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Ecotoxicol Environ Saf 2019 Apr 15;178:113-122. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Sharkia Gov., Egypt. Electronic address:

The rational of the current study was to assess whether Tribulus terrestris extract (TTE) could alleviate long-term copper (Cu) overload-induced testicular dysfunction compared to enalapril and losartan. Rats were administered either vehicle (control group, n = 10) or copper sulfate pentahydrate (CuSO·5HO, 200 mg/kg, p.o) for 90 days (n = 40). Read More

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Key Lab of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address:

Angiotensin II (Ang II) modulates blood pressure via Ang II type 1 receptor (ATR) and type 2 receptor (ATR). The activation of ATR relaxes vascular tone through opening large-conductance Ca-activated potassium (BK) channels in vascular smooth muscle cells (SMCs). In the present study, we studied the role of the ATR-BK pathway in patients with hypertension. Read More

Can J Physiol Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Henry Ford Hospital, 24016, Hypertension & Vascular Research Division/Department of Internal Medicine, Detroit, Michigan, United States.

Myocardial infarction (MI) in mice results in cardiac rupture at 4-7 days post-MI, whereas cardiac fibrosis and dysfunction occur later. Ac-SDKP has anti-inflammatory, anti-fibrotic, and pro-angiogenic properties. We hypothesized that Ac-SDKP reduces cardiac rupture and adverse cardiac remodeling, and improves function by promoting angiogenesis and inhibiting detrimental reactive fibrosis and inflammation after MI. Read More

PLoS One 2019 18;14(4):e0215374. Epub 2019 Apr 18.

Department of Pain, Lanzhou University Second Hospital, Lanzhou, Gansu Province, People's Republic of China.

This study is to identify the risk factors for postoperative delirium (PODE) in patients undergoing microvascular decompression (MVD) for the treatment of primary cranial nerve disorders. We retrospectively reviewed the data of 912 patients (354 men, 558 women) with primary cranial nerve disorders (trigeminal neuralgia, 602 patients; hemifacial spasm, 296 patients; glossopharyngeal neuralgia, 14 patients) who underwent MVD in the Neurosurgery Department of Lanzhou University Second Hospital between July 2007 and June 2018. Potential risk factors for PODE were identified using univariate and multivariate stepwise logistic regression analysis. Read More

PLoS One 2019 18;14(4):e0214649. Epub 2019 Apr 18.

Bayer AG, Berlin, Germany.

Chronic thromboembolic pulmonary hypertension (CTEPH), a rare pulmonary vascular disease, is often misdiagnosed due to nonspecific symptoms. The objective of the study was to develop, refine and validate a case ascertainment algorithm to identify CTEPH patients within the French exhaustive hospital discharge database (PMSI), and to use it to estimate the annual number of hospitalized patients with CTEPH in France in 2015, as a proxy for disease prevalence. As ICD-10 coding specifically for CTEPH was not available at the time of the study, a case ascertainment algorithm was developed in close collaboration with an expert committee, using a two-step process (refinement and validation), based on matched data from PMSI and hospital medical records from 2 centres. Read More

PLoS Genet 2019 Apr 18;15(4):e1008110. Epub 2019 Apr 18.

Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. Read More

PLoS One 2019 18;14(4):e0211559. Epub 2019 Apr 18.

Kidney Disease Section, NIDDK, NIH, Bethesda, Maryland, United States of America.

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. Read More

Coron Artery Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiology, People's Hospital of Dongying.

Objective: To investigate the association of Wnt1-inducible signaling pathway protein 1 (WISP1) concentrations in circulation with the presence and severity of coronary artery disease (CAD).

Participants And Methods: A total of 120 consecutive participants who underwent coronary angiography between May 2017 and July 2018 at our center were enrolled. Participants were divided into two groups based on the presence of CAD. Read More

Blood Press Monit 2019 Apr 16. Epub 2019 Apr 16.

South African Hypertension and Diet Study, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objective: We aimed to establish reference values for 24 h ambulatory blood pressure (ABP) monitoring in an African community.

Patients And Methods: We randomly recruited 1219 participants of African ancestry from Soweto, a township in Johannesburg. Twenty-four hour ABP was measured using ABP monitors (model 90207; Spacelab). Read More

Blood Press Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.

Background: In longitudinal research studies with follow-up examinations, the devices used to measure phenotypes may change over time. When a device change occurs, the two devices should be calibrated to each other to ensure that measurements are comparable. This paper details the Jackson Heart Study (JHS) blood pressure (BP) comparability study. Read More

Blood Press Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Nusing, Université du Québec à Trois-Rivières, Trois-Rivières.

Background: Previous studies have examined the relevance of hypertension (HTN) screening in walk-in clinics. So far, no valid algorithm has been proposed on how to integrate HTN screening in this context. The aim of our study was to assess, in a walk-in clinic setting, the HTN screening strategy for performing an automated office blood pressure (AOBP) measurement following an initially high office blood pressure (OBP) measurement. Read More

Eur J Sport Sci 2019 Apr 18:1-10. Epub 2019 Apr 18.

d Department of Epidemiology and Preventive Medicine , University of Regensburg , Regensburg , Germany.

U.S. women are ageing. Read More

J Glob Oncol 2019 Apr(5):1-10

3 International Agency for Research on Cancer, Lyon, France.

Purpose: In recognition of the growing burden of noncommunicable diseases (NCDs), including cancer, we assessed the knowledge, attitudes, and practices of rural women in low-resourced countries toward common NCDs and the barriers they face in receiving NCD early detection services.

Patients And Methods: The study was conducted in a rural block of India using the Rapid Assessment and Response Evaluation ethnographic assessment, which included in-depth interviews of key health officials; focus group discussions with women, men, teachers, and health workers from the block; and a knowledge, attitudes, and practices questionnaire survey. The home-based survey was conducted among 1,192 women selected from 50 villages of the block using a two-stage randomization process and stratified to 30- to 44-year and 45- to 60-year age-groups. Read More

Circ Cardiovasc Interv 2019 Apr;12(4):e006918

Interventional Heart Program, Inova Health System, Inova Heart & Vascular Institute, Falls Church, VA (W.B.).

Background The impact of race/ethnicity on coronary stent outcomes in women is unknown. We compared baseline characteristics, social determinants of health, and 1-year outcomes in female African Americans (AA) and Hispanic/Latinas (HL) versus white women after coronary everolimus-eluting stent implantation in all-comer patients. Methods and Results We pooled 1863 women from the PLATINUM Diversity (n=1057 women) and PROMUS ELEMENT PLUS (n=806 women) postapproval studies, with some overlap in study sites. Read More

Circ Heart Fail 2019 Apr;12(4):e005565

Department of Medicine, Aab Cardiovascular Research Institute (R.M.B., J.K.L., D.M.M., E.M.S.), University of Rochester, NY.

Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility. Cardiac fibrosis arises from a pathological attempt to repair tissue damaged during maladaptive remodeling. Treatment options to block or reverse fibrosis have proven elusive. Read More

Circ Cardiovasc Interv 2019 Apr;12(4):e007133

Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, NY (M.F., U.B., S. Sartori, J.C., B.E.C., G.D., B.V., S. Sorrentino, A.K., S.F., R.M.).

Background: Anemia is a well-recognized risk factor for both bleeding and ischemic events after percutaneous coronary intervention (PCI). We sought to determine the impact of baseline anemia on dual antiplatelet therapy (DAPT) cessation patterns ≤2 years after PCI and the subsequent risk of clinical adverse events.

Methods And Results: PARIS (Patterns of Non-Adherence to Dual Anti-Platelet Regimen in Stented Patients) was a prospective multicenter observational registry of PCI-treated patients (n=5018). Read More

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

School of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taiwan.

Background: This study was to investigate the effects of exercise training on anti-apoptotic pathways and mitochondrial biogenesis in ovariectomized hypertensive rats.

Methods: Histopathological analysis, TUNEL assay and Western blotting were performed on the excised hearts from female spontaneously hypertensive rats (SHR), which were divided into a sham-operated sedentary hypertensive (SHR-S), a sedentary hypertensive ovariectomized (SHR-O), and hypertensive ovariectomized rats which underwent treadmill exercise training (SHR-OT, 60 min/day, 5 days/week) for 8 weeks, along with normotensive Wistar Kyoto rats (WKY).

Results: When compared with the WKY group, the SHR-S group exhibited decreased protein levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitochondrial OPA-1 (mitochondrial biogenesis) and decreased further in the SHR-O group. Read More

J Food Sci 2019 Apr 18. Epub 2019 Apr 18.

Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), A.C., Unidad de Tecnología Alimentaria, Camino Arenero, 1227, El Bajío, Zapopan, Jalisco, México.

High blood pressure can lead to cardiovascular diseases. The objective of this work was to obtain protein hydrolysates with antihypertensive potential from chia oil industry meal byproduct. Chia seed protein isolates (CPIs) were obtained from chia seed meal byproduct. Read More

J Frailty Aging 2019 ;8(2):88-92

Giovanni Guaraldi, Universita degli Studi di Modena e Reggio Emilia, Italy,

Introduction: Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV.

Objective: The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition.

Methods: In a cross-sectional multicentre retrospective study, we compared three match-control age groups. Read More

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

Pulm Circ 2019 Apr 18:2045894019848649. Epub 2019 Apr 18.

Sheffield Teaching Hospitals NHS Foundation Trust.

Turk J Med Sci 2019 Apr 18;49(2):506-513. Epub 2019 Apr 18.

Background/aim: Intraabdominal hypertension (IAH) occurs frequently in patients with acute pancreatitis and adds to their morbidity and mortality. The main aim of the study was to identify the determination of the predictive factors connected to IAH that influence the evolution of acute pancreatitis.

Materials And Methods: The prospective cohort study was conducted on 100 patients who had acute pancreatitis. Read More

JPEN J Parenter Enteral Nutr 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Pediatric Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

The goal of the 2018 American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally. A growing compendium of research indicates that the incidence and severity of common and costly human diseases may be influenced by dietary exposures and deficiencies that modify the epigenome. The greatest periods of vulnerability to these exposures are the periconception period and early childhood. Read More

Int Arch Occup Environ Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Environmental and Occupational Health, Center for Health, Work, and Environment Colorado School of Public Health, University of Colorado, Anschutz Medical Campus 13001 E. 17th Pl., Ste. W3111, Aurora, CO, 80045, USA.

Objective: Agricultural workers worldwide exposed to heat stress could be at the risk of kidney injury, which could lead to chronic kidney disease of an unknown origin (CKDu). Hydration has been promoted as a key measure to reduce kidney injury. In the presence of a hydration intervention, the incidence of acute kidney injury (AKI) was calculated in a sugarcane worker population in Guatemala and several risk factors were evaluated. Read More

Int J Legal Med 2019 Apr 17. Epub 2019 Apr 17.

INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), University Rennes, 35000, Rennes, France.

Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Read More

BMJ Open Qual 2019 8;8(1):e000373. Epub 2019 Feb 8.

Lynn Community Health Center, Lynn, Massachusetts, USA.

Background: Achieving better care at lower cost in the US healthcare safety net will require federally qualified health centres (FQHC) to implement new models of team-based population healthcare. Lean thinking may offer a way to reduce the financial risk of practice transformation while increasing the likelihood of sustained improvement.

Objective: To demonstrate system-level improvement in hypertension control in a large FQHC through the situational use of lean thinking and statistical process control. Read More

Respir Med Case Rep 2019 1;27:100832. Epub 2019 Apr 1.

Oak Hill Hospital Brooksville, FL, 34613, USA.

Neurofibromatosis Type 1 () is an autosomal dominant genetic disorder with an incidence of approximately 1 in 4,000 live births . Pulmonary arterial hypertension (PAH) is a rare but extremely life-threatening complication associated with . Timely recognition of this unusual and severe association between and PAH is imperative in prolonging the survival in this specific patient population. Read More

Open Heart 2019 25;6(1):e001015. Epub 2019 Mar 25.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.

Methods: Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6. Read More

Open Heart 2019 27;6(1):e000840. Epub 2019 Feb 27.

Department of Cardiology, Herlev and Gentofte University Hospital, Herlev, Denmark.

Aims: To describe the prevalence of heart failure (HF) stages in elderly outpatients with risk factors for HF but without known HF, and characterise the clinical, biochemical and echocardiographic findings in each stage.

Background: Early stages of HF are underdiagnosed; nevertheless, they are associated with an increased risk of hospitalisation and increased mortality. The prevalence of HF stages in elderly high-risk patients is unknown. Read More

Clin Case Rep 2019 Apr 17;7(4):834-835. Epub 2019 Feb 17.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Arteriovenous fistula is a well-known but rarely diagnosed complication of percutaneous renal biopsy. On Doppler sonography, these fistulae are characterized by a region of high velocity shifts and random color assignment due to vibrating interfaces in the perivascular tissue. Most of them resolve spontaneously, while larger symptomatic ones need intervention. Read More

J Cardiol Cases 2019 Apr 29;19(4):125-128. Epub 2018 Dec 29.

Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Intra-cardiac shunt diseases may cause chronic ventricular volume overload, but extra-cardiac fistula could also cause high-output heart failure (HF). A patient presented with high-output HF and significant extra-cardiac shunt flow. Although the size and shape of the patient's left ventricle suggested dilated cardiomyopathy, considerable origins were not identified except for a high-flow fistula between the right subclavian artery and right internal jugular vein. Read More

Eur Heart J Suppl 2019 Apr 10;21(Suppl C):C15-C16. Epub 2019 Apr 10.

Department of Cardiology, 'Asklepeion' General Hospital, Athens, Greece.

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):260-264

Department of Radiology, Peking University Third Hospital, Beijing 100191, China.

Objective: To evaluate cerebral blood flow (CBF) in patients with comorbid hypertension in depression using 3D pseudocontinuous arterial spin labeling (3D pcASL) and to compare the differences of CBF values in depression, hypertension, and comorbid hypertension between depression and healthy control groups. To investigate the correlation between CBF values and degrees of depression.

Methods: Sixteen patients with depression (depression group, 3 males and 13 females, age range of 42-72 years old), sixteen patients with hypertension (hypertension group, 3 males and 13 females, age range of 41-68 years old), sixteen patients with comorbid hypertension in depression (comorbidity group, 3 males and 13 females, age range of 45-74 years old), and sixteen healthy controls (control group, 3 males and 13 females, age range of 43-68 years old) were recruited. Read More

Sci Rep 2019 Apr 17;9(1):6200. Epub 2019 Apr 17.

Division of Cardiovascular Diseases, Mayo Clinic Arizona, Phoenix, Arizona, USA.

Renal denervation (RDN) is a catheter-based ablation procedure designed to treat resistant hypertension (RH). The objective of our study is to determine the effect of RDN on blood pressure and renal function in patients with RH in comparison to medical therapy alone. We performed an extensive literature search for randomized control trials (RCT) reporting office and 24 hr. Read More

Sci Rep 2019 Apr 17;9(1):6232. Epub 2019 Apr 17.

Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

The aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7. Read More

Sci Rep 2019 Apr 17;9(1):6201. Epub 2019 Apr 17.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Japan.

We herein report two cases of patients with thyroid storm with a delayed diagnosis due to psychosis. The patients were a 63-year-old woman with bipolar II disorder and a 37-year-old man with major depressive disorder. The psychoses in both patients were well controlled with medication. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Education and Support for Regional Medicine, Tohoku University Hospital, Japan.

We present a report of a 29-year-old woman with non-dipper type refractory hypertension due to the vascular compression of the medulla oblongata. The patient was diagnosed with hypertension at 17 years of age and underwent emergency Caesarean section at 26 weeks of gestation during 2 pregnancies due to severe high blood pressure. We suspected medullary compression by the curved posterior inferior cerebellar artery as the cause of her intractable hypertension, and she underwent Jannetta's decompression surgery. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.

We herein report a Japanese patient with familial Mediterranean fever (FMF) who developed the clinical manifestations of mixed connective tissue disease (MCTD) and Sjögren's syndrome. The patient was a 36-year-old woman presenting with a periodic short-duration (2-3 days) fever and pleural pain. An MEFV gene analysis detected a complex allele mutation (P369S/R408Q) in exon 3 of the MEFV gene. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiovascular Medicine, Fukushima Medical University, Japan.

Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that leads to right-sided heart failure with electrocardiographic abnormalities. There are only a few reports about the effects of balloon pulmonary angioplasty for CTEPH on the electrocardiographic criteria of right ventricular hypertrophy. Objective To determine the effect of balloon angioplasty on electrocardiography in patients with CTEPH. Read More

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Nerancy Neuro-Intensive Care Unit, University of Virginia, Charlottesville, Virginia, USA.

A young man with severe traumatic brain injury and refractory intracranial hypertension was treated with a barbiturate coma. A rare side effect of barbiturates is dyskalaemia. The dyskalaemia presented with acute hypokalaemia that quickly became hyperkalaemia. Read More

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

DMOP, Basildon University Hospital, Basildon, Essex, UK.

Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiological syndrome characterised by a unique reversible pattern on imaging and total regression of clinical symptoms and signs. We describe an unusual case of PRES with isolated pontine involvement with coincidental acute ischaemic stroke in a 60-year-old man who presented with headache, unsteadiness of gait, blurred vision and elevated blood pressure. MRI scan revealed an expanded pons with diffuse T2 and Fluid attenuated Inversion Recovery (FLAIR) hyperintensities and an acute infarct in the right temporal lobe. Read More

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatorenal syndrome is a severe complication of end-stage cirrhosis characterized by increased splanchnic blood flow, hyperdynamic state, a state of decreased central volume, activation of vasoconstrictor systems, and extreme kidney vasoconstriction leading to decreased GFR. The contribution of systemic inflammation, a key feature of cirrhosis, in the development of hepatorenal syndrome has been highlighted in recent years. The mechanisms by which systemic inflammation precipitates kidney circulatory changes during hepatorenal syndrome need to be clarified. Read More

Heart 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Republic of Korea.

Objective: Left ventricular (LV) geometry change is an independent predictor for cardiovascular disease. However, data are equivocal on the association of echocardiographic parameters of LV geometry with incident hypertension. Thus, we were to investigate the risk of hypertension according to the baseline echocardiographic parameters of LV geometry. Read More

Lancet 2019 Apr 12. Epub 2019 Apr 12.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.

Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. Read More

J Am Heart Assoc 2019 May;8(9):e011856

3 Research Center for Genetic Medicine Children's National Health System Washington DC.

Background The redox-sensitive chaperone DJ -1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal-selective depletion and germline deletion of DJ -1 increases blood pressure in mice. This study aimed to determine the mechanisms involved in the oxidative stress-mediated hypertension in DJ -1 mice. Read More

J Matern Fetal Neonatal Med 2019 Apr 17:1-5. Epub 2019 Apr 17.

a Department of Ultrasonic Diagnosis , Affiliated Hospital of Inner Mongolia Medical University , Hohhot , China.

Objective: To investigate the correlation between changes in brain natriuretic peptide (BNP) and echocardiographic features in persistent pulmonary hypertension of newborn (PPHN).

Patients And Methods: A total of 76 patients with PPHN treated in our hospital from March 2017 to February 2018 were divided into mild group (n = 33), moderate group (n = 22) and severe group (n = 21) according to the pulmonary arterial systolic pressure, and they were compared with 30 normal newborns (control group) during the same period. All newborns underwent echocardiography, the BNP level was detected, and the correlation between echocardiographic features and BNP changes was analyzed. Read More