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J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Department of General Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan.

Inflammatory response in COVID-19 responsible for acute respiratory distress syndrome (ARDS) and multiorgan failure and play a major role in morbidity and mortality of patients. The present study was undertaken to assess serum level of cytokines and its association with other inflammatory markers and disease severity in COVID-19 and hence their prognostic significance.

Methods: This was a retrospective observational study of 175 admitted COVID-19 patients. Read More

J Clin Ultrasound 2022 May 21. Epub 2022 May 21.

Department of Cardiology, Koç University Hospital, Istanbul, Turkey.

Objective: Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. Read More

Isr Med Assoc J 2022 May;24(5):317-319

Infectious Diseases Unit, Samson Assuta Ashdod University Hospital, Ashdod, Israel.

Background: The reduced immune response of maintenance hemodialysis patients to coronavirus disease 2019 (COVID-19) vaccines is a major concern.

Objectives: To analyze the late (6 months after full vaccination) antibody response and compare it to early post-vaccination titer.

Methods: We conducted a multicenter prospective study of 13 hemodialysis units in Israel. Read More

Isr Med Assoc J 2022 May;24(5):310-316

Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Israel.

Background: The association between use of renin-angiotensin-aldosterone (RAAS) inhibitors and both SARS-CoV-2 infection and the development of severe COVID-19 has been presented in the recent medical literature with inconsistent results.

Objectives: To assess the association between RAAS inhibitor use and two outcomes: infection with SARS-CoV-2 (Model 1) and severe COVID-19 among those infected (Model 2).

Methods: We accessed used electronic health records of individuals from Israel who were receiving anti-hypertensive medications for this retrospective study. Read More

BMC Cardiovasc Disord 2022 May 21;22(1):236. Epub 2022 May 21.

Department of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100029, China.

Objective: We aimed to investigate the effect of the triglyceride glucose (TyG) index on the association between diabetes and cardiovascular disease (CVD).

Methods: Data from 6,114 individuals were extracted and analyzed from the China Health and Retirement Longitudinal Survey (CHARLS) from 2011 to 2018. Logistic regression analyses were conducted to assess the relationship between diabetes and CVD across the various TyG index groups. Read More

BMC Med Res Methodol 2022 May 21;22(1):148. Epub 2022 May 21.

Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, 13001 E. 17th Pl, Aurora, CO, USA.

Background: Missing data prove troublesome in data analysis; at best they reduce a study's statistical power and at worst they induce bias in parameter estimates. Multiple imputation via chained equations is a popular technique for dealing with missing data. However, techniques for combining and pooling results from fitted generalized additive models (GAMs) after multiple imputation have not been well explored. Read More

BMC Cardiovasc Disord 2022 May 21;22(1):237. Epub 2022 May 21.

Heart Institute (InCor) University of Sao Paulo Medical School Hospital, São Paulo, Brazil.

Background And Objective: Non-communicable diseases like systemic arterial hypertension (SAH) and dyslipidemia are poorly studied in terms of patient journey aspects. This semi-systematic review provides evidence synthesis for the management of SAH and dyslipidemia in Brazil and also discusses challenges faced by patients at the local level along with a suggested care approach by local experts.

Methods: A semi-systematic review using both structured literature databases (Embase and Medline) and unstructured scientific records (WHO, IPD, MOH and Google) on hypertension and dyslipidemia in the English language from 2010 to 2019 was performed by reviewers. Read More

BMC Neurol 2022 May 21;22(1):187. Epub 2022 May 21.

Department of Gastroenterology, Faculty of Medicine, Başkent University, Ankara, Turkey.

Background/aim: White matter lesions (WML) are more frequently observed in migraine patients than in the average population. Associations between Helicobacter pylori (H. pylori) infection and different extraintestinal pathologies have been identified. Read More

Acta Neurochir (Wien) 2022 May 21. Epub 2022 May 21.

Department of Neurosurgery, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074, Aachen, Germany.

Purpose: Decompressive hemicraniectomy (DHC) is a potentially lifesaving procedure in refractory intracranial hypertension, which can prevent death from brainstem herniation but may cause survival in a disabled state. The spectrum of indications is expanding, and we present long-term results in a series of patients suffering from aneurysmal subarachnoid hemorrhage (SAH).

Methods: We performed a retrospective analysis of previously registered data including all patients treated for SAH between 2010 and 2018 in a single institution. Read More

Hormones (Athens) 2022 May 21. Epub 2022 May 21.

Institute and Department of Endocrinology, Shanghai Ruijin Hospital, Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The aim of this study was to determine the association between hypertriglyceridemic waist (HTGW) phenotype and non-alcoholic fatty liver disease (NAFLD) in a middle- to older-aged Chinese population.

Methods: In this cross-sectional study, a total of 9015 participants (age 40-79 years) were recruited and grouped into four phenotypes, as follows: NWNT: normal waist-normal triglyceride; NWET: normal waist-elevated triglycerides; EWNT: elevated waist-normal triglycerides; and hypertriglyceridemic waist (HTGW). Logistic regression analysis was carried out to assess the associations between HTGW phenotype and NAFLD. Read More

J Diabetes Complications 2022 May 9:108208. Epub 2022 May 9.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Given that the prevalence of hypertension increases with age and is more common among adults with diabetes than those without diabetes, the objective of this study was to examine trends in hypertension prevalence by geographic region among older adults with and without diabetes. Among older adults with diabetes, hypertension prevalence generally increased from 2005 to 2017 across all regions, although the annual percent change was lower from 2011 to 2017 than 2005-2011 for all regions. Read More

Transplant Proc 2022 May 18. Epub 2022 May 18.

Institute of Cardiology and Transplantation of the Federal District (ICTDF), Brasilia, Brazil.

Background: Portal vein thrombosis is a relatively frequent complication in patients with liver cirrhosis. Its detection and management are essential to avoid worsening portal hypertension or liver function complications. This complication can also negatively impact or even preclude liver transplant. Read More

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

The simultaneous presence of pulmonary arterial hypertension (PAH) and secondary tricuspid regurgitation (STR) portends particularly poor outcomes. However, not all patients with PAH develop significant STR, and the mechanisms and clinical implications underlying this phenomenon remain unclear. We sought to describe the functional, anatomic, hemodynamic, and clinical characteristics of patients with PAH with and without STR. Read More

Kidney Int 2022 Jun;101(6):1304

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Kidney Int 2022 Jun;101(6):1298-1299

International Federation of Kidney Foundations-World Kidney Alliance, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Int J Infect Dis 2022 May 18. Epub 2022 May 18.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 67 Huntingdon St, Boston, USA.

Objectives Cardiovascular diseases (CVD) burden is rising among persons living with HIV (PLWH) in sub-Saharan Africa. It is unclear whether this reflects absolute increase in HIV-related CVD risk or unmasking by improved survival. We, therefore, examined whether HIV is associated with adverse cardiometabolic profiles among South African adults. Read More

World Neurosurg 2022 May 18. Epub 2022 May 18.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Vascular malformations in the dura of the spinal root sleeve in the thoracic or lumbar region can cause venous hypertension with resultant spinal cord edema and neurologic deterioration. However, occasionally an intracranial vascular malformation can have venous drainage into the spinal canal causing symptoms, signs and radiographic appearance that can mimic spinal lesions. Herein, we present the case of a 73 year-old man who developed lower extremity weakness and loss of sensation. Read More

Can J Cardiol 2022 May 18. Epub 2022 May 18.

Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research; Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Hypertension is the leading risk factor for cardiovascular disease and mortality worldwide. Despite intensive research into the mechanisms underlying the development of hypertension, it remains difficult to control blood pressure in a large proportion of patients. Young men have a higher prevalence of hypertension compared to age-matched women, and this holds true until approximately the fifth decade of life. Read More

Vascul Pharmacol 2022 May 18:106999. Epub 2022 May 18.

Laboratory for Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland; Institute of Life Science, Scuola Superiore Sant'Anna, Pisa, Italy.. Electronic address:

Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their surface. CD142-EV turned out to be useful as diagnostic biomarker in COVID-19 patients. Here we aimed at studying the prognostic capacity of CD142-EV in SARS-CoV-2 infection. Read More

Trends Cardiovasc Med 2022 May 18. Epub 2022 May 18.

Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA.

Type 2 Diabetes Mellitus (T2DM) is a pandemic that affects millions of patients worldwide. Diabetes affects multiple organ systems leading to comorbidities including hypertension. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) recently have been approved for the treatment of T2DM and heart failure with reduced and preserved ejection fraction. Read More

Pharmacol Ther 2022 May 18:108213. Epub 2022 May 18.

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA.

Adenosine is a ubiquitous endogenous nucleoside or autacoid that affects the cardiovascular system through the activation of four G-protein coupled receptors: adenosine A receptor (AAR), adenosine A receptor (AAR), adenosine A receptor (AAR), and adenosine A receptor (AAR). With the rapid generation of this nucleoside from cellular metabolism and the widespread distribution of its four G-protein coupled receptors in almost all organs and tissues of the body, this autacoid induces multiple physiological as well as pathological effects, not only regulating the cardiovascular system but also the central nervous system, peripheral vascular system, and immune system. Mounting evidence shows the role of CYP450-enzymes in cardiovascular physiology and pathology, and the genetic polymorphisms in CYP450s can increase susceptibility to cardiovascular diseases (CVDs). Read More

J Ren Nutr 2022 May 18. Epub 2022 May 18.

Professor of Clinical Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA.

Current phosphate management strategies in end-stage renal disease (dietary phosphate restriction, dialysis, and phosphate binders) are inadequate to maintain target phosphate levels in most patients. Dietary phosphate restriction is challenging due to "hidden phosphates" in processed foods, and dialysis and phosphate binders are insufficient to match average dietary phosphate intake. As phosphate binders must be taken with each meal, patients need to ingest many, large pills several times a day, negatively impacting quality of life. Read More

J Ren Nutr 2022 May 18. Epub 2022 May 18.

Duke Cancer Institute, Duke University, Durham, NC; Department of Family Medicine and Community Health, Duke University School of Medicine, Durham, NC.

Objective: The Dietary Approaches to Stop Hypertension eating plan (DASH) improves hypertension in Black individuals and is associated with favorable chronic kidney disease (CKD) outcomes. Yet, adherence to DASH is low among US adults in general, particularly among Black Americans. We assessed perceptions about DASH, its cultural compatibility, and barriers and facilitators to DASH adherence in Black adults with CKD. Read More

Lancet Haematol 2022 May 18. Epub 2022 May 18.

University Clinic for Haematology, Oncology, Haemostaseology and Palliative Care, Johannes Wesling Medical Centre Minden, University of Bochum, Minden, Germany.

Background: The phase 3b, randomised, open-label RESPONSE-2 study in patients with inadequately controlled polycythaemia vera without splenomegaly showed superiority of the Janus kinase (JAK) 1 and JAK2 inhibitor ruxolitinib versus best available therapy for the primary endpoint of haematocrit control at week 28. Here, we present secondary endpoints of the RESPONSE-2 study after 5 years of follow-up.

Methods: RESPONSE-2 was an open-label, randomised, phase 3b study done at 48 hospitals or clinics across 12 countries in Asia, Australia, Europe, and Canada. Read More

Heart Lung 2022 May 18;55:146-147. Epub 2022 May 18.

Institution: Andhra Medical College, Visakhapatnam, Andhra Pradesh, India; Institute: Dow University of Health Sciences, Karachi. Electronic address:

J Trace Elem Med Biol 2022 May 6;72:126991. Epub 2022 May 6.

Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address:

Background And Aim: Evidence suggests an association between essential and toxic elements and the worsening of cardiometabolic risk factors. This study aimed to investigate the concentrations of zinc, copper, selenium, arsenic, cadmium, and mercury and their relationship with cardiometabolic risk factors in adults and older people.

Methods: This cross-sectional study was carried out with 112 adults with a mean age of 59 (sd 14) years old and a BMI of 29. Read More

J Clin Neurosci 2022 May 18;101:168-174. Epub 2022 May 18.

Ege University, Department of Administration and Statistics, İzmir, Turkey. Electronic address:

Post-stroke depression is one of the main causes of cerebrovascular and cardiovascular diseases. The aim of the present study was to investigate the efficacy of citalopram on stroke recurrence. A 52-week, randomized, double-blind, studyinvolved 440 ischemic stroke patients with depression. Read More

J Clin Neurosci 2022 May 18;101:144-149. Epub 2022 May 18.

Department of Neurosurgery, Monash Health, Level 5, Block D, 246 Clayton Road, Clayton, Victoria 3168, Australia; Department of Surgery, Monash Medical Centre, Level 5, Block E, 246 Clayton Road, Clayton, Victoria 3168, Australia.

Introduction: Smoking and hypertension are prevalent among Indigenous Australians (Aboriginal and Torres Strait Islanders). We investigated if these risk factors suggest a greater rate of aneurysmal subarachnoid haemorrhage in Indigenous Australians (IA) compared to non-IA.

Materials And Methods: A retrospective cross-sectional study was performed on data retrieved from the Nationwide Hospital Morbidity Database for all aSAH cases in Australia between 2012 and 2018. Read More

J Surg Res 2022 May 18;278:100-110. Epub 2022 May 18.

Department of Surgery, MedStar Washington Hospital Center, Washington, District of Columbia; Department of Surgery, Georgetown University School of Medicine, Washington, District of Columbia.

Introduction: Negative pressure wound therapy (NPWT) is commonly used in open abdomen management, where there may be a simultaneous need for prevention of abdominal hypertension, tamponade of hemorrhage, and continuous fascial tension. The regional pressure dynamics of vacuum dressings are poorly understood.

Methods: Three duroc swine underwent mid-line laparotomy and application of vacuum open abdomen dressing, with and without sponge packing. Read More

Eur J Heart Fail 2022 May 21. Epub 2022 May 21.

University of Bergen, Stavanger University Hospital, Stavanger, Norway.

Background: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, might have beneficial effects on pulmonary haemodynamics, cardiac function and exercise capacity in HFrEF and PHT.

Aims: To determine the safety, tolerability, and efficacy of sildenafil in patients with HFrEF and indirect evidence of PHT. Read More