognitive impairment were followed yearly to examine potential conversion to dementia. Vascular function was assessed by carotid-femoral pulse wave velocity. Read More
Hypertension 2018 Nov;72(5):1236-1242
From the Department of Anesthesiology, Mayo Clinic, Rochester, MN.
Autonomic support of blood pressure increases with age in humans. Large differences exist in the dose of trimethaphan (TMP) required for ganglionic blockade in young and older women. We asked whether differences in the dose of TMP required to achieve ganglionic blockade are because of differences in the relative contributions of the sympathetic and parasympathetic nervous system in control of blood pressure with age. Read More
Hypertension 2018 Sep;72(3):e37-e38
Hypertension 2018 Sep;72(3):588-591
From the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Hypertension 2018 Sep;72(3):592-593
From the Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Brazil.
Hypertension 2018 Sep;72(3):e34
Hypertension 2018 Sep;72(3):e36
Hypertension 2018 Sep;72(3):e31
Hypertension 2018 Sep;72(3):e35
Hypertension 2018 Sep;72(3):e30
Hypertension 2018 Sep;72(3):e33