14,203 results match your criteria Hypertension[Journal]


Markers or Makers.

Hypertension 2019 Feb 19:HYPERTENSIONAHA11912604. Epub 2019 Feb 19.

From the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12604DOI Listing
February 2019

Aging, Arterial Stiffness, and Blood Pressure Association in Chinese Adults.

Hypertension 2019 Feb 19:HYPERTENSIONAHA11812396. Epub 2019 Feb 19.

Department of Nutritional Sciences, Pennsylvania State University, State College (X. Zhang, X.G.).

Arterial stiffness and blood pressure (BP) both increase with aging synchronously. Whether elevated BP results from thickening of arterial wall or vice versa is controversial in previous studies. This study included 17 862 participants without history of myocardial infarction, stroke, atrial fibrillation or flutter, or cancer and with brachial-ankle pulse wave velocity (baPWV) and BP measurements during 2010 to 2016. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12396DOI Listing
February 2019

Hypertension Development by Midlife and the Roles of Premorbid Cognitive Function, Sex, and Their Interaction.

Hypertension 2019 Feb 19:HYPERTENSIONAHA11812164. Epub 2019 Feb 19.

From the Department of Psychology, University of Edinburgh, United Kingdom (D.M.A., C.W., I.J.D.).

Higher early-life cognitive function is associated with better later-life health outcomes, including hypertension. Associations between higher prior cognitive function and less hypertension persist even when accounting for socioeconomic status, but socioeconomic status-hypertension gradients are more pronounced in women. We predicted that differences in hypertension development between sexes might be associated with cognitive function and its interaction with sex, such that higher early-life cognitive function would be associated with lower hypertension risk more in women than in men. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12164DOI Listing
February 2019

Apneic Sleep, Insufficient Sleep, and Hypertension.

Hypertension 2019 Feb 19:HYPERTENSIONAHA11811780. Epub 2019 Feb 19.

From the Center for Sleep Medicine (M.P.M.) and Department of Cardiovascular Diseases (N.C., V.K.S.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11780DOI Listing
February 2019

Inflammation and Apparent Treatment-Resistant Hypertension in Patients With Chronic Kidney Disease.

Hypertension 2019 Feb 19:HYPERTENSIONAHA11812358. Epub 2019 Feb 19.

From the Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C., L.L.H., J.H.).

Apparent treatment-resistant hypertension (ATRH) is highly prevalent and associated with cardiovascular disease risk in patients with chronic kidney disease. We analyzed the association of inflammatory biomarkers with ATRH and its complications in patients with chronic kidney disease. ATRH was defined as blood pressure ≥140/90 mm Hg while taking ≥3 antihypertensive medications or blood pressure <140/90 mm Hg while taking ≥4 medications. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12358DOI Listing
February 2019

Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females: The Enigma Study

Hypertension 2018 Dec 15;72(6):1277-1284. Epub 2018 Oct 15.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom

Blood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221425PMC
December 2018
1 Read

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan)

Hypertension 2019 Jan 19;73(1):52-59. Epub 2018 Nov 19.

Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo

Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11635DOI Listing
January 2019
4 Reads

Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II-Induced Microvascular Dysfunction.

Hypertension 2019 Feb 11:HYPERTENSIONAHA11812286. Epub 2019 Feb 11.

From the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).

Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic and inflammatory abnormalities. Although T cells and IL-6 (interleukin-6) play an important role in adaptive immune responses, little is known about their role(s) in the thromboinflammatory responses associated with Ang II. Here we show using intravital microscopy coupled with the light/dye injury model that Rag-1 deficient (Rag-1) and IL-6 deficient (IL-6) mice are afforded protection against Ang II-induced thrombosis. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12286DOI Listing
February 2019
4 Reads
6.480 Impact Factor

Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

Hypertension 2019 Feb 11:HYPERTENSIONAHA11812070. Epub 2019 Feb 11.

From the Department of Molecular and Integrative Physiology (K.N., W.E.R.), University of Michigan, Ann Arbor.

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent studies, there appears to be racial differences in the prevalence of somatic KCNJ5 mutations, particularly between East Asians and Europeans. Despite the high cardiovascular disease mortality of blacks, there have been no studies focusing on somatic mutations in APAs in this population. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12070DOI Listing
February 2019
1 Read

Greater Blood Pressure Variability Is Associated With Lower Cognitive Performance.

Hypertension 2019 Feb 11:HYPERTENSIONAHA11812305. Epub 2019 Feb 11.

From the Department of Internal Medicine (T.L.Z., A.A.K., M.T.S., C.D.A.S., R.M.A.H.), Maastricht University Medical Centre, the Netherlands.

An increasing number of individuals will face age-related cognitive difficulties because life expectancy has increased. It is, therefore, important to identify modifiable risk factors for cognitive impairment. Very short-term to mid-term blood pressure variability (BPV) may be such a factor because it may cause cerebral ischemia. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12305DOI Listing
February 2019
1 Read

Impact of Coming Demographic Changes on the Number of Adults in Need of Care for Hypertension in Brazil, China, India, Indonesia, Mexico, and South Africa.

Hypertension 2019 Feb 11:HYPERTENSIONAHA11812337. Epub 2019 Feb 11.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA (P.G.).

Over the coming decades, middle-income countries are expected to undergo substantial demographic changes. We estimated the consequences of these changes on the number of adults in need of hypertension care between 2015 and 2050 using nationally representative household-survey data collected in Brazil, China, India, Indonesia, Mexico, and South Africa (N=770 121). To reflect unmet need for healthcare, we defined hypertension as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg regardless of treatment status. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12337DOI Listing
February 2019

Urine Haptoglobin and Haptoglobin-Related Protein Predict Response to Spironolactone in Patients With Resistant Hypertension.

Hypertension 2019 Feb 4:HYPERTENSIONAHA11812242. Epub 2019 Feb 4.

From the Laboratory of Immunoallergy and Proteomics, Department of Immunology, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain (M.M.-L., P.J.M., A.S.-H., G.A.-L.).

Resistant hypertension prevalence is progressively increasing, and prolonged exposure to suboptimal blood pressure control results in higher cardiovascular risk and end-organ damage. Among various antihypertensive agents, spironolactone seems the most effective choice to treat resistant hypertension once triple therapy including a diuretic fails. However success in blood pressure control is not guaranteed, adverse effects are not negligible, and no clinical tools are available to predict patient's response. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12242DOI Listing
February 2019

Cardiovascular System in Preeclampsia and Beyond.

Hypertension 2019 Mar;73(3):522-531

Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara University, Turkey (E.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11191DOI Listing

Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity.

Hypertension 2019 Feb 4:HYPERTENSIONAHA11812425. Epub 2019 Feb 4.

From the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (D.D.G., J.C.C., Z.Z., A.E.G.P., E.W., J.O.L., M.C.).

Several experimental and clinical studies have shown that dietary nitrate supplementation can increase nitric oxide bioavailability. In the oral cavity, commensal bacteria reduce nitrate to nitrite, which is subsequently absorbed into the circulation where reduction to nitric oxide by enzymatic systems occur. Although it is well-known that boosting the nitrate-nitrite-nitric oxide pathway can improve cardiovascular, renal, and metabolic functions and that sympathoexcitation contributes to the development of the same disorders, the potential effects of dietary nitrate on sympathetic activity remain to be elucidated. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12425DOI Listing
February 2019
1 Read

Unattended Versus Attended Blood Pressure Measurement.

Hypertension 2019 Mar;73(3):736-742

From the Department of Clinical and Experimental Sciences, University of Brescia, 2a Medicina ASST Spedali Civili di Brescia, Italy.

It has been suggested that measurement of unattended or automated oscillatory blood pressure (BP) values may provide advantages over conventional BP measurement. Some international guidelines now suggest automated oscillatory BP as the preferred approach for measuring BP. Data on the relationship between automated oscillatory BP and cardiovascular events are much less solid as compared to those obtained with the standard approach; preliminary data suggested that automated oscillatory BP might be more strictly correlated with organ damage. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12187DOI Listing

Caloric Restriction Exacerbates Angiotensin II-Induced Abdominal Aortic Aneurysm in the Absence of p53.

Hypertension 2019 Mar;73(3):547-560

From the Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, China (P.G., H.Z., H.W., Z.L., X.W., Z.Y., D.L., Z.Z.).

p53-dependent vascular smooth muscle cell senescence is a key pathological process of abdominal aortic aneurysm (AAA). Caloric restriction (CR) is a nonpharmacological intervention that prevents AAA formation. However, whether p53 is indispensable to the protective role of CR remains unknown. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12086DOI Listing
March 2019
1 Read
6.480 Impact Factor

Blood Pressure and Cognitive Function in Children and Adolescents.

Hypertension 2019 Mar;73(3):532-540

Department of Pediatrics, Maimonides Medical Center, Brooklyn, NY (J.C.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374155PMC

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease.

Hypertension 2019 Jan 28:HYPERTENSIONAHA11812261. Epub 2019 Jan 28.

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (B.L., S.R., M.U.M., A.G., J.D.).

The plasma levels of long noncoding RNA LIPCAR are elevated in heart failure (HF) patients with reduced ejection fraction and associated with left ventricular remodeling and poor outcomes. We studied whether the presence of chronic kidney disease (CKD), as defined by an estimated glomerular filtration rate value <60mL/(min·1.73m2) modified the associations of plasma LIPCAR with left ventricular remodeling and outcomes in HF patients. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12261DOI Listing
January 2019

Paying the Toll for Inflammation.

Hypertension 2019 Mar;73(3):514-521

Department of Physiology, Augusta University, GA (R.C.W.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11782DOI Listing
March 2019
1 Read

Pregnancy Increases Ca Sparks/Spontaneous Transient Outward Currents and Reduces Uterine Arterial Myogenic Tone.

Hypertension 2019 Mar;73(3):691-702

From the Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, CA.

Spontaneous transient outward currents (STOCs) at physiological membrane potentials of vascular smooth muscle cells fundamentally regulate vascular myogenic tone and blood flow in an organ. We hypothesize that heightened STOCs play a key role in uterine vascular adaptation to pregnancy. Uterine arteries were isolated from nonpregnant and near-term pregnant sheep. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374197PMC
March 2019
1 Read

Relative Contributions of Pulse Pressure and Arterial Stiffness to Cardiovascular Disease.

Hypertension 2019 Mar;73(3):712-717

From the Framingham Heart Study, MA (T.J.N., R.S.V.).

Pulse pressure has been frequently used as a surrogate marker of arterial compliance. However, the prevalence and prognostic significance of mismatch between pulse pressure and arterial stiffness remains unclear. We measured carotid-femoral pulse wave velocity (CFPWV) and central pulse pressure (CPP) in 2119 Framingham Offspring Cohort participants (mean age, 60 years; 57% women). Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374179PMC
March 2019
2 Reads

Effects of Bariatric Surgery Versus Medical Therapy on the 24-Hour Ambulatory Blood Pressure and the Prevalence of Resistant Hypertension.

Hypertension 2019 Mar;73(3):571-577

Hypertension Unit, Renal Division (S.d.B., L.F.D.), University of São Paulo Medical School, Brazil.

Bariatric surgery is an effective strategy for blood pressure (BP) reduction, but most of the evidence relies on office BP measurements. In this study, we evaluated the impact of bariatric surgery on 24-hour BP profile, BP variability, and resistant hypertension prevalence. This is a randomized trial including obese patients with grade 1 and 2 using at least 2 antihypertensive drugs at maximal doses or >2 at moderate doses. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12290DOI Listing
March 2019
7 Reads

Cardiometabolic Surgery for Treatment of Hypertension?

Hypertension 2019 Mar;73(3):543-546

From the Department of Physiology and Biophysics (J.E.H., M.E.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374201PMC

Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation.

Hypertension 2019 Mar;73(3):718-727

From the Cardiovascular Program, Monash Biomedicine Discovery Institute and Department of Physiology (R.R.S., Z.M.M., M.I., L.K.E., H.C.P., K.M.D.), Monash University, Melbourne, Australia.

We examined whether renal denervation (RDN) reduced blood pressure (BP), improved glomerular filtration rate, albuminuria, and left ventricular mass in sheep with hypertensive chronic kidney disease (CKD). To examine whether renal nerve function returned in the long term, we examined vascular contraction to nerve stimulation in renal arteries and determined nerve regrowth by assessing renal TH (tyrosine hydroxylase), CGRP (calcitonin gene-related peptide), and norepinephrine levels in kidneys at 30 months after RDN. RDN normalized BP in hypertensive CKD sheep such that BP was similar to that of the normotensive sheep with intact nerves. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12250DOI Listing
March 2019
3 Reads

Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow.

Hypertension 2019 Mar;73(3):587-593

From the Department of Kinesiology and Applied Physiology, University of Delaware, Newark (M.C.B., A.T.R., K.U.M., J.C.W., M.M.W., W.B.F.).

The American Heart Association recommends no more than 1500 mg of sodium/day as ideal. Some cohort studies suggest low-sodium intake is associated with increased cardiovascular mortality. Extremely low-sodium diets (≤500 mg/d) elicit activation of the renin-angiotensin-aldosterone system and stimulate sympathetic outflow. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374182PMC

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.

Hypertension 2019 Mar;73(3):640-649

From the Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology (F.v.V.-H., R.R.F., W.Z., V.L.B.), Stanford University School of Medicine, Sunnyvale, CA.

In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in vitro fertilization protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether in vitro fertilization pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12043DOI Listing
March 2019
8 Reads

B-Cell Deficiency Lowers Blood Pressure in Mice.

Hypertension 2019 Mar;73(3):561-570

From the Toronto General Hospital Research Institute, University Health Network, Canada (L.S.D., E.A.S., A.M., T.A., F.B., M.H.).

The proto-oncogene c-myb (and corresponding nuclear transcription factor, c-Myb) regulates the proliferation and differentiation of hematologic and vascular smooth muscle cells; however, the role of c-Myb in blood pressure regulation is unknown. Here, we show that mice homozygous for a hypomorphic c-myb allele ( c-myb ) conferring reduced c-Myb activity manifest reduced peripheral blood and kidney B220 B-cells and have decreased systolic (104±2 versus 120±1 mm Hg; P<0.0001) and diastolic blood pressure (71±2 versus 83±1 mm Hg; P<0. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11828DOI Listing
March 2019
1 Read

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion.

Hypertension 2019 Mar;73(3):659-670

From the Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia (R.H., F.C.B., N.P., N.J.H., P.C., V.N., S.B., S.T., T.J.K.-L.).

Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1 (soluble FMS-like tyrosine kinase-1) has been strongly implicated in the pathogenesis of preeclampsia. sFlt-1 is secreted into the maternal circulation where it antagonizes VEGF (vascular endothelial growth factor) and ultimately disrupts vascular homeostasis. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12300DOI Listing
March 2019
1 Read

Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy.

Hypertension 2019 Mar;73(3):680-690

Department of Obstetrics and Gynecology, Stanford University Medical Center, CA (P.N., N.M., V.D.W.).

Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Vascular dysfunction predates clinical presentation of preeclampsia. Therefore, we examined if a nonphysiological hormonal milieu, a modifiable state, affects maternal vascular health in early pregnancy. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378337PMC
March 2019
3 Reads

Male and Female Intrauterine Growth-Restricted Offspring Differ in Blood Pressure, Renal Function, and Glucose Homeostasis Responses to a Postnatal Diet High in Fat and Sugar.

Hypertension 2019 Mar;73(3):620-629

From the Department of Physiology and Biophysics (S.I., J.H.D., J.M.J., A.D.B., B.T.A.), University of Mississippi Medical Center, Jackson.

It is well established that inadequate nutrition during fetal life followed by postnatal overabundance programs adiposity and glucose intolerance. Studies addressing sexual dimorphism in developmental responses to a dietary mismatch are limited; the effect on blood pressure and renal function is understudied. Therefore, this study tested the hypothesis that a mismatch of prenatal and postnatal nutrition heightens cardiorenal and metabolic risk, outcomes that may vary by sex. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374157PMC
March 2019
1 Read

Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults.

Hypertension 2019 Mar;73(3):578-586

From the Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (A.J., R.G., C.M.O., S.J.F.-T., A.-M.M., A.C.).

We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12259DOI Listing

Targeted Delivery of Sildenafil for Inhibiting Pulmonary Vascular Remodeling.

Hypertension 2019 Mar;73(3):703-711

Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, Nanjing (K.H.).

Pulmonary arterial hypertension is a fatal lung disease caused by the progressive remodeling of small pulmonary arteries (PAs). Sildenafil can prevent the remodeling of PAs, but conventional sildenafil formulations have shown limited treatment efficacy for their poor accumulation in PAs. Here, glucuronic acid (GlcA)-modified liposomes (GlcA-Lips) were developed to improve the delivery of sildenafil to aberrant over-proliferative PA smooth muscle cells via targeting the GLUT-1 (glucose transport-1), and, therefore, inhibiting the remodeling of PAs in a monocrotaline-induced PA hypertension model. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11932DOI Listing
March 2019
1 Read

Implementation of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline.

Authors:
Brent M Egan

Hypertension 2019 Feb;73(2):288-290

From the Department of Medicine, University of South Carolina School of Medicine Greenville, SC; and Care Coordination Institute, Greenville, SC.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11712DOI Listing
February 2019

Comparison of Automated Office Blood Pressure With Office and Out-Off-Office Measurement Techniques.

Hypertension 2019 Feb;73(2):481-490

From the Hypertension Unit, Division of Internal Medicine, Department of Medical Sciences (M.P., S.D.M., E.P., J.B., S.M., F.R., F.V.), University of Turin, Italy.

Automated office blood pressure (AOBP) has emerged as a valuable tool to assess patient's BP status, but the lack of strong evidence to establish a threshold value for hypertension diagnosis limits its use in clinical practice. We aimed at synthesizing the published literature through a meta-analysis of studies comparing AOBP with other BP measurement techniques and at analyzing the differences between AOBP and physician's office BP, nonphysician's office BP, daytime ambulatory BP monitoring, and home BP monitoring. We searched PubMed database for articles published up to April 2018; eligible studies compared AOBP with office and out-of-office measurement techniques and reported the BP differences or BP values obtained. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12079DOI Listing
February 2019

Evidence for a Causal Role of the SH2B3-βM Axis in Blood Pressure Regulation.

Hypertension 2019 Feb;73(2):497-503

From the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).

Genetic variants at SH2B3 are associated with blood pressure and circulating βM (β-2 microglobulin), a well-characterized kidney filtration biomarker. We hypothesize that circulating βM is an independent risk predictor of hypertension and may causally contribute to its development. The study sample consisted of 7 065 Framingham Heart Study participants with measurements of plasma βM. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334659PMC
February 2019
1 Read
6.480 Impact Factor

Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm.

Hypertension 2019 Feb;73(2):491-496

From the Department of Neurosurgery and Neurobiology, Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, AZ.

Gut microbiota modulates metabolic and immunoregulatory axes and contributes to the pathophysiology of diseases with inflammatory components, such as atherosclerosis, diabetes mellitus, and ischemic stroke. Inflammation is emerging as a critical player in the pathophysiology of an intracranial aneurysm. Therefore, we hypothesized that the gut microbiota affects aneurysm formation by modulating inflammation. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11804DOI Listing
February 2019
3 Reads

Steps per Day and Arterial Stiffness.

Hypertension 2019 Feb;73(2):350-363

From the Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain (I.C.-R., C.A.-B., V.M.-V.).

Arterial stiffness has emerged as an independent predictor of cardiovascular morbidity and mortality. Furthermore, objectively monitored steps per day is widely perceived to be beneficial for controlling health risk factors, and for preventing morbidity and mortality. The aim of this review was to determine the relationship between steps per day and arterial stiffness, as measured by its reference standard, pulse wave velocity (PWv). Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11987DOI Listing
February 2019
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MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity.

Hypertension 2019 Feb;73(2):458-468

From the Department of Physiology, INSERM UMRS 1138 Team 1, Centre de Recherche des Cordeliers, Sorbonne University, Paris, France (C.L., R.P.-R., N.B., F.J., A.N.D.C.).

Adipose tissue (AT) senescence and mitochondrial dysfunction are associated with obesity. Studies in obese patients and animals demonstrate that the MR (mineralocorticoid receptor) contributes to obesity-associated cardiovascular complications through its specific role in AT. However, underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11873DOI Listing
February 2019
2 Reads

Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms.

Hypertension 2019 Feb;73(2):250-257

From the Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, Department of Medicine, University of Illinois at Chicago (I.S.F., I.R., I.L.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338082PMC
February 2019

Deep Vascular Phenotyping in Patients With Renal Multifocal Fibromuscular Dysplasia.

Hypertension 2019 Feb;73(2):371-378

APHP, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France (H.K., A.L., M.F., X.J., S.L., P.B., M.A.).

Arterial fibromuscular dysplasia is a nonatherosclerotic, noninflammatory vascular disease, whose pathophysiology is still unknown. We performed deep image-based vascular phenotyping of nonaffected arteries to look for systemic vascular alterations in fibromuscular dysplasia. This single center cross-sectional study included 50 patients with multifocal renal fibromuscular dysplasia, 50 hypertensive patients, and 50 healthy controls, matched for age, sex, and ethnicity; hypertensive patients were matched also for blood pressure. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12189DOI Listing
February 2019

Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans.

Hypertension 2019 Feb;73(2):310-318

Department of Medicine, University of Alabama at Birmingham School of Medicine (V.G.W.).

Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex. In a prospective national study of 22 164 blacks and whites ≥45 years without baseline cognitive impairment or stroke from the REGARDS cohort study (Reasons for Geographic and Racial Differences in Stroke), enrolled 2003 to 2007 and followed through September 2015, we measured changes in cognition associated with baseline systolic and diastolic BP (SBP and DBP), as well as pulse pressure (PP) and mean arterial pressure, and we tested whether age, race, and sex modified the effects. Outcomes were global cognition (Six-Item Screener; primary outcome), new learning (Word List Learning), verbal memory (Word List Delayed Recall), and executive function (Animal Fluency Test). Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12062DOI Listing
February 2019
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6.480 Impact Factor

Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus.

Hypertension 2019 Feb;73(2):319-326

From the Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital (M.K.K., H.-S.K.), College of Medicine, Catholic University of Korea, Seoul.

The objective of this study was to investigate the optimal blood pressure (BP) target to prevent development of cardiovascular diseases (CVDs) in Korean subjects with type 2 diabetes mellitus. Using the Korean National Health Insurance Service database, 2 262 725 subjects with type 2 diabetes mellitus who underwent regular health checks between 2009 and 2012 were included. Subjects with previous CVDs were excluded. Read More

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February 2019

Superimposed Preeclampsia Exacerbates Postpartum Renal Injury Despite Lack of Long-Term Blood Pressure Difference in the Dahl Salt-Sensitive Rat.

Hypertension 2019 Mar;73(3):650-658

From the Departments of Pharmacology and Toxicology (H.R.T., M.R.G., S.P.D., J.M.S.), University of Mississippi Medical Center, Jackson.

Preeclampsia results in increased susceptibility to hypertension and chronic kidney disease postpartum; however, the mechanisms responsible for disease progression in these women remain unknown. The purpose of this study was to test the hypothesis that 2 mechanisms contribute to the link between the maternal syndrome of preeclampsia and the increased postpartum risk of cardiovascular and renal disease: (1) increased T cells in the kidney and (2) a decreased NO:ET-1 (endothelin-1) ratio. Dahl S rats (a previously characterized model of preeclampsia superimposed on chronic hypertension) who experienced 2 pregnancies and virgin littermate controls were studied at 6 months of age. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374193PMC
March 2019
3 Reads

High Normal Blood Pressure and Left Ventricular Hypertrophy Echocardiographic Findings From the PAMELA Population.

Hypertension 2019 Mar;73(3):612-619

From the Department of Medicine and Surgery, University of Milano-Bicocca, Italy (C.C., R.F., M.B., G.G., G.M.).

Cross-sectional and longitudinal data analysis of the PAMELA (Pressioni Monitorate E Loro Associazioni) population was performed to assess the association between prehypertension and left ventricular hypertrophy (LVH) at entry and the risk of new-onset LVH associated to this condition in the subset of participants with normal LV mass index (LVMI). A total of untreated 1397 participants with measurable echocardiographic parameters at baseline were considered in the cross-sectional analysis. The longitudinal analysis included 880 participants without LVH at baseline and with measurable LVMI at follow-up examination performed 10 years later. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12114DOI Listing
March 2019
6 Reads

Prognostic Impact of Aortic Stiffness in Patients With Resistant Hypertension.

Hypertension 2019 Mar;73(3):728-735

From the Department of Internal Medicine, School of Medicine, University Hospital Clementino Fraga Filho (C.R.L.C., G.F.S.), Universidade Federal do Rio de Janeiro, Brazil.

The prognostic importance of aortic stiffness in patients with resistant hypertension has never been investigated. We aimed to evaluate it for the occurrence of adverse cardiovascular outcomes and mortality in a prospective cohort of resistant hypertensive patients. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) at baseline in 891 resistant hypertensive patients who were followed-up for a median of 7. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12367DOI Listing