14,069 results match your criteria Hypertension[Journal]


Clinical Implications.

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Hypertension 2018 Jul;72(1)

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Clinical Implications.

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Hypertension 2018 Mar;71(3):367

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Clinical Implications.

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Hypertension 2019 Jan;73(1)

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January 2019

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing.

Hypertension 2019 Jan;73(1):102-111

From the Department of Cardiology and Angiology, Hannover Medical School, Germany (D.F., S.T., D.H.-K., P.G., J.B.).

Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell-restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated with enhanced infarct neovascularization and scar maturation. Read More

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January 2019

Poor Oral Health and Blood Pressure Control Among US Hypertensive Adults: Results From the National Health and Nutrition Examination Survey 2009 to 2014

Hypertension 2018 10 22;72(6):1365–1373. Epub 2018 Oct 22.

Department of Life, Health, and Environmental Sciences, San Salvatore Hospital, University of L’Aquila, Italy

Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown. We retrospectively analyzed cross-sectional, nationally representative data from treated hypertensive adults aged ≥30 years with and without periodontitis. Read More

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October 2018

Clinical Implications.

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Hypertension 2016 Nov;68(5):1065

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November 2016

Clinical Implications.

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Hypertension 2016 Jan;67(1)

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January 2016

Too Fatty, Too Salty, Too Western.

Hypertension 2018 Nov;72(5):1078-1080

From the Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Australia (R.S.M., P.S., D.L.).

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November 2018

Cost-Utility of an Objective Biochemical Measure to Improve Adherence to Antihypertensive Treatment.

Hypertension 2018 Nov;72(5):1090-1092

Care Coordination Institute, Greenville, SC (B.M.E., C.R.).

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November 2018

De Novo DNA (de)Methylation in the Kidney.

Hypertension 2018 Nov;72(5):1084-1086

From the Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, and Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson.

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November 2018
6 Reads

PARP-1 (Poly[ADP-Ribose] Polymerase-1).

Hypertension 2018 Nov;72(5):1087-1089

From the Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, United Kingdom.

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November 2018

Cutting the Fat.

Hypertension 2018 Nov;72(5):1081-1083

From the Department of Physiology, Augusta University, GA.

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November 2018

Cardiac Output Versus Total Peripheral Resistance.

Authors:
Bonita Falkner

Hypertension 2018 Nov;72(5):1093-1094

From the Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.

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November 2018

Arterial System.

Hypertension 2018 Nov;72(5):1076-1077

Sorbonne Paris Cité, CART, INSERM U965, Université Paris Diderot, France (N.K.).

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November 2018

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.

Hypertension 2018 Nov;72(5):e53-e90

Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic. The antihypertensive drugs should be administered at maximum or maximally tolerated daily doses. RH also includes patients whose BP achieves target values on ≥4 antihypertensive medications. Read More

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November 2018
1 Read

Sitting Less and Moving More: Implications for Hypertension.

Hypertension 2018 11;72(5):1037-1046

From the Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (P.C.D., R.N.L., D.W.D., N.O., B.A.K.).

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November 2018

Noncoding RNAs in the Regulatory Network of Hypertension.

Hypertension 2018 Nov;72(5):1047-1059

From the Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, P.R. China (G.W., C.Z.).

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November 2018
1 Read

Emerging Paradigms in Chronic Kidney Ischemia.

Hypertension 2018 Nov;72(5):1023-1030

From the Divisions of Nephrology and Hypertension (A.E., S.C.T., L.O.L.), Mayo Clinic, Rochester, MN.

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November 2018
6.480 Impact Factor

Branched-Chain Amino Acids as Critical Switches in Health and Disease.

Hypertension 2018 Nov;72(5):1012-1022

From the KU Leuven Department of Cardiovascular Sciences, Research Unit Hypertension and Cardiovascular Epidemiology (Z.-Y.Z., J.A.S.), University of Leuven, Belgium.

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November 2018

Recent Advances in Therapeutic Vaccines to Treat Hypertension.

Hypertension 2018 Nov;72(5):1031-1036

Department of Clinical Gene Therapy (R.M.), Graduate School of Medicine, Osaka University, Japan.

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November 2018
3 Reads

The Meaning of Mas.

Hypertension 2018 Nov;72(5):1072-1075

Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.M.T.).

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November 2018

Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.

Hypertension 2018 Nov;72(5):1103-1108

From the Department of Population Science and Experimental Medicine, Institute of Cardiovascular Sciences, University College London, United Kingdom (C.P., S.J., N.C., A.D.H.).

Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)-a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)-a prospective population-based birth cohort study. Read More

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November 2018
59 Reads
6.480 Impact Factor

Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats.

Hypertension 2018 Nov;72(5):e43-e52

From the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (R.F., H.G., J.J.G., G.D.F., H.X.).

We examined the impact of sex on high-fat diet (HFD)-induced renal alterations in Dahl salt-sensitive and Sprague Dawley rats. In Dahl rats, HFD (60% kcal from fat for 24-26 weeks starting at weaning) significantly and equally increased blood pressure in males and females when compared with rats fed a control diet (10% kcal from fat). Male Dahl rats on HFD exhibited progressive renal histological injury and moderately increased renal macrophage infiltration at 10 and 24 weeks of feeding when compared with males on control diet. Read More

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November 2018
15 Reads

PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.

Hypertension 2018 Nov;72(5):1189-1199

Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China (H.W., J.-n.Z., F.Z., Y.M., X.-m.C., W.-d.Q.).

Abdominal aortic aneurysm (AAA) is a common vascular degenerative disease. PARP-1 (poly[ADP-ribose] polymerase 1) is a nuclear enzyme, which plays a critical role in vascular diseases. We hypothesized that PARP-1 inhibition might have protective effects on AAA. Read More

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November 2018
4 Reads

Cost-Utility of an Objective Biochemical Measure to Improve Adherence to Antihypertensive Treatment.

Hypertension 2018 Nov;72(5):1117-1124

From the Unit of PharmacoTherapy, -Epidemiology, and -Economics, Department of Pharmacy, University of Groningen, The Netherlands (A.V.v.S., A.D.I.v.A., M.J.P.).

Nonadherence to antihypertensive medications is known to be a major health problem. Novel biochemical analyses using liquid chromatography-tandem mass spectrometry are becoming accepted as a clinically useful objective measure to manage (non)adherence in Hypertension Clinics. Discussion of results from such analyses with patients can significantly improve adherence and blood pressure control. Read More

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November 2018
8 Reads

Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea.

Hypertension 2018 Nov;72(5):1141-1150

Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.).

Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models of hypertension and hypertensive patients. We have shown that gut dysbiosis plays a causal role in the development of hypertension in a rat model of obstructive sleep apnea (OSA). Functional analysis of the dysbiotic microbiota in OSA demonstrates a loss of short chain fatty acid-producing bacteria. Read More

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November 2018
1 Read

Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension.

Hypertension 2018 Nov;72(5):1160-1171

Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee (P.L., Y. Liu, X.P., Y. Li, K.U., M.K.M., M.L.).

Numerous adult diseases involving tissues consisting primarily of nondividing cells are associated with changes in DNA methylation. It suggests a pathophysiological role for de novo methylation or demethylation of DNA, which is catalyzed by DNA methyltransferase 3 and ten-eleven translocases. However, the contribution of DNA de novo (de)methylation to these diseases remains almost completely unproven. Read More

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November 2018
4 Reads

Body Silhouette Trajectories Across the Lifespan and Vascular Aging.

Hypertension 2018 Nov;72(5):1095-1102

From the Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France (T.T.v.S., P.B., Q.L., M.T., C.G., R.E.C., J.E.S., S.L., X.J., J.-P.E.).

Vascular aging is a major contributor to cardiovascular disease and can be quantified by higher carotid stiffness, intima-media thickness and diameter, and hypertension. Weight gain across the lifetime may be an important, modifiable determinant of vascular aging. We therefore aimed to assess lifetime body silhouette trajectories (a marker of weight change across the lifespan) in relation to vascular aging in late adulthood. Read More

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November 2018
9 Reads

Klotho Ameliorates Medullary Fibrosis and Pressure Natriuresis in Hypertensive Rat Kidneys.

Hypertension 2018 Nov;72(5):1151-1159

Department of Nephrology, Saitama Medical University, Iruma, Japan (T.I., T.M., H.S.).

Renal expression of klotho is reduced in hypertension. Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensive rats (sp-SHR). The interactions between klotho protein and renal renin-Ang (angiotensin) system were examined with immunoprecipitation and cell culture methods. Read More

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November 2018
1 Read

Diagnosing Masked Hypertension Using Ambulatory Blood Pressure Monitoring, Home Blood Pressure Monitoring, or Both?

Hypertension 2018 Nov;72(5):1200-1207

From Department of Medicine, Columbia University Medical Center, New York, NY (D.E.A, N.A.B, D.N.P, I.M.K., J.E.S., D.S.).

Guidelines recommend measuring out-of-clinic blood pressure (BP) to identify masked hypertension (MHT) defined by out-of-clinic BP in the hypertensive range among individuals with clinic-measured BP not in the hypertensive range. The aim of this study was to determine the overlap between ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) for the detection of MHT. We analyzed data from 333 community-dwelling adults not taking antihypertensive medication with clinic BP <140/90 mm Hg in the IDH study (Improving the Detection of Hypertension). Read More

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November 2018

Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1.

Hypertension 2018 Nov;72(5):1125-1132

From the Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, OH (H.W., X.C., S.G., B.M., G.V., M.V.K., B.J.).

G-protein-coupled estrogen receptor, Gper1, has been implicated in cardiovascular disease, but its mechanistic role in blood pressure control is poorly understood. Here, we demonstrate that genetically salt-sensitive hypertensive rats with complete genomic excision of Gper1 by a multiplexed guide RNA CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR associated proteins) approach present with lower blood pressure, which was accompanied by altered microbiota, different levels of circulating short chain fatty acids, and improved vascular relaxation. Microbiotal transplantation from hypertensive Gper1 rats reversed the cardiovascular protective effect exerted by the genomic deletion of Gper1. Read More

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November 2018
3 Reads
6.480 Impact Factor

Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation.

Hypertension 2018 Nov;72(5):1227-1235

From the Department of Pharmacology, UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa.

Low-salt diet is beneficial in salt-sensitive hypertension but may provoke cardiovascular risk in patients with heart failure, diabetes mellitus, or other cardiovascular abnormalities because of endogenous renin-angiotensin system activation. PPAR (peroxisome proliferator-activated receptor)-γ is a transcription factor which promotes an antioxidant pathway in the endothelium. We studied transgenic mice expressing a dominant-negative mutation in PPAR-γ selectively in the endothelium (E-V290M) to test the hypothesis that endothelial PPAR-γ plays a protective role in response to low salt-mediated renin-angiotensin system activation. Read More

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November 2018
1 Read
6.480 Impact Factor

Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease.

Hypertension 2018 Nov;72(5):1217-1226

From the Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, QC, Canada.

The angiotensin receptor blocker losartan mitigated cerebrovascular and cognitive deficits in mouse models of Alzheimer disease, in line with some clinical evidence of reduced onset and progression to Alzheimer disease. We investigated whether these benefits apply to another angiotensin receptor blocker, namely candesartan. Adult transgenic mice overexpressing a mutated form of the human APP (amyloid precursor protein) and wild-type controls were treated with vehicle or candesartan (cohort 1: 2 months, 1 mg/kg per day, osmotic subcutaneous minipumps; cohort 2: 5 months, 10 mg/kg per day in drinking water). Read More

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November 2018

High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Hypertension 2018 Nov;72(5):1208-1216

From the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).

High salt, Ang II (angiotensin II), and reactive oxygen species enhance progression of chronic kidney disease. We tested the hypothesis that a high salt intake generates specific reactive oxygen species to enhance Ang II contractions of afferent arterioles from mice with reduced renal mass (RRM). C57BL/6 mice were subjected to surgical RRM or sham operations and received 6% or 0. Read More

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November 2018

Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity.

Hypertension 2018 Nov;72(5):1172-1179

From the Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.-Z.Z., S.W., Y.W., Y.Z., R.C.H.).

COX (cyclooxygenase)-derived prostaglandins regulate renal hemodynamics and salt and water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition, chronic analgesic abuse can induce renal injury, including papillary necrosis. Read More

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November 2018
7 Reads

Associations Between Characteristics of Obstructive Sleep Apnea and Nocturnal Blood Pressure Surge.

Hypertension 2018 Nov;72(5):1133-1140

From the Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Japan (N.S.).

Research suggests that oxygen desaturation and sleep stage during obstructive sleep apnea (OSA) are related to the magnitude of high blood pressure (BP) in a laboratory setting. However, in a clinical setting, these associations have not been well studied. We used a noninvasive oscillometric BP measurement device to investigate the association between oxygen-triggered BP levels at the end of each OSA episode and the characteristics of the preceding OSA episode. Read More

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November 2018
1 Read

Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels.

Hypertension 2018 Nov;72(5):1180-1188

From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (I.O.S., A.S., A.A., A.E., C.M.F., J.R.W., S.C.T., A.S.P., L.O.L.).

Hypertension, an important cause of chronic kidney disease, is characterized by peritubular capillary (PTC) loss. Circulating levels of endothelial microparticles (EMPs) reflect systemic endothelial injury. We hypothesized that systemic and urinary PTC-EMPs levels would reflect renal microvascular injury in hypertensive patients. Read More

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November 2018
1 Read
6.480 Impact Factor

Pulse Wave Velocity Is Associated With Greater Risk of Dementia in Mild Cognitive Impairment Patients.

Hypertension 2018 Nov;72(5):1109-1116

From the EA 4468, Université Paris Descartes, Sorbonne Paris Cité, France (L.R., H.B., M.B., A.C., D.D., I.H., M.-L.S., J.-S.V., O.H.).

To investigate the association between pulse wave velocity, intima-media thickness, carotid artery diameter, carotid plaques, and conversion from mild cognitive impairment to dementia. Three hundred and seventy-five elderly ambulatory subjects with mild cognitive impairment were followed yearly to examine potential conversion to dementia. Vascular function was assessed by carotid-femoral pulse wave velocity. Read More

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November 2018
5 Reads

Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women.

Hypertension 2018 Nov;72(5):1236-1242

From the Department of Anesthesiology, Mayo Clinic, Rochester, MN.

Autonomic support of blood pressure increases with age in humans. Large differences exist in the dose of trimethaphan (TMP) required for ganglionic blockade in young and older women. We asked whether differences in the dose of TMP required to achieve ganglionic blockade are because of differences in the relative contributions of the sympathetic and parasympathetic nervous system in control of blood pressure with age. Read More

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November 2018

Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension.

Authors:
Allen W Cowley

Hypertension 2018 Sep;72(3):588-591

From the Department of Physiology, Medical College of Wisconsin, Milwaukee.

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September 2018

Prevalence of Obstructive Sleep Apnea in Refractory Hypertension.

Hypertension 2018 Sep;72(3):592-593

From the Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Brazil.

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September 2018
1 Read