14,243 results match your criteria Hypertension[Journal]


In Memoriam for Gerald Berenson.

Hypertension 2019 May;73(5):936-937

Centre for Population Health Research, University of Turku and Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, the i3C Research Group.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12474DOI Listing
May 2019
2 Reads

Role of Complement-Related Inflammation and Vascular Dysfunction in Hypertension.

Hypertension 2019 May;73(5):965-971

From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension at Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11210DOI Listing

Chronic Estrogen Supplementation Prevents the Increase in Blood Pressure in Female Intrauterine Growth-Restricted Offspring at 12 Months of Age.

Hypertension 2019 May;73(5):1128-1136

From the Department of Physiology and Biophysics (G.K.D., A.D.N., A.B.C., B.T.A.), University of Mississippi Medical Center, Jackson.

Low birth weight is associated with a greater prevalence of hypertension and an earlier age at menopause in women in later life. Yet, the association between birth weight and blood pressure (BP) in women as they age is not well defined. In a rodent model of low birth weight induced by placental insufficiency, intrauterine growth restriction programs a significant increase in BP by 12 months of age in female growth-restricted offspring that is associated with early reproductive senescence, increased testosterone, and a shift in the hormonal milieu. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458065PMC

Rising Pressure Pulsatility After Midlife in Women.

Authors:
Gary F Mitchell

Hypertension 2019 May;73(5):980-982

From the Cardiovascular Engineering, Inc, Norwood, MA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12501DOI Listing

Improving Hypertension Outcome Measurement in Low- and Middle-Income Countries.

Hypertension 2019 May;73(5):990-997

FHI360, London School of Hygiene & Tropical Medicine (P.L.).

High blood pressure is the leading modifiable risk factor for mortality, accounting for nearly 1 in 5 deaths worldwide and 1 in 11 in low-income countries. Hypertension control remains a challenge, especially in low-resource settings. One approach to improvement is the prioritization of patient-centered care. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11916DOI Listing
May 2019
3 Reads

Aligning Adult and Pediatric Blood Pressure Guidelines.

Hypertension 2019 May;73(5):938-943

University of Maryland School of Medicine, Baltimore (C.B.-S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12653DOI Listing
May 2019
1 Read

Hemodynamic Mechanism of the Age-Related Increase in Pulse Pressure in Women.

Hypertension 2019 May;73(5):1018-1024

From the British Heart Foundation Centre (Y.L., B.J., L.K., H.G., A.B., M.C., S.V., P.C.), King's College London, UK.

We examined the influence of arterial stiffening and ventricular ejection dynamics on the age-related increase in central pulse pressure. A total of 2033 women aged 18 to 91 years from the Twins UK cohort were studied. Aortic flow and central blood pressure were measured by Doppler sonography and carotid tonometry, respectively. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12402DOI Listing
May 2019
1 Read

Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia.

Hypertension 2019 May;73(5):1112-1119

From the Nuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom (M.G., C.M.-M., N.K., W.C., W.Z., A.S.C., C.R., M.V.).

NEP (neprilysin) is a widely expressed membrane-bound metalloprotease, which binds and cleaves a variety of peptides including vasodilators, natriuretics, and diuretics. Higher levels of NEP result in hypertension-a cardinal feature of the placental disease preeclampsia. Syncytiotrophoblast-derived extracellular vesicles (EVs), comprising microvesicles and exosomes, are released into the peripheral circulation in pregnancy and are postulated as a key mechanism coupling placental dysfunction and maternal phenotype in preeclampsia. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12707DOI Listing
May 2019
4 Reads
6.480 Impact Factor

miR-431-5p Knockdown Protects Against Angiotensin II-Induced Hypertension and Vascular Injury.

Hypertension 2019 May;73(5):1007-1017

From the Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research (K.-G.H., O.B., N.M., J.C.F.-A., T.B., S.O., S.C.C., P.P., E.L.S.), McGill University, Montreal, Quebec, Canada.

Vascular injury is an early manifestation in hypertension and a cause of end-organ damage. MicroRNAs play an important role in cardiovascular disease, but their implication in vascular injury in hypertension remains unclear. This study revealed using an unbiased approach, microRNA and mRNA sequencing with molecular interaction analysis, a microRNA-transcription factor coregulatory network involved in vascular injury in mice made hypertensive by 14-day Ang II (angiotensin II) infusion. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12619DOI Listing

MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)-induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c).

Hypertension 2019 May;73(5):e14-e24

From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.

Regulatory T cells (T cells) play important roles in hypertension and organ damages. MicroRNA-31 (miR-31) is a critical regulator for T cell generation. However, the role of miR-31 in hypertension has not been elucidated. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12319DOI Listing
May 2019
1 Read

Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure.

Hypertension 2019 May;73(5):1042-1048

Department of Laboratory Medicine, University of California, San Francisco (T.W.K.).

To reduce the risk of salt-induced hypertension, medical authorities have emphasized dietary guidelines promoting high intakes of potassium and low intakes of salt that provide molar ratios of potassium to salt of ≥1:1. However, during the past several decades, relatively few people have changed their eating habits sufficiently to reach the recommended dietary goals for salt and potassium. Thus, new strategies that reduce the risk of salt-induced hypertension without requiring major changes in dietary habits would be of considerable medical interest. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458074PMC

Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults.

Hypertension 2019 May;73(5):1025-1035

From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.).

Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age: 19-73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12462DOI Listing

Precarious Symbiosis Between Host and Microbiome in Cardiovascular Health.

Hypertension 2019 May;73(5):926-935

From the Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Germany (H.B., L.M., N.W., F.C.L., S.K.F., D.N.M.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.11786DOI Listing
May 2019
3 Reads

Shear-Sensitive lncRNA AF131217.1 Inhibits Inflammation in HUVECs via Regulation of KLF4.

Hypertension 2019 May;73(5):e25-e34

Cardiovascular Disease Center, The First Hospital of Jilin University, Changchun, Jilin, China (B.L.).

Atherosclerosis is one of the most common vascular diseases, and inflammation participates in all stages of its progression. Laminar shear stress protects arteries from atherosclerosis and reduces endothelial inflammation. Long noncoding RNAs have emerged as critical regulators in many diseases, including atherosclerosis. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12476DOI Listing
May 2019
2 Reads

Drug-Resistant Hypertension.

Hypertension 2019 May;73(5):920-925

From the Hypertension Unit, Department of Medicine (G.M., G.P.R.), University of Padua, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12068DOI Listing
May 2019
2 Reads

Brachial and Radial Systolic Blood Pressure Are Not the Same.

Hypertension 2019 May;73(5):1036-1041

From the Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (M.K.A., M.G.S., D.S.P., J.E.S.).

Radial intra-arterial blood pressure (BP) is sometimes used as the reference standard for validation of brachial cuff BP devices. Moreover, there is an emerging wearables market seeking to measure BP at the wrist. However, radial systolic BP may differ when compared with brachial; yet some authors have labeled these differences as a fictional Popeye phenomenon. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12674DOI Listing
May 2019
13 Reads

Pressure From the Bugs Within.

Hypertension 2019 May;73(5):977-979

Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, OH (S.C., M.V.-K., B.J.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12685DOI Listing
May 2019
1 Read
6.480 Impact Factor

Gut Microbiota Composition and Blood Pressure.

Hypertension 2019 May;73(5):998-1006

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC (A.L., K.A.M.).

Animal models support a role for the gut microbiota in the development of hypertension. There has been a lack of epidemiological cohort studies to confirm these findings in human populations. We examined cross-sectional associations between measures of gut microbial diversity and taxonomic composition and blood pressure (BP) in 529 participants of the biracial (black and white) CARDIA study (Coronary Artery Risk Development in Young Adults). Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458072PMC

Sympathetic System-Related Artery Stiffness.

Hypertension 2019 May;73(5):975-976

From the First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12571DOI Listing
May 2019
2 Reads

Evidence Supporting the Blood Pressure Treatment Goal of Less Than 130/80 mm Hg.

Hypertension 2019 May;73(5):972-974

Departments of Epidemiology and Medicine, Tulane University, New Orleans, LA (P.K.W.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12804DOI Listing

Retinoic Acid Is a Negative Regulator of sFLT1 Expression in Decidual Stromal Cells, and Its Levels Are Reduced in Preeclamptic Decidua.

Hypertension 2019 May;73(5):1104-1111

From the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA (V.D., M.B.S., M.L.B., N.S., A.R.).

sFLT1 (soluble VEGF [vascular endothelial growth factor] receptor-1) levels are increased in preeclampsia-a pathological condition of pregnancy. The mechanism of sFLT1 overexpression by gestational tissues, particularly the decidua, remains unknown. Mass spectrometry measurement of the active retinoid metabolite, all-trans retinoic acid (RA), showed significantly lower levels of RA in preeclamptic versus normotensive decidua. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12564DOI Listing
May 2019
1 Read

Role of Coronary Artery Calcium for Stratifying Cardiovascular Risk in Adults With Hypertension.

Hypertension 2019 May;73(5):983-989

Aetna Foundation, Hartford, CT (G.G.).

We examined the utility of coronary artery calcium (CAC) for cardiovascular risk stratification among hypertensive adults, including those fitting eligibility for SPRINT (Systolic Blood Pressure Intervention Trial). Additionally, we used CAC to identify hypertensive adults with cardiovascular disease (CVD) mortality rates equivalent to those observed in SPRINT who may, therefore, benefit from the most intensive blood pressure therapy. Our study population included 16 167 hypertensive patients from the CAC Consortium, among whom 6375 constituted a "SPRINT-like" population. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458064PMC
May 2019
2 Reads

Effect of a Walnut Diet on Office and 24-Hour Ambulatory Blood Pressure in Elderly Individuals.

Hypertension 2019 May;73(5):1049-1057

From the Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain (M.D., M.S.-M., I.R., T.F.-S., C.V.-P., M.C., A.L., A.S.-V., C.C., E.R.).

Nut consumption lowers blood cholesterol and is associated with reduced cardiovascular disease, but effects on blood pressure (BP) are inconsistent. We assessed the 2-year effects of a walnut diet versus a control diet on office BP and 24-hours ambulatory BP in free-living elders participating in the Walnuts and Healthy Aging study, a randomized trial testing the effects of walnuts at ≈15% energy on age-related disorders. In a prespecified analysis, we enrolled 305 participants, of whom 236 (75%) completed the study (65% women; age, 69 years; 60% with mild hypertension). Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12766DOI Listing
May 2019
1 Read

Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome.

Hypertension 2019 May;73(5):1087-1096

Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center (K.S., S.R.R., D.R., I.B., A.D.), Vanderbilt University School of Medicine, Nashville, TN.

The diagnosis of neuropathic postural tachycardia syndrome (POTS) requires research techniques not available clinically. We hypothesized that these patients will have impaired vagal and sympathetic cardiovascular control that can be characterized with clinical autonomic tests. We included 12 POTS patients with possible neuropathic subtype because of normal plasma norepinephrine and no increase in upright blood pressure. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11803DOI Listing
May 2019
6.480 Impact Factor

Renal Inflammation in DOCA-Salt Hypertension.

Hypertension 2019 May;73(5):1079-1086

From the Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (C.T.B., M.M.G., D.A.V.H., J.W.O.).

Recent reports indicate that, in addition to treating hypertension, renal denervation (RDN) also mitigates renal inflammation. However, because RDN decreases renal perfusion pressure, it is unclear whether these effects are because of the direct effects of RDN on inflammatory signaling or secondary to decreased arterial pressure (AP). Therefore, this study was conducted to elucidate the contribution of renal nerves to renal inflammation in the deoxycorticosterone (DOCA)-salt rat, a model in which RDN decreases AP and abolishes renal inflammation. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12762DOI Listing

Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Hypertension 2019 Mar 14:HYP0000000000000090. Epub 2019 Mar 14.

Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Read More

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http://dx.doi.org/10.1161/HYP.0000000000000090DOI Listing
March 2019
5 Reads
6.480 Impact Factor

Glaucoma and Blood Pressure.

Hypertension 2019 May;73(5):944-950

Department of Ophthalmology, Ghent University, Belgium; on behalf of the Belgian Glaucoma Society (P.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11507DOI Listing

Arterial Tortuosity.

Hypertension 2019 May;73(5):951-960

Division of Cardiology, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique (A.P.), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11647DOI Listing
May 2019
1 Read

Ambulatory Blood Pressure Measurement in the Elderly.

Hypertension 2019 May;73(5):961-964

From the Conway Institute, University College Dublin, Ireland (E.O.); and Department of Geriatric Medicine, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11977DOI Listing

Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.

Hypertension 2019 Apr;73(4):849-858

From the Diabetes and Cardiovascular Center (A.R.A., J.H., R.N., J.R.S., G.J., A.W.-C.).

Obesity is characterized by enhanced MR (mineralocorticoid receptor) activation, vascular stiffness, and associated cardiovascular and kidney disease. Consumption of a Western-style diet (WD), high in saturated fat and refined carbohydrates, by female mice, leads to obesity and vascular stiffening. Use of ECMR (endothelial cell-specific MR) knockout mice supports that ECMR activation is critical for development of vascular and cardiac fibrosis and stiffening. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448566PMC
April 2019
10 Reads

Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats.

Hypertension 2019 May;73(5):1120-1127

Department of Pharmacology and Toxicology (M.R.G., J.M.S.), University of Mississippi Medical Center, Jackson.

Fetal growth restriction (FGR) is associated with increased risk for cardiovascular and renal disorders in later life. Prenatal sildenafil improves birth weight in FGR animal models. Whether sildenafil treatment protects against long-term cardiovascular and renal disease in these offspring is unknown. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458081PMC
May 2019
3 Reads

HIMF (Hypoxia-Induced Mitogenic Factor)-IL (Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis.

Hypertension 2019 May;73(5):1058-1070

From the Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Pathophysiology (S.K., G.W., W.C., J.L.), Shenzhen University Health Science Center, China.

HIMF (hypoxia-induced mitogenic factor) is a secreted proinflammatory cytokine with a critical role in cardiac hypertrophy development. Loss of HIMF attenuates transverse aortic constriction-induced cardiac hypertrophy and fibrosis, but the underlying mechanisms are unknown. We show that IL (interleukin)-6 production increases following transverse aortic constriction in wild-type mice; this effect is inhibited in HIMF gene knockout ( Himf) mice. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12267DOI Listing
May 2019
3 Reads

Sudden Cardiac Death in Hypertensive Patients.

Hypertension 2019 May;73(5):1071-1078

Department of Medicine, University of Perugia, Italy (M.D.F., G.R.).

In patients with hypertension, but without established cardiovascular disease, predictive factors for sudden cardiac death (SCD) remain undefined. We followed for an average of 10.3 years a cohort of 3242 initially untreated hypertensive patients without evidence of coronary or cerebrovascular heart disease at entry. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12684DOI Listing
May 2019
6 Reads

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women.

Hypertension 2019 May;73(5):1097-1103

Department of Women's and Children's Health, Uppsala University, Sweden (R.H., L.B., A.W., A.-K.W., S.H.).

Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and neonatal morbidity and mortality. The only definite treatment is delivery. Preclinical investigations have identified proton pump inhibitors (PPIs), which are commonly used to treat reflux during pregnancy, as a potential treatment for preeclampsia. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12547DOI Listing
May 2019
2 Reads

Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association.

Hypertension 2019 May;73(5):e35-e66

The accurate measurement of blood pressure (BP) is essential for the diagnosis and management of hypertension. This article provides an updated American Heart Association scientific statement on BP measurement in humans. In the office setting, many oscillometric devices have been validated that allow accurate BP measurement while reducing human errors associated with the auscultatory approach. Read More

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http://dx.doi.org/10.1161/HYP.0000000000000087DOI Listing

Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide.

Hypertension 2019 Apr;73(4):900-909

From the Cardiorenal Research Laboratory (L.M.G.M., I.A.A., S.P., G.H., Y.C., Y.Z., G.E.H., T.I., D.M.H., S.R.I., S.J.S., J.C.B.), Mayo Clinic, Rochester, MN.

Despite optimal current therapies, cardiovascular disease remains the leading cause for death worldwide. Importantly, advances in peptide engineering have accelerated the development of innovative therapeutics for diverse human disease states. Additionally, the advancement of bispecific therapeutics targeting >1 signaling pathway represents a highly innovative strategy for the treatment of cardiovascular disease. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12012DOI Listing
April 2019
6.480 Impact Factor

Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.

Hypertension 2019 Apr;73(4):878-884

From the Departments of Nephrology (M.S., T.C., E.H., A.G., T.W., I.F.S.), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.

Endothelial dysfunction because of nitric oxide inactivation has been suggested to play a role in the pathogenesis of preeclampsia. During pregnancy, L-arginine transport by CAT-1 (cationic amino acid transporter 1), the only transporter for eNOS (endothelial nitric oxide synthase) is inhibited. We hypothesize that maternal arginine deficiency contributes to the development of preeclampsia. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12372DOI Listing
April 2019
5 Reads

Alpha-Synuclein Deposition Within Sympathetic Noradrenergic Neurons Is Associated With Myocardial Noradrenergic Deficiency in Neurogenic Orthostatic Hypotension.

Hypertension 2019 Apr;73(4):910-918

From the Autonomic Medicine Section (formerly Clinical Neurocardiology Section), Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (R.I., P.S., A.C., C.H., D.S.G.).

Lewy body diseases involve neurogenic orthostatic hypotension (nOH), cardiac noradrenergic deficiency, and deposition of the protein AS (alpha-synuclein) in sympathetic ganglion tissue. Mechanisms linking these abnormalities are poorly understood. One link may be AS deposition within sympathetic neurons. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472912PMC

Angiogenic Factor Estimation as a Warning Sign of Preeclampsia-Related Peripartum Morbidity Among Hospitalized Patients.

Hypertension 2019 Apr;73(4):868-877

From the Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (J.L.P., S.C., A.M., R.M., H.R., R.N., H.N., D.Y., S.S., S.R.), University of Chicago, IL.

Preeclampsia-related morbidity and mortality is rising predominantly because of delayed identification of patients at risk for preeclampsia with severe features and associated complications. This study explored the association between angiogenic markers (sFlt1 [soluble fms-like tyrosine kinase-1]) and PlGF [placental growth factor]) and preeclampsia-related peripartum complications. Normotensive women or those with hypertensive disorders of pregnancy were enrolled. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12205DOI Listing
April 2019
6 Reads
6.480 Impact Factor

Productivity Burden of Hypertension in Australia.

Hypertension 2019 Apr;73(4):777-784

From the Division of Clinical Epidemiology, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia (T.R.H., E.Z., A.J.O., D.J.M., D.L., Z.A.).

Hypertension increases the risk of premature death and reduces work productivity. We estimated the burden of hypertension in Australia in terms of productivity lost over the working lifetime of the Australian population. Life table models were used to estimate excess mortality, years of life lost, and productivity-adjusted life years lost among Australians with hypertension and of working age (20 to 69 years), with simulated follow-up until age 70 years. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12606DOI Listing
April 2019
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Effect of Morning Exercise With or Without Breaks in Prolonged Sitting on Blood Pressure in Older Overweight/Obese Adults.

Hypertension 2019 Apr;73(4):859-867

From the School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth (M.J.W., D.W.D., L.H.N., D.J.G.).

Both exercise and breaks in prolonged sitting can reduce blood pressure (BP) in older overweight/obese adults. We investigated whether there is an additive hypotensive effect when exercise is combined with subsequent breaks in sitting. Sex differences and changes in plasma catecholamines as a potential candidate mechanism underlying BP responses were also examined. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12373DOI Listing
April 2019
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Markers or Makers: Inflammatory Cytokines in Treatment-Resistant Hypertension

Hypertension 2019 04;73(4):767-769

From the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416056PMC

Aging, Arterial Stiffness, and Blood Pressure Association in Chinese Adults.

Hypertension 2019 Apr;73(4):893-899

Department of Nutritional Sciences, Pennsylvania State University, State College (X. Zhang, X.G.).

Arterial stiffness and blood pressure (BP) both increase with aging synchronously. Whether elevated BP results from thickening of arterial wall or vice versa is controversial in previous studies. This study included 17 862 participants without history of myocardial infarction, stroke, atrial fibrillation or flutter, or cancer and with brachial-ankle pulse wave velocity (baPWV) and BP measurements during 2010 to 2016. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12396DOI Listing
April 2019
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Hypertension Development by Midlife and the Roles of Premorbid Cognitive Function, Sex, and Their Interaction.

Hypertension 2019 Apr;73(4):812-819

From the Department of Psychology (D.M.A., C.W., I.J.D.), University of Edinburgh, United Kingdom.

Higher early-life cognitive function is associated with better later-life health outcomes, including hypertension. Associations between higher prior cognitive function and less hypertension persist even when accounting for socioeconomic status, but socioeconomic status-hypertension gradients are more pronounced in women. We predicted that differences in hypertension development between sexes might be associated with cognitive function and its interaction with sex, such that higher early-life cognitive function would be associated with lower hypertension risk more in women than in men. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426348PMC
April 2019
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Apneic Sleep, Insufficient Sleep, and Hypertension.

Hypertension 2019 Apr;73(4):744-756

Department of Cardiovascular Diseases (N.C., V.K.S.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11780DOI Listing

Inflammation and Apparent Treatment-Resistant Hypertension in Patients With Chronic Kidney Disease.

Hypertension 2019 Apr;73(4):785-793

From the Department of Medicine (J.C., L.L.H., J.H.), Tulane University School of Medicine, New Orleans, LA.

Apparent treatment-resistant hypertension (ATRH) is highly prevalent and associated with cardiovascular disease risk in patients with chronic kidney disease. We analyzed the association of inflammatory biomarkers with ATRH and its complications in patients with chronic kidney disease. ATRH was defined as blood pressure ≥140/90 mm Hg while taking ≥3 antihypertensive medications or blood pressure <140/90 mm Hg while taking ≥4 medications. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416070PMC

Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females: The Enigma Study

Hypertension 2018 Dec 15;72(6):1277-1284. Epub 2018 Oct 15.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom

Blood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221425PMC
December 2018
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Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan)

Hypertension 2019 Jan 19;73(1):52-59. Epub 2018 Nov 19.

Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo

Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11635DOI Listing
January 2019
11 Reads